TNNI1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcoplasmic reticulum calcium ion transport (GO:0070296)9.19040402
2* actin-mediated cell contraction (GO:0070252)8.84103792
3myofibril assembly (GO:0030239)8.70142572
4sarcomere organization (GO:0045214)8.07976158
5heart contraction (GO:0060047)8.00172863
6heart process (GO:0003015)8.00172863
7negative regulation of cardiac muscle cell apoptotic process (GO:0010667)7.58369838
8cardiac muscle contraction (GO:0060048)7.53958278
9* cardiac muscle tissue morphogenesis (GO:0055008)7.20556863
10response to muscle activity (GO:0014850)7.05240003
11cardiac muscle cell development (GO:0055013)6.95367155
12cardiac muscle hypertrophy (GO:0003300)6.68293859
13mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.58423571
14cardiac cell development (GO:0055006)6.58188142
15* actin filament-based movement (GO:0030048)6.48710191
16* muscle tissue morphogenesis (GO:0060415)6.47230813
17negative regulation of striated muscle cell apoptotic process (GO:0010664)6.43797262
18actomyosin structure organization (GO:0031032)6.37173231
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.32884026
20striated muscle hypertrophy (GO:0014897)6.30173332
21skeletal muscle fiber development (GO:0048741)6.26630276
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.19741050
23striated muscle contraction (GO:0006941)6.13303095
24ATP synthesis coupled proton transport (GO:0015986)6.06922674
25energy coupled proton transport, down electrochemical gradient (GO:0015985)6.06922674
26* ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.98662895
27regulation of cardioblast differentiation (GO:0051890)5.81756387
28adult heart development (GO:0007512)5.77421089
29muscle cell cellular homeostasis (GO:0046716)5.74972588
30myotube cell development (GO:0014904)5.68961898
31muscle hypertrophy (GO:0014896)5.62617762
32regulation of sarcomere organization (GO:0060297)5.57483208
33negative regulation of potassium ion transmembrane transport (GO:1901380)5.45469753
34oxidative phosphorylation (GO:0006119)5.44375272
35muscle cell fate commitment (GO:0042693)5.43986095
36regulation of the force of heart contraction (GO:0002026)5.24838706
37regulation of relaxation of muscle (GO:1901077)5.20573602
38skeletal muscle tissue development (GO:0007519)5.17477414
39muscle fiber development (GO:0048747)5.15744817
40creatine metabolic process (GO:0006600)5.15602037
41striated muscle atrophy (GO:0014891)5.13975193
42skeletal muscle adaptation (GO:0043501)5.12106757
43positive regulation of myotube differentiation (GO:0010831)5.06551007
44heart trabecula formation (GO:0060347)5.00009042
45myoblast fusion (GO:0007520)4.92771489
46regulation of skeletal muscle contraction (GO:0014819)4.90450613
47striated muscle adaptation (GO:0014888)4.89760080
48regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.87245897
49negative regulation of protein localization to cell surface (GO:2000009)4.84466493
50regulation of striated muscle cell apoptotic process (GO:0010662)4.83189362
51regulation of cell communication by electrical coupling (GO:0010649)4.75721595
52tricarboxylic acid cycle (GO:0006099)4.69329732
53positive regulation of myoblast differentiation (GO:0045663)4.68464712
54ventricular cardiac muscle cell development (GO:0055015)4.67934892
55regulation of cardiac muscle cell apoptotic process (GO:0010665)4.66148320
56skeletal muscle tissue regeneration (GO:0043403)4.55772870
57muscle atrophy (GO:0014889)4.54554461
58muscle organ development (GO:0007517)4.49930974
59muscle structure development (GO:0061061)4.45648202
60outflow tract septum morphogenesis (GO:0003148)4.40243827
61syncytium formation by plasma membrane fusion (GO:0000768)4.29476409
62positive regulation of cardiac muscle tissue development (GO:0055025)4.28483365
63cardiac muscle adaptation (GO:0014887)4.26342419
64cardiac muscle hypertrophy in response to stress (GO:0014898)4.26342419
65muscle hypertrophy in response to stress (GO:0003299)4.26342419
66atrial septum morphogenesis (GO:0060413)4.19323832
67positive regulation of cardiac muscle cell proliferation (GO:0060045)4.17864143
68respiratory electron transport chain (GO:0022904)4.17293188
69regulation of actin filament-based movement (GO:1903115)4.16225297
70regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.14458278
71cardiac right ventricle morphogenesis (GO:0003215)4.11678347
72electron transport chain (GO:0022900)4.09306294
73glycogen biosynthetic process (GO:0005978)4.08591367
74glucan biosynthetic process (GO:0009250)4.08591367
75striated muscle cell development (GO:0055002)4.06823013
76cardiac chamber formation (GO:0003207)4.05200228
77glycogen catabolic process (GO:0005980)3.98230707
78cytidine deamination (GO:0009972)3.93274682
79cytidine metabolic process (GO:0046087)3.93274682
80cytidine catabolic process (GO:0006216)3.93274682
81regulation of ATPase activity (GO:0043462)3.92396181
82regulation of ATP catabolic process (GO:1903289)3.92396181
83ventricular cardiac muscle cell action potential (GO:0086005)3.90648527
84regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.90139395
85regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.89955801
86muscle adaptation (GO:0043500)3.88798987
87negative regulation of skeletal muscle tissue development (GO:0048642)3.88719645
88negative regulation of myotube differentiation (GO:0010832)3.83697413
89ATP biosynthetic process (GO:0006754)3.82061497
90positive regulation of cardiac muscle tissue growth (GO:0055023)3.81540666
91striated muscle tissue development (GO:0014706)3.79731977
