TONSL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.87963377
2DNA deamination (GO:0045006)7.54230687
3transcription from mitochondrial promoter (GO:0006390)7.15669841
4proline metabolic process (GO:0006560)6.39322019
5DNA unwinding involved in DNA replication (GO:0006268)6.00273550
6positive regulation of protein homooligomerization (GO:0032464)5.73569156
7viral mRNA export from host cell nucleus (GO:0046784)5.69254221
8embryonic process involved in female pregnancy (GO:0060136)5.46008013
9DNA replication checkpoint (GO:0000076)5.20777346
10DNA replication initiation (GO:0006270)5.16078637
11oxidative demethylation (GO:0070989)5.07183470
12formation of translation preinitiation complex (GO:0001731)5.04450597
13telomere maintenance via semi-conservative replication (GO:0032201)4.94833458
14* replication fork processing (GO:0031297)4.90599900
15regulation of protein homooligomerization (GO:0032462)4.87250128
16GDP-mannose metabolic process (GO:0019673)4.69340828
17somatic hypermutation of immunoglobulin genes (GO:0016446)4.64827168
18somatic diversification of immune receptors via somatic mutation (GO:0002566)4.64827168
19cellular response to zinc ion (GO:0071294)4.62364808
20mitotic sister chromatid segregation (GO:0000070)4.58607953
21DNA strand renaturation (GO:0000733)4.57610346
22mitotic chromosome condensation (GO:0007076)4.46092110
23regulation of integrin activation (GO:0033623)4.34496433
24heterochromatin organization (GO:0070828)4.34434421
25pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.26446584
26* maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.20807385
27cullin deneddylation (GO:0010388)4.18713421
28base-excision repair (GO:0006284)4.18384029
29nucleotide-excision repair, DNA gap filling (GO:0006297)4.18013584
30telomere maintenance via recombination (GO:0000722)4.14442894
31mitochondrial DNA metabolic process (GO:0032042)4.13571682
32poly(A)+ mRNA export from nucleus (GO:0016973)4.13506883
33sister chromatid segregation (GO:0000819)4.12133691
34base-excision repair, AP site formation (GO:0006285)4.11542607
35DNA duplex unwinding (GO:0032508)4.01326648
36DNA strand elongation involved in DNA replication (GO:0006271)3.99367756
37protein deneddylation (GO:0000338)3.99092318
38establishment of protein localization to mitochondrial membrane (GO:0090151)3.91785097
39DNA integration (GO:0015074)3.87351379
40DNA geometric change (GO:0032392)3.86569941
41DNA strand elongation (GO:0022616)3.82969204
42establishment of apical/basal cell polarity (GO:0035089)3.82900885
43DNA double-strand break processing (GO:0000729)3.82107911
44mitochondrial RNA metabolic process (GO:0000959)3.80461831
45negative regulation of JAK-STAT cascade (GO:0046426)3.79474389
46nuclear pore complex assembly (GO:0051292)3.78444499
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76441998
48positive regulation of developmental pigmentation (GO:0048087)3.73676448
49regulation of translational fidelity (GO:0006450)3.64821982
50pyrimidine nucleotide catabolic process (GO:0006244)3.62353968
51regulation of nuclear cell cycle DNA replication (GO:0033262)3.59615148
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.59450547
53mRNA cleavage (GO:0006379)3.59439017
54maturation of 5.8S rRNA (GO:0000460)3.57396731
55chromatin assembly (GO:0031497)3.57049487
56L-serine metabolic process (GO:0006563)3.50781782
57establishment of monopolar cell polarity (GO:0061162)3.50139489
58establishment or maintenance of monopolar cell polarity (GO:0061339)3.50139489
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.46817460
60protein localization to chromosome, centromeric region (GO:0071459)3.46586307
61dosage compensation (GO:0007549)3.46243046
62telomere maintenance via telomere lengthening (GO:0010833)3.45913654
63cellular response to ATP (GO:0071318)3.45432849
64mitotic recombination (GO:0006312)3.45055713
65peptidyl-arginine omega-N-methylation (GO:0035247)3.44945445
66nuclear pore organization (GO:0006999)3.44880406
67mitotic G1 DNA damage checkpoint (GO:0031571)3.44867405
68folic acid metabolic process (GO:0046655)3.43849212
69DNA replication-dependent nucleosome assembly (GO:0006335)3.43034649
70DNA replication-dependent nucleosome organization (GO:0034723)3.43034649
71DNA conformation change (GO:0071103)3.41182861
72folic acid-containing compound biosynthetic process (GO:0009396)3.39612204
73oxidative phosphorylation (GO:0006119)3.36604954
74regulation of double-strand break repair via homologous recombination (GO:0010569)3.36495203
75proteasome assembly (GO:0043248)3.30860926
76protein-DNA complex disassembly (GO:0032986)3.30527232
77nucleosome disassembly (GO:0006337)3.30527232
78double-strand break repair via nonhomologous end joining (GO:0006303)3.28307299
79non-recombinational repair (GO:0000726)3.28307299
80ribosomal small subunit biogenesis (GO:0042274)3.26589779
81negative regulation of cell cycle arrest (GO:0071157)3.24837344
82negative regulation of mRNA metabolic process (GO:1903312)3.22874017
83DNA demethylation (GO:0080111)3.19770780
84spliceosomal tri-snRNP complex assembly (GO:0000244)3.19398435
85negative regulation of protein oligomerization (GO:0032460)3.17936508
86protein localization to kinetochore (GO:0034501)3.17843946
87termination of RNA polymerase II transcription (GO:0006369)3.17683615
88chromosome condensation (GO:0030261)3.16642644
89DNA synthesis involved in DNA repair (GO:0000731)3.13188653
90rRNA transcription (GO:0009303)3.12812553
91mitotic nuclear envelope disassembly (GO:0007077)3.12570422
92positive regulation of DNA repair (GO:0045739)3.12529319
93nucleobase biosynthetic process (GO:0046112)3.11717420
94regulation of centrosome cycle (GO:0046605)3.07071782
95regulation of mitochondrial depolarization (GO:0051900)3.06525395
96positive regulation of DNA-dependent DNA replication (GO:2000105)3.05472618
