TOP2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic sister chromatid cohesion (GO:0007064)4.51655497
2regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.34829792
3cytoplasmic mRNA processing body assembly (GO:0033962)3.83541893
4establishment of nucleus localization (GO:0040023)3.66861349
5regulation of RNA export from nucleus (GO:0046831)3.55991156
6neuron projection extension involved in neuron projection guidance (GO:1902284)3.40294224
7axon extension involved in axon guidance (GO:0048846)3.40294224
8layer formation in cerebral cortex (GO:0021819)3.37322694
9glial cell proliferation (GO:0014009)3.33319576
10* DNA topological change (GO:0006265)3.31212328
11dosage compensation (GO:0007549)3.23260920
12regulation of centriole replication (GO:0046599)3.22962080
13nuclear pore complex assembly (GO:0051292)3.19350214
14negative regulation of neurotransmitter secretion (GO:0046929)3.19102403
15glucocorticoid receptor signaling pathway (GO:0042921)3.18346769
16insulin-like growth factor receptor signaling pathway (GO:0048009)3.18136431
17alternative mRNA splicing, via spliceosome (GO:0000380)3.17189049
18* DNA unwinding involved in DNA replication (GO:0006268)3.16342163
19nerve growth factor signaling pathway (GO:0038180)3.12814687
20* sister chromatid segregation (GO:0000819)3.12560993
21somatic cell DNA recombination (GO:0016444)3.12372171
22somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.12372171
23negative regulation of fibroblast apoptotic process (GO:2000270)3.12250430
24phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.11769608
25germ cell migration (GO:0008354)3.10232173
26negative regulation of RNA splicing (GO:0033119)3.09628411
27nucleosome disassembly (GO:0006337)3.08295481
28protein-DNA complex disassembly (GO:0032986)3.08295481
29presynaptic membrane assembly (GO:0097105)3.06681714
30negative regulation of histone methylation (GO:0031061)3.06142871
31mRNA splice site selection (GO:0006376)3.05334223
32negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.01540788
33peptidyl-lysine dimethylation (GO:0018027)2.94959368
34histone H3-K9 methylation (GO:0051567)2.92583006
35* DNA duplex unwinding (GO:0032508)2.91944820
36definitive hemopoiesis (GO:0060216)2.90671020
37hippo signaling (GO:0035329)2.88736587
38regulation of DNA endoreduplication (GO:0032875)2.88656550
39regulation of nucleobase-containing compound transport (GO:0032239)2.86331744
40pyrimidine nucleobase catabolic process (GO:0006208)2.84433727
41protein localization to chromosome, centromeric region (GO:0071459)2.84381531
42gastrulation with mouth forming second (GO:0001702)2.84337131
43sister chromatid cohesion (GO:0007062)2.84327073
44regulation of histone methylation (GO:0031060)2.84211177
45non-recombinational repair (GO:0000726)2.83508574
46double-strand break repair via nonhomologous end joining (GO:0006303)2.83508574
47* DNA geometric change (GO:0032392)2.81863833
48ATP-dependent chromatin remodeling (GO:0043044)2.79878643
49microtubule anchoring (GO:0034453)2.79568447
50regulation of sister chromatid cohesion (GO:0007063)2.79087889
51pre-miRNA processing (GO:0031054)2.79033606
52protein localization to kinetochore (GO:0034501)2.78367433
53histone ubiquitination (GO:0016574)2.77244922
54somatic diversification of immune receptors (GO:0002200)2.76654723
55presynaptic membrane organization (GO:0097090)2.76330451
56histone H3-K36 demethylation (GO:0070544)2.76176698
57nucleus localization (GO:0051647)2.75985840
58corticosteroid receptor signaling pathway (GO:0031958)2.75849828
59mitotic sister chromatid segregation (GO:0000070)2.75643978
60histone H3-K9 demethylation (GO:0033169)2.75500599
61histone monoubiquitination (GO:0010390)2.75455509
62positive regulation of histone deacetylation (GO:0031065)2.74972635
63regulation of centrosome duplication (GO:0010824)2.73747429
64positive regulation of histone methylation (GO:0031062)2.73446989
65positive regulation of RNA splicing (GO:0033120)2.70998175
66central nervous system projection neuron axonogenesis (GO:0021952)2.68830292
67positive regulation of histone H3-K4 methylation (GO:0051571)2.68572927
68dorsal/ventral axis specification (GO:0009950)2.63722892
69mRNA stabilization (GO:0048255)2.61373166
70RNA stabilization (GO:0043489)2.61373166
71T cell differentiation in thymus (GO:0033077)2.58888989
72regulation of DNA damage checkpoint (GO:2000001)2.58868894
73nuclear pore organization (GO:0006999)2.58198016
74V(D)J recombination (GO:0033151)2.58152787
75kinetochore organization (GO:0051383)2.57254046
76negative regulation of axon extension involved in axon guidance (GO:0048843)2.56457472
77regulation of histone H3-K9 methylation (GO:0051570)2.55638348
78paraxial mesoderm development (GO:0048339)2.54851845
79membrane disassembly (GO:0030397)2.54687660
80nuclear envelope disassembly (GO:0051081)2.54687660
81translesion synthesis (GO:0019985)2.54506411
82negative regulation of axon guidance (GO:1902668)2.54329270
83mitotic nuclear envelope disassembly (GO:0007077)2.54241479
84histone H3-K9 modification (GO:0061647)2.53476436
85stress granule assembly (GO:0034063)2.51480402
86negative regulation of cell killing (GO:0031342)2.50423577
87negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50423577