92regulation of skeletal muscle cell differentiation (GO:2001014)3.79623874
93glucan catabolic process (GO:0009251)3.72491917
94NADH metabolic process (GO:0006734)3.72439788
95response to inactivity (GO:0014854)3.71963738
96response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.63804234
97syncytium formation (GO:0006949)3.62362898
98plasma membrane repair (GO:0001778)3.60477021
99regulation of calcium ion transmembrane transport (GO:1903169)3.50916727
100regulation of calcium ion transmembrane transporter activity (GO:1901019)3.50916727
101positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.50176510
102muscle cell development (GO:0055001)3.49853229
103* regulation of muscle system process (GO:0090257)3.49389853
104regulation of transforming growth factor beta2 production (GO:0032909)3.49285745
105positive regulation of ATPase activity (GO:0032781)3.49282638
106positive regulation of ATP catabolic process (GO:1903291)3.49282638
107cellular polysaccharide catabolic process (GO:0044247)3.48376300
108regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.45976394
109trabecula formation (GO:0060343)3.45456817
110* regulation of muscle contraction (GO:0006937)3.40391197
111* regulation of striated muscle contraction (GO:0006942)3.40337015
112muscle contraction (GO:0006936)3.40131702
113regulation of smooth muscle cell differentiation (GO:0051150)3.38156441
114positive regulation of cardiac muscle cell differentiation (GO:2000727)3.37895335
115myotube differentiation (GO:0014902)3.37663523
116regulation of cardiac muscle tissue development (GO:0055024)3.36334292
117positive regulation of heart growth (GO:0060421)3.36085886
118mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.34970588
119response to activity (GO:0014823)3.33935456
120regulation of myotube differentiation (GO:0010830)3.33705349
121muscle tissue development (GO:0060537)3.32441429
122regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.32404348
123regulation of cardiac muscle cell differentiation (GO:2000725)3.29961234
124uterus development (GO:0060065)3.29450636
125bundle of His cell to Purkinje myocyte communication (GO:0086069)3.29231034
126regulation of cardiac muscle cell proliferation (GO:0060043)3.28321464
127negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.27495499
128negative regulation of calcium ion transmembrane transport (GO:1903170)3.27495499
129relaxation of smooth muscle (GO:0044557)3.27001155
130cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.26766904
131neuromuscular synaptic transmission (GO:0007274)3.26691321
132regulation of skeletal muscle fiber development (GO:0048742)3.22366090
133gap junction assembly (GO:0016264)3.21889391
134negative regulation of potassium ion transport (GO:0043267)3.21358977
135negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.20580877
136membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.17070590
137pyrimidine ribonucleoside catabolic process (GO:0046133)3.15875264
138positive regulation of muscle tissue development (GO:1901863)3.14901543
139regulation of membrane repolarization (GO:0060306)3.13793060
140skeletal muscle contraction (GO:0003009)3.13514553
141polysaccharide catabolic process (GO:0000272)3.13091971
142regulation of cardiac muscle tissue growth (GO:0055021)3.13074407
143purine nucleoside triphosphate biosynthetic process (GO:0009145)3.12948355
144muscle system process (GO:0003012)3.12796551
145regulation of myoblast differentiation (GO:0045661)3.12447680
146cardiac muscle tissue development (GO:0048738)3.11268295
147negative regulation of striated muscle cell differentiation (GO:0051154)3.10485185
148purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.09302370
149glycogen metabolic process (GO:0005977)3.07047553
150carnitine shuttle (GO:0006853)3.02503575
151* muscle filament sliding (GO:0030049)10.4750995
152* actin-myosin filament sliding (GO:0033275)10.4750995
153cardiac myofibril assembly (GO:0055003)10.2694078

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EP300_21415370_ChIP-Seq_HL-1_Mouse5.52315735
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.22445793
3RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.85722898
4CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human4.41093861
5* ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.21419763
6MEF2A_21415370_ChIP-Seq_HL-1_Mouse3.93523787
7EZH2_22144423_ChIP-Seq_EOC_Human3.79218258
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.50015061
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.32513673
10TRIM28_21343339_ChIP-Seq_HEK293_Human3.31996188
11ESR1_20079471_ChIP-ChIP_T-47D_Human3.21162337
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.99451461
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.98062857
14* GATA4_21415370_ChIP-Seq_HL-1_Mouse2.97096001
15EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.93724831
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.82360518
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.82211870
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.70033415
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60639134
20TBX20_22328084_ChIP-Seq_HEART_Mouse2.59497757
21TBX20_22080862_ChIP-Seq_HEART_Mouse2.59497757
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.55361943
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.47203280
24* ISL1_27105846_Chip-Seq_CPCs_Mouse2.38093250
25CREB1_15753290_ChIP-ChIP_HEK293T_Human2.35208550
26WT1_19549856_ChIP-ChIP_CCG9911_Human2.33434938
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22692694
28NKX2-5_21415370_ChIP-Seq_HL-1_Mouse2.15677627
