TOX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)9.61459135
2regulation of retinoic acid receptor signaling pathway (GO:0048385)8.16446398
3sleep (GO:0030431)6.10270319
4response to pheromone (GO:0019236)5.18323006
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13662102
6lung epithelium development (GO:0060428)4.84110839
7synaptic vesicle exocytosis (GO:0016079)4.75724298
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.68174109
9regulation of cell maturation (GO:1903429)4.61343914
10negative regulation of synaptic transmission, GABAergic (GO:0032229)4.48859127
11neuron cell-cell adhesion (GO:0007158)4.48357069
12layer formation in cerebral cortex (GO:0021819)4.44316093
13synaptic vesicle maturation (GO:0016188)4.37706168
14vocalization behavior (GO:0071625)4.30285139
15dendritic spine morphogenesis (GO:0060997)4.27815410
16regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.14669473
17glutamate secretion (GO:0014047)4.13364704
18regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.12338698
19protein localization to synapse (GO:0035418)4.11477349
20neuron projection extension (GO:1990138)4.04734433
21regulation of synaptic vesicle exocytosis (GO:2000300)4.01955285
22righting reflex (GO:0060013)3.95780005
23regulation of acrosome reaction (GO:0060046)3.81174571
24regulation of glutamate receptor signaling pathway (GO:1900449)3.75329708
25neuronal action potential propagation (GO:0019227)3.75164425
26innervation (GO:0060384)3.73716845
27neuron recognition (GO:0008038)3.72568917
28axonal fasciculation (GO:0007413)3.70519954
29cell migration in hindbrain (GO:0021535)3.70184208
30retinal ganglion cell axon guidance (GO:0031290)3.69974888
31regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.68745406
32response to gravity (GO:0009629)3.68221600
33negative regulation of glycogen biosynthetic process (GO:0045719)3.67532169
34positive regulation of synapse maturation (GO:0090129)3.67413852
35positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.65622311
36mammary gland epithelial cell proliferation (GO:0033598)3.64146106
37cellular response to interleukin-15 (GO:0071350)3.62469313
38neurotransmitter secretion (GO:0007269)3.61986265
39male sex determination (GO:0030238)3.59640522
40peptidyl-threonine dephosphorylation (GO:0035970)3.59605303
41cellular response to prostaglandin stimulus (GO:0071379)3.56954365
42response to auditory stimulus (GO:0010996)3.55744117
43cellular potassium ion homeostasis (GO:0030007)3.54173785
44sodium ion export (GO:0071436)3.51159517
45axon extension (GO:0048675)3.51056697
46locomotory exploration behavior (GO:0035641)3.50693399
47activation of MAPKKK activity (GO:0000185)3.47560885
48positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.46944042
49developmental cell growth (GO:0048588)3.45271492
50N-glycan processing (GO:0006491)3.45244072
51auditory behavior (GO:0031223)3.44739695
52regulation of prostaglandin secretion (GO:0032306)3.44531416
53regulation of synaptic vesicle transport (GO:1902803)3.43534762
54cerebellar Purkinje cell differentiation (GO:0021702)3.42984493
55multicellular organism reproduction (GO:0032504)3.42268994
56inactivation of MAPK activity (GO:0000188)3.42265290
57positive regulation of synaptic transmission, GABAergic (GO:0032230)3.41039731
58positive regulation of prostaglandin secretion (GO:0032308)3.40802224
59glandular epithelial cell development (GO:0002068)3.38854345
60regulation of respiratory system process (GO:0044065)3.38333828
61neuron projection extension involved in neuron projection guidance (GO:1902284)3.36553509
62axon extension involved in axon guidance (GO:0048846)3.36553509
63negative regulation of cytosolic calcium ion concentration (GO:0051481)3.36510029
64type B pancreatic cell development (GO:0003323)3.35254882
65neuromuscular process controlling posture (GO:0050884)3.30126379
66positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29308339
67ionotropic glutamate receptor signaling pathway (GO:0035235)3.28434586
68gamma-aminobutyric acid transport (GO:0015812)3.25220966
69somite development (GO:0061053)3.24921583
70synaptic vesicle endocytosis (GO:0048488)3.23535511
71positive regulation of osteoclast differentiation (GO:0045672)3.22204732
72regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21693060
73endoderm formation (GO:0001706)3.20351953
74membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.18848665
75negative regulation of microtubule polymerization (GO:0031115)3.18534788
76negative regulation of axon guidance (GO:1902668)3.17311416
77glutamate receptor signaling pathway (GO:0007215)3.16499813
78response to muramyl dipeptide (GO:0032495)3.14947796
79neurotransmitter transport (GO:0006836)3.14458114
80thalamus development (GO:0021794)3.14138098
81positive regulation of oligodendrocyte differentiation (GO:0048714)3.14054836
82regulation of fever generation (GO:0031620)3.13061336
83behavioral response to nicotine (GO:0035095)3.12875462
84negative regulation of glycogen metabolic process (GO:0070874)3.12754160
85ganglion development (GO:0061548)3.11734337
86regulation of neuronal synaptic plasticity (GO:0048168)3.11539735
87regulation of synapse structural plasticity (GO:0051823)3.09388121
88cellular response to pH (GO:0071467)3.08997888
89limb bud formation (GO:0060174)3.07004722
90interleukin-6-mediated signaling pathway (GO:0070102)3.06857878
91regulation of respiratory gaseous exchange (GO:0043576)3.05520695
92exploration behavior (GO:0035640)3.04997900
93positive regulation of heat generation (GO:0031652)3.04884673
94membrane hyperpolarization (GO:0060081)3.04268982
95mating behavior (GO:0007617)3.03471027
96regulation of long-term neuronal synaptic plasticity (GO:0048169)3.03261398
97substrate-dependent cell migration (GO:0006929)3.03111835
98positive regulation of synapse assembly (GO:0051965)3.01623725
99glycine transport (GO:0015816)3.01598125
100regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.00944446
