TOMM40

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.90624648
2formation of translation preinitiation complex (GO:0001731)5.01168106
3DNA strand elongation involved in DNA replication (GO:0006271)4.78918314
4folic acid-containing compound biosynthetic process (GO:0009396)4.72311509
5DNA unwinding involved in DNA replication (GO:0006268)4.65523914
6maturation of SSU-rRNA (GO:0030490)4.60456166
7nucleobase biosynthetic process (GO:0046112)4.59998086
8DNA replication initiation (GO:0006270)4.55114321
9DNA strand elongation (GO:0022616)4.49889361
10mitotic chromosome condensation (GO:0007076)4.46009776
11viral transcription (GO:0019083)4.45816191
12proline biosynthetic process (GO:0006561)4.42592807
13ribosome biogenesis (GO:0042254)4.42352911
14telomere maintenance via semi-conservative replication (GO:0032201)4.39223931
15translational termination (GO:0006415)4.36207236
16heterochromatin organization (GO:0070828)4.33517212
17ribosome assembly (GO:0042255)4.32557632
18purine nucleobase biosynthetic process (GO:0009113)4.20904593
19ribonucleoprotein complex biogenesis (GO:0022613)4.19283815
20ribosomal small subunit biogenesis (GO:0042274)4.15941326
21translational elongation (GO:0006414)4.13803384
22translational initiation (GO:0006413)4.12065075
23folic acid metabolic process (GO:0046655)4.11491306
24ribosomal small subunit assembly (GO:0000028)4.10816485
25ribosomal large subunit biogenesis (GO:0042273)4.02202524
26IMP biosynthetic process (GO:0006188)3.94026122
27protein localization to kinetochore (GO:0034501)3.89293339
28pseudouridine synthesis (GO:0001522)3.81986718
29DNA replication checkpoint (GO:0000076)3.81916297
30spliceosomal tri-snRNP complex assembly (GO:0000244)3.80587505
31mitotic nuclear envelope disassembly (GO:0007077)3.78759880
32DNA replication-dependent nucleosome organization (GO:0034723)3.77348986
33DNA replication-dependent nucleosome assembly (GO:0006335)3.77348986
34spliceosomal snRNP assembly (GO:0000387)3.77174975
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.72354437
36peptidyl-arginine N-methylation (GO:0035246)3.70985218
37peptidyl-arginine methylation (GO:0018216)3.70985218
38nucleobase-containing small molecule interconversion (GO:0015949)3.70322007
39regulation of mammary gland epithelial cell proliferation (GO:0033599)3.69903841
40rRNA processing (GO:0006364)3.69799781
41proteasome assembly (GO:0043248)3.68643186
42telomere maintenance via recombination (GO:0000722)3.64273873
43rRNA metabolic process (GO:0016072)3.56590728
44rRNA transcription (GO:0009303)3.56505326
45mitotic metaphase plate congression (GO:0007080)3.56446949
46nuclear pore complex assembly (GO:0051292)3.56243440
47regulation of translational termination (GO:0006449)3.55730624
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53367243
49telomere maintenance via telomere lengthening (GO:0010833)3.49520416
50nuclear envelope disassembly (GO:0051081)3.49317184
51membrane disassembly (GO:0030397)3.49317184
52regulation of translational fidelity (GO:0006450)3.49087283
53negative regulation of mRNA processing (GO:0050686)3.48260668
54cellular protein complex disassembly (GO:0043624)3.47016775
55IMP metabolic process (GO:0046040)3.46179606
56peptidyl-arginine omega-N-methylation (GO:0035247)3.46163850
57regulation of posttranscriptional gene silencing (GO:0060147)3.45037891
58regulation of gene silencing by miRNA (GO:0060964)3.45037891
59regulation of gene silencing by RNA (GO:0060966)3.45037891
60protein targeting to ER (GO:0045047)3.42560867
61cotranslational protein targeting to membrane (GO:0006613)3.41759930
62viral life cycle (GO:0019058)3.40324815
63mitotic recombination (GO:0006312)3.39724779
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.39378336
65protein localization to chromosome, centromeric region (GO:0071459)3.38834489
66histone arginine methylation (GO:0034969)3.36131881
67establishment of integrated proviral latency (GO:0075713)3.35295601
68protein-DNA complex disassembly (GO:0032986)3.28700324
69nucleosome disassembly (GO:0006337)3.28700324
70pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.27195198
71cellular protein complex localization (GO:0034629)3.26891855
72translation (GO:0006412)3.26409352
73sister chromatid segregation (GO:0000819)3.26176600
74establishment of protein localization to endoplasmic reticulum (GO:0072599)3.24817986
75nucleotide-excision repair, DNA gap filling (GO:0006297)3.24210135
76negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.23250527
77negative regulation of mRNA metabolic process (GO:1903312)3.22508048
78protein localization to endoplasmic reticulum (GO:0070972)3.22415724
79negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.22277343
80pteridine-containing compound biosynthetic process (GO:0042559)3.21834268
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.20882268
82pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.20865008
83rRNA modification (GO:0000154)3.20116090
84protein complex disassembly (GO:0043241)3.19808418
85ncRNA 3-end processing (GO:0043628)3.19520607
