TNRC18P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of cellular amide metabolic process (GO:0034250)4.54829681
2regulation of cell proliferation involved in kidney development (GO:1901722)4.38215757
3histone H3-K36 demethylation (GO:0070544)4.20610344
4keratinization (GO:0031424)4.10159759
5regulation of histone H3-K27 methylation (GO:0061085)3.43831162
6cellular response to ethanol (GO:0071361)3.32334287
7regulation of Cdc42 GTPase activity (GO:0043088)3.17156971
8regulation of establishment of cell polarity (GO:2000114)3.16880805
9positive regulation of keratinocyte differentiation (GO:0045618)3.13786389
10interferon-gamma secretion (GO:0072643)3.11914773
11ear development (GO:0043583)3.10846882
12positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.02767684
13histone H3-K4 trimethylation (GO:0080182)3.02638926
14insulin-like growth factor receptor signaling pathway (GO:0048009)2.99634579
15regulation of establishment or maintenance of cell polarity (GO:0032878)2.98271210
16regulation of MHC class I biosynthetic process (GO:0045343)2.96285892
17positive regulation of humoral immune response (GO:0002922)2.92488415
18establishment of skin barrier (GO:0061436)2.88709474
19histone lysine demethylation (GO:0070076)2.87059673
20activation of Rac GTPase activity (GO:0032863)2.83922794
21regulation of water loss via skin (GO:0033561)2.79858739
22regulation of T-helper 2 cell differentiation (GO:0045628)2.79671350
23negative regulation of osteoblast proliferation (GO:0033689)2.79391817
24striated muscle atrophy (GO:0014891)2.77655353
25semaphorin-plexin signaling pathway (GO:0071526)2.77444149
26histone demethylation (GO:0016577)2.75687016
27protein K11-linked deubiquitination (GO:0035871)2.68416096
28positive regulation of histone deacetylation (GO:0031065)2.67973368
29mannose metabolic process (GO:0006013)2.66717271
30macrophage activation involved in immune response (GO:0002281)2.61904222
31negative regulation of interleukin-8 production (GO:0032717)2.61628138
32macroautophagy (GO:0016236)2.60890915
33histone H3-K4 methylation (GO:0051568)2.58492837
34positive regulation of Rac GTPase activity (GO:0032855)2.57859543
35endothelial cell chemotaxis (GO:0035767)2.55822859
36negative regulation of granulocyte differentiation (GO:0030853)2.54331593
37positive regulation of Cdc42 GTPase activity (GO:0043089)2.51608981
38positive regulation of cholesterol efflux (GO:0010875)2.50963532
39positive regulation of protein kinase C signaling (GO:0090037)2.50382326
40skeletal muscle adaptation (GO:0043501)2.48766906
41histone H3-K9 demethylation (GO:0033169)2.48492652
42regulation of ruffle assembly (GO:1900027)2.47823349
43filopodium assembly (GO:0046847)2.47558002
44adherens junction assembly (GO:0034333)2.43746736
45snRNA transcription (GO:0009301)2.43525332
46cell-cell junction maintenance (GO:0045217)2.43503922
47intracellular estrogen receptor signaling pathway (GO:0030520)2.43197004
48positive regulation of epidermis development (GO:0045684)2.43029126
49regulation of interleukin-12 biosynthetic process (GO:0045075)2.38944516
50detection of molecule of bacterial origin (GO:0032490)2.38789442
51phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.36193169
52positive regulation of glomerulus development (GO:0090193)2.36070055
53protein K48-linked deubiquitination (GO:0071108)2.35887435
54positive regulation of Rho GTPase activity (GO:0032321)2.35784775
55ovulation (GO:0030728)2.34347667
56regulation of ARF GTPase activity (GO:0032312)2.34292008
57positive regulation of p38MAPK cascade (GO:1900745)2.33876719
58dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.33527143
59negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)2.32272015
60protein demethylation (GO:0006482)2.30803433
61protein dealkylation (GO:0008214)2.30803433
62response to peptidoglycan (GO:0032494)2.29464388
63regulation of cellular amide metabolic process (GO:0034248)2.28683231
64negative regulation of cell size (GO:0045792)2.27811414
65regulation of fatty acid beta-oxidation (GO:0031998)2.27712819
66negative regulation of fatty acid transport (GO:2000192)2.26397408
67embryonic camera-type eye morphogenesis (GO:0048596)2.25944757
68receptor catabolic process (GO:0032801)2.25362249
69white fat cell differentiation (GO:0050872)2.25283106
70positive regulation of type 2 immune response (GO:0002830)2.25241356
71regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.25055017
72regulation of ARF protein signal transduction (GO:0032012)2.24467564
73focal adhesion assembly (GO:0048041)2.23874910
74cell-substrate adherens junction assembly (GO:0007045)2.23874910
75negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.23732157
76regulation of p38MAPK cascade (GO:1900744)2.23552371
77corticosteroid receptor signaling pathway (GO:0031958)2.22877057
78positive regulation of epidermal cell differentiation (GO:0045606)2.22327961
79positive regulation of protein deacetylation (GO:0090312)2.22243386
80positive regulation of receptor recycling (GO:0001921)2.20398153
81regulation of histone deacetylation (GO:0031063)2.19424851
82response to muramyl dipeptide (GO:0032495)2.17484173
83peptidyl-lysine trimethylation (GO:0018023)2.17443633
84TOR signaling (GO:0031929)2.17191352
85establishment of protein localization to Golgi (GO:0072600)2.15642814
86histone lysine methylation (GO:0034968)2.15332095
87negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.15123175
88regulation of platelet-derived growth factor receptor signaling pathway (GO:0010640)2.13582977
89fibroblast migration (GO:0010761)2.13238656
90positive regulation of macroautophagy (GO:0016239)2.13137605
91positive regulation of osteoblast proliferation (GO:0033690)2.12691853
92germinal center formation (GO:0002467)2.12120612
93regulation of transforming growth factor beta1 production (GO:0032908)2.11032156
94CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.10896143
95T-helper cell differentiation (GO:0042093)2.10896143
96phosphatidylinositol 3-kinase signaling (GO:0014065)2.10494662
97regulation of phosphatidylinositol 3-kinase activity (GO:0043551)2.10084726
98regulation of dendritic cell antigen processing and presentation (GO:0002604)2.09774744
99angiogenesis involved in wound healing (GO:0060055)2.09602587
100macrophage activation (GO:0042116)2.08758061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human4.29074778
2ESR2_21235772_ChIP-Seq_MCF-7_Human3.71611478
3ESR1_21235772_ChIP-Seq_MCF-7_Human3.00116414
4TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.83568201
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.66033551
6BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.53587449
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.51887482
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.45055463
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.41987434
10ZNF217_24962896_ChIP-Seq_MCF-7_Human2.39076118
11AHR_22903824_ChIP-Seq_MCF-7_Human2.37744214
12RUNX1_27514584_Chip-Seq_MCF-7_Human2.31378724
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.26856421
14DROSHA_22980978_ChIP-Seq_HELA_Human2.24569222
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.19042371
16HIF1A_21447827_ChIP-Seq_MCF-7_Human2.16170227
17TCF7_22412390_ChIP-Seq_EML_Mouse2.06137457
18KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.95767426
