TNS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the tensin family. Tensin is a focal adhesion molecule that binds to actin filaments and participates in signaling pathways. This protein plays a role in regulating cell migration. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid transmembrane transport (GO:1902001)4.39464698
2carnitine shuttle (GO:0006853)4.34442538
3positive regulation of fatty acid beta-oxidation (GO:0032000)4.00084637
4glomerular basement membrane development (GO:0032836)3.92405416
5fatty acid beta-oxidation (GO:0006635)3.90392523
6regulation of sequestering of triglyceride (GO:0010889)3.90032590
7vascular endothelial growth factor signaling pathway (GO:0038084)3.85845573
8lysine metabolic process (GO:0006553)3.84623167
9lysine catabolic process (GO:0006554)3.84623167
10positive regulation of fatty acid oxidation (GO:0046321)3.79554748
11glomerular visceral epithelial cell development (GO:0072015)3.69125218
122-oxoglutarate metabolic process (GO:0006103)3.66284267
13regulation of fatty acid oxidation (GO:0046320)3.55410976
14valine metabolic process (GO:0006573)3.52482192
15alpha-linolenic acid metabolic process (GO:0036109)3.50556345
16fatty acid oxidation (GO:0019395)3.49177442
17biotin metabolic process (GO:0006768)3.45653750
18cardiac myofibril assembly (GO:0055003)3.43711701
19lipid oxidation (GO:0034440)3.40735188
20low-density lipoprotein particle clearance (GO:0034383)3.40345018
21cell migration involved in heart development (GO:0060973)3.39783901
22carnitine transmembrane transport (GO:1902603)3.36945783
23regulation of fatty acid beta-oxidation (GO:0031998)3.34116064
24fatty acid catabolic process (GO:0009062)3.33412978
25extracellular matrix assembly (GO:0085029)3.31607902
26L-phenylalanine metabolic process (GO:0006558)3.30689736
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.30689736
28plasma membrane repair (GO:0001778)3.28829393
29fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.27656866
30sulfur amino acid catabolic process (GO:0000098)3.27580771
31amino-acid betaine transport (GO:0015838)3.25737887
32carnitine transport (GO:0015879)3.25737887
33acetyl-CoA metabolic process (GO:0006084)3.23799689
34glomerular epithelial cell development (GO:0072310)3.23074152
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.22160569
36L-phenylalanine catabolic process (GO:0006559)3.22160569
37sarcomere organization (GO:0045214)3.21254962
38positive regulation of protein kinase C signaling (GO:0090037)3.19082468
39peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.18689761
40regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.17794547
41retina vasculature morphogenesis in camera-type eye (GO:0061299)3.15674001
42glyoxylate metabolic process (GO:0046487)3.14837686
43regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.13260468
44protein heterotrimerization (GO:0070208)3.12935410
45extracellular fibril organization (GO:0043206)3.09688714
46complement activation, alternative pathway (GO:0006957)3.05316844
47bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04341398
48tricarboxylic acid cycle (GO:0006099)3.03979914
49surfactant homeostasis (GO:0043129)3.02371556
50cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.01404975
51endothelial cell chemotaxis (GO:0035767)3.00868427
52regulation of triglyceride catabolic process (GO:0010896)2.98663708
53lymph vessel development (GO:0001945)2.98582978
54regulation of cholesterol homeostasis (GO:2000188)2.98411844
55semaphorin-plexin signaling pathway (GO:0071526)2.96634604
56epoxygenase P450 pathway (GO:0019373)2.95378734
57monocarboxylic acid catabolic process (GO:0072329)2.94550940
58negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.93860910
59tricarboxylic acid metabolic process (GO:0072350)2.93153601
60regulation of protein activation cascade (GO:2000257)2.90170485
61aspartate family amino acid catabolic process (GO:0009068)2.89262738
62amino-acid betaine metabolic process (GO:0006577)2.88982867
63branched-chain amino acid metabolic process (GO:0009081)2.88181869
64regulation of complement activation (GO:0030449)2.86857473
65short-chain fatty acid metabolic process (GO:0046459)2.86746559
66branched-chain amino acid catabolic process (GO:0009083)2.85671803
67basement membrane organization (GO:0071711)2.85387801
68myofibril assembly (GO:0030239)2.85340094
69heart trabecula formation (GO:0060347)2.85071640
70negative regulation of fibrinolysis (GO:0051918)2.84969502
71positive regulation of lipid catabolic process (GO:0050996)2.83609570
72regulation of p38MAPK cascade (GO:1900744)2.83335576
73atrioventricular valve morphogenesis (GO:0003181)2.82609710
74protein carboxylation (GO:0018214)2.82589740
75peptidyl-glutamic acid carboxylation (GO:0017187)2.82589740
76barbed-end actin filament capping (GO:0051016)2.82539112
77triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.82514608
78triglyceride homeostasis (GO:0070328)2.81027139
79acylglycerol homeostasis (GO:0055090)2.81027139
80carnitine metabolic process (GO:0009437)2.80956998
81positive regulation of p38MAPK cascade (GO:1900745)2.79664851
82insulin-like growth factor receptor signaling pathway (GO:0048009)2.79321915
83cell migration involved in sprouting angiogenesis (GO:0002042)2.76501638
84cell volume homeostasis (GO:0006884)2.75959513
85oxaloacetate metabolic process (GO:0006107)2.72779847