88generation of neurons (GO:0048699)2.49623204
89positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49551036
90positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49551036
91positive regulation of mitotic sister chromatid separation (GO:1901970)2.49551036
92positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.48472908
93nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.48038916
94regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.47507794
95DNA ligation (GO:0006266)2.47135151
96nucleus organization (GO:0006997)2.46502251
97histone H4-K16 acetylation (GO:0043984)2.45344068
98negative regulation of mRNA processing (GO:0050686)2.44678835
99mRNA transport (GO:0051028)2.44605918
100labyrinthine layer development (GO:0060711)2.42272151
101* DNA conformation change (GO:0071103)2.42216023
102regulation of mRNA stability (GO:0043488)2.41950201
103regulation of centrosome cycle (GO:0046605)2.41750739
104NLS-bearing protein import into nucleus (GO:0006607)2.41611763
105regulation of establishment of cell polarity (GO:2000114)2.40686122
106regulation of DNA-templated transcription, initiation (GO:2000142)2.40620939
107clathrin coat assembly (GO:0048268)2.40416714
108DNA synthesis involved in DNA repair (GO:0000731)2.40335821
109regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.39381411
110planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38399007
111histone H2B ubiquitination (GO:0033523)2.38008118
112neuronal stem cell maintenance (GO:0097150)2.37881192
113negative regulation of thymocyte apoptotic process (GO:0070244)2.37246876
114regulation of chromatin silencing (GO:0031935)2.37222914
115monoubiquitinated protein deubiquitination (GO:0035520)2.36934468
116histone lysine demethylation (GO:0070076)2.35081624
117regulation of axon guidance (GO:1902667)2.34961549
118mitotic chromosome condensation (GO:0007076)2.34589783
119histone H3-K4 trimethylation (GO:0080182)2.34331998
120axon extension (GO:0048675)2.33812873
121regulation of axon extension involved in axon guidance (GO:0048841)2.33656108
122regulation of NFAT protein import into nucleus (GO:0051532)2.31055785
123peptidyl-lysine trimethylation (GO:0018023)2.30663067
124positive regulation of dendrite morphogenesis (GO:0050775)2.30639025
125embryonic foregut morphogenesis (GO:0048617)2.29078397
126dendrite morphogenesis (GO:0048813)2.28992634
127embryonic viscerocranium morphogenesis (GO:0048703)2.28851026
128negative regulation of oligodendrocyte differentiation (GO:0048715)2.28700219
129regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.27294874
130interkinetic nuclear migration (GO:0022027)2.25111030
131coronary vasculature morphogenesis (GO:0060977)2.22837158
132negative regulation of vascular permeability (GO:0043116)2.22583146
133histone mRNA catabolic process (GO:0071044)2.22524055
134positive regulation of dendritic spine morphogenesis (GO:0061003)2.21750727
135negative regulation of mRNA metabolic process (GO:1903312)2.21696767
136histone demethylation (GO:0016577)2.20747569
137axonal fasciculation (GO:0007413)2.20137108
138negative regulation of DNA repair (GO:0045738)2.19520440
139regulation of RNA stability (GO:0043487)2.18268694
140ectodermal placode formation (GO:0060788)2.17678353
141embryonic hemopoiesis (GO:0035162)2.17218788
142positive regulation of gamma-delta T cell activation (GO:0046645)2.16783415
143neural tube formation (GO:0001841)2.16725124
144embryonic camera-type eye morphogenesis (GO:0048596)2.15095494
145proximal/distal pattern formation (GO:0009954)2.13603137
146endothelial tube morphogenesis (GO:0061154)2.13226702
147morphogenesis of an endothelium (GO:0003159)2.13226702
148regulation of histone H3-K4 methylation (GO:0051569)2.12396005
149pore complex assembly (GO:0046931)2.12262869
150regulation of heart morphogenesis (GO:2000826)2.11444996
151heart morphogenesis (GO:0003007)2.10859640
152genitalia morphogenesis (GO:0035112)2.09429720
153head development (GO:0060322)2.08477088
154regulation of mRNA splicing, via spliceosome (GO:0048024)2.07712349
155histone lysine methylation (GO:0034968)2.07425126
156dendritic spine morphogenesis (GO:0060997)2.07078121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.83731741
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.36288009
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.96555972
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.67636614
5* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.58270224
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.57896727
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.48973737
8SALL1_21062744_ChIP-ChIP_HESCs_Human3.34225890
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.22032424
10MYC_22102868_ChIP-Seq_BL_Human2.95064011
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.51484633
12* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.35710050
13TP63_19390658_ChIP-ChIP_HaCaT_Human2.30527535
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.22232462
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.19758736
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.15899222
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.10882108
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08592223
