TOR1AIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1collecting duct development (GO:0072044)7.09172844
2metanephric tubule development (GO:0072170)7.08913611
3metanephric nephron tubule development (GO:0072234)7.08913611
4metanephric nephron epithelium development (GO:0072243)6.40537173
5metanephric epithelium development (GO:0072207)5.83606445
6viral transcription (GO:0019083)5.76809419
7translational termination (GO:0006415)5.59462696
8maternal placenta development (GO:0001893)5.16467699
9maturation of SSU-rRNA (GO:0030490)5.06543256
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.04362029
11positive regulation of gamma-delta T cell activation (GO:0046645)4.95668119
12negative regulation of execution phase of apoptosis (GO:1900118)4.93589613
13ribosomal large subunit biogenesis (GO:0042273)4.92230509
14negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.74952109
15negative regulation of cell killing (GO:0031342)4.74952109
16retina layer formation (GO:0010842)4.72310669
17spliceosomal complex assembly (GO:0000245)4.66168268
18translational elongation (GO:0006414)4.63977646
19positive regulation of protein kinase C signaling (GO:0090037)4.62823168
20nephron tubule development (GO:0072080)4.62302997
21SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.59111004
22translational initiation (GO:0006413)4.55454123
23cotranslational protein targeting to membrane (GO:0006613)4.52058866
24protein targeting to ER (GO:0045047)4.51646144
25regulation of B cell receptor signaling pathway (GO:0050855)4.49308091
26spliceosomal snRNP assembly (GO:0000387)4.49191624
27GMP metabolic process (GO:0046037)4.40785785
28response to interleukin-15 (GO:0070672)4.38909769
29cellular response to interleukin-15 (GO:0071350)4.38573841
30DNA deamination (GO:0045006)4.31817531
31establishment of protein localization to endoplasmic reticulum (GO:0072599)4.30295872
32nephron epithelium development (GO:0072009)4.25259838
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.25026757
34cellular protein complex disassembly (GO:0043624)4.16180886
35regulation of gamma-delta T cell differentiation (GO:0045586)4.15373473
36proteasome assembly (GO:0043248)4.13077983
37protein localization to endoplasmic reticulum (GO:0070972)4.12871745
38viral life cycle (GO:0019058)4.08147238
39antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.07684723
40DNA replication checkpoint (GO:0000076)4.06407456
41regulation of gamma-delta T cell activation (GO:0046643)4.03643955
42renal tubule development (GO:0061326)4.01306508
43DNA damage response, detection of DNA damage (GO:0042769)3.95319633
44negative regulation of T cell mediated immunity (GO:0002710)3.94490178
45antigen processing and presentation of endogenous antigen (GO:0019883)3.90551936
46positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.88812039
47protein complex disassembly (GO:0043241)3.87872478
48negative regulation of Ras GTPase activity (GO:0034261)3.80740722
49ribosomal small subunit biogenesis (GO:0042274)3.80274869
50negative T cell selection (GO:0043383)3.77440068
51negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.75801503
52regulation of posttranscriptional gene silencing (GO:0060147)3.75770265
53regulation of gene silencing by miRNA (GO:0060964)3.75770265
54regulation of gene silencing by RNA (GO:0060966)3.75770265
55macromolecular complex disassembly (GO:0032984)3.73624469
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61420788
57peptidyl-arginine omega-N-methylation (GO:0035247)3.57609310
58negative thymic T cell selection (GO:0045060)3.57390372
59cellular extravasation (GO:0045123)3.57233858
60negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.50088795
61tRNA methylation (GO:0030488)3.47973681
62neutrophil activation involved in immune response (GO:0002283)3.44954021
63negative regulation of lymphocyte mediated immunity (GO:0002707)3.44425726
64central nervous system myelination (GO:0022010)3.44069109
65axon ensheathment in central nervous system (GO:0032291)3.44069109
66glycine metabolic process (GO:0006544)3.43630849
67viral mRNA export from host cell nucleus (GO:0046784)3.41456545
68eyelid development in camera-type eye (GO:0061029)3.36852116
69pseudouridine synthesis (GO:0001522)3.36591395
70DNA unwinding involved in DNA replication (GO:0006268)3.34982082
71termination of RNA polymerase III transcription (GO:0006386)3.34759200
72transcription elongation from RNA polymerase III promoter (GO:0006385)3.34759200
73DNA replication initiation (GO:0006270)3.32846849
74positive regulation of T cell mediated cytotoxicity (GO:0001916)3.27486963
75DNA replication-dependent nucleosome assembly (GO:0006335)3.27455517
76DNA replication-dependent nucleosome organization (GO:0034723)3.27455517
77regulation of regulatory T cell differentiation (GO:0045589)3.25662848
78ribonucleoprotein complex biogenesis (GO:0022613)3.24419924
79interkinetic nuclear migration (GO:0022027)3.24065504
80regulation of T cell mediated cytotoxicity (GO:0001914)3.23693490
81negative regulation of interleukin-12 production (GO:0032695)3.19467066
82detection of other organism (GO:0098543)3.17601453
83translation (GO:0006412)3.16008284
84negative regulation of DNA-templated transcription, elongation (GO:0032785)3.14961215
85negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.14961215
86G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.14729108
87negative regulation of GTPase activity (GO:0034260)3.13200827
88negative regulation of GTP catabolic process (GO:0033125)3.13200827
89regulation of alpha-beta T cell proliferation (GO:0046640)3.10836025
90negative regulation of T-helper cell differentiation (GO:0045623)3.10834317
91negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.10834317
92detection of molecule of bacterial origin (GO:0032490)3.10185230
93neutrophil activation (GO:0042119)3.08651619
94T cell migration (GO:0072678)3.08101147
95intra-S DNA damage checkpoint (GO:0031573)3.07406900
96nuclear-transcribed mRNA catabolic process (GO:0000956)3.06944908
97face development (GO:0060324)3.06509390
98regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.04636242
99hepatocyte apoptotic process (GO:0097284)3.04485824
100positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03250181
101interferon-gamma production (GO:0032609)3.02220037
102UTP biosynthetic process (GO:0006228)3.01621207
103negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.01337253
104regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.98740696
105regulation of B cell differentiation (GO:0045577)2.97703206
106GTP biosynthetic process (GO:0006183)2.97095807
107mesenchymal cell proliferation (GO:0010463)2.96974065
108DNA strand elongation involved in DNA replication (GO:0006271)2.96536844
109positive regulation of tolerance induction (GO:0002645)2.96289355
110protein complex localization (GO:0031503)2.94928165
111response to peptidoglycan (GO:0032494)2.94851147
112positive regulation by symbiont of host defense response (GO:0052509)2.93953330
113modulation by symbiont of host defense response (GO:0052031)2.93953330
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.93953330
115modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.93953330
116positive regulation by organism of defense response of other organism involved in symbiotic interact2.93953330
117modulation by symbiont of host immune response (GO:0052553)2.93953330
118positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.93840604
119mRNA catabolic process (GO:0006402)2.93786770
120growth hormone receptor signaling pathway (GO:0060396)2.93471462
121negative regulation of leukocyte mediated immunity (GO:0002704)2.93438898
122rRNA processing (GO:0006364)2.92808325
123ncRNA 3-end processing (GO:0043628)2.91075610
124positive regulation of B cell differentiation (GO:0045579)2.89264867
125neutrophil mediated immunity (GO:0002446)2.88443175
126branch elongation of an epithelium (GO:0060602)2.88408627
127RNA catabolic process (GO:0006401)2.87474512
128leukocyte aggregation (GO:0070486)2.87451556
129T cell selection (GO:0045058)2.87449276
130positive T cell selection (GO:0043368)2.86713563
131tolerance induction (GO:0002507)2.86310220
132granulocyte activation (GO:0036230)2.86305990
133regulation of somitogenesis (GO:0014807)2.85463471
134negative regulation of adaptive immune response (GO:0002820)2.84493144
135detection of external biotic stimulus (GO:0098581)2.84306943
136melanin metabolic process (GO:0006582)2.83904188
137regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.83902536
138positive thymic T cell selection (GO:0045059)2.82762575
139rRNA metabolic process (GO:0016072)2.82314619
140protein targeting to membrane (GO:0006612)2.79766509
141detection of bacterium (GO:0016045)2.79305863
142pattern specification involved in kidney development (GO:0061004)2.78871142
143peptidyl-arginine N-methylation (GO:0035246)2.77360097
144peptidyl-arginine methylation (GO:0018216)2.77360097
145macrophage activation involved in immune response (GO:0002281)2.77195468
146regulation of interleukin-12 biosynthetic process (GO:0045075)2.77043255
147regulation of tolerance induction (GO:0002643)2.76191293
148postsynaptic membrane organization (GO:0001941)2.76021931
149histone arginine methylation (GO:0034969)2.75680333
150antigen processing and presentation via MHC class Ib (GO:0002475)2.74679291
151viral genome replication (GO:0019079)2.74111807
152positive regulation of granulocyte differentiation (GO:0030854)2.72475843
153formation of translation preinitiation complex (GO:0001731)2.71850366
154lateral sprouting from an epithelium (GO:0060601)2.70355519
155regulation of interferon-beta biosynthetic process (GO:0045357)2.69264913
156DNA strand elongation (GO:0022616)2.69064723
157RNA splicing, via transesterification reactions (GO:0000375)2.68958048
158melanin biosynthetic process (GO:0042438)2.68862314
159regulation of T cell tolerance induction (GO:0002664)2.68166717
160presynaptic membrane assembly (GO:0097105)2.68149451
161axis elongation (GO:0003401)2.66798841
162regulation of protein kinase C signaling (GO:0090036)2.66578318
163mRNA splicing, via spliceosome (GO:0000398)2.66356097
164RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66356097
165cellular response to nitric oxide (GO:0071732)2.66176604
166B cell receptor signaling pathway (GO:0050853)2.66158850
167positive regulation of gastrulation (GO:2000543)2.65395902
168cellular response to type I interferon (GO:0071357)2.65331137
169type I interferon signaling pathway (GO:0060337)2.65331137
170production of molecular mediator involved in inflammatory response (GO:0002532)2.64386851
171thymic T cell selection (GO:0045061)2.63701776
172regulation of leukocyte mediated cytotoxicity (GO:0001910)2.63216848
173dendritic cell migration (GO:0036336)2.62837818
174response to type I interferon (GO:0034340)2.62377286
175regulation of necroptotic process (GO:0060544)2.61651990
176positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.60549235
177negative regulation of complement activation (GO:0045916)2.59630833
178myeloid cell activation involved in immune response (GO:0002275)2.59534888
179positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.59465212
180positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.58157451
181regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.56372826
182regulation of natural killer cell mediated immunity (GO:0002715)2.56372826
183cellular response to growth hormone stimulus (GO:0071378)2.55684793
184JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.54027920
185leukocyte degranulation (GO:0043299)2.53718611
186lymphocyte chemotaxis (GO:0048247)2.51451910
187dendritic cell chemotaxis (GO:0002407)2.50331876
188negative regulation of humoral immune response (GO:0002921)2.49335734
189negative regulation of B cell proliferation (GO:0030889)2.48125443
190negative regulation of glycoprotein biosynthetic process (GO:0010561)2.47647540
191response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.43687660
192response to host immune response (GO:0052572)2.43687660
193iron ion import (GO:0097286)2.42254601
194positive regulation of T cell mediated immunity (GO:0002711)2.41766627
195macrophage activation (GO:0042116)2.41698728
196response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.41283570
197response to host (GO:0075136)2.41283570
198response to host defenses (GO:0052200)2.41283570
199cellular response to ethanol (GO:0071361)2.41244085
200short-term memory (GO:0007614)12.4854061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.99007461
2E2F7_22180533_ChIP-Seq_HELA_Human5.33365897
3* IRF8_22096565_ChIP-ChIP_GC-B_Human5.29288385
4SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.67435188
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.31847696
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.21454054
7STAT6_21828071_ChIP-Seq_BEAS2B_Human4.17239833
8MYC_18555785_ChIP-Seq_MESCs_Mouse4.04956505
9* ETS1_20019798_ChIP-Seq_JURKAT_Human3.32976583
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.07582134
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.04451923
12SMAD_19615063_ChIP-ChIP_OVARY_Human3.01293251
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.92976123
14MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.91540831
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.83573943
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.82326712
17RUNX_20019798_ChIP-Seq_JUKART_Human2.79898640
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.73988219
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.72067561
20* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.68775914
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66670627
22* MYB_26560356_Chip-Seq_TH2_Human2.61671075
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.60647694
24* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.59220759
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.58001416
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.57742973
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55366456
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.55197107
29* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.54408438
30* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.52988486
