TOMM20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.83133099
2regulation of translational termination (GO:0006449)4.78369976
3regulation of translational fidelity (GO:0006450)4.65710675
4ribosome assembly (GO:0042255)4.58297249
5purine nucleobase biosynthetic process (GO:0009113)4.22659738
6pore complex assembly (GO:0046931)4.20585159
7nucleobase biosynthetic process (GO:0046112)4.17187279
8regulation of short-term neuronal synaptic plasticity (GO:0048172)4.15945066
9ribosome biogenesis (GO:0042254)3.84218652
10DNA deamination (GO:0045006)3.82638167
11synaptic vesicle maturation (GO:0016188)3.82248258
12COPI coating of Golgi vesicle (GO:0048205)3.79019405
13Golgi transport vesicle coating (GO:0048200)3.79019405
14mitotic metaphase plate congression (GO:0007080)3.75419717
15maturation of SSU-rRNA (GO:0030490)3.72602641
16mitotic chromosome condensation (GO:0007076)3.71095147
17formation of translation preinitiation complex (GO:0001731)3.67728160
18peptidyl-arginine omega-N-methylation (GO:0035247)3.59930465
19DNA replication initiation (GO:0006270)3.57371370
20ribosomal large subunit biogenesis (GO:0042273)3.47664413
21histone arginine methylation (GO:0034969)3.46769628
22ribonucleoprotein complex biogenesis (GO:0022613)3.46094457
23regulation of RNA export from nucleus (GO:0046831)3.43230399
24DNA replication-dependent nucleosome organization (GO:0034723)3.38019077
25DNA replication-dependent nucleosome assembly (GO:0006335)3.38019077
26protein localization to kinetochore (GO:0034501)3.32795192
27locomotory exploration behavior (GO:0035641)3.31967411
28peptidyl-arginine methylation (GO:0018216)3.31872124
29peptidyl-arginine N-methylation (GO:0035246)3.31872124
30mitotic G1 DNA damage checkpoint (GO:0031571)3.30272657
31DNA unwinding involved in DNA replication (GO:0006268)3.28787309
32DNA replication checkpoint (GO:0000076)3.28447974
33translational initiation (GO:0006413)3.24986606
34establishment of integrated proviral latency (GO:0075713)3.24948869
35translational termination (GO:0006415)3.23610799
36paraxial mesoderm development (GO:0048339)3.21099443
37folic acid-containing compound biosynthetic process (GO:0009396)3.20353645
38positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.19283036
39spliceosomal snRNP assembly (GO:0000387)3.19096917
40folic acid metabolic process (GO:0046655)3.18266013
41proline biosynthetic process (GO:0006561)3.17782746
42regulation of nucleobase-containing compound transport (GO:0032239)3.16247654
43viral transcription (GO:0019083)3.15872582
44mitotic sister chromatid cohesion (GO:0007064)3.15789826
45heterochromatin organization (GO:0070828)3.15236404
46regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.14299671
47regulation of mitotic spindle organization (GO:0060236)3.14278718
48maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.13927505
49DNA strand elongation involved in DNA replication (GO:0006271)3.13039521
50protein complex localization (GO:0031503)3.11826670
51IMP biosynthetic process (GO:0006188)3.08860865
52mitotic nuclear envelope disassembly (GO:0007077)3.07031232
53translational elongation (GO:0006414)3.06340869
54membrane disassembly (GO:0030397)3.05472739
55nuclear envelope disassembly (GO:0051081)3.05472739
56DNA topological change (GO:0006265)3.05451503
57rRNA processing (GO:0006364)3.05021313
58positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.04277332
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.03286518
60protein retention in ER lumen (GO:0006621)3.02201625
61sister chromatid segregation (GO:0000819)3.00212514
62regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97708676
63rRNA metabolic process (GO:0016072)2.96437421
64pre-miRNA processing (GO:0031054)2.95801231
65positive regulation of synapse maturation (GO:0090129)2.94805483
66DNA strand elongation (GO:0022616)2.90683522
67metaphase plate congression (GO:0051310)2.90506910
68regulation of mammary gland epithelial cell proliferation (GO:0033599)2.89410807
69regulation of spindle organization (GO:0090224)2.88577439
70nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.87856380
71G1 DNA damage checkpoint (GO:0044783)2.85676776
72pseudouridine synthesis (GO:0001522)2.83780403
73glutamate secretion (GO:0014047)2.83142833
74RNA stabilization (GO:0043489)2.82412587
75mRNA stabilization (GO:0048255)2.82412587
76establishment of protein localization to mitochondrial membrane (GO:0090151)2.82317327
77ribosomal small subunit assembly (GO:0000028)2.81468609
78synaptic vesicle docking involved in exocytosis (GO:0016081)2.80859102
79protein localization to chromosome, centromeric region (GO:0071459)2.79090221
80mitotic G1/S transition checkpoint (GO:0044819)2.77818916
81chromatin remodeling at centromere (GO:0031055)2.76184800
82regulation of synaptic vesicle exocytosis (GO:2000300)2.75385203
83ribosomal small subunit biogenesis (GO:0042274)2.74674672
84positive regulation of dendritic spine morphogenesis (GO:0061003)2.74154750
85regulation of long-term neuronal synaptic plasticity (GO:0048169)2.73834268
86CENP-A containing nucleosome assembly (GO:0034080)2.73430231
87cellular protein complex disassembly (GO:0043624)2.73247859
88IMP metabolic process (GO:0046040)2.73214598
89protein export from nucleus (GO:0006611)2.73146551
90retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.72900772
91nuclear pore organization (GO:0006999)2.72326070