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86832997
20RACK7_27058665_Chip-Seq_MCF-7_Human1.81481588
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80907248
22ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.80432897
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.75137632
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.74217835
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.73751420
26KDM2B_26808549_Chip-Seq_DND41_Human1.73748733
27VDR_21846776_ChIP-Seq_THP-1_Human1.72348322
28STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70191751
29Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.69866338
30ARNT_22903824_ChIP-Seq_MCF-7_Human1.66752893
31MYC_22102868_ChIP-Seq_BL_Human1.64441521
32KDM2B_26808549_Chip-Seq_K562_Human1.63738852
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.63305773
34E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.62684271
35GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.58908998
36ELK3_25401928_ChIP-Seq_HUVEC_Human1.56044903
37SOX9_24532713_ChIP-Seq_HFSC_Mouse1.56023271
38IRF8_27001747_Chip-Seq_BMDM_Mouse1.52732467
39SPI1_23127762_ChIP-Seq_K562_Human1.52551643
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.51052879
41PKCTHETA_26484144_Chip-Seq_BREAST_Human1.48180030
42VDR_24763502_ChIP-Seq_THP-1_Human1.46584257
43LXR_22292898_ChIP-Seq_THP-1_Human1.45426122
44ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.42175726
45NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41793848
46SCL_19346495_ChIP-Seq_HPC-7_Human1.36407642
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.36235222
48STAT6_21828071_ChIP-Seq_BEAS2B_Human1.35106347
49NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.32279819
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.30712483
51RARG_19884340_ChIP-ChIP_MEFs_Mouse1.29815982
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.29775858
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26151156
54KDM2B_26808549_Chip-Seq_JURKAT_Human1.26035953
55SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.24654994
56MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24083137
57FOXA2_19822575_ChIP-Seq_HepG2_Human1.23391235
58SMC4_20622854_ChIP-Seq_HELA_Human1.21913986
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21084433
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21084433
61P63_26484246_Chip-Seq_KERATINOCYTES_Human1.19772545
62FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.19771106
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18026755
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.17914441
65ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16266425
66TP53_22127205_ChIP-Seq_IMR90_Human1.12778374
67FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.11708943
68TP53_16413492_ChIP-PET_HCT116_Human1.11057013
69MAF_26560356_Chip-Seq_TH1_Human1.09049659
70CREB1_26743006_Chip-Seq_LNCaP_Human1.08648038
71VDR_24787735_ChIP-Seq_THP-1_Human1.08340507
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.07182163
73EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07005645
74BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06441991
75EGR1_19374776_ChIP-ChIP_THP-1_Human1.04899083
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04393847
77UBF1/2_26484160_Chip-Seq_HMECs_Human1.04287748
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02775982
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02227870
80RUNX_20019798_ChIP-Seq_JUKART_Human1.01786010
81KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00915394
82ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98778463
83CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.98739758
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98429139
85DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97696009
86KLF5_25053715_ChIP-Seq_YYC3_Human0.96955112
87TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96717828
88IRF8_21731497_ChIP-ChIP_J774_Mouse0.96473892
89ESR1_15608294_ChIP-ChIP_MCF-7_Human0.95413940
90NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95065298
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91321068
92PPAR_26484153_Chip-Seq_NCI-H1993_Human0.90779102
93CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89988911
94TP63_22573176_ChIP-Seq_HFKS_Human0.89160006
95TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88405558
96WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87875161
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.87239041
98ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86919377
99GATA3_24758297_ChIP-Seq_MCF-7_Human0.86386366
100RUNX1_22412390_ChIP-Seq_EML_Mouse0.85245448

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle3.81140094
2MP0005076_abnormal_cell_differentiation3.55901124
3MP0002796_impaired_skin_barrier3.02044100
4MP0003705_abnormal_hypodermis_morpholog2.90872989
5MP0000383_abnormal_hair_follicle2.76484755
6MP0005409_darkened_coat_color2.66027464
7MP0003183_abnormal_peptide_metabolism2.50944913
8MP0005058_abnormal_lysosome_morphology2.48439649
9MP0003172_abnormal_lysosome_physiology2.42312487
10MP0005451_abnormal_body_composition2.40765721
11MP0010678_abnormal_skin_adnexa2.36375313
12MP0003303_peritoneal_inflammation2.32327543
13MP0002009_preneoplasia2.29543735
14MP0005167_abnormal_blood-brain_barrier2.12974813
15MP0005310_abnormal_salivary_gland2.08120235
16MP0003453_abnormal_keratinocyte_physiol2.01564122
17MP0009278_abnormal_bone_marrow2.00116239
18MP0010234_abnormal_vibrissa_follicle1.96972720
19MP0000371_diluted_coat_color1.93365643
20MP0000569_abnormal_digit_pigmentation1.91108091
21MP0004510_myositis1.90393460
22MP0003191_abnormal_cellular_cholesterol1.89802432
23MP0003091_abnormal_cell_migration1.79951449
24MP0000767_abnormal_smooth_muscle1.74195343
25MP0008961_abnormal_basal_metabolism1.72967370
26MP0004947_skin_inflammation1.69423685
27MP0001873_stomach_inflammation1.65849119
28MP0002254_reproductive_system_inflammat1.63961611
29MP0008260_abnormal_autophagy1.61102509
30MP0002998_abnormal_bone_remodeling1.55175807
31MP0005670_abnormal_white_adipose1.53837557
32MP0001849_ear_inflammation1.47588237
33MP0005501_abnormal_skin_physiology1.42042559
34MP0009115_abnormal_fat_cell1.40648638
35MP0002098_abnormal_vibrissa_morphology1.38729942
36MP0003436_decreased_susceptibility_to1.36011416
37MP0002332_abnormal_exercise_endurance1.34011750
38MP0005377_hearing/vestibular/ear_phenot1.29081860
39MP0003878_abnormal_ear_physiology1.29081860
40MP0001790_abnormal_immune_system1.28116634
41MP0005387_immune_system_phenotype1.28116634
42MP0001800_abnormal_humoral_immune1.24640287
43MP0005375_adipose_tissue_phenotype1.22544986
44MP0003656_abnormal_erythrocyte_physiolo1.21330200
45MP0002419_abnormal_innate_immunity1.20831677
46MP0001835_abnormal_antigen_presentation1.20727317
47MP0002970_abnormal_white_adipose1.17923044
48MP0004264_abnormal_extraembryonic_tissu1.17048157
49MP0001545_abnormal_hematopoietic_system1.16857317
50MP0005397_hematopoietic_system_phenotyp1.16857317
51MP0002452_abnormal_antigen_presenting1.14975860
52MP0004233_abnormal_muscle_weight1.12287836
53MP0005647_abnormal_sex_gland1.11272347
54MP0006082_CNS_inflammation1.10189032
55MP0003279_aneurysm1.07771903
56MP0000003_abnormal_adipose_tissue1.07192054
57MP0000249_abnormal_blood_vessel1.07106192