19IGF1R_20145208_ChIP-Seq_DFB_Human2.05983205
20TAF15_26573619_Chip-Seq_HEK293_Human2.04443777
21HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.04202702
22EZH2_22144423_ChIP-Seq_EOC_Human2.01211212
23DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.99611610
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.96428288
25TCF7_22412390_ChIP-Seq_EML_Mouse1.91410158
26E2F4_17652178_ChIP-ChIP_JURKAT_Human1.85130191
27KDM2B_26808549_Chip-Seq_DND41_Human1.82813029
28KDM2B_26808549_Chip-Seq_JURKAT_Human1.75574609
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73743581
30FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.71236394
31AR_21909140_ChIP-Seq_LNCAP_Human1.66685519
32GATA1_22025678_ChIP-Seq_K562_Human1.66445664
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.65274791
34STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64482851
35PKCTHETA_26484144_Chip-Seq_BREAST_Human1.63101834
36RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.62443166
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61865072
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57982237
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57631468
40GBX2_23144817_ChIP-Seq_PC3_Human1.55279184
41KDM2B_26808549_Chip-Seq_SUP-B15_Human1.53674142
42FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53649663
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48749716
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.48655285
45* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.48085026
46ZFP57_27257070_Chip-Seq_ESCs_Mouse1.47156454
47TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.45826038
48CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.45659222
49CLOCK_20551151_ChIP-Seq_293T_Human1.45093856
50RUNX_20019798_ChIP-Seq_JUKART_Human1.44829827
51MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.43912210
52OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39537996
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39436568
54AR_21572438_ChIP-Seq_LNCaP_Human1.38296322
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.36435538
56* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35130156
57ISL1_27105846_Chip-Seq_CPCs_Mouse1.35027008
58STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.34038100
59* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.32805713
60* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31534142
61SOX9_26525672_Chip-Seq_HEART_Mouse1.28800376
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.28541710
63ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28287975
64VDR_21846776_ChIP-Seq_THP-1_Human1.27249728
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26566198
66CIITA_25753668_ChIP-Seq_RAJI_Human1.24967478
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.24654933
68PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.24303524
69SMAD_19615063_ChIP-ChIP_OVARY_Human1.22353297
70NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20747685
71TCF4_18268006_ChIP-ChIP_LS174T_Human1.20266594
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.20243246
73* UTX_26944678_Chip-Seq_JUKART_Human1.19411603
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18470013
75POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.18460761
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18460761
77SCL_19346495_ChIP-Seq_HPC-7_Human1.18273373
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18173633
79* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17176317
80* BRD4_25478319_ChIP-Seq_HGPS_Human1.16857795
81P300_19829295_ChIP-Seq_ESCs_Human1.16381910
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15341186
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.15188571
84SMAD4_21799915_ChIP-Seq_A2780_Human1.14758669
85EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14418207
86EWS_26573619_Chip-Seq_HEK293_Human1.14329442
87PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.13821909
88E2F1_21310950_ChIP-Seq_MCF-7_Human1.13443592
89PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13238874
90TRIM28_21343339_ChIP-Seq_HEK293_Human1.12732350
91SMAD3_21741376_ChIP-Seq_EPCs_Human1.11442931
92ZNF274_21170338_ChIP-Seq_K562_Hela1.10659401
93TP53_16413492_ChIP-PET_HCT116_Human1.10614014
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10477912
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10050366
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.09314276
97KDM2B_26808549_Chip-Seq_K562_Human1.08701285
98* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08256670
99STAT3_23295773_ChIP-Seq_U87_Human1.07830210
100* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06187100
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05781548
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05213977
103RNF2_27304074_Chip-Seq_NSC_Mouse1.05168850
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.05121676
105GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04371636
106ER_23166858_ChIP-Seq_MCF-7_Human1.03865301
107ARNT_22903824_ChIP-Seq_MCF-7_Human1.03740051
108NANOG_18555785_Chip-Seq_ESCs_Mouse1.03596089
109CTBP2_25329375_ChIP-Seq_LNCAP_Human1.03241752
110TBX3_20139965_ChIP-Seq_ESCs_Mouse1.03236039
111TBX3_20139965_ChIP-Seq_MESCs_Mouse1.03045324