92synaptic vesicle exocytosis (GO:0016079)2.71738410
93DNA replication-independent nucleosome organization (GO:0034724)2.69725072
94DNA replication-independent nucleosome assembly (GO:0006336)2.69725072
95spliceosomal tri-snRNP complex assembly (GO:0000244)2.68486578
96regulation of centrosome cycle (GO:0046605)2.67917531
97protein-DNA complex disassembly (GO:0032986)2.67915035
98nucleosome disassembly (GO:0006337)2.67915035
99regulation of translational elongation (GO:0006448)2.65348825
100SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.64113908
101chaperone-mediated protein complex assembly (GO:0051131)2.61790784
102positive regulation of chromosome segregation (GO:0051984)2.61310350
103cotranslational protein targeting to membrane (GO:0006613)2.59701163
104histone exchange (GO:0043486)2.58507235
105protein targeting to ER (GO:0045047)2.56223188
106negative regulation of chromosome segregation (GO:0051985)2.56057382
107nucleobase-containing small molecule interconversion (GO:0015949)2.55972049
108rRNA modification (GO:0000154)2.55627727
109cellular protein complex localization (GO:0034629)2.54399554
110positive regulation of cell cycle checkpoint (GO:1901978)2.54045811
111regulation of posttranscriptional gene silencing (GO:0060147)2.53944165
112regulation of gene silencing by miRNA (GO:0060964)2.53944165
113regulation of gene silencing by RNA (GO:0060966)2.53944165
114regulation of chromosome segregation (GO:0051983)2.53594792
115mitotic spindle assembly checkpoint (GO:0007094)2.53136986
116mitotic sister chromatid segregation (GO:0000070)2.53028884
117establishment of protein localization to endoplasmic reticulum (GO:0072599)2.52917681
118DNA duplex unwinding (GO:0032508)2.52848700
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.52715512
120negative regulation of sister chromatid segregation (GO:0033046)2.52715512
121negative regulation of mitotic sister chromatid separation (GO:2000816)2.52715512
122negative regulation of mitotic sister chromatid segregation (GO:0033048)2.52715512
123spliceosomal complex assembly (GO:0000245)2.51738512
124regulation of neuronal synaptic plasticity (GO:0048168)2.51584509
125spindle checkpoint (GO:0031577)2.51301473
126layer formation in cerebral cortex (GO:0021819)2.50026906
127mitotic spindle checkpoint (GO:0071174)2.49902205
128nuclear envelope organization (GO:0006998)2.49363452
129telomere maintenance via semi-conservative replication (GO:0032201)2.49245322
130sodium ion export (GO:0071436)2.49159428
131macromolecular complex disassembly (GO:0032984)2.48550551
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.48517144
133protein complex disassembly (GO:0043241)2.48173740
134spindle assembly checkpoint (GO:0071173)2.47316592
135L-serine metabolic process (GO:0006563)2.46456488
136chromatin assembly or disassembly (GO:0006333)2.45904445
137negative regulation of RNA splicing (GO:0033119)2.44578739
138neuromuscular process controlling balance (GO:0050885)2.44184968
139histone H2B ubiquitination (GO:0033523)2.42980520
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.42891231
141viral life cycle (GO:0019058)2.39694273
142protein localization to endoplasmic reticulum (GO:0070972)2.39190702
143negative regulation of mRNA processing (GO:0050686)2.38935616
144establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.38663806
145mitochondrion transport along microtubule (GO:0047497)2.38663806
146DNA geometric change (GO:0032392)2.37761101
147tRNA aminoacylation for protein translation (GO:0006418)2.37335039
148cellular potassium ion homeostasis (GO:0030007)2.35624977
149vesicle coating (GO:0006901)2.35431793
150chromosome condensation (GO:0030261)2.35369983
151negative regulation of mRNA metabolic process (GO:1903312)2.33728955
152regulation of NFAT protein import into nucleus (GO:0051532)2.33097118
153cytoskeletal anchoring at plasma membrane (GO:0007016)2.31114975
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.30221481
155glutamine metabolic process (GO:0006541)2.28531334

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.47441871
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.78016602
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.93375395
4* MYC_19079543_ChIP-ChIP_MESCs_Mouse3.74802912
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.53490148
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05294405
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.93826650
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.89911105
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.89236192
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62144680
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.49798434
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48065066
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43429476
14* XRN2_22483619_ChIP-Seq_HELA_Human2.43371087
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.28520118
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26215508
17ZNF263_19887448_ChIP-Seq_K562_Human2.23436166
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.21565068
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.21349110
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.18010808
21AR_21909140_ChIP-Seq_LNCAP_Human2.15079653
22* CLOCK_20551151_ChIP-Seq_293T_Human2.04200901
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.02516308
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01688653
25* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.99122412
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.97380218
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.92819616
28POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92159854
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.91656779
30* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.90429195
31* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.85824015
32* GABP_19822575_ChIP-Seq_HepG2_Human1.82951793
33TTF2_22483619_ChIP-Seq_HELA_Human1.82744996
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81782109
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81605298
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.80645458
37* VDR_23849224_ChIP-Seq_CD4+_Human1.79400336
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.78414638
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.73225540
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71871379
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.70626555
42DCP1A_22483619_ChIP-Seq_HELA_Human1.67803977
43* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66719299
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.65567628
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.64195275
46ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60548011
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.59773657
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.56445983
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55600606
50* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54816083
51MYC_22102868_ChIP-Seq_BL_Human1.50078003
52DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49729066
53TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48249911
54* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.48115996
55POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44583313
56NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41818328
57* KDM5A_27292631_Chip-Seq_BREAST_Human1.41708868
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.40263713
59SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39756950
60SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.39240542
61* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.38261115
62FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38025485
63* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.37271690
64CHD1_26751641_Chip-Seq_LNCaP_Human1.36569335
65FOXP3_21729870_ChIP-Seq_TREG_Human1.35990431
66RARB_27405468_Chip-Seq_BRAIN_Mouse1.35925590
67* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.35098783
68CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35026139
69ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.34006254
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33946612
71TP63_17297297_ChIP-ChIP_HaCaT_Human1.33580015
72* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.33407755
73KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.29199759
74ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29009303
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28416328
76TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.26602503
77WT1_19549856_ChIP-ChIP_CCG9911_Human1.24834540
78SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23993339
79NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.22800413
80* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.22732171
81MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.19472764
82P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16736745
83* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.16418429
84ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15613529
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12437087
86TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11907461
87CIITA_25753668_ChIP-Seq_RAJI_Human1.11756406
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11350569
89CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09498702
90NANOG_21062744_ChIP-ChIP_HESCs_Human1.09448491
91FOXP1_21924763_ChIP-Seq_HESCs_Human1.07862222
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07568936
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.07390689
94OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07231027
95ZFP281_27345836_Chip-Seq_ESCs_Mouse1.06597421
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06537477
97CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06328364
98KDM2B_26808549_Chip-Seq_K562_Human1.06133924
99RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05888443
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03386232
101* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03134344
102SOX17_20123909_ChIP-Seq_XEN_Mouse1.02736103
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02570046
104* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01478369
105KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.00921570
106KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.00921570
107KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.00921570
108TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99354298
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98953252
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98554531
111RACK7_27058665_Chip-Seq_MCF-7_Human0.96610811
112SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94964657
