TOMM20P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)6.73787151
2RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)6.73787151
3sulfur amino acid catabolic process (GO:0000098)6.11062536
4regulation of plasminogen activation (GO:0010755)5.31102576
5regulation of sequestering of triglyceride (GO:0010889)5.25400189
6glyoxylate metabolic process (GO:0046487)4.82810758
7purine nucleotide salvage (GO:0032261)4.68970261
8S-adenosylmethionine metabolic process (GO:0046500)4.64025049
9adenosine metabolic process (GO:0046085)4.61596474
10erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.46101573
11L-phenylalanine catabolic process (GO:0006559)4.46101573
12xenobiotic catabolic process (GO:0042178)4.35963519
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.31793630
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.31793630
15NADH dehydrogenase complex assembly (GO:0010257)4.31793630
16rRNA modification (GO:0000154)4.14895516
17regulation of triglyceride catabolic process (GO:0010896)4.13868686
18ATP synthesis coupled proton transport (GO:0015986)4.12500348
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.12500348
20homocysteine metabolic process (GO:0050667)4.03673009
21protein complex biogenesis (GO:0070271)4.01450070
22serine family amino acid catabolic process (GO:0009071)3.98055573
23mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.88880999
24rRNA methylation (GO:0031167)3.70668791
25positive regulation of lipoprotein lipase activity (GO:0051006)3.63061160
26positive regulation of triglyceride lipase activity (GO:0061365)3.63061160
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.62806938
28L-phenylalanine metabolic process (GO:0006558)3.62806938
29cysteine metabolic process (GO:0006534)3.61076296
30respiratory chain complex IV assembly (GO:0008535)3.57358805
31mature B cell differentiation involved in immune response (GO:0002313)3.48415442
32cellular ketone body metabolic process (GO:0046950)3.48113350
33folic acid-containing compound biosynthetic process (GO:0009396)3.47848683
34mitochondrial respiratory chain complex assembly (GO:0033108)3.45779790
35mannosylation (GO:0097502)3.44888773
36GPI anchor biosynthetic process (GO:0006506)3.44730972
37aldehyde catabolic process (GO:0046185)3.44554011
38mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.44488260
39protein-cofactor linkage (GO:0018065)3.42205071
40purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)3.38148244
41electron transport chain (GO:0022900)3.34637660
42respiratory electron transport chain (GO:0022904)3.31388652
43neutrophil activation involved in immune response (GO:0002283)3.31288485
44GPI anchor metabolic process (GO:0006505)3.28933265
45arginine metabolic process (GO:0006525)3.26650488
46platelet dense granule organization (GO:0060155)3.26624511
47tyrosine metabolic process (GO:0006570)3.19574313
48proteasome assembly (GO:0043248)3.14239918
49galactose catabolic process (GO:0019388)3.13453014
50L-serine metabolic process (GO:0006563)3.13012393
51ATP hydrolysis coupled proton transport (GO:0015991)3.10208946
52energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.10208946
53mitochondrial RNA metabolic process (GO:0000959)3.10172068
54ketone body metabolic process (GO:1902224)3.08708489
55negative regulation of mast cell activation (GO:0033004)3.06237162
56aromatic amino acid family catabolic process (GO:0009074)3.04728521
57mature B cell differentiation (GO:0002335)3.00878817
58tetrahydrofolate metabolic process (GO:0046653)2.99798169
59pteridine-containing compound biosynthetic process (GO:0042559)2.96105680
60cullin deneddylation (GO:0010388)2.93455939
