TOP1MT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial DNA topoisomerase that plays a role in the modification of DNA topology. The encoded protein is a type IB topoisomerase and catalyzes the transient breaking and rejoining of DNA to relieve tension and DNA supercoiling generated in the mitochondrial genome during replication and transcription. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.93479178
2proline metabolic process (GO:0006560)8.34092584
3transcription from mitochondrial promoter (GO:0006390)7.31621294
4embryonic process involved in female pregnancy (GO:0060136)6.25323481
5replication fork processing (GO:0031297)6.07675460
6sulfur amino acid catabolic process (GO:0000098)5.99652873
7DNA deamination (GO:0045006)5.53248435
8glutamine family amino acid biosynthetic process (GO:0009084)5.45094006
9oxidative demethylation (GO:0070989)5.37683421
10negative regulation of fatty acid biosynthetic process (GO:0045717)5.32463633
11positive regulation of protein homooligomerization (GO:0032464)5.32143230
12ribosomal small subunit biogenesis (GO:0042274)5.25527009
13DNA unwinding involved in DNA replication (GO:0006268)4.99929089
14regulation of protein homooligomerization (GO:0032462)4.98662807
15L-phenylalanine metabolic process (GO:0006558)4.93315150
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.93315150
17viral transcription (GO:0019083)4.91068519
18maturation of SSU-rRNA (GO:0030490)4.84816866
19ribosomal small subunit assembly (GO:0000028)4.78705216
20maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.76756911
21translational termination (GO:0006415)4.67925455
22glyoxylate metabolic process (GO:0046487)4.65525128
23regulation of integrin activation (GO:0033623)4.65513654
24establishment of apical/basal cell polarity (GO:0035089)4.59568349
25mitochondrial DNA metabolic process (GO:0032042)4.57085888
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.42632584
27L-phenylalanine catabolic process (GO:0006559)4.42632584
28DNA strand elongation involved in DNA replication (GO:0006271)4.30584288
29ribosomal large subunit biogenesis (GO:0042273)4.26695033
30very-low-density lipoprotein particle assembly (GO:0034379)4.24845494
31mitotic G1 DNA damage checkpoint (GO:0031571)4.24714740
32translational elongation (GO:0006414)4.23674417
33nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.17124577
34DNA strand elongation (GO:0022616)4.15573399
35DNA strand renaturation (GO:0000733)4.11028895
36ribonucleoprotein complex biogenesis (GO:0022613)4.10052720
37heme transport (GO:0015886)4.04979131
38alkaloid metabolic process (GO:0009820)4.04896347
39SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.04817685
40somatic hypermutation of immunoglobulin genes (GO:0016446)4.02434734
41somatic diversification of immune receptors via somatic mutation (GO:0002566)4.02434734
42translational initiation (GO:0006413)3.99976921
43DNA replication initiation (GO:0006270)3.96649257
44establishment or maintenance of monopolar cell polarity (GO:0061339)3.96531482
45establishment of monopolar cell polarity (GO:0061162)3.96531482
46protein targeting to ER (GO:0045047)3.92420953
47cotranslational protein targeting to membrane (GO:0006613)3.92345842
48serine family amino acid catabolic process (GO:0009071)3.89600586
49mitotic G1/S transition checkpoint (GO:0044819)3.85266804
50embryonic placenta development (GO:0001892)3.84722576
51nuclear pore complex assembly (GO:0051292)3.82628871
52viral life cycle (GO:0019058)3.80837095
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.78844344
54establishment of protein localization to endoplasmic reticulum (GO:0072599)3.75588568
55ribosome biogenesis (GO:0042254)3.74844152
56aromatic amino acid family catabolic process (GO:0009074)3.74378023
57negative regulation of protein oligomerization (GO:0032460)3.69953909
58protein localization to endoplasmic reticulum (GO:0070972)3.69616210
59cysteine metabolic process (GO:0006534)3.68190188
60cytolysis (GO:0019835)3.66477039
61G1 DNA damage checkpoint (GO:0044783)3.65871308
62poly(A)+ mRNA export from nucleus (GO:0016973)3.65173818
63triglyceride homeostasis (GO:0070328)3.64470839
64acylglycerol homeostasis (GO:0055090)3.64470839
65regulation of translational fidelity (GO:0006450)3.62186873
66establishment of protein localization to mitochondrial membrane (GO:0090151)3.61907416
67mitotic chromosome condensation (GO:0007076)3.61826883
68cellular protein complex disassembly (GO:0043624)3.61365146
69positive regulation of developmental pigmentation (GO:0048087)3.57131276
70regulation of cholesterol homeostasis (GO:2000188)3.56812880
71intestinal cholesterol absorption (GO:0030299)3.55368357
72negative regulation of fatty acid metabolic process (GO:0045922)3.50482196
73viral mRNA export from host cell nucleus (GO:0046784)3.49515640
74regulation of mitochondrial translation (GO:0070129)3.47350166
75protein complex disassembly (GO:0043241)3.47091687
76bile acid metabolic process (GO:0008206)3.45139374
77bile acid biosynthetic process (GO:0006699)3.44737900
78negative regulation of cell cycle arrest (GO:0071157)3.44407871
79cellular response to ATP (GO:0071318)3.43080615
80negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.39152204
81peptidyl-arginine omega-N-methylation (GO:0035247)3.37804206
82kynurenine metabolic process (GO:0070189)3.37041251
83negative regulation of JAK-STAT cascade (GO:0046426)3.36234598
84ribosome assembly (GO:0042255)3.36102521
85mRNA cleavage (GO:0006379)3.33583825
86telomere maintenance via recombination (GO:0000722)3.33276948
87triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.33017433
88acetyl-CoA metabolic process (GO:0006084)3.32721555
89glycine metabolic process (GO:0006544)3.32622734
90mitochondrial RNA metabolic process (GO:0000959)3.30441716
91establishment of integrated proviral latency (GO:0075713)3.29001159
92negative regulation of RNA splicing (GO:0033119)3.28587889
93cholesterol efflux (GO:0033344)3.28361146
94serine family amino acid metabolic process (GO:0009069)3.28230173
95nuclear pore organization (GO:0006999)3.27915762
96formation of translation preinitiation complex (GO:0001731)3.25845247
97macromolecular complex disassembly (GO:0032984)3.25474172