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.48638403
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46092365
33E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.42725417
34KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.41286466
35KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.41286466
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.41286466
37EST1_17652178_ChIP-ChIP_JURKAT_Human2.41274963
38CREB1_15753290_ChIP-ChIP_HEK293T_Human2.40784582
39XRN2_22483619_ChIP-Seq_HELA_Human2.34374004
40KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.34088878
41* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.23616567
42Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.23378716
43* TTF2_22483619_ChIP-Seq_HELA_Human2.20936120
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.12957921
45* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.09378036
46TRIM28_21343339_ChIP-Seq_HEK293_Human2.05272786
47* MYB_26560356_Chip-Seq_TH1_Human2.02426022
48GABP_17652178_ChIP-ChIP_JURKAT_Human1.99375305
49* SPI1_23547873_ChIP-Seq_NB4_Human1.98435431
50POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.98141061
51TCF3_18692474_ChIP-Seq_MEFs_Mouse1.92817210
52GATA1_22025678_ChIP-Seq_K562_Human1.91683922
53* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91512947
54NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90766180
55* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.87753926
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.87214358
57* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85428295
58GATA2_21666600_ChIP-Seq_HMVEC_Human1.85226221
59GATA3_27048872_Chip-Seq_THYMUS_Human1.82518259
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.76349369
61SCL_19346495_ChIP-Seq_HPC-7_Human1.70832032
62HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70772895
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69617012
64GATA3_26560356_Chip-Seq_TH2_Human1.68805190
65MYC_18940864_ChIP-ChIP_HL60_Human1.67138856
66ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.65916948
67VDR_24787735_ChIP-Seq_THP-1_Human1.62358570
68* MAF_26560356_Chip-Seq_TH1_Human1.58616560
69* SPI1_23127762_ChIP-Seq_K562_Human1.58438086
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58430240
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.56475012
72* YY1_21170310_ChIP-Seq_MESCs_Mouse1.56174047
73VDR_22108803_ChIP-Seq_LS180_Human1.54811244
74CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53743567
75* PU_27001747_Chip-Seq_BMDM_Mouse1.51334873
76MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51328410
77* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.51217373
78RUNX1_22412390_ChIP-Seq_EML_Mouse1.49331037
79TCF3_18692474_ChIP-Seq_MESCs_Mouse1.48619448
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.44892568
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.44494358
82DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.44360674
83* DCP1A_22483619_ChIP-Seq_HELA_Human1.43726902
84SOX2_18692474_ChIP-Seq_MEFs_Mouse1.43336560
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.43307368
86AR_21572438_ChIP-Seq_LNCaP_Human1.42699692
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41884763
88VDR_23849224_ChIP-Seq_CD4+_Human1.41751774
89POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40599524
90CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.39985917
91STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.39766644
92RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.38092835
93EZH2_22144423_ChIP-Seq_EOC_Human1.37627339
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.35731259
95POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.34584068
96* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.33957722
97GABP_19822575_ChIP-Seq_HepG2_Human1.33362510
98CIITA_25753668_ChIP-Seq_RAJI_Human1.32551780
99PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32340981
100PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31913621
101ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31018784
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.30622505
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29159114
104RBPJ_22232070_ChIP-Seq_NCS_Mouse1.27001339
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.26390240
106E2F1_21310950_ChIP-Seq_MCF-7_Human1.26310659
107VDR_24763502_ChIP-Seq_THP-1_Human1.23478617
108TFEB_21752829_ChIP-Seq_HELA_Human1.23144349
109AR_21909140_ChIP-Seq_LNCAP_Human1.22848697
110ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22829937
111PKCTHETA_26484144_Chip-Seq_BREAST_Human1.22362372
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.20601337
113LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20326550
114* FOXP1_21924763_ChIP-Seq_HESCs_Human1.19411542
115KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18768588
116SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18746664
117* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18690313
118ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.18003401
119LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17699043
120VDR_21846776_ChIP-Seq_THP-1_Human1.17296243
121* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.16456932
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15256626
123TP63_19390658_ChIP-ChIP_HaCaT_Human1.14439925
124EED_16625203_ChIP-ChIP_MESCs_Mouse1.13314522
125ERG_21242973_ChIP-ChIP_JURKAT_Human1.11976183
126* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11888482
127* UTX_26944678_Chip-Seq_JUKART_Human1.11793199
128FOXP3_21729870_ChIP-Seq_TREG_Human1.11618735
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11282768
130SA1_27219007_Chip-Seq_ERYTHROID_Human1.09591306
131POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.08671526
132ELK1_22589737_ChIP-Seq_MCF10A_Human1.08460048
133NANOG_18555785_ChIP-Seq_MESCs_Mouse1.07245353
134* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.06916569
135* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.06916569
136* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.06576875
137CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05628543
138* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04890985
139SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04793820
140YY1_22570637_ChIP-Seq_MALME-3M_Human1.04775543
141TET1_21451524_ChIP-Seq_MESCs_Mouse1.04044086
142NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.03953452
143* EZH2_27294783_Chip-Seq_NPCs_Mouse1.03546692
144TP53_20018659_ChIP-ChIP_R1E_Mouse1.03117099
145* BRD4_25478319_ChIP-Seq_HGPS_Human1.01905914
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01499594
147* NFE2_27457419_Chip-Seq_LIVER_Mouse0.99966649
148SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99372455
149CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.98388487
150FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98209720
151FLI1_27457419_Chip-Seq_LIVER_Mouse0.97710275
152JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96876353
153STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.96660564
154* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96636687
155PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.96612544
156SOX2_18692474_ChIP-Seq_MESCs_Mouse0.95583331
157* SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.95373473
158MAF_26560356_Chip-Seq_TH2_Human0.94608162
159YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94376854
160FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.94266253
161SOX2_16153702_ChIP-ChIP_HESCs_Human0.93921427
162STAT1_20625510_ChIP-Seq_HELA_Human0.93779646
163NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.93354135
164CDX2_19796622_ChIP-Seq_MESCs_Mouse0.93041014
165NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92828672
166VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.92055098
167RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91740885
168JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90993259
169PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.90702578
170GATA1_19941827_ChIP-Seq_MEL_Mouse0.90616056
171MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.90170783
172CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89614907
173CBX2_27304074_Chip-Seq_ESCs_Mouse0.89601189
174GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89295293
175CJUN_26792858_Chip-Seq_BT549_Human0.88269056
176CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88202091
177LXR_22292898_ChIP-Seq_THP-1_Human0.88114086
178ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87586579
179EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.87186190
180RING1B_27294783_Chip-Seq_NPCs_Mouse0.85548759
181SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85433224
182HOXB4_20404135_ChIP-ChIP_EML_Mouse0.84907597
183ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84813505
184PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83877554
185PCGF2_27294783_Chip-Seq_ESCs_Mouse0.83115445
186GATA3_26560356_Chip-Seq_TH1_Human0.82549657
187* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82322290
188* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.81975214
189CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81834158
190EGR1_23403033_ChIP-Seq_LIVER_Mouse0.81533889
191* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.81462252
192TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81228429
193* CRX_20693478_ChIP-Seq_RETINA_Mouse0.80233365
194CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79960094
195SALL4_22934838_ChIP-ChIP_CD34+_Human0.79735366
196EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78191496
197PPAR_26484153_Chip-Seq_NCI-H1993_Human0.78184772

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color6.55864593
2MP0005409_darkened_coat_color3.89191987
3MP0004381_abnormal_hair_follicle3.86671734
4MP0001835_abnormal_antigen_presentation3.20726733
5MP0003011_delayed_dark_adaptation3.18613855
6MP0003724_increased_susceptibility_to3.14146509
7MP0003436_decreased_susceptibility_to2.76831145
8MP0004742_abnormal_vestibular_system2.73977272
9MP0003315_abnormal_perineum_morphology2.68004259
10MP0001188_hyperpigmentation2.67650250
11MP0009379_abnormal_foot_pigmentation2.59840287
12MP0003763_abnormal_thymus_physiology2.56409805
13MP0000685_abnormal_immune_system2.56037049
14MP0005671_abnormal_response_to2.49281704
15MP0006292_abnormal_olfactory_placode2.48763578
16MP0008932_abnormal_embryonic_tissue2.46571172
17MP0003693_abnormal_embryo_hatching2.42771937
18MP0000049_abnormal_middle_ear2.32440611
19MP0002419_abnormal_innate_immunity2.27166650
20MP0005000_abnormal_immune_tolerance2.24803848
21MP0003300_gastrointestinal_ulcer2.24490405
22MP0001800_abnormal_humoral_immune2.23112001
23MP0009785_altered_susceptibility_to2.19515337
24MP0002249_abnormal_larynx_morphology2.16873693
25MP0000428_abnormal_craniofacial_morphol2.14856826
26MP0003828_pulmonary_edema2.05794951
27MP0005387_immune_system_phenotype2.04306079
28MP0001790_abnormal_immune_system2.04306079
29MP0002148_abnormal_hypersensitivity_rea2.04122132
30MP0009250_abnormal_appendicular_skeleto2.03698549
31MP0003191_abnormal_cellular_cholesterol2.03654684
32MP0002166_altered_tumor_susceptibility2.02019239
33MP0006082_CNS_inflammation1.99314149
34MP0002723_abnormal_immune_serum1.98544492
35MP0005025_abnormal_response_to1.98433886
36MP0004957_abnormal_blastocyst_morpholog1.98218532
37MP0002452_abnormal_antigen_presenting1.96304238
38MP0002653_abnormal_ependyma_morphology1.95750382
39MP0010030_abnormal_orbit_morphology1.94851572
40MP0003385_abnormal_body_wall1.94563531
41MP0005257_abnormal_intraocular_pressure1.93312539
42MP0002420_abnormal_adaptive_immunity1.90287587
43MP0003938_abnormal_ear_development1.89621838
44MP0001819_abnormal_immune_cell1.87374292
45MP0003937_abnormal_limbs/digits/tail_de1.84629921
46MP0002877_abnormal_melanocyte_morpholog1.83207394
47MP0002282_abnormal_trachea_morphology1.78321414
48MP0002405_respiratory_system_inflammati1.74395872
49MP0003880_abnormal_central_pattern1.72915258
50MP0003303_peritoneal_inflammation1.72539066
51MP0001533_abnormal_skeleton_physiology1.70057082
52MP0004133_heterotaxia1.68531517
53MP0002751_abnormal_autonomic_nervous1.61421783
54MP0000537_abnormal_urethra_morphology1.60975273
55MP0000465_gastrointestinal_hemorrhage1.60245924
56MP0003045_fibrosis1.59944526
57MP0000467_abnormal_esophagus_morphology1.58262539
58* MP0003111_abnormal_nucleus_morphology1.57448521
59MP0002177_abnormal_outer_ear1.57073105
60MP0002006_tumorigenesis1.56372801
61MP0008438_abnormal_cutaneous_collagen1.55257101
62MP0002398_abnormal_bone_marrow1.53107774
63MP0005171_absent_coat_pigmentation1.50713836
64MP0004947_skin_inflammation1.49704026
65MP0000716_abnormal_immune_system1.44559887
66MP0001299_abnormal_eye_distance/1.44302083
67MP0003755_abnormal_palate_morphology1.43155480
68MP0002233_abnormal_nose_morphology1.41464554
69MP0001845_abnormal_inflammatory_respons1.41382475
70MP0008260_abnormal_autophagy1.39857078
71MP0005464_abnormal_platelet_physiology1.39756473
72MP0009053_abnormal_anal_canal1.39255391
73MP0003718_maternal_effect1.38254871
74MP0000432_abnormal_head_morphology1.37164464
75MP0003172_abnormal_lysosome_physiology1.34802032
76MP0006054_spinal_hemorrhage1.34536576
77MP0001851_eye_inflammation1.34078910
78MP0005058_abnormal_lysosome_morphology1.33943580
79MP0000689_abnormal_spleen_morphology1.33913240
80MP0002396_abnormal_hematopoietic_system1.33800161
81MP0001958_emphysema1.33374559
82MP0002102_abnormal_ear_morphology1.33076270
83MP0009333_abnormal_splenocyte_physiolog1.32885789
84MP0004084_abnormal_cardiac_muscle1.32395012
85MP0002722_abnormal_immune_system1.31019781
86MP0003935_abnormal_craniofacial_develop1.30472864
87MP0008877_abnormal_DNA_methylation1.30099658
88MP0003119_abnormal_digestive_system1.30004099
89MP0003656_abnormal_erythrocyte_physiolo1.28107938
90MP0009764_decreased_sensitivity_to1.28103978
91MP0000778_abnormal_nervous_system1.28094830
92MP0001853_heart_inflammation1.27930270
93MP0005423_abnormal_somatic_nervous1.27757169
94MP0005164_abnormal_response_to1.27105689
95MP0010155_abnormal_intestine_physiology1.27053098
96MP0004036_abnormal_muscle_relaxation1.25978608
97MP0002116_abnormal_craniofacial_bone1.25139359