29MYC_18555785_ChIP-Seq_MESCs_Mouse2.04055688
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.98911120
31EST1_17652178_ChIP-ChIP_JURKAT_Human1.97185206
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92000956
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90316884
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78051284
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72645529
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.71590189
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.69985698
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.67670102
39BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.66873144
40GATA1_22025678_ChIP-Seq_K562_Human1.63720020
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58335748
42DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.53725023
43ETS1_20019798_ChIP-Seq_JURKAT_Human1.53035025
44SALL4_18804426_ChIP-ChIP_XEN_Mouse1.51216551
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.50017702
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48638335
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48020034
48TP63_19390658_ChIP-ChIP_HaCaT_Human1.47500276
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45609025
50IGF1R_20145208_ChIP-Seq_DFB_Human1.45436370
51* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.45063416
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39222183
53TBX5_21415370_ChIP-Seq_HL-1_Mouse1.37255855
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36987761
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33591581
56EZH2_27294783_Chip-Seq_ESCs_Mouse1.33553949
57* CTCF_27219007_Chip-Seq_Bcells_Human1.31061531
58SOX17_20123909_ChIP-Seq_XEN_Mouse1.30431068
59* CRX_20693478_ChIP-Seq_RETINA_Mouse1.30164701
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29963729
61CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.29025746
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.26144404
63* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.26035734
64ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.25565968
65GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.24454419
66STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.24094342
67SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23731891
68PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22612660
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.21886349
70HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20898927
71NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17162366
72PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.14941769
73PCGF2_27294783_Chip-Seq_NPCs_Mouse1.12741071
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12703027
75ELK1_19687146_ChIP-ChIP_HELA_Human1.11760519
76* EZH2_27294783_Chip-Seq_NPCs_Mouse1.11261206
77SOX9_26525672_Chip-Seq_HEART_Mouse1.10826287
78CLOCK_20551151_ChIP-Seq_293T_Human1.08579288
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.08107094
80TP63_17297297_ChIP-ChIP_HaCaT_Human1.07406846
81DCP1A_22483619_ChIP-Seq_HELA_Human1.06609466
82RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06191308
83* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05627005
84ZNF274_21170338_ChIP-Seq_K562_Hela1.05261684
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.05200935
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.04551115
87ESR2_21235772_ChIP-Seq_MCF-7_Human1.04285409
88NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04057911
89NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04057911
90NANOG_16153702_ChIP-ChIP_HESCs_Human1.03125099
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02228996
92PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02081492
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00870143
94MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00146509
95EZH2_27304074_Chip-Seq_ESCs_Mouse0.99542445
96SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99233058
97GBX2_23144817_ChIP-Seq_PC3_Human0.98823575
98MYC_27129775_Chip-Seq_CORNEA_Mouse0.97381808
99TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97049165
100* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96874874
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.96731638
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.96369328
103BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95982371
104DROSHA_22980978_ChIP-Seq_HELA_Human0.95588001
105SMAD3_21741376_ChIP-Seq_HESCs_Human0.95078356
106NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94715889
107CJUN_26792858_Chip-Seq_BT549_Human0.93865611
108* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.93709483
109ZFX_18555785_ChIP-Seq_MESCs_Mouse0.93679803
110GABP_19822575_ChIP-Seq_HepG2_Human0.93286740
111* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92520378
112VDR_22108803_ChIP-Seq_LS180_Human0.92397952
113EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91706934
114RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91706934
115RAD21_21589869_ChIP-Seq_MESCs_Mouse0.91540785
116YY1_21170310_ChIP-Seq_MESCs_Mouse0.91365122
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91061091
118CBX2_27304074_Chip-Seq_ESCs_Mouse0.90765385
119GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.90643972
120LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90515958
121FLI1_27457419_Chip-Seq_LIVER_Mouse0.89447906
122KLF5_20875108_ChIP-Seq_MESCs_Mouse0.89095657
123SMAD_19615063_ChIP-ChIP_OVARY_Human0.89016329
124ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.87854571
125SOX2_18555785_ChIP-Seq_MESCs_Mouse0.87442718
126SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87372646
127SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.86969422
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85874172
129ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83903529
130ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83813292
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82631525
132ZFP281_18757296_ChIP-ChIP_E14_Mouse0.81852303
133TP53_23651856_ChIP-Seq_MEFs_Mouse0.81753792
134ZNF263_19887448_ChIP-Seq_K562_Human0.80709790
135* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.79749366
136RARB_27405468_Chip-Seq_BRAIN_Mouse0.79715241
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78369832
138TTF2_22483619_ChIP-Seq_HELA_Human0.77281496
139TP53_20018659_ChIP-ChIP_R1E_Mouse0.76993556
140NFI_21473784_ChIP-Seq_ESCs_Mouse0.76597113
141SOX3_22085726_ChIP-Seq_NPCs_Mouse0.75879312
142XRN2_22483619_ChIP-Seq_HELA_Human0.75802750
143* SOX2_21211035_ChIP-Seq_LN229_Gbm0.75782728
144SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.74714347
145IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.74659871
146CBP_20019798_ChIP-Seq_JUKART_Human0.74659871
147HTT_18923047_ChIP-ChIP_STHdh_Human0.74279014
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.73866589
149* MYC_19829295_ChIP-Seq_ESCs_Human0.73862165
150* ZFX_18555785_Chip-Seq_ESCs_Mouse0.73734611
151JARID2_20075857_ChIP-Seq_MESCs_Mouse0.73657456
152ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.73646980
153CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73531447
154P53_22127205_ChIP-Seq_FIBROBLAST_Human0.73394985
155SOX2_16153702_ChIP-ChIP_HESCs_Human0.73056682
156STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.72979621
157GF1_26923725_Chip-Seq_HPCs_Mouse0.72738065
158HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.72503866
159* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.71682804
160* P53_22387025_ChIP-Seq_ESCs_Mouse0.71668388
161FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.71197734
162ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.69361009
163FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.68439533
164MYC_19079543_ChIP-ChIP_MESCs_Mouse0.68236199
165AR_21909140_ChIP-Seq_LNCAP_Human0.67367987
166MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.66784037
167RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66267964
168TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.65605114
169RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.65012784
170POU5F1_16153702_ChIP-ChIP_HESCs_Human0.64899283
171EOMES_21245162_ChIP-Seq_HESCs_Human0.64312598
172E2F4_17652178_ChIP-ChIP_JURKAT_Human0.63979275

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle6.40957614
2MP0000749_muscle_degeneration5.86674855
3MP0004036_abnormal_muscle_relaxation4.60416809
4MP0005330_cardiomyopathy3.78237172
5MP0002972_abnormal_cardiac_muscle3.54944950
6MP0003122_maternal_imprinting3.23103111
7MP0000751_myopathy3.05703114
8MP0004087_abnormal_muscle_fiber3.01081689
9MP0004145_abnormal_muscle_electrophysio3.01055747
10MP0008775_abnormal_heart_ventricle3.00266628
11MP0004215_abnormal_myocardial_fiber2.96793892
12MP0005451_abnormal_body_composition2.89326768
13MP0002837_dystrophic_cardiac_calcinosis2.88725980
14MP0005620_abnormal_muscle_contractility2.84435338
15MP0010630_abnormal_cardiac_muscle2.82360412
16MP0003221_abnormal_cardiomyocyte_apopto2.77851349
17MP0003950_abnormal_plasma_membrane2.76022162
18MP0004510_myositis2.72595634
19MP0003123_paternal_imprinting2.49234032
20MP0003828_pulmonary_edema2.46574972
21MP0003137_abnormal_impulse_conducting2.44134973
22MP0002127_abnormal_cardiovascular_syste2.39862063
23MP0006138_congestive_heart_failure2.39259856
24MP0002269_muscular_atrophy2.32640214
25MP0002106_abnormal_muscle_physiology2.32017533
26MP0005385_cardiovascular_system_phenoty2.28679065
27MP0001544_abnormal_cardiovascular_syste2.28679065
28MP0003121_genomic_imprinting2.19436526
29MP0003567_abnormal_fetal_cardiomyocyte2.17525395
30MP0004085_abnormal_heartbeat2.11279694
31MP0002108_abnormal_muscle_morphology2.11023738
32MP0004130_abnormal_muscle_cell2.09569383
33MP0004270_analgesia1.95607653
34MP0000747_muscle_weakness1.84665946
35MP0005369_muscle_phenotype1.84263199
36MP0004233_abnormal_muscle_weight1.77861552
37MP0003806_abnormal_nucleotide_metabolis1.76662221
38MP0000759_abnormal_skeletal_muscle1.65552483
39MP0003646_muscle_fatigue1.57451262
40MP0006036_abnormal_mitochondrial_physio1.53489130
41MP0000750_abnormal_muscle_regeneration1.52642443
42MP0004484_altered_response_of1.43026333
43MP0004272_abnormal_basement_membrane1.33911741
44MP0000013_abnormal_adipose_tissue1.30392483
45MP0000266_abnormal_heart_morphology1.27569241
46MP0003941_abnormal_skin_development1.14509072
47MP0002088_abnormal_embryonic_growth/wei1.07169625
48MP0002332_abnormal_exercise_endurance1.07108856
49MP0003878_abnormal_ear_physiology1.05890847
50MP0005377_hearing/vestibular/ear_phenot1.05890847
51MP0009384_cardiac_valve_regurgitation1.05731181
52MP0003984_embryonic_growth_retardation1.05012965
53MP0003385_abnormal_body_wall1.02508408
54MP0000537_abnormal_urethra_morphology1.02183470
55MP0001661_extended_life_span0.97296583
56MP0001730_embryonic_growth_arrest0.96735287
57MP0009697_abnormal_copulation0.92075853
58MP0000762_abnormal_tongue_morphology0.89180446
59MP0006035_abnormal_mitochondrial_morpho0.88423452
60MP0003566_abnormal_cell_adhesion0.88212765
61MP0002822_catalepsy0.87048866
62MP0002971_abnormal_brown_adipose0.85661513
63MP0010030_abnormal_orbit_morphology0.84375260