98alpha-linolenic acid metabolic process (GO:0036109)3.24845116
99negative regulation of mRNA metabolic process (GO:1903312)3.24126776
100nucleobase biosynthetic process (GO:0046112)3.23920289
101L-ascorbic acid metabolic process (GO:0019852)3.20348341
102negative regulation of mRNA processing (GO:0050686)3.20281022
103folic acid metabolic process (GO:0046655)3.19218932
104histone arginine methylation (GO:0034969)3.18714546
105IMP biosynthetic process (GO:0006188)3.18038481
106mitotic recombination (GO:0006312)3.14552208
107tryptophan catabolic process (GO:0006569)3.13544376
108indole-containing compound catabolic process (GO:0042436)3.13544376
109indolalkylamine catabolic process (GO:0046218)3.13544376
110regulation of protein oligomerization (GO:0032459)3.12417276
111translation (GO:0006412)3.12102258
112* DNA topological change (GO:0006265)3.10965620
113positive regulation of protein oligomerization (GO:0032461)3.09789521
114spliceosomal tri-snRNP complex assembly (GO:0000244)3.07485589
115rRNA transcription (GO:0009303)3.06869007
116plasma lipoprotein particle assembly (GO:0034377)3.06546827
117serine family amino acid biosynthetic process (GO:0009070)3.06351208
118heterochromatin organization (GO:0070828)3.05307952
119negative regulation of fibrinolysis (GO:0051918)3.05257591
120pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.04636601
121lysine metabolic process (GO:0006553)3.04525519
122lysine catabolic process (GO:0006554)3.04525519
123rRNA processing (GO:0006364)3.02984689
124DNA duplex unwinding (GO:0032508)3.01545618
125telomere maintenance via semi-conservative replication (GO:0032201)3.00944899
126mitotic nuclear envelope disassembly (GO:0007077)3.00431970
127purine nucleobase biosynthetic process (GO:0009113)3.00097103
128folic acid-containing compound biosynthetic process (GO:0009396)2.98828682
129regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98510751
130cellular amino acid catabolic process (GO:0009063)2.97433350
131alpha-amino acid catabolic process (GO:1901606)2.95609763
132GDP-mannose metabolic process (GO:0019673)2.95360969
133pore complex assembly (GO:0046931)2.94984220
134nucleobase-containing small molecule interconversion (GO:0015949)2.94970811
135nuclear-transcribed mRNA catabolic process (GO:0000956)2.94830149
136positive regulation by host of viral transcription (GO:0043923)2.94700704
137base-excision repair (GO:0006284)2.94542356
138mitotic sister chromatid segregation (GO:0000070)2.94499700
139pseudouridine synthesis (GO:0001522)2.92905512
140tryptophan metabolic process (GO:0006568)2.92325357
141pentose metabolic process (GO:0019321)2.91438256
142aromatic amino acid family metabolic process (GO:0009072)2.90047963
143urea cycle (GO:0000050)2.90021674
144urea metabolic process (GO:0019627)2.90021674
145cellular component biogenesis (GO:0044085)2.89880532
146dosage compensation (GO:0007549)2.89560029
147negative regulation of Ras GTPase activity (GO:0034261)2.89196247
148RNA catabolic process (GO:0006401)2.88104225
149regulation of mitochondrial depolarization (GO:0051900)2.87715738
150peptidyl-glutamic acid carboxylation (GO:0017187)2.87495855
151protein carboxylation (GO:0018214)2.87495855
152mRNA catabolic process (GO:0006402)2.86999233
153rRNA metabolic process (GO:0016072)2.86963637
154DNA geometric change (GO:0032392)2.86774070
155high-density lipoprotein particle remodeling (GO:0034375)2.86542316
156protein localization to chromosome, centromeric region (GO:0071459)2.85841467
157mRNA splicing, via spliceosome (GO:0000398)2.85685257
158RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85685257
159cellular response to zinc ion (GO:0071294)2.85266003
160pentose-phosphate shunt (GO:0006098)2.84455078
161IMP metabolic process (GO:0046040)2.84005426
162DNA replication checkpoint (GO:0000076)2.83548634
163regulation of RNA export from nucleus (GO:0046831)2.83164739
164L-serine metabolic process (GO:0006563)2.82758331
165protein-DNA complex disassembly (GO:0032986)2.80326628
166nucleosome disassembly (GO:0006337)2.80326628
167RNA splicing, via transesterification reactions (GO:0000375)2.80226587
168NAD biosynthetic process (GO:0009435)2.79679179
169base-excision repair, AP site formation (GO:0006285)2.79520403
170fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.78841115
171labyrinthine layer development (GO:0060711)2.78708291
172DNA integration (GO:0015074)2.78330494
173peptidyl-arginine N-methylation (GO:0035246)2.77149213
174peptidyl-arginine methylation (GO:0018216)2.77149213
175protein targeting to membrane (GO:0006612)2.76151346
176sister chromatid segregation (GO:0000819)2.75440667
177DNA synthesis involved in DNA repair (GO:0000731)2.75246535
178regulation of histone H3-K9 methylation (GO:0051570)2.74603282
1793-UTR-mediated mRNA stabilization (GO:0070935)2.72346565
180nuclear envelope disassembly (GO:0051081)2.72205116
181membrane disassembly (GO:0030397)2.72205116
182tRNA aminoacylation for protein translation (GO:0006418)2.71227834
183regulation of translational termination (GO:0006449)2.70849310
184ncRNA 3-end processing (GO:0043628)2.68640456
185telomere maintenance via telomere lengthening (GO:0010833)2.68090802
186protoporphyrinogen IX metabolic process (GO:0046501)2.67672516
187mitotic metaphase plate congression (GO:0007080)2.66400913
188* DNA conformation change (GO:0071103)2.66247490
189protein complex localization (GO:0031503)2.65560503
190spliceosomal snRNP assembly (GO:0000387)2.65501462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.38305741
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.64108493
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.12006528
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.47000144
5HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.33338121
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.91378248
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.75676779
8SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.75092306
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.63393115
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.50298500
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.41773562
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.40361635
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.37915960