112* MYB_26560356_Chip-Seq_TH2_Human1.02074758
113* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.02043522
114SOX2_16153702_ChIP-ChIP_HESCs_Human1.01013214
115CHD1_26751641_Chip-Seq_LNCaP_Human1.00990470
116POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.00783786
117MAF_26560356_Chip-Seq_TH1_Human1.00513123
118MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99821809
119GATA1_26923725_Chip-Seq_HPCs_Mouse0.99678380
120MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97670680
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97008705
122RNF2_27304074_Chip-Seq_ESCs_Mouse0.96980675
123CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96825035
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96816592
125LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96406945
126PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95482163
127TCF4_23295773_ChIP-Seq_U87_Human0.93950480
128CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93703237
129AHR_22903824_ChIP-Seq_MCF-7_Human0.93526271
130EZH2_27304074_Chip-Seq_ESCs_Mouse0.92830352
131KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.92820391
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.92820391
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.92820391
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.92262150
135E2F1_18555785_Chip-Seq_ESCs_Mouse0.91595411
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91405022
137EZH2_18974828_ChIP-Seq_MESCs_Mouse0.89170100
138RNF2_18974828_ChIP-Seq_MESCs_Mouse0.89170100
139ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88822818
140* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87409566
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87363261
142ESR1_20079471_ChIP-ChIP_T-47D_Human0.87333109
143POU5F1_16153702_ChIP-ChIP_HESCs_Human0.86613483
144SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86345574
145RING1B_27294783_Chip-Seq_ESCs_Mouse0.86233988
146* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85792235
147JARID2_20064375_ChIP-Seq_MESCs_Mouse0.85490884
148* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.85306096
149PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84954952
150AR_19668381_ChIP-Seq_PC3_Human0.84935838
151FUS_26573619_Chip-Seq_HEK293_Human0.83629096
152POU3F2_20337985_ChIP-ChIP_501MEL_Human0.82922347
153FOXO3_23340844_ChIP-Seq_DLD1_Human0.81689501
154DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81509877
155VDR_24763502_ChIP-Seq_THP-1_Human0.81043509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.70746606
2MP0000569_abnormal_digit_pigmentation3.60865134
3MP0000537_abnormal_urethra_morphology2.99446198
4MP0006054_spinal_hemorrhage2.66866849
5MP0003705_abnormal_hypodermis_morpholog2.66204677
6MP0003787_abnormal_imprinting2.63311609
7MP0010352_gastrointestinal_tract_polyps2.61577222
8MP0003121_genomic_imprinting2.57023974
9MP0010234_abnormal_vibrissa_follicle2.48829498
10MP0005076_abnormal_cell_differentiation2.46926840
11MP0005187_abnormal_penis_morphology2.05650742
12MP0002009_preneoplasia1.94260522
13MP0003111_abnormal_nucleus_morphology1.92206267
14MP0002166_altered_tumor_susceptibility1.91681790
15MP0003385_abnormal_body_wall1.85546760
16MP0004957_abnormal_blastocyst_morpholog1.84854456
17MP0003300_gastrointestinal_ulcer1.84339906
18MP0009053_abnormal_anal_canal1.83744981
19MP0000733_abnormal_muscle_development1.83406651
20MP0003122_maternal_imprinting1.80774672
21MP0004808_abnormal_hematopoietic_stem1.78262613
22MP0008877_abnormal_DNA_methylation1.75471069
23MP0003890_abnormal_embryonic-extraembry1.68438887
24MP0001879_abnormal_lymphatic_vessel1.66644233
25MP0000778_abnormal_nervous_system1.66525106
26MP0009672_abnormal_birth_weight1.63136668
27MP0009278_abnormal_bone_marrow1.59479678
28MP0003935_abnormal_craniofacial_develop1.59388331
29MP0000462_abnormal_digestive_system1.58217225
30MP0003123_paternal_imprinting1.55122626
31MP0003115_abnormal_respiratory_system1.54860034
32MP0004197_abnormal_fetal_growth/weight/1.52814108
33MP0000428_abnormal_craniofacial_morphol1.50856653
34MP0002396_abnormal_hematopoietic_system1.44619692
35MP0002282_abnormal_trachea_morphology1.42870088
36MP0003567_abnormal_fetal_cardiomyocyte1.41039567
37MP0005423_abnormal_somatic_nervous1.40603198
38MP0006292_abnormal_olfactory_placode1.38928951
39MP0010678_abnormal_skin_adnexa1.38362699
40MP0001849_ear_inflammation1.36073722
41MP0002084_abnormal_developmental_patter1.35115493
42MP0003693_abnormal_embryo_hatching1.33988208
43MP0001188_hyperpigmentation1.33908770
44MP0003942_abnormal_urinary_system1.33646601
45MP0005248_abnormal_Harderian_gland1.32830664
46MP0003880_abnormal_central_pattern1.30869221
47MP0003763_abnormal_thymus_physiology1.29981750
48MP0010030_abnormal_orbit_morphology1.27417967
49MP0008932_abnormal_embryonic_tissue1.27121191
50MP0001177_atelectasis1.26157648
51MP0008789_abnormal_olfactory_epithelium1.25917663
52MP0003937_abnormal_limbs/digits/tail_de1.25702641
53* MP0003861_abnormal_nervous_system1.25116798
54MP0008058_abnormal_DNA_repair1.25054230
55MP0008438_abnormal_cutaneous_collagen1.24355781
56MP0009250_abnormal_appendicular_skeleto1.23205692
57MP0002092_abnormal_eye_morphology1.23173573
58MP0000534_abnormal_ureter_morphology1.21954363
59MP0002932_abnormal_joint_morphology1.20130161
