TNKS2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.84334317
2nuclear pore organization (GO:0006999)5.59232928
3pre-miRNA processing (GO:0031054)4.79889052
4mitotic sister chromatid cohesion (GO:0007064)4.21741452
5pore complex assembly (GO:0046931)4.13934320
6regulation of RNA export from nucleus (GO:0046831)3.93934940
7negative regulation of histone methylation (GO:0031061)3.85970266
8regulation of gene silencing by RNA (GO:0060966)3.82675673
9regulation of posttranscriptional gene silencing (GO:0060147)3.82675673
10regulation of gene silencing by miRNA (GO:0060964)3.82675673
11paraxial mesoderm development (GO:0048339)3.74245972
12regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.63414616
13cytoplasmic mRNA processing body assembly (GO:0033962)3.58780500
14regulation of NFAT protein import into nucleus (GO:0051532)3.58114193
15embryonic process involved in female pregnancy (GO:0060136)3.56443444
16hippo signaling (GO:0035329)3.51949280
17polarized epithelial cell differentiation (GO:0030859)3.51382427
18regulation of sister chromatid cohesion (GO:0007063)3.50032627
19positive regulation of SMAD protein import into nucleus (GO:0060391)3.49829855
20regulation of histone H3-K9 methylation (GO:0051570)3.45724315
21DNA unwinding involved in DNA replication (GO:0006268)3.43002090
22histone H2A monoubiquitination (GO:0035518)3.26689721
23phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.25195623
24regulation of nucleobase-containing compound transport (GO:0032239)3.17649662
25NLS-bearing protein import into nucleus (GO:0006607)3.12994819
26establishment of apical/basal cell polarity (GO:0035089)3.12618248
27dorsal/ventral axis specification (GO:0009950)3.11057372
28protein localization to kinetochore (GO:0034501)3.09983781
29regulation of SMAD protein import into nucleus (GO:0060390)3.05873369
30heterochromatin organization (GO:0070828)3.04675238
31negative regulation of DNA repair (GO:0045738)3.04351622
32mitotic nuclear envelope disassembly (GO:0007077)3.00579162
33membrane disassembly (GO:0030397)2.96578941
34nuclear envelope disassembly (GO:0051081)2.96578941
35chromatin assembly (GO:0031497)2.95675708
36regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.93515921
37gastrulation with mouth forming second (GO:0001702)2.91033688
38regulation of mitotic spindle organization (GO:0060236)2.91030854
39regulation of centriole replication (GO:0046599)2.89748761
40DNA replication-dependent nucleosome assembly (GO:0006335)2.85413722
41DNA replication-dependent nucleosome organization (GO:0034723)2.85413722
42regulation of translational fidelity (GO:0006450)2.80359817
43DNA duplex unwinding (GO:0032508)2.79830609
44DNA geometric change (GO:0032392)2.78003601
45protein localization to endosome (GO:0036010)2.77973726
46mitotic chromosome condensation (GO:0007076)2.77674477
47peptidyl-lysine dimethylation (GO:0018027)2.77370975
48regulation of spindle organization (GO:0090224)2.76457320
49glucocorticoid receptor signaling pathway (GO:0042921)2.76345614
50positive regulation of macroautophagy (GO:0016239)2.75854289
51regulation of DNA endoreduplication (GO:0032875)2.75753098
52mRNA stabilization (GO:0048255)2.73316273
53RNA stabilization (GO:0043489)2.73316273
54positive regulation of chromosome segregation (GO:0051984)2.73247233
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.72735092
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.72735092
57positive regulation of mitotic sister chromatid separation (GO:1901970)2.72735092
58embryonic foregut morphogenesis (GO:0048617)2.71685352
59regulation of helicase activity (GO:0051095)2.71615052
60histone H3-K9 demethylation (GO:0033169)2.71049650
61sister chromatid segregation (GO:0000819)2.70568505
62COPII vesicle coating (GO:0048208)2.70102844
63establishment of monopolar cell polarity (GO:0061162)2.69436862
64establishment or maintenance of monopolar cell polarity (GO:0061339)2.69436862
65spindle assembly involved in mitosis (GO:0090307)2.68900364
66regulation of hippo signaling (GO:0035330)2.66915263
67anterior/posterior axis specification, embryo (GO:0008595)2.62767586
68dosage compensation (GO:0007549)2.62127676
69negative regulation of fibroblast apoptotic process (GO:2000270)2.60513522
70response to laminar fluid shear stress (GO:0034616)2.60506172
71microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.59905022
72ectodermal placode formation (GO:0060788)2.58971420
73regulation of transforming growth factor beta2 production (GO:0032909)2.57539544
74protein demethylation (GO:0006482)2.57448929
