TNNT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)9.51052494
2* sarcomere organization (GO:0045214)9.47386758
3myofibril assembly (GO:0030239)8.30365104
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)8.05804313
5negative regulation of potassium ion transmembrane transport (GO:1901380)7.42699449
6cardiac muscle contraction (GO:0060048)7.27441910
7* actin-myosin filament sliding (GO:0033275)7.03974589
8* muscle filament sliding (GO:0030049)7.03974589
9cardiac muscle cell development (GO:0055013)6.96923990
10regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.71168175
11adult heart development (GO:0007512)6.70733516
12cardiac cell development (GO:0055006)6.55609609
13positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.38839224
14* cardiac muscle tissue morphogenesis (GO:0055008)6.30897760
15regulation of actin filament-based movement (GO:1903115)6.29641165
16* ventricular cardiac muscle tissue morphogenesis (GO:0055010)6.23553411
17regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.21401936
18cardiac muscle hypertrophy (GO:0003300)6.03210460
19ventricular cardiac muscle cell action potential (GO:0086005)6.03182253
20plasma membrane repair (GO:0001778)6.02101981
21* actomyosin structure organization (GO:0031032)5.98445573
22bundle of His cell to Purkinje myocyte communication (GO:0086069)5.95888752
23regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.91348298
24tricarboxylic acid cycle (GO:0006099)5.84552909
25* actin-mediated cell contraction (GO:0070252)5.84159771
26regulation of relaxation of muscle (GO:1901077)5.82585128
27striated muscle hypertrophy (GO:0014897)5.68617696
28regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.61386168
29* muscle tissue morphogenesis (GO:0060415)5.58691367
30regulation of sarcomere organization (GO:0060297)5.51814312
31striated muscle contraction (GO:0006941)5.46767708
32regulation of the force of heart contraction (GO:0002026)5.46436565
33heart trabecula formation (GO:0060347)5.46018453
34regulation of cardioblast differentiation (GO:0051890)5.40552017
35heart contraction (GO:0060047)5.36051281
36heart process (GO:0003015)5.36051281
37regulation of skeletal muscle contraction (GO:0014819)5.33700402
38detection of calcium ion (GO:0005513)5.24667885
39regulation of striated muscle contraction (GO:0006942)5.17199052
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.11932143
41muscle hypertrophy (GO:0014896)5.04272486
42negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.01877094
43cell communication involved in cardiac conduction (GO:0086065)4.87175355
44regulation of membrane repolarization (GO:0060306)4.71449386
45regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.70577101
46striated muscle atrophy (GO:0014891)4.67182599
47negative regulation of striated muscle cell apoptotic process (GO:0010664)4.64264297
48carnitine shuttle (GO:0006853)4.63285991
49regulation of cell communication by electrical coupling (GO:0010649)4.57676808
50regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.49428042
51cell communication by electrical coupling (GO:0010644)4.40787981
52* actin filament-based movement (GO:0030048)4.40639222
53cardiac muscle hypertrophy in response to stress (GO:0014898)4.36031226
54muscle hypertrophy in response to stress (GO:0003299)4.36031226
55cardiac muscle adaptation (GO:0014887)4.36031226
56regulation of cardiac muscle contraction (GO:0055117)4.35806619
57mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.34354392
58cellular response to epinephrine stimulus (GO:0071872)4.32007502
59regulation of heart rate (GO:0002027)4.31680489
60negative regulation of protein localization to cell surface (GO:2000009)4.28727120
61regulation of cardiac muscle cell contraction (GO:0086004)4.28249428
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.24868377
63sarcoplasmic reticulum calcium ion transport (GO:0070296)4.20831427
64cardiac muscle cell action potential involved in contraction (GO:0086002)4.18961636
65muscle atrophy (GO:0014889)4.18868545
66cardiac muscle cell action potential (GO:0086001)4.15976882
67cardiac chamber formation (GO:0003207)4.10308760
68response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.09689420
69response to epinephrine (GO:0071871)4.08306518
70negative regulation of potassium ion transport (GO:0043267)4.08117756
71regulation of acyl-CoA biosynthetic process (GO:0050812)4.07900638
72ATP synthesis coupled proton transport (GO:0015986)4.07046202
73energy coupled proton transport, down electrochemical gradient (GO:0015985)4.07046202
74ventricular cardiac muscle cell development (GO:0055015)4.06066826
75striated muscle adaptation (GO:0014888)4.03500089
76adrenergic receptor signaling pathway (GO:0071875)3.97795436
77membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94032692