86positive regulation of receptor recycling (GO:0001921)2.71449308
87adherens junction assembly (GO:0034333)2.70529936
88kynurenine metabolic process (GO:0070189)2.69487756
89renal filtration (GO:0097205)2.68077933
90positive regulation of fatty acid metabolic process (GO:0045923)2.67860535
91lymphangiogenesis (GO:0001946)2.67669748
92fibril organization (GO:0097435)2.67442385
93ethanol oxidation (GO:0006069)2.67092706
94quaternary ammonium group transport (GO:0015697)2.66807549
95negative regulation of fatty acid biosynthetic process (GO:0045717)2.66435369
96venous blood vessel morphogenesis (GO:0048845)2.65172171
97cGMP-mediated signaling (GO:0019934)2.65158776
98homocysteine metabolic process (GO:0050667)2.64758676
99plasma lipoprotein particle clearance (GO:0034381)2.64398306
100aromatic amino acid family catabolic process (GO:0009074)2.63822619
101blood vessel endothelial cell migration (GO:0043534)2.63133939
102triglyceride catabolic process (GO:0019433)2.62848060
103negative regulation of fatty acid transport (GO:2000192)2.62310556
104cell-substrate junction assembly (GO:0007044)2.61733575
105cellular response to epinephrine stimulus (GO:0071872)2.60868904
106endocrine hormone secretion (GO:0060986)2.60779042
107vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.59561370
108regulation of cholesterol storage (GO:0010885)2.59139327
1094-hydroxyproline metabolic process (GO:0019471)2.58562258
110NADH metabolic process (GO:0006734)2.56771180
111apoptotic cell clearance (GO:0043277)2.56187761
112negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.56141385
113endothelium development (GO:0003158)2.55939197
114cell-substrate adherens junction assembly (GO:0007045)2.55542218
115focal adhesion assembly (GO:0048041)2.55542218
116glomerular filtration (GO:0003094)2.54642213
117transcytosis (GO:0045056)2.54228673
118dermatan sulfate metabolic process (GO:0030205)2.54131417
119regulation of plasminogen activation (GO:0010755)2.53405476
120phospholipid homeostasis (GO:0055091)2.53347283
121chondroitin sulfate catabolic process (GO:0030207)2.52970505
122acylglycerol catabolic process (GO:0046464)2.52962633
123neutral lipid catabolic process (GO:0046461)2.52962633
124endothelial cell morphogenesis (GO:0001886)2.52911252
125positive regulation of triglyceride metabolic process (GO:0090208)2.52104382
126cysteine metabolic process (GO:0006534)2.51128916
127cellular ketone body metabolic process (GO:0046950)2.50912137
128mannose metabolic process (GO:0006013)2.46788593
129positive regulation of lipoprotein lipase activity (GO:0051006)2.46483436
130positive regulation of triglyceride lipase activity (GO:0061365)2.46483436
131cytoskeletal anchoring at plasma membrane (GO:0007016)2.45379720
132cAMP biosynthetic process (GO:0006171)2.44603224
133regulation of glucose import in response to insulin stimulus (GO:2001273)2.42270079
134collagen fibril organization (GO:0030199)2.41973849
135regulation of apoptotic cell clearance (GO:2000425)2.41958436
136activation of protein kinase A activity (GO:0034199)2.40416737
137negative regulation of smooth muscle cell migration (GO:0014912)2.37905409
138synaptic vesicle docking involved in exocytosis (GO:0016081)2.36052784
139metanephric nephron epithelium development (GO:0072243)2.36022626
140stress fiber assembly (GO:0043149)2.32685258
141adhesion of symbiont to host (GO:0044406)2.28849271
142cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.26407317
143keratan sulfate catabolic process (GO:0042340)2.25798923
144regulation of integrin-mediated signaling pathway (GO:2001044)2.25280576
145virion attachment to host cell (GO:0019062)2.24893728
146adhesion of symbiont to host cell (GO:0044650)2.24893728
147blood vessel maturation (GO:0001955)2.18467201
148regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.18421526
149response to epinephrine (GO:0071871)2.17610154
150endodermal cell differentiation (GO:0035987)2.16051186
151positive regulation of endothelial cell apoptotic process (GO:2000353)2.15476797
152metanephric tubule development (GO:0072170)2.14998919
153metanephric nephron tubule development (GO:0072234)2.14998919
154positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.14733426
155cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.14439455
156negative regulation of catenin import into nucleus (GO:0035414)2.14205366
157myelination in peripheral nervous system (GO:0022011)2.14020600
158peripheral nervous system axon ensheathment (GO:0032292)2.14020600
159type B pancreatic cell proliferation (GO:0044342)2.13518812
160protein targeting to plasma membrane (GO:0072661)2.13514553
161regulation of extracellular matrix disassembly (GO:0010715)2.13012006
162metanephric epithelium development (GO:0072207)2.11614418
163cell proliferation involved in metanephros development (GO:0072203)2.09813188
164ethanol metabolic process (GO:0006067)2.07638938
165glycerolipid catabolic process (GO:0046503)2.06339973
166epithelial cell-cell adhesion (GO:0090136)2.05833761
167regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.05635191

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.62341120
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.59687640
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.24312735
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.74698894
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.60588796