58MP0005666_abnormal_adipose_tissue1.06764938
59MP0003045_fibrosis1.02058791
60MP0004808_abnormal_hematopoietic_stem1.01574484
61MP0004883_abnormal_blood_vessel1.00200548
62MP0005000_abnormal_immune_tolerance0.99853123
63MP0005025_abnormal_response_to0.98315720
64MP0000015_abnormal_ear_pigmentation0.96069424
65MP0003828_pulmonary_edema0.95888242
66MP0002723_abnormal_immune_serum0.94948169
67MP0003300_gastrointestinal_ulcer0.94128487
68MP0009384_cardiac_valve_regurgitation0.94014561
69MP0003724_increased_susceptibility_to0.93818946
70MP0009840_abnormal_foam_cell0.91298732
71MP0005083_abnormal_biliary_tract0.90715705
72MP0002060_abnormal_skin_morphology0.89540096
73MP0002933_joint_inflammation0.89406717
74MP0008057_abnormal_DNA_replication0.89112422
75MP0005275_abnormal_skin_tensile0.88973193
76MP0000377_abnormal_hair_follicle0.88316842
77MP0002896_abnormal_bone_mineralization0.87936339
78MP0005075_abnormal_melanosome_morpholog0.87418693
79MP0001533_abnormal_skeleton_physiology0.87170632
80MP0000733_abnormal_muscle_development0.86669936
81MP0002075_abnormal_coat/hair_pigmentati0.85661495
82MP0009931_abnormal_skin_appearance0.84373497
83MP0000427_abnormal_hair_cycle0.83902537
84MP0005248_abnormal_Harderian_gland0.82123473
85MP0003566_abnormal_cell_adhesion0.79876390
86MP0000678_abnormal_parathyroid_gland0.79475241
87MP0005621_abnormal_cell_physiology0.77380185
88MP0010771_integument_phenotype0.75607021
89MP0001819_abnormal_immune_cell0.74942902
90MP0001851_eye_inflammation0.74715505
91MP0004043_abnormal_pH_regulation0.73884069
92MP0002420_abnormal_adaptive_immunity0.73695203
93MP0001216_abnormal_epidermal_layer0.73302939
94MP0002971_abnormal_brown_adipose0.72448392
95MP0005334_abnormal_fat_pad0.72079316
96MP0005595_abnormal_vascular_smooth0.71707142
97MP0005023_abnormal_wound_healing0.71335367
98MP0003948_abnormal_gas_homeostasis0.68974768
99MP0005464_abnormal_platelet_physiology0.67754600
100MP0005448_abnormal_energy_balance0.67712977

Predicted human phenotypes

RankGene SetZ-score
1J-shaped sella turcica (HP:0002680)4.32491599
2Deformed sella turcica (HP:0002681)3.73796431
3Broad face (HP:0000283)3.60904692
4Abnormality of nail color (HP:0100643)3.51913651
5Sparse lateral eyebrow (HP:0005338)3.45115517
6Abnormality of the sella turcica (HP:0002679)3.22939003
7Cerebral aneurysm (HP:0004944)3.22256807
8Genetic anticipation (HP:0003743)3.16899633
9Abnormality of the fingertips (HP:0001211)3.15916587
10Hyperacusis (HP:0010780)3.00669840
11Increased cerebral lipofuscin (HP:0011813)2.99000769
12Increased neuronal autofluorescent lipopigment (HP:0002074)2.83131697
13Lip pit (HP:0100267)2.78889758
14Mucopolysacchariduria (HP:0008155)2.72185973
15Urinary glycosaminoglycan excretion (HP:0003541)2.72185973
16Colitis (HP:0002583)2.70766899
17Obstructive sleep apnea (HP:0002870)2.68647659
18Cervical subluxation (HP:0003308)2.68220049
19Absent frontal sinuses (HP:0002688)2.66362887
20Abnormality of mucopolysaccharide metabolism (HP:0011020)2.65517592
21Abnormality of polysaccharide metabolism (HP:0011012)2.65517592
22Abnormality of glycosaminoglycan metabolism (HP:0004371)2.65517592
23Parakeratosis (HP:0001036)2.53426828
24Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.46853424
25Narrow palate (HP:0000189)2.44104647
26Loss of speech (HP:0002371)2.43467500
27Dysostosis multiplex (HP:0000943)2.40632456
28Thin bony cortex (HP:0002753)2.39183955
29Increased IgE level (HP:0003212)2.38111384
30Glomerulonephritis (HP:0000099)2.28349623
31Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)2.27214999
32Flat acetabular roof (HP:0003180)2.26887478
33Long eyelashes (HP:0000527)2.26769211