61C-terminal protein lipidation (GO:0006501)2.92174947
62cytochrome complex assembly (GO:0017004)2.86742863
63preassembly of GPI anchor in ER membrane (GO:0016254)2.80960384
64nucleotide salvage (GO:0043173)2.80297755
65deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.79516200
66L-methionine salvage (GO:0071267)2.78377566
67L-methionine biosynthetic process (GO:0071265)2.78377566
68amino acid salvage (GO:0043102)2.78377566
69arginine catabolic process (GO:0006527)2.77149390
70negative regulation of acute inflammatory response (GO:0002674)2.77131553
71GTP biosynthetic process (GO:0006183)2.76498881
72purine-containing compound salvage (GO:0043101)2.75932472
73hydrogen ion transmembrane transport (GO:1902600)2.75309729
74organic cation transport (GO:0015695)2.74640961
75negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.73946898
76autophagic vacuole fusion (GO:0000046)2.72868110
77protein-chromophore linkage (GO:0018298)2.72798685
78L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.72366148
79alkaloid metabolic process (GO:0009820)2.70706307
80sulfur amino acid metabolic process (GO:0000096)2.68792136
81proton transport (GO:0015992)2.68756083
82inner mitochondrial membrane organization (GO:0007007)2.68670876
83inner ear receptor cell development (GO:0060119)2.65341348
84hydrogen transport (GO:0006818)2.64144916
85regulation of cellular amino acid metabolic process (GO:0006521)2.62916285
86serine family amino acid biosynthetic process (GO:0009070)2.62430086
87branched-chain amino acid catabolic process (GO:0009083)2.61343200
88methionine metabolic process (GO:0006555)2.60323716
89branched-chain amino acid metabolic process (GO:0009081)2.55903362
90sulfur amino acid biosynthetic process (GO:0000097)2.55609943
91nucleoside transmembrane transport (GO:1901642)2.54781062
92mast cell activation (GO:0045576)2.54255262
93cellular amino acid catabolic process (GO:0009063)2.53207230
94nitrogen cycle metabolic process (GO:0071941)2.52298760
95C-terminal protein amino acid modification (GO:0018410)2.50864804
96alpha-amino acid catabolic process (GO:1901606)2.50682786
97response to growth hormone (GO:0060416)2.49343299
98cytidine metabolic process (GO:0046087)2.49151741
99cytidine catabolic process (GO:0006216)2.49151741
100cytidine deamination (GO:0009972)2.49151741

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse7.05077354
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.17640800
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.52006721
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.16765539
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16532350
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.13467160
7EGR1_23403033_ChIP-Seq_LIVER_Mouse2.67048210
8NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.62527517
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60059455
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.56979274
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.46456271
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.42013233
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.25402261
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.22210407
15PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.04639163
16VDR_23849224_ChIP-Seq_CD4+_Human1.99915171
17FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.98182348
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.93042385
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.89314292
20ZNF274_21170338_ChIP-Seq_K562_Hela1.84164028
21VDR_22108803_ChIP-Seq_LS180_Human1.83265755
22HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.81761067