6CLOCK_20551151_ChIP-Seq_293T_Human3.35245493
7RARG_19884340_ChIP-ChIP_MEFs_Mouse3.25576669
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.24022042
9TRIM28_21343339_ChIP-Seq_HEK293_Human3.05314725
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.93172861
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.82863866
12TP63_17297297_ChIP-ChIP_HaCaT_Human2.22129359
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19357258
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15245990
15ESR2_21235772_ChIP-Seq_MCF-7_Human2.11115513
16EP300_21415370_ChIP-Seq_HL-1_Mouse2.04919091
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.04864232
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.98790832
19TBX20_22080862_ChIP-Seq_HEART_Mouse1.98047988
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.98047988
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.93069552
22DROSHA_22980978_ChIP-Seq_HELA_Human1.91348203
23ZNF263_19887448_ChIP-Seq_K562_Human1.83562149
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.78273580
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.74366778
26ESR1_20079471_ChIP-ChIP_T-47D_Human1.74038449
27EGR1_23403033_ChIP-Seq_LIVER_Mouse1.71806400
28TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.69984534
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.67955055
30GATA2_21666600_ChIP-Seq_HMVEC_Human1.61250397
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.55642776
32RNF2_18974828_ChIP-Seq_MESCs_Mouse1.55452691
33EZH2_18974828_ChIP-Seq_MESCs_Mouse1.55452691
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50976251
35LXR_22292898_ChIP-Seq_THP-1_Human1.50910549
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.50797769
37CTCF_27219007_Chip-Seq_Bcells_Human1.49895958
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48921130
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.47285351
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45814160
41EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45595834
42DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44804814
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40789153
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40479998
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.40226145
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.39845427
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39409922
48FOXA2_19822575_ChIP-Seq_HepG2_Human1.37619909
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.35404108
50EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33892232
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.33673668
52RACK7_27058665_Chip-Seq_MCF-7_Human1.33279458
53EZH2_27294783_Chip-Seq_ESCs_Mouse1.33224802
54ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.30953170
55SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.30666543
56SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28612733
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27912035
58SMC4_20622854_ChIP-Seq_HELA_Human1.27469069
59SMC3_22415368_ChIP-Seq_MEFs_Mouse1.27442823
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25590314
61TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24906495
62BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23885265
63ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23631263
64TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.21109569
65SUZ12_27294783_Chip-Seq_ESCs_Mouse1.20517520
66CJUN_26792858_Chip-Seq_BT549_Human1.20243066
67RNF2_27304074_Chip-Seq_ESCs_Mouse1.19013185
68KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18425928
69FOXO3_23340844_ChIP-Seq_DLD1_Human1.17169435
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17089881
71TP53_23651856_ChIP-Seq_MEFs_Mouse1.16665501
72SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16135042
73TET1_21490601_ChIP-Seq_MESCs_Mouse1.15890557
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.15798137
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13541108
76P68_20966046_ChIP-Seq_HELA_Human1.12566919
77SALL4_18804426_ChIP-ChIP_XEN_Mouse1.11908953
78HIF1A_21447827_ChIP-Seq_MCF-7_Human1.11714808
79TCF7_22412390_ChIP-Seq_EML_Mouse1.11431626
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.11340083
81WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.11005844
82GATA1_22025678_ChIP-Seq_K562_Human1.10802343
83CTCF_27219007_Chip-Seq_ERYTHROID_Human1.09132926
84P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08874878
85CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.08328536
86CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08153077
87SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08121465
88SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06729364
89PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05939314
90RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05828841
91KDM2B_26808549_Chip-Seq_K562_Human1.05146005
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.03493227
93SA1_27219007_Chip-Seq_ERYTHROID_Human1.03449929
94TET1_21451524_ChIP-Seq_MESCs_Mouse1.01820316
95GATA1_19941826_ChIP-Seq_K562_Human1.00864557
96NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00016507
97KDM2B_26808549_Chip-Seq_JURKAT_Human0.96910440
98TP53_22127205_ChIP-Seq_IMR90_Human0.95408301
99TP53_20018659_ChIP-ChIP_R1E_Mouse0.94932077
100TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94497376