78fatty acid transmembrane transport (GO:1902001)3.92858829
79response to caffeine (GO:0031000)3.89271287
80* regulation of heart contraction (GO:0008016)3.88551045
81positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.85115795
82* positive regulation of ATP catabolic process (GO:1903291)3.84525004
83* positive regulation of ATPase activity (GO:0032781)3.84525004
84* regulation of ATPase activity (GO:0043462)3.79995870
85* regulation of ATP catabolic process (GO:1903289)3.79995870
86striated muscle cell development (GO:0055002)3.79330536
87relaxation of cardiac muscle (GO:0055119)3.77731604
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.76610807
89atrial septum morphogenesis (GO:0060413)3.75869911
90regulation of coenzyme metabolic process (GO:0051196)3.74913252
91regulation of cofactor metabolic process (GO:0051193)3.74913252
92muscle system process (GO:0003012)3.69986467
93oxygen transport (GO:0015671)3.67944769
94regulation of striated muscle cell apoptotic process (GO:0010662)3.64752247
95cardiac conduction (GO:0061337)3.62402603
96positive regulation of heart contraction (GO:0045823)3.62097860
97regulation of heart rate by cardiac conduction (GO:0086091)3.59999325
98positive regulation of heart rate (GO:0010460)3.59036693
99respiratory electron transport chain (GO:0022904)3.58584046
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57835446
101trabecula formation (GO:0060343)3.55145614
102oxidative phosphorylation (GO:0006119)3.49699077
103* regulation of muscle system process (GO:0090257)3.48001479
104NADH metabolic process (GO:0006734)3.47783603
105electron transport chain (GO:0022900)3.47667459
106skeletal muscle adaptation (GO:0043501)3.46915721
107negative regulation of cytosolic calcium ion concentration (GO:0051481)3.45338627
108muscle contraction (GO:0006936)3.39933362
109carnitine transmembrane transport (GO:1902603)3.38315058
110positive regulation of cation channel activity (GO:2001259)3.36098781
1112-oxoglutarate metabolic process (GO:0006103)3.35943976
112positive regulation of action potential (GO:0045760)3.35514754
113cardiac ventricle formation (GO:0003211)3.35000891
114calcium-mediated signaling using intracellular calcium source (GO:0035584)3.34574350
115* regulation of muscle contraction (GO:0006937)3.33904561
116regulation of calcium ion transmembrane transporter activity (GO:1901019)3.32759360
117regulation of calcium ion transmembrane transport (GO:1903169)3.32759360
118cardiac muscle tissue development (GO:0048738)3.30817732
119atrioventricular valve morphogenesis (GO:0003181)3.29631204
120response to inactivity (GO:0014854)3.28977364
121muscle adaptation (GO:0043500)3.28289314
122neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.27669714
123response to redox state (GO:0051775)3.23054220
124outflow tract septum morphogenesis (GO:0003148)3.18499645

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.10429023
2* EP300_21415370_ChIP-Seq_HL-1_Mouse5.41504228
3* TBX20_22080862_ChIP-Seq_HEART_Mouse4.24860825
4* TBX20_22328084_ChIP-Seq_HEART_Mouse4.24860825
5ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.18964441
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.09893745
7TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.37632033
8* MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.35451263
9ESR1_20079471_ChIP-ChIP_T-47D_Human3.21252890
10ZNF263_19887448_ChIP-Seq_K562_Human3.03792133
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.93692112
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.79851439
13EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.70770441
14GATA4_21415370_ChIP-Seq_HL-1_Mouse2.61019778
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.15421339
16BP1_19119308_ChIP-ChIP_Hs578T_Human2.12801080
17EZH2_22144423_ChIP-Seq_EOC_Human2.11467297
18NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.08291061
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.06378127
20VDR_22108803_ChIP-Seq_LS180_Human2.03976192
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.98476746
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.95733512
23NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.89242739
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.83808793
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.79085661
26CLOCK_20551151_ChIP-Seq_293T_Human1.69595972
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.69141896
28FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.67718421
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.62494720
30* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.62304964
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.58842480
32PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.55715206