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26491467
35Germ cell neoplasia (HP:0100728)2.18824896
36Abnormality of the epiphyses of the hand (HP:0005924)2.13036297
37Thick nail (HP:0001805)2.09086314
38Spinal cord lesions (HP:0100561)2.08690953
39Syringomyelia (HP:0003396)2.08690953
40Lymphangioma (HP:0100764)2.08549864
41Dysmetric saccades (HP:0000641)2.07643138
42Retrobulbar optic neuritis (HP:0100654)2.06268737
43Optic neuritis (HP:0100653)2.06268737
44Esophageal varix (HP:0002040)2.05602352
45Laryngomalacia (HP:0001601)2.05490781
46Abnormality of the thoracic spine (HP:0100711)2.00751901
47Urethral obstruction (HP:0000796)2.00012332
48Septate vagina (HP:0001153)1.97365913
49Nuclear cataract (HP:0100018)1.96399775
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.94669117
51Orchitis (HP:0100796)1.92793085
52Persistence of primary teeth (HP:0006335)1.91625347
53Distal lower limb amyotrophy (HP:0008944)1.88861203
54Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.88002400
55Concave nail (HP:0001598)1.87376387
56Macroorchidism (HP:0000053)1.85768578
57Distal lower limb muscle weakness (HP:0009053)1.85264590
58Autoimmune thrombocytopenia (HP:0001973)1.85196112
59Hemorrhage of the eye (HP:0011885)1.85002798
60Chronic mucocutaneous candidiasis (HP:0002728)1.82588356
61Recurrent cutaneous fungal infections (HP:0011370)1.82588356
62Deep philtrum (HP:0002002)1.82397590
63Neuronal loss in central nervous system (HP:0002529)1.81392726
64Abnormality of the radial head (HP:0003995)1.81122739
65Hypopigmentation of the fundus (HP:0007894)1.80930097
66Cone-rod dystrophy (HP:0000548)1.80251909
67Spondylolisthesis (HP:0003302)1.78841749
68Bilateral sensorineural hearing impairment (HP:0008619)1.77369070
69Ocular albinism (HP:0001107)1.73717259
70Recurrent bacterial skin infections (HP:0005406)1.72690864
71Long toe (HP:0010511)1.72489018
72Thick eyebrow (HP:0000574)1.71922755
73Hyperkalemia (HP:0002153)1.71482896
74Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.70466147
75Upper limb amyotrophy (HP:0009129)1.70213569
76Distal upper limb amyotrophy (HP:0007149)1.70213569
77Renovascular hypertension (HP:0100817)1.69403406
78Neonatal hypoglycemia (HP:0001998)1.68123673
79Dislocated radial head (HP:0003083)1.68099518
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67491191
81Ectropion (HP:0000656)1.67256868
82Asymmetry of the thorax (HP:0001555)1.65795542
83Thoracic kyphosis (HP:0002942)1.65382794
84Mediastinal lymphadenopathy (HP:0100721)1.64466336
85Abnormality of the columella (HP:0009929)1.63085584
86Smooth philtrum (HP:0000319)1.62503724
87Prominent nose (HP:0000448)1.61770289
88Natal tooth (HP:0000695)1.61348040
89Precocious puberty (HP:0000826)1.60434251
90Vitreoretinal degeneration (HP:0000655)1.59487762
91Abnormality of liposaccharide metabolism (HP:0010968)1.59202552
92Abnormality of glycosphingolipid metabolism (HP:0004343)1.59202552
93Abnormality of glycolipid metabolism (HP:0010969)1.59202552
94Hematochezia (HP:0002573)1.58247655
95Systemic lupus erythematosus (HP:0002725)1.57949209
96Advanced eruption of teeth (HP:0006288)1.56314508
97Neoplasm of the heart (HP:0100544)1.56011063
98Curly hair (HP:0002212)1.55677106
99Morphological abnormality of the middle ear (HP:0008609)1.55055034
100Slow saccadic eye movements (HP:0000514)1.54391423

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.90368573
2SIK13.75185717
3PKN23.31368567
4EPHA23.07670240
5BLK2.80919215
6CDK122.79068056
7AKT32.57040100
8CHUK2.00634131
9ICK1.85484502
10RIPK11.80939727
11CDC42BPA1.70935913
12CSF1R1.69747833
13ERN11.67880155
14TNK21.53641177
15MARK21.51370828
16MTOR1.48491219
17MAPK151.44224547