97maturation of SSU-rRNA (GO:0030490)3.05078482
98negative regulation of heart rate (GO:0010459)3.03042076
99ribosomal small subunit assembly (GO:0000028)3.01500126
100positive regulation of protein oligomerization (GO:0032461)3.00560662
101DNA replication (GO:0006260)3.00462634
102chromatin assembly or disassembly (GO:0006333)3.00231538
103ncRNA 3-end processing (GO:0043628)3.00058774
104meiotic chromosome segregation (GO:0045132)2.98990178
105translesion synthesis (GO:0019985)2.98489860
106DNA ligation (GO:0006266)2.98155259
107DNA damage induced protein phosphorylation (GO:0006975)2.95026129
108pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.94285775
109mitotic sister chromatid cohesion (GO:0007064)2.94079848
110regulation of mammary gland epithelial cell proliferation (GO:0033599)2.94012608
111tRNA modification (GO:0006400)2.93837682
112pseudouridine synthesis (GO:0001522)2.93661712
113mitotic G1/S transition checkpoint (GO:0044819)2.91881984
114regulation of protein oligomerization (GO:0032459)2.89684434
115positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.89031019
116negative regulation of RNA splicing (GO:0033119)2.88736093
117pore complex assembly (GO:0046931)2.88675972
118positive regulation of lamellipodium assembly (GO:0010592)2.87115560
119regulation of DNA-dependent DNA replication (GO:0090329)2.84809481
120positive regulation of chromosome segregation (GO:0051984)2.84461562
121ribonucleoprotein complex biogenesis (GO:0022613)2.83530654
122negative regulation of mRNA processing (GO:0050686)2.83170141
123snRNA metabolic process (GO:0016073)2.82219229
124glutamine family amino acid biosynthetic process (GO:0009084)2.81383276
125pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.81221564
126membrane disassembly (GO:0030397)2.79931263
127nuclear envelope disassembly (GO:0051081)2.79931263
128kinetochore assembly (GO:0051382)2.79508703
129tRNA methylation (GO:0030488)2.79393444
130membrane invagination (GO:0010324)2.76572666
131regulation of centrosome duplication (GO:0010824)2.76379833
132histone H4-K12 acetylation (GO:0043983)2.75858707
133peptidyl-arginine N-methylation (GO:0035246)2.75598664
134peptidyl-arginine methylation (GO:0018216)2.75598664
135G1 DNA damage checkpoint (GO:0044783)2.74793983
136serine family amino acid biosynthetic process (GO:0009070)2.74169775
137ribosome biogenesis (GO:0042254)2.72634939
138DNA packaging (GO:0006323)2.72082797
139activation of Rac GTPase activity (GO:0032863)2.71912492
140regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.71379317
141apoptotic process involved in morphogenesis (GO:0060561)2.71144999
142histone arginine methylation (GO:0034969)2.70649582
143convergent extension (GO:0060026)2.70080852
144telomere organization (GO:0032200)2.69960552
145deoxyribonucleotide catabolic process (GO:0009264)2.69812916
146telomere maintenance (GO:0000723)2.69659956
147positive regulation by host of viral transcription (GO:0043923)2.69286808
148transcription-coupled nucleotide-excision repair (GO:0006283)2.68894201
149regulation of double-strand break repair (GO:2000779)2.68659939
150sequestering of actin monomers (GO:0042989)2.67747953
151regulation of translational termination (GO:0006449)2.67696476
152chromosome segregation (GO:0007059)2.66886199
153protein neddylation (GO:0045116)2.66632230
154pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.66464389
155mitochondrial DNA replication (GO:0006264)2.65647683
156regulation of histone H3-K4 methylation (GO:0051569)2.65050102
157histone phosphorylation (GO:0016572)2.64330010
158DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.62376492
159inner cell mass cell proliferation (GO:0001833)2.62120640
160protein complex localization (GO:0031503)2.61904414
161negative regulation of tumor necrosis factor production (GO:0032720)2.61522959
162DNA dealkylation (GO:0035510)2.61336670
163embryonic placenta development (GO:0001892)2.60054306
164signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.56922798
165intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.56922798
166regulation of DNA damage checkpoint (GO:2000001)2.56469679
167spliceosomal snRNP assembly (GO:0000387)2.56168039
168DNA topological change (GO:0006265)2.55282628
169mitotic nuclear envelope reassembly (GO:0007084)2.54678884
170nuclear envelope reassembly (GO:0031468)2.54678884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.16660772
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56250108
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.18054131
4E2F7_22180533_ChIP-Seq_HELA_Human3.13539661
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.90885982
6MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67522524
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.50156076
8VDR_21846776_ChIP-Seq_THP-1_Human2.31881390
9ETS1_20019798_ChIP-Seq_JURKAT_Human2.31160568
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.30521443
11THAP11_20581084_ChIP-Seq_MESCs_Mouse2.30124392
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28209238
13YY1_21170310_ChIP-Seq_MESCs_Mouse2.19965965
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17932616
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15046197
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14119830
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.13457206
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.10299512
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.09223731
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.08882812
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.06304210
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.95377607
23* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.92987274
24PU.1_20513432_ChIP-Seq_Bcells_Mouse1.89618943