75protein dealkylation (GO:0008214)2.57448929
76regulation of histone H3-K27 methylation (GO:0061085)2.53873211
77insulin-like growth factor receptor signaling pathway (GO:0048009)2.51966056
78nuclear envelope organization (GO:0006998)2.50967535
79negative regulation of histone modification (GO:0031057)2.49094376
80sarcoplasmic reticulum calcium ion transport (GO:0070296)2.45409367
81trophectodermal cell differentiation (GO:0001829)2.45051624
82histone lysine demethylation (GO:0070076)2.44828412
83skin morphogenesis (GO:0043589)2.43446716
84embryonic camera-type eye morphogenesis (GO:0048596)2.41668268
85cytoskeletal anchoring at plasma membrane (GO:0007016)2.40280309
86peptidyl-threonine modification (GO:0018210)2.40056464
87spliceosomal tri-snRNP complex assembly (GO:0000244)2.39724453
88regulation of translational termination (GO:0006449)2.37753641
89lung-associated mesenchyme development (GO:0060484)2.37304349
90regulation of centrosome duplication (GO:0010824)2.36926702
91planar cell polarity pathway involved in neural tube closure (GO:0090179)2.36101805
92mitotic cytokinesis (GO:0000281)2.36012952
93negative regulation of chromatin modification (GO:1903309)2.35546207
94regulation of gene silencing (GO:0060968)2.35509848
95adherens junction assembly (GO:0034333)2.35429135
96histone demethylation (GO:0016577)2.35277779
97regulation of mRNA stability (GO:0043488)2.34916670
98mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.34335134
99protein localization to chromosome, centromeric region (GO:0071459)2.33533694
100early endosome to late endosome transport (GO:0045022)2.33394888
101mRNA transcription (GO:0009299)2.33286167
102peptidyl-threonine phosphorylation (GO:0018107)2.32928249
103regulation of centrosome cycle (GO:0046605)2.32677892
104chondrocyte development (GO:0002063)2.31489025
105epithelial cell differentiation involved in prostate gland development (GO:0060742)2.31386614
106actin filament-based movement (GO:0030048)2.30633511
107morphogenesis of an epithelial sheet (GO:0002011)2.30068643
108gene silencing by RNA (GO:0031047)2.30014613
109regulation of chromosome segregation (GO:0051983)2.29985940
110hypotonic response (GO:0006971)2.29384533
111regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.29145955
112establishment of nucleus localization (GO:0040023)2.28851244
113regulation of catenin import into nucleus (GO:0035412)2.28550576
114negative regulation of cell fate specification (GO:0009996)2.28343116
115mitotic spindle checkpoint (GO:0071174)2.27250542
116vesicle coating (GO:0006901)2.26830364
117spindle checkpoint (GO:0031577)2.26582448
118nucleus localization (GO:0051647)2.26261773
119establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.25860753
120positive regulation of cellular response to insulin stimulus (GO:1900078)2.25603784
121cell-substrate junction assembly (GO:0007044)2.25432570
122focal adhesion assembly (GO:0048041)2.25095265
123cell-substrate adherens junction assembly (GO:0007045)2.25095265
124genitalia morphogenesis (GO:0035112)2.23853051
125Rap protein signal transduction (GO:0032486)2.23480553
126mRNA transcription from RNA polymerase II promoter (GO:0042789)2.22896903
127definitive hemopoiesis (GO:0060216)2.22530189
128monoubiquitinated protein deubiquitination (GO:0035520)2.21938114
129positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.21733372
130regulation of protein polyubiquitination (GO:1902914)2.21340177
131histone H3-K36 demethylation (GO:0070544)2.21088422
132corticosteroid receptor signaling pathway (GO:0031958)2.21017913
133glial cell proliferation (GO:0014009)2.20831024
134regulation of mitotic metaphase/anaphase transition (GO:0030071)2.20191619
135regulation of skeletal muscle cell differentiation (GO:2001014)2.19121372
136positive regulation of insulin receptor signaling pathway (GO:0046628)2.19023604
137COPI coating of Golgi vesicle (GO:0048205)2.18258279
138Golgi transport vesicle coating (GO:0048200)2.18258279
139negative regulation of NF-kappaB import into nucleus (GO:0042347)2.16719463
140negative regulation of erythrocyte differentiation (GO:0045647)2.16511356
141regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.14871900
142Golgi organization (GO:0007030)2.14844174
143growth hormone receptor signaling pathway (GO:0060396)2.12692388
144platelet-derived growth factor receptor signaling pathway (GO:0048008)2.12316515
145plasma membrane repair (GO:0001778)2.12213320
146epithelial cell-cell adhesion (GO:0090136)2.11529276
147cellular response to fluid shear stress (GO:0071498)2.08738280
148SMAD protein complex assembly (GO:0007183)2.07945182