86protein complex localization (GO:0031503)3.19159418
87pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.18174727
88chromatin assembly (GO:0031497)3.17570232
89protein maturation by protein folding (GO:0022417)3.13850608
90mitotic sister chromatid segregation (GO:0000070)3.11448786
91cellular component biogenesis (GO:0044085)3.10928999
92transcription from mitochondrial promoter (GO:0006390)3.09942411
93somatic hypermutation of immunoglobulin genes (GO:0016446)3.09115933
94somatic diversification of immune receptors via somatic mutation (GO:0002566)3.09115933
95regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08713747
96mitotic nuclear envelope reassembly (GO:0007084)3.08292847
97nuclear envelope reassembly (GO:0031468)3.08292847
98mitotic G1 DNA damage checkpoint (GO:0031571)3.07518962
99tRNA methylation (GO:0030488)3.07195785
100positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.06864571
101mitochondrial fusion (GO:0008053)3.06583669
102negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.05287687
103tRNA aminoacylation for protein translation (GO:0006418)3.04568928
104nuclear pore organization (GO:0006999)3.03991754
105DNA duplex unwinding (GO:0032508)3.03734528
106macromolecular complex disassembly (GO:0032984)3.03695119
107L-serine metabolic process (GO:0006563)3.01454106
108DNA geometric change (GO:0032392)3.01238654
109establishment of protein localization to mitochondrial membrane (GO:0090151)2.99478475
110DNA topological change (GO:0006265)2.98945483
111negative regulation of ligase activity (GO:0051352)2.98905693
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.98905693
113proline metabolic process (GO:0006560)2.98674360
114transcription-coupled nucleotide-excision repair (GO:0006283)2.96236340
115amino acid activation (GO:0043038)2.95868599
116tRNA aminoacylation (GO:0043039)2.95868599
117spliceosomal complex assembly (GO:0000245)2.95333131
118Golgi transport vesicle coating (GO:0048200)2.95283099
119COPI coating of Golgi vesicle (GO:0048205)2.95283099
120pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.93362881
121viral mRNA export from host cell nucleus (GO:0046784)2.92709071
122apoptotic process involved in morphogenesis (GO:0060561)2.91693039
123nuclear-transcribed mRNA catabolic process (GO:0000956)2.91157752
124negative regulation of RNA splicing (GO:0033119)2.91120216
125metaphase plate congression (GO:0051310)2.89218981
126termination of RNA polymerase III transcription (GO:0006386)2.88956605
127transcription elongation from RNA polymerase III promoter (GO:0006385)2.88956605
128cell cycle G1/S phase transition (GO:0044843)2.88652174
129G1/S transition of mitotic cell cycle (GO:0000082)2.88652174
130regulation of mitochondrial translation (GO:0070129)2.87002909
131regulation of translational elongation (GO:0006448)2.85896512
132mRNA splicing, via spliceosome (GO:0000398)2.85605609
133RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.85605609
134mitochondrial RNA metabolic process (GO:0000959)2.85479800
135RNA splicing, via transesterification reactions (GO:0000375)2.85234355
136UTP biosynthetic process (GO:0006228)2.83377159
137pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.83365908
138deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83272332
139regulation of spindle organization (GO:0090224)2.83167940
140positive regulation of chromosome segregation (GO:0051984)2.81118595
141pentose-phosphate shunt (GO:0006098)2.81041736
142chromosome condensation (GO:0030261)2.80303191
143pore complex assembly (GO:0046931)2.78195648
144negative regulation of cell size (GO:0045792)2.75645715
145establishment of viral latency (GO:0019043)2.75098116
146pentose metabolic process (GO:0019321)2.74905503
147DNA conformation change (GO:0071103)2.74016737
148positive regulation of DNA-dependent DNA replication (GO:2000105)2.73648437
149pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.71734307

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.34831294
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.45370900
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.19497022
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.20345068
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.12417970
6* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.01475693
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85428731
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.84060783
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.81266350
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69504364
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55573813
12* EST1_17652178_ChIP-ChIP_JURKAT_Human2.54625526
13* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44769400
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.44110468
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.39540060
16* XRN2_22483619_ChIP-Seq_HELA_Human2.39432150
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.33131313
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.25628393
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20357919