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94418136
114SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.93604313
115ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93598759
116EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.92999149
117SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92832288
118SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92201805
119* TFEB_21752829_ChIP-Seq_HELA_Human0.91695350
120ATF3_27146783_Chip-Seq_COLON_Human0.91464890
121* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90778230
122* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.90499589
123KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90004514
124NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.89536375
125TCF3_18692474_ChIP-Seq_MESCs_Mouse0.89239509
126DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88572156
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.88484428
128TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.86753473
129REST_19997604_ChIP-ChIP_NEURONS_Mouse0.86513865

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.14272438
2MP0003693_abnormal_embryo_hatching3.80709341
3MP0004957_abnormal_blastocyst_morpholog3.69076473
4MP0003123_paternal_imprinting3.59860089
5MP0003111_abnormal_nucleus_morphology3.38161844
6MP0010094_abnormal_chromosome_stability2.74727857
7MP0003635_abnormal_synaptic_transmissio2.73289729
8MP0003077_abnormal_cell_cycle2.58556090
9MP0003880_abnormal_central_pattern2.50617480
10MP0002822_catalepsy2.35383765
11MP0002877_abnormal_melanocyte_morpholog2.27098914
12MP0004270_analgesia2.17402401
13MP0001730_embryonic_growth_arrest2.15161231
14MP0002063_abnormal_learning/memory/cond2.06967242
15MP0002009_preneoplasia2.04609085
16MP0009745_abnormal_behavioral_response1.94516641
17MP0003941_abnormal_skin_development1.90321729
18MP0002064_seizures1.85195573
19MP0008932_abnormal_embryonic_tissue1.84844630
20MP0010234_abnormal_vibrissa_follicle1.84412282
21MP0009046_muscle_twitch1.80066904
22MP0005423_abnormal_somatic_nervous1.77307342
23MP0003283_abnormal_digestive_organ1.76333971
24MP0010307_abnormal_tumor_latency1.76016450
25MP0009379_abnormal_foot_pigmentation1.75593059
26MP0000350_abnormal_cell_proliferation1.72202624
27MP0008058_abnormal_DNA_repair1.63712215
28MP0000566_synostosis1.54919299
29MP0003385_abnormal_body_wall1.51721449
30MP0004185_abnormal_adipocyte_glucose1.51454195
31MP0008007_abnormal_cellular_replicative1.51404572
32MP0010352_gastrointestinal_tract_polyps1.50465805
33MP0002653_abnormal_ependyma_morphology1.49384251
34MP0002084_abnormal_developmental_patter1.49151374
35MP0002734_abnormal_mechanical_nocicepti1.49096236
36MP0001697_abnormal_embryo_size1.48622570
37MP0008057_abnormal_DNA_replication1.48078419
38MP0002697_abnormal_eye_size1.45664116
39MP0004811_abnormal_neuron_physiology1.45081388
40MP0005409_darkened_coat_color1.43873040
41MP0001346_abnormal_lacrimal_gland1.42878437
42MP0002572_abnormal_emotion/affect_behav1.41174470
43MP0000537_abnormal_urethra_morphology1.40798456
44MP0002080_prenatal_lethality1.38912806
45MP0001188_hyperpigmentation1.37275727
46MP0003121_genomic_imprinting1.36361372
47MP0003119_abnormal_digestive_system1.35305751
48MP0002272_abnormal_nervous_system1.34656858
49MP0001672_abnormal_embryogenesis/_devel1.34593521
50MP0005380_embryogenesis_phenotype1.34593521
51MP0008877_abnormal_DNA_methylation1.32781901
52MP0001486_abnormal_startle_reflex1.31697245
53MP0002085_abnormal_embryonic_tissue1.31343865
54MP0004233_abnormal_muscle_weight1.31198149
55MP0003937_abnormal_limbs/digits/tail_de1.30061816
56MP0001968_abnormal_touch/_nociception1.28241138
57MP0003567_abnormal_fetal_cardiomyocyte1.26627756
58MP0004272_abnormal_basement_membrane1.25888897
59MP0003942_abnormal_urinary_system1.23034948
60MP0003315_abnormal_perineum_morphology1.21074076
61MP0001440_abnormal_grooming_behavior1.20640688
62MP0003115_abnormal_respiratory_system1.19881973
63MP0004885_abnormal_endolymph1.19709683
64MP0001529_abnormal_vocalization1.18800873
65MP0002909_abnormal_adrenal_gland1.16790509
66MP0000579_abnormal_nail_morphology1.15640450
67MP0003984_embryonic_growth_retardation1.12577485
68MP0002086_abnormal_extraembryonic_tissu1.11894128
69MP0000762_abnormal_tongue_morphology1.10978801
70MP0004197_abnormal_fetal_growth/weight/1.10778565
71MP0002088_abnormal_embryonic_growth/wei1.09600911
72MP0000358_abnormal_cell_content/1.09450423
73MP0003718_maternal_effect1.08083812
74MP0001299_abnormal_eye_distance/1.07934426
75MP0003329_amyloid_beta_deposits1.07790975
76MP0005623_abnormal_meninges_morphology1.06733176
77MP0002184_abnormal_innervation1.06725437
78MP0003786_premature_aging1.05138003
79MP0003861_abnormal_nervous_system1.02576035
80MP0005386_behavior/neurological_phenoty1.01559704
81MP0004924_abnormal_behavior1.01559704
82MP0002733_abnormal_thermal_nociception1.01487659
83MP0002796_impaired_skin_barrier0.98909283
84MP0001970_abnormal_pain_threshold0.98439352
85MP0004133_heterotaxia0.98431381
86MP0010030_abnormal_orbit_morphology0.97910170
87MP0003879_abnormal_hair_cell0.97715231
88MP0000955_abnormal_spinal_cord0.97620853
89MP0002152_abnormal_brain_morphology0.97422437
90MP0003935_abnormal_craniofacial_develop0.96870399
91MP0003705_abnormal_hypodermis_morpholog0.93929274
92MP0002066_abnormal_motor_capabilities/c0.93673558
93MP0000747_muscle_weakness0.93359273
94MP0002249_abnormal_larynx_morphology0.93311041