98MP0000703_abnormal_thymus_morphology1.24759538
99MP0009672_abnormal_birth_weight1.24597624
100MP0001293_anophthalmia1.23963582
101MP0001286_abnormal_eye_development1.23427998
102MP0002111_abnormal_tail_morphology1.20701823
103MP0000762_abnormal_tongue_morphology1.20587746
104MP0005275_abnormal_skin_tensile1.17742808
105MP0002085_abnormal_embryonic_tissue1.15449041
106MP0002429_abnormal_blood_cell1.13590742
107MP0003077_abnormal_cell_cycle1.12598845
108MP0005174_abnormal_tail_pigmentation1.11698832
109MP0002998_abnormal_bone_remodeling1.11159103
110MP0001873_stomach_inflammation1.10752199
111MP0003942_abnormal_urinary_system1.09890316
112MP0008469_abnormal_protein_level1.09886605
113MP0005075_abnormal_melanosome_morpholog1.09285167
114MP0005310_abnormal_salivary_gland1.09137729
115MP0002009_preneoplasia1.07428732
116MP0000631_abnormal_neuroendocrine_gland1.06543214
117MP0004142_abnormal_muscle_tone1.04752366
118MP0003861_abnormal_nervous_system1.04104110
119MP0001340_abnormal_eyelid_morphology1.04088694
120MP0005380_embryogenesis_phenotype1.03276055
121MP0001672_abnormal_embryogenesis/_devel1.03276055
122MP0002332_abnormal_exercise_endurance1.03188555
123MP0002638_abnormal_pupillary_reflex1.03161137
124MP0003075_altered_response_to1.01017404
125MP0003448_altered_tumor_morphology1.00251108
126MP0004130_abnormal_muscle_cell0.99574987
127MP0004808_abnormal_hematopoietic_stem0.99552283
128MP0004883_abnormal_blood_vessel0.99389085
129MP0003091_abnormal_cell_migration0.98346985
130MP0003866_abnormal_defecation0.97628950
131MP0008789_abnormal_olfactory_epithelium0.97218083
132MP0002932_abnormal_joint_morphology0.96173338
133MP0005165_increased_susceptibility_to0.95621484
134MP0002060_abnormal_skin_morphology0.94704284
135MP0009763_increased_sensitivity_to0.93710237
136MP0000013_abnormal_adipose_tissue0.92791748
137MP0005503_abnormal_tendon_morphology0.91979599
138MP0003646_muscle_fatigue0.91877738
139MP0002092_abnormal_eye_morphology0.91417555
140MP0000350_abnormal_cell_proliferation0.91088943
141MP0000613_abnormal_salivary_gland0.90319596
142MP0003950_abnormal_plasma_membrane0.89387604
143MP0001730_embryonic_growth_arrest0.86529710
144MP0002114_abnormal_axial_skeleton0.85850932
145MP0002138_abnormal_hepatobiliary_system0.85841835
146MP0003941_abnormal_skin_development0.85489381
147MP0001697_abnormal_embryo_size0.84983473
148MP0005330_cardiomyopathy0.84171480
149MP0000015_abnormal_ear_pigmentation0.83343855
150MP0002088_abnormal_embryonic_growth/wei0.83079334
151MP0004145_abnormal_muscle_electrophysio0.82521391
152MP0002938_white_spotting0.81851822
153MP0005390_skeleton_phenotype0.81790660
154MP0004484_altered_response_of0.81506672
155MP0003984_embryonic_growth_retardation0.81499756
156MP0000569_abnormal_digit_pigmentation0.81029442
157MP0003183_abnormal_peptide_metabolism0.80599229
158MP0001348_abnormal_lacrimal_gland0.80555811
159MP0003795_abnormal_bone_structure0.80517617
160MP0002752_abnormal_somatic_nervous0.80440133
161MP0002697_abnormal_eye_size0.80024702
162MP0000249_abnormal_blood_vessel0.79830526
163MP0005451_abnormal_body_composition0.79421351
164MP0003806_abnormal_nucleotide_metabolis0.78962506
165MP0003221_abnormal_cardiomyocyte_apopto0.77794187
166MP0001346_abnormal_lacrimal_gland0.77292488
167MP0008004_abnormal_stomach_pH0.74129752
168MP0003566_abnormal_cell_adhesion0.74090220
169MP0000920_abnormal_myelination0.73829600
170MP0005166_decreased_susceptibility_to0.73164450
171MP0002933_joint_inflammation0.72736208
172MP0000163_abnormal_cartilage_morphology0.72031193
173MP0002152_abnormal_brain_morphology0.71960859
174MP0002084_abnormal_developmental_patter0.71925621
175MP0008058_abnormal_DNA_repair0.71391167
176MP0009384_cardiac_valve_regurgitation0.70610428
177MP0000749_muscle_degeneration0.70573638
178MP0002876_abnormal_thyroid_physiology0.70229295
179MP0002269_muscular_atrophy0.69269608
180* MP0002081_perinatal_lethality0.69216580
181MP0009840_abnormal_foam_cell0.68846253
182MP0002080_prenatal_lethality0.67414471
183MP0003252_abnormal_bile_duct0.67376987
184MP0003279_aneurysm0.67295417
185MP0000566_synostosis0.67031416
186MP0009703_decreased_birth_body0.66562181
187MP0000733_abnormal_muscle_development0.65325445
188MP0000534_abnormal_ureter_morphology0.63396389
189MP0003115_abnormal_respiratory_system0.63145670
190MP0000858_altered_metastatic_potential0.62931635
191MP0005408_hypopigmentation0.61859451
192MP0002210_abnormal_sex_determination0.61317720
193MP0005508_abnormal_skeleton_morphology0.59194271
194MP0003123_paternal_imprinting0.58837349

Predicted human phenotypes

RankGene SetZ-score
1Concave nail (HP:0001598)5.77120499
2Obstructive sleep apnea (HP:0002870)5.67665372
3T lymphocytopenia (HP:0005403)4.41500753
4Alacrima (HP:0000522)4.36378077
5Myositis (HP:0100614)4.33328478
6Abnormality of T cell number (HP:0011839)4.22882365
7Abnormal sex determination (HP:0012244)4.20272636
8Sex reversal (HP:0012245)4.20272636
9Septo-optic dysplasia (HP:0100842)4.17979865
10Cerebral hypomyelination (HP:0006808)4.17911018
11Orchitis (HP:0100796)4.17065994
12Elevated erythrocyte sedimentation rate (HP:0003565)4.09852031
13Retrobulbar optic neuritis (HP:0100654)4.03284222
14Optic neuritis (HP:0100653)4.03284222
15Stomatitis (HP:0010280)3.90506813
16Breast hypoplasia (HP:0003187)3.86911767
17Macrocytic anemia (HP:0001972)3.76657311
18Gastrointestinal infarctions (HP:0005244)3.74071719
19Decreased lacrimation (HP:0000633)3.71205851
20Hyperglycinemia (HP:0002154)3.63608103
21Reticulocytopenia (HP:0001896)3.57146663
22Eczematoid dermatitis (HP:0000976)3.47152553
23Recurrent abscess formation (HP:0002722)3.44902676
24Recurrent bacterial skin infections (HP:0005406)3.43579833
25Autoimmune hemolytic anemia (HP:0001890)3.36591115
26Abnormal delayed hypersensitivity skin test (HP:0002963)3.33880950
27Supernumerary spleens (HP:0009799)3.32350015
28Recurrent cutaneous fungal infections (HP:0011370)3.29935190
29Chronic mucocutaneous candidiasis (HP:0002728)3.29935190
30Sleep apnea (HP:0010535)3.28164238
31Generalized hypotonia (HP:0001290)3.14023212
32Chest pain (HP:0100749)3.12532878
33Abnormality of the septum pellucidum (HP:0007375)3.12335018
34Recurrent fungal infections (HP:0002841)3.11219997
35Keratoconjunctivitis sicca (HP:0001097)3.11129921
36Absent septum pellucidum (HP:0001331)3.09448609
37Abnormality of T cells (HP:0002843)3.09378107
38Asplenia (HP:0001746)3.05455744
39Arterial thrombosis (HP:0004420)2.99489258
40Abnormality of the axillary hair (HP:0100134)2.99143152
41Abnormality of secondary sexual hair (HP:0009888)2.99143152
42Nemaline bodies (HP:0003798)2.98206501
43Aplasia/Hypoplasia of the sacrum (HP:0008517)2.96658341
44Aplasia/Hypoplasia of the patella (HP:0006498)2.96329066
45Chin dimple (HP:0010751)2.95391521
46Pulmonary infiltrates (HP:0002113)2.94924489
47Keratoconjunctivitis (HP:0001096)2.94343785
48Abnormality of macrophages (HP:0004311)2.94218399
49Rhabdomyosarcoma (HP:0002859)2.93809882
50Horseshoe kidney (HP:0000085)2.93034817
51Optic nerve hypoplasia (HP:0000609)2.89473852
52Aplasia/Hypoplasia of the spleen (HP:0010451)2.89031120
53Abnormality of pyrimidine metabolism (HP:0004353)2.88973863