20E2F1_18555785_ChIP-Seq_MESCs_Mouse2.05235340
21NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01123559
22CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.95460313
23THAP11_20581084_ChIP-Seq_MESCs_Mouse1.91721794
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.87225832
25VDR_23849224_ChIP-Seq_CD4+_Human1.87225385
26GABP_19822575_ChIP-Seq_HepG2_Human1.85874667
27MYC_22102868_ChIP-Seq_BL_Human1.84953941
28DCP1A_22483619_ChIP-Seq_HELA_Human1.83326846
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78901438
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78506340
31* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77406108
32* SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.76617774
33YY1_21170310_ChIP-Seq_MESCs_Mouse1.76373488
34TTF2_22483619_ChIP-Seq_HELA_Human1.71743220
35LXR_22292898_ChIP-Seq_THP-1_Human1.71375788
36STAT3_1855785_ChIP-Seq_MESCs_Mouse1.69686527
37FOXP3_21729870_ChIP-Seq_TREG_Human1.68189840
38* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66674979
39AR_21909140_ChIP-Seq_LNCAP_Human1.66607119
40ZFX_18555785_ChIP-Seq_MESCs_Mouse1.61198671
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.58173176
42CIITA_25753668_ChIP-Seq_RAJI_Human1.58087571
43ELK3_25401928_ChIP-Seq_HUVEC_Human1.55683384
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51639067
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.51239858
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50250889
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47330802
48RACK7_27058665_Chip-Seq_MCF-7_Human1.47152889
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.46128981
50ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44855674
51KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44834968
52* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.44581951
53DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.43842474
54KDM5A_27292631_Chip-Seq_BREAST_Human1.40997357
55E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40776790
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.40766080
57SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39788767
58POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39402325
59* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39070614
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38908332
61EGR1_19374776_ChIP-ChIP_THP-1_Human1.37161091
62* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32073831
63* VDR_21846776_ChIP-Seq_THP-1_Human1.30642030
64* P68_20966046_ChIP-Seq_HELA_Human1.27218543
65ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26642049
66TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26191599
67YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25571991
68PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25114040
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.23540030
70NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.23420854
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.23040021
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.23040021
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.23040021
74SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.22655503
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.22635920
76ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22603976
77ZNF263_19887448_ChIP-Seq_K562_Human1.22101575
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22023171
79SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.16769224
80SRF_21415370_ChIP-Seq_HL-1_Mouse1.16178952
81NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15542980
82* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14959947
83NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13843764
84NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.12574858
85* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12451832
86SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.11675904
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10319638
88RARG_19884340_ChIP-ChIP_MEFs_Mouse1.10228832
89TFEB_21752829_ChIP-Seq_HELA_Human1.10225424
90SOX2_18555785_ChIP-Seq_MESCs_Mouse1.08965811
91* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.08733294
92* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.07202502
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06790735
94* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06364948
95FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.05394456
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05057451
97* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.03689449
98SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02949266
99KDM2B_26808549_Chip-Seq_DND41_Human1.01781514
100KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01685682
101CTCF_18555785_ChIP-Seq_MESCs_Mouse1.01585429
102KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00739536
103PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.99987894
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.99962506
105UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99616782