64MP0003115_abnormal_respiratory_system0.81846211
65MP0001299_abnormal_eye_distance/0.81708996
66MP0002925_abnormal_cardiovascular_devel0.81656181
67MP0003279_aneurysm0.80688818
68MP0005380_embryogenesis_phenotype0.78493857
69MP0001672_abnormal_embryogenesis/_devel0.78493857
70MP0005367_renal/urinary_system_phenotyp0.76343026
71MP0000516_abnormal_urinary_system0.76343026
72MP0002128_abnormal_blood_circulation0.72615143
73MP0001784_abnormal_fluid_regulation0.72314422
74MP0003942_abnormal_urinary_system0.70915103
75MP0000733_abnormal_muscle_development0.70603059
76MP0000767_abnormal_smooth_muscle0.69277515
77MP0000372_irregular_coat_pigmentation0.66943561
78MP0002638_abnormal_pupillary_reflex0.66388314
79MP0000230_abnormal_systemic_arterial0.66201694
80MP0003315_abnormal_perineum_morphology0.65832529
81MP0005266_abnormal_metabolism0.65805892
82MP0008877_abnormal_DNA_methylation0.64956102
83MP0001697_abnormal_embryo_size0.63434640
84MP0005248_abnormal_Harderian_gland0.62311687
85MP0002086_abnormal_extraembryonic_tissu0.62109489
86MP0001485_abnormal_pinna_reflex0.61562086
87MP0002282_abnormal_trachea_morphology0.59378014
88MP0004134_abnormal_chest_morphology0.59192934
89MP0009780_abnormal_chondrocyte_physiolo0.58950946
90MP0004197_abnormal_fetal_growth/weight/0.58778698
91MP0002249_abnormal_larynx_morphology0.58380920
92MP0003119_abnormal_digestive_system0.58012494
93MP0003705_abnormal_hypodermis_morpholog0.57774496
94MP0002938_white_spotting0.56816534
95MP0000003_abnormal_adipose_tissue0.56806207
96MP0003045_fibrosis0.56549886
97MP0009672_abnormal_birth_weight0.56359686
98MP0005171_absent_coat_pigmentation0.56108402
99MP0009053_abnormal_anal_canal0.54572434
100MP0001614_abnormal_blood_vessel0.54435450
101MP0002933_joint_inflammation0.52105942
102MP0002234_abnormal_pharynx_morphology0.49980856
103MP0008007_abnormal_cellular_replicative0.48051559
104MP0005375_adipose_tissue_phenotype0.47892016
105MP0008932_abnormal_embryonic_tissue0.47334019
106MP0002734_abnormal_mechanical_nocicepti0.45338948
107MP0004133_heterotaxia0.44652795
108MP0003937_abnormal_limbs/digits/tail_de0.44422234
109MP0003948_abnormal_gas_homeostasis0.44415016
110MP0009250_abnormal_appendicular_skeleto0.43926274
111MP0001542_abnormal_bone_strength0.43698704
112MP0001175_abnormal_lung_morphology0.43621453
113MP0002080_prenatal_lethality0.43547122
114MP0004185_abnormal_adipocyte_glucose0.42758682
115MP0002114_abnormal_axial_skeleton0.42263254
116MP0004147_increased_porphyrin_level0.41763537
117MP0005408_hypopigmentation0.41226951
118MP0003172_abnormal_lysosome_physiology0.41158252
119MP0005165_increased_susceptibility_to0.40906894
120MP0005670_abnormal_white_adipose0.40864584
121MP0005595_abnormal_vascular_smooth0.38711741
122MP0003077_abnormal_cell_cycle0.38254656
123MP0005666_abnormal_adipose_tissue0.38206588
124MP0004043_abnormal_pH_regulation0.37856361
125MP0001346_abnormal_lacrimal_gland0.36255185
126MP0004142_abnormal_muscle_tone0.35649273
127MP0003879_abnormal_hair_cell0.35579166
128MP0008438_abnormal_cutaneous_collagen0.34518008
129MP0004858_abnormal_nervous_system0.33165256
130MP0001958_emphysema0.32788710
131MP0003011_delayed_dark_adaptation0.30660570
132MP0002896_abnormal_bone_mineralization0.30309746
133MP0001943_abnormal_respiration0.28014851
134MP0005452_abnormal_adipose_tissue0.25002138
135MP0002078_abnormal_glucose_homeostasis0.24108348
136MP0005584_abnormal_enzyme/coenzyme_acti0.23493787
137MP0005376_homeostasis/metabolism_phenot0.23334575
138MP0005187_abnormal_penis_morphology0.22258375
139MP0008569_lethality_at_weaning0.21932971
140MP0003959_abnormal_lean_body0.19986211
141MP0005319_abnormal_enzyme/_coenzyme0.19368652
142MP0005166_decreased_susceptibility_to0.17983234

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)7.33873208
2Sudden death (HP:0001699)6.53167648
3Calf muscle hypertrophy (HP:0008981)6.49450189
4Exercise-induced myalgia (HP:0003738)5.94072622
5Muscle hypertrophy of the lower extremities (HP:0008968)5.88210589
6Subaortic stenosis (HP:0001682)5.78964967
7Abnormality of the left ventricular outflow tract (HP:0011103)5.78964967
8Lipoatrophy (HP:0100578)5.03348355
9Centrally nucleated skeletal muscle fibers (HP:0003687)5.02435014
10Ventricular tachycardia (HP:0004756)4.98212329
11Type 1 muscle fiber predominance (HP:0003803)4.97756150
12Abnormality of the calf musculature (HP:0001430)4.94860288
13Myopathic facies (HP:0002058)4.80560595
14Atrial fibrillation (HP:0005110)4.78002360
15Ulnar deviation of the wrist (HP:0003049)4.70002476
16Primary atrial arrhythmia (HP:0001692)4.40424348
17EMG: myopathic abnormalities (HP:0003458)4.33217255
18Nemaline bodies (HP:0003798)4.30017989
19Supraventricular tachycardia (HP:0004755)4.29307984
20Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.19794727
21Hyporeflexia of lower limbs (HP:0002600)4.18730604
22Supraventricular arrhythmia (HP:0005115)4.18573655
23Calcaneovalgus deformity (HP:0001848)4.18107328
24Malignant hyperthermia (HP:0002047)4.14632585
25Muscle fiber inclusion bodies (HP:0100299)4.11409543
26Type 2 muscle fiber atrophy (HP:0003554)4.09661710
27Myoglobinuria (HP:0002913)3.96048127
28Ventricular arrhythmia (HP:0004308)3.91334908
29Fatigable weakness (HP:0003473)3.90525751
30Abnormality of the neuromuscular junction (HP:0003398)3.90525751
31Dilated cardiomyopathy (HP:0001644)3.87605203
32Congenital malformation of the right heart (HP:0011723)3.83390283
33Double outlet right ventricle (HP:0001719)3.83390283
34Weak cry (HP:0001612)3.72694594
35Deformed tarsal bones (HP:0008119)3.72125954
36Muscle fiber atrophy (HP:0100295)3.71703307