60MP0002006_tumorigenesis1.18785218
61MP0009780_abnormal_chondrocyte_physiolo1.18470197
62MP0005409_darkened_coat_color1.17367266
63MP0003119_abnormal_digestive_system1.16673979
64MP0000383_abnormal_hair_follicle1.16489204
65MP0000703_abnormal_thymus_morphology1.16312076
66MP0002925_abnormal_cardiovascular_devel1.16180118
67MP0004270_analgesia1.15386035
68MP0002697_abnormal_eye_size1.13792112
69MP0004859_abnormal_synaptic_plasticity1.13353987
70MP0001299_abnormal_eye_distance/1.13196401
71MP0003091_abnormal_cell_migration1.12428629
72MP0002085_abnormal_embryonic_tissue1.12219579
73MP0002877_abnormal_melanocyte_morpholog1.11692443
74MP0002751_abnormal_autonomic_nervous1.10900798
75MP0005275_abnormal_skin_tensile1.10883242
76MP0009703_decreased_birth_body1.10537971
77MP0003755_abnormal_palate_morphology1.09747744
78MP0003221_abnormal_cardiomyocyte_apopto1.08806275
79MP0005623_abnormal_meninges_morphology1.07662046
80MP0002080_prenatal_lethality1.07522556
81MP0001293_anophthalmia1.07235346
82MP0002086_abnormal_extraembryonic_tissu1.07155206
83MP0002088_abnormal_embryonic_growth/wei1.06308664
84MP0002116_abnormal_craniofacial_bone1.05409749
85MP0004185_abnormal_adipocyte_glucose1.04611337
86MP0009697_abnormal_copulation1.04297626
87MP0002233_abnormal_nose_morphology1.04242398
88MP0008961_abnormal_basal_metabolism1.04015842
89MP0003984_embryonic_growth_retardation1.02957801
90MP0002938_white_spotting1.02133854
91* MP0002152_abnormal_brain_morphology1.01821782
92MP0002234_abnormal_pharynx_morphology1.01695213
93MP0010094_abnormal_chromosome_stability1.01285939
94* MP0002081_perinatal_lethality1.00157714
95MP0000350_abnormal_cell_proliferation0.99527313
96* MP0000955_abnormal_spinal_cord0.99142618
97MP0001730_embryonic_growth_arrest0.98769700
98MP0005367_renal/urinary_system_phenotyp0.98288234
99MP0000516_abnormal_urinary_system0.98288234
100MP0005380_embryogenesis_phenotype0.95896335
101MP0001672_abnormal_embryogenesis/_devel0.95896335
102MP0002822_catalepsy0.94850075
103MP0000465_gastrointestinal_hemorrhage0.93787297
104MP0001915_intracranial_hemorrhage0.93524934
105MP0003303_peritoneal_inflammation0.92242635
106MP0000432_abnormal_head_morphology0.91420907
107MP0001286_abnormal_eye_development0.91385319
108MP0005503_abnormal_tendon_morphology0.90224807
109* MP0002184_abnormal_innervation0.90089547
110MP0010368_abnormal_lymphatic_system0.89930302
111MP0004134_abnormal_chest_morphology0.89377015
112MP0001784_abnormal_fluid_regulation0.88874808
113MP0008007_abnormal_cellular_replicative0.88788130
114* MP0004811_abnormal_neuron_physiology0.87048447
115MP0000566_synostosis0.86733857
116* MP0001697_abnormal_embryo_size0.85968050
117MP0002896_abnormal_bone_mineralization0.84858805
118MP0004233_abnormal_muscle_weight0.84704876
119MP0005499_abnormal_olfactory_system0.84307320
120MP0005394_taste/olfaction_phenotype0.84307320
121MP0006072_abnormal_retinal_apoptosis0.84189944
122MP0010307_abnormal_tumor_latency0.83625031
123MP0003315_abnormal_perineum_morphology0.83378369
124MP0003077_abnormal_cell_cycle0.80928410
125MP0000049_abnormal_middle_ear0.80877263
126MP0000631_abnormal_neuroendocrine_gland0.80783422
127MP0004084_abnormal_cardiac_muscle0.80000411
128MP0005391_vision/eye_phenotype0.80000266
129MP0005397_hematopoietic_system_phenotyp0.79552090
130MP0001545_abnormal_hematopoietic_system0.79552090
131MP0002109_abnormal_limb_morphology0.78781649
132MP0002177_abnormal_outer_ear0.78450974
133MP0003943_abnormal_hepatobiliary_system0.77289286
134MP0001340_abnormal_eyelid_morphology0.74546978
135* MP0002114_abnormal_axial_skeleton0.72746277

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the thymus (HP:0000778)4.43305148
2Short 4th metacarpal (HP:0010044)4.41570655
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.41570655
4Severe combined immunodeficiency (HP:0004430)4.09015127
5Panhypogammaglobulinemia (HP:0003139)3.79763026
6Combined immunodeficiency (HP:0005387)3.64042345
7Abnormality of the 4th metacarpal (HP:0010012)3.41189753
8Volvulus (HP:0002580)3.40391055
9Acute lymphatic leukemia (HP:0006721)3.19590019
10Macroorchidism (HP:0000053)3.07246973
11Subacute progressive viral hepatitis (HP:0006572)3.06837256
12Asymmetry of the thorax (HP:0001555)2.78161568
13Hyperacusis (HP:0010780)2.75943908
14Nephroblastoma (Wilms tumor) (HP:0002667)2.72179432
15Acute myeloid leukemia (HP:0004808)2.71513386
16Abnormality of the fingertips (HP:0001211)2.65747986
17Shallow orbits (HP:0000586)2.65161734
18Embryonal renal neoplasm (HP:0011794)2.57274506
19Renal duplication (HP:0000075)2.53349559
20Thyroid carcinoma (HP:0002890)2.52859383
21Medulloblastoma (HP:0002885)2.51379828
22Hypoproteinemia (HP:0003075)2.50798382
23Hepatoblastoma (HP:0002884)2.48989649
24Increased density of long bones (HP:0006392)2.36666069
25Cutis marmorata (HP:0000965)2.34912607
26Cystic hygroma (HP:0000476)2.33013972
27Abnormality of the left ventricular outflow tract (HP:0011103)2.32054215
28Subaortic stenosis (HP:0001682)2.32054215
29Increased nuchal translucency (HP:0010880)2.30374520
30Obsessive-compulsive behavior (HP:0000722)2.30001748
31Narrow palate (HP:0000189)2.29068043
32Heterotopia (HP:0002282)2.26900593
33Colon cancer (HP:0003003)2.26742754
34Renovascular hypertension (HP:0100817)2.25928964