23ETS1_20019798_ChIP-Seq_JURKAT_Human1.67102833
24NCOR_22424771_ChIP-Seq_293T_Human1.63711081
25ELK1_19687146_ChIP-ChIP_HELA_Human1.62109565
26SRF_21415370_ChIP-Seq_HL-1_Mouse1.61450204
27PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.58654463
28TP53_22573176_ChIP-Seq_HFKS_Human1.58203326
29CIITA_25753668_ChIP-Seq_RAJI_Human1.57808035
30ERG_20517297_ChIP-Seq_VCAP_Human1.49682432
31NANOG_19829295_ChIP-Seq_ESCs_Human1.46613527
32SOX2_19829295_ChIP-Seq_ESCs_Human1.46613527
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.45997332
34FOXP3_21729870_ChIP-Seq_TREG_Human1.45521062
35IGF1R_20145208_ChIP-Seq_DFB_Human1.42321938
36TAF2_19829295_ChIP-Seq_ESCs_Human1.42023485
37ETV2_25802403_ChIP-Seq_MESCs_Mouse1.41596111
38STAT1_20625510_ChIP-Seq_HELA_Human1.38928888
39FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.35397920
40CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.32770297
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.32696287
42GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31706507
43GATA3_26560356_Chip-Seq_TH2_Human1.30042771
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.28096518
45RXR_22158963_ChIP-Seq_LIVER_Mouse1.27064454
46GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26725140
47AR_20517297_ChIP-Seq_VCAP_Human1.24014623
48FOXA1_27270436_Chip-Seq_PROSTATE_Human1.23508126
49FOXA1_25329375_ChIP-Seq_VCAP_Human1.23508126
50FOXH1_21741376_ChIP-Seq_EPCs_Human1.23040125
51HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19715460
52CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.19353037
53EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.19160567
54EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.17702432
55BCAT_22108803_ChIP-Seq_LS180_Human1.16882319
56GATA3_21878914_ChIP-Seq_MCF-7_Human1.15176753
57BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.14085026
58GATA3_26560356_Chip-Seq_TH1_Human1.12351901
59CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.12035964
60FOXH1_21741376_ChIP-Seq_ESCs_Human1.11689562
61IRF1_19129219_ChIP-ChIP_H3396_Human1.11621926
62DCP1A_22483619_ChIP-Seq_HELA_Human1.07892557
63ERA_21632823_ChIP-Seq_H3396_Human1.07546830
64CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.06767368
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04767831
66GATA6_21074721_ChIP-Seq_CACO-2_Human1.04512489
67AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04283337
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.04065867
69MYC_18555785_ChIP-Seq_MESCs_Mouse1.01903180
70CBP_20019798_ChIP-Seq_JUKART_Human1.01888121
71IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01888121
72HTT_18923047_ChIP-ChIP_STHdh_Human1.00272041
73CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99946621
74FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99246014
75CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98951956
76MYC_18358816_ChIP-ChIP_MESCs_Mouse0.98506210
77SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97902027
78E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96894119
79POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.96624725
80ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96565073
81SOX2_22085726_ChIP-Seq_NPCs_Mouse0.96544017
82P300_27268052_Chip-Seq_Bcells_Human0.96418636
83KAP1_22055183_ChIP-Seq_ESCs_Mouse0.95390941
84RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95224228
85EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.94853558
86GABP_19822575_ChIP-Seq_HepG2_Human0.94797238
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.94224417
88NANOG_20526341_ChIP-Seq_ESCs_Human0.93870864
89CEBPB_22108803_ChIP-Seq_LS180_Human0.92521663