54Recurrent skin infections (HP:0001581)2.84506563
55Hypoplasia of the radius (HP:0002984)2.82856955
56Hypoplastic pelvis (HP:0008839)2.80339612
57Maternal diabetes (HP:0009800)2.77805804
58Pallor (HP:0000980)2.76658835
59Congenital malformation of the right heart (HP:0011723)2.76244402
60Double outlet right ventricle (HP:0001719)2.76244402
61Muscle fiber inclusion bodies (HP:0100299)2.73713970
62Exercise-induced myalgia (HP:0003738)2.72084597
63Hemoptysis (HP:0002105)2.70875816
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.70341922
65Spondylolisthesis (HP:0003302)2.66888550
66Fatigue (HP:0012378)2.66873597
67Vasculitis (HP:0002633)2.65671548
68Abnormality of T cell physiology (HP:0011840)2.64027863
69Absent forearm bone (HP:0003953)2.64025333
70Aplasia involving forearm bones (HP:0009822)2.64025333
71Facial diplegia (HP:0001349)2.61308504
72Absent radius (HP:0003974)2.60241041
73Trismus (HP:0000211)2.59067095
74Recurrent viral infections (HP:0004429)2.58754526
75Aplasia/hypoplasia of the uterus (HP:0008684)2.56888033
76Meningitis (HP:0001287)2.52800450
77Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.52401791
78Peritonitis (HP:0002586)2.51161658
79Granulocytopenia (HP:0001913)2.49904156
80Patellar aplasia (HP:0006443)2.49463098
81Gingival bleeding (HP:0000225)2.48829993
82Abnormality of glycolipid metabolism (HP:0010969)2.48245278
83Abnormality of liposaccharide metabolism (HP:0010968)2.48245278
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.48245278
85Gingivitis (HP:0000230)2.46315279
86Abnormality of eosinophils (HP:0001879)2.44584364
87Leukocytosis (HP:0001974)2.44215638
88Mediastinal lymphadenopathy (HP:0100721)2.37328331
89Eosinophilia (HP:0001880)2.36581733
90Osteolytic defects of the hand bones (HP:0009699)2.36433467
91Osteolytic defects of the phalanges of the hand (HP:0009771)2.36433467
92Anomalous pulmonary venous return (HP:0010772)2.35259494
93Cleft eyelid (HP:0000625)2.34383554
94Supernumerary bones of the axial skeleton (HP:0009144)2.33932329
95Aplasia/Hypoplasia of the breasts (HP:0010311)2.32269040
96Encephalitis (HP:0002383)2.30318046
97Hyporeflexia of lower limbs (HP:0002600)2.26725698
98Testicular atrophy (HP:0000029)2.25107615
99Recurrent gram-negative bacterial infections (HP:0005420)2.24084964
100Chronic diarrhea (HP:0002028)2.23555257
101Esophageal atresia (HP:0002032)2.20660467
102Gangrene (HP:0100758)2.20370705
103Broad-based gait (HP:0002136)2.19155775
104Anorexia (HP:0002039)2.18841469
105Dysostosis multiplex (HP:0000943)2.18550034
106Rhabdomyolysis (HP:0003201)2.18512741
107Coronal craniosynostosis (HP:0004440)2.17579029
108Impulsivity (HP:0100710)2.17391140
109Abnormality of abdominal situs (HP:0011620)2.17348661
110Abdominal situs inversus (HP:0003363)2.17348661
111Recurrent bronchitis (HP:0002837)2.15973395
112Acute hepatic failure (HP:0006554)2.15649209
113Pustule (HP:0200039)2.15550380
114Spastic paraparesis (HP:0002313)2.14764724
115Urticaria (HP:0001025)2.14228526
116Polyneuropathy (HP:0001271)2.13728622
117Abnormality of the fetal cardiovascular system (HP:0010948)2.12070701
118Abnormal umbilical cord blood vessels (HP:0011403)2.12070701
119Single umbilical artery (HP:0001195)2.12070701
120Abnormality of the pulmonary veins (HP:0011718)2.11893757
121Neoplasm of striated muscle (HP:0009728)2.11029629
122Thyroiditis (HP:0100646)2.09707467
123Abnormality of monocarboxylic acid metabolism (HP:0010996)2.09496749
124IgG deficiency (HP:0004315)2.09001958
125Sparse lateral eyebrow (HP:0005338)2.08761341
126Abnormality of skeletal muscle fiber size (HP:0012084)2.07239745
127Severe combined immunodeficiency (HP:0004430)2.06913612
128Abnormality of the pericardium (HP:0001697)2.06363770
129Abnormality of the pleura (HP:0002103)2.06070408
130Birth length less than 3rd percentile (HP:0003561)2.05479987
131Ridged nail (HP:0001807)2.05375809
132Delayed CNS myelination (HP:0002188)2.05210302
133Partial duplication of the phalanx of hand (HP:0009999)2.04482571
134Peripheral hypomyelination (HP:0007182)2.03574575
135Hyperglycinuria (HP:0003108)2.03036787
136Joint swelling (HP:0001386)2.01506900
137Chronic obstructive pulmonary disease (HP:0006510)2.01501811
138Obstructive lung disease (HP:0006536)2.01501811
139Interstitial pulmonary disease (HP:0006530)2.01499390
140Optic disc pallor (HP:0000543)2.01252062
141Attenuation of retinal blood vessels (HP:0007843)2.01177321
142Megaloblastic anemia (HP:0001889)2.01138275
143Vertigo (HP:0002321)2.00971203
144Aortic dissection (HP:0002647)1.99814066
145Fibular aplasia (HP:0002990)1.99192087
146Epistaxis (HP:0000421)1.98963807
147Abnormality of the endocardium (HP:0004306)1.98634484
148Decreased muscle mass (HP:0003199)1.98284700
149Deep palmar crease (HP:0006191)1.98008526
150CNS hypomyelination (HP:0003429)1.97894756
151Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.96633045
152Asymmetric septal hypertrophy (HP:0001670)1.96424271
153Myoglobinuria (HP:0002913)1.95850370
154Restlessness (HP:0000711)1.94948080
155Absent speech (HP:0001344)1.94435631
156Type 1 muscle fiber predominance (HP:0003803)1.94022093
157Bronchomalacia (HP:0002780)1.93932906
158Pulmonary embolism (HP:0002204)1.93792130
159Amyloidosis (HP:0011034)1.93789638
160Breast aplasia (HP:0100783)1.92987480
161Triphalangeal thumb (HP:0001199)1.92688980
162Abnormality of cells of the erythroid lineage (HP:0012130)1.92426439
163Fused cervical vertebrae (HP:0002949)1.91931973
164Morphological abnormality of the inner ear (HP:0011390)1.91727142
165Aortic aneurysm (HP:0004942)1.90418648
166Aplasia/hypoplasia of the humerus (HP:0006507)1.89834924
167Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89383432
168Dilatation of the ascending aorta (HP:0005111)1.89263335
169High anterior hairline (HP:0009890)1.87464198
170Atresia of the external auditory canal (HP:0000413)1.87376197
171Large earlobe (HP:0009748)1.87101496
172Split foot (HP:0001839)1.86962295
173Glomerulopathy (HP:0100820)1.85857775
174EMG: myopathic abnormalities (HP:0003458)1.85674971
175Papilledema (HP:0001085)1.85337236
176Abnormality of the left ventricular outflow tract (HP:0011103)1.84969119
177Subaortic stenosis (HP:0001682)1.84969119
178Increased CSF protein (HP:0002922)1.84902986
179Abnormality of glycine metabolism (HP:0010895)1.84581691
180Abnormality of serine family amino acid metabolism (HP:0010894)1.84581691
181Increased IgE level (HP:0003212)1.84561595
182Supernumerary ribs (HP:0005815)1.84060515
183Osteomyelitis (HP:0002754)1.83788999
184Episodic fever (HP:0001954)1.82949812
185Glossoptosis (HP:0000162)1.81657159
186Basal ganglia calcification (HP:0002135)1.81057383
187Hepatocellular necrosis (HP:0001404)1.79775057
188Plagiocephaly (HP:0001357)1.79251633
189Seborrheic dermatitis (HP:0001051)1.78935948
190Autoimmune thrombocytopenia (HP:0001973)1.78919629
191Broad hallux (HP:0010055)1.78721275
192Intellectual disability, moderate (HP:0002342)1.78647297
193Periodontitis (HP:0000704)1.78391335
194Delayed myelination (HP:0012448)1.77695326
195Hypergammaglobulinemia (HP:0010702)1.77612691
196Secondary amenorrhea (HP:0000869)1.77214452