106* SA1_27219007_Chip-Seq_ERYTHROID_Human0.99408897
107E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.99259085
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98902466
109YY1_22570637_ChIP-Seq_MALME-3M_Human0.98311165
110NCOR1_26117541_ChIP-Seq_K562_Human0.98119813
111ELF1_20517297_ChIP-Seq_JURKAT_Human0.97796430
112FOXP1_21924763_ChIP-Seq_HESCs_Human0.97289777
113TCF7_22412390_ChIP-Seq_EML_Mouse0.97085291
114* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96649848
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96287100
116* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95691773
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.94708032
118EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94392795
119* ELK1_19687146_ChIP-ChIP_HELA_Human0.93222765
120CTCF_27219007_Chip-Seq_ERYTHROID_Human0.92902849
121ERG_20887958_ChIP-Seq_HPC-7_Mouse0.92483159
122NANOG_21062744_ChIP-ChIP_HESCs_Human0.91314700
123ATF3_27146783_Chip-Seq_COLON_Human0.91193529
124* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90516695
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.89963217
126* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.89419094
127* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89018158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.79595346
2MP0004957_abnormal_blastocyst_morpholog4.81540769
3MP0003111_abnormal_nucleus_morphology4.62928208
4MP0010094_abnormal_chromosome_stability3.91085761
5MP0003077_abnormal_cell_cycle3.80467940
6MP0008057_abnormal_DNA_replication3.25372124
7MP0002877_abnormal_melanocyte_morpholog2.92642105
8MP0005451_abnormal_body_composition2.89802834
9MP0008932_abnormal_embryonic_tissue2.81572348
10MP0003806_abnormal_nucleotide_metabolis2.78430955
11MP0001730_embryonic_growth_arrest2.75516915
12MP0008058_abnormal_DNA_repair2.68767927
13MP0010352_gastrointestinal_tract_polyps2.60201038
14MP0004185_abnormal_adipocyte_glucose2.38678754
15MP0000350_abnormal_cell_proliferation2.34506468
16MP0008007_abnormal_cellular_replicative2.28033511
17MP0010234_abnormal_vibrissa_follicle2.10309670
18MP0001672_abnormal_embryogenesis/_devel2.00964641
19MP0005380_embryogenesis_phenotype2.00964641
20MP0010030_abnormal_orbit_morphology1.98092792
21MP0003123_paternal_imprinting1.97726039
22MP0001697_abnormal_embryo_size1.97296652
23MP0002653_abnormal_ependyma_morphology1.96023404
24MP0004133_heterotaxia1.91877052
25MP0002080_prenatal_lethality1.88529407
26MP0003718_maternal_effect1.83877208
27MP0004858_abnormal_nervous_system1.81888635
28MP0002085_abnormal_embryonic_tissue1.80010288
29MP0000678_abnormal_parathyroid_gland1.79787411
30MP0009840_abnormal_foam_cell1.79216055
31MP0003984_embryonic_growth_retardation1.77600668
32MP0003786_premature_aging1.75373769
33MP0002088_abnormal_embryonic_growth/wei1.72955727
34MP0000490_abnormal_crypts_of1.69191605
35MP0002084_abnormal_developmental_patter1.66883270
36MP0002396_abnormal_hematopoietic_system1.66717186
37MP0002796_impaired_skin_barrier1.65658214
38MP0005058_abnormal_lysosome_morphology1.60945591
39MP0002086_abnormal_extraembryonic_tissu1.57332271
40MP0000313_abnormal_cell_death1.56921179
41MP0003119_abnormal_digestive_system1.55881435
42MP0004197_abnormal_fetal_growth/weight/1.50108531
43MP0002163_abnormal_gland_morphology1.47213410
44MP0000358_abnormal_cell_content/1.46401399
45MP0003705_abnormal_hypodermis_morpholog1.46002158
46MP0000750_abnormal_muscle_regeneration1.44047375
47MP0010307_abnormal_tumor_latency1.43689522
48MP0003283_abnormal_digestive_organ1.43013965
49MP0003567_abnormal_fetal_cardiomyocyte1.42692552
50MP0000566_synostosis1.40297915
51MP0001661_extended_life_span1.38697311
52MP0002019_abnormal_tumor_incidence1.38259125
53MP0003453_abnormal_keratinocyte_physiol1.31746408
54MP0000003_abnormal_adipose_tissue1.31088197
55MP0009333_abnormal_splenocyte_physiolog1.30052023
56MP0006035_abnormal_mitochondrial_morpho1.29164515
57MP0004233_abnormal_muscle_weight1.27847363
58MP0001293_anophthalmia1.27598979
59MP0002249_abnormal_larynx_morphology1.26204917
60MP0000537_abnormal_urethra_morphology1.23522898
61MP0003186_abnormal_redox_activity1.20854741
62MP0005623_abnormal_meninges_morphology1.20407506
63MP0002269_muscular_atrophy1.16835655
64MP0003890_abnormal_embryonic-extraembry1.13824980
65MP0006036_abnormal_mitochondrial_physio1.13666347
66MP0008260_abnormal_autophagy1.11955882
67MP0005397_hematopoietic_system_phenotyp1.11179207
68MP0001545_abnormal_hematopoietic_system1.11179207
69MP0001346_abnormal_lacrimal_gland1.10801109
70MP0009379_abnormal_foot_pigmentation1.10436288
71MP0003221_abnormal_cardiomyocyte_apopto1.08407464
72MP0005257_abnormal_intraocular_pressure1.06674576
73MP0005076_abnormal_cell_differentiation1.05062434
74MP0005666_abnormal_adipose_tissue1.02369159
75MP0003315_abnormal_perineum_morphology1.02311803
76MP0002098_abnormal_vibrissa_morphology0.98664744
77MP0002111_abnormal_tail_morphology0.97211794
78MP0005375_adipose_tissue_phenotype0.96969102
79MP0000733_abnormal_muscle_development0.96637125