90PHF8_20622853_ChIP-Seq_HELA_Human0.91973056
91SOX2_21211035_ChIP-Seq_LN229_Human0.91648487
92GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90953064
93RBPJ_21746931_ChIP-Seq_IB4_Human0.90707046
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.89828391
95SPI1_23547873_ChIP-Seq_NB4_Human0.89755545
96OCT4_20526341_ChIP-Seq_ESCs_Human0.89343214
97MYC_19829295_ChIP-Seq_ESCs_Human0.88779008
98CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.88540304
99KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88378911
100IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88313560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system6.74316917
2MP0005360_urolithiasis4.85051784
3MP0002139_abnormal_hepatobiliary_system3.35265973
4MP0003806_abnormal_nucleotide_metabolis3.34339141
5MP0005645_abnormal_hypothalamus_physiol3.33124041
6MP0005646_abnormal_pituitary_gland3.32896464
7MP0009697_abnormal_copulation3.24666887
8MP0005670_abnormal_white_adipose3.13664809
9MP0008875_abnormal_xenobiotic_pharmacok3.01889364
10MP0005085_abnormal_gallbladder_physiolo2.88351977
11MP0003724_increased_susceptibility_to2.76313106
12MP0000516_abnormal_urinary_system2.44377490
13MP0005367_renal/urinary_system_phenotyp2.44377490
14MP0008995_early_reproductive_senescence2.41215481
15MP0001835_abnormal_antigen_presentation2.14489657
16MP0000372_irregular_coat_pigmentation2.14423963
17MP0005671_abnormal_response_to2.00998084
18MP0005332_abnormal_amino_acid1.96493857
19MP0001764_abnormal_homeostasis1.91073518
20MP0003186_abnormal_redox_activity1.86894264
21MP0002736_abnormal_nociception_after1.83079140
22MP0005365_abnormal_bile_salt1.81761685
23MP0003868_abnormal_feces_composition1.80975718
24MP0003252_abnormal_bile_duct1.78841229
25MP0002876_abnormal_thyroid_physiology1.71893549
26MP0004147_increased_porphyrin_level1.71223723
27MP0002166_altered_tumor_susceptibility1.67413888
28MP0003880_abnormal_central_pattern1.56036554
29MP0006072_abnormal_retinal_apoptosis1.49400835
30MP0003183_abnormal_peptide_metabolism1.48816739
31MP0009785_altered_susceptibility_to1.45730430
32MP0005075_abnormal_melanosome_morpholog1.43359255
33MP0003786_premature_aging1.41917136
34MP0009764_decreased_sensitivity_to1.37701079
35MP0001968_abnormal_touch/_nociception1.37341606
36MP0000013_abnormal_adipose_tissue1.37006743
37MP0002006_tumorigenesis1.35998807
38MP0002938_white_spotting1.33519431
39MP0005084_abnormal_gallbladder_morpholo1.31995041
40MP0003638_abnormal_response/metabolism_1.31828287
41MP0001905_abnormal_dopamine_level1.30153999
42MP0009643_abnormal_urine_homeostasis1.26585491
43MP0001800_abnormal_humoral_immune1.25292398
44MP0002735_abnormal_chemical_nociception1.21272252
45MP0009333_abnormal_splenocyte_physiolog1.19905750
46MP0003195_calcinosis1.19130848
47MP0003878_abnormal_ear_physiology1.18422671
48MP0005377_hearing/vestibular/ear_phenot1.18422671
49MP0002837_dystrophic_cardiac_calcinosis1.18229400
50MP0005083_abnormal_biliary_tract1.16358058
51MP0005551_abnormal_eye_electrophysiolog1.15657216
52MP0002822_catalepsy1.14072204
53MP0008872_abnormal_physiological_respon1.14004265
54MP0006054_spinal_hemorrhage1.12690927
55MP0004885_abnormal_endolymph1.08665776
56MP0005636_abnormal_mineral_homeostasis1.05985340
57MP0003567_abnormal_fetal_cardiomyocyte1.01430878
58MP0004043_abnormal_pH_regulation0.97343646
59MP0002148_abnormal_hypersensitivity_rea0.96535951
60MP0001986_abnormal_taste_sensitivity0.93886319
61MP0002095_abnormal_skin_pigmentation0.93543414
62MP0005000_abnormal_immune_tolerance0.92052921
63MP0005253_abnormal_eye_physiology0.90972424
64MP0009745_abnormal_behavioral_response0.90451647