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86227486
26MYC_22102868_ChIP-Seq_BL_Human1.85992962
27GABP_19822575_ChIP-Seq_HepG2_Human1.84692988
28DCP1A_22483619_ChIP-Seq_HELA_Human1.82248034
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.81131286
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.75783523
31VDR_23849224_ChIP-Seq_CD4+_Human1.74071890
32KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.73615153
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.73017438
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.71663317
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.71356540
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.70584037
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67150820
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65210682
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.63225694
40XRN2_22483619_ChIP-Seq_HELA_Human1.62327461
41P68_20966046_ChIP-Seq_HELA_Human1.61902645
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61384051
43STAT3_1855785_ChIP-Seq_MESCs_Mouse1.60666998
44RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58981748
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56829367
46ZNF263_19887448_ChIP-Seq_K562_Human1.56809236
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56275289
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.56244714
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.50669661
50CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50650708
51KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.50565725
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.50565725
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.50565725
54NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50435135
55BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.50016968
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.49306344
57PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.48522122
58DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.47057364
59POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.46020732
60LXR_22292898_ChIP-Seq_THP-1_Human1.45601853
61NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.44510945
62CIITA_25753668_ChIP-Seq_RAJI_Human1.43713270
63NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.43695717
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.42544240
65FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.41030250
66RACK7_27058665_Chip-Seq_MCF-7_Human1.40709461
67E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.38494797
68FOXP3_21729870_ChIP-Seq_TREG_Human1.37794160
69CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37714926
70KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37045315
71TTF2_22483619_ChIP-Seq_HELA_Human1.36876493
72SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36106315
73NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.34867700
74SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.34807959
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.31992105
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.31113583
77SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.30873020
78CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.30124376
79ESR1_15608294_ChIP-ChIP_MCF-7_Human1.29896659
80TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29201139
81E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28305483
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28183310
83FOXP1_21924763_ChIP-Seq_HESCs_Human1.27723662
84KDM5A_27292631_Chip-Seq_BREAST_Human1.26901630
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.26346036
86ELK3_25401928_ChIP-Seq_HUVEC_Human1.26097264
87SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25478858
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23836089
89SPI1_23547873_ChIP-Seq_NB4_Human1.23364270
90ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23349612
91MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23151158
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.22286121
93YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20367608
94NANOG_21062744_ChIP-ChIP_HESCs_Human1.19900020
95AR_21909140_ChIP-Seq_LNCAP_Human1.19800260
96BCL6_27268052_Chip-Seq_Bcells_Human1.18774201
97ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18756400
98SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.18115302
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17846434
100KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16527867
101HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15518248
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15152301
103MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14584917
104ETS1_21867929_ChIP-Seq_TH2_Mouse1.14039012
105IRF8_21731497_ChIP-ChIP_J774_Mouse1.13709975
106IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.13422837
107CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13112088
108KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12821340
109TFEB_21752829_ChIP-Seq_HELA_Human1.12685930
110ELF1_20517297_ChIP-Seq_JURKAT_Human1.11626023
111POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11427007
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09981700
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.09875860
114RARA_24833708_ChIP-Seq_LIVER_Mouse1.08963824
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.08919759
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.08875527
117KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07333914
118ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06608312
119MAF_26560356_Chip-Seq_TH1_Human1.06340067
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05682761
121MAF_26560356_Chip-Seq_TH2_Human1.05597857
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05504816