80MP0005266_abnormal_metabolism0.96595772
81MP0009053_abnormal_anal_canal0.96447390
82MP0005330_cardiomyopathy0.96383997
83MP0002160_abnormal_reproductive_system0.93471596
84MP0008877_abnormal_DNA_methylation0.92991171
85MP0005023_abnormal_wound_healing0.91915301
86MP0003566_abnormal_cell_adhesion0.91492394
87MP0001348_abnormal_lacrimal_gland0.91358626
88MP0005384_cellular_phenotype0.88548443
89MP0001216_abnormal_epidermal_layer0.88214719
90MP0009672_abnormal_birth_weight0.87233184
91MP0001849_ear_inflammation0.86660705
92MP0002697_abnormal_eye_size0.86255489
93MP0000703_abnormal_thymus_morphology0.83860462
94MP0003942_abnormal_urinary_system0.83702420
95MP0001145_abnormal_male_reproductive0.82838184
96MP0005621_abnormal_cell_physiology0.80778824
97MP0008770_decreased_survivor_rate0.80599050
98MP0004084_abnormal_cardiac_muscle0.80461574
99MP0000467_abnormal_esophagus_morphology0.79759575
100MP0001727_abnormal_embryo_implantation0.79307294
101MP0005501_abnormal_skin_physiology0.78207125
102MP0000858_altered_metastatic_potential0.77480806
103MP0001881_abnormal_mammary_gland0.77446355
104MP0000477_abnormal_intestine_morphology0.77072274
105MP0002132_abnormal_respiratory_system0.76932773
106MP0002210_abnormal_sex_determination0.76609412
107MP0002722_abnormal_immune_system0.76481239
108MP0003385_abnormal_body_wall0.76333467
109MP0009931_abnormal_skin_appearance0.75241681
110MP0000762_abnormal_tongue_morphology0.75146928
111MP0009278_abnormal_bone_marrow0.74648430
112MP0000747_muscle_weakness0.74263651
113MP0004808_abnormal_hematopoietic_stem0.73991533
114MP0000759_abnormal_skeletal_muscle0.72295623
115MP0000579_abnormal_nail_morphology0.71435159
116MP0002060_abnormal_skin_morphology0.70873722
117MP0000689_abnormal_spleen_morphology0.70559066
118MP0000428_abnormal_craniofacial_morphol0.68646194
119MP0003646_muscle_fatigue0.67978262
120MP0003115_abnormal_respiratory_system0.65814500
121MP0003941_abnormal_skin_development0.65550538
122MP0001915_intracranial_hemorrhage0.64188926
123MP0006292_abnormal_olfactory_placode0.60739367
124MP0002127_abnormal_cardiovascular_syste0.59411639
125MP0005670_abnormal_white_adipose0.59312587
126MP0003878_abnormal_ear_physiology0.59087883
127MP0005377_hearing/vestibular/ear_phenot0.59087883
128MP0005389_reproductive_system_phenotype0.58844772
129MP0000653_abnormal_sex_gland0.58082354
130MP0002089_abnormal_postnatal_growth/wei0.58044059
131MP0003763_abnormal_thymus_physiology0.58024007
132MP0002092_abnormal_eye_morphology0.56576304
133MP0002970_abnormal_white_adipose0.56528897
134MP0010630_abnormal_cardiac_muscle0.56058312
135MP0001853_heart_inflammation0.54178125
136MP0000266_abnormal_heart_morphology0.53822090

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.69758506
2Abnormal number of erythroid precursors (HP:0012131)4.45693873
3Breast hypoplasia (HP:0003187)4.19763356
4Reticulocytopenia (HP:0001896)4.12039693
5Birth length less than 3rd percentile (HP:0003561)4.11319321
6Hyperacusis (HP:0010780)3.91680786
7Oral leukoplakia (HP:0002745)3.86831595
8Selective tooth agenesis (HP:0001592)3.79693003
9Ependymoma (HP:0002888)3.75484707
10Cerebral hypomyelination (HP:0006808)3.67095936
11Trismus (HP:0000211)3.51920032
12Carpal bone hypoplasia (HP:0001498)3.50908103
13Rough bone trabeculation (HP:0100670)3.37982663
14Multiple enchondromatosis (HP:0005701)3.32398950
15Abnormality of the anterior horn cell (HP:0006802)3.27696335
16Degeneration of anterior horn cells (HP:0002398)3.27696335
17Macrocytic anemia (HP:0001972)3.22525849
18Progressive muscle weakness (HP:0003323)3.17522449
19Patellar aplasia (HP:0006443)3.03308925
20Microretrognathia (HP:0000308)3.02575758
21Achilles tendon contracture (HP:0001771)3.01467189
22Colon cancer (HP:0003003)3.01391795
23Aplasia/Hypoplasia of the patella (HP:0006498)2.97104780
24Broad distal phalanx of finger (HP:0009836)2.92143025
25Pallor (HP:0000980)2.92038694
26Absent radius (HP:0003974)2.91990702
27Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.87293692
28Insomnia (HP:0100785)2.85871408
29Absent thumb (HP:0009777)2.84080703
30Ulnar bowing (HP:0003031)2.80655359
31Absent forearm bone (HP:0003953)2.72528584
32Aplasia involving forearm bones (HP:0009822)2.72528584
33Premature ovarian failure (HP:0008209)2.63226685
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.61409590
35Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.61409590
36Abnormality of the Achilles tendon (HP:0005109)2.61303248
37Medulloblastoma (HP:0002885)2.61194182
38Chromsome breakage (HP:0040012)2.56815346
39Aplastic anemia (HP:0001915)2.54516248
40Abnormal number of incisors (HP:0011064)2.53789294
41Basal cell carcinoma (HP:0002671)2.49590676
42Neoplasm of the pancreas (HP:0002894)2.48413859
43Angiofibromas (HP:0010615)2.45023847
44Adenoma sebaceum (HP:0009720)2.45023847
45Aplasia/hypoplasia of the humerus (HP:0006507)2.44972852
46Premature graying of hair (HP:0002216)2.44111442
47Atrophy/Degeneration involving motor neurons (HP:0007373)2.42490032
48Overriding aorta (HP:0002623)2.41935800
49Distal lower limb amyotrophy (HP:0008944)2.39182942