35High anterior hairline (HP:0009890)2.25316303
36Elfin facies (HP:0004428)2.24907131
37Abnormality of chromosome segregation (HP:0002916)2.23516440
38Termporal pattern (HP:0011008)2.23404853
39Insidious onset (HP:0003587)2.23404853
40Rhabdomyosarcoma (HP:0002859)2.22775808
41Lymphangioma (HP:0100764)2.18754188
42Neoplasm of the adrenal cortex (HP:0100641)2.17919798
43Transitional cell carcinoma of the bladder (HP:0006740)2.15190224
44Chromsome breakage (HP:0040012)2.15073128
45Aortic aneurysm (HP:0004942)2.14917264
46Long clavicles (HP:0000890)2.14570991
47Abnormality of oral frenula (HP:0000190)2.13123507
48Drooling (HP:0002307)2.12419713
49Long eyelashes (HP:0000527)2.12132719
50Bowel diverticulosis (HP:0005222)2.11779570
51Hallux valgus (HP:0001822)2.11130163
52Deviation of the hallux (HP:0010051)2.10911264
53Aqueductal stenosis (HP:0002410)2.10295773
54Sacral dimple (HP:0000960)2.09093636
55Abnormality of the intervertebral disk (HP:0005108)2.08730311
56Ankyloglossia (HP:0010296)2.07675940
57Trigonocephaly (HP:0000243)2.06706200
58Sandal gap (HP:0001852)2.06626754
59Missing ribs (HP:0000921)2.06592302
60Spinal cord lesions (HP:0100561)2.06297492
61Syringomyelia (HP:0003396)2.06297492
62Absent frontal sinuses (HP:0002688)2.05025614
63Cortical dysplasia (HP:0002539)2.01652523
64Enlarged penis (HP:0000040)2.01498586
65Chromosomal breakage induced by crosslinking agents (HP:0003221)2.00120402
66Mitral valve prolapse (HP:0001634)2.00083695
67Curly hair (HP:0002212)1.99614488
68Broad ribs (HP:0000885)1.99163506
69Thyroiditis (HP:0100646)1.98300378
70Excessive salivation (HP:0003781)1.95226718
71Deep philtrum (HP:0002002)1.95127743
72Pelvic girdle muscle weakness (HP:0003749)1.94362327
73Hematochezia (HP:0002573)1.93842756
74Overriding aorta (HP:0002623)1.93255566
75Bladder carcinoma (HP:0002862)1.93100914
76Bladder neoplasm (HP:0009725)1.93100914
77Viral hepatitis (HP:0006562)1.92954342
78Large earlobe (HP:0009748)1.92725647
79Rectal prolapse (HP:0002035)1.92574996
80Abnormality of T cell number (HP:0011839)1.91536572
81Cerebral aneurysm (HP:0004944)1.91470450
82Aplasia/Hypoplasia of the sternum (HP:0006714)1.90921733
83Inappropriate behavior (HP:0000719)1.90497608
84Deviation of the thumb (HP:0009603)1.90306742
85Proximal placement of thumb (HP:0009623)1.90071433
86Broad palm (HP:0001169)1.89281460
87Papilledema (HP:0001085)1.88763112
88Malignant gastrointestinal tract tumors (HP:0006749)1.88676055
89Gastrointestinal carcinoma (HP:0002672)1.88676055
90Exostoses (HP:0100777)1.88195238
91Germ cell neoplasia (HP:0100728)1.88128714
92Embryonal neoplasm (HP:0002898)1.87395261
93Midline defect of the nose (HP:0004122)1.87364950
94Thick eyebrow (HP:0000574)1.85039235
95Uterine leiomyosarcoma (HP:0002891)1.84206951
96Leiomyosarcoma (HP:0100243)1.84206951
97Relative macrocephaly (HP:0004482)1.83501549
98Bicuspid aortic valve (HP:0001647)1.82858662
99Overlapping toe (HP:0001845)1.82496885
100Dilatation of the ascending aorta (HP:0005111)1.81467651
101Vertebral arch anomaly (HP:0008438)1.80050609
102Pointed chin (HP:0000307)1.80007398
103Erythroderma (HP:0001019)1.78929526
104Shoulder girdle muscle weakness (HP:0003547)1.77619078
105Eosinophilia (HP:0001880)1.77339072
106Neoplasm of the oral cavity (HP:0100649)1.77264114
107Abnormality of chromosome stability (HP:0003220)1.76422237
108Abnormality of the ischium (HP:0003174)1.76403445
109Buphthalmos (HP:0000557)1.75736839
110Abnormality of the astrocytes (HP:0100707)1.75577611
111Astrocytoma (HP:0009592)1.75577611
112Papillary thyroid carcinoma (HP:0002895)1.75447567
113Neoplasm of the small intestine (HP:0100833)1.74588120
114Deep palmar crease (HP:0006191)1.72291591
115Neoplasm of striated muscle (HP:0009728)1.71432016
116Papilloma (HP:0012740)1.71004778
117Verrucae (HP:0200043)1.71004778
118Vitreoretinal degeneration (HP:0000655)1.70531179
11911 pairs of ribs (HP:0000878)1.69864452
120Bladder diverticulum (HP:0000015)1.69643531
121B lymphocytopenia (HP:0010976)1.69471811
122Abnormality of B cell number (HP:0010975)1.69471811
123Smooth philtrum (HP:0000319)1.69371493
124Flat cornea (HP:0007720)1.69334782
125Thickened helices (HP:0000391)1.69294916
126Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.68547202
127Fibrous tissue neoplasm (HP:0012316)1.67433012
128Intestinal atresia (HP:0011100)1.67059157
129Skull defect (HP:0001362)1.66163482
130Disinhibition (HP:0000734)1.65919820
131Abnormality of the hip-girdle musculature (HP:0001445)1.65299170
132Abnormality of the musculature of the pelvis (HP:0001469)1.65299170
133Abnormality of the thymus (HP:0000777)1.63711120
134Truncal obesity (HP:0001956)1.63668746
135Tented upper lip vermilion (HP:0010804)1.63549044
136Broad thumb (HP:0011304)1.63310215
137Megalencephaly (HP:0001355)1.62778065
138Cutaneous finger syndactyly (HP:0010554)1.61967584
139Cafe-au-lait spot (HP:0000957)1.61837508
140Overgrowth (HP:0001548)1.61433560
141Glioma (HP:0009733)1.60861663
142Exotropia (HP:0000577)1.60846412
143Abnormality of the corticospinal tract (HP:0002492)1.60401683
144Aortic dissection (HP:0002647)1.59561599
145Hypoplasia of the maxilla (HP:0000327)1.59517372
146Omphalocele (HP:0001539)1.59254409
147Cutaneous syndactyly (HP:0012725)1.59063176