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.50873769
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.50020189
35ISL1_27105846_Chip-Seq_CPCs_Mouse1.48387677
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.46537828
37SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.44595138
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.43626423
39* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41096771
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39965649
41CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.37991302
42HTT_18923047_ChIP-ChIP_STHdh_Human1.37737473
43GATA2_21666600_ChIP-Seq_HMVEC_Human1.34056202
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.33431413
45ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.33185253
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29884933
47DROSHA_22980978_ChIP-Seq_HELA_Human1.28982226
48GATA1_19941826_ChIP-Seq_K562_Human1.27473007
49HIF1A_21447827_ChIP-Seq_MCF-7_Human1.26344582
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24989612
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.24454346
52* KDM2B_26808549_Chip-Seq_DND41_Human1.24138867
53RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23261139
54SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22396383
55CTCF_27219007_Chip-Seq_Bcells_Human1.22270139
56GBX2_23144817_ChIP-Seq_PC3_Human1.21657441
57SMAD4_21799915_ChIP-Seq_A2780_Human1.21447411
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21141116
59PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20021528
60* TP63_22573176_ChIP-Seq_HFKS_Human1.19875266
61TP53_16413492_ChIP-PET_HCT116_Human1.18735281
62LXR_22292898_ChIP-Seq_THP-1_Human1.15066862
63NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12363619
64LXR_22158963_ChIP-Seq_LIVER_Mouse1.12193282
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.12090398
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.12090398
67ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11087882
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.09191170
69TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09113882
70* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08302255
71SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07877611
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.07860204
73BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07415419
74RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07078337
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.06415344
76MTF2_20144788_ChIP-Seq_MESCs_Mouse1.05899118
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.05632578
78RACK7_27058665_Chip-Seq_MCF-7_Human1.05563389
79NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04607164
80NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04566617
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04489278
82EED_16625203_ChIP-ChIP_MESCs_Mouse1.02704438
83IGF1R_20145208_ChIP-Seq_DFB_Human1.02264114
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.01754913
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01244829
86DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00158617
87* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.99174442
88ATF3_27146783_Chip-Seq_COLON_Human0.99000325
89TP53_23651856_ChIP-Seq_MEFs_Mouse0.97417816
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97295998
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97191479
92* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97063364
93TBL1_22424771_ChIP-Seq_293T_Human0.97041197
94* NFE2_27457419_Chip-Seq_LIVER_Mouse0.96563035
95NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96547321
96NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96547321
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96508860
98SMC3_22415368_ChIP-Seq_MEFs_Mouse0.95680649
99AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.95590987
100SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.95378989
101* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95211603
102E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.94084313
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93433617
104* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92649677
105SPI1_20517297_ChIP-Seq_HL60_Human0.92539572
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.92531821
107WT1_25993318_ChIP-Seq_PODOCYTE_Human0.92230694
108STAT3_1855785_ChIP-Seq_MESCs_Mouse0.92209507
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.91006552
110BCAT_22108803_ChIP-Seq_LS180_Human0.90890399
111UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.90764089
112OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90698127
113SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90409354
114* EZH2_27294783_Chip-Seq_NPCs_Mouse0.90336071