101mammary gland alveolus development (GO:0060749)2.98963354
102dendrite morphogenesis (GO:0048813)2.98727650
103dopaminergic neuron differentiation (GO:0071542)2.98137372
104regulation of synapse maturation (GO:0090128)2.97935786
105neurotransmitter-gated ion channel clustering (GO:0072578)2.97103445
106gamma-aminobutyric acid signaling pathway (GO:0007214)2.95907606
107neuron-neuron synaptic transmission (GO:0007270)2.93966155
108adhesion of symbiont to host (GO:0044406)2.93021456
109neuronal ion channel clustering (GO:0045161)2.92562352
110negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92530968
111negative regulation of cell killing (GO:0031342)2.92530968
112germ cell migration (GO:0008354)2.91694730
113establishment of synaptic vesicle localization (GO:0097480)2.90762899
114synaptic vesicle transport (GO:0048489)2.90762899
115establishment of nucleus localization (GO:0040023)2.90660675
116pyrimidine nucleobase catabolic process (GO:0006208)2.90634055
117regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.89438981
118synaptic vesicle docking involved in exocytosis (GO:0016081)2.88837093
119G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.88207391
120synapse assembly (GO:0007416)2.88168286
121regulation of neurotransmitter levels (GO:0001505)2.87738558
122transmission of nerve impulse (GO:0019226)2.87558812
123cell communication by electrical coupling (GO:0010644)2.86957179
124synaptic transmission, glutamatergic (GO:0035249)2.86080547
125lens fiber cell development (GO:0070307)2.84257437
126membrane depolarization during action potential (GO:0086010)2.82428051
127response to interleukin-15 (GO:0070672)2.79872619
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.79664086
129proline transport (GO:0015824)2.78614535
130startle response (GO:0001964)2.78515385
131regulation of axon guidance (GO:1902667)2.77875683
132positive regulation of axon extension (GO:0045773)2.77220737
133negative regulation of DNA-templated transcription, elongation (GO:0032785)2.77121829
134regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.76345053
135vesicle transport along microtubule (GO:0047496)2.76133883
136neuroblast proliferation (GO:0007405)2.75947025
137negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.75488218
138negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.74554182
139RNA destabilization (GO:0050779)2.73713125
140positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.73679616
141regulation of vesicle fusion (GO:0031338)2.73419123
142central nervous system projection neuron axonogenesis (GO:0021952)2.73091767
143negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71641449
144negative regulation of axon extension (GO:0030517)2.71196873
145regulation of female gonad development (GO:2000194)2.69797350
146regulation of synaptic transmission, glutamatergic (GO:0051966)2.69506903
147regulation of postsynaptic membrane potential (GO:0060078)2.69205804
148astrocyte differentiation (GO:0048708)2.68575218
149axon cargo transport (GO:0008088)2.68194623
150negative regulation of dendrite development (GO:2000171)2.68171981
151histone H3-K4 trimethylation (GO:0080182)2.66776399
152histone H2A monoubiquitination (GO:0035518)2.61456135
153positive regulation of action potential (GO:0045760)2.60306774
154positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.60284725
155positive regulation of uterine smooth muscle contraction (GO:0070474)2.58667813
156positive regulation of humoral immune response (GO:0002922)2.58428760
157maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.57894545
158cytoplasmic sequestering of transcription factor (GO:0042994)2.57884094
159regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.57766564
160regulation of alkaline phosphatase activity (GO:0010692)2.57508768
161piRNA metabolic process (GO:0034587)2.57226025
162negative regulation of meiotic cell cycle (GO:0051447)2.55406765
163response to corticosterone (GO:0051412)2.54724772
164positive regulation of G2/M transition of mitotic cell cycle (GO:0010971)2.53117978
165positive regulation of cell cycle G2/M phase transition (GO:1902751)2.53117978
166histone H2B ubiquitination (GO:0033523)2.51794049
167positive regulation of T cell cytokine production (GO:0002726)2.49266075
168histone monoubiquitination (GO:0010390)2.48231221
169postsynaptic membrane organization (GO:0001941)2.47835165
170positive regulation of glial cell differentiation (GO:0045687)2.46934008
171dopamine biosynthetic process (GO:0042416)2.45833479
172gonadal mesoderm development (GO:0007506)2.45482048
173bone resorption (GO:0045453)2.45457048
174sex determination (GO:0007530)2.44806423
175negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.43942474
176response to mineralocorticoid (GO:0051385)2.42289967
177protein localization to microtubule cytoskeleton (GO:0072698)2.40381344
178protein heterotrimerization (GO:0070208)2.39136487
179protein localization to endosome (GO:0036010)2.37604678
180negative regulation of glucose import (GO:0046325)2.37023837
181facial nerve structural organization (GO:0021612)2.34405412
182regulation of homotypic cell-cell adhesion (GO:0034110)2.33872128
183adaptation of signaling pathway (GO:0023058)2.33199316
184ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.30942289
185adenosine metabolic process (GO:0046085)2.30860099
186regulation of transcription elongation from RNA polymerase II promoter (GO:0034243)2.30017053
187face development (GO:0060324)2.27760275
188regulation of heat generation (GO:0031650)2.27758905
189protein localization to cytoskeleton (GO:0044380)2.27542380
190CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.24409507

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.95947959
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.07557388
3GBX2_23144817_ChIP-Seq_PC3_Human3.51853232
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.25880309