149cell adhesion mediated by integrin (GO:0033627)2.07323753
150interkinetic nuclear migration (GO:0022027)2.07303341
151coronary vasculature morphogenesis (GO:0060977)2.07067847
152muscle filament sliding (GO:0030049)2.06294970
153actin-myosin filament sliding (GO:0033275)2.06294970
154embryonic eye morphogenesis (GO:0048048)2.05860702
155protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.05676335
156regulation of fibroblast apoptotic process (GO:2000269)2.05656846
157embryonic retina morphogenesis in camera-type eye (GO:0060059)2.05133125
158embryonic viscerocranium morphogenesis (GO:0048703)2.05101034
159actin-mediated cell contraction (GO:0070252)2.05012974
160regulation of Rac protein signal transduction (GO:0035020)2.04392382
161response to fluid shear stress (GO:0034405)2.04156853
162phospholipid translocation (GO:0045332)2.03803364
163lipid translocation (GO:0034204)2.03803364
164myoblast fusion (GO:0007520)2.03620229
165regulation of ARF protein signal transduction (GO:0032012)2.03367587
166apical protein localization (GO:0045176)2.02554774
167Golgi to endosome transport (GO:0006895)2.02067087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.28798277
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.04466821
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.36473231
4SALL1_21062744_ChIP-ChIP_HESCs_Human4.05180645
5* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.43908681
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.42147719
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.22981325
8* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.10366203
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.75625599
10SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.66799597
11ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.41860656
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38259892
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.35317764
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.35317764
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.35317764
16TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.34610098
17HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.09686890
18HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07758446
19SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.05648117
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.04289364
21ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.03352683
22Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.00546793
23FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99238290
24TP63_17297297_ChIP-ChIP_HaCaT_Human1.99082463
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.93792307
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92136082
27CDX2_19796622_ChIP-Seq_MESCs_Mouse1.90902495
28TP63_19390658_ChIP-ChIP_HaCaT_Human1.87864819
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.87038993
30* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84509023
31AR_21909140_ChIP-Seq_LNCAP_Human1.81253517
32E2F1_21310950_ChIP-Seq_MCF-7_Human1.73087488
33MYC_19079543_ChIP-ChIP_MESCs_Mouse1.72115711
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70682125
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.68730407
36WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68002974
37FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.67830826
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.67256124
39TCF3_18692474_ChIP-Seq_MESCs_Mouse1.66953198
40NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.64912022
41SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64466320
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64419403
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.63890234
44MYC_18555785_ChIP-Seq_MESCs_Mouse1.63640862
45SOX2_18555785_ChIP-Seq_MESCs_Mouse1.62044862
46* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.61616624
47* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60726124
48SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.59475304
49PKCTHETA_26484144_Chip-Seq_BREAST_Human1.59069256
50MYC_22102868_ChIP-Seq_BL_Human1.57240078
51SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.54815244
52DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.54534367
53NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51794606
54POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.51539308
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.48737802
56CLOCK_20551151_ChIP-Seq_293T_Human1.47711070
57ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46351037