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.35627201
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.33289423
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.29906256
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.29906256
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.29906256
19XRN2_22483619_ChIP-Seq_HELA_Human2.29344897
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.26614333
21ZNF263_19887448_ChIP-Seq_K562_Human2.24172228
22VDR_21846776_ChIP-Seq_THP-1_Human2.17102075
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.16112122
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14958198
25* LXR_22292898_ChIP-Seq_THP-1_Human2.14314075
26ERG_21242973_ChIP-ChIP_JURKAT_Human2.13836053
27DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.09224078
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.06239142
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.04921198
30STAT3_1855785_ChIP-Seq_MESCs_Mouse2.04870963
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.02919376
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01228574
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00545078
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95586150
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95228033
36EGR1_19374776_ChIP-ChIP_THP-1_Human1.94833822
37NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.94576895
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.91401453
39KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.88119648
40SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.86830943
41NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.84828778
42* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.80029463
43EGR1_23403033_ChIP-Seq_LIVER_Mouse1.79519806
44TTF2_22483619_ChIP-Seq_HELA_Human1.78890370
45CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.78844584
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.77528048
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.75686353
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75341636
49* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.75259430
50MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72355187
51ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70365043
52* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.70319901
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.68957266
54SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.68235695
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.65830659
56TET1_21451524_ChIP-Seq_MESCs_Mouse1.64472811
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.62987680
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62324766
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.59001864
60FOXP3_21729870_ChIP-Seq_TREG_Human1.56926224
61CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.54198290
62TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49125011
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48806317
64RARB_24833708_ChIP-Seq_LIVER_Mouse1.47478860
65CIITA_25753668_ChIP-Seq_RAJI_Human1.47270456
66ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.46563802
67RACK7_27058665_Chip-Seq_MCF-7_Human1.45637100
68SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.44444560
69* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42994201
70CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.42181548
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40048737
72E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38639210
73* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38444998
74JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.38010794
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37582498
76RARA_24833708_ChIP-Seq_LIVER_Mouse1.36413358
77BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.35432058
78NANOG_21062744_ChIP-ChIP_HESCs_Human1.35216693
79TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.34712858
80KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34154858
81ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.33908591
82SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.33858979
83TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32942971
84NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32816054
85ERG_20887958_ChIP-Seq_HPC-7_Mouse1.32108856
86VDR_23849224_ChIP-Seq_CD4+_Human1.30120054
87TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.29364251
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.26912407
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.26897520
90TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.26045915
91NCOR1_26117541_ChIP-Seq_K562_Human1.25988816
92ETS1_21867929_ChIP-Seq_TH2_Mouse1.25861094
93VDR_24763502_ChIP-Seq_THP-1_Human1.25015320
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23125645
95THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22781335
96MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.22177320
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21697425
98SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21445873
99POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.21420286
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.21019406
101SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.18813668
102SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18600087
103* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.18351287
104* TFEB_21752829_ChIP-Seq_HELA_Human1.16469307
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16436429
106* SRF_21415370_ChIP-Seq_HL-1_Mouse1.15838986
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.14607568
108GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.14293639
109AR_21909140_ChIP-Seq_LNCAP_Human1.14171119
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13829618
111CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.12810049
112SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12539322
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11318101
114SPI1_26923725_Chip-Seq_HPCs_Mouse1.11131695
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11063945
116OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09530524
117MYC_22102868_ChIP-Seq_BL_Human1.07635354
118* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07166777
119PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07130467
120DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06986663
121THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06172719
122TCF7_22412390_ChIP-Seq_EML_Mouse1.05267781
123E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05229462
124SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04908686
125CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.04430971
126SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04201956
127ELK3_25401928_ChIP-Seq_HUVEC_Human1.04065691
128* BCOR_27268052_Chip-Seq_Bcells_Human1.04013705
129NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03974782
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03900295
131DCP1A_22483619_ChIP-Seq_HELA_Human1.02608507
132KDM5A_27292631_Chip-Seq_BREAST_Human1.02436209
133ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02273914
134KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.01354561
135GABP_19822575_ChIP-Seq_HepG2_Human1.00976344
136E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.00866914
137MAF_26560356_Chip-Seq_TH1_Human1.00212995
138UTX_26944678_Chip-Seq_JUKART_Human0.99930319
139STAT1_20625510_ChIP-Seq_HELA_Human0.98771119
140KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.98444950
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98316347
142KDM2B_26808549_Chip-Seq_SUP-B15_Human0.98143518
143ZFX_18555785_ChIP-Seq_MESCs_Mouse0.97705980
144CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.97379952
145PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97289138
146MAF_26560356_Chip-Seq_TH2_Human0.96941520
147POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96497537
148ETS1_20019798_ChIP-Seq_JURKAT_Human0.96235423
149MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96203773
150SPI1_23547873_ChIP-Seq_NB4_Human0.96152804
151KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.95737545
152NANOG_18692474_ChIP-Seq_MESCs_Mouse0.95554048
153CTCF_27219007_Chip-Seq_ERYTHROID_Human0.95462367
154CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95301851
155* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94995603
156SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94224360
157KDM2B_26808549_Chip-Seq_DND41_Human0.93331991
158NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.93199959
159E2F1_20622854_ChIP-Seq_HELA_Human0.93155715
160* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93152355
161SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.93001552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.17843530
2MP0005085_abnormal_gallbladder_physiolo5.05380117
3MP0005365_abnormal_bile_salt4.82805389
4MP0005360_urolithiasis4.65644784
5MP0008057_abnormal_DNA_replication4.49619037
6MP0003111_abnormal_nucleus_morphology4.00188390
7MP0003693_abnormal_embryo_hatching3.98208283
8MP0003806_abnormal_nucleotide_metabolis3.64062391
9MP0005171_absent_coat_pigmentation3.58279108
10MP0002396_abnormal_hematopoietic_system3.30346224
11MP0009278_abnormal_bone_marrow3.12292336
12MP0003077_abnormal_cell_cycle3.08113463
13MP0004233_abnormal_muscle_weight3.08067380
14MP0010030_abnormal_orbit_morphology2.71128301
15MP0008875_abnormal_xenobiotic_pharmacok2.65543028
16MP0008007_abnormal_cellular_replicative2.51231780
17MP0001730_embryonic_growth_arrest2.31572339
18MP0005332_abnormal_amino_acid2.29004859
19MP0004185_abnormal_adipocyte_glucose2.28703827
20MP0000350_abnormal_cell_proliferation2.11470999
21MP0004808_abnormal_hematopoietic_stem2.10548526
22MP0002009_preneoplasia1.98175590
23MP0009840_abnormal_foam_cell1.95887358
24MP0010329_abnormal_lipoprotein_level1.88042357
25MP0004019_abnormal_vitamin_homeostasis1.87809484
26MP0005075_abnormal_melanosome_morpholog1.84850544
27MP0003252_abnormal_bile_duct1.83964140
28MP0001545_abnormal_hematopoietic_system1.78013179
29MP0005397_hematopoietic_system_phenotyp1.78013179
30MP0008995_early_reproductive_senescence1.72639055
31MP0003656_abnormal_erythrocyte_physiolo1.70219743
32MP0002877_abnormal_melanocyte_morpholog1.66303683
33MP0008260_abnormal_autophagy1.65470575
34MP0000313_abnormal_cell_death1.61624300
35MP0003453_abnormal_keratinocyte_physiol1.60843530
36MP0003984_embryonic_growth_retardation1.58605431
37MP0005058_abnormal_lysosome_morphology1.55626738
38MP0000609_abnormal_liver_physiology1.55182896
39MP0001666_abnormal_nutrient_absorption1.53225947
40MP0004133_heterotaxia1.52933847
41MP0002088_abnormal_embryonic_growth/wei1.49971118
42MP0003191_abnormal_cellular_cholesterol1.49568833
43MP0000678_abnormal_parathyroid_gland1.47582014
44MP0005083_abnormal_biliary_tract1.47329387
45MP0002269_muscular_atrophy1.42539846
46MP0000579_abnormal_nail_morphology1.40399269
47MP0000639_abnormal_adrenal_gland1.38568874
48MP0002118_abnormal_lipid_homeostasis1.36973205
49MP0009379_abnormal_foot_pigmentation1.36655072
50MP0006035_abnormal_mitochondrial_morpho1.36578231
51MP0003890_abnormal_embryonic-extraembry1.36448782
52MP0009672_abnormal_birth_weight1.34446795
53MP0005319_abnormal_enzyme/_coenzyme1.32947125
54MP0001764_abnormal_homeostasis1.31710793
55MP0010307_abnormal_tumor_latency1.28568630
56MP0000703_abnormal_thymus_morphology1.28053637
57MP0009697_abnormal_copulation1.25538783
58MP0006072_abnormal_retinal_apoptosis1.24256263
59MP0002282_abnormal_trachea_morphology1.24186611
60MP0002249_abnormal_larynx_morphology1.24093794
61MP0000371_diluted_coat_color1.19966746
62MP0003705_abnormal_hypodermis_morpholog1.19669956
63MP0002796_impaired_skin_barrier1.19293999
64MP0005266_abnormal_metabolism1.18086519
65MP0000358_abnormal_cell_content/1.16441869
66MP0003786_premature_aging1.15839209
67MP0010352_gastrointestinal_tract_polyps1.15377510
68MP0006292_abnormal_olfactory_placode1.14578096
69MP0003172_abnormal_lysosome_physiology1.14106348
70MP0010094_abnormal_chromosome_stability1.13459013
71MP0002132_abnormal_respiratory_system1.12967079
72MP0002086_abnormal_extraembryonic_tissu1.12662470
73MP0005666_abnormal_adipose_tissue1.11906200
74MP0003718_maternal_effect1.11083460
75MP0001853_heart_inflammation1.10795440
76MP0000537_abnormal_urethra_morphology1.10726288
77MP0003283_abnormal_digestive_organ1.10116968