65MP0006036_abnormal_mitochondrial_physio0.85080015
66MP0002723_abnormal_immune_serum0.84855664
67MP0005167_abnormal_blood-brain_barrier0.84442603
68MP0005584_abnormal_enzyme/coenzyme_acti0.82759521
69MP0002452_abnormal_antigen_presenting0.80438906
70MP0003866_abnormal_defecation0.79324761
71MP0008469_abnormal_protein_level0.77027861
72MP0010329_abnormal_lipoprotein_level0.74325381
73MP0002132_abnormal_respiratory_system0.72657422
74MP0001845_abnormal_inflammatory_respons0.71305438
75MP0002734_abnormal_mechanical_nocicepti0.70501703
76MP0005408_hypopigmentation0.70320600
77MP0000613_abnormal_salivary_gland0.69513900
78MP0009379_abnormal_foot_pigmentation0.69031023
79MP0006082_CNS_inflammation0.68999489
80MP0002396_abnormal_hematopoietic_system0.67981104
81MP0005319_abnormal_enzyme/_coenzyme0.67489143
82MP0006276_abnormal_autonomic_nervous0.66488055
83MP0003121_genomic_imprinting0.66450706
84MP0009763_increased_sensitivity_to0.66257672
85MP0002069_abnormal_eating/drinking_beha0.66193655
86MP0004019_abnormal_vitamin_homeostasis0.64569106
87MP0000371_diluted_coat_color0.64347875
88MP0001819_abnormal_immune_cell0.63793031
89MP0002420_abnormal_adaptive_immunity0.63595369
90MP0003787_abnormal_imprinting0.61933027
91MP0001756_abnormal_urination0.60786325
92MP0005376_homeostasis/metabolism_phenot0.59757540
93MP0005464_abnormal_platelet_physiology0.59647079
94MP0002419_abnormal_innate_immunity0.59353686
95MP0002118_abnormal_lipid_homeostasis0.58633566
96MP0001970_abnormal_pain_threshold0.57301447
97MP0005025_abnormal_response_to0.57160580
98MP0009642_abnormal_blood_homeostasis0.54169277
99MP0005266_abnormal_metabolism0.53587575
100MP0001944_abnormal_pancreas_morphology0.53256332

Predicted human phenotypes

RankGene SetZ-score
1Hyperalaninemia (HP:0003348)6.31001966
2Abnormality of pyruvate family amino acid metabolism (HP:0010915)6.31001966
3Abnormality of alanine metabolism (HP:0010916)6.31001966
4Decreased electroretinogram (ERG) amplitude (HP:0000654)4.08839080
5Generalized aminoaciduria (HP:0002909)3.83844108
6Acute necrotizing encephalopathy (HP:0006965)3.75847236
7Hepatocellular necrosis (HP:0001404)3.73844089
8Mitochondrial inheritance (HP:0001427)3.62294942
9Elevated erythrocyte sedimentation rate (HP:0003565)3.60373599
10Acute encephalopathy (HP:0006846)3.41119785
11Abnormality of aromatic amino acid family metabolism (HP:0004338)3.35142342
12Constricted visual fields (HP:0001133)3.29731604
13Progressive macrocephaly (HP:0004481)3.23404651
14Abnormal mitochondria in muscle tissue (HP:0008316)3.21432465
15Hepatic necrosis (HP:0002605)3.16787396
16Aplastic anemia (HP:0001915)3.13044672
17Increased CSF lactate (HP:0002490)3.12765672
18Esophageal varix (HP:0002040)2.94874409
19Pulmonary embolism (HP:0002204)2.91826171
20Abnormality of serum amino acid levels (HP:0003112)2.91809617
21Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.89627031
22Cerebral edema (HP:0002181)2.88250484
23Short tibia (HP:0005736)2.87026490
24Congenital sensorineural hearing impairment (HP:0008527)2.83856340
25Hypothermia (HP:0002045)2.81175355
26Abnormality of pyrimidine metabolism (HP:0004353)2.75755279
27Lactic acidosis (HP:0003128)2.70886847
28Fatigue (HP:0012378)2.67949691
29Abnormality of the prostate (HP:0008775)2.66091859
30Hyperphosphaturia (HP:0003109)2.65112972
31Reduced antithrombin III activity (HP:0001976)2.57185974
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.54941560
33Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.54693547
34Abnormality of sulfur amino acid metabolism (HP:0004339)2.52242294
35Deep venous thrombosis (HP:0002625)2.51480140
36Abnormality of monocarboxylic acid metabolism (HP:0010996)2.49976556