123CTCF_26484167_Chip-Seq_Bcells_Mouse1.04510632
124PHF8_20622854_ChIP-Seq_HELA_Human1.04343447
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04268401
126TP53_22127205_ChIP-Seq_IMR90_Human1.03914571
127YY1_22570637_ChIP-Seq_MALME-3M_Human1.03789512
128VDR_24763502_ChIP-Seq_THP-1_Human1.03254870
129CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.02727894
130CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02512046
131SMC4_20622854_ChIP-Seq_HELA_Human1.02374043
132NCOR1_26117541_ChIP-Seq_K562_Human1.01701441
133CREB1_26743006_Chip-Seq_LNCaP_Human1.01549661
134OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01066689
135MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00437735
136RARB_24833708_ChIP-Seq_LIVER_Mouse1.00059228
137SA1_27219007_Chip-Seq_ERYTHROID_Human0.99211242
138KDM2B_26808549_Chip-Seq_DND41_Human0.98833498
139TBX5_21415370_ChIP-Seq_HL-1_Mouse0.98547216
140CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98240978
141HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98176254
142PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97877854
143E2F1_20622854_ChIP-Seq_HELA_Human0.97859177
144STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96732229
145KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94078587
146BCOR_27268052_Chip-Seq_Bcells_Human0.93950682

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.84036227
2MP0009278_abnormal_bone_marrow3.59708039
3MP0005171_absent_coat_pigmentation3.31685445
4MP0005397_hematopoietic_system_phenotyp2.75936565
5MP0001545_abnormal_hematopoietic_system2.75936565
6MP0010094_abnormal_chromosome_stability2.69769904
7MP0005174_abnormal_tail_pigmentation2.59536917
8MP0005076_abnormal_cell_differentiation2.45203777
9MP0008058_abnormal_DNA_repair2.39426507
10MP0004957_abnormal_blastocyst_morpholog2.36421375
11MP0002009_preneoplasia2.34976135
12MP0003786_premature_aging2.34682326
13MP0000490_abnormal_crypts_of2.29311735
14MP0004233_abnormal_muscle_weight2.28253155
15MP0008995_early_reproductive_senescence2.26738550
16MP0003705_abnormal_hypodermis_morpholog2.23432448
17MP0000566_synostosis2.23315950
18MP0005075_abnormal_melanosome_morpholog2.18409644
19MP0000685_abnormal_immune_system2.15502957
20MP0010030_abnormal_orbit_morphology2.14612891
21MP0000015_abnormal_ear_pigmentation2.11881715
22MP0009333_abnormal_splenocyte_physiolog2.11836036
23MP0003763_abnormal_thymus_physiology2.04612130
24MP0008877_abnormal_DNA_methylation1.95120717
25MP0003172_abnormal_lysosome_physiology1.90643149
26MP0003693_abnormal_embryo_hatching1.88502234
27MP0001835_abnormal_antigen_presentation1.85770221
28MP0000537_abnormal_urethra_morphology1.85311196
29MP0002405_respiratory_system_inflammati1.81540385
30MP0005058_abnormal_lysosome_morphology1.81197085
31MP0002396_abnormal_hematopoietic_system1.81103200
32MP0005671_abnormal_response_to1.79511081
33MP0003111_abnormal_nucleus_morphology1.68979645
34MP0003077_abnormal_cell_cycle1.66916903
35MP0005380_embryogenesis_phenotype1.64489408
36MP0001672_abnormal_embryogenesis/_devel1.64489408
37MP0002398_abnormal_bone_marrow1.64307339
38MP0002653_abnormal_ependyma_morphology1.63055287
39MP0003866_abnormal_defecation1.61511864
40MP0000689_abnormal_spleen_morphology1.59346536
41MP0001346_abnormal_lacrimal_gland1.57515436
42MP0000371_diluted_coat_color1.57139010
43MP0009785_altered_susceptibility_to1.55335267
44MP0004185_abnormal_adipocyte_glucose1.54820882
45MP0002085_abnormal_embryonic_tissue1.54603552
46MP0009672_abnormal_birth_weight1.53340163
47MP0010155_abnormal_intestine_physiology1.52631157
48MP0006082_CNS_inflammation1.51839470
49MP0008932_abnormal_embryonic_tissue1.51610501
50MP0002019_abnormal_tumor_incidence1.49527055
51MP0003984_embryonic_growth_retardation1.47114726
52MP0002166_altered_tumor_susceptibility1.46154243
53MP0003123_paternal_imprinting1.46052175
54MP0003315_abnormal_perineum_morphology1.43834675
55MP0006072_abnormal_retinal_apoptosis1.43169725
56MP0010307_abnormal_tumor_latency1.41985237
57MP0004133_heterotaxia1.41236969
58MP0003136_yellow_coat_color1.40216361
59MP0003283_abnormal_digestive_organ1.39525739
60MP0002088_abnormal_embryonic_growth/wei1.39389459
61MP0004197_abnormal_fetal_growth/weight/1.38959544
62MP0005645_abnormal_hypothalamus_physiol1.38375707
63MP0002722_abnormal_immune_system1.36856272
64MP0002148_abnormal_hypersensitivity_rea1.36270372
65MP0002877_abnormal_melanocyte_morpholog1.34581420
66MP0003656_abnormal_erythrocyte_physiolo1.33802263
67MP0005025_abnormal_response_to1.32056370
68MP0002249_abnormal_larynx_morphology1.31031876
69MP0003937_abnormal_limbs/digits/tail_de1.30203355
70MP0005501_abnormal_skin_physiology1.30137368
71MP0001873_stomach_inflammation1.30063916
72MP0003890_abnormal_embryonic-extraembry1.28451763
73MP0001800_abnormal_humoral_immune1.28342391
74MP0002006_tumorigenesis1.27221134
75MP0000716_abnormal_immune_system1.26775634
76MP0002420_abnormal_adaptive_immunity1.24227082
77MP0002132_abnormal_respiratory_system1.23724117
78MP0002429_abnormal_blood_cell1.23483055
79MP0001819_abnormal_immune_cell1.23150467
80MP0002089_abnormal_postnatal_growth/wei1.21339122
81MP0005464_abnormal_platelet_physiology1.21148094
82MP0002210_abnormal_sex_determination1.19594987
83MP0001348_abnormal_lacrimal_gland1.19379245
84MP0001849_ear_inflammation1.16901987
85MP0002697_abnormal_eye_size1.15783889
86MP0002111_abnormal_tail_morphology1.15572526
87MP0002723_abnormal_immune_serum1.14788140
88MP0000703_abnormal_thymus_morphology1.13505894
89MP0000003_abnormal_adipose_tissue1.12927405
90MP0002452_abnormal_antigen_presenting1.12525575
91MP0000313_abnormal_cell_death1.11324209
92MP0003942_abnormal_urinary_system1.09880334
93MP0000470_abnormal_stomach_morphology1.09100901
94MP0001661_extended_life_span1.05963719
95MP0000678_abnormal_parathyroid_gland1.05040672