95MP0001177_atelectasis0.92456058
96MP0002081_perinatal_lethality0.92435843
97MP0003890_abnormal_embryonic-extraembry0.92363322
98MP0000778_abnormal_nervous_system0.91850890
99MP0003221_abnormal_cardiomyocyte_apopto0.91798044
100MP0009672_abnormal_birth_weight0.91564119
101MP0003566_abnormal_cell_adhesion0.91049265
102MP0000534_abnormal_ureter_morphology0.90718598
103MP0001661_extended_life_span0.90199531
104MP0000678_abnormal_parathyroid_gland0.89572322
105MP0001501_abnormal_sleep_pattern0.88566988
106MP0002882_abnormal_neuron_morphology0.87952808
107MP0005501_abnormal_skin_physiology0.87318708
108MP0002092_abnormal_eye_morphology0.87188437
109MP0006072_abnormal_retinal_apoptosis0.86907522
110MP0009697_abnormal_copulation0.86285309
111MP0008770_decreased_survivor_rate0.84556527
112MP0010630_abnormal_cardiac_muscle0.83947887
113MP0002111_abnormal_tail_morphology0.83907582
114MP0002114_abnormal_axial_skeleton0.83879466
115MP0001340_abnormal_eyelid_morphology0.83356643
116MP0003122_maternal_imprinting0.83215808
117MP0002160_abnormal_reproductive_system0.83185763
118MP0002067_abnormal_sensory_capabilities0.83144016
119MP0005666_abnormal_adipose_tissue0.82401484
120MP0002557_abnormal_social/conspecific_i0.82224395
121MP0004858_abnormal_nervous_system0.81895273
122MP0000313_abnormal_cell_death0.81768984
123MP0009053_abnormal_anal_canal0.81583564
124MP0005076_abnormal_cell_differentiation0.81167967
125MP0001286_abnormal_eye_development0.80225410
126MP0006035_abnormal_mitochondrial_morpho0.80205001
127MP0001915_intracranial_hemorrhage0.79096387
128MP0001849_ear_inflammation0.79035729
129MP0008569_lethality_at_weaning0.78218424
130MP0000733_abnormal_muscle_development0.77639429
131MP0005499_abnormal_olfactory_system0.77238817
132MP0005394_taste/olfaction_phenotype0.77238817
133MP0004782_abnormal_surfactant_physiolog0.77041521
134MP0005384_cellular_phenotype0.76078951
135MP0001145_abnormal_male_reproductive0.75023986
136MP0001485_abnormal_pinna_reflex0.74614121
137MP0003755_abnormal_palate_morphology0.74563572
138MP0001293_anophthalmia0.73123807
139MP0000428_abnormal_craniofacial_morphol0.72996050
140MP0002089_abnormal_postnatal_growth/wei0.71604975
141MP0005187_abnormal_penis_morphology0.70666414
142MP0009703_decreased_birth_body0.69341522
143MP0008872_abnormal_physiological_respon0.68600529
144MP0003787_abnormal_imprinting0.68156902
145MP0002210_abnormal_sex_determination0.66558064

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.33407852
2Birth length less than 3rd percentile (HP:0003561)4.00027473
3Cerebral hypomyelination (HP:0006808)3.84484267
4Focal motor seizures (HP:0011153)3.81568779
5Visual hallucinations (HP:0002367)3.37257732
6Ependymoma (HP:0002888)3.32803226
7Breast hypoplasia (HP:0003187)3.22336917
8Colon cancer (HP:0003003)3.09221447
9Abnormality of the labia minora (HP:0012880)3.07557864
10Abnormality of cells of the erythroid lineage (HP:0012130)3.03591048
11Insidious onset (HP:0003587)2.98355124
12Termporal pattern (HP:0011008)2.98355124
13Cortical dysplasia (HP:0002539)2.98223956
14Annular pancreas (HP:0001734)2.94373024
15Shoulder girdle muscle weakness (HP:0003547)2.92304957
16Abnormality of the lower motor neuron (HP:0002366)2.90537276
17CNS hypomyelination (HP:0003429)2.81544622
18Astrocytoma (HP:0009592)2.79000415
19Abnormality of the astrocytes (HP:0100707)2.79000415
20Focal seizures (HP:0007359)2.77051817
21Increased nuchal translucency (HP:0010880)2.72189112
22Abnormal number of erythroid precursors (HP:0012131)2.69990079
23Pelvic girdle muscle weakness (HP:0003749)2.64417596
24Ventricular fibrillation (HP:0001663)2.60805783
25Carpal bone hypoplasia (HP:0001498)2.58809503
26Hyperacusis (HP:0010780)2.56349969
27Postnatal microcephaly (HP:0005484)2.54997829
28Delusions (HP:0000746)2.52910432
29Asymmetry of the thorax (HP:0001555)2.49844059
30Progressive muscle weakness (HP:0003323)2.46313773
31Glioma (HP:0009733)2.45071463
32Dysmetric saccades (HP:0000641)2.43947111
33Unsteady gait (HP:0002317)2.40934982
34Rough bone trabeculation (HP:0100670)2.39680917
35Amyotrophic lateral sclerosis (HP:0007354)2.39350615
36Achilles tendon contracture (HP:0001771)2.37946546
37Ankyloglossia (HP:0010296)2.34688242
38Mutism (HP:0002300)2.32705433
39Atrophy/Degeneration involving motor neurons (HP:0007373)2.32176534
40Absence seizures (HP:0002121)2.32142977
41Overlapping toe (HP:0001845)2.31253340
42Abnormality of glycolysis (HP:0004366)2.30003151
43Abnormality of the musculature of the pelvis (HP:0001469)2.28271571
44Abnormality of the hip-girdle musculature (HP:0001445)2.28271571
45Pointed chin (HP:0000307)2.27494921
46Impaired vibration sensation in the lower limbs (HP:0002166)2.23179973
47Papilledema (HP:0001085)2.23090583
48Oral leukoplakia (HP:0002745)2.22231466
49Multiple enchondromatosis (HP:0005701)2.21138884
50Macrocytic anemia (HP:0001972)2.20607765
51Tetraplegia (HP:0002445)2.20446328
52Adenoma sebaceum (HP:0009720)2.19998235
53Angiofibromas (HP:0010615)2.19998235
54Urinary urgency (HP:0000012)2.19031954
55Rhabdomyosarcoma (HP:0002859)2.17988892
56Microretrognathia (HP:0000308)2.16361387
57Missing ribs (HP:0000921)2.15030519
58Hammertoe (HP:0001765)2.14140500
59Poor eye contact (HP:0000817)2.12776317
60Impaired smooth pursuit (HP:0007772)2.12728175
61Basal cell carcinoma (HP:0002671)2.12355551
62Abnormality of alanine metabolism (HP:0010916)2.11944400
63Hyperalaninemia (HP:0003348)2.11944400
64Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11944400
65Abnormality of cochlea (HP:0000375)2.10486878
66Overriding aorta (HP:0002623)2.08791609
67Renal duplication (HP:0000075)2.08062492
68Relative macrocephaly (HP:0004482)2.08023875
69Patellar aplasia (HP:0006443)2.06147171
70Ankle clonus (HP:0011448)2.06112159
71Dialeptic seizures (HP:0011146)2.05491972
72Cholecystitis (HP:0001082)2.02613724
73Abnormal gallbladder physiology (HP:0012438)2.02613724
74Abnormality of the anterior horn cell (HP:0006802)2.02285930
75Degeneration of anterior horn cells (HP:0002398)2.02285930
76Aplasia/Hypoplasia of the patella (HP:0006498)2.01504436
77Reticulocytopenia (HP:0001896)2.01377197
78Depression (HP:0000716)2.00169516
79Deep palmar crease (HP:0006191)2.00141048
80Medulloblastoma (HP:0002885)1.99402251
81Premature ovarian failure (HP:0008209)1.98378480
82Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.97964561
83Trismus (HP:0000211)1.96155726
84Truncus arteriosus (HP:0001660)1.95946310
85Abnormality of the Achilles tendon (HP:0005109)1.95451057
86Resting tremor (HP:0002322)1.95204323
87Abnormality of oral frenula (HP:0000190)1.95100891
88Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94628146
89Deviation of the thumb (HP:0009603)1.94322635
90Aplasia involving bones of the upper limbs (HP:0009823)1.93986886
91Aplasia of the phalanges of the hand (HP:0009802)1.93986886
92Aplasia involving bones of the extremities (HP:0009825)1.93986886
93Turricephaly (HP:0000262)1.89800765
94Impaired social interactions (HP:0000735)1.88218044
95Abnormal social behavior (HP:0012433)1.88218044
96Absent radius (HP:0003974)1.87767118
97Progressive external ophthalmoplegia (HP:0000590)1.87531023
98Proximal placement of thumb (HP:0009623)1.85082947
99Personality changes (HP:0000751)1.84368021
100Insomnia (HP:0100785)1.83365532
101Abnormality of ocular smooth pursuit (HP:0000617)1.83267004
102Arnold-Chiari malformation (HP:0002308)1.82511914
103Neoplasm of the pancreas (HP:0002894)1.82451464
104Breast aplasia (HP:0100783)1.82256873
105Neuroblastic tumors (HP:0004376)1.81803385
106Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.81803385
107Neuroblastoma (HP:0003006)1.81803385
108Primitive neuroectodermal tumor (HP:0030065)1.81803385
109Abnormal ventriculo-arterial connection (HP:0011563)1.81459304
110Transposition of the great arteries (HP:0001669)1.81459304
111Abnormal connection of the cardiac segments (HP:0011545)1.81459304
112Dysdiadochokinesis (HP:0002075)1.80038021
113Selective tooth agenesis (HP:0001592)1.79980162
114Bowel incontinence (HP:0002607)1.79977900
115Absent forearm bone (HP:0003953)1.79967019
116Aplasia involving forearm bones (HP:0009822)1.79967019
117Glossoptosis (HP:0000162)1.79542325
118Pheochromocytoma (HP:0002666)1.79518062
119Horseshoe kidney (HP:0000085)1.78787620
120Vertebral arch anomaly (HP:0008438)1.78060342
121Morphological abnormality of the inner ear (HP:0011390)1.77584018
122Back pain (HP:0003418)1.77405702
123Action tremor (HP:0002345)1.77233850
124Absent thumb (HP:0009777)1.76624999
125Bradykinesia (HP:0002067)1.76610980
126Deep philtrum (HP:0002002)1.76577416
127Urinary bladder sphincter dysfunction (HP:0002839)1.75667112
128Neoplasm of the peripheral nervous system (HP:0100007)1.75514447
129Abnormality of the calcaneus (HP:0008364)1.75091391
130Neoplasm of striated muscle (HP:0009728)1.74546985
131Increased serum pyruvate (HP:0003542)1.73976123
132Pseudobulbar signs (HP:0002200)1.73953296
133Elfin facies (HP:0004428)1.73278380
134Atonic seizures (HP:0010819)1.73099886
135Papillary thyroid carcinoma (HP:0002895)1.72330096
136Posterior subcapsular cataract (HP:0007787)1.71638393
137Facial hemangioma (HP:0000329)1.71541949
138Spinal muscular atrophy (HP:0007269)1.71530469
139Protrusio acetabuli (HP:0003179)1.71524709
140Atresia of the external auditory canal (HP:0000413)1.70987344
141Microvesicular hepatic steatosis (HP:0001414)1.70091372
142Abnormal large intestine physiology (HP:0012700)1.69744505
143Emotional lability (HP:0000712)1.69671394
144Short chin (HP:0000331)1.69129406
145Septate vagina (HP:0001153)1.68509085
146Obsessive-compulsive behavior (HP:0000722)1.66556472
147Duplication of thumb phalanx (HP:0009942)1.62091639
148Disproportionate tall stature (HP:0001519)1.61126032
149Abnormality of reticulocytes (HP:0004312)1.59834068
150Patellar dislocation (HP:0002999)1.59132669
151Abnormality of the distal phalanx of the thumb (HP:0009617)1.57931436
152Chromsome breakage (HP:0040012)1.56438685
153Hepatoblastoma (HP:0002884)1.56387813
154Chromosomal breakage induced by crosslinking agents (HP:0003221)1.54980447
155Broad palm (HP:0001169)1.54865076
156Gout (HP:0001997)1.54229241
157Shallow orbits (HP:0000586)1.54227804
158Abnormality of the salivary glands (HP:0010286)1.54091469
159Attention deficit hyperactivity disorder (HP:0007018)1.53409930
160Abnormal cartilage morphology (HP:0002763)1.53220547
161Lower limb amyotrophy (HP:0007210)1.50989104
162Unilateral renal agenesis (HP:0000122)1.50883882
163Alacrima (HP:0000522)1.50735108
164Breech presentation (HP:0001623)1.50592854
165Calcaneovalgus deformity (HP:0001848)1.50573138
166Heterotopia (HP:0002282)1.50114518
167Sparse lateral eyebrow (HP:0005338)1.49954412
168Coronal craniosynostosis (HP:0004440)1.49585094
169Peripheral hypomyelination (HP:0007182)1.48236254
170Impaired pain sensation (HP:0007328)1.47107633