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.18890198
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15257821
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.95888546
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.92409818
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.92409818
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.91643668
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.82756757
12TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.78482748
13EED_16625203_ChIP-ChIP_MESCs_Mouse2.74289629
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.61905284
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.60354311
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.58075749
17REST_21632747_ChIP-Seq_MESCs_Mouse2.53189200
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.51584863
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.51375060
20* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.49264115
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.47750842
22SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.42695383
23MTF2_20144788_ChIP-Seq_MESCs_Mouse2.41917784
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.36207769
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.35911524
26DROSHA_22980978_ChIP-Seq_HELA_Human2.35341514
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.12341557
28PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.06859771
29BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.06085253
30* CBX2_27304074_Chip-Seq_ESCs_Mouse2.03031468
31TAF15_26573619_Chip-Seq_HEK293_Human2.02471529
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.01715936
33IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01124280
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97435323
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91471542
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91015629
37AR_21572438_ChIP-Seq_LNCaP_Human1.87469665
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.82775306
39RARB_27405468_Chip-Seq_BRAIN_Mouse1.82632385
40ELK3_25401928_ChIP-Seq_HUVEC_Human1.82345888
41ZNF274_21170338_ChIP-Seq_K562_Hela1.81161601
42RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.77073421
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.74043180
44* LXR_22292898_ChIP-Seq_THP-1_Human1.70349395
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.68333222
46IGF1R_20145208_ChIP-Seq_DFB_Human1.68313593
47RNF2_27304074_Chip-Seq_NSC_Mouse1.68140894
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67215930
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.65904747
50* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61088624
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55980853
52* KDM2B_26808549_Chip-Seq_JURKAT_Human1.54856376
53RING1B_27294783_Chip-Seq_ESCs_Mouse1.54244306
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52342323
55ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49976742
56P300_19829295_ChIP-Seq_ESCs_Human1.49762033
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.49009585
58KDM2B_26808549_Chip-Seq_DND41_Human1.48057672
59SMAD4_21799915_ChIP-Seq_A2780_Human1.47494787
60ZFP281_27345836_Chip-Seq_ESCs_Mouse1.44561848
61* ERG_21242973_ChIP-ChIP_JURKAT_Human1.39309689
62NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38615036
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.38279392
64CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.37707070
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.37296441
66TP53_22127205_ChIP-Seq_IMR90_Human1.37171134
67ELK4_26923725_Chip-Seq_MESODERM_Mouse1.35772942
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35475274
69TET1_21451524_ChIP-Seq_MESCs_Mouse1.32775823
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31909566
71TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30495603
72PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29159163
73* P68_20966046_ChIP-Seq_HELA_Human1.27379685
74PIAS1_25552417_ChIP-Seq_VCAP_Human1.26924021
75DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.26679186
76MYC_22102868_ChIP-Seq_BL_Human1.26658031
77AR_25329375_ChIP-Seq_VCAP_Human1.26653516
78AR_19668381_ChIP-Seq_PC3_Human1.24428340
79TP53_20018659_ChIP-ChIP_R1E_Mouse1.23319723
80* RING1B_27294783_Chip-Seq_NPCs_Mouse1.23053106
81* BCL6_27268052_Chip-Seq_Bcells_Human1.21907683
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19775045
83SOX2_21211035_ChIP-Seq_LN229_Gbm1.18607151
84STAT6_21828071_ChIP-Seq_BEAS2B_Human1.17975309
85P53_22127205_ChIP-Seq_FIBROBLAST_Human1.17791245
86OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.17748398
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17169395
88UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16828396
89* SMAD3_21741376_ChIP-Seq_EPCs_Human1.16408841
90* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15957847
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.15853131
92TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15242594
93CTCF_27219007_Chip-Seq_Bcells_Human1.13189913
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.11684734
95FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.11299158
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10283540
97* RUNX_20019798_ChIP-Seq_JUKART_Human1.10255748
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.09354127
99DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08726775
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08340143
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06541888
102* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06482511
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06481058
104ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06010245
105CTCF_20526341_ChIP-Seq_ESCs_Human1.05633312
106TET1_21490601_ChIP-Seq_MESCs_Mouse1.04528425
107AHR_22903824_ChIP-Seq_MCF-7_Human1.03342198
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.03323459
109RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03149479
110PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01687804
111CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00638089
112ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.99794838
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99718607
114TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99498832
115OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99487602
116* STAT3_23295773_ChIP-Seq_U87_Human0.99301485
117STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98519355
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97354150
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97354150
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96787056
121FOXM1_23109430_ChIP-Seq_U2OS_Human0.96472892
122UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96284333
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.95882517
124CREB1_26743006_Chip-Seq_LNCaP_Human0.95275700
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.95211639
126* TCF7_22412390_ChIP-Seq_EML_Mouse0.94141908
127ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92660948
128ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92650076
129* SMAD4_21741376_ChIP-Seq_HESCs_Human0.92201578
130VDR_22108803_ChIP-Seq_LS180_Human0.91806090
131* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91626700
132SMAD3_21741376_ChIP-Seq_ESCs_Human0.91503846
133EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91362574
134CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90804968
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90603178
136STAT4_19710469_ChIP-ChIP_TH1__Mouse0.90234585
137ELF1_20517297_ChIP-Seq_JURKAT_Human0.90148224
138* RUNX2_22187159_ChIP-Seq_PCA_Human0.89811719
139EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89363891
140CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89147577
141POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88859265
142CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.88828300
143TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88753975
144GATA1_26923725_Chip-Seq_HPCs_Mouse0.87624711
145KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.87492835
146JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87076429
147MAF_26560356_Chip-Seq_TH2_Human0.86884967
148KDM2B_26808549_Chip-Seq_K562_Human0.86769002
149ZNF217_24962896_ChIP-Seq_MCF-7_Human0.86536491
150SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.86213209
151SMC3_22415368_ChIP-Seq_MEFs_Mouse0.86187155
152NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85911547
153JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85850887
154JUN_21703547_ChIP-Seq_K562_Human0.84512853
155* PRDM14_20953172_ChIP-Seq_ESCs_Human0.83904686
156CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83497503
157BCAT_22108803_ChIP-Seq_LS180_Human0.83261390
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82873447

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.06545902
2MP0004859_abnormal_synaptic_plasticity4.09639086
3MP0005423_abnormal_somatic_nervous3.90396323
4MP0002102_abnormal_ear_morphology3.34645385
5MP0003283_abnormal_digestive_organ3.24925593
6MP0003122_maternal_imprinting3.19267844
7MP0006276_abnormal_autonomic_nervous3.11540274
8MP0003635_abnormal_synaptic_transmissio3.09322679
9MP0001968_abnormal_touch/_nociception2.88911486
10MP0001529_abnormal_vocalization2.75642597
11MP0010368_abnormal_lymphatic_system2.55021172
12MP0002063_abnormal_learning/memory/cond2.43552823
13MP0002064_seizures2.42507674
14MP0000778_abnormal_nervous_system2.42058886
15MP0008877_abnormal_DNA_methylation2.41891612
16MP0004270_analgesia2.37801404
17MP0009745_abnormal_behavioral_response2.28374151
18MP0005623_abnormal_meninges_morphology2.19158947
19MP0000566_synostosis2.17152993
20MP0009780_abnormal_chondrocyte_physiolo2.16891710
21MP0009046_muscle_twitch2.15077063
22MP0002572_abnormal_emotion/affect_behav2.13276156
23MP0002877_abnormal_melanocyte_morpholog2.12802832
24MP0002736_abnormal_nociception_after2.05088418
25MP0002184_abnormal_innervation2.04429179
26MP0001486_abnormal_startle_reflex2.03076066
27MP0002734_abnormal_mechanical_nocicepti2.01806368
28MP0002272_abnormal_nervous_system2.00801002
29MP0002933_joint_inflammation1.98083636
30MP0002234_abnormal_pharynx_morphology1.96305760
31MP0002733_abnormal_thermal_nociception1.96267645
32MP0002735_abnormal_chemical_nociception1.88145596
33MP0005646_abnormal_pituitary_gland1.80944089
34MP0000685_abnormal_immune_system1.78200012
35MP0001501_abnormal_sleep_pattern1.77223642
36MP0002638_abnormal_pupillary_reflex1.77144930
37MP0002067_abnormal_sensory_capabilities1.76944127
38MP0005645_abnormal_hypothalamus_physiol1.76045417
39MP0000569_abnormal_digit_pigmentation1.69336236
40MP0002751_abnormal_autonomic_nervous1.69323064
41MP0001970_abnormal_pain_threshold1.66053188
42MP0001879_abnormal_lymphatic_vessel1.65105162
43MP0004924_abnormal_behavior1.63293807
44MP0005386_behavior/neurological_phenoty1.63293807
45MP0001440_abnormal_grooming_behavior1.61636150
46MP0002557_abnormal_social/conspecific_i1.60325048
47MP0005076_abnormal_cell_differentiation1.53957733
48MP0000955_abnormal_spinal_cord1.53048739
49MP0002932_abnormal_joint_morphology1.51458906
50MP0003436_decreased_susceptibility_to1.49230514
51MP0002882_abnormal_neuron_morphology1.46738470
52MP0001984_abnormal_olfaction1.46160083
53MP0005551_abnormal_eye_electrophysiolog1.46123366
54MP0001348_abnormal_lacrimal_gland1.45647727
55MP0004811_abnormal_neuron_physiology1.43638137
56MP0001502_abnormal_circadian_rhythm1.40453035
57MP0002909_abnormal_adrenal_gland1.38128235
58MP0001905_abnormal_dopamine_level1.37708794
59MP0008961_abnormal_basal_metabolism1.35392622
60MP0003763_abnormal_thymus_physiology1.35304911
61MP0003121_genomic_imprinting1.35014119
62MP0009250_abnormal_appendicular_skeleto1.33952342
63MP0008569_lethality_at_weaning1.33010139