78MP0001661_extended_life_span1.09901981
79MP0003119_abnormal_digestive_system1.09002316
80MP0002722_abnormal_immune_system1.08212502
81MP0003315_abnormal_perineum_morphology1.07233444
82MP0003763_abnormal_thymus_physiology1.04997905
83MP0002398_abnormal_bone_marrow1.04292699
84MP0006036_abnormal_mitochondrial_physio0.99234235
85MP0009931_abnormal_skin_appearance0.98914984
86MP0000598_abnormal_liver_morphology0.98186230
87MP0005621_abnormal_cell_physiology0.97741387
88MP0005174_abnormal_tail_pigmentation0.95700860
89MP0005384_cellular_phenotype0.95268886
90MP0009115_abnormal_fat_cell0.95265597
91MP0001873_stomach_inflammation0.95213188
92MP0004197_abnormal_fetal_growth/weight/0.94690634
93MP0001697_abnormal_embryo_size0.94091867
94MP0004782_abnormal_surfactant_physiolog0.93367124
95MP0005451_abnormal_body_composition0.93192610
96MP0001293_anophthalmia0.92929786
97MP0000689_abnormal_spleen_morphology0.91526387
98MP0001324_abnormal_eye_pigmentation0.91378342
99MP0009053_abnormal_anal_canal0.91172822
100MP0001340_abnormal_eyelid_morphology0.91159573
101MP0000470_abnormal_stomach_morphology0.90933363
102MP0005584_abnormal_enzyme/coenzyme_acti0.90515294
103MP0005647_abnormal_sex_gland0.90495115
104MP0000858_altered_metastatic_potential0.89822163
105MP0005376_homeostasis/metabolism_phenot0.89180472
106MP0002971_abnormal_brown_adipose0.87904892
107MP0002429_abnormal_blood_cell0.86574737
108MP0001881_abnormal_mammary_gland0.85459211
109MP0004957_abnormal_blastocyst_morpholog0.85033892
110MP0002653_abnormal_ependyma_morphology0.84690110
111MP0006082_CNS_inflammation0.84339600
112MP0003638_abnormal_response/metabolism_0.83127080
113MP0002084_abnormal_developmental_patter0.82705199
114MP0003186_abnormal_redox_activity0.82433584
115MP0005330_cardiomyopathy0.82177436
116MP0003221_abnormal_cardiomyocyte_apopto0.81215417
117MP0003567_abnormal_fetal_cardiomyocyte0.80913011
118MP0000462_abnormal_digestive_system0.80728369
119MP0003195_calcinosis0.79199709
120MP0004142_abnormal_muscle_tone0.79101601
121MP0008877_abnormal_DNA_methylation0.78980480
122MP0002210_abnormal_sex_determination0.77674924
123MP0002970_abnormal_white_adipose0.76578473
124MP0005076_abnormal_cell_differentiation0.75996462
125MP0005464_abnormal_platelet_physiology0.74871624
126MP0001145_abnormal_male_reproductive0.74343143
127MP0002060_abnormal_skin_morphology0.73906250
128MP0004264_abnormal_extraembryonic_tissu0.73632357
129MP0008932_abnormal_embryonic_tissue0.73419419
130MP0002111_abnormal_tail_morphology0.69904979
131MP0001929_abnormal_gametogenesis0.68376737
132MP0003941_abnormal_skin_development0.68367733
133MP0002085_abnormal_embryonic_tissue0.68353276
134MP0005395_other_phenotype0.68214633
135MP0005501_abnormal_skin_physiology0.68045397
136MP0001216_abnormal_epidermal_layer0.67612374
137MP0000490_abnormal_crypts_of0.67381884
138MP0002019_abnormal_tumor_incidence0.67062628
139MP0001672_abnormal_embryogenesis/_devel0.65738616
140MP0005380_embryogenesis_phenotype0.65738616
141MP0005375_adipose_tissue_phenotype0.63809529
142MP0009703_decreased_birth_body0.63271852
143MP0010630_abnormal_cardiac_muscle0.61808372
144MP0009643_abnormal_urine_homeostasis0.61093444
145MP0008874_decreased_physiological_sensi0.60260375
146MP0003137_abnormal_impulse_conducting0.60034655
147MP0009333_abnormal_splenocyte_physiolog0.58654116
148MP0001915_intracranial_hemorrhage0.58526588
149MP0005220_abnormal_exocrine_pancreas0.57372711
150MP0008058_abnormal_DNA_repair0.56218598
151MP0002080_prenatal_lethality0.55302295

Predicted human phenotypes

RankGene SetZ-score
1Hypochromic microcytic anemia (HP:0004840)5.01610878
2Abnormality of aromatic amino acid family metabolism (HP:0004338)4.86397812
3Abnormality of cells of the erythroid lineage (HP:0012130)4.73027748
4Hypobetalipoproteinemia (HP:0003563)4.72824220
5Turricephaly (HP:0000262)4.69146525
6Concave nail (HP:0001598)4.62792212
7Pustule (HP:0200039)4.61429343
8Alopecia of scalp (HP:0002293)4.38644075
9Intrahepatic cholestasis (HP:0001406)4.37116918
10Microvesicular hepatic steatosis (HP:0001414)4.28744458
11Abnormal number of erythroid precursors (HP:0012131)4.28592055
12Facial hemangioma (HP:0000329)4.20841157
13Thrombocytosis (HP:0001894)4.08166437
14Deep venous thrombosis (HP:0002625)3.98414907
15Coronal craniosynostosis (HP:0004440)3.94522470
16Progressive muscle weakness (HP:0003323)3.93797751
17Rib fusion (HP:0000902)3.91518082
18Annular pancreas (HP:0001734)3.87317490
19Reticulocytopenia (HP:0001896)3.85607891
20Abnormal hemoglobin (HP:0011902)3.85001843
21Abnormality of monocarboxylic acid metabolism (HP:0010996)3.79146995
22Poikiloderma (HP:0001029)3.76114103
23Increased IgM level (HP:0003496)3.67301324
24Ulnar bowing (HP:0003031)3.53518785
25Rectovaginal fistula (HP:0000143)3.49155697
26Rectal fistula (HP:0100590)3.49155697
27Vaginal fistula (HP:0004320)3.38192665
28Xanthomatosis (HP:0000991)3.34612836
29Abnormality of reticulocytes (HP:0004312)3.32062730
30Abnormal gallbladder physiology (HP:0012438)3.25913162
31Cholecystitis (HP:0001082)3.25913162
32Acute lymphatic leukemia (HP:0006721)3.11780738
33Pallor (HP:0000980)3.11586058
34Hyperammonemia (HP:0001987)3.09923858
35Reticulocytosis (HP:0001923)3.06699233
36Intestinal fistula (HP:0100819)3.05430834
37Hypolipoproteinemia (HP:0010981)3.04922329
38Tongue fasciculations (HP:0001308)3.04376038
39Ketosis (HP:0001946)3.02994055
40Urinary glycosaminoglycan excretion (HP:0003541)3.00740071
41Mucopolysacchariduria (HP:0008155)3.00740071
42Prolonged partial thromboplastin time (HP:0003645)2.96777329
43Macrocytic anemia (HP:0001972)2.92113548
44Abnormality of male internal genitalia (HP:0000022)2.88032556
45Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.87687661
46Diaphragmatic weakness (HP:0009113)2.87020840
47Pancreatic islet-cell hyperplasia (HP:0004510)2.86915235
48Multiple enchondromatosis (HP:0005701)2.86861352
49Progressive external ophthalmoplegia (HP:0000590)2.86506799
50Ketoacidosis (HP:0001993)2.85346292
51Muscle fibrillation (HP:0010546)2.84894605
52Squamous cell carcinoma (HP:0002860)2.84195196
53Dysostosis multiplex (HP:0000943)2.80659300
54Growth hormone excess (HP:0000845)2.76745414
55Polycythemia (HP:0001901)2.76421154
56Birth length less than 3rd percentile (HP:0003561)2.72050921