115* FOXA2_19822575_ChIP-Seq_HepG2_Human0.89819640
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89615677
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.88046339
118SMAD3_21741376_ChIP-Seq_EPCs_Human0.88024612
119GATA2_19941826_ChIP-Seq_K562_Human0.87572663
120SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86974389
121SPI1_23127762_ChIP-Seq_K562_Human0.86423163
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.86421231
123STAT3_18555785_ChIP-Seq_MESCs_Mouse0.85325935
124SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.84338533
125TCF4_23295773_ChIP-Seq_U87_Human0.83974600
126KDM2B_26808549_Chip-Seq_K562_Human0.83898359
127SMAD_19615063_ChIP-ChIP_OVARY_Human0.83864197
128* PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.83830738
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83810409
130CJUN_26792858_Chip-Seq_BT549_Human0.82887622
131GF1_26923725_Chip-Seq_HPCs_Mouse0.82697440
132P68_20966046_ChIP-Seq_HELA_Human0.82621494
133GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80269182
134* STAT3_23295773_ChIP-Seq_U87_Human0.80110921
135HNFA_21074721_ChIP-Seq_CACO-2_Human0.79297051
136* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.78667321
137EZH2_27304074_Chip-Seq_ESCs_Mouse0.76890396
138AUTS2_25519132_ChIP-Seq_293T-REX_Human0.76448413
139AHR_22903824_ChIP-Seq_MCF-7_Human0.76090129
140MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76037607
141ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.75563139
142GATA1_22025678_ChIP-Seq_K562_Human0.75509970
143LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75288365
144* SMAD4_21741376_ChIP-Seq_HESCs_Human0.75275411
145ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75233261
146BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.75137320
147WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.74957641
148FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.74605290
149GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74102033
150SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73551218
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72798744
152GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.72344908
153BCL6_27268052_Chip-Seq_Bcells_Human0.71252041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.39633525
2MP0004084_abnormal_cardiac_muscle6.41224108
3MP0000751_myopathy5.06479221
4MP0003646_muscle_fatigue5.02812301
5* MP0004215_abnormal_myocardial_fiber4.66490477
6MP0004036_abnormal_muscle_relaxation4.44120318
7MP0005330_cardiomyopathy4.15663164
8MP0000749_muscle_degeneration3.80646352
9* MP0002972_abnormal_cardiac_muscle3.32628767
10* MP0004087_abnormal_muscle_fiber3.01106506
11* MP0003137_abnormal_impulse_conducting2.94576468
12MP0006138_congestive_heart_failure2.73397096
13* MP0005385_cardiovascular_system_phenoty2.73172321
14* MP0001544_abnormal_cardiovascular_syste2.73172321
15* MP0010630_abnormal_cardiac_muscle2.73057438
16MP0000750_abnormal_muscle_regeneration2.67990909
17* MP0008775_abnormal_heart_ventricle2.66278057
18* MP0005620_abnormal_muscle_contractility2.64071379
19MP0003828_pulmonary_edema2.61526694
20MP0002106_abnormal_muscle_physiology2.39102150
21MP0004484_altered_response_of2.33605295
22* MP0004085_abnormal_heartbeat2.23693848
23MP0002269_muscular_atrophy2.21789149
24MP0004510_myositis2.13391432
25MP0004130_abnormal_muscle_cell2.05775972
26MP0003221_abnormal_cardiomyocyte_apopto2.01055280
27MP0005369_muscle_phenotype1.94236145
28MP0002127_abnormal_cardiovascular_syste1.89690838
29MP0003950_abnormal_plasma_membrane1.83165231
30MP0004145_abnormal_muscle_electrophysio1.80939475
31MP0000759_abnormal_skeletal_muscle1.77272930
32MP0000747_muscle_weakness1.72422825
33MP0004233_abnormal_muscle_weight1.67872738
34MP0003567_abnormal_fetal_cardiomyocyte1.62337630
35MP0006036_abnormal_mitochondrial_physio1.41687912
36MP0003279_aneurysm1.36248734
37MP0010368_abnormal_lymphatic_system1.32973517
38* MP0000266_abnormal_heart_morphology1.22501065
39MP0005666_abnormal_adipose_tissue1.19597217
40MP0002332_abnormal_exercise_endurance1.18988796
41MP0002234_abnormal_pharynx_morphology1.18207927
42MP0005670_abnormal_white_adipose1.16456148
43MP0008004_abnormal_stomach_pH1.12851073
44MP0000343_altered_response_to1.11179189
45MP0005623_abnormal_meninges_morphology1.08713560
46MP0005165_increased_susceptibility_to1.03366453
47MP0003566_abnormal_cell_adhesion0.99959875
48MP0002128_abnormal_blood_circulation0.92678114
49MP0005451_abnormal_body_composition0.88480580
50MP0004272_abnormal_basement_membrane0.85824545
51MP0000767_abnormal_smooth_muscle0.83438571
52MP0006035_abnormal_mitochondrial_morpho0.83169627
53MP0005375_adipose_tissue_phenotype0.80035448
54MP0000230_abnormal_systemic_arterial0.79352416
55MP0002108_abnormal_muscle_morphology0.79060841