96MP0003718_maternal_effect1.04839602
97MP0002938_white_spotting1.04760166
98MP0005083_abnormal_biliary_tract1.04554601
99MP0005000_abnormal_immune_tolerance1.03522147
100MP0001697_abnormal_embryo_size1.02703060
101MP0000639_abnormal_adrenal_gland1.02397139
102MP0002160_abnormal_reproductive_system1.01745695
103MP0004858_abnormal_nervous_system1.01532244
104MP0003436_decreased_susceptibility_to1.01382678
105MP0002086_abnormal_extraembryonic_tissu1.01058092
106MP0003861_abnormal_nervous_system1.01020582
107MP0000358_abnormal_cell_content/0.99426616
108MP0004264_abnormal_extraembryonic_tissu0.98979752
109MP0002075_abnormal_coat/hair_pigmentati0.96882512
110MP0001186_pigmentation_phenotype0.93444007
111MP0000350_abnormal_cell_proliferation0.92658044
112MP0003453_abnormal_keratinocyte_physiol0.92122807
113MP0009053_abnormal_anal_canal0.91294054
114MP0003943_abnormal_hepatobiliary_system0.90966457
115MP0001286_abnormal_eye_development0.89525391
116MP0000579_abnormal_nail_morphology0.89401108
117MP0002092_abnormal_eye_morphology0.89303872
118MP0001145_abnormal_male_reproductive0.88824939
119MP0000428_abnormal_craniofacial_morphol0.88795020
120MP0003115_abnormal_respiratory_system0.88654303
121MP0000477_abnormal_intestine_morphology0.88000452
122MP0005387_immune_system_phenotype0.87873582
123MP0001790_abnormal_immune_system0.87873582
124MP0004142_abnormal_muscle_tone0.87541799
125MP0006035_abnormal_mitochondrial_morpho0.85755594
126MP0002163_abnormal_gland_morphology0.85031529
127MP0004808_abnormal_hematopoietic_stem0.84643393
128MP0008007_abnormal_cellular_replicative0.84114615
129MP0002751_abnormal_autonomic_nervous0.83407652
130MP0002098_abnormal_vibrissa_morphology0.83068642
131MP0001845_abnormal_inflammatory_respons0.82955281
132MP0005266_abnormal_metabolism0.81897935
133MP0004381_abnormal_hair_follicle0.81549078
134MP0001188_hyperpigmentation0.80408809
135MP0001986_abnormal_taste_sensitivity0.79790376
136MP0009697_abnormal_copulation0.79406957
137MP0003119_abnormal_digestive_system0.79371938
138MP0001919_abnormal_reproductive_system0.78934364
139MP0000049_abnormal_middle_ear0.78721759
140MP0001929_abnormal_gametogenesis0.78195228
141MP0006036_abnormal_mitochondrial_physio0.78093124
142MP0002419_abnormal_innate_immunity0.77496812
143MP0002080_prenatal_lethality0.77464184
144MP0001293_anophthalmia0.77253557
145MP0001764_abnormal_homeostasis0.76792934
146MP0000681_abnormal_thyroid_gland0.75456260
147MP0002234_abnormal_pharynx_morphology0.75412220
148MP0010352_gastrointestinal_tract_polyps0.75000190
149MP0006292_abnormal_olfactory_placode0.74394518
150MP0002970_abnormal_white_adipose0.74122681
151MP0003385_abnormal_body_wall0.73579384
152MP0002084_abnormal_developmental_patter0.73420749
153MP0002116_abnormal_craniofacial_bone0.73395854
154MP0000467_abnormal_esophagus_morphology0.72824530
155MP0000653_abnormal_sex_gland0.70493665
156MP0002796_impaired_skin_barrier0.69760601
157MP0003828_pulmonary_edema0.69685232
158MP0001730_embryonic_growth_arrest0.69581096
159MP0008770_decreased_survivor_rate0.69321471
160MP0003186_abnormal_redox_activity0.68931838
161MP0005220_abnormal_exocrine_pancreas0.68920934
162MP0001853_heart_inflammation0.68381152
163MP0002095_abnormal_skin_pigmentation0.64911422

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.62315034
2Increased IgM level (HP:0003496)5.47652144
3Poikiloderma (HP:0001029)5.12369835
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.91467510
5Chromsome breakage (HP:0040012)4.38826065
6Birth length less than 3rd percentile (HP:0003561)4.33154652
7Rectal fistula (HP:0100590)4.01352250
8Rectovaginal fistula (HP:0000143)4.01352250
9Tongue fasciculations (HP:0001308)4.00575076
10Albinism (HP:0001022)3.96430927
11Rib fusion (HP:0000902)3.89083935
12Annular pancreas (HP:0001734)3.77366309
13Intestinal fistula (HP:0100819)3.66397314
14Vaginal fistula (HP:0004320)3.59504935
15Hyperacusis (HP:0010780)3.54416698
16Muscle fibrillation (HP:0010546)3.44233224
17Concave nail (HP:0001598)3.42845228
18Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.33387650
19Breast hypoplasia (HP:0003187)3.23858434
20Abnormality of male internal genitalia (HP:0000022)3.20675809
21Orthostatic hypotension (HP:0001278)3.08816814
22Alopecia of scalp (HP:0002293)3.06623908
23Absent thumb (HP:0009777)3.06402483
24Premature graying of hair (HP:0002216)3.05032859
25Type 2 muscle fiber atrophy (HP:0003554)3.04573561
26Reticulocytopenia (HP:0001896)3.04238901
27Abnormal hemoglobin (HP:0011902)3.02231011
28Muscle fiber atrophy (HP:0100295)3.00964169
29Exertional dyspnea (HP:0002875)2.93084437
30Urinary glycosaminoglycan excretion (HP:0003541)2.92421184
31Mucopolysacchariduria (HP:0008155)2.92421184
32Facial hemangioma (HP:0000329)2.92348207
33Growth hormone excess (HP:0000845)2.90871333
34Short thumb (HP:0009778)2.89172458
35Dysautonomia (HP:0002459)2.83433611
36IgG deficiency (HP:0004315)2.81521959
37Hypokinesia (HP:0002375)2.80877967
38Intestinal atresia (HP:0011100)2.80802758
39Dysostosis multiplex (HP:0000943)2.79337798
40IgA deficiency (HP:0002720)2.78975427
41High anterior hairline (HP:0009890)2.69694755
42Aplasia/Hypoplasia of the uvula (HP:0010293)2.68749089
43Basal cell carcinoma (HP:0002671)2.68292376
44Abnormality of T cell physiology (HP:0011840)2.64198905
45Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.63054040
46Vertebral hypoplasia (HP:0008417)2.63054040
47Cheilitis (HP:0100825)2.59857070
48Meckel diverticulum (HP:0002245)2.59488910
49Ectopic kidney (HP:0000086)2.56672715
50Abnormality of mucopolysaccharide metabolism (HP:0011020)2.56636877
51Abnormality of polysaccharide metabolism (HP:0011012)2.56636877
52Abnormality of glycosaminoglycan metabolism (HP:0004371)2.56636877
53Large for gestational age (HP:0001520)2.56316748
54Abnormality of DNA repair (HP:0003254)2.55450290