50Septate vagina (HP:0001153)2.37587917
51Long palpebral fissure (HP:0000637)2.30509038
52Rhabdomyosarcoma (HP:0002859)2.29958766
53Abnormality of reticulocytes (HP:0004312)2.29446930
54Abdominal situs inversus (HP:0003363)2.28950491
55Abnormality of abdominal situs (HP:0011620)2.28950491
56Deviation of the thumb (HP:0009603)2.27580438
57Proximal placement of thumb (HP:0009623)2.27548331
58High anterior hairline (HP:0009890)2.25890798
59Abnormal trabecular bone morphology (HP:0100671)2.25675601
60Elfin facies (HP:0004428)2.24198841
61Abnormality of the astrocytes (HP:0100707)2.22653654
62Astrocytoma (HP:0009592)2.22653654
63Increased serum lactate (HP:0002151)2.21828860
64Horseshoe kidney (HP:0000085)2.20975651
65Reticulocytosis (HP:0001923)2.18600639
66Abnormal gallbladder physiology (HP:0012438)2.15804875
67Cholecystitis (HP:0001082)2.15804875
68Megaloblastic anemia (HP:0001889)2.10891354
69Progressive external ophthalmoplegia (HP:0000590)2.10133751
70Agnosia (HP:0010524)2.08974003
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.08057052
72Rib fusion (HP:0000902)2.06972767
73Abnormality of the ileum (HP:0001549)2.06580711
74Secondary amenorrhea (HP:0000869)2.05890278
75Glioma (HP:0009733)2.05667551
76Truncus arteriosus (HP:0001660)2.05314003
77Meckel diverticulum (HP:0002245)2.05131260
78Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03840562
79Increased nuchal translucency (HP:0010880)2.02012475
80Impulsivity (HP:0100710)2.01772290
81Squamous cell carcinoma (HP:0002860)2.01728070
82Poikiloderma (HP:0001029)2.01217283
83Muscle fibrillation (HP:0010546)1.99889653
84Renal duplication (HP:0000075)1.99718591
85CNS hypomyelination (HP:0003429)1.98796983
86Unilateral renal agenesis (HP:0000122)1.98664589
87Rhabdomyolysis (HP:0003201)1.98134491
88Hypokinesia (HP:0002375)1.98073173
89Tracheoesophageal fistula (HP:0002575)1.96134941
90Cellular immunodeficiency (HP:0005374)1.95844097
91Abnormality of the umbilical cord (HP:0010881)1.95613595
92Deep palmar crease (HP:0006191)1.95532534
93Tongue fasciculations (HP:0001308)1.95415166
94Patellar dislocation (HP:0002999)1.94329240
95Dysmetric saccades (HP:0000641)1.94115902
96Slender long bone (HP:0003100)1.93478390
97Back pain (HP:0003418)1.92760254
98Premature skin wrinkling (HP:0100678)1.92642724
99Neoplasm of striated muscle (HP:0009728)1.92119798
100Sparse eyelashes (HP:0000653)1.91877141
101Abnormality of the preputium (HP:0100587)1.91775732
102Myopathic facies (HP:0002058)1.91734890
103Short humerus (HP:0005792)1.88598876
104Atresia of the external auditory canal (HP:0000413)1.87791817
105Personality changes (HP:0000751)1.87362117
106Abnormality of glycolysis (HP:0004366)1.86425912
107Increased serum pyruvate (HP:0003542)1.86425912
108Generalized amyotrophy (HP:0003700)1.84591110
109Supernumerary spleens (HP:0009799)1.83610431
110Spastic diplegia (HP:0001264)1.83544674
111Abnormality of pyrimidine metabolism (HP:0004353)1.83355036
112Centrally nucleated skeletal muscle fibers (HP:0003687)1.81920705
113Neoplasm of the oral cavity (HP:0100649)1.81127271
114Difficulty climbing stairs (HP:0003551)1.80782775
115Pseudobulbar signs (HP:0002200)1.80091551
116Missing ribs (HP:0000921)1.79688983
117Emotional lability (HP:0000712)1.79085515
118Self-mutilation (HP:0000742)1.77617912
119Abnormality of the motor neurons (HP:0002450)1.76989893
120Abnormal neuron morphology (HP:0012757)1.76989893
121Ureteral duplication (HP:0000073)1.76983866
122Bone marrow hypocellularity (HP:0005528)1.76908381
12311 pairs of ribs (HP:0000878)1.76680209
124Asymmetry of the thorax (HP:0001555)1.76470347
125Testicular atrophy (HP:0000029)1.75814905
126Entropion (HP:0000621)1.75081438
127Elbow flexion contracture (HP:0002987)1.73022182
128Abnormality of the distal phalanges of the toes (HP:0010182)1.72017517
129Hypoplasia of the radius (HP:0002984)1.71900560
130Postnatal microcephaly (HP:0005484)1.71397245
131Abnormality of the thoracic spine (HP:0100711)1.71226929
132Ragged-red muscle fibers (HP:0003200)1.70976482
133Duplication of thumb phalanx (HP:0009942)1.70687001
134Single umbilical artery (HP:0001195)1.70087496
135Abnormality of the fetal cardiovascular system (HP:0010948)1.70087496
136Abnormal umbilical cord blood vessels (HP:0011403)1.70087496
137Sparse lateral eyebrow (HP:0005338)1.68712780
138Abnormality of the labia minora (HP:0012880)1.68143265
139Fasciculations (HP:0002380)1.68122555
140Hyperthyroidism (HP:0000836)1.68112376
141Chromosomal breakage induced by crosslinking agents (HP:0003221)1.68092849
142Disproportionate tall stature (HP:0001519)1.67907510
143Hypergonadotropic hypogonadism (HP:0000815)1.67091069
144Unsteady gait (HP:0002317)1.66998588
145Overlapping toe (HP:0001845)1.66942692
146Triphalangeal thumb (HP:0001199)1.66216098
147Aplasia/Hypoplasia involving the musculature (HP:0001460)1.65372090
148Preauricular skin tag (HP:0000384)1.64681084
149Microvesicular hepatic steatosis (HP:0001414)1.64318774
150Abnormality of the tricuspid valve (HP:0001702)1.64303543
151CNS demyelination (HP:0007305)1.64126412