56MP0003705_abnormal_hypodermis_morpholog0.78471359
57MP0004185_abnormal_adipocyte_glucose0.71320011
58MP0005266_abnormal_metabolism0.71311764
59MP0001879_abnormal_lymphatic_vessel0.69346883
60MP0001661_extended_life_span0.60255823
61MP0008438_abnormal_cutaneous_collagen0.59882387
62MP0009384_cardiac_valve_regurgitation0.58816593
63* MP0002925_abnormal_cardiovascular_devel0.57067930
64MP0002909_abnormal_adrenal_gland0.56088190
65MP0000733_abnormal_muscle_development0.55694492
66MP0003806_abnormal_nucleotide_metabolis0.52519460
67MP0002102_abnormal_ear_morphology0.49486321
68* MP0003984_embryonic_growth_retardation0.48346523
69* MP0002088_abnormal_embryonic_growth/wei0.47337359
70MP0009840_abnormal_foam_cell0.46374162
71MP0000003_abnormal_adipose_tissue0.45879527
72MP0005187_abnormal_penis_morphology0.45681466
73MP0001614_abnormal_blood_vessel0.45413784
74* MP0001784_abnormal_fluid_regulation0.43688099
75MP0005319_abnormal_enzyme/_coenzyme0.41355769
76MP0005503_abnormal_tendon_morphology0.38747724
77MP0002254_reproductive_system_inflammat0.38020288
78MP0005275_abnormal_skin_tensile0.37974234
79MP0003941_abnormal_skin_development0.36542498
80MP0004043_abnormal_pH_regulation0.36102610
81MP0000013_abnormal_adipose_tissue0.35925320
82MP0001299_abnormal_eye_distance/0.34799482
83MP0006072_abnormal_retinal_apoptosis0.34643602
84MP0005595_abnormal_vascular_smooth0.34549847
85MP0003948_abnormal_gas_homeostasis0.33916730
86MP0002971_abnormal_brown_adipose0.33157755
87MP0002078_abnormal_glucose_homeostasis0.32248891
88MP0001984_abnormal_olfaction0.30399452
89MP0005388_respiratory_system_phenotype0.28538529
90MP0002133_abnormal_respiratory_system0.28538529
91MP0001958_emphysema0.27991422
92MP0002295_abnormal_pulmonary_circulatio0.27708493
93MP0008961_abnormal_basal_metabolism0.27522407
94* MP0005380_embryogenesis_phenotype0.26975573
95* MP0001672_abnormal_embryogenesis/_devel0.26975573
96MP0000762_abnormal_tongue_morphology0.23708931
97MP0000249_abnormal_blood_vessel0.22734554
98MP0001727_abnormal_embryo_implantation0.22582089
99MP0004147_increased_porphyrin_level0.22010999
100MP0002090_abnormal_vision0.21474080
101MP0009780_abnormal_chondrocyte_physiolo0.21190838
102MP0005167_abnormal_blood-brain_barrier0.19562877
103MP0004924_abnormal_behavior0.19146511
104MP0005386_behavior/neurological_phenoty0.19146511
105MP0008569_lethality_at_weaning0.18796368
106MP0004270_analgesia0.17921825
107MP0000462_abnormal_digestive_system0.17829232
108MP0003935_abnormal_craniofacial_develop0.17280555
109MP0005535_abnormal_body_temperature0.17091210
110MP0009115_abnormal_fat_cell0.16709182
111MP0005253_abnormal_eye_physiology0.16703327
112MP0003385_abnormal_body_wall0.16316725
113MP0003045_fibrosis0.16211980
114MP0005377_hearing/vestibular/ear_phenot0.15771420
115MP0001175_abnormal_lung_morphology0.15458935
116MP0005584_abnormal_enzyme/coenzyme_acti0.14315662
117MP0008874_decreased_physiological_sensi0.11871196

Predicted human phenotypes

RankGene SetZ-score
1* Sudden death (HP:0001699)8.51373733
2Ventricular tachycardia (HP:0004756)7.61023403
3Calf muscle hypertrophy (HP:0008981)6.34971874
4* Atrial fibrillation (HP:0005110)6.34222239
5Abnormality of the left ventricular outflow tract (HP:0011103)6.12594302
6Subaortic stenosis (HP:0001682)6.12594302
7* Primary atrial arrhythmia (HP:0001692)5.91655817
8Muscle fiber splitting (HP:0003555)5.83972007
9* Lipoatrophy (HP:0100578)5.82050666
10* Supraventricular tachycardia (HP:0004755)5.71745339
11Abnormality of the calf musculature (HP:0001430)5.68314650
12Muscle hypertrophy of the lower extremities (HP:0008968)5.63517256
13Right ventricular cardiomyopathy (HP:0011663)5.61979220
14* Supraventricular arrhythmia (HP:0005115)5.61976215
15Exercise-induced muscle cramps (HP:0003710)5.47694778
16Syncope (HP:0001279)5.28517190
17Exercise-induced myalgia (HP:0003738)5.15673618
18Hyporeflexia of lower limbs (HP:0002600)5.06423777
19Prolonged QT interval (HP:0001657)4.84725246
20* Dilated cardiomyopathy (HP:0001644)4.69757871
21Palpitations (HP:0001962)4.68928104
22Bundle branch block (HP:0011710)4.63271722
23Ventricular arrhythmia (HP:0004308)4.53378115
24Asymmetric septal hypertrophy (HP:0001670)4.52155459
25EMG: myopathic abnormalities (HP:0003458)4.40950314
26Ventricular fibrillation (HP:0001663)4.12922336
27Myoglobinuria (HP:0002913)4.11227862
28Atrioventricular block (HP:0001678)4.02630783
29Heart block (HP:0012722)3.99584671
30Abnormal atrioventricular conduction (HP:0005150)3.77739792
31Increased connective tissue (HP:0009025)3.77215120
32Abnormal EKG (HP:0003115)3.49171825
33Myotonia (HP:0002486)3.24019076
34Rhabdomyolysis (HP:0003201)3.09547149
35Difficulty running (HP:0009046)3.07657302
36Aplasia of the musculature (HP:0100854)2.95212957