197Abnormal lung lobation (HP:0002101)1.76241686
198Hypoplasia of the thymus (HP:0000778)1.75940183
199Agammaglobulinemia (HP:0004432)1.72778967
200Areflexia of lower limbs (HP:0002522)1.72310617

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK18.20830739
2CASK7.57071370
3TAOK34.67205029
4PHKG13.90990423
5PHKG23.90990423
6MKNK23.84462340
7TXK3.19198335
8MAP3K142.77081929
9NLK2.35449918
10JAK12.30058755
11PIK3CG2.27857139
12MKNK12.20477444
13MAP4K12.13634547
14TYK22.07820397
15TRPM72.01974413
16ERN11.92780213
17BLK1.91337441
18JAK31.89916149
19NME21.85615435
20RIPK41.80800343
21GRK61.77736538
22CSK1.77488807
23MAP3K131.74702758
24SRPK11.74037786
25EPHB11.71126217
26KIT1.67590130
27MAP3K31.62869736
28BMPR21.62635868
29BUB11.57556244
30FRK1.54181480
31TBK11.50798930
32TESK21.48017556
33IKBKE1.47258880
34SCYL21.46572650
35EIF2AK31.43985907
36DAPK31.43125624
37TEC1.40743240
38SIK31.38613547
39CDC71.38152762
40PKN11.34419364
41OBSCN1.34408537
42STK381.32304796
43TGFBR21.32257954
44TTN1.30468131
45BRD41.29031351
46PRPF4B1.28343026
47PNCK1.27791249
48ITK1.27014626
49HCK1.26405531
50EPHA31.26168578
51PBK1.25110013
52SYK1.23184721
53BTK1.22625922
54EIF2AK11.18355780
55JAK21.16995410
56MAP3K21.15067819
57CDK71.14027280
58LCK1.13264994
59ZAP701.11440661
60CSNK1G11.08366542
61CDK121.06114147
62NEK61.04383912
63DYRK21.03557894
64PAK11.00948260
65CLK11.00869983
66ACVR1B1.00525164
67IKBKB0.98819308
68FGFR30.97614034
69PAK20.97601472
70ERBB30.97228923
71DYRK1A0.95331415
72MAPKAPK30.93913648
73CDK60.93780632
74BMPR1B0.93277361
75MAP3K100.93270284
76TNK20.92993708
77IRAK20.91220758
78CDK40.89277393
79ILK0.86166428
80CSF1R0.85568684
81IRAK10.84535063
82MAP3K110.83379229
83LYN0.81447133
84MAP2K20.80166172
85MAP3K60.77123721
86MAPK70.74968475
87WEE10.73332888
88DDR20.73193293
89AKT30.69815089
90YES10.69251543
91NEK20.69130029
92AURKA0.68843278
93STK390.68390437
94IRAK40.68263744
95MARK30.68081827
96MAPK120.67685667
97MAPK110.67168477
98GRK10.66916604
99FES0.65657776
100MST40.64779453
101DYRK30.62310773
102ICK0.61151125
103MAP3K50.61059002
104GSK3A0.59690561
105UHMK10.58509345
106CDK80.57441726
107HIPK20.55092550
108MAP3K70.54800572
109RAF10.54723337
110CDK190.54650098
111PDGFRA0.54597237
112MAPKAPK20.54581914
113CSNK1E0.54556843
114MUSK0.54518100
115LATS10.54038802
116WNK10.53706278
117MYLK0.53145966
118MELK0.52829204
119GRK70.52747259
120PRKCQ0.50981999
121RPS6KA50.50826949
122TAOK10.49213720
123KSR20.48680401
124MAP3K80.47363821
125VRK10.47166553
126PINK10.45539745
127PDK10.45425750
128CAMKK20.45378714
129PTK2B0.44945259
130BRAF0.44551471
131SGK4940.44283317
132SGK2230.44283317
133ABL10.43502709
134MAPK150.43438200
135PDGFRB0.42546621
136SGK30.42132643
137BCKDK0.41584084
138EPHB20.40997425
139MOS0.40855533
140PRKCI0.40224739
141RPS6KA40.39850815
142NEK90.38979424
143ROCK20.38701878
144CSNK2A20.38547033
145IGF1R0.38142186
146PLK10.37893806
147EIF2AK20.37683233
148STK100.33801413
149MAP2K60.33787239
150FER0.33461567
151* CDK20.33403677
152ALK0.32789163
153LATS20.32706930
154TYRO30.32195310
155OXSR10.31610981
156AURKB0.31610490
157MAP3K10.29390795
158NME10.29176846
159STK110.27828955
160PRKG10.27783556
161CSNK2A10.27707408
162PRKAA20.27605572
163CSNK1D0.27406259
164TAOK20.27044818
165STK160.26436379
166CHEK20.26105433
167MAP2K30.24161793
168PRKD10.23921370
169PRKD20.23197444
170STK40.22088439
171ERBB20.21824882
172SGK20.20843140
173MAPK100.19716181
174CSNK1A10.18133033
175CAMK2B0.18025498
176MET0.17360478
177ERBB40.17246150
178IRAK30.17088633

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.58888555
2RNA polymerase_Homo sapiens_hsa030204.10356832
3DNA replication_Homo sapiens_hsa030303.93725989
4Spliceosome_Homo sapiens_hsa030403.84549571
5Proteasome_Homo sapiens_hsa030503.14573074
6One carbon pool by folate_Homo sapiens_hsa006703.10609081
7Sulfur relay system_Homo sapiens_hsa041223.07599787
8Mismatch repair_Homo sapiens_hsa034303.02500120
9Primary immunodeficiency_Homo sapiens_hsa053402.55183567
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.52293303
11Homologous recombination_Homo sapiens_hsa034402.47674613
12RNA transport_Homo sapiens_hsa030132.44000527
13Osteoclast differentiation_Homo sapiens_hsa043802.40055554
14Protein export_Homo sapiens_hsa030602.32385074
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.31854736
16Leishmaniasis_Homo sapiens_hsa051402.28016240
17Base excision repair_Homo sapiens_hsa034102.20817795
18Measles_Homo sapiens_hsa051622.19557308
19Graft-versus-host disease_Homo sapiens_hsa053322.16707311
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16600714
21Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.12528111
22Pyrimidine metabolism_Homo sapiens_hsa002402.12249023
23Autoimmune thyroid disease_Homo sapiens_hsa053202.09210371
24Allograft rejection_Homo sapiens_hsa053302.07331569
25T cell receptor signaling pathway_Homo sapiens_hsa046602.06961833
26Hematopoietic cell lineage_Homo sapiens_hsa046402.02092329
27Jak-STAT signaling pathway_Homo sapiens_hsa046302.01014917
28Folate biosynthesis_Homo sapiens_hsa007901.97130493
29NF-kappa B signaling pathway_Homo sapiens_hsa040641.93206040
30Nucleotide excision repair_Homo sapiens_hsa034201.92188577
31Fanconi anemia pathway_Homo sapiens_hsa034601.86365092
32Basal cell carcinoma_Homo sapiens_hsa052171.84544752
33Malaria_Homo sapiens_hsa051441.83234270
34mRNA surveillance pathway_Homo sapiens_hsa030151.82198857
35B cell receptor signaling pathway_Homo sapiens_hsa046621.82102941
36Antigen processing and presentation_Homo sapiens_hsa046121.80846711
37Staphylococcus aureus infection_Homo sapiens_hsa051501.78175163
38Type I diabetes mellitus_Homo sapiens_hsa049401.72805816
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.67688749
40Tuberculosis_Homo sapiens_hsa051521.62307868
41Toll-like receptor signaling pathway_Homo sapiens_hsa046201.60186872
42Legionellosis_Homo sapiens_hsa051341.59665210
43Sphingolipid metabolism_Homo sapiens_hsa006001.55512600
44RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.54449361
45Toxoplasmosis_Homo sapiens_hsa051451.48881325
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.46088791
47TNF signaling pathway_Homo sapiens_hsa046681.43871927
48Basal transcription factors_Homo sapiens_hsa030221.37382639
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34880911
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.32940248
51Viral myocarditis_Homo sapiens_hsa054161.32328665
52Influenza A_Homo sapiens_hsa051641.31327011
53Platelet activation_Homo sapiens_hsa046111.30920706
54Circadian rhythm_Homo sapiens_hsa047101.28206533
55Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.25798414
56Hedgehog signaling pathway_Homo sapiens_hsa043401.25000345
57Non-small cell lung cancer_Homo sapiens_hsa052231.22895817
58Dorso-ventral axis formation_Homo sapiens_hsa043201.20632887
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.19923446
60Intestinal immune network for IgA production_Homo sapiens_hsa046721.19784905
61Chemokine signaling pathway_Homo sapiens_hsa040621.18948751
62Lysosome_Homo sapiens_hsa041421.18107961
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17459368