18IRAK31.44082298
19IKBKE1.39563594
20MUSK1.38326258
21MAPKAPK31.32184860
22RIPK41.30809637
23FRK1.28941163
24TGFBR21.28019205
25SGK21.27914171
26EEF2K1.27908013
27NEK61.23911584
28MAP4K11.20232462
29CAMK1D1.20078743
30SGK31.19491153
31CAMK1G1.16030840
32TBK11.07519040
33MAP3K71.07044458
34FGFR41.01870960
35RPS6KA21.01499143
36BMX0.97535707
37IKBKB0.95808618
38SIK20.92821238
39PDPK10.92336718
40JAK10.91114380
41PDGFRB0.87527459
42PIK3CA0.87262368
43MAP3K60.86514492
44ERBB20.86420823
45RET0.86370664
46PDK10.86203101
47MAP3K30.85830292
48PRKD20.83758582
49PIM20.81298815
50MAPK70.81241156
51RPS6KC10.79994491
52RPS6KL10.79994491
53PTK60.79461108
54MAP3K130.79025041
55BTK0.79024094
56FGR0.77779950
57PRPF4B0.74374471
58SGK4940.73032381
59SGK2230.73032381
60RPS6KA60.72821911
61HIPK20.72201704
62TYK20.70238476
63BMPR20.70237637
64BRD40.68641317
65MAP2K30.68183609
66MAP3K140.67812743
67SMG10.66994063
68PDGFRA0.66756332
69GRK60.66104076
70CSK0.64499090
71CDK60.64199001
72IRAK40.60088408
73HCK0.58043865
74TYRO30.57803741
75FER0.57748792
76TAOK10.56798568
77MAPK80.56701760
78PTK20.56101377
79TTN0.56039185
80TRPM70.55900919
81MAP3K100.53339022
82TXK0.53238621
83MATK0.52002577
84PRKAA20.50690566
85MELK0.49714962
86MAP3K10.48719276
87MAPK110.48543189
88JAK30.48064976
89DYRK1B0.47265188
90RPS6KB20.46347906
91MAPK100.45130777
92MAP2K40.44417403
93PRKAA10.43430174
94CAMK40.43068884
95IRAK20.43015535
96RPS6KA10.41842710
97MAPK10.41732571
98PRKD10.41462436
99IRAK10.41419047
100ITK0.41126239

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.82315494
2Other glycan degradation_Homo sapiens_hsa005112.23284688
3B cell receptor signaling pathway_Homo sapiens_hsa046621.80391777
4Notch signaling pathway_Homo sapiens_hsa043301.70239689
5Acute myeloid leukemia_Homo sapiens_hsa052211.69475026
6Osteoclast differentiation_Homo sapiens_hsa043801.59998177
7Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59331624
8Lysine degradation_Homo sapiens_hsa003101.55288424
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54627439
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46184169
11mTOR signaling pathway_Homo sapiens_hsa041501.42954458
12Staphylococcus aureus infection_Homo sapiens_hsa051501.38466219
13VEGF signaling pathway_Homo sapiens_hsa043701.37668718
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.37628287
15TNF signaling pathway_Homo sapiens_hsa046681.36045598
16Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.35530325
17Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.35221238
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.32969867
19Phosphatidylinositol signaling system_Homo sapiens_hsa040701.28057849
20Choline metabolism in cancer_Homo sapiens_hsa052311.27669778
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.25459713
22Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.24639429
23Longevity regulating pathway - mammal_Homo sapiens_hsa042111.22919604
24Chronic myeloid leukemia_Homo sapiens_hsa052201.22809978
25Non-small cell lung cancer_Homo sapiens_hsa052231.22669072
26ErbB signaling pathway_Homo sapiens_hsa040121.21806918
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.20224867
28Toxoplasmosis_Homo sapiens_hsa051451.18990437
29Estrogen signaling pathway_Homo sapiens_hsa049151.16539659
30RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15848207
31Hepatitis C_Homo sapiens_hsa051601.14284767
32Insulin resistance_Homo sapiens_hsa049311.13474356
33Prolactin signaling pathway_Homo sapiens_hsa049171.12717489
34Leishmaniasis_Homo sapiens_hsa051401.12548972
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10677462
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10590554