37Popliteal pterygium (HP:0009756)2.94496904
38Bradycardia (HP:0001662)2.91262806
39Ragged-red muscle fibers (HP:0003200)2.89757179
40Difficulty climbing stairs (HP:0003551)2.84907605
41* Palmoplantar keratoderma (HP:0000982)2.84791737
42Type 2 muscle fiber atrophy (HP:0003554)2.80203589
43* Left ventricular hypertrophy (HP:0001712)2.77136824
44Abnormal mitochondria in muscle tissue (HP:0008316)2.73857766
45Acute necrotizing encephalopathy (HP:0006965)2.72245704
46Hepatic necrosis (HP:0002605)2.70081023
47Rimmed vacuoles (HP:0003805)2.52146902
48Muscle fiber atrophy (HP:0100295)2.47744377
49Neck muscle weakness (HP:0000467)2.47130976
50Ketoacidosis (HP:0001993)2.46518480
51Type 1 muscle fiber predominance (HP:0003803)2.46097966
52Hypoplastic left heart (HP:0004383)2.44071501
53Abnormality of the neuromuscular junction (HP:0003398)2.43950464
54Fatigable weakness (HP:0003473)2.43950464
55Distal lower limb muscle weakness (HP:0009053)2.42283229
56Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.41079410
57Testicular atrophy (HP:0000029)2.40506500
58Mildly elevated creatine phosphokinase (HP:0008180)2.39893115
59Abnormality of the foot musculature (HP:0001436)2.39407352
60Sudden cardiac death (HP:0001645)2.36400016
61Limb-girdle muscle atrophy (HP:0003797)2.35524553
62Hepatocellular necrosis (HP:0001404)2.35371613
63Double outlet right ventricle (HP:0001719)2.34745169
64Congenital malformation of the right heart (HP:0011723)2.34745169
65Hypoglycemic coma (HP:0001325)2.34041475
66Acute encephalopathy (HP:0006846)2.30123290
67Conjunctival hamartoma (HP:0100780)2.28321756
68Centrally nucleated skeletal muscle fibers (HP:0003687)2.25421472
69Mitochondrial inheritance (HP:0001427)2.22412423
70Increased variability in muscle fiber diameter (HP:0003557)2.21486181
71Progressive macrocephaly (HP:0004481)2.21090643
72Weak cry (HP:0001612)2.14416354
73Muscle fiber inclusion bodies (HP:0100299)2.13151681
74Hip contracture (HP:0003273)2.13148446
75Areflexia of lower limbs (HP:0002522)2.12214755
76EMG: neuropathic changes (HP:0003445)2.11616160
77Cerebral edema (HP:0002181)2.10366205
78Nemaline bodies (HP:0003798)2.08904506
79Pheochromocytoma (HP:0002666)2.08878129
80Pulmonary artery stenosis (HP:0004415)2.08819680
81Steppage gait (HP:0003376)2.08361506
82Increased CSF lactate (HP:0002490)2.07695242
83Amniotic constriction ring (HP:0009775)2.07499490
84Abnormality of placental membranes (HP:0011409)2.07499490
85Respiratory insufficiency due to muscle weakness (HP:0002747)2.06925666
86Increased muscle lipid content (HP:0009058)2.06535744
87Dysmetric saccades (HP:0000641)2.05664293
88Abnormality of dicarboxylic acid metabolism (HP:0010995)2.05059447
89Dicarboxylic aciduria (HP:0003215)2.05059447
90Abnormality of fatty-acid metabolism (HP:0004359)2.04852617
91* Congestive heart failure (HP:0001635)2.04533585
92Foot dorsiflexor weakness (HP:0009027)2.04337168
93Generalized muscle weakness (HP:0003324)2.01978329
94Abnormality of the tricuspid valve (HP:0001702)2.00591237
95Hypoplastic heart (HP:0001961)2.00440015
96Distal lower limb amyotrophy (HP:0008944)2.00297212
97Exercise intolerance (HP:0003546)1.97325137
98Neoplasm of the adrenal gland (HP:0100631)1.96405453
99Abnormality of skeletal muscle fiber size (HP:0012084)1.96317919
100Bulbar palsy (HP:0001283)1.95802312
101Scapular winging (HP:0003691)1.95649582
102Nausea (HP:0002018)1.92785800
103Frequent falls (HP:0002359)1.92274065
104Easy fatigability (HP:0003388)1.90133568
105Muscle stiffness (HP:0003552)1.89890535
106Gowers sign (HP:0003391)1.89554728
107Muscular dystrophy (HP:0003560)1.89450420
108Respiratory failure (HP:0002878)1.88563541
109Hamartoma of the eye (HP:0010568)1.87778497
110Hypoplastic ischia (HP:0003175)1.83930047
111Neuroendocrine neoplasm (HP:0100634)1.83292477
112Fetal akinesia sequence (HP:0001989)1.82817633
113Lactic acidosis (HP:0003128)1.81513629
114Resting tremor (HP:0002322)1.81507560
115Abnormality of the shoulder girdle musculature (HP:0001435)1.81079058
116Increased intramyocellular lipid droplets (HP:0012240)1.80483215
117Large for gestational age (HP:0001520)1.79419096
118Diaphragmatic weakness (HP:0009113)1.78600317
119Patent foramen ovale (HP:0001655)1.77963161
120Lymphangioma (HP:0100764)1.77444960
121Skin nodule (HP:0200036)1.76419149
122Abnormality of the endocardium (HP:0004306)1.74973302
123Ketosis (HP:0001946)1.74601991
124Generalized aminoaciduria (HP:0002909)1.74573189
125Round ear (HP:0100830)1.73597931
126Increased serum pyruvate (HP:0003542)1.73545792
127Hyperinsulinemic hypoglycemia (HP:0000825)1.73331256
128Esophageal neoplasm (HP:0100751)1.73308852
129Neoplasm of head and neck (HP:0012288)1.73308852
130Thin ribs (HP:0000883)1.73273835
131Proximal tubulopathy (HP:0000114)1.70579809
132Aneurysm (HP:0002617)1.69586951