152Nonimmune hydrops fetalis (HP:0001790)1.63891043
153Nasolacrimal duct obstruction (HP:0000579)1.63721983
154Glossoptosis (HP:0000162)1.63517819
155Upper limb amyotrophy (HP:0009129)1.63351882
156Distal upper limb amyotrophy (HP:0007149)1.63351882
157Pancytopenia (HP:0001876)1.63349885
158Abnormality of subcutaneous fat tissue (HP:0001001)1.62436818
159Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.62135243
160Absent epiphyses (HP:0010577)1.62135243
161Pointed chin (HP:0000307)1.58223202

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.29424396
2WEE13.87342535
3SMG13.84080092
4IRAK33.66849657
5TESK23.19872416
6CDC72.82810121
7EPHA22.69694753
8NEK12.61388727
9NME22.59098381
10NEK22.39899820
11EIF2AK12.38212748
12TTK2.15507834
13VRK22.13634353
14MAP3K112.09189269
15RPS6KB22.01309512
16TSSK61.99433775
17SIK11.90497281
18STK161.89428177
19CDK71.76634729
20KDR1.74248936
21SCYL21.73484970
22PLK11.72443110
23DYRK31.71660383
24EEF2K1.71105734
25PKN21.63846855
26MAP3K101.59504470
27SRPK11.58726296
28TLK11.58335485
29PRPF4B1.57541841
30MAPKAPK31.55381998
31BCKDK1.52658154
32AURKA1.52433178
33MAP3K81.50298539
34PLK41.49213479
35ARAF1.47009985
36PIM21.46040261
37PAK41.45736001
38TRIB31.37443958
39CDK81.35047928
40LATS21.34952747
41AURKB1.32958554
42TESK11.30847222
43PBK1.26595348
44MST1R1.25280416
45RPS6KA41.23834508
46CDK121.22505474
47EIF2AK31.20684554
48ACVR1B1.19797235
49ATR1.17558578
50CDK41.17039867
51CHEK21.16970793
52BRSK21.14580598
53VRK11.10002132
54STK101.08727117
55PASK0.96992441
56PAK10.95953802
57CHEK10.95860743
58ALK0.95704499
59ICK0.95383172
60BRSK10.93939367
61LRRK20.93211423
62IRAK20.90506790
63MAPK110.89367764
64PRKCI0.85109860
65TAOK20.84226649
66FLT30.78652098
67MKNK10.78064365
68TAOK10.77794631
69LMTK20.77426954
70CDK20.75650621
71MAP2K30.74455545
72AKT20.71912589
73PLK30.71717960
74CSNK2A20.69154760
75NME10.68554295
76MAP3K90.67157384
77LIMK10.66718518
78MTOR0.66174129
79PNCK0.65202534
80CDK190.65048094
81FGFR40.63410328
82MAP4K10.62993049
83BRAF0.62609307
84PIM10.62379353
85GRK60.62175509
86STK40.60220002
87ILK0.59828742
88TGFBR10.57463552
89CSNK2A10.57030806
90PTK60.53919777
91DAPK10.53793087
92DAPK30.53086420
93MAP2K20.52023944
94ZAK0.51946816
95TTN0.50626170
96ATM0.49795049
97PRKG20.49072790
98PTK20.48848447
99CSNK1E0.48088873
100CDK90.47145485
101MAP3K30.45348916
102IRAK10.44956473
103PAK20.44955133
104CLK10.44256106
105KSR20.43851903
106TAF10.43222511
107ERN10.43102761
108CDK10.41925409
109PDK30.41562893
110PDK40.41562893
111RPS6KA10.40625107
112RPS6KL10.40577790
113RPS6KC10.40577790
114ERBB40.39056730
115PDPK10.37231945
116MKNK20.37002175
117DYRK20.36177803
118MAPKAPK50.36158641
119IRAK40.35467118
120CAMK1D0.35292056
121CDK11A0.33295797
122BMX0.32957503
123CDK60.29238177
124MAP3K50.28759215
125RPS6KA50.27521025
126ABL20.26642937
127CCNB10.25002688
128CDK150.24955025
129RAF10.24510198
130FGFR10.23530839

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.81510801
2Ribosome_Homo sapiens_hsa030104.04882584
3Mismatch repair_Homo sapiens_hsa034304.04347211
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.71164423
5Proteasome_Homo sapiens_hsa030503.50727140
6Spliceosome_Homo sapiens_hsa030403.29450325
7RNA polymerase_Homo sapiens_hsa030203.15287426
8RNA transport_Homo sapiens_hsa030133.00967046
9Base excision repair_Homo sapiens_hsa034102.95496833
10One carbon pool by folate_Homo sapiens_hsa006702.93756924
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.91870411
12Nucleotide excision repair_Homo sapiens_hsa034202.59684600
13Homologous recombination_Homo sapiens_hsa034402.46976705
14Pyrimidine metabolism_Homo sapiens_hsa002402.45638033
15Cell cycle_Homo sapiens_hsa041102.16141037
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.81193883
17Biosynthesis of amino acids_Homo sapiens_hsa012301.77050475
18Fanconi anemia pathway_Homo sapiens_hsa034601.57108149
19Folate biosynthesis_Homo sapiens_hsa007901.54240300
20Sulfur relay system_Homo sapiens_hsa041221.53188355
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.51333125
22p53 signaling pathway_Homo sapiens_hsa041151.46816187
23RNA degradation_Homo sapiens_hsa030181.45076074
24mRNA surveillance pathway_Homo sapiens_hsa030151.42168810
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.36589216
26Pentose phosphate pathway_Homo sapiens_hsa000301.35773284
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.34368943
28Carbon metabolism_Homo sapiens_hsa012001.30689228
29Basal transcription factors_Homo sapiens_hsa030221.19956365
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15834548
31Purine metabolism_Homo sapiens_hsa002301.15613787
32Non-homologous end-joining_Homo sapiens_hsa034501.12179967
33Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06204375
34Selenocompound metabolism_Homo sapiens_hsa004501.03258655
35Parkinsons disease_Homo sapiens_hsa050120.99355918
36Huntingtons disease_Homo sapiens_hsa050160.96809329
37Epstein-Barr virus infection_Homo sapiens_hsa051690.96660774
38Fructose and mannose metabolism_Homo sapiens_hsa000510.95523389
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94381905
40Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92398807
41Drug metabolism - other enzymes_Homo sapiens_hsa009830.89407610
42Non-small cell lung cancer_Homo sapiens_hsa052230.88721780
43Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85413629
44Vitamin B6 metabolism_Homo sapiens_hsa007500.82305978
45Oocyte meiosis_Homo sapiens_hsa041140.78795660
46Oxidative phosphorylation_Homo sapiens_hsa001900.78196213
47Systemic lupus erythematosus_Homo sapiens_hsa053220.77613826
48Lysine degradation_Homo sapiens_hsa003100.76294077
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76245000
50Glutathione metabolism_Homo sapiens_hsa004800.76016272
51Pancreatic cancer_Homo sapiens_hsa052120.73637170
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.73122347
53Prion diseases_Homo sapiens_hsa050200.71168560
54Viral carcinogenesis_Homo sapiens_hsa052030.70250853
55Arginine and proline metabolism_Homo sapiens_hsa003300.69622751
56Arginine biosynthesis_Homo sapiens_hsa002200.68234560
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64538839
58Galactose metabolism_Homo sapiens_hsa000520.61559191
59Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60633597
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59857066
61VEGF signaling pathway_Homo sapiens_hsa043700.59677253
62Bladder cancer_Homo sapiens_hsa052190.59311708
63AMPK signaling pathway_Homo sapiens_hsa041520.58271218
64Thyroid cancer_Homo sapiens_hsa052160.57769077
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54901004
66HTLV-I infection_Homo sapiens_hsa051660.54875162
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54148938
68Endometrial cancer_Homo sapiens_hsa052130.53393262
69Central carbon metabolism in cancer_Homo sapiens_hsa052300.52256475
70Vibrio cholerae infection_Homo sapiens_hsa051100.51216716
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.50176629
72Other glycan degradation_Homo sapiens_hsa005110.50091477
73Insulin signaling pathway_Homo sapiens_hsa049100.49756044
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.46348927
75Hippo signaling pathway_Homo sapiens_hsa043900.46220146
76Glioma_Homo sapiens_hsa052140.45512880
77Antigen processing and presentation_Homo sapiens_hsa046120.45129966
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42994382
79Herpes simplex infection_Homo sapiens_hsa051680.42754812
80Basal cell carcinoma_Homo sapiens_hsa052170.42686577
81Pyruvate metabolism_Homo sapiens_hsa006200.41535538
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41477717
83Melanoma_Homo sapiens_hsa052180.40292632
84Hedgehog signaling pathway_Homo sapiens_hsa043400.40287139
85Fatty acid elongation_Homo sapiens_hsa000620.40261912
86Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40126423
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.39525274
88Metabolic pathways_Homo sapiens_hsa011000.38871739
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37950149
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37261931
91Cardiac muscle contraction_Homo sapiens_hsa042600.36895705
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35228351
93Small cell lung cancer_Homo sapiens_hsa052220.33344521
94HIF-1 signaling pathway_Homo sapiens_hsa040660.32614638
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31569515
96Notch signaling pathway_Homo sapiens_hsa043300.31549546
97Prostate cancer_Homo sapiens_hsa052150.31141162
98Hepatitis B_Homo sapiens_hsa051610.31097868
99Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.29592048
100ErbB signaling pathway_Homo sapiens_hsa040120.29210286
101MicroRNAs in cancer_Homo sapiens_hsa052060.28582111
102Alzheimers disease_Homo sapiens_hsa050100.28411515
103Shigellosis_Homo sapiens_hsa051310.28324894
104Apoptosis_Homo sapiens_hsa042100.26420969
105Legionellosis_Homo sapiens_hsa051340.26410305
106N-Glycan biosynthesis_Homo sapiens_hsa005100.24511981
107mTOR signaling pathway_Homo sapiens_hsa041500.24162650
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.21916098
109Acute myeloid leukemia_Homo sapiens_hsa052210.18965337
110Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.17098647
111Alcoholism_Homo sapiens_hsa050340.14687624
112TGF-beta signaling pathway_Homo sapiens_hsa043500.14201556
113Colorectal cancer_Homo sapiens_hsa052100.14076637
114Fat digestion and absorption_Homo sapiens_hsa049750.12826392
115Renin-angiotensin system_Homo sapiens_hsa046140.12240453
116Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.11016671
117Tight junction_Homo sapiens_hsa045300.10829797
118Chronic myeloid leukemia_Homo sapiens_hsa052200.07352388
119Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.07263863
120Pathways in cancer_Homo sapiens_hsa052000.07158681
121Viral myocarditis_Homo sapiens_hsa054160.06818919
122beta-Alanine metabolism_Homo sapiens_hsa004100.05848968
123Phenylalanine metabolism_Homo sapiens_hsa003600.05698187
124Primary immunodeficiency_Homo sapiens_hsa053400.04938324
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.04908072

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