57Chromosomal breakage induced by crosslinking agents (HP:0003221)2.71355661
58Chromsome breakage (HP:0040012)2.70891719
59Orthostatic hypotension (HP:0001278)2.69533540
60Abnormality of polysaccharide metabolism (HP:0011012)2.65337943
61Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65337943
62Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65337943
63Hyperlipoproteinemia (HP:0010980)2.63184769
64Lower limb hyperreflexia (HP:0002395)2.62410777
65Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.60395199
66Male infertility (HP:0003251)2.59990657
67Premature skin wrinkling (HP:0100678)2.59775247
68Hyperglycinemia (HP:0002154)2.59659909
69Short chin (HP:0000331)2.58713492
70Opisthotonus (HP:0002179)2.58694473
71Hypokinesia (HP:0002375)2.58095323
72Vertebral hypoplasia (HP:0008417)2.54989444
73Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.54989444
74Short humerus (HP:0005792)2.54266481
75Hyperglycinuria (HP:0003108)2.53087356
76Fat malabsorption (HP:0002630)2.52974131
77Anteriorly placed anus (HP:0001545)2.51860604
78Ragged-red muscle fibers (HP:0003200)2.49599795
79Myocardial infarction (HP:0001658)2.49161432
80Dysautonomia (HP:0002459)2.48978982
81Hypochromic anemia (HP:0001931)2.47564731
82Premature ovarian failure (HP:0008209)2.46848777
83Acute myeloid leukemia (HP:0004808)2.46040184
84Abnormality of sulfur amino acid metabolism (HP:0004339)2.44095681
85Abnormality of methionine metabolism (HP:0010901)2.43452819
86Abnormality of glutamine family amino acid metabolism (HP:0010902)2.40724588
87Abnormality of serine family amino acid metabolism (HP:0010894)2.39774955
88Abnormality of glycine metabolism (HP:0010895)2.39774955
89Seborrheic dermatitis (HP:0001051)2.37668039
90Truncus arteriosus (HP:0001660)2.36934201
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.36785917
92Myelodysplasia (HP:0002863)2.36755358
93Aplasia/hypoplasia of the humerus (HP:0006507)2.35648633
94Capillary hemangiomas (HP:0005306)2.33719770
95Clumsiness (HP:0002312)2.33669042
96Asymmetric septal hypertrophy (HP:0001670)2.33318885
97Hypertensive crisis (HP:0100735)2.32461242
98Rough bone trabeculation (HP:0100670)2.31537423
99Alacrima (HP:0000522)2.31191889
100Trismus (HP:0000211)2.30970515
101Deviation of the thumb (HP:0009603)2.30412196
102Malnutrition (HP:0004395)2.30296130
103Choanal stenosis (HP:0000452)2.29408798
104Spastic diplegia (HP:0001264)2.28687641
105Aplasia of the musculature (HP:0100854)2.26481502
106Broad distal phalanx of finger (HP:0009836)2.26334076
107Intestinal atresia (HP:0011100)2.26293283
108Proximal placement of thumb (HP:0009623)2.25722445
109Large for gestational age (HP:0001520)2.25295300
110Joint stiffness (HP:0001387)2.24359307
111Hypotrichosis (HP:0001006)2.23292854
112Abnormality of endocrine pancreas physiology (HP:0012093)2.23212412
113Abnormality of the pancreatic islet cells (HP:0006476)2.23212412
114Congenital hip dislocation (HP:0001374)2.23007237
115Basal cell carcinoma (HP:0002671)2.22147036
116Hypergonadotropic hypogonadism (HP:0000815)2.21921730
117Abnormality of homocysteine metabolism (HP:0010919)2.21313727
118Homocystinuria (HP:0002156)2.21313727
119Mesangial abnormality (HP:0001966)2.20800576
120Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19454019
121Steatorrhea (HP:0002570)2.17203319
122Urethral obstruction (HP:0000796)2.15147945
123Nephritis (HP:0000123)2.12223726
12411 pairs of ribs (HP:0000878)2.11308983
125Aplasia/Hypoplasia of the thymus (HP:0010515)2.10091997
126Abnormality of the lower motor neuron (HP:0002366)2.09759142
127Broad alveolar ridges (HP:0000187)2.09517671
128Type I transferrin isoform profile (HP:0003642)2.08356408
129Abnormality of glycolysis (HP:0004366)2.07447002
130Complement deficiency (HP:0004431)2.06934884
131Abnormality of pyrimidine metabolism (HP:0004353)2.06279615
132Absent radius (HP:0003974)2.05632868
133Abnormality of the heme biosynthetic pathway (HP:0010472)2.05510933
134Selective tooth agenesis (HP:0001592)2.05041439
135IgA deficiency (HP:0002720)2.04521085
136Hypoalphalipoproteinemia (HP:0003233)2.04270432
137Acute hepatic failure (HP:0006554)2.03545945
138Bowing of the arm (HP:0006488)1.97520553
139Bowed forearm bones (HP:0003956)1.97520553
140Exercise-induced myalgia (HP:0003738)1.96601473
141Abnormality of cochlea (HP:0000375)1.96597072
142Cholelithiasis (HP:0001081)1.96545062
143Thoracic kyphosis (HP:0002942)1.93316236
144Abnormality of the preputium (HP:0100587)1.90788489
145Hyperthyroidism (HP:0000836)1.90665298
146Abnormality of the thoracic spine (HP:0100711)1.90562187
147Breast hypoplasia (HP:0003187)1.90484555
148Aplastic anemia (HP:0001915)1.88643399
149Reduced antithrombin III activity (HP:0001976)1.83978607
150Colitis (HP:0002583)1.78885109
151Hyperacusis (HP:0010780)1.78059893
152Hypoparathyroidism (HP:0000829)1.76639260
153Increased serum pyruvate (HP:0003542)1.76204758
154Ankyloglossia (HP:0010296)1.75141727
155Pancytopenia (HP:0001876)1.73175293
156Overlapping toe (HP:0001845)1.72788981
157Flared metaphyses (HP:0003015)1.71727274
158Respiratory difficulties (HP:0002880)1.71356208
159Insomnia (HP:0100785)1.71125161
160Nonimmune hydrops fetalis (HP:0001790)1.71057690
161Abnormal protein glycosylation (HP:0012346)1.71035437
162Abnormal glycosylation (HP:0012345)1.71035437
163Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.71035437
164Abnormal protein N-linked glycosylation (HP:0012347)1.71035437
165Horseshoe kidney (HP:0000085)1.69675234
166Abnormal trabecular bone morphology (HP:0100671)1.67755573
167Short middle phalanx of the 5th finger (HP:0004220)1.67418029
168Achilles tendon contracture (HP:0001771)1.66986306
169Increased serum ferritin (HP:0003281)1.66520677
170Abnormality of the umbilical cord (HP:0010881)1.65531298
171Abnormality of the gallbladder (HP:0005264)1.65358413
172Hypoplasia of the capital femoral epiphysis (HP:0003090)1.64156129
173Abnormality of the fetal cardiovascular system (HP:0010948)1.63988816
174Abnormal umbilical cord blood vessels (HP:0011403)1.63988816
175Single umbilical artery (HP:0001195)1.63988816
176Atresia of the external auditory canal (HP:0000413)1.62281088
177Fatigue (HP:0012378)1.61763650
178Deep palmar crease (HP:0006191)1.61375708