101CDX2_20551321_ChIP-Seq_CACO-2_Human0.94135089
102FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93373105
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.92420711
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91795618
105SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91390765
106ATF3_27146783_Chip-Seq_COLON_Human0.91149750
107KDM2B_26808549_Chip-Seq_DND41_Human0.90851979
108NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90841435
109WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89160704
110P63_26484246_Chip-Seq_KERATINOCYTES_Human0.88052914
111RUNX1_27514584_Chip-Seq_MCF-7_Human0.87782960
112NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.87751185
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.86942577
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.86942577
115SOX2_20726797_ChIP-Seq_SW620_Human0.86903930
116CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.86735537
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85595891
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.85453759
119PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.85231480
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.85110942
121ERG_21242973_ChIP-ChIP_JURKAT_Human0.84372285
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84013648
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.83904983
124SMC1_22415368_ChIP-Seq_MEFs_Mouse0.83202000
125SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81207727
126SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.80167919
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.79851121
128CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.79787016
129TP63_22573176_ChIP-Seq_HFKS_Human0.79711355
130ZFP281_18757296_ChIP-ChIP_E14_Mouse0.79318001
131PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.79239500
132ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78692215
133CREB1_26743006_Chip-Seq_LNCaP_Human0.78657566
134RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.78525278
135DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.77631473
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77562210
137JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77410886
138HNF4A_19822575_ChIP-Seq_HepG2_Human0.77046548
139GATA2_19941826_ChIP-Seq_K562_Human0.77021620
140STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76539568
141KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.76074666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.80936283
2MP0008438_abnormal_cutaneous_collagen3.45834631
3MP0010368_abnormal_lymphatic_system3.26804922
4MP0004084_abnormal_cardiac_muscle3.05771173
5MP0005670_abnormal_white_adipose2.95794013
6MP0002139_abnormal_hepatobiliary_system2.94606304
7MP0003705_abnormal_hypodermis_morpholog2.82153957
8MP0000751_myopathy2.81211564
9MP0005360_urolithiasis2.79840503
10MP0005365_abnormal_bile_salt2.56924899
11MP0004272_abnormal_basement_membrane2.55534902
12MP0004130_abnormal_muscle_cell2.50826048
13MP0005085_abnormal_gallbladder_physiolo2.40891737
14MP0005275_abnormal_skin_tensile2.33957006
15MP0001879_abnormal_lymphatic_vessel2.24866353
16MP0004036_abnormal_muscle_relaxation2.16605663
17MP0005666_abnormal_adipose_tissue2.15689781
18MP0005330_cardiomyopathy2.12658720
19MP0009780_abnormal_chondrocyte_physiolo1.98770971
20MP0005409_darkened_coat_color1.96618664
21MP0003252_abnormal_bile_duct1.93486168
22MP0004215_abnormal_myocardial_fiber1.92122761
23MP0006138_congestive_heart_failure1.90152838
24MP0003279_aneurysm1.89780978
25MP0003646_muscle_fatigue1.87942947
26MP0008875_abnormal_xenobiotic_pharmacok1.85200628
27MP0010329_abnormal_lipoprotein_level1.84244479
28MP0008775_abnormal_heart_ventricle1.82710851
29MP0004087_abnormal_muscle_fiber1.76649245
30MP0004185_abnormal_adipocyte_glucose1.76339570
31MP0005503_abnormal_tendon_morphology1.69480543
32MP0000749_muscle_degeneration1.68629544
33MP0005375_adipose_tissue_phenotype1.67141037
34MP0005385_cardiovascular_system_phenoty1.66782440
35MP0001544_abnormal_cardiovascular_syste1.66782440
36MP0001958_emphysema1.65675594
37MP0010630_abnormal_cardiac_muscle1.62948804
38MP0000013_abnormal_adipose_tissue1.60048248
39MP0000750_abnormal_muscle_regeneration1.59726443
40MP0003828_pulmonary_edema1.59257939
41MP0005332_abnormal_amino_acid1.56288164
42MP0002933_joint_inflammation1.55397722
43MP0002972_abnormal_cardiac_muscle1.52724084
44MP0003566_abnormal_cell_adhesion1.50258304
45MP0003191_abnormal_cellular_cholesterol1.44880483
46MP0005257_abnormal_intraocular_pressure1.44309792
47MP0005620_abnormal_muscle_contractility1.42106176
48MP0002269_muscular_atrophy1.36821744
49MP0002118_abnormal_lipid_homeostasis1.34258768
50MP0005623_abnormal_meninges_morphology1.32143062
51MP0000003_abnormal_adipose_tissue1.32105553
52MP0004858_abnormal_nervous_system1.31122355
53MP0002249_abnormal_larynx_morphology1.27879685
54MP0005058_abnormal_lysosome_morphology1.23498823
55MP0005167_abnormal_blood-brain_barrier1.22946980
56MP0002971_abnormal_brown_adipose1.21159534
57MP0001849_ear_inflammation1.20236851
58MP0000767_abnormal_smooth_muscle1.17361422
59MP0002295_abnormal_pulmonary_circulatio1.15325487
60MP0002108_abnormal_muscle_morphology1.14558253
61MP0003806_abnormal_nucleotide_metabolis1.14262991
62MP0005319_abnormal_enzyme/_coenzyme1.14110906
63MP0009840_abnormal_foam_cell1.13890457
64MP0009643_abnormal_urine_homeostasis1.11777762