37Neck muscle weakness (HP:0000467)3.69681644
38Absent phalangeal crease (HP:0006109)3.69438954
39Increased serum pyruvate (HP:0003542)3.67270353
40Abnormality of glycolysis (HP:0004366)3.67270353
41Ragged-red muscle fibers (HP:0003200)3.64593217
42Abnormality of skeletal muscle fiber size (HP:0012084)3.58540042
43Abnormality of placental membranes (HP:0011409)3.57174851
44Amniotic constriction ring (HP:0009775)3.57174851
45Prolonged QT interval (HP:0001657)3.56013904
46Gowers sign (HP:0003391)3.55670853
47Rhabdomyolysis (HP:0003201)3.45250028
48Hypoplastic heart (HP:0001961)3.34279747
49Bundle branch block (HP:0011710)3.26773858
50Difficulty running (HP:0009046)3.26178632
51Acute necrotizing encephalopathy (HP:0006965)3.25943153
52Patent foramen ovale (HP:0001655)3.22841162
53Palpitations (HP:0001962)3.21411329
54Right ventricular cardiomyopathy (HP:0011663)3.18981132
55Asymmetric septal hypertrophy (HP:0001670)3.15894462
56Syncope (HP:0001279)3.09022714
57Abnormal mitochondria in muscle tissue (HP:0008316)3.08873756
58Abnormal finger flexion creases (HP:0006143)3.05699242
59Increased variability in muscle fiber diameter (HP:0003557)3.03842246
60Generalized muscle weakness (HP:0003324)3.03576153
61Increased connective tissue (HP:0009025)2.99301308
62Pheochromocytoma (HP:0002666)2.97226126
63Hypoplastic left heart (HP:0004383)2.97057753
64Exercise intolerance (HP:0003546)2.96847321
65Neoplasm of the adrenal gland (HP:0100631)2.95650973
66Bulbar palsy (HP:0001283)2.85227233
67Conjunctival hamartoma (HP:0100780)2.85126605
68Rimmed vacuoles (HP:0003805)2.81940364
69Aplasia of the musculature (HP:0100854)2.80145193
70Left ventricular hypertrophy (HP:0001712)2.79303298
71Distal lower limb muscle weakness (HP:0009053)2.75402916
72Diaphragmatic weakness (HP:0009113)2.74573414
73Muscle fiber splitting (HP:0003555)2.72544109
74Frequent falls (HP:0002359)2.71665658
75Neuroendocrine neoplasm (HP:0100634)2.71271431
76Hip contracture (HP:0003273)2.69228388
77Steppage gait (HP:0003376)2.68407610
78Mitochondrial inheritance (HP:0001427)2.65413947
79Increased CSF lactate (HP:0002490)2.63837731
80Abnormal EKG (HP:0003115)2.60442329
81Limb-girdle muscle atrophy (HP:0003797)2.58601821
82Progressive macrocephaly (HP:0004481)2.55828272
83Acute encephalopathy (HP:0006846)2.55203692
84Palmoplantar keratoderma (HP:0000982)2.53300193
85EMG: neuropathic changes (HP:0003445)2.52207438
86Easy fatigability (HP:0003388)2.48890829
87Hepatic necrosis (HP:0002605)2.48743094
88Abnormality of the calcaneus (HP:0008364)2.43767911
89Abnormality of the foot musculature (HP:0001436)2.40781416
90Abnormal ventriculo-arterial connection (HP:0011563)2.40726570
91Transposition of the great arteries (HP:0001669)2.40726570
92Abnormal connection of the cardiac segments (HP:0011545)2.40726570
93Ventricular fibrillation (HP:0001663)2.38748952
94Mildly elevated creatine phosphokinase (HP:0008180)2.37031068
95Distal lower limb amyotrophy (HP:0008944)2.32035914
96Respiratory insufficiency due to muscle weakness (HP:0002747)2.31831310
97Hepatoblastoma (HP:0002884)2.30112694
98Muscle stiffness (HP:0003552)2.22978947
99Periauricular skin pits (HP:0100277)2.22944455
100Preauricular pit (HP:0004467)2.22944455
101Hepatocellular necrosis (HP:0001404)2.21070106
102Abnormal gallbladder physiology (HP:0012438)2.21009952
103Cholecystitis (HP:0001082)2.21009952
104Nonprogressive disorder (HP:0003680)2.20186602
105Thin ribs (HP:0000883)2.19935157
106Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.18044775
107Pterygium (HP:0001059)2.15139050
108Slender build (HP:0001533)2.08903680
109Waddling gait (HP:0002515)2.07196041
110Heart block (HP:0012722)2.06976714
111Areflexia of lower limbs (HP:0002522)2.04915412
112Distal arthrogryposis (HP:0005684)2.03798352
113Difficulty climbing stairs (HP:0003551)2.03786890
114Diastasis recti (HP:0001540)2.02318809
115Myotonia (HP:0002486)1.97233030
116Abnormal atrioventricular conduction (HP:0005150)1.96600194
117Abnormal pancreas size (HP:0012094)1.96066869
118Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95311725
119Glycosuria (HP:0003076)1.95276952
120Abnormality of urine glucose concentration (HP:0011016)1.95276952
121Progressive muscle weakness (HP:0003323)1.94130041
122Spinal rigidity (HP:0003306)1.92697905
123Long clavicles (HP:0000890)1.91157575
124Round ear (HP:0100830)1.90533877
125Muscular dystrophy (HP:0003560)1.90362154
126Limited hip movement (HP:0008800)1.89543510
127Foot dorsiflexor weakness (HP:0009027)1.89218486
128Cerebral edema (HP:0002181)1.87548026
129Abnormality of the shoulder girdle musculature (HP:0001435)1.87257588
130Increased hepatocellular lipid droplets (HP:0006565)1.87030201
131Akinesia (HP:0002304)1.84777547
132Proximal amyotrophy (HP:0007126)1.80521320
133Lipid accumulation in hepatocytes (HP:0006561)1.79958247
134Increased serum lactate (HP:0002151)1.79462313
135Fetal akinesia sequence (HP:0001989)1.78593211
136Abnormality of the fetal cardiovascular system (HP:0010948)1.78304837
137Abnormal umbilical cord blood vessels (HP:0011403)1.78304837
138Single umbilical artery (HP:0001195)1.78304837
139Metatarsus adductus (HP:0001840)1.77056552
140Respiratory failure (HP:0002878)1.74501408
141Lower limb amyotrophy (HP:0007210)1.74309837
142Limb-girdle muscle weakness (HP:0003325)1.73057334
143Subacute progressive viral hepatitis (HP:0006572)1.72624517
144Lactic acidosis (HP:0003128)1.72360443
145Popliteal pterygium (HP:0009756)1.71880969
146Pancreatic islet-cell hyperplasia (HP:0004510)1.70792427
147Scapular winging (HP:0003691)1.70390162
148Facial diplegia (HP:0001349)1.66689992