55Absent epiphyses (HP:0010577)2.51451016
56Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.51451016
57Abnormality of the carotid arteries (HP:0005344)2.50434588
58Abnormality of the preputium (HP:0100587)2.50425658
59Broad distal phalanx of finger (HP:0009836)2.48512564
60Testicular atrophy (HP:0000029)2.46238156
61Patellar aplasia (HP:0006443)2.44545138
62Hypochromic microcytic anemia (HP:0004840)2.43916314
63Broad alveolar ridges (HP:0000187)2.42393237
64Duplicated collecting system (HP:0000081)2.41874656
65High pitched voice (HP:0001620)2.40874295
66Selective tooth agenesis (HP:0001592)2.40864403
67IgM deficiency (HP:0002850)2.37786489
68Joint stiffness (HP:0001387)2.36909915
69Hypoplasia of the capital femoral epiphysis (HP:0003090)2.36288799
70Congenital hip dislocation (HP:0001374)2.35537754
71Urethral obstruction (HP:0000796)2.34381706
72Microvesicular hepatic steatosis (HP:0001414)2.32767767
73Acute lymphatic leukemia (HP:0006721)2.32524820
74Squamous cell carcinoma (HP:0002860)2.31484778
75Increased nuchal translucency (HP:0010880)2.31253605
76Abnormality of cochlea (HP:0000375)2.30959627
77Bifid uvula (HP:0000193)2.27934283
78Progressive muscle weakness (HP:0003323)2.25614355
79Hypercortisolism (HP:0001578)2.24674885
80Insomnia (HP:0100785)2.24646652
81Aplasia/Hypoplasia of the patella (HP:0006498)2.23539827
82Duplication of thumb phalanx (HP:0009942)2.23293106
83Abnormality of T cells (HP:0002843)2.22068048
84Redundant skin (HP:0001582)2.21076873
85Generalized hypopigmentation (HP:0007513)2.21037015
86Aplasia/hypoplasia of the humerus (HP:0006507)2.20943735
87Ulnar bowing (HP:0003031)2.18274654
88Horseshoe kidney (HP:0000085)2.17707422
89Abnormal number of erythroid precursors (HP:0012131)2.17345582
90Recurrent fungal infections (HP:0002841)2.17148317
91Hypoplasia of the pons (HP:0012110)2.16773568
92Elfin facies (HP:0004428)2.15643965
93Overriding aorta (HP:0002623)2.14910474
94Anteriorly placed anus (HP:0001545)2.14643863
95Male infertility (HP:0003251)2.14630328
96Poor suck (HP:0002033)2.12566955
97Short humerus (HP:0005792)2.11158434
98Abnormality of the anterior horn cell (HP:0006802)2.11079443
99Degeneration of anterior horn cells (HP:0002398)2.11079443
100Type I transferrin isoform profile (HP:0003642)2.10912199
101Abnormality of the aortic arch (HP:0012303)2.10458472
102Abnormality of cells of the erythroid lineage (HP:0012130)2.09751302
103Bulbar palsy (HP:0001283)2.09179398
104Pancreatic islet-cell hyperplasia (HP:0004510)2.09145508
105Hypergammaglobulinemia (HP:0010702)2.06426326
106Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04464256
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04464256
108Abnormality of reticulocytes (HP:0004312)2.04195201
109Abnormality of the ileum (HP:0001549)2.03206307
110Short chin (HP:0000331)2.00736038
111Amniotic constriction ring (HP:0009775)2.00348601
112Abnormality of placental membranes (HP:0011409)2.00348601
113Abnormality of the labia minora (HP:0012880)1.99159426
114Abnormality of the renal collecting system (HP:0004742)1.99068473
115Septate vagina (HP:0001153)1.99025385
116Lymphoma (HP:0002665)1.98738262
117Diaphragmatic weakness (HP:0009113)1.98623532
118Absent radius (HP:0003974)1.98347793
119Small intestinal stenosis (HP:0012848)1.97668543
120Duodenal stenosis (HP:0100867)1.97668543
121Microretrognathia (HP:0000308)1.96685239
122Hypotelorism (HP:0000601)1.94530915
123Morphological abnormality of the inner ear (HP:0011390)1.93747977
124Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93318667
125Atresia of the external auditory canal (HP:0000413)1.93060028
126Elevated erythrocyte sedimentation rate (HP:0003565)1.92965100
127Abnormality of chromosome stability (HP:0003220)1.92358586
128Abnormality of the pons (HP:0007361)1.92262767
129Recurrent abscess formation (HP:0002722)1.90961354
130Proximal placement of thumb (HP:0009623)1.90831423
131Turricephaly (HP:0000262)1.89838404
132Progressive neurologic deterioration (HP:0002344)1.89281018
133Hypochromic anemia (HP:0001931)1.89043736
134Impulsivity (HP:0100710)1.88451241
135Amelogenesis imperfecta (HP:0000705)1.87566063
136Hepatocellular necrosis (HP:0001404)1.87565878
137Optic nerve coloboma (HP:0000588)1.87554961
138Narrow nasal bridge (HP:0000446)1.87546360
139Abnormality of homocysteine metabolism (HP:0010919)1.87330994
140Homocystinuria (HP:0002156)1.87330994
141Capillary hemangiomas (HP:0005306)1.87103636
142Hypoplasia of the radius (HP:0002984)1.86829580
143Popliteal pterygium (HP:0009756)1.86805880
144Renal duplication (HP:0000075)1.86777182
145Lower limb hyperreflexia (HP:0002395)1.86014044
146Ureteral duplication (HP:0000073)1.85328690
147Abnormal number of incisors (HP:0011064)1.84910231
148Diminished movement (HP:0002374)1.83232166
149Triphalangeal thumb (HP:0001199)1.83216507
150Absent forearm bone (HP:0003953)1.82907337
151Aplasia involving forearm bones (HP:0009822)1.82907337
152Deviation of the thumb (HP:0009603)1.82865672
153Sloping forehead (HP:0000340)1.79173852
154Truncus arteriosus (HP:0001660)1.78089309
155Renovascular hypertension (HP:0100817)1.77793277
156Partial agenesis of the corpus callosum (HP:0001338)1.76759091
157Cafe-au-lait spot (HP:0000957)1.76621077
158Pendular nystagmus (HP:0012043)1.76513455
159Myelodysplasia (HP:0002863)1.75944004
16011 pairs of ribs (HP:0000878)1.75593705
161Spina bifida occulta (HP:0003298)1.74519031
162Bowed forearm bones (HP:0003956)1.73495935
163Bowing of the arm (HP:0006488)1.73495935
164Delayed epiphyseal ossification (HP:0002663)1.73291306
165Slender long bone (HP:0003100)1.71225394
166Cerebellar dysplasia (HP:0007033)1.70407633
167Bilateral microphthalmos (HP:0007633)1.67336732
168Flat cornea (HP:0007720)1.63282192
169Long palpebral fissure (HP:0000637)1.62834476
170Abnormality of the fingertips (HP:0001211)1.62711490