65MP0003879_abnormal_hair_cell1.10466392
66MP0000759_abnormal_skeletal_muscle1.10089428
67MP0003690_abnormal_glial_cell1.09433356
68MP0002106_abnormal_muscle_physiology1.08990064
69MP0004484_altered_response_of1.08716678
70MP0003137_abnormal_impulse_conducting1.07867476
71MP0005083_abnormal_biliary_tract1.07227564
72MP0000343_altered_response_to1.06603762
73MP0000609_abnormal_liver_physiology1.06226883
74MP0003195_calcinosis1.05312079
75MP0000747_muscle_weakness1.04137046
76MP0002128_abnormal_blood_circulation1.03730909
77MP0005171_absent_coat_pigmentation1.02339874
78MP0005369_muscle_phenotype1.01662979
79MP0002138_abnormal_hepatobiliary_system0.99804488
80MP0004233_abnormal_muscle_weight0.99358574
81MP0005165_increased_susceptibility_to0.98875851
82MP0009384_cardiac_valve_regurgitation0.97232259
83MP0000230_abnormal_systemic_arterial0.96795958
84MP0004510_myositis0.96528467
85MP0001661_extended_life_span0.95727620
86MP0002060_abnormal_skin_morphology0.93391882
87MP0001299_abnormal_eye_distance/0.92142211
88MP0004085_abnormal_heartbeat0.92068006
89MP0001756_abnormal_urination0.89109859
90MP0009115_abnormal_fat_cell0.88285665
91MP0005595_abnormal_vascular_smooth0.87650720
92MP0006054_spinal_hemorrhage0.86353195
93MP0001542_abnormal_bone_strength0.85999462
94MP0005023_abnormal_wound_healing0.85998034
95MP0001666_abnormal_nutrient_absorption0.85608817
96MP0000266_abnormal_heart_morphology0.84717115
97MP0001502_abnormal_circadian_rhythm0.84493304
98MP0001348_abnormal_lacrimal_gland0.83185512
99MP0005334_abnormal_fat_pad0.82194322
100MP0003950_abnormal_plasma_membrane0.82067016
101MP0003045_fibrosis0.80393324
102MP0002168_other_aberrant_phenotype0.79897913
103MP0010030_abnormal_orbit_morphology0.79415442
104MP0003329_amyloid_beta_deposits0.77816285
105MP0002970_abnormal_white_adipose0.77740711
106MP0002127_abnormal_cardiovascular_syste0.77556314
107MP0005164_abnormal_response_to0.76810565
108MP0008961_abnormal_basal_metabolism0.76281833
109MP0001614_abnormal_blood_vessel0.75876403
110MP0002133_abnormal_respiratory_system0.75692122
111MP0005388_respiratory_system_phenotype0.75692122
112MP0002332_abnormal_exercise_endurance0.75396586
113MP0003091_abnormal_cell_migration0.75320172
114MP0000249_abnormal_blood_vessel0.73763083
115MP0005535_abnormal_body_temperature0.72977991
116MP0003221_abnormal_cardiomyocyte_apopto0.72687117
117MP0000163_abnormal_cartilage_morphology0.72538616
118MP0003724_increased_susceptibility_to0.72407903
119MP0002998_abnormal_bone_remodeling0.72187836
120MP0003283_abnormal_digestive_organ0.71449306
121MP0000733_abnormal_muscle_development0.71367148
122MP0005076_abnormal_cell_differentiation0.71292679
123MP0003868_abnormal_feces_composition0.71215693
124MP0005508_abnormal_skeleton_morphology0.70419838
125MP0002896_abnormal_bone_mineralization0.70206380
126MP0006036_abnormal_mitochondrial_physio0.70004349
127MP0000678_abnormal_parathyroid_gland0.69634972
128MP0004019_abnormal_vitamin_homeostasis0.69462827
129MP0004145_abnormal_muscle_electrophysio0.69300913
130MP0004782_abnormal_surfactant_physiolog0.67160378

Predicted human phenotypes

RankGene SetZ-score
1Increased connective tissue (HP:0009025)4.12202500
2Muscle fiber splitting (HP:0003555)3.94084817
3Deep venous thrombosis (HP:0002625)3.89615298
4Broad metatarsal (HP:0001783)3.87235858
5Sudden death (HP:0001699)3.75486615
6Right ventricular cardiomyopathy (HP:0011663)3.72415794
7Protrusio acetabuli (HP:0003179)3.55901786
8Ventricular tachycardia (HP:0004756)3.52917949
9Obstructive sleep apnea (HP:0002870)3.46229072
10Hyporeflexia of lower limbs (HP:0002600)3.40558169
11Cervical subluxation (HP:0003308)3.37148038
12Polycythemia (HP:0001901)3.35466744
13Hypoglycemic coma (HP:0001325)3.31533079
14Myoglobinuria (HP:0002913)3.29649338
15Ketoacidosis (HP:0001993)3.26644550
16Mesangial abnormality (HP:0001966)3.18859634
17Ketosis (HP:0001946)3.16589419
18Ankle contracture (HP:0006466)3.02801639
19Lipoatrophy (HP:0100578)3.02607956
20Cerebral aneurysm (HP:0004944)3.02359384
21Vascular tortuosity (HP:0004948)3.01125095
22Abnormality of fatty-acid metabolism (HP:0004359)2.97902562
23Hyperglycinuria (HP:0003108)2.97448192
24Premature rupture of membranes (HP:0001788)2.95511592
25Xanthomatosis (HP:0000991)2.95088602
26Round ear (HP:0100830)2.86994027
27Exercise-induced myalgia (HP:0003738)2.86981527
28Lymphangioma (HP:0100764)2.86324076
29Type 1 muscle fiber predominance (HP:0003803)2.86295643
30Wormian bones (HP:0002645)2.80319492
31Hyperammonemia (HP:0001987)2.78371020
32Atrial fibrillation (HP:0005110)2.78237327
33Increased variability in muscle fiber diameter (HP:0003557)2.75742067
34Joint stiffness (HP:0001387)2.73587043
35Bladder diverticulum (HP:0000015)2.71939169
36Difficulty running (HP:0009046)2.70303606
37Asymmetric septal hypertrophy (HP:0001670)2.70217645
38Complement deficiency (HP:0004431)2.68634747
39Hypoalphalipoproteinemia (HP:0003233)2.67028785
40Distal lower limb muscle weakness (HP:0009053)2.64510708
41Wrist flexion contracture (HP:0001239)2.62498122
42Systemic lupus erythematosus (HP:0002725)2.59411003
43Abnormality of glycine metabolism (HP:0010895)2.58333296
44Abnormality of serine family amino acid metabolism (HP:0010894)2.58333296
45Arterial tortuosity (HP:0005116)2.56836548
46Thin bony cortex (HP:0002753)2.55738849
47Primary atrial arrhythmia (HP:0001692)2.52803101