149Abnormality of the musculature of the pelvis (HP:0001469)1.64015311
150Abnormality of the hip-girdle musculature (HP:0001445)1.64015311
151Hyperkalemia (HP:0002153)1.58752248
152Cystic hygroma (HP:0000476)1.55921398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK4.96807222
2STK243.94867297
3ZAK3.69394326
4STK38L2.89381544
5LIMK12.76689567
6PIK3CA2.55649607
7PKN22.29324433
8TESK12.02234703
9CDC42BPA2.01965708
10OBSCN10.8621364
11BRSK21.76956724
12CCNB11.74388035
13TRPM71.69394889
14PINK11.64635428
15ILK1.62808116
16MUSK1.55678022
17DMPK1.50971340
18PRKD31.39094338
19NEK11.37540505
20MAPKAPK31.35610341
21DAPK31.31178687
22BRSK11.17289092
23MARK11.12693136
24PLK40.99821590
25ROCK10.93051489
26STK390.92583992
27NUAK10.92220743
28PIK3CG0.90749531
29FLT30.90618542
30STK30.89798613
31MARK30.88061502
32MAP3K100.86249174
33MAP2K40.83626127
34BCR0.83221156
35PHKG10.82751721
36PHKG20.82751721
37BCKDK0.80907112
38PTK2B0.78381772
39NEK90.75936997
40PDK30.74453614
41PDK40.74453614
42PAK20.74152234
43MAPK70.71633130
44TTN0.70699978
45STK40.66653928
46DYRK1B0.64298510
47MAP2K10.63241217
48MAP3K30.61541509
49WNK40.60499228
50PKN10.59181232
51EEF2K0.58478154
52MAP2K30.58018391
53CAMK40.55446830
54FGFR10.55024962
55ERBB30.54959404
56UHMK10.52908166
57PAK30.52179443
58MAP3K130.51170564
59MAP2K60.50331187
60CAMK2D0.50197828
61CAMK10.50131220
62MAPK40.49404401
63MAP3K120.48435591
64PLK20.47717226
65ROCK20.47213697
66AKT30.46978243
67PLK30.46692676
68CAMK2B0.45562830
69ICK0.45493741
70MAPK110.44730382
71TIE10.44038523
72PRPF4B0.43459528
73MAPK120.42032858
74MAP3K50.41224881
75ARAF0.40933126
76PRKG10.40518157
77SRPK10.40320638
78PRKACB0.39285154
79AKT20.38296972
80DDR20.37471295
81PAK10.36617057
82TRIB30.36467250
83NME10.34227751
84MAP3K70.33790451
85KSR20.33473129
86AURKB0.32662733
87MINK10.32244120
88CLK10.32103149
89MKNK10.31909473
90CAMK2A0.31681349
91PRKD10.31034376
92EPHB20.30774262
93CAMK2G0.30216555
94MELK0.29670258
95RAF10.29471582
96WNK10.29336844
97EGFR0.27934558
98VRK10.27708711
99CDK80.26991455
100RPS6KC10.26667684
101RPS6KL10.26667684
102GRK70.25308701
103MAP3K110.25282872
104DYRK20.25141363
105PRKAA10.25095576
106MOS0.24903981
107MARK20.23761283
108SGK30.23377643
109RPS6KA30.22617911
110KSR10.21721107
111PDK20.21444732
112MAPK100.21137508
113PRKAA20.20937060
114MKNK20.19927476
115PRKACA0.19855573
116RIPK10.19823135
117MAPK130.19750919
118NEK60.18887967
119TTK0.18638231
120RPS6KA60.18438423
121CDK180.17175254
122EIF2AK20.16663467
123LATS20.16602979
124PRKCQ0.16562587
125CDK40.16545140
126CDK140.16088229
127TBK10.13791824
128RPS6KB10.12738870
129SGK20.11871617
130SIK10.11100710
131SGK10.09693274
132PRKACG0.09187473
133MTOR0.09043587
134RPS6KB20.09032454
135CDK190.08280535
136LATS10.08249268
137DAPK20.08240135
138EPHB10.07445737
139RPS6KA10.06717073
140STK160.06249911
141STK110.06223161
142PDK10.04646752
143MAP3K90.04132570
144TGFBR20.03062036
145PRKCA0.02841508
146PDPK10.02733676
147CSNK1D0.02076528

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042606.11076912
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.01898715
3Parkinsons disease_Homo sapiens_hsa050124.30380082
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.14504407
5Oxidative phosphorylation_Homo sapiens_hsa001904.10245190
6Dilated cardiomyopathy_Homo sapiens_hsa054143.78460815
7Huntingtons disease_Homo sapiens_hsa050163.00511680
8Alzheimers disease_Homo sapiens_hsa050102.88676423
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.84845868
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.62483698
11Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.52346256
12Carbon metabolism_Homo sapiens_hsa012002.43058118
13Circadian rhythm_Homo sapiens_hsa047102.37514211
14Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.33099416
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.10819147
16Biosynthesis of amino acids_Homo sapiens_hsa012302.02507470
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.90040800
18Proteasome_Homo sapiens_hsa030501.83757703
19Tight junction_Homo sapiens_hsa045301.54388354
20Galactose metabolism_Homo sapiens_hsa000521.49608760
21Pyruvate metabolism_Homo sapiens_hsa006201.41768917
22Fructose and mannose metabolism_Homo sapiens_hsa000511.36605434
23Propanoate metabolism_Homo sapiens_hsa006401.36156101
24Arginine biosynthesis_Homo sapiens_hsa002201.33267640
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32077623
26Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28240549
27HIF-1 signaling pathway_Homo sapiens_hsa040661.24947153
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23181028
29Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.22574912
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.15244228
31Mismatch repair_Homo sapiens_hsa034301.09112364
32cGMP-PKG signaling pathway_Homo sapiens_hsa040220.99921024
33Adipocytokine signaling pathway_Homo sapiens_hsa049200.93134797
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91766473
35Glucagon signaling pathway_Homo sapiens_hsa049220.90729750
36Fatty acid elongation_Homo sapiens_hsa000620.86860037
37RNA degradation_Homo sapiens_hsa030180.86230480
38Hippo signaling pathway_Homo sapiens_hsa043900.85793956
39Renin secretion_Homo sapiens_hsa049240.85628243
40Starch and sucrose metabolism_Homo sapiens_hsa005000.82937928
41Gastric acid secretion_Homo sapiens_hsa049710.76033874
42Focal adhesion_Homo sapiens_hsa045100.75603903
43RNA polymerase_Homo sapiens_hsa030200.72634097
44Vascular smooth muscle contraction_Homo sapiens_hsa042700.70371403
45Viral myocarditis_Homo sapiens_hsa054160.67097505