171Pseudobulbar signs (HP:0002200)1.62549076
172Neoplasm of the adrenal cortex (HP:0100641)1.62039124
173Glossoptosis (HP:0000162)1.61878440
174Clubbing of toes (HP:0100760)1.61001748
175Broad face (HP:0000283)1.60254970

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK154.16903041
2TRIB34.12738015
3ICK4.11624588
4MAP3K113.88672334
5EEF2K3.87476655
6SMG13.84364908
7MAP3K63.69629928
8PIM23.51975721
9DAPK13.28437534
10DDR23.27817080
11CDK123.00411685
12MATK2.97859703
13PINK12.95793121
14MAP3K102.57492723
15IRAK32.42126226
16YES12.33674970
17SIK12.15814557
18ZAK2.14982702
19MAP4K12.11120889
20MST1R2.04929935
21FGR2.03027966
22TTK1.99078962
23EPHA21.97700480
24CSK1.92204130
25VRK21.86961985
26UHMK11.85422003
27PRKD21.84265097
28MAP3K121.83770494
29AKT31.77562238
30PIM11.73542743
31BMX1.66747364
32TYRO31.58685170
33CDK71.56472542
34TXK1.47266831
35SRPK11.46341495
36PKN21.45624312
37CAMK1D1.44344114
38RPS6KC11.42840835
39RPS6KL11.42840835
40RPS6KA61.41900824
41CDK41.41044384
42PRPF4B1.40850047
43WNK41.36826281
44BLK1.36804447
45TAOK21.36686213
46DYRK1B1.30855444
47MTOR1.25221462
48SIK21.24714918
49BUB11.23408746
50TRPM71.20450602
51CHEK11.19577172
52NME21.12299641
53MET1.11070640
54STK161.10649889
55ZAP701.09667610
56AURKB1.08762323
57MAP3K81.07481089
58TNK21.05339501
59PLK41.04084748
60EIF2AK11.02203622
61TESK21.00410564
62SIK30.98338601
63LYN0.95245425
64TAF10.94559715
65MAPK110.93028555
66PLK10.89818136
67RPS6KB20.86997277
68RAF10.85927556
69CAMK1G0.85819482
70TLK10.83805630
71MAP2K20.83061935
72CDK10.82195558
73ERBB30.81596359
74CHEK20.81198855
75ATR0.80711979
76MAPKAPK30.78807448
77PASK0.77667949
78PRKD30.76198517
79BRD40.74464179
80CDK80.74163290
81WEE10.74089793
82PDGFRA0.73584785
83PTK60.73251361
84KIT0.72578327
85CDK190.70714590
86ATM0.69714485
87CDC42BPA0.68378809
88IRAK20.67508748
89DYRK30.65439798
90TTN0.64656471
91CDK60.64329368
92IKBKB0.64178476
93LCK0.63868676
94CSNK2A10.63394434
95SYK0.61873093
96STK40.61429475
97TBK10.58439796
98PBK0.57563523
99AKT20.57393149
100TEC0.57149389
101MKNK10.57122701
102BTK0.56325645
103PAK40.56298409
104ARAF0.56245140
105PHKG10.54199813
106PHKG20.54199813
107KDR0.54051372
108RPS6KA10.54051024
109HIPK20.52841314
110TSSK60.51880154
111RPS6KA20.50434485
112RPS6KB10.49549732
113MUSK0.48790432
114FGFR40.47719178
115PRKCD0.47643132
116VRK10.47360844
117GSK3A0.46852309
118CCNB10.46462715
119SCYL20.46383217
120RPS6KA40.46376091
121FLT30.46297799
122AURKA0.44670601
123ILK0.44534504
124MELK0.44218801
125MKNK20.44204647
126PTK20.43704844
127MAPK140.42961912
128MAPK30.42347667
129IKBKE0.40635976
130AKT10.39841349
131CDK90.39686700
132JAK30.39219603
133PRKCI0.38669467
134CSNK2A20.38609219
135RPS6KA50.38222978
136NEK10.38001463
137CLK10.37847098
138BRAF0.37008940
139GSK3B0.36422577
140IRAK40.36034454
141MAPK40.35280814
142BRSK20.33645046
143GRK60.33606954
144MAPKAPK20.33567950
145MYLK0.33148204
146PRKDC0.33081198
147PLK30.33044588
148DYRK20.31877882
149PRKAA10.31771837
150NEK20.31161799
151BRSK10.31142530
152MAP3K140.30757552
153CHUK0.30507576
154NME10.30263529
155MAPKAPK50.29883756
156TYK20.29844991
157CDC70.28424989
158CDK20.28382412
159MAP2K60.28338666
160EIF2AK20.25250655

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.87945560
2Base excision repair_Homo sapiens_hsa034104.73068658
3DNA replication_Homo sapiens_hsa030304.47946305
4Proteasome_Homo sapiens_hsa030503.04091361
5Ribosome_Homo sapiens_hsa030102.79586206
6Nucleotide excision repair_Homo sapiens_hsa034202.63535215
7Fatty acid biosynthesis_Homo sapiens_hsa000612.49466660
8Primary immunodeficiency_Homo sapiens_hsa053402.45463755
9Homologous recombination_Homo sapiens_hsa034402.37648248
10Spliceosome_Homo sapiens_hsa030402.34947849
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.25258292
12Cyanoamino acid metabolism_Homo sapiens_hsa004602.00618095
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.91920136
14Lysine degradation_Homo sapiens_hsa003101.90033100
15Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.89610877
16RNA polymerase_Homo sapiens_hsa030201.82301728
17RNA transport_Homo sapiens_hsa030131.77295776
18Selenocompound metabolism_Homo sapiens_hsa004501.72225807
19Fanconi anemia pathway_Homo sapiens_hsa034601.64707021
20Fructose and mannose metabolism_Homo sapiens_hsa000511.61324388
21Legionellosis_Homo sapiens_hsa051341.48750889
22Oxidative phosphorylation_Homo sapiens_hsa001901.48674241
23Pyrimidine metabolism_Homo sapiens_hsa002401.47760791
24Sulfur relay system_Homo sapiens_hsa041221.46584934
25Parkinsons disease_Homo sapiens_hsa050121.41924150
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.41534477
27Shigellosis_Homo sapiens_hsa051311.32334744
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30806699
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23185466
30p53 signaling pathway_Homo sapiens_hsa041151.21941120
31mRNA surveillance pathway_Homo sapiens_hsa030151.20970818
32Basal cell carcinoma_Homo sapiens_hsa052171.20848804
33Biosynthesis of amino acids_Homo sapiens_hsa012301.19573871
34Cell cycle_Homo sapiens_hsa041101.18502917
35Galactose metabolism_Homo sapiens_hsa000521.15839452
36Folate biosynthesis_Homo sapiens_hsa007901.08826554
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06274088
38Vitamin B6 metabolism_Homo sapiens_hsa007501.05400672
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.03267982
40Huntingtons disease_Homo sapiens_hsa050161.03263503
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97939371
42Notch signaling pathway_Homo sapiens_hsa043300.97175838
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.95692597
44Measles_Homo sapiens_hsa051620.93186733
45Circadian rhythm_Homo sapiens_hsa047100.90836531
46Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89825374
47Epstein-Barr virus infection_Homo sapiens_hsa051690.87448031