48Aortic regurgitation (HP:0001659)2.51665266
49Distal lower limb amyotrophy (HP:0008944)2.50907117
50Vertebral compression fractures (HP:0002953)2.50579720
51Aneurysm (HP:0002617)2.49512494
52Exercise-induced muscle cramps (HP:0003710)2.49113851
53Intrahepatic cholestasis (HP:0001406)2.47894496
54Hyperlipoproteinemia (HP:0010980)2.46876002
55Spinal rigidity (HP:0003306)2.46025450
56Atrioventricular block (HP:0001678)2.45739699
57Soft skin (HP:0000977)2.45187331
58Biconcave vertebral bodies (HP:0004586)2.45063773
59Supraventricular arrhythmia (HP:0005115)2.43046299
60Aortic aneurysm (HP:0004942)2.41260674
61Calf muscle hypertrophy (HP:0008981)2.41041435
62Dilated cardiomyopathy (HP:0001644)2.40710722
63Mitral regurgitation (HP:0001653)2.39089850
64Abnormality of skeletal muscle fiber size (HP:0012084)2.39056446
65Abnormality of the calf musculature (HP:0001430)2.38610906
66Supraventricular tachycardia (HP:0004755)2.36850884
67Abnormality of aromatic amino acid family metabolism (HP:0004338)2.35361278
68Atrophic scars (HP:0001075)2.32971284
69Fragile skin (HP:0001030)2.32245533
70Dilatation of the ascending aorta (HP:0005111)2.30404223
71Rhabdomyolysis (HP:0003201)2.30312764
72J-shaped sella turcica (HP:0002680)2.29450995
73Dicarboxylic aciduria (HP:0003215)2.27918538
74Abnormality of dicarboxylic acid metabolism (HP:0010995)2.27918538
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.27202408
76Skin nodule (HP:0200036)2.25833634
77Broad face (HP:0000283)2.25548128
78Focal segmental glomerulosclerosis (HP:0000097)2.23893258
79Aortic valve stenosis (HP:0001650)2.23506783
80Esophageal varix (HP:0002040)2.22933577
81Myocardial infarction (HP:0001658)2.22706245
82Nuclear cataract (HP:0100018)2.21970566
83Blue sclerae (HP:0000592)2.19675438
84Difficulty climbing stairs (HP:0003551)2.19528380
85Shallow orbits (HP:0000586)2.19356880
86Palpitations (HP:0001962)2.19341119
87Mildly elevated creatine phosphokinase (HP:0008180)2.18930854
88Aortic dissection (HP:0002647)2.18400729
89Overgrowth (HP:0001548)2.18056632
90Hypoplastic ischia (HP:0003175)2.15985694
91Mitral stenosis (HP:0001718)2.15958145
92Stridor (HP:0010307)2.14099245
93Abnormality of monocarboxylic acid metabolism (HP:0010996)2.12066729
94Acanthosis nigricans (HP:0000956)2.10714149
95Ectopia lentis (HP:0001083)2.08823153
96Abnormal atrioventricular conduction (HP:0005150)2.07932807
97Heart block (HP:0012722)2.07072606
98Muscle hypertrophy of the lower extremities (HP:0008968)2.06463133
99EMG: myopathic abnormalities (HP:0003458)2.05980667
100Syncope (HP:0001279)2.05642352
101Abnormality of glutamine family amino acid metabolism (HP:0010902)2.04792001
102Visceral angiomatosis (HP:0100761)2.03828747
103Hyperglycinemia (HP:0002154)2.03426374
104Hypoplasia of the iris (HP:0007676)2.02899874
105Abnormality of the ischium (HP:0003174)2.02081366
106Nephritis (HP:0000123)2.01865311
107Bundle branch block (HP:0011710)2.01249015
108Joint hemorrhage (HP:0005261)2.00675271
109Hypolipoproteinemia (HP:0010981)1.99898054
110Pulmonary artery stenosis (HP:0004415)1.99806245
111Subaortic stenosis (HP:0001682)1.99783512
112Abnormality of the left ventricular outflow tract (HP:0011103)1.99783512
113Turricephaly (HP:0000262)1.99577286
114Bronchomalacia (HP:0002780)1.96613295
115Slender build (HP:0001533)1.96141433
116Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.95219360
117Gout (HP:0001997)1.95209741
118Distal upper limb amyotrophy (HP:0007149)1.94697304
119Upper limb amyotrophy (HP:0009129)1.94697304
120Joint laxity (HP:0001388)1.94126343
121Hematochezia (HP:0002573)1.93825843
122Myotonia (HP:0002486)1.93079883
123Neck muscle weakness (HP:0000467)1.92886696
124Lower limb amyotrophy (HP:0007210)1.92138455
125Glomerulonephritis (HP:0000099)1.92045125
126Epidermoid cyst (HP:0200040)1.90969062
127Glomerulosclerosis (HP:0000096)1.90647970
128Abnormality of complement system (HP:0005339)1.90578257
129Abnormal cartilage morphology (HP:0002763)1.90395772
130Mucopolysacchariduria (HP:0008155)1.89415652
131Urinary glycosaminoglycan excretion (HP:0003541)1.89415652
132Generalized aminoaciduria (HP:0002909)1.89232180
133Ventricular arrhythmia (HP:0004308)1.89121560
134Hydroxyprolinuria (HP:0003080)1.88099371
135Abnormality of proline metabolism (HP:0010907)1.88099371
136Hyperglycemia (HP:0003074)1.87425728
137Hemangiomatosis (HP:0007461)1.87244820
138Oligomenorrhea (HP:0000876)1.87163719
139Neonatal short-limb short stature (HP:0008921)1.86188736
140Follicular hyperkeratosis (HP:0007502)1.86062625
141Generalized amyotrophy (HP:0003700)1.85384051
142Venous abnormality (HP:0002624)1.85236521
143Hypertriglyceridemia (HP:0002155)1.84698854
144Mitral valve prolapse (HP:0001634)1.83340265
145Hip contracture (HP:0003273)1.83190528
146Infantile muscular hypotonia (HP:0008947)1.82177933
147Abnormality of polysaccharide metabolism (HP:0011012)1.80612956
148Abnormality of glycosaminoglycan metabolism (HP:0004371)1.80612956
149Abnormality of mucopolysaccharide metabolism (HP:0011020)1.80612956
150Striae distensae (HP:0001065)1.80270149
151Long toe (HP:0010511)1.79573303
152Prolonged QT interval (HP:0001657)1.79392252
153Ulnar bowing (HP:0003031)1.78875039
154Centrally nucleated skeletal muscle fibers (HP:0003687)1.78725300
155Axonal loss (HP:0003447)1.78404272
156Hemorrhage of the eye (HP:0011885)1.78231397
157Limited hip movement (HP:0008800)1.76735385