148Protruding tongue (HP:0010808)1.58764576
149Insomnia (HP:0100785)1.58621458
150Aplasia/Hypoplasia of the thymus (HP:0010515)1.58085509
151Protrusio acetabuli (HP:0003179)1.57788829
152Abnormal lung lobation (HP:0002101)1.57670183
153Increased number of teeth (HP:0011069)1.57393475
154Persistence of primary teeth (HP:0006335)1.57146456
155T lymphocytopenia (HP:0005403)1.55090097
156Dislocated radial head (HP:0003083)1.54689359
157Partial agenesis of the corpus callosum (HP:0001338)1.51433678
158Facial hemangioma (HP:0000329)1.50472065
159Pulmonic stenosis (HP:0001642)1.50270418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K103.67687218
2EEF2K3.58569702
3MARK13.07897051
4FGFR22.91651032
5PKN22.67619182
6ERBB32.65997938
7TRIB32.39153614
8CASK2.27684323
9SIK22.18487742
10PDGFRA2.08162728
11PNCK1.98682896
12FGFR31.96807405
13CDC71.75726370
14CDK121.73396065
15CAMK1G1.72993150
16KSR11.72531448
17TNIK1.69144949
18LATS11.67182141
19PTK61.67063200
20EIF2AK31.66287713
21TGFBR11.62380300
22CDK61.61595610
23EPHB21.59960029
24TTK1.51369637
25BRD41.48168690
26TAF11.43094693
27NLK1.42066459
28SCYL21.39709337
29FRK1.38947730
30TYRO31.36574996
31CAMK1D1.34029646
32TTN1.32633697
33FGFR11.28140232
34PDGFRB1.28039436
35SIK11.23616657
36CSNK1A1L1.21682559
37PLK41.20632949
38NTRK21.19006618
39NEK21.16824185
40DYRK1B1.15300311
41RIPK11.14539904
42RET1.10289491
43ICK1.05852460
44YES11.04376431
45PASK1.04320988
46ITK1.01315337
47FGFR40.99560764
48SIK30.98788250
49CDK30.96000096
50MKNK10.95938092
51BCR0.95779154
52DMPK0.95495670
53LRRK20.95307220
54DYRK30.94808847
55CSNK1G20.91156261
56CDK90.90665089
57AKT30.90155704
58RPS6KB20.88209162
59MAPK130.88144568
60MTOR0.86394985
61DDR20.86166892
62LATS20.86144003
63WNK10.85171348
64NUAK10.82409389
65HIPK20.81944152
66CSNK1G10.80410822
67CSNK1G30.79722778
68STK100.79145904
69ATR0.78200310
70CDK70.77900195
71MAP4K10.76921652
72CHEK20.76835750
73MAPK100.76618725
74MAP3K60.76465290
75GRK60.74702031
76PRKCH0.74347869
77STK30.74210254
78PBK0.74206917
79SRPK10.72983071
80ALK0.71787527
81WEE10.71010415
82EPHA30.70855348
83SGK2230.69641698
84SGK4940.69641698
85TIE10.69482161
86SGK30.68965667
87PAK20.67895594
88CDK40.67613748
89ERBB20.66949989
90TGFBR20.66495765
91EPHA40.66455853
92MAP2K40.66362027
93DYRK20.66358487
94TSSK60.63105525
95ILK0.62856130
96MET0.60387618
97CLK10.59772694
98CSNK1D0.58715574
99MAP3K40.57977362
100NEK10.57253148
101RPS6KA20.55164515
102CCNB10.55081339
103MARK20.54936062
104CSF1R0.54064957
105EIF2AK20.53846788
106ATM0.53782742
107MAP2K70.53451923
108PAK30.53402019
109MAPK90.53326064
110CHEK10.52846918
111UHMK10.52586615
112RPS6KA40.52041034
113* CSNK1E0.51352667
114GSK3B0.51083604
115RPS6KB10.49998648
116PRKD30.49305965
117PLK30.49229034
118MAP3K70.49028927
119MELK0.48664028
120SGK20.48249871
121BMPR1B0.47983168
122SMG10.47594004
123CAMK40.47044444
124FLT30.45254998
125HCK0.45171150
126* CDK10.44983413
127FYN0.44882009
128STK40.44568221
129CDK20.44419695
130MAPK80.43966500
131NTRK10.43739283
132PLK20.43118226
133PRKDC0.41582052
134STK110.41406253
135BRSK20.41071118
136ROCK10.40572431
137MKNK20.39004925
138MAPK140.38812189
139CHUK0.37914558
140INSR0.35158615
141MINK10.34878792
142DYRK1A0.34850487
143AKT10.34714456

Predicted pathways (KEGG)

RankGene SetZ-score
1Chronic myeloid leukemia_Homo sapiens_hsa052201.92230024
2Colorectal cancer_Homo sapiens_hsa052101.91781709
3Endometrial cancer_Homo sapiens_hsa052131.75767995
4MicroRNAs in cancer_Homo sapiens_hsa052061.65339835
5RNA transport_Homo sapiens_hsa030131.64445004
6Viral myocarditis_Homo sapiens_hsa054161.63072293
7Axon guidance_Homo sapiens_hsa043601.55681271
8Non-small cell lung cancer_Homo sapiens_hsa052231.53733650
9mTOR signaling pathway_Homo sapiens_hsa041501.52038514
10Glioma_Homo sapiens_hsa052141.51747177
11Primary immunodeficiency_Homo sapiens_hsa053401.47349140
12Pancreatic cancer_Homo sapiens_hsa052121.45791451
13DNA replication_Homo sapiens_hsa030301.45595802
14Mismatch repair_Homo sapiens_hsa034301.44196339
15Adherens junction_Homo sapiens_hsa045201.43441567
16T cell receptor signaling pathway_Homo sapiens_hsa046601.40918757
17Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.39696247
18B cell receptor signaling pathway_Homo sapiens_hsa046621.39366976
19Basal cell carcinoma_Homo sapiens_hsa052171.37101915
20Proteoglycans in cancer_Homo sapiens_hsa052051.35463274
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.34972722
22Small cell lung cancer_Homo sapiens_hsa052221.34566232
23mRNA surveillance pathway_Homo sapiens_hsa030151.30990538
24Focal adhesion_Homo sapiens_hsa045101.30443128
25Systemic lupus erythematosus_Homo sapiens_hsa053221.24524040
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.24057960
27Hippo signaling pathway_Homo sapiens_hsa043901.23914381
28Notch signaling pathway_Homo sapiens_hsa043301.22634131
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.22061171
30Renal cell carcinoma_Homo sapiens_hsa052111.21904550
31Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18693008
32Thyroid hormone signaling pathway_Homo sapiens_hsa049191.18405265
33Alcoholism_Homo sapiens_hsa050341.16959417
34Prostate cancer_Homo sapiens_hsa052151.16787133
35Fanconi anemia pathway_Homo sapiens_hsa034601.16287860
36Cell cycle_Homo sapiens_hsa041101.15822761