37Thrombophlebitis (HP:0004418)2.49798180
38Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46535130
39Increased serum lactate (HP:0002151)2.42631180
40Type I transferrin isoform profile (HP:0003642)2.42045646
41Gastrointestinal infarctions (HP:0005244)2.41125242
42Abnormality of methionine metabolism (HP:0010901)2.37659697
43Bile duct proliferation (HP:0001408)2.37545785
44Abnormal biliary tract physiology (HP:0012439)2.37545785
45Abnormality of urine glucose concentration (HP:0011016)2.37130304
46Glycosuria (HP:0003076)2.37130304
47Pigmentary retinal degeneration (HP:0001146)2.36912732
483-Methylglutaconic aciduria (HP:0003535)2.36454418
49Large eyes (HP:0001090)2.35835953
50Oligomenorrhea (HP:0000876)2.34952078
51Poor speech (HP:0002465)2.29788468
52Ureteral obstruction (HP:0006000)2.27099082
53Renal Fanconi syndrome (HP:0001994)2.25864161
54Spontaneous hematomas (HP:0007420)2.22380713
55Chronic hepatic failure (HP:0100626)2.21639110
56Ileus (HP:0002595)2.20562189
57Abnormality of aspartate family amino acid metabolism (HP:0010899)2.20460236
58Peritonitis (HP:0002586)2.19147253
59Abolished electroretinogram (ERG) (HP:0000550)2.17878142
60Petechiae (HP:0000967)2.17350560
61Alveolar cell carcinoma (HP:0006519)2.16250977
62White forelock (HP:0002211)2.15590520
63Exertional dyspnea (HP:0002875)2.15157097
64Anorexia (HP:0002039)2.13999758
65Myocardial infarction (HP:0001658)2.12306674
66Pancreatitis (HP:0001733)2.11701622
67Attenuation of retinal blood vessels (HP:0007843)2.11019280
68Congenital stationary night blindness (HP:0007642)2.08763750
69Abnormality of dental color (HP:0011073)2.05713920
70Metabolic acidosis (HP:0001942)2.05083431
71Ureteral stenosis (HP:0000071)2.04809971
72Conjugated hyperbilirubinemia (HP:0002908)2.04469165
73Lethargy (HP:0001254)2.03933809
74Abnormality of homocysteine metabolism (HP:0010919)2.02201395
75Homocystinuria (HP:0002156)2.02201395
76Stenosis of the external auditory canal (HP:0000402)2.02126409
77Hypoproteinemia (HP:0003075)1.99306707
78Spontaneous abortion (HP:0005268)1.99086745
79Congenital, generalized hypertrichosis (HP:0004540)1.98570751
80Gangrene (HP:0100758)1.97226915
81Dyskinesia (HP:0100660)1.93599192
82Increased hepatocellular lipid droplets (HP:0006565)1.92495320
83Heterochromia iridis (HP:0001100)1.92140109
84Intrahepatic cholestasis (HP:0001406)1.88837368
85Patchy hypopigmentation of hair (HP:0011365)1.88824417
86True hermaphroditism (HP:0010459)1.87596780
87CNS demyelination (HP:0007305)1.87494246
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.85984227
89Pancreatic cysts (HP:0001737)1.85734885
90Hypobetalipoproteinemia (HP:0003563)1.83647049
91Abnormal urine phosphate concentration (HP:0012599)1.81531230
92Portal hypertension (HP:0001409)1.80506951
93Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76904388
94Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.76904388
95Leukodystrophy (HP:0002415)1.76439448
96Abnormal albumin level (HP:0012116)1.76323982
97Hypoalbuminemia (HP:0003073)1.76323982
98Birth length less than 3rd percentile (HP:0003561)1.75282360
99Gingival bleeding (HP:0000225)1.74798718
100Chronic diarrhea (HP:0002028)1.71346595

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK195.43892130
2BMPR24.23002766
3MAP4K23.27196588
4MAP3K123.23845762
5BCKDK2.79690091
6NUAK12.59662452
7KDR2.49445875
8JAK32.34642014
9TLK12.21825127
10CCNB12.19181332
11OXSR12.02432660
12MYLK1.97498589
13DYRK21.88342432
14ERBB31.79054129
15TESK21.78570499
16TAOK31.69725135
17CSNK1G31.64047332
18VRK21.59379240
19MAP3K31.52127382
20TXK1.48000587
21LIMK11.46664574
22FGR1.45855923
23CSNK1G21.39744696