158Bradycardia (HP:0001662)1.75956697
159Hyperextensible skin (HP:0000974)1.75533016

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.14468299
2TRIB34.11206771
3TTN3.58379240
4BCKDK3.07273997
5ERN13.05491864
6SIK12.66791438
7PDGFRA2.41904263
8TGFBR22.41575442
9PKN22.37798195
10KDR2.35821654
11MYLK2.35740570
12WNK42.21215477
13DDR22.11108952
14RIPK12.10972289
15EPHB21.89622049
16LATS11.83076471
17FGFR41.78094990
18LMTK21.72282572
19CAMK1D1.68754314
20EEF2K1.65116771
21PHKG11.60232572
22PHKG21.60232572
23PDK41.56418928
24PDK31.56418928
25TESK11.54737020
26DMPK1.54725538
27NTRK11.51167170
28MARK21.42142111
29ICK1.39142339
30INSRR1.36919710
31EPHB11.36621567
32PINK11.33225951
33PTK61.27066307
34MAP2K31.24399618
35PDK21.23480459
36CAMK1G1.22953318
37RPS6KA21.14625797
38LATS21.13346510
39NTRK31.11322681
40MAPK151.10042622
41MAPK71.09354682
42OBSCN1.08866882
43EPHA21.08795861
44TGFBR11.08563301
45PRKD11.04367228
46PIK3CA1.02221583
47AKT31.01818250
48EPHA31.00476256
49FER0.99500532
50PRKAA20.98403845
51PRPF4B0.94089773
52MET0.93088610
53CAMK10.93066506
54MAP3K30.92896573
55MUSK0.91432758
56MAP3K70.90511183
57STK38L0.88079627
58BMX0.87816921
59FGFR20.86404213
60MAP3K60.85054679
61PRKD20.84537681
62STK390.82565655
63MARK10.81148909
64PDGFRB0.80386539
65PAK30.79569559
66PTK20.79244001
67FLT30.78931606
68MAP2K60.78837289
69PTK2B0.78377751
70MTOR0.78142118
71MAPK40.73677812
72TRPM70.72390352
73MAP3K130.71956122
74MST1R0.71873836
75LRRK20.70847815
76PRKAA10.69729867
77ROCK10.68895785
78PAK20.68705600
79ILK0.68553074
80PRKD30.68537874
81PAK40.67059479
82NEK90.66809995
83PRKCH0.66227829
84JAK10.64577277
85MAPK120.64161207
86GSK3A0.63489517
87CSK0.62523257
88CDC42BPA0.62019671
89FGFR30.61468811
90PAK60.60022668
91HIPK20.59503830
92GRK50.59353098
93RET0.56700577
94CAMK2G0.56566305
95TNK20.56515486
96MAP3K110.55277006
97MAPK110.54997892
98LIMK10.54914748
99MAP2K10.52377128
100KIT0.52250489
101ERBB20.52013939
102MAPKAPK30.51786416
103DAPK20.51076766
104ROCK20.51075440
105SGK2230.49585305
106SGK4940.49585305
107DAPK30.49354779
108PDPK10.48731492
109ZAP700.48092418
110PRKG20.47862270
111CAMK2B0.47576097
112FRK0.46215195
113CAMK40.45435177
114FGFR10.44331999
115MAP3K10.42651140
116JAK20.42356765
117CAMK2D0.41915887
118STK380.41616001
119DYRK1B0.41049072
120NEK10.40560903
121CDK60.38866913
122OXSR10.38850362
123WNK10.36663354
124RPS6KC10.36386708
125RPS6KL10.36386708
126MAP3K100.35338677
127RPS6KA60.34431350
128STK30.33875239
129TYRO30.33639467
130ABL20.33266943
131SGK30.32871821
132PIK3CG0.32507976
133PRKACG0.31831216

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid degradation_Homo sapiens_hsa000713.18805449
2Propanoate metabolism_Homo sapiens_hsa006403.07928783
32-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.98430037
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.96825898
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.94653909
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.80273124
7Fatty acid metabolism_Homo sapiens_hsa012122.72530447
8PPAR signaling pathway_Homo sapiens_hsa033202.50119709
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.36206452
10Nitrogen metabolism_Homo sapiens_hsa009102.32284533
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.24487300
12Tryptophan metabolism_Homo sapiens_hsa003802.21065650
13Arginine biosynthesis_Homo sapiens_hsa002202.19120412
14Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.93399262
15Butanoate metabolism_Homo sapiens_hsa006501.86227005
16Complement and coagulation cascades_Homo sapiens_hsa046101.78896438
17Fatty acid biosynthesis_Homo sapiens_hsa000611.72037595
18Pyruvate metabolism_Homo sapiens_hsa006201.69948580
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68636425
20Carbon metabolism_Homo sapiens_hsa012001.61500277
21ECM-receptor interaction_Homo sapiens_hsa045121.57231587
22beta-Alanine metabolism_Homo sapiens_hsa004101.53342826
23Other glycan degradation_Homo sapiens_hsa005111.52573990
24Peroxisome_Homo sapiens_hsa041461.51907934
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51210211
26Dilated cardiomyopathy_Homo sapiens_hsa054141.45787253
27Caffeine metabolism_Homo sapiens_hsa002321.43183472
28Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39237804
29Pentose and glucuronate interconversions_Homo sapiens_hsa000401.35369950
30Lysine degradation_Homo sapiens_hsa003101.28987765
31Starch and sucrose metabolism_Homo sapiens_hsa005001.27323750
32Bile secretion_Homo sapiens_hsa049761.24507302
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.22390800
34Fatty acid elongation_Homo sapiens_hsa000621.19051893
35Focal adhesion_Homo sapiens_hsa045101.17035462
36Renin secretion_Homo sapiens_hsa049241.15219223
37Phenylalanine metabolism_Homo sapiens_hsa003601.14715807
38Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.14541833
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.13160919
40Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.12491481
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12391084
42Phospholipase D signaling pathway_Homo sapiens_hsa040721.11962537
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.11884939
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.10953065
45Insulin resistance_Homo sapiens_hsa049311.09887038
46Fat digestion and absorption_Homo sapiens_hsa049751.05028658
47Biosynthesis of amino acids_Homo sapiens_hsa012301.02395201