48Herpes simplex infection_Homo sapiens_hsa051680.86295832
49Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86131549
50Intestinal immune network for IgA production_Homo sapiens_hsa046720.85619738
51Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83014661
52MicroRNAs in cancer_Homo sapiens_hsa052060.80910031
53Chronic myeloid leukemia_Homo sapiens_hsa052200.79838507
54Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.79683102
55Arginine and proline metabolism_Homo sapiens_hsa003300.78838382
56mTOR signaling pathway_Homo sapiens_hsa041500.76750829
57N-Glycan biosynthesis_Homo sapiens_hsa005100.76662576
58Acute myeloid leukemia_Homo sapiens_hsa052210.74438109
59RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.73970585
60RNA degradation_Homo sapiens_hsa030180.73349865
61Collecting duct acid secretion_Homo sapiens_hsa049660.71633226
62Antigen processing and presentation_Homo sapiens_hsa046120.70948787
63Carbon metabolism_Homo sapiens_hsa012000.70613728
64Allograft rejection_Homo sapiens_hsa053300.70400728
65Bladder cancer_Homo sapiens_hsa052190.68554410
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.67886107
67Pyruvate metabolism_Homo sapiens_hsa006200.67527601
68Basal transcription factors_Homo sapiens_hsa030220.65260633
69Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65027667
70Non-small cell lung cancer_Homo sapiens_hsa052230.63868504
71Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62446562
72Non-homologous end-joining_Homo sapiens_hsa034500.61171235
73Small cell lung cancer_Homo sapiens_hsa052220.60901801
74Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.60544334
75Alcoholism_Homo sapiens_hsa050340.59567987
76Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59533673
77Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59396015
78Alzheimers disease_Homo sapiens_hsa050100.57608404
79Leishmaniasis_Homo sapiens_hsa051400.57571350
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56110082
81One carbon pool by folate_Homo sapiens_hsa006700.55817760
82B cell receptor signaling pathway_Homo sapiens_hsa046620.55568155
83Pentose phosphate pathway_Homo sapiens_hsa000300.54186659
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53944602
85Hematopoietic cell lineage_Homo sapiens_hsa046400.52491049
86Salmonella infection_Homo sapiens_hsa051320.51855665
87Phagosome_Homo sapiens_hsa041450.51288922
88Purine metabolism_Homo sapiens_hsa002300.51125917
89Type I diabetes mellitus_Homo sapiens_hsa049400.51016145
90AMPK signaling pathway_Homo sapiens_hsa041520.50805671
91Thyroid cancer_Homo sapiens_hsa052160.50704014
92Colorectal cancer_Homo sapiens_hsa052100.49453873
93Viral myocarditis_Homo sapiens_hsa054160.49138517
94Synaptic vesicle cycle_Homo sapiens_hsa047210.48932644
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45918319
96Lysosome_Homo sapiens_hsa041420.45606406
97Wnt signaling pathway_Homo sapiens_hsa043100.45508139
98Hepatitis B_Homo sapiens_hsa051610.45171157
99Apoptosis_Homo sapiens_hsa042100.44947816
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44038640
101Viral carcinogenesis_Homo sapiens_hsa052030.43970844
102Asthma_Homo sapiens_hsa053100.43785683
103VEGF signaling pathway_Homo sapiens_hsa043700.43758566
104Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43752366
105Systemic lupus erythematosus_Homo sapiens_hsa053220.43686614
106Prostate cancer_Homo sapiens_hsa052150.42805630
107Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42341919
108Vibrio cholerae infection_Homo sapiens_hsa051100.42225302
109Protein export_Homo sapiens_hsa030600.41911605
110Melanoma_Homo sapiens_hsa052180.41078977
111Graft-versus-host disease_Homo sapiens_hsa053320.40031389
112Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.39336302
113Vitamin digestion and absorption_Homo sapiens_hsa049770.38680002
114Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38202410
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.37983902
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37640520
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36757776
118Metabolic pathways_Homo sapiens_hsa011000.36383565
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.35402193
120Oocyte meiosis_Homo sapiens_hsa041140.34304787
121Hippo signaling pathway_Homo sapiens_hsa043900.33759262
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32821039
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32191897
124Pancreatic cancer_Homo sapiens_hsa052120.31530409
125Pentose and glucuronate interconversions_Homo sapiens_hsa000400.30778967
126Glucagon signaling pathway_Homo sapiens_hsa049220.30533863
127Glutathione metabolism_Homo sapiens_hsa004800.30409545
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.29435514
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28921111
130Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28878860
131Hedgehog signaling pathway_Homo sapiens_hsa043400.28816644
132Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28419713
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.27571527
134Endometrial cancer_Homo sapiens_hsa052130.27446029
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.26740159
136Rheumatoid arthritis_Homo sapiens_hsa053230.25221339
137Melanogenesis_Homo sapiens_hsa049160.25126160
138HTLV-I infection_Homo sapiens_hsa051660.24738734
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.24088404
140Glioma_Homo sapiens_hsa052140.23115418
141Arginine biosynthesis_Homo sapiens_hsa002200.22212988
142Insulin signaling pathway_Homo sapiens_hsa049100.22064595
143ErbB signaling pathway_Homo sapiens_hsa040120.21476526
144Steroid biosynthesis_Homo sapiens_hsa001000.21025365
145Inositol phosphate metabolism_Homo sapiens_hsa005620.17834256

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