133Renal cortical cysts (HP:0000803)1.67619793
134Aplasia/Hypoplasia involving the musculature (HP:0001460)1.67444554
135Abnormality of glycolysis (HP:0004366)1.59927025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.42558839
2MYLK4.80184713
3LMTK24.22321678
4OBSCN4.18617898
5PHKG13.59074257
6PHKG23.59074257
7DMPK3.41243702
8PKN23.34073734
9PDK42.91575647
10PDK32.91575647
11PIK3CA2.86004564
12TRIB32.72284092
13MUSK2.56084586
14STK242.48471532
15TIE12.23165725
16BCKDK2.13517729
17NEK11.99883722
18PAK31.73156282
19PDK21.66438562
20CDC42BPA1.58655967
21ILK1.53213579
22LIMK11.51980686
23PINK11.49781511
24PRKD11.47641205
25CAMK2D1.37380053
26ZAK1.36856260
27WNK41.31924645
28ROCK11.28505529
29STK41.25754024
30DAPK31.22139213
31GRK71.14338862
32RIPK11.10272672
33STK38L1.09074221
34PIK3CG1.06261117
35TRPM70.94949197
36MAPK120.94416207
37FLT30.93407654
38MAPKAPK30.92355433
39MAP3K60.88459512
40PKN10.88338657
41MARK10.87336046
42INSRR0.85855974
43PDGFRA0.84638997
44PRKAA10.84159546
45MAP3K70.83078250
46ROCK20.81703318
47PTK2B0.78855898
48PRKAA20.77554126
49CCNB10.72812462
50RPS6KL10.72165632
51RPS6KC10.72165632
52WNK10.72012801
53CAMK40.71850633
54MAPK40.71155547
55EPHA30.70656099
56STK380.69080219
57TAOK10.68392730
58KDR0.68211950
59DDR20.66588015
60CAMK2A0.63892782
61TGFBR20.62531631
62RPS6KA60.61888112
63ICK0.60840650
64CAMK10.59589883
65MAP3K30.57692582
66EPHB10.55485522
67PRKACB0.55161670
68PRKCE0.54784151
69CAMK2B0.54707388
70MAP2K30.51945951
71PLK40.50703228
72MAP2K10.45398007
73EPHB20.44413603
74SIK10.43874720
75PRKACA0.40899196
76PRKACG0.40068504
77STK390.37753128
78PTK60.36029797
79PRKG20.34782268
80PRKD30.34161797
81ITK0.33193157
82MAP3K100.32258597
83MTOR0.31306197
84AKT20.31033144
85PRKCH0.31006208
86PDPK10.29803420
87RAF10.27531297
88LATS20.27128780
89FER0.26748378
90MAPK100.25300118
91RPS6KA10.25035385
92CAMK2G0.24928037
93LATS10.24776600
94PDK10.21941983
95PRKG10.21654831
96TGFBR10.20256528
97ADRBK10.19380508
98RPS6KA20.18330275
99PAK20.17519255
100LRRK20.17490678
101KSR20.17331454
102SGK30.16963841
103STK110.16128685
104ERBB30.15606764
105RET0.15460247
106NEK90.15229502
107MAPKAPK20.15149593
108JAK10.14823973
109MAPK70.13991634
110RPS6KA30.13877470
111SGK20.13422171
112PRKCD0.12751628
113PTK20.12513303
114PDGFRB0.12057426
115PRKD20.11821383
116UHMK10.10717745
117SGK10.09447150
118MARK20.09166422
119PRKCQ0.09123993
120NME20.05807980
121PAK60.05330209
122AKT10.04777118

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.72490314
2* Cardiac muscle contraction_Homo sapiens_hsa042604.72129708
3* Dilated cardiomyopathy_Homo sapiens_hsa054144.22773366
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.20882931
5* Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.11412790
6Parkinsons disease_Homo sapiens_hsa050123.25102040
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.24587933
8Oxidative phosphorylation_Homo sapiens_hsa001903.13528298
9Propanoate metabolism_Homo sapiens_hsa006402.85686171
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.68777865
11Fatty acid degradation_Homo sapiens_hsa000712.60358315
12Carbon metabolism_Homo sapiens_hsa012002.35951011
13Alzheimers disease_Homo sapiens_hsa050102.35913092
14Viral myocarditis_Homo sapiens_hsa054162.18307596
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14021922
16Huntingtons disease_Homo sapiens_hsa050162.05339979
17Fatty acid metabolism_Homo sapiens_hsa012121.95883174
18* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.93442484
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.91683320
20Pyruvate metabolism_Homo sapiens_hsa006201.64096316
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34886204
22Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22047109
23Butanoate metabolism_Homo sapiens_hsa006501.15970165
24cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14953987
25Fatty acid elongation_Homo sapiens_hsa000621.14499520
26Biosynthesis of amino acids_Homo sapiens_hsa012301.14171208
27Insulin resistance_Homo sapiens_hsa049311.01051776
28Glucagon signaling pathway_Homo sapiens_hsa049220.99190689
29PPAR signaling pathway_Homo sapiens_hsa033200.98200413
30Focal adhesion_Homo sapiens_hsa045100.90600361
31Lysine degradation_Homo sapiens_hsa003100.88628043
32Adipocytokine signaling pathway_Homo sapiens_hsa049200.86653256
33Starch and sucrose metabolism_Homo sapiens_hsa005000.86624128
34Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.82019368
35Tight junction_Homo sapiens_hsa045300.80295810
36Insulin signaling pathway_Homo sapiens_hsa049100.80179207
37HIF-1 signaling pathway_Homo sapiens_hsa040660.77572234
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77180604
39Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76919545
40Tryptophan metabolism_Homo sapiens_hsa003800.73081189