171Abnormality of pain sensation (HP:0010832)1.47107633
172Reticulocytosis (HP:0001923)1.46190320
173Flat acetabular roof (HP:0003180)1.44826029
174Long palpebral fissure (HP:0000637)1.43110580
175Choanal stenosis (HP:0000452)1.42705391
176Orthostatic hypotension (HP:0001278)1.41797123
177Spinal cord lesions (HP:0100561)1.41717130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.55174974
2WEE13.33128222
3MAP3K93.25223434
4NEK13.16760330
5SCYL22.83799436
6EPHA42.74357771
7CDK122.64171956
8ICK2.56364683
9NTRK32.53549028
10EIF2AK12.41684086
11KSR22.32265799
12CDC72.13302007
13NEK22.06041945
14LATS21.83225592
15MAP3K101.79905955
16ALK1.78084300
17PAK61.72788843
18MINK11.68629894
19SMG11.66892117
20KSR11.66002801
21BRD41.64604268
22PKN21.64342198
23PDGFRA1.62695983
24CAMKK11.60795505
25BRSK11.58979223
26PNCK1.56599401
27SRPK11.55816572
28ARAF1.54628574
29PRKD31.50778945
30TTK1.50693163
31MARK11.49523897
32LATS11.48429199
33TESK21.48360357
34NME21.42440724
35EPHA21.42412694
36TSSK61.41843675
37PBK1.41453464
38STK381.40484321
39PRPF4B1.38238956
40PLK11.35292861
41CDK191.32610078
42RAF11.32569598
43DYRK31.24654192
44PLK31.22948430
45TLK11.16896575
46TAOK11.10432528
47AURKA1.10412391
48MAP3K41.06574823
49DAPK11.03972317
50BRSK21.02934296
51CDK61.02084290
52MAP3K81.00623112
53RIPK10.96370881
54ACVR1B0.95987122
55BRAF0.95921335
56NTRK10.95501383
57DAPK20.93927648
58CDK140.90796333
59CHEK20.90549116
60MTOR0.90289139
61NME10.90097147
62EIF2AK30.88547480
63CDK150.85597441
64AURKB0.84038714
65TYRO30.83698885
66TRIB30.82253520
67CDK180.81073826
68MAP3K110.80717083
69CDK11A0.79975916
70FGFR40.79478428
71CAMKK20.78222340
72RPS6KA40.77496157
73MAP3K20.77455258
74CLK10.76198611
75PINK10.73212688
76CHEK10.72823304
77VRK10.71559934
78PAK20.70504053
79CCNB10.69964231
80CDK50.69449773
81CSNK1E0.68988074
82MET0.68966736
83MAP3K130.68411338
84NTRK20.67103443
85PLK40.67005835
86FGFR10.66150569
87CDK20.66147370
88PTK20.64660461
89PAK40.64614131
90CDK40.63858388
91RPS6KB20.63638796
92MST1R0.63298393
93RET0.63224401
94CAMK1G0.62328012
95MAP2K40.62230092
96CDK70.60289773
97PRKCG0.60204641
98DMPK0.59078945
99PAK10.58744233
100ATR0.57498002
101PDK40.56636766
102PDK30.56636766
103SIK10.55247213
104WNK30.54805832
105MAPKAPK50.54706604
106ERBB40.52728548
107CAMK1D0.52349152
108STK110.52268317
109RPS6KB10.52244557
110ATM0.50492246
111MKNK20.50353607
112STK160.50279223
113IRAK30.49937794
114DAPK30.49695053
115UHMK10.48954077
116MAPK100.48573480
117BCR0.48418530
118NEK60.46169703
119PRKCI0.45380676
120MKNK10.45068985
121CSNK2A20.45019023
122FLT30.44688984
123MAP3K50.44426629
124PRKDC0.44014953
125AKT20.43210003
126EEF2K0.42755255
127CDK10.42636609
128PASK0.42416624
129CSNK1G20.42128695
130LRRK20.39891671
131MAP2K70.39825722
132AKT30.39166840
133TESK10.38076779
134DDR20.37059931

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.39522351
2DNA replication_Homo sapiens_hsa030303.01815748
3RNA transport_Homo sapiens_hsa030132.91080180
4Ribosome_Homo sapiens_hsa030102.63317666
5RNA polymerase_Homo sapiens_hsa030202.60398080
6Spliceosome_Homo sapiens_hsa030402.45650592
7Mismatch repair_Homo sapiens_hsa034302.41313073
8Oocyte meiosis_Homo sapiens_hsa041142.22805440
9Synaptic vesicle cycle_Homo sapiens_hsa047212.06599125
10Proteasome_Homo sapiens_hsa030502.03443537
11Cell cycle_Homo sapiens_hsa041101.89735547
12Vitamin B6 metabolism_Homo sapiens_hsa007501.86760709
13Long-term potentiation_Homo sapiens_hsa047201.85340827
14Nicotine addiction_Homo sapiens_hsa050331.84569528
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83605581
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.83070458
17Nucleotide excision repair_Homo sapiens_hsa034201.75638293
18Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68157281
19mRNA surveillance pathway_Homo sapiens_hsa030151.62683131
20Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61858294
21Pyrimidine metabolism_Homo sapiens_hsa002401.59289500
22Olfactory transduction_Homo sapiens_hsa047401.50757390
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50310164
24Amphetamine addiction_Homo sapiens_hsa050311.48391131
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.41343375
26GABAergic synapse_Homo sapiens_hsa047271.40325690
27Alcoholism_Homo sapiens_hsa050341.40123838
28Carbon metabolism_Homo sapiens_hsa012001.39836916
29Chronic myeloid leukemia_Homo sapiens_hsa052201.38355844
30Dopaminergic synapse_Homo sapiens_hsa047281.31381478
31Base excision repair_Homo sapiens_hsa034101.29032382
32mTOR signaling pathway_Homo sapiens_hsa041501.20168044
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18455726
34Circadian entrainment_Homo sapiens_hsa047131.18163294
35One carbon pool by folate_Homo sapiens_hsa006701.17386462
36Adherens junction_Homo sapiens_hsa045201.15749890
37Homologous recombination_Homo sapiens_hsa034401.15308555
38Pyruvate metabolism_Homo sapiens_hsa006201.13964861
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.08548998
40Purine metabolism_Homo sapiens_hsa002301.07990369
41Glutamatergic synapse_Homo sapiens_hsa047241.07602921
42Prion diseases_Homo sapiens_hsa050201.07326060
43Morphine addiction_Homo sapiens_hsa050321.06154424
44RNA degradation_Homo sapiens_hsa030181.05098659
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04960601
46Nitrogen metabolism_Homo sapiens_hsa009101.00956788
47Gap junction_Homo sapiens_hsa045401.00419925
48MicroRNAs in cancer_Homo sapiens_hsa052060.96983859