24ADRBK21.38685377
25CSNK1G11.34779322
26CSNK1A1L1.32661470
27GRK11.21749262
28MST41.19690793
29PAK41.19561469
30MATK1.15602973
31DAPK11.11814270
32IKBKB1.01680124
33ADRBK11.01402240
34ZAK0.92960267
35ACVR1B0.92882094
36BUB10.91952066
37PRKCE0.87353913
38CDK90.86848476
39PLK20.86050347
40MAPKAPK50.83418055
41SIK30.81584060
42FLT30.81485592
43VRK10.79409997
44FRK0.78761132
45SRPK10.77852490
46CSNK1A10.76403708
47MAP2K30.70427169
48MAP3K40.70216555
49FES0.69301866
50TEC0.68655742
51WNK40.68495979
52RPS6KB20.68002886
53DAPK30.67899089
54BTK0.66512533
55NTRK20.66426084
56LCK0.66110232
57WNK30.65637891
58INSRR0.65522508
59PHKG20.64257463
60PHKG10.64257463
61RPS6KA50.64209233
62PINK10.63951741
63BCR0.63444395
64NTRK10.63130940
65CDK11A0.62387767
66STK160.61511861
67LYN0.61500904
68ILK0.60873995
69CDK140.60522240
70NME20.59650971
71ABL10.59026451
72CSF1R0.57904670
73MUSK0.55645805
74PLK40.53032984
75TBK10.52759597
76GRK60.52572735
77CDK180.51774457
78CDK150.50710395
79JAK20.49439277
80TESK10.49040061
81SYK0.47060002
82IGF1R0.46182377
83ITK0.45746575
84CAMK2D0.45613476
85CLK10.45082557
86PRKCA0.42791307
87PRKCQ0.42109971
88OBSCN0.40754729
89PIM20.39965413
90PIK3CG0.39568085
91IKBKE0.38653583
92PAK10.38254338
93CAMK2G0.35161504
94PRKACA0.34217607
95CDK80.33708009
96CAMK2B0.33695299
97KIT0.33018569
98ATR0.31981625
99CAMK2A0.31377677
100INSR0.31285986

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053104.14737283
2Sulfur metabolism_Homo sapiens_hsa009203.09247599
3Allograft rejection_Homo sapiens_hsa053303.08783889
4Graft-versus-host disease_Homo sapiens_hsa053323.04122109
5Oxidative phosphorylation_Homo sapiens_hsa001902.95372156
6Autoimmune thyroid disease_Homo sapiens_hsa053202.94947803
7Type I diabetes mellitus_Homo sapiens_hsa049402.67255535
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.62826276
9Proteasome_Homo sapiens_hsa030502.60571365
10One carbon pool by folate_Homo sapiens_hsa006702.60425037
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.35074970
12Arginine biosynthesis_Homo sapiens_hsa002202.11542551
13Collecting duct acid secretion_Homo sapiens_hsa049662.09134521
14Parkinsons disease_Homo sapiens_hsa050122.07760417
15Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.02161901
16Rheumatoid arthritis_Homo sapiens_hsa053231.87507177
17Viral myocarditis_Homo sapiens_hsa054161.85833490
18Staphylococcus aureus infection_Homo sapiens_hsa051501.80131371
19Antigen processing and presentation_Homo sapiens_hsa046121.71451617
20Protein export_Homo sapiens_hsa030601.66233979
21Primary bile acid biosynthesis_Homo sapiens_hsa001201.65390874
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.51983166
23Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.46764270
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.44694592
25Chemical carcinogenesis_Homo sapiens_hsa052041.41960409
26Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41930725
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.40791635
28Linoleic acid metabolism_Homo sapiens_hsa005911.39468469
29Ribosome_Homo sapiens_hsa030101.33530133
30Alzheimers disease_Homo sapiens_hsa050101.32672806
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28686124
32RNA polymerase_Homo sapiens_hsa030201.24429097
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22233576
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19375261
35Nitrogen metabolism_Homo sapiens_hsa009101.18865330
36Huntingtons disease_Homo sapiens_hsa050161.17116656
37Retinol metabolism_Homo sapiens_hsa008301.16382932
38Systemic lupus erythematosus_Homo sapiens_hsa053221.12915207
39Peroxisome_Homo sapiens_hsa041461.06264322