41ECM-receptor interaction_Homo sapiens_hsa045120.69500701
42Calcium signaling pathway_Homo sapiens_hsa040200.68514075
43Vascular smooth muscle contraction_Homo sapiens_hsa042700.67135803
44Arginine biosynthesis_Homo sapiens_hsa002200.66788459
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65501859
46Type II diabetes mellitus_Homo sapiens_hsa049300.63860318
47Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63722101
48Morphine addiction_Homo sapiens_hsa050320.63104741
49AMPK signaling pathway_Homo sapiens_hsa041520.58796211
50Oxytocin signaling pathway_Homo sapiens_hsa049210.58536582
51beta-Alanine metabolism_Homo sapiens_hsa004100.57481243
52Adherens junction_Homo sapiens_hsa045200.55295217
53Arginine and proline metabolism_Homo sapiens_hsa003300.55236865
54Galactose metabolism_Homo sapiens_hsa000520.52216634
55Amphetamine addiction_Homo sapiens_hsa050310.51777099
56Central carbon metabolism in cancer_Homo sapiens_hsa052300.51706773
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50842815
58Phenylalanine metabolism_Homo sapiens_hsa003600.49364022
59cAMP signaling pathway_Homo sapiens_hsa040240.49052146
60Amoebiasis_Homo sapiens_hsa051460.47475059
61Cocaine addiction_Homo sapiens_hsa050300.46497137
62Mineral absorption_Homo sapiens_hsa049780.44095570
63Fatty acid biosynthesis_Homo sapiens_hsa000610.43392301
64Renin secretion_Homo sapiens_hsa049240.42630787
65Protein digestion and absorption_Homo sapiens_hsa049740.42057152
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40823723
67GABAergic synapse_Homo sapiens_hsa047270.40264794
68Salivary secretion_Homo sapiens_hsa049700.39282584
69Fructose and mannose metabolism_Homo sapiens_hsa000510.38807747
70Insulin secretion_Homo sapiens_hsa049110.38409019
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.36183441
72Thyroid hormone synthesis_Homo sapiens_hsa049180.35693900
73Peroxisome_Homo sapiens_hsa041460.32560965
74Gastric acid secretion_Homo sapiens_hsa049710.32284925
75Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32093176
76Circadian entrainment_Homo sapiens_hsa047130.30514099
77Phospholipase D signaling pathway_Homo sapiens_hsa040720.30390841
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30381403
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.30314977
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30026505
81Proteoglycans in cancer_Homo sapiens_hsa052050.29422238
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.28954406
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.28359173
84Prion diseases_Homo sapiens_hsa050200.22744840
85Long-term potentiation_Homo sapiens_hsa047200.22555341
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20206414
87Ovarian steroidogenesis_Homo sapiens_hsa049130.20152537
88Metabolic pathways_Homo sapiens_hsa011000.19102120
89Platelet activation_Homo sapiens_hsa046110.18863306
90Renal cell carcinoma_Homo sapiens_hsa052110.18715014
91MAPK signaling pathway_Homo sapiens_hsa040100.18417708
92Linoleic acid metabolism_Homo sapiens_hsa005910.16982468
93Tyrosine metabolism_Homo sapiens_hsa003500.16857493
94Sulfur relay system_Homo sapiens_hsa041220.16819218
95Glutamatergic synapse_Homo sapiens_hsa047240.16481574
96Small cell lung cancer_Homo sapiens_hsa052220.16052162
97Regulation of autophagy_Homo sapiens_hsa041400.15877548
98Olfactory transduction_Homo sapiens_hsa047400.15816537
99Gap junction_Homo sapiens_hsa045400.15513150
100Serotonergic synapse_Homo sapiens_hsa047260.14962884
101Cysteine and methionine metabolism_Homo sapiens_hsa002700.14874141
102Notch signaling pathway_Homo sapiens_hsa043300.14741930
103Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.14602835
104Endometrial cancer_Homo sapiens_hsa052130.13930082
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13589229
106Circadian rhythm_Homo sapiens_hsa047100.13582620
107Dorso-ventral axis formation_Homo sapiens_hsa043200.11274259
108AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.09580550
109GnRH signaling pathway_Homo sapiens_hsa049120.09116377
110VEGF signaling pathway_Homo sapiens_hsa043700.09005137
111Taste transduction_Homo sapiens_hsa047420.08992899
112Toxoplasmosis_Homo sapiens_hsa051450.07013615
113Pancreatic secretion_Homo sapiens_hsa049720.06702681
114Fat digestion and absorption_Homo sapiens_hsa049750.06612613
115mTOR signaling pathway_Homo sapiens_hsa041500.06602082
116PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05687171
117Bile secretion_Homo sapiens_hsa049760.05638393
118Cholinergic synapse_Homo sapiens_hsa047250.05393315
119Estrogen signaling pathway_Homo sapiens_hsa049150.04511206
120Melanogenesis_Homo sapiens_hsa049160.01228329
121Rap1 signaling pathway_Homo sapiens_hsa040150.00781598

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