46Homologous recombination_Homo sapiens_hsa034400.66741870
47Basal cell carcinoma_Homo sapiens_hsa052170.65082886
48Cell cycle_Homo sapiens_hsa041100.64163563
49Fatty acid metabolism_Homo sapiens_hsa012120.63962685
50Phenylalanine metabolism_Homo sapiens_hsa003600.63341866
51Pentose phosphate pathway_Homo sapiens_hsa000300.61868320
52TGF-beta signaling pathway_Homo sapiens_hsa043500.59270163
53DNA replication_Homo sapiens_hsa030300.58307515
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57995028
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56970408
56Nitrogen metabolism_Homo sapiens_hsa009100.56804216
57Fatty acid degradation_Homo sapiens_hsa000710.56708934
58Adherens junction_Homo sapiens_hsa045200.56448064
59Tyrosine metabolism_Homo sapiens_hsa003500.55695751
60Base excision repair_Homo sapiens_hsa034100.55472019
61Oocyte meiosis_Homo sapiens_hsa041140.53829072
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.53153005
63FoxO signaling pathway_Homo sapiens_hsa040680.52849984
64Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52008259
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.51928490
66Insulin secretion_Homo sapiens_hsa049110.51437925
67GnRH signaling pathway_Homo sapiens_hsa049120.51166349
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51077203
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.50308046
70Hedgehog signaling pathway_Homo sapiens_hsa043400.49589527
71Oxytocin signaling pathway_Homo sapiens_hsa049210.49368518
72Butanoate metabolism_Homo sapiens_hsa006500.49296202
73Protein export_Homo sapiens_hsa030600.49183799
74Metabolic pathways_Homo sapiens_hsa011000.48247135
75Salivary secretion_Homo sapiens_hsa049700.47910102
76Ribosome_Homo sapiens_hsa030100.45109178
77Sulfur metabolism_Homo sapiens_hsa009200.43937784
78Long-term potentiation_Homo sapiens_hsa047200.43702416
79RNA transport_Homo sapiens_hsa030130.43449030
80Nucleotide excision repair_Homo sapiens_hsa034200.43359769
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41381427
82Purine metabolism_Homo sapiens_hsa002300.41207054
83PPAR signaling pathway_Homo sapiens_hsa033200.41136815
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.38804283
85MAPK signaling pathway_Homo sapiens_hsa040100.38419594
86Amoebiasis_Homo sapiens_hsa051460.38083169
87mRNA surveillance pathway_Homo sapiens_hsa030150.38042045
88Glutathione metabolism_Homo sapiens_hsa004800.36609452
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35730957
90Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35072707
91Pyrimidine metabolism_Homo sapiens_hsa002400.34306149
92Calcium signaling pathway_Homo sapiens_hsa040200.34296091
93Lysine degradation_Homo sapiens_hsa003100.33903466
94Proteoglycans in cancer_Homo sapiens_hsa052050.33779210
95beta-Alanine metabolism_Homo sapiens_hsa004100.33157792
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33000708
97Insulin signaling pathway_Homo sapiens_hsa049100.32182387
98Wnt signaling pathway_Homo sapiens_hsa043100.31739804
99Tryptophan metabolism_Homo sapiens_hsa003800.30632423
100Basal transcription factors_Homo sapiens_hsa030220.30027007
101cAMP signaling pathway_Homo sapiens_hsa040240.30011041
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27797001
103Cholinergic synapse_Homo sapiens_hsa047250.26420476
104Protein digestion and absorption_Homo sapiens_hsa049740.25040518
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22847031
106Insulin resistance_Homo sapiens_hsa049310.22340251
107Pancreatic secretion_Homo sapiens_hsa049720.21847240
108Spliceosome_Homo sapiens_hsa030400.21401696
109Gap junction_Homo sapiens_hsa045400.20700717
110Melanogenesis_Homo sapiens_hsa049160.20492872
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.18427321
112Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.18292117
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.17845149
114HTLV-I infection_Homo sapiens_hsa051660.17139014
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.16800727
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.16607809
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.16154744
118Non-homologous end-joining_Homo sapiens_hsa034500.15856423
119Epstein-Barr virus infection_Homo sapiens_hsa051690.15590222
120One carbon pool by folate_Homo sapiens_hsa006700.13962177
121Platelet activation_Homo sapiens_hsa046110.12674948
122Long-term depression_Homo sapiens_hsa047300.11191225
123ECM-receptor interaction_Homo sapiens_hsa045120.10884112
124Amphetamine addiction_Homo sapiens_hsa050310.10716440
125Ovarian steroidogenesis_Homo sapiens_hsa049130.10456312
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.09984329
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.09656024
128Regulation of autophagy_Homo sapiens_hsa041400.09603800
129Arachidonic acid metabolism_Homo sapiens_hsa005900.09108277
130Sulfur relay system_Homo sapiens_hsa041220.08477910
131Arginine and proline metabolism_Homo sapiens_hsa003300.08321490
132Glioma_Homo sapiens_hsa052140.08163204
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.07728624
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07515893
135AMPK signaling pathway_Homo sapiens_hsa041520.06156991
136Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.06102086
137Fanconi anemia pathway_Homo sapiens_hsa034600.04283640
138Circadian entrainment_Homo sapiens_hsa047130.02241825
139Peroxisome_Homo sapiens_hsa041460.01104141
140Endometrial cancer_Homo sapiens_hsa052130.00039230
141Pathways in cancer_Homo sapiens_hsa05200-0.0051397

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