40Leishmaniasis_Homo sapiens_hsa051401.05223147
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.05048971
42Propanoate metabolism_Homo sapiens_hsa006400.99924395
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.99152511
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99070448
45Butanoate metabolism_Homo sapiens_hsa006500.98095160
46Phenylalanine metabolism_Homo sapiens_hsa003600.94971994
47Cysteine and methionine metabolism_Homo sapiens_hsa002700.94187842
48Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92042162
49Complement and coagulation cascades_Homo sapiens_hsa046100.91053819
50Primary immunodeficiency_Homo sapiens_hsa053400.88038309
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87211401
52Pyruvate metabolism_Homo sapiens_hsa006200.82781241
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82386389
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76473476
55Vibrio cholerae infection_Homo sapiens_hsa051100.75677845
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74746625
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73951475
58beta-Alanine metabolism_Homo sapiens_hsa004100.70266343
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70194677
60Tyrosine metabolism_Homo sapiens_hsa003500.70112482
61Tryptophan metabolism_Homo sapiens_hsa003800.67576647
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67087532
63Phagosome_Homo sapiens_hsa041450.67049924
64Hematopoietic cell lineage_Homo sapiens_hsa046400.66680073
65Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66045464
66Cardiac muscle contraction_Homo sapiens_hsa042600.65551169
67Arachidonic acid metabolism_Homo sapiens_hsa005900.64149187
68Metabolic pathways_Homo sapiens_hsa011000.63131997
69Regulation of autophagy_Homo sapiens_hsa041400.60578408
70Sulfur relay system_Homo sapiens_hsa041220.59615318
71Caffeine metabolism_Homo sapiens_hsa002320.59551710
72Drug metabolism - other enzymes_Homo sapiens_hsa009830.58985235
73Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.58000512
74GABAergic synapse_Homo sapiens_hsa047270.57117501
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.55550430
76Biosynthesis of amino acids_Homo sapiens_hsa012300.53903954
77Arginine and proline metabolism_Homo sapiens_hsa003300.52071850
78Morphine addiction_Homo sapiens_hsa050320.51888479
79Glutathione metabolism_Homo sapiens_hsa004800.51049152
80Nicotine addiction_Homo sapiens_hsa050330.49611678
81Ether lipid metabolism_Homo sapiens_hsa005650.49170566
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45449068
83Synaptic vesicle cycle_Homo sapiens_hsa047210.44308201
84Selenocompound metabolism_Homo sapiens_hsa004500.44202569
85Galactose metabolism_Homo sapiens_hsa000520.43419237
86Pyrimidine metabolism_Homo sapiens_hsa002400.42933016
87Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42883165
88Fatty acid elongation_Homo sapiens_hsa000620.42091862
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42020726
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.40438182
91Purine metabolism_Homo sapiens_hsa002300.39191056
92Starch and sucrose metabolism_Homo sapiens_hsa005000.35338390
93Fat digestion and absorption_Homo sapiens_hsa049750.34103521
94Phototransduction_Homo sapiens_hsa047440.33524688
95Serotonergic synapse_Homo sapiens_hsa047260.32323615
96Vitamin digestion and absorption_Homo sapiens_hsa049770.30734931
97Olfactory transduction_Homo sapiens_hsa047400.29046604
98Basal transcription factors_Homo sapiens_hsa030220.28824715
99Carbon metabolism_Homo sapiens_hsa012000.27655392
100Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.27464787

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