48Chemical carcinogenesis_Homo sapiens_hsa052041.02173019
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.00136377
50Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97229635
51Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.96215031
52GnRH signaling pathway_Homo sapiens_hsa049120.96182548
53Glycerolipid metabolism_Homo sapiens_hsa005610.94204000
54Protein digestion and absorption_Homo sapiens_hsa049740.90482825
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89886506
56ABC transporters_Homo sapiens_hsa020100.89465686
57Tyrosine metabolism_Homo sapiens_hsa003500.88870742
58Arginine and proline metabolism_Homo sapiens_hsa003300.88011700
59Insulin secretion_Homo sapiens_hsa049110.87872813
60Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.87717419
61Gastric acid secretion_Homo sapiens_hsa049710.85652847
62AMPK signaling pathway_Homo sapiens_hsa041520.84482846
63Estrogen signaling pathway_Homo sapiens_hsa049150.83641267
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82798131
65Staphylococcus aureus infection_Homo sapiens_hsa051500.81515630
66Sulfur metabolism_Homo sapiens_hsa009200.79855538
67Melanogenesis_Homo sapiens_hsa049160.76769033
68Histidine metabolism_Homo sapiens_hsa003400.76462857
69Oxytocin signaling pathway_Homo sapiens_hsa049210.75357070
70Amoebiasis_Homo sapiens_hsa051460.74644745
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73678918
72Axon guidance_Homo sapiens_hsa043600.73591581
73Selenocompound metabolism_Homo sapiens_hsa004500.73408825
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73026675
75Adherens junction_Homo sapiens_hsa045200.72400078
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.72294627
77cAMP signaling pathway_Homo sapiens_hsa040240.72060040
78Fructose and mannose metabolism_Homo sapiens_hsa000510.71544074
79VEGF signaling pathway_Homo sapiens_hsa043700.70589687
80Gap junction_Homo sapiens_hsa045400.70456532
81Thyroid hormone synthesis_Homo sapiens_hsa049180.69530729
82Retinol metabolism_Homo sapiens_hsa008300.69318829
83Long-term potentiation_Homo sapiens_hsa047200.67928693
84Glucagon signaling pathway_Homo sapiens_hsa049220.67630391
85Cocaine addiction_Homo sapiens_hsa050300.66681914
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65617542
87Insulin signaling pathway_Homo sapiens_hsa049100.65025889
88Circadian entrainment_Homo sapiens_hsa047130.63805467
89Calcium signaling pathway_Homo sapiens_hsa040200.62516295
90Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59962129
91Rap1 signaling pathway_Homo sapiens_hsa040150.59230864
92Salivary secretion_Homo sapiens_hsa049700.58007596
93Cardiac muscle contraction_Homo sapiens_hsa042600.57989896
94AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57584614
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.57496382
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57224380
97Proteoglycans in cancer_Homo sapiens_hsa052050.56298227
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56238608
99Glioma_Homo sapiens_hsa052140.55622509
100Pertussis_Homo sapiens_hsa051330.54759595
101Viral myocarditis_Homo sapiens_hsa054160.54600714
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.53127209
103Vitamin B6 metabolism_Homo sapiens_hsa007500.52435743
104Choline metabolism in cancer_Homo sapiens_hsa052310.51480829
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.50454767
106Small cell lung cancer_Homo sapiens_hsa052220.49801283
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49641929
108Pancreatic secretion_Homo sapiens_hsa049720.49158843
109Amphetamine addiction_Homo sapiens_hsa050310.48464676
110Platelet activation_Homo sapiens_hsa046110.46861147
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46769047
112Glutamatergic synapse_Homo sapiens_hsa047240.46341129
113Cysteine and methionine metabolism_Homo sapiens_hsa002700.44600163
114Drug metabolism - other enzymes_Homo sapiens_hsa009830.43413086
115PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40017355
116Bladder cancer_Homo sapiens_hsa052190.39354056
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.38429073
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.36828220
119Galactose metabolism_Homo sapiens_hsa000520.34863257
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.34725574
121Tight junction_Homo sapiens_hsa045300.34197656
122Vitamin digestion and absorption_Homo sapiens_hsa049770.34000818
123Sulfur relay system_Homo sapiens_hsa041220.32499412
124Ovarian steroidogenesis_Homo sapiens_hsa049130.32485065
125Folate biosynthesis_Homo sapiens_hsa007900.31624574
126Glutathione metabolism_Homo sapiens_hsa004800.30845799
127Notch signaling pathway_Homo sapiens_hsa043300.30308563
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.28088274
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.27204281
130Prion diseases_Homo sapiens_hsa050200.26254932
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.25151406
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.24932029
133Cyanoamino acid metabolism_Homo sapiens_hsa004600.23015749
134Circadian rhythm_Homo sapiens_hsa047100.21901629
135mTOR signaling pathway_Homo sapiens_hsa041500.21853383
136Dorso-ventral axis formation_Homo sapiens_hsa043200.21218822
137Renin-angiotensin system_Homo sapiens_hsa046140.20564219
138Glycosaminoglycan degradation_Homo sapiens_hsa005310.20126070

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