64MP0005390_skeleton_phenotype1.29571555
65MP0005508_abnormal_skeleton_morphology1.29060031
66MP0000750_abnormal_muscle_regeneration1.27513433
67MP0002876_abnormal_thyroid_physiology1.27192422
68MP0004142_abnormal_muscle_tone1.27099195
69MP0004742_abnormal_vestibular_system1.26401020
70MP0001188_hyperpigmentation1.24279340
71MP0003938_abnormal_ear_development1.22944855
72MP0005257_abnormal_intraocular_pressure1.21279557
73MP0006072_abnormal_retinal_apoptosis1.19478678
74MP0003787_abnormal_imprinting1.19086776
75MP0003091_abnormal_cell_migration1.19022555
76MP0001986_abnormal_taste_sensitivity1.18261666
77MP0002998_abnormal_bone_remodeling1.17806829
78MP0004858_abnormal_nervous_system1.15794343
79MP0009053_abnormal_anal_canal1.15376193
80MP0002152_abnormal_brain_morphology1.14347701
81MP0005671_abnormal_response_to1.13648197
82MP0002066_abnormal_motor_capabilities/c1.12904483
83MP0000631_abnormal_neuroendocrine_gland1.12054949
84MP0002752_abnormal_somatic_nervous1.10672866
85MP0009840_abnormal_foam_cell1.07160012
86MP0005394_taste/olfaction_phenotype1.06949920
87MP0005499_abnormal_olfactory_system1.06949920
88MP0008438_abnormal_cutaneous_collagen1.06203328
89MP0000026_abnormal_inner_ear1.06202969
90MP0008874_decreased_physiological_sensi1.05509272
91MP0003329_amyloid_beta_deposits1.04999950
92MP0001533_abnormal_skeleton_physiology1.04093438
93MP0001542_abnormal_bone_strength1.03527868
94MP0002282_abnormal_trachea_morphology1.02639789
95MP0000733_abnormal_muscle_development1.01291795
96MP0000537_abnormal_urethra_morphology0.98928979
97MP0002653_abnormal_ependyma_morphology0.97140429
98MP0000767_abnormal_smooth_muscle0.95338344
99MP0005377_hearing/vestibular/ear_phenot0.94060371
100MP0003878_abnormal_ear_physiology0.94060371
101MP0010030_abnormal_orbit_morphology0.93860220
102MP0006292_abnormal_olfactory_placode0.91550899
103MP0003861_abnormal_nervous_system0.91114182
104MP0000751_myopathy0.89431818
105MP0003279_aneurysm0.89127460
106MP0000003_abnormal_adipose_tissue0.88793100
107MP0002177_abnormal_outer_ear0.88590698
108MP0002822_catalepsy0.87431829
109MP0003183_abnormal_peptide_metabolism0.87388266
110MP0003699_abnormal_female_reproductive0.86806898
111MP0010386_abnormal_urinary_bladder0.86434204
112MP0002163_abnormal_gland_morphology0.85789228
113MP0005253_abnormal_eye_physiology0.85761686
114MP0003634_abnormal_glial_cell0.85148849
115MP0001299_abnormal_eye_distance/0.84514734
116MP0002210_abnormal_sex_determination0.83455856
117MP0004947_skin_inflammation0.82915202
118MP0005000_abnormal_immune_tolerance0.81771021
119MP0004233_abnormal_muscle_weight0.81576340
120MP0001919_abnormal_reproductive_system0.79614326
121MP0001943_abnormal_respiration0.78436315
122MP0002928_abnormal_bile_duct0.77497578
123MP0002090_abnormal_vision0.76635498
124MP0002332_abnormal_exercise_endurance0.76337228
125MP0003959_abnormal_lean_body0.76303604
126MP0003950_abnormal_plasma_membrane0.75904073
127MP0002069_abnormal_eating/drinking_beha0.75714549
128MP0008789_abnormal_olfactory_epithelium0.75056356
129MP0001963_abnormal_hearing_physiology0.74841027
130MP0000049_abnormal_middle_ear0.72148165
131MP0004133_heterotaxia0.71881865
132MP0002229_neurodegeneration0.71604425
133MP0000639_abnormal_adrenal_gland0.71032952
134MP0001881_abnormal_mammary_gland0.70983411
135MP0001340_abnormal_eyelid_morphology0.70785201
136MP0008872_abnormal_physiological_respon0.68767707
137MP0002249_abnormal_larynx_morphology0.67576253
138MP0003137_abnormal_impulse_conducting0.66814076
139MP0004885_abnormal_endolymph0.66414361
140MP0005195_abnormal_posterior_eye0.65200741
141MP0000462_abnormal_digestive_system0.64766461
142MP0003879_abnormal_hair_cell0.64035094
143MP0000534_abnormal_ureter_morphology0.60578548
144MP0003942_abnormal_urinary_system0.60373926
145MP0004145_abnormal_muscle_electrophysio0.60106793
146MP0000538_abnormal_urinary_bladder0.58256075
147MP0002837_dystrophic_cardiac_calcinosis0.55740753

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.95247066
2Persistence of primary teeth (HP:0006335)4.58895434
3Myokymia (HP:0002411)4.36139745
4Long palpebral fissure (HP:0000637)4.22763295
5Focal seizures (HP:0007359)4.01822604
6Conical tooth (HP:0000698)3.87086897
7Progressive cerebellar ataxia (HP:0002073)3.86445305
8Increased density of long bones (HP:0006392)3.57929341
9Narrow nasal bridge (HP:0000446)3.56343963
10Limb dystonia (HP:0002451)3.38312708
11Febrile seizures (HP:0002373)3.36615766
12Epileptic encephalopathy (HP:0200134)3.32162710
13Ankle contracture (HP:0006466)3.27683301
14Spinal cord lesions (HP:0100561)3.16838358
15Syringomyelia (HP:0003396)3.16838358
16Aplasia involving bones of the extremities (HP:0009825)3.14644258
17Aplasia involving bones of the upper limbs (HP:0009823)3.14644258
18Aplasia of the phalanges of the hand (HP:0009802)3.14644258
19Slow-growing hair (HP:0002217)3.14288321
20Abnormality of hair growth rate (HP:0011363)3.14288321
21Failure to thrive in infancy (HP:0001531)3.13925153
22Visual hallucinations (HP:0002367)3.09669927
23Polyphagia (HP:0002591)3.08214347
24Bilateral microphthalmos (HP:0007633)3.04429767
25Supranuclear gaze palsy (HP:0000605)2.99548708
26Premature rupture of membranes (HP:0001788)2.98922559
27Megalencephaly (HP:0001355)2.97562877
28Atonic seizures (HP:0010819)2.92773046
29Protrusio acetabuli (HP:0003179)2.92206152
30Tented upper lip vermilion (HP:0010804)2.86902574
31Amblyopia (HP:0000646)2.83293109
32Hand muscle atrophy (HP:0009130)2.82887034
33Spondylolisthesis (HP:0003302)2.81656334
34Absence seizures (HP:0002121)2.79993751
35Anosmia (HP:0000458)2.73986667
36Abnormality of binocular vision (HP:0011514)2.73272377
37Diplopia (HP:0000651)2.73272377
38Severe visual impairment (HP:0001141)2.73204384
39Generalized tonic-clonic seizures (HP:0002069)2.70716995
40Maternal diabetes (HP:0009800)2.68498812
41Abnormality of the pulmonary veins (HP:0011718)2.68338365
42Papilledema (HP:0001085)2.68090535