64Axon guidance_Homo sapiens_hsa043601.17426453
65Asthma_Homo sapiens_hsa053101.15855301
66Hepatitis B_Homo sapiens_hsa051611.15402347
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.14849836
68Cell cycle_Homo sapiens_hsa041101.14095321
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10418168
70MicroRNAs in cancer_Homo sapiens_hsa052061.09535920
71Bladder cancer_Homo sapiens_hsa052191.09066178
72Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06953505
73Leukocyte transendothelial migration_Homo sapiens_hsa046701.06682243
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.04245469
75Thyroid cancer_Homo sapiens_hsa052161.01001339
76Pancreatic cancer_Homo sapiens_hsa052120.98997099
77Purine metabolism_Homo sapiens_hsa002300.96972870
78Systemic lupus erythematosus_Homo sapiens_hsa053220.96470924
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95618671
80Pertussis_Homo sapiens_hsa051330.95192055
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94682531
82Notch signaling pathway_Homo sapiens_hsa043300.94496198
83Prostate cancer_Homo sapiens_hsa052150.93792217
84Hepatitis C_Homo sapiens_hsa051600.93550431
85Melanogenesis_Homo sapiens_hsa049160.92513008
86Wnt signaling pathway_Homo sapiens_hsa043100.91134768
87Rheumatoid arthritis_Homo sapiens_hsa053230.89830020
88Apoptosis_Homo sapiens_hsa042100.88603004
89RNA degradation_Homo sapiens_hsa030180.88477011
90Arachidonic acid metabolism_Homo sapiens_hsa005900.87718114
91Phagosome_Homo sapiens_hsa041450.87507135
92Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87247576
93Nitrogen metabolism_Homo sapiens_hsa009100.86373610
94Insulin resistance_Homo sapiens_hsa049310.82537897
95Shigellosis_Homo sapiens_hsa051310.82160550
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.80819779
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78878437
98Inositol phosphate metabolism_Homo sapiens_hsa005620.78482157
99Amoebiasis_Homo sapiens_hsa051460.78364602
100FoxO signaling pathway_Homo sapiens_hsa040680.77838258
101Hippo signaling pathway_Homo sapiens_hsa043900.76001473
102Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75318993
103Phototransduction_Homo sapiens_hsa047440.74818796
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74598618
105Other glycan degradation_Homo sapiens_hsa005110.73989622
106Prolactin signaling pathway_Homo sapiens_hsa049170.73764784
107Small cell lung cancer_Homo sapiens_hsa052220.72832156
108Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71538205
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.70559766
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.68964126
111Endocytosis_Homo sapiens_hsa041440.68401672
112Focal adhesion_Homo sapiens_hsa045100.67768371
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67063831
114Regulation of autophagy_Homo sapiens_hsa041400.66367571
115Renal cell carcinoma_Homo sapiens_hsa052110.66054991
116Viral carcinogenesis_Homo sapiens_hsa052030.64098072
117Arginine biosynthesis_Homo sapiens_hsa002200.63359839
118Selenocompound metabolism_Homo sapiens_hsa004500.62453405
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61702101
120African trypanosomiasis_Homo sapiens_hsa051430.61689669
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60979408
122Tight junction_Homo sapiens_hsa045300.58717577
123mTOR signaling pathway_Homo sapiens_hsa041500.58542781
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.57592507
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.57344600
126Neurotrophin signaling pathway_Homo sapiens_hsa047220.56300299
127Vitamin B6 metabolism_Homo sapiens_hsa007500.55414134
128Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55373465
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54931121
130Epstein-Barr virus infection_Homo sapiens_hsa051690.54812958
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53819534
132Salmonella infection_Homo sapiens_hsa051320.52176323
133VEGF signaling pathway_Homo sapiens_hsa043700.51350691
134Huntingtons disease_Homo sapiens_hsa050160.51287979
135Melanoma_Homo sapiens_hsa052180.47744500
136Long-term depression_Homo sapiens_hsa047300.47537014
137Arginine and proline metabolism_Homo sapiens_hsa003300.47286319
138Vascular smooth muscle contraction_Homo sapiens_hsa042700.42734245
139Dilated cardiomyopathy_Homo sapiens_hsa054140.42452100
140Linoleic acid metabolism_Homo sapiens_hsa005910.42326037
141Proteoglycans in cancer_Homo sapiens_hsa052050.42232851
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.41393280
143Oxidative phosphorylation_Homo sapiens_hsa001900.39625892
144HTLV-I infection_Homo sapiens_hsa051660.38423527
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38285943
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.37936327
147Complement and coagulation cascades_Homo sapiens_hsa046100.36999255
148Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35742331
149Alcoholism_Homo sapiens_hsa050340.35571126
150Parkinsons disease_Homo sapiens_hsa050120.35435818
151Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35121087
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34894916
153Glutathione metabolism_Homo sapiens_hsa004800.34475754
154ABC transporters_Homo sapiens_hsa020100.33794992
155GnRH signaling pathway_Homo sapiens_hsa049120.33196144
156Retinol metabolism_Homo sapiens_hsa008300.31911241
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.31084070
158Ether lipid metabolism_Homo sapiens_hsa005650.30930841
159Vitamin digestion and absorption_Homo sapiens_hsa049770.30415657
160Pathways in cancer_Homo sapiens_hsa052000.28017788
161MAPK signaling pathway_Homo sapiens_hsa040100.27573992
162Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.26121724
163ErbB signaling pathway_Homo sapiens_hsa040120.23793134
164Acute myeloid leukemia_Homo sapiens_hsa052210.21240309
165Gap junction_Homo sapiens_hsa045400.19425972
166Chronic myeloid leukemia_Homo sapiens_hsa052200.19101487
167alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18812532
168Cardiac muscle contraction_Homo sapiens_hsa042600.17847009
169Cyanoamino acid metabolism_Homo sapiens_hsa004600.17698975
170Insulin signaling pathway_Homo sapiens_hsa049100.17551436
171Herpes simplex infection_Homo sapiens_hsa051680.16668420
172Pentose phosphate pathway_Homo sapiens_hsa000300.16462491
173Metabolic pathways_Homo sapiens_hsa011000.16192586
174Glycosaminoglycan degradation_Homo sapiens_hsa005310.15449389
175Oocyte meiosis_Homo sapiens_hsa041140.14086511
176Sphingolipid signaling pathway_Homo sapiens_hsa040710.13513900
177Glucagon signaling pathway_Homo sapiens_hsa049220.13461500
178Drug metabolism - other enzymes_Homo sapiens_hsa009830.13355257
179Glioma_Homo sapiens_hsa052140.13330670
180Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.12727486
181Non-homologous end-joining_Homo sapiens_hsa034500.12612288
182TGF-beta signaling pathway_Homo sapiens_hsa043500.12130992
183Maturity onset diabetes of the young_Homo sapiens_hsa049500.11277031
184Lysine degradation_Homo sapiens_hsa003100.08980056
185Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.08751138

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