179Testicular atrophy (HP:0000029)1.61212144
180Secondary amenorrhea (HP:0000869)1.61062472
181Abnormal platelet function (HP:0011869)1.59906289
182Impaired platelet aggregation (HP:0003540)1.59906289
183Neoplasm of the pancreas (HP:0002894)1.58769632
184Polygenic inheritance (HP:0010982)1.58604841
185Abnormal large intestine physiology (HP:0012700)1.58597948
186Increased nuchal translucency (HP:0010880)1.58246870
187Microretrognathia (HP:0000308)1.57343485
188Villous atrophy (HP:0011473)1.57255973
189Abnormality of small intestinal villus morphology (HP:0011472)1.57255973
190Agammaglobulinemia (HP:0004432)1.56225263
191Abnormal gallbladder morphology (HP:0012437)1.55978737
192Missing ribs (HP:0000921)1.54887920
193Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.54574337
194Obstructive lung disease (HP:0006536)1.54096229

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.96490518
2MAP3K65.21946486
3MAPK154.87977373
4DDR24.80832779
5MAP3K113.95451007
6SMG13.65538305
7PINK13.48561106
8EEF2K3.22422478
9VRK23.00051492
10BUB12.94518736
11TYRO32.88033237
12CDC72.83570148
13FGR2.82303550
14MATK2.77656842
15CDK122.73795673
16DAPK12.48434577
17BMX2.42260983
18PIM22.37138850
19IRAK32.21046091
20CSK2.17636611
21UHMK12.16141661
22SRPK12.04591711
23PDGFRA1.92754868
24PRKD21.84580829
25BCKDK1.80179001
26DYRK1B1.79146260
27SCYL21.76540723
28YES11.70883737
29TRPM71.58773383
30NME11.51676993
31LATS21.47423952
32CDK71.46263223
33EIF2AK11.44160001
34RPS6KA41.39789608
35GSK3A1.29234059
36CDK61.25975519
37PIM11.25109947
38MAP3K81.24854532
39PLK41.24800210
40MAPK111.22601295
41PBK1.20710565
42STK161.19017967
43PASK1.18292681
44PHKG21.16981065
45PHKG11.16981065
46AKT31.12923757
47RPS6KL11.09634193
48RPS6KC11.09634193
49CHEK11.09098735
50NME21.02972461
51RIPK41.02285257
52RPS6KA60.99829045
53TSSK60.97773199
54AURKB0.96023323
55TRIB30.95999409
56TAOK20.95721276
57MKNK10.92869477
58KDR0.91576304
59NEK20.89497848
60LRRK20.84272248
61STK40.82626675
62IRAK20.82625961
63CDC42BPA0.82177819
64PKN20.81220160
65CDK80.80445289
66SIK10.78450442
67VRK10.78320436
68CHEK20.74943158
69BRD40.70002659
70MAP4K10.69742658
71DYRK30.68682316
72MTOR0.67871729
73TAF10.67698699
74BRAF0.67301850
75EPHA20.67273502
76ALK0.66623443
77MAPK40.66117650
78CCNB10.66034735
79CAMK2G0.64001745
80STK100.63958848
81CDK90.63425169
82CDK10.62033192
83PRKAA10.61062025
84EGFR0.60341973
85WEE10.59228445
86RAF10.59123029
87ARAF0.58917767
88MAP2K20.58651526
89ATM0.57850308
90MAP3K100.57058234
91ILK0.57046785
92CAMK2B0.56925277
93BRSK10.56321074
94CSNK1G10.55687324
95PLK10.55066701
96MAP2K30.54898362
97PLK30.53116791
98MST1R0.51633307
99PRPF4B0.50323134
100FGFR40.48038458
101RPS6KA10.47933263
102PRKD30.45707773
103EIF2AK20.45560683
104RPS6KB10.44734583
105PTK60.44676300
106CDK190.42928950
107HIPK20.42697815
108PAK10.42396004
109ERN10.41369038
110TNK20.41298733
111CSNK2A10.40776334
112RPS6KB20.40755749
113IRAK40.40629202
114MAP3K10.38722496
115CDK30.38545518
116NUAK10.37675217
117BTK0.37398505
118LYN0.37118136
119PAK20.37089979
120PRKCZ0.35944270
121MKNK20.35833887
122PRKAA20.35569748
123CSNK2A20.34838030
124MAPK30.34387554
125ATR0.34139217
126TAOK10.34103322
127TESK20.34081786
128AURKA0.33857656
129MAP3K30.33135226
130FLT30.32555984
131CDK20.31439622
132MAP3K90.31393823
133MAPKAPK30.30354392
134PDGFRB0.28171484
135STK30.28036586
136CAMK2A0.27118778
137MAPK10.27113903
138DYRK20.25887170
139PRKACG0.24657856
140INSR0.23846896
141NEK10.23642985
142MAPK100.22584808
143CDK11A0.21279923
144FGFR10.20665216
145CAMK2D0.20532263
146CDK150.20106188
147JAK20.18682173
148CLK10.17771301
149PRKD10.17076491
150PAK40.16883552
151CDK180.15154777
152TTK0.15012805
153GRK60.14402670
154PRKCD0.13955300
155ABL20.13912628
156CDK40.13581155
157MAPK140.13263817
158LCK0.13063454
159OXSR10.12840291
160ERBB40.12793856

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.92699546
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.41124997
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.01170147
4Arginine biosynthesis_Homo sapiens_hsa002202.96297006
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.73764589
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.72831367
7Mismatch repair_Homo sapiens_hsa034302.56233806
8Pentose and glucuronate interconversions_Homo sapiens_hsa000402.47835187
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.47447122
10Base excision repair_Homo sapiens_hsa034102.44735216
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.41693835
12Fatty acid metabolism_Homo sapiens_hsa012122.40410647
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.37262132
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.30241865
15Arginine and proline metabolism_Homo sapiens_hsa003302.26353075
16Biosynthesis of amino acids_Homo sapiens_hsa012302.18128625
17Cell cycle_Homo sapiens_hsa041102.12377699
18RNA polymerase_Homo sapiens_hsa030202.05266766
19Pyrimidine metabolism_Homo sapiens_hsa002402.04093010
20Nitrogen metabolism_Homo sapiens_hsa009102.01885490
21Folate biosynthesis_Homo sapiens_hsa007901.98671381
22Sulfur relay system_Homo sapiens_hsa041221.89262084
23Non-homologous end-joining_Homo sapiens_hsa034501.88379969
24DNA replication_Homo sapiens_hsa030301.86189439
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81215236
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76330560
27Proteasome_Homo sapiens_hsa030501.74106686
28Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.73350535
29Tryptophan metabolism_Homo sapiens_hsa003801.72780153
30Other glycan degradation_Homo sapiens_hsa005111.59655245
31Propanoate metabolism_Homo sapiens_hsa006401.58383223
32Fatty acid degradation_Homo sapiens_hsa000711.58066104
33Fatty acid elongation_Homo sapiens_hsa000621.56267168
34Butanoate metabolism_Homo sapiens_hsa006501.54592604
35Complement and coagulation cascades_Homo sapiens_hsa046101.54097718
36Peroxisome_Homo sapiens_hsa041461.47950290
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.44474165
38Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.41968479
39Cysteine and methionine metabolism_Homo sapiens_hsa002701.35476400
40Acute myeloid leukemia_Homo sapiens_hsa052211.34347889
41Steroid biosynthesis_Homo sapiens_hsa001001.33868739
42Pyruvate metabolism_Homo sapiens_hsa006201.28681361