43Growth hormone deficiency (HP:0000824)2.67638628
44Abnormal eating behavior (HP:0100738)2.65089294
45Brittle hair (HP:0002299)2.64014513
46Spinal rigidity (HP:0003306)2.63818813
47Gastrointestinal stroma tumor (HP:0100723)2.62506001
48Upper limb amyotrophy (HP:0009129)2.62233589
49Distal upper limb amyotrophy (HP:0007149)2.62233589
50Hypotrichosis (HP:0001006)2.62055968
51Specific learning disability (HP:0001328)2.59685968
52Truncal ataxia (HP:0002078)2.58300991
53Genetic anticipation (HP:0003743)2.56833985
54Hypophosphatemic rickets (HP:0004912)2.55494391
55Retinal dysplasia (HP:0007973)2.54690116
56Premature loss of primary teeth (HP:0006323)2.54584805
57Congenital stationary night blindness (HP:0007642)2.54378002
58IgG deficiency (HP:0004315)2.52996001
59Short clavicles (HP:0000894)2.50353593
60Dialeptic seizures (HP:0011146)2.48424842
61Mutism (HP:0002300)2.43619196
62Ankle clonus (HP:0011448)2.42603460
63Anophthalmia (HP:0000528)2.40311705
64Septo-optic dysplasia (HP:0100842)2.39201998
65Depression (HP:0000716)2.36931068
66Abnormal number of incisors (HP:0011064)2.36585338
67Dry hair (HP:0011359)2.35787184
68Drooling (HP:0002307)2.35786166
69Excessive salivation (HP:0003781)2.35786166
70Thickened helices (HP:0000391)2.35245244
71Follicular hyperkeratosis (HP:0007502)2.34750467
72Abnormality of the phalanges of the hallux (HP:0010057)2.33903067
73Action tremor (HP:0002345)2.30983550
74Hemiparesis (HP:0001269)2.29217550
75Anomalous pulmonary venous return (HP:0010772)2.24814538
76Poor eye contact (HP:0000817)2.23799476
77Dysdiadochokinesis (HP:0002075)2.22840251
78Aplasia/Hypoplasia of the clavicles (HP:0006710)2.21262441
79Alacrima (HP:0000522)2.19886870
80Agitation (HP:0000713)2.19267108
81Lissencephaly (HP:0001339)2.18489468
82Urinary urgency (HP:0000012)2.18175434
83Hypoventilation (HP:0002791)2.17825349
84Broad-based gait (HP:0002136)2.17661751
85Abnormality of the aortic arch (HP:0012303)2.17279241
86Abnormality of the labia minora (HP:0012880)2.11504037
87Aortic dissection (HP:0002647)2.10516114
88Progressive inability to walk (HP:0002505)2.10381879
89Abnormality of dentin (HP:0010299)2.09339706
90Slender build (HP:0001533)2.08480566
91Concave nail (HP:0001598)2.07172181
92Achilles tendon contracture (HP:0001771)2.07078325
93Absent speech (HP:0001344)2.06153441
94Aplasia/Hypoplasia of the brainstem (HP:0007362)2.05667017
95Hypoplasia of the brainstem (HP:0002365)2.05667017
96Exotropia (HP:0000577)2.05520780
97Torticollis (HP:0000473)2.04872948
98Acanthosis nigricans (HP:0000956)2.04543653
99Pachygyria (HP:0001302)2.03023767
100Aplasia/Hypoplasia of the scapulae (HP:0006713)2.02703953
101Hypoplastic scapulae (HP:0000882)2.02703953
102Central scotoma (HP:0000603)2.00551719
103EEG with generalized epileptiform discharges (HP:0011198)2.00036927
104Abnormality of the middle phalanges of the toes (HP:0010183)1.99286484
105Epileptiform EEG discharges (HP:0011182)1.98153762
106Growth hormone excess (HP:0000845)1.97605017
107Neurofibrillary tangles (HP:0002185)1.97529738
108Truncal obesity (HP:0001956)1.97258749
109Esotropia (HP:0000565)1.96228379
110Abnormality of macular pigmentation (HP:0008002)1.96168320
111Keratoconus (HP:0000563)1.95594268
112Increased corneal curvature (HP:0100692)1.95594268
113Anterior segment dysgenesis (HP:0007700)1.94309997
114Abnormal social behavior (HP:0012433)1.93468444
115Impaired social interactions (HP:0000735)1.93468444
116Urinary bladder sphincter dysfunction (HP:0002839)1.93238340
117Morphological abnormality of the middle ear (HP:0008609)1.93211315
118Short nail (HP:0001799)1.92181448
119Anhidrosis (HP:0000970)1.92114362
120Wrist flexion contracture (HP:0001239)1.91291953
121Emphysema (HP:0002097)1.91124497
122Synostosis involving the elbow (HP:0003938)1.91054229
123Humeroradial synostosis (HP:0003041)1.91054229
124Aortic regurgitation (HP:0001659)1.90585534
125Spinal canal stenosis (HP:0003416)1.89854157
126Hypokinesia (HP:0002375)1.89614623
127Gait imbalance (HP:0002141)1.88946832
128Abnormality of salivation (HP:0100755)1.88798788
129Anxiety (HP:0000739)1.86589433
130Hydroureter (HP:0000072)1.86330298
131Dysmetria (HP:0001310)1.85950537
132Pheochromocytoma (HP:0002666)1.85936911
133Vertebral compression fractures (HP:0002953)1.85884797
134Nuclear cataract (HP:0100018)1.84441721
135Scanning speech (HP:0002168)1.83235136
136Abnormality of the fetal cardiovascular system (HP:0010948)1.81741155
137Abnormal umbilical cord blood vessels (HP:0011403)1.81741155
138Single umbilical artery (HP:0001195)1.81741155
139Insomnia (HP:0100785)1.80632138
140Severe combined immunodeficiency (HP:0004430)1.80042437
141Hemiplegia (HP:0002301)1.79906740
142Hypsarrhythmia (HP:0002521)1.79289216
143Deep palmar crease (HP:0006191)1.79153239
144Hypophosphatemia (HP:0002148)1.78768361
145Aplasia/Hypoplasia of the lens (HP:0008063)1.78340639
146Decreased central vision (HP:0007663)1.76228112
147Spastic gait (HP:0002064)1.75884085
148Radial bowing (HP:0002986)1.75612745
149Abnormality of chromosome segregation (HP:0002916)1.74807013
150Peripheral hypomyelination (HP:0007182)1.73396083
151Abnormal hair whorl (HP:0010721)1.73196508
152Decreased lacrimation (HP:0000633)1.72393653
153Short tibia (HP:0005736)1.71750121
154Supernumerary bones of the axial skeleton (HP:0009144)1.70546645
155Wormian bones (HP:0002645)1.69854667
156Precocious puberty (HP:0000826)1.69182782
157Upper limb muscle weakness (HP:0003484)1.68092577
158Congenital primary aphakia (HP:0007707)1.67710214
159Pointed chin (HP:0000307)1.67568160
160Hyperacusis (HP:0010780)1.67497253
161Sleep apnea (HP:0010535)1.66945312
162Bladder diverticulum (HP:0000015)1.66552512
163Preauricular pit (HP:0004467)1.66110953
164Periauricular skin pits (HP:0100277)1.66110953
165Porencephaly (HP:0002132)1.66105250
166Cortical dysplasia (HP:0002539)1.65945384
167Metaphyseal dysplasia (HP:0100255)1.65589268
168Recurrent bronchitis (HP:0002837)1.65418194
169Aqueductal stenosis (HP:0002410)1.65338448