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96030375
50Arginine biosynthesis_Homo sapiens_hsa002200.95832867
51Glioma_Homo sapiens_hsa052140.95653701
52Systemic lupus erythematosus_Homo sapiens_hsa053220.92522908
53p53 signaling pathway_Homo sapiens_hsa041150.92385935
54Biosynthesis of amino acids_Homo sapiens_hsa012300.92357701
55Insulin signaling pathway_Homo sapiens_hsa049100.91629041
56Basal transcription factors_Homo sapiens_hsa030220.89818908
57Pancreatic cancer_Homo sapiens_hsa052120.88433531
58Thyroid cancer_Homo sapiens_hsa052160.87790199
59Cholinergic synapse_Homo sapiens_hsa047250.86024406
60Salivary secretion_Homo sapiens_hsa049700.85296852
61AMPK signaling pathway_Homo sapiens_hsa041520.84811339
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.84261133
63Oxytocin signaling pathway_Homo sapiens_hsa049210.84136641
64Cocaine addiction_Homo sapiens_hsa050300.83719190
65Gastric acid secretion_Homo sapiens_hsa049710.82461377
66Long-term depression_Homo sapiens_hsa047300.82346285
67Vibrio cholerae infection_Homo sapiens_hsa051100.79797659
68Lysine degradation_Homo sapiens_hsa003100.79786987
69Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79213084
70GnRH signaling pathway_Homo sapiens_hsa049120.78918477
71Estrogen signaling pathway_Homo sapiens_hsa049150.76192374
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.74762688
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74045192
74Central carbon metabolism in cancer_Homo sapiens_hsa052300.73957666
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.73804388
76Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73426237
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.73111866
78Hippo signaling pathway_Homo sapiens_hsa043900.72276823
79Insulin secretion_Homo sapiens_hsa049110.71872621
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.71676167
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71510101
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71243461
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70734254
84Thyroid hormone synthesis_Homo sapiens_hsa049180.70721565
85Fanconi anemia pathway_Homo sapiens_hsa034600.68919845
86Fructose and mannose metabolism_Homo sapiens_hsa000510.68462119
87Phototransduction_Homo sapiens_hsa047440.68083730
88Arginine and proline metabolism_Homo sapiens_hsa003300.67636086
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.66059576
90Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64821148
91Fatty acid biosynthesis_Homo sapiens_hsa000610.63911935
92Bladder cancer_Homo sapiens_hsa052190.62261394
93Non-small cell lung cancer_Homo sapiens_hsa052230.61253308
94Melanogenesis_Homo sapiens_hsa049160.61146534
95ErbB signaling pathway_Homo sapiens_hsa040120.61144967
96Cardiac muscle contraction_Homo sapiens_hsa042600.59812571
97Small cell lung cancer_Homo sapiens_hsa052220.59628337
98Colorectal cancer_Homo sapiens_hsa052100.59433669
99Proteoglycans in cancer_Homo sapiens_hsa052050.59169807
100Epstein-Barr virus infection_Homo sapiens_hsa051690.59146081
101Glucagon signaling pathway_Homo sapiens_hsa049220.58920819
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.58072342
103Prostate cancer_Homo sapiens_hsa052150.58030080
104N-Glycan biosynthesis_Homo sapiens_hsa005100.57586572
105Inositol phosphate metabolism_Homo sapiens_hsa005620.56800563
106Steroid biosynthesis_Homo sapiens_hsa001000.55871877
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.55667702
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.55079578
109VEGF signaling pathway_Homo sapiens_hsa043700.52771159
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52622681
111Choline metabolism in cancer_Homo sapiens_hsa052310.51650616
112Pentose phosphate pathway_Homo sapiens_hsa000300.51570945
113Calcium signaling pathway_Homo sapiens_hsa040200.51293505
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50975450
115Basal cell carcinoma_Homo sapiens_hsa052170.50541162
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50536742
117Viral carcinogenesis_Homo sapiens_hsa052030.50393368
118Endometrial cancer_Homo sapiens_hsa052130.49531760
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48642123
120Tight junction_Homo sapiens_hsa045300.48536325
121Hedgehog signaling pathway_Homo sapiens_hsa043400.48001363
122Melanoma_Homo sapiens_hsa052180.47792513
123HIF-1 signaling pathway_Homo sapiens_hsa040660.47524159
124Axon guidance_Homo sapiens_hsa043600.46889543
125Regulation of autophagy_Homo sapiens_hsa041400.45999851
126Renal cell carcinoma_Homo sapiens_hsa052110.45394302
127Wnt signaling pathway_Homo sapiens_hsa043100.44926094
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43033550
129Non-homologous end-joining_Homo sapiens_hsa034500.41476127
130cAMP signaling pathway_Homo sapiens_hsa040240.39966860
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.39706223
132Sulfur relay system_Homo sapiens_hsa041220.38993982
133Serotonergic synapse_Homo sapiens_hsa047260.38961062
134Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38568618
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38435368
136Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37823115
137Renin secretion_Homo sapiens_hsa049240.36789350
138Endocytosis_Homo sapiens_hsa041440.36616458
139Taste transduction_Homo sapiens_hsa047420.36370571

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