43Drug metabolism - other enzymes_Homo sapiens_hsa009831.24998848
44Lysine degradation_Homo sapiens_hsa003101.23160683
45Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.20612829
46beta-Alanine metabolism_Homo sapiens_hsa004101.19210442
47Chronic myeloid leukemia_Homo sapiens_hsa052201.18276733
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14205558
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13971835
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.13712632
51Chemical carcinogenesis_Homo sapiens_hsa052041.12068965
52PPAR signaling pathway_Homo sapiens_hsa033201.10863608
53Carbon metabolism_Homo sapiens_hsa012001.09276850
54One carbon pool by folate_Homo sapiens_hsa006701.07900915
55Selenocompound metabolism_Homo sapiens_hsa004501.06950483
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.06759995
57Thyroid cancer_Homo sapiens_hsa052161.06327158
58Purine metabolism_Homo sapiens_hsa002301.06053911
59N-Glycan biosynthesis_Homo sapiens_hsa005101.06028666
60Histidine metabolism_Homo sapiens_hsa003401.04289314
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.02997414
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.02526388
63Glutathione metabolism_Homo sapiens_hsa004801.02357102
64Starch and sucrose metabolism_Homo sapiens_hsa005000.99589503
65Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.97726451
66RNA degradation_Homo sapiens_hsa030180.96332756
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.94739205
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92559718
69Nucleotide excision repair_Homo sapiens_hsa034200.91880567
70Steroid hormone biosynthesis_Homo sapiens_hsa001400.90784594
71Circadian rhythm_Homo sapiens_hsa047100.90492783
72Bile secretion_Homo sapiens_hsa049760.89994941
73Fructose and mannose metabolism_Homo sapiens_hsa000510.89354881
74Non-small cell lung cancer_Homo sapiens_hsa052230.88011189
75Basal transcription factors_Homo sapiens_hsa030220.87305165
76Epstein-Barr virus infection_Homo sapiens_hsa051690.86955545
77Retinol metabolism_Homo sapiens_hsa008300.86652095
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85106239
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.81374972
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80978274
81Fat digestion and absorption_Homo sapiens_hsa049750.80370925
82Phenylalanine metabolism_Homo sapiens_hsa003600.80270226
83Pancreatic cancer_Homo sapiens_hsa052120.79895054
84mTOR signaling pathway_Homo sapiens_hsa041500.79687914
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.76010367
86Sulfur metabolism_Homo sapiens_hsa009200.71606554
87Herpes simplex infection_Homo sapiens_hsa051680.71571029
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70164643
89Tyrosine metabolism_Homo sapiens_hsa003500.69251043
90ABC transporters_Homo sapiens_hsa020100.68749454
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.67713726
92Staphylococcus aureus infection_Homo sapiens_hsa051500.67596837
93Viral carcinogenesis_Homo sapiens_hsa052030.65740372
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65091705
95Bladder cancer_Homo sapiens_hsa052190.64175901
96Glycerolipid metabolism_Homo sapiens_hsa005610.62831587
97HTLV-I infection_Homo sapiens_hsa051660.61870940
98Galactose metabolism_Homo sapiens_hsa000520.61480843
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58286706
100Hedgehog signaling pathway_Homo sapiens_hsa043400.56761147
101Huntingtons disease_Homo sapiens_hsa050160.55363336
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54203838
103Homologous recombination_Homo sapiens_hsa034400.53387000
104RNA transport_Homo sapiens_hsa030130.52797849
105Colorectal cancer_Homo sapiens_hsa052100.52382856
106Hippo signaling pathway_Homo sapiens_hsa043900.51494645
107B cell receptor signaling pathway_Homo sapiens_hsa046620.51423787
108Metabolic pathways_Homo sapiens_hsa011000.51330694
109MicroRNAs in cancer_Homo sapiens_hsa052060.50049688
110Notch signaling pathway_Homo sapiens_hsa043300.48933558
111Hepatitis B_Homo sapiens_hsa051610.48136762
112Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47630843
113p53 signaling pathway_Homo sapiens_hsa041150.45320152
114Small cell lung cancer_Homo sapiens_hsa052220.44923810
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44181417
116Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.43884971
117Spliceosome_Homo sapiens_hsa030400.43495565
118Parkinsons disease_Homo sapiens_hsa050120.43456969
119Vitamin B6 metabolism_Homo sapiens_hsa007500.43044204
120Apoptosis_Homo sapiens_hsa042100.41992896
121Caffeine metabolism_Homo sapiens_hsa002320.41816920
122Pentose phosphate pathway_Homo sapiens_hsa000300.41231513
123Fanconi anemia pathway_Homo sapiens_hsa034600.40769759
124Prostate cancer_Homo sapiens_hsa052150.39781320
125Adherens junction_Homo sapiens_hsa045200.35958163
126mRNA surveillance pathway_Homo sapiens_hsa030150.34650403
127Endometrial cancer_Homo sapiens_hsa052130.33000734
128TGF-beta signaling pathway_Homo sapiens_hsa043500.31849784
129VEGF signaling pathway_Homo sapiens_hsa043700.29443869
130Renal cell carcinoma_Homo sapiens_hsa052110.27851158
131HIF-1 signaling pathway_Homo sapiens_hsa040660.27703699
132Oocyte meiosis_Homo sapiens_hsa041140.27395048
133AMPK signaling pathway_Homo sapiens_hsa041520.26922233
134Vitamin digestion and absorption_Homo sapiens_hsa049770.25806970
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.25783790
136Protein export_Homo sapiens_hsa030600.25016696
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.24722516
138Oxidative phosphorylation_Homo sapiens_hsa001900.24694084
139Influenza A_Homo sapiens_hsa051640.22178311
140Shigellosis_Homo sapiens_hsa051310.22153404
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22033972
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21868284
143Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21446962
144Ribosome_Homo sapiens_hsa030100.19995376
145Systemic lupus erythematosus_Homo sapiens_hsa053220.18869829
146Insulin signaling pathway_Homo sapiens_hsa049100.13551963
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11104767
148Transcriptional misregulation in cancer_Homo sapiens_hsa052020.10805450

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