170Narrow chest (HP:0000774)1.64546033
171Inability to walk (HP:0002540)1.63977373
172Bowing of the arm (HP:0006488)1.63697604
173Bowed forearm bones (HP:0003956)1.63697604
174Preaxial foot polydactyly (HP:0001841)1.63619695
175Cerebral inclusion bodies (HP:0100314)1.63448140
176Hyperthyroidism (HP:0000836)1.63249980
177Abnormality of the anterior chamber (HP:0000593)1.62558975
178Ulnar bowing (HP:0003031)1.62228982
179Entropion (HP:0000621)1.60383369
180Insulin resistance (HP:0000855)1.59664940
181Fatigue (HP:0012378)1.58083174
182Vascular tortuosity (HP:0004948)1.58070890
183Hypoplasia of the uterus (HP:0000013)1.58041466
184Supernumerary ribs (HP:0005815)1.56255718
185Camptodactyly of toe (HP:0001836)1.55952222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK35.05391529
2KSR13.74953740
3MARK13.51772938
4MAP3K143.47139807
5NTRK33.35748294
6MINK13.15164224
7NTRK22.91872612
8MAP3K42.90846527
9MAP3K92.86208939
10MAP3K132.77558992
11BCR2.61974333
12TESK22.50991880
13UHMK12.44429606
14MAP2K72.40259308
15EPHB22.17579094
16MAP3K122.05820826
17PAK61.99144515
18IRAK21.93258424
19MOS1.87411226
20MAP2K21.79919483
21BUB11.78355282
22NTRK11.75625902
23TXK1.75400370
24TAF11.72912965
25CASK1.62455580
26MAPK131.58152344
27MAP2K41.55953259
28STK161.52024321
29PNCK1.51295386
30SIK21.45280095
31IKBKE1.44537470
32TBK11.41125272
33TAOK21.37424351
34AURKA1.35006857
35GRK51.32431377
36EPHA41.27313440
37CAMK1G1.27048841
38CDK51.26787465
39DAPK21.25991643
40CDK181.23138912
41WNK41.21346521
42TYRO31.18189540
43GRK61.16551713
44EIF2AK21.14514472
45FES1.12106887
46TLK11.11921036
47TNIK1.10525021
48BRAF1.10432669
49EPHB11.08142907
50STK391.07364686
51JAK11.06949304
52CDK141.03403624
53CDK150.96788875
54TAOK30.96752234
55SIK10.93633660
56CDK190.93222250
57DAPK10.93182766
58PRKCG0.93031027
59TESK10.93029479
60CHUK0.92368361
61PRPF4B0.92348807
62FGFR20.92012416
63KSR20.91620902
64PTK20.90419380
65IKBKB0.89329776
66PAK30.88759789
67PHKG10.88668709
68PHKG20.88668709
69DYRK1A0.86608658
70WNK30.86175510
71CDK90.86132603
72SGK4940.85283374
73SGK2230.85283374
74CDK11A0.84810104
75DYRK20.84560671
76CAMK2A0.82913025
77BLK0.82399381
78ICK0.81645810
79IRAK10.80802425
80FER0.80405606
81ERBB30.79888628
82CSNK1G20.79440177
83PRKCI0.78066414
84ERBB20.77538921
85ERN10.77313170
86CDK70.74752812
87ERBB40.74157639
88LIMK10.73850868
89TNK20.70863118
90RAF10.68756824
91PRKD20.68626543
92TRIB30.67835420
93DMPK0.67725544
94PRKCZ0.67185445
95MAPK40.66155796
96ROCK20.66153713
97RET0.65733893
98FGFR30.65699095
99STK380.65545342
100NEK90.63070629
101PAK20.62601397
102CAMK10.61182665
103PLK20.61100229
104CAMK1D0.60327818
105FGFR10.60237902
106CHEK20.59097483
107MAP4K10.58636273
108LATS20.57959747
109CSNK1G30.56168832
110RIPK40.55310732
111MAPK100.55044188
112STK110.55000659
113BCKDK0.53414757
114MAPK110.53374931
115ROCK10.51191101
116FYN0.50871629
117PDGFRA0.49303237
118CAMK2B0.48436948
119TAOK10.48291476
120PRKCH0.47079319
121PAK10.46869038
122PRKCE0.46011292
123NME10.45951821
124GRK70.45849945
125MAPK90.45736202
126PRKCQ0.45028971
127ARAF0.44238141
128CAMKK10.44136740
129BMPR1B0.43708654
130DDR20.43230379
131SGK20.42668907
132LMTK20.42664132
133MAP2K10.42210847
134PRKD30.41617054
135CDC42BPA0.39907832
136MAPK70.39290251
137MAP3K110.39074222
138VRK20.37701553
139MAP3K70.37188221
140CAMK2D0.36954462
141SGK10.35399939
142PRKG10.35181622
143CDK80.34616869
144IRAK30.33937327
145RPS6KA30.33928952
146STK100.33648116
147KDR0.33162784
148MARK20.32753704
149MAP3K80.31279885
150INSRR0.30198505
151PRKCB0.30128504
152FGR0.30099391
153CSNK1A1L0.29673239
154EPHA20.29250091
155KIT0.28610074
156RPS6KA20.28380850
157MAPKAPK50.28359885
158MAP3K100.27287862
159MAPK30.26727831

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.76420449
2Nicotine addiction_Homo sapiens_hsa050333.88823407
3Synaptic vesicle cycle_Homo sapiens_hsa047213.35925863
4GABAergic synapse_Homo sapiens_hsa047273.00655643
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.80530820
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.57532215
7Morphine addiction_Homo sapiens_hsa050322.50157199
8Circadian entrainment_Homo sapiens_hsa047132.30034129
9Glutamatergic synapse_Homo sapiens_hsa047242.25401565
10Olfactory transduction_Homo sapiens_hsa047402.20592118
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20267916
12Dopaminergic synapse_Homo sapiens_hsa047282.15367116
13Basal transcription factors_Homo sapiens_hsa030222.07646165
14Cocaine addiction_Homo sapiens_hsa050302.00043563
15Serotonergic synapse_Homo sapiens_hsa047261.96495586
16Insulin secretion_Homo sapiens_hsa049111.90600251
17Amphetamine addiction_Homo sapiens_hsa050311.87357713
18Salivary secretion_Homo sapiens_hsa049701.78031460
19Taste transduction_Homo sapiens_hsa047421.75338844
20Cholinergic synapse_Homo sapiens_hsa047251.72703107
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.70478861
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70225116
23Axon guidance_Homo sapiens_hsa043601.69415289
24Hedgehog signaling pathway_Homo sapiens_hsa043401.62788364
25Long-term potentiation_Homo sapiens_hsa047201.61495691
26Basal cell carcinoma_Homo sapiens_hsa052171.56488298
27Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53861939
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52936903
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.46147491
30B cell receptor signaling pathway_Homo sapiens_hsa046621.43765787
31Collecting duct acid secretion_Homo sapiens_hsa049661.39990596
32Primary immunodeficiency_Homo sapiens_hsa053401.37286789
33Gap junction_Homo sapiens_hsa045401.35773003
34Renin secretion_Homo sapiens_hsa049241.34995610
35Gastric acid secretion_Homo sapiens_hsa049711.34755121
36Melanogenesis_Homo sapiens_hsa049161.33973254
37Oxytocin signaling pathway_Homo sapiens_hsa049211.33121495
38Ovarian steroidogenesis_Homo sapiens_hsa049131.32062200
39Long-term depression_Homo sapiens_hsa047301.31930428