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.09934486
38Lysosome_Homo sapiens_hsa041421.09711408
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.08652375
40Endometrial cancer_Homo sapiens_hsa052131.07926459
41Inositol phosphate metabolism_Homo sapiens_hsa005621.07480326
42GnRH signaling pathway_Homo sapiens_hsa049121.06933989
43Influenza A_Homo sapiens_hsa051641.06857587
44Type II diabetes mellitus_Homo sapiens_hsa049301.06647891
45Renal cell carcinoma_Homo sapiens_hsa052111.03329533
46Dorso-ventral axis formation_Homo sapiens_hsa043201.02204423
47Platelet activation_Homo sapiens_hsa046111.01659331
48FoxO signaling pathway_Homo sapiens_hsa040680.99875103
49Tuberculosis_Homo sapiens_hsa051520.98518603
50Jak-STAT signaling pathway_Homo sapiens_hsa046300.98331698
51Pancreatic cancer_Homo sapiens_hsa052120.94965979
52Adipocytokine signaling pathway_Homo sapiens_hsa049200.94779406
53Bladder cancer_Homo sapiens_hsa052190.91739416
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91188706
55Insulin signaling pathway_Homo sapiens_hsa049100.89602611
56ABC transporters_Homo sapiens_hsa020100.89594448
57Hepatitis B_Homo sapiens_hsa051610.87755443
58Legionellosis_Homo sapiens_hsa051340.86263184
59Pertussis_Homo sapiens_hsa051330.85174775
60AMPK signaling pathway_Homo sapiens_hsa041520.84757910
61Glioma_Homo sapiens_hsa052140.83481973
62HIF-1 signaling pathway_Homo sapiens_hsa040660.82673885
63MicroRNAs in cancer_Homo sapiens_hsa052060.82426460
64Malaria_Homo sapiens_hsa051440.82286627
65T cell receptor signaling pathway_Homo sapiens_hsa046600.82016543
66Prostate cancer_Homo sapiens_hsa052150.81060735
67Leukocyte transendothelial migration_Homo sapiens_hsa046700.80456014
68Proteoglycans in cancer_Homo sapiens_hsa052050.80052504
69Chemokine signaling pathway_Homo sapiens_hsa040620.77755113
70Focal adhesion_Homo sapiens_hsa045100.75796309
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75012246
72Amoebiasis_Homo sapiens_hsa051460.73705079
73Small cell lung cancer_Homo sapiens_hsa052220.73511255
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.71936407
75Sphingolipid metabolism_Homo sapiens_hsa006000.71453578
76Carbohydrate digestion and absorption_Homo sapiens_hsa049730.70583289
77Colorectal cancer_Homo sapiens_hsa052100.69972937
78Ovarian steroidogenesis_Homo sapiens_hsa049130.68139594
79MAPK signaling pathway_Homo sapiens_hsa040100.67961189
80Systemic lupus erythematosus_Homo sapiens_hsa053220.66727411
81Rap1 signaling pathway_Homo sapiens_hsa040150.64682195
82Apoptosis_Homo sapiens_hsa042100.63658651
83Endocytosis_Homo sapiens_hsa041440.62966161
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.62743437
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60361493
86Viral carcinogenesis_Homo sapiens_hsa052030.59548147
87Measles_Homo sapiens_hsa051620.59527418
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55804701
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.54870886
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.54602703
91Thyroid cancer_Homo sapiens_hsa052160.54592718
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.50463856
93Aldosterone synthesis and secretion_Homo sapiens_hsa049250.50402297
94Axon guidance_Homo sapiens_hsa043600.50399660
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.49850368
96Circadian rhythm_Homo sapiens_hsa047100.48335246
97HTLV-I infection_Homo sapiens_hsa051660.48308727
98Cholinergic synapse_Homo sapiens_hsa047250.47798096
99African trypanosomiasis_Homo sapiens_hsa051430.46595320
100Herpes simplex infection_Homo sapiens_hsa051680.45595483

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