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15559745
38HTLV-I infection_Homo sapiens_hsa051661.13058758
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12397359
40Wnt signaling pathway_Homo sapiens_hsa043101.10396777
41Viral carcinogenesis_Homo sapiens_hsa052031.09534675
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.09508078
43Platelet activation_Homo sapiens_hsa046111.06659674
44ErbB signaling pathway_Homo sapiens_hsa040121.06108711
45Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06057948
46Hepatitis B_Homo sapiens_hsa051611.05407530
47Lysine degradation_Homo sapiens_hsa003101.04951442
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03969957
49Long-term depression_Homo sapiens_hsa047301.03520232
50Estrogen signaling pathway_Homo sapiens_hsa049151.03201571
51Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.02934150
52Leukocyte transendothelial migration_Homo sapiens_hsa046701.01786687
53VEGF signaling pathway_Homo sapiens_hsa043701.01062492
54Inositol phosphate metabolism_Homo sapiens_hsa005621.00255683
55FoxO signaling pathway_Homo sapiens_hsa040680.98687002
56TGF-beta signaling pathway_Homo sapiens_hsa043500.97397326
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97391344
58Pathways in cancer_Homo sapiens_hsa052000.93274309
59Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.92844095
60Dorso-ventral axis formation_Homo sapiens_hsa043200.92798368
61Acute myeloid leukemia_Homo sapiens_hsa052210.92129682
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89815351
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89802256
64Nucleotide excision repair_Homo sapiens_hsa034200.88881169
65Hedgehog signaling pathway_Homo sapiens_hsa043400.88723606
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.87383943
67Rap1 signaling pathway_Homo sapiens_hsa040150.85565912
68Long-term potentiation_Homo sapiens_hsa047200.85007352
69Toxoplasmosis_Homo sapiens_hsa051450.84976053
70Spliceosome_Homo sapiens_hsa030400.84817122
71Type II diabetes mellitus_Homo sapiens_hsa049300.84582092
72Central carbon metabolism in cancer_Homo sapiens_hsa052300.83948626
73Gap junction_Homo sapiens_hsa045400.83503517
74Prolactin signaling pathway_Homo sapiens_hsa049170.82785778
75Melanogenesis_Homo sapiens_hsa049160.82420664
76Basal transcription factors_Homo sapiens_hsa030220.81995100
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81523244
78Choline metabolism in cancer_Homo sapiens_hsa052310.81148508
79Amphetamine addiction_Homo sapiens_hsa050310.80951233
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.80281944
81Oocyte meiosis_Homo sapiens_hsa041140.80001030
82ECM-receptor interaction_Homo sapiens_hsa045120.79483257
83Dopaminergic synapse_Homo sapiens_hsa047280.78477960
84AMPK signaling pathway_Homo sapiens_hsa041520.78256864
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77453100
86Osteoclast differentiation_Homo sapiens_hsa043800.76789829
87Insulin resistance_Homo sapiens_hsa049310.76015525
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.75449606
89Cholinergic synapse_Homo sapiens_hsa047250.74321665
90Nicotine addiction_Homo sapiens_hsa050330.73797677
91Chemokine signaling pathway_Homo sapiens_hsa040620.73624468
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73587952
93Glutamatergic synapse_Homo sapiens_hsa047240.73496738
94Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73284918
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.73249456
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72743278
97Insulin signaling pathway_Homo sapiens_hsa049100.72708286
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72200230
99Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72113028
100MAPK signaling pathway_Homo sapiens_hsa040100.71511015
101Melanoma_Homo sapiens_hsa052180.71379558
102Oxytocin signaling pathway_Homo sapiens_hsa049210.71065648
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69942251
104Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.69678251
105Non-homologous end-joining_Homo sapiens_hsa034500.69575337
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69420469
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.69238010
108Thyroid cancer_Homo sapiens_hsa052160.69232257
109GnRH signaling pathway_Homo sapiens_hsa049120.68567797
110Measles_Homo sapiens_hsa051620.68119637
111Phototransduction_Homo sapiens_hsa047440.64959502
112Renin secretion_Homo sapiens_hsa049240.64595710
113Tight junction_Homo sapiens_hsa045300.64425214
114Circadian entrainment_Homo sapiens_hsa047130.64131911
115Base excision repair_Homo sapiens_hsa034100.63884803
116RNA degradation_Homo sapiens_hsa030180.63812228
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.61558870
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.61179517
119Thyroid hormone synthesis_Homo sapiens_hsa049180.59675936
120Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59133491
121Ras signaling pathway_Homo sapiens_hsa040140.58215250
122Cocaine addiction_Homo sapiens_hsa050300.57036494
123cAMP signaling pathway_Homo sapiens_hsa040240.56498064
124Taste transduction_Homo sapiens_hsa047420.55336565
125Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48632800

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