40Cardiac muscle contraction_Homo sapiens_hsa042601.29214720
41Shigellosis_Homo sapiens_hsa051311.25880371
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.25094325
43Calcium signaling pathway_Homo sapiens_hsa040201.20582011
44Non-small cell lung cancer_Homo sapiens_hsa052231.18833913
45Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.15059693
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14695470
47Dorso-ventral axis formation_Homo sapiens_hsa043201.13308059
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11762536
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.09975602
50GnRH signaling pathway_Homo sapiens_hsa049121.08915267
51Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07755741
52Type II diabetes mellitus_Homo sapiens_hsa049301.07168458
53Viral carcinogenesis_Homo sapiens_hsa052031.04605564
54Intestinal immune network for IgA production_Homo sapiens_hsa046721.04339843
55Vibrio cholerae infection_Homo sapiens_hsa051101.03755933
56Phototransduction_Homo sapiens_hsa047441.03523882
57cAMP signaling pathway_Homo sapiens_hsa040241.02968884
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02374901
59ErbB signaling pathway_Homo sapiens_hsa040121.00550788
60Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.98932583
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.97330822
62Phenylalanine metabolism_Homo sapiens_hsa003600.96702755
63Apoptosis_Homo sapiens_hsa042100.95138953
64Hepatitis B_Homo sapiens_hsa051610.94994680
65Wnt signaling pathway_Homo sapiens_hsa043100.93022474
66Oocyte meiosis_Homo sapiens_hsa041140.90925683
67Prolactin signaling pathway_Homo sapiens_hsa049170.89369388
68Measles_Homo sapiens_hsa051620.87243811
69Estrogen signaling pathway_Homo sapiens_hsa049150.86891687
70TNF signaling pathway_Homo sapiens_hsa046680.86623477
71Bladder cancer_Homo sapiens_hsa052190.82624104
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80469800
73Focal adhesion_Homo sapiens_hsa045100.79621929
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79536202
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.78856856
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.78641234
77Small cell lung cancer_Homo sapiens_hsa052220.77580040
78Dilated cardiomyopathy_Homo sapiens_hsa054140.75943934
79Renal cell carcinoma_Homo sapiens_hsa052110.75696766
80p53 signaling pathway_Homo sapiens_hsa041150.74900087
81Prion diseases_Homo sapiens_hsa050200.73324173
82Choline metabolism in cancer_Homo sapiens_hsa052310.73300526
83Hippo signaling pathway_Homo sapiens_hsa043900.73121398
84Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72662693
85Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71517923
86MAPK signaling pathway_Homo sapiens_hsa040100.71096268
87Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.70271075
88Circadian rhythm_Homo sapiens_hsa047100.69966072
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.69506696
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.69413985
91Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68588505
92Glioma_Homo sapiens_hsa052140.66022592
93Alcoholism_Homo sapiens_hsa050340.64365315
94Epstein-Barr virus infection_Homo sapiens_hsa051690.64358696
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.64167556
96MicroRNAs in cancer_Homo sapiens_hsa052060.64150035
97Notch signaling pathway_Homo sapiens_hsa043300.63356728
98Cell cycle_Homo sapiens_hsa041100.63075058
99Colorectal cancer_Homo sapiens_hsa052100.62808514
100Ras signaling pathway_Homo sapiens_hsa040140.60314913
101HTLV-I infection_Homo sapiens_hsa051660.59785784
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.59724789
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.58845184
104Type I diabetes mellitus_Homo sapiens_hsa049400.58347450
105Chronic myeloid leukemia_Homo sapiens_hsa052200.57949195
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57644447
107ECM-receptor interaction_Homo sapiens_hsa045120.57356131
108Pancreatic secretion_Homo sapiens_hsa049720.55096604
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.53937446
110Thyroid hormone synthesis_Homo sapiens_hsa049180.53338406
111Endocytosis_Homo sapiens_hsa041440.52592478
112Proteoglycans in cancer_Homo sapiens_hsa052050.52475285
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.52310416
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.52280147
115Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52156901
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51733837
117Acute myeloid leukemia_Homo sapiens_hsa052210.51604845
118Herpes simplex infection_Homo sapiens_hsa051680.51292342
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51019248
120Rap1 signaling pathway_Homo sapiens_hsa040150.50756583
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.49916105
122Prostate cancer_Homo sapiens_hsa052150.49499010
123Sphingolipid signaling pathway_Homo sapiens_hsa040710.46887756
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45307154
125Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44687447
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.44240568
127Endometrial cancer_Homo sapiens_hsa052130.43374725
128Alzheimers disease_Homo sapiens_hsa050100.43106584
129Oxidative phosphorylation_Homo sapiens_hsa001900.42682522
130Parkinsons disease_Homo sapiens_hsa050120.39571074
131VEGF signaling pathway_Homo sapiens_hsa043700.38185616
132Phagosome_Homo sapiens_hsa041450.37719899
133Asthma_Homo sapiens_hsa053100.37028709
134Insulin signaling pathway_Homo sapiens_hsa049100.36711772
135T cell receptor signaling pathway_Homo sapiens_hsa046600.36657719
136Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36578857
137Inositol phosphate metabolism_Homo sapiens_hsa005620.35687075
138Glucagon signaling pathway_Homo sapiens_hsa049220.34446655
139Chemokine signaling pathway_Homo sapiens_hsa040620.30811054
140Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.28362448

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