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.46343772
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.46269139
60NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44026241
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.43943247
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40345772
63* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.39765751
64SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.39502594
65* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.38680795
66TCF7_22412390_ChIP-Seq_EML_Mouse1.38644213
67* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.35861637
68* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.35699613
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.34829040
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.34511337
71POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.34466253
72EP300_21415370_ChIP-Seq_HL-1_Mouse1.33551295
73PU_27001747_Chip-Seq_BMDM_Mouse1.32967444
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32810167
75* CHD1_26751641_Chip-Seq_LNCaP_Human1.32252799
76PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.30559762
77ZNF263_19887448_ChIP-Seq_K562_Human1.29807822
78IRF8_27001747_Chip-Seq_BMDM_Mouse1.28906044
79TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.28151327
80ISL1_27105846_Chip-Seq_CPCs_Mouse1.24653706
81NRF2_20460467_ChIP-Seq_MEFs_Mouse1.24504548
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.24504548
83GATA1_22025678_ChIP-Seq_K562_Human1.22805365
84KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21472632
85NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21120135
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20632564
87EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.19494089
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.18704201
89MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18424606
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18015119
91SALL4_18804426_ChIP-ChIP_XEN_Mouse1.16738617
92YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15772749
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.15324313
94P300_27058665_Chip-Seq_ZR-75-30cells_Human1.15272640
95RUNX_20019798_ChIP-Seq_JUKART_Human1.15063126
96POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15049814
97AHR_22903824_ChIP-Seq_MCF-7_Human1.14865597
98* BRD4_25478319_ChIP-Seq_HGPS_Human1.14625463
99FOXO3_23340844_ChIP-Seq_DLD1_Human1.14166775
100TBX20_22080862_ChIP-Seq_HEART_Mouse1.13694005
101TBX20_22328084_ChIP-Seq_HEART_Mouse1.13694005
102* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.13359742
103STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.11232826
104VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.10721419
105PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10280722
106BRD4_27068464_Chip-Seq_AML-cells_Mouse1.09989621
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09028067
108POU5F1_16518401_ChIP-PET_MESCs_Mouse1.08949358
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08545724
110* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08206372
111GATA2_21666600_ChIP-Seq_HMVEC_Human1.07765108
112TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07678478
113KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07576333
114TBX3_20139965_ChIP-Seq_ESCs_Mouse1.07512292
115MYC_19030024_ChIP-ChIP_MESCs_Mouse1.07435400
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06966733
117TP53_16413492_ChIP-PET_HCT116_Human1.06254311
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05154512
119MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05071687
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04400190
121VDR_24787735_ChIP-Seq_THP-1_Human1.04255403
122SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02484976
123SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02484976
124* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01911160
125FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.01314432
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.01216450
127TCF4_18268006_ChIP-ChIP_LS174T_Human1.00431842
128FOXA2_19822575_ChIP-Seq_HepG2_Human1.00405906
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00301131
130* KDM2B_26808549_Chip-Seq_DND41_Human0.98973961
131POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98890105
132RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.98362932
133NANOG_16153702_ChIP-ChIP_HESCs_Human0.97562822
134* ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97041401
135* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95917211
136KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95568477
137TP63_23658742_ChIP-Seq_EP156T_Human0.95180801
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95072305
139* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94895144
140KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94648189
141ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93983383
142BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.92407598
143FUS_26573619_Chip-Seq_HEK293_Human0.91993414
144OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91670350
145STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.90683140
146* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.90616847
147KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89339293
148* KDM2B_26808549_Chip-Seq_JURKAT_Human0.89030270
149SOX2_18692474_ChIP-Seq_MESCs_Mouse0.88497680
150FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88377738
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88076040
152PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.87445834
153UBF1/2_26484160_Chip-Seq_HMECs_Human0.87245231
154RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86948257

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.53007018
2MP0000537_abnormal_urethra_morphology3.11268470
3MP0010234_abnormal_vibrissa_follicle3.11080827
4MP0003123_paternal_imprinting2.75681347
5MP0003705_abnormal_hypodermis_morpholog2.74432215
6MP0010352_gastrointestinal_tract_polyps2.55863052
7MP0005076_abnormal_cell_differentiation2.42583177
8MP0003121_genomic_imprinting2.31492006
9MP0003890_abnormal_embryonic-extraembry2.11738840
10MP0010030_abnormal_orbit_morphology2.05105753
11MP0004272_abnormal_basement_membrane2.02565774
12MP0005623_abnormal_meninges_morphology2.01390259
13MP0002084_abnormal_developmental_patter1.98378918
14MP0004197_abnormal_fetal_growth/weight/1.96007030
15MP0002796_impaired_skin_barrier1.94293872
16MP0005451_abnormal_body_composition1.89733588
17MP0003937_abnormal_limbs/digits/tail_de1.89069261
18MP0009053_abnormal_anal_canal1.88762502
19MP0003119_abnormal_digestive_system1.86916319
20MP0001730_embryonic_growth_arrest1.84249770
21MP0005409_darkened_coat_color1.83114535
22MP0003941_abnormal_skin_development1.79829928
23MP0004957_abnormal_blastocyst_morpholog1.79812515
24MP0002254_reproductive_system_inflammat1.76853246
25MP0003122_maternal_imprinting1.75489926
26MP0003111_abnormal_nucleus_morphology1.74657067
27MP0001293_anophthalmia1.74505504
28MP0003077_abnormal_cell_cycle1.74290621
29MP0002085_abnormal_embryonic_tissue1.73273051
30MP0010678_abnormal_skin_adnexa1.72231385
31MP0003828_pulmonary_edema1.71275079
32MP0010094_abnormal_chromosome_stability1.69453982
33MP0000733_abnormal_muscle_development1.67706521
34MP0005187_abnormal_penis_morphology1.67261978
35MP0001672_abnormal_embryogenesis/_devel1.67190474
36MP0005380_embryogenesis_phenotype1.67190474
37MP0000569_abnormal_digit_pigmentation1.65448503
38MP0010307_abnormal_tumor_latency1.64973781
39MP0000428_abnormal_craniofacial_morphol1.64909696
40MP0001849_ear_inflammation1.63410467
41MP0003567_abnormal_fetal_cardiomyocyte1.63146579
42MP0002086_abnormal_extraembryonic_tissu1.61151103
43MP0003385_abnormal_body_wall1.61000805
44MP0003453_abnormal_keratinocyte_physiol1.60974112
45MP0002396_abnormal_hematopoietic_system1.57020716
46MP0002088_abnormal_embryonic_growth/wei1.56094954
47MP0003984_embryonic_growth_retardation1.55234775
48MP0001697_abnormal_embryo_size1.54679890
49MP0006054_spinal_hemorrhage1.52922152
50MP0000350_abnormal_cell_proliferation1.50411982
51MP0003935_abnormal_craniofacial_develop1.49037602
52MP0002697_abnormal_eye_size1.48990311
53MP0003221_abnormal_cardiomyocyte_apopto1.48602193
54MP0002060_abnormal_skin_morphology1.48321933
55MP0002166_altered_tumor_susceptibility1.46844330
56MP0005367_renal/urinary_system_phenotyp1.41409053
57MP0000516_abnormal_urinary_system1.41409053
58MP0009703_decreased_birth_body1.40793839
59MP0008438_abnormal_cutaneous_collagen1.39339520
60MP0008057_abnormal_DNA_replication1.39034412
61MP0005248_abnormal_Harderian_gland1.38880248
62MP0004087_abnormal_muscle_fiber1.38513636
63MP0002092_abnormal_eye_morphology1.37730659
64MP0003566_abnormal_cell_adhesion1.36298109
65MP0004808_abnormal_hematopoietic_stem1.35338580
66MP0004036_abnormal_muscle_relaxation1.32595883
67MP0003755_abnormal_palate_morphology1.32507519
68MP0003115_abnormal_respiratory_system1.31073805
69MP0003763_abnormal_thymus_physiology1.30815136
70MP0000432_abnormal_head_morphology1.28180740
71MP0003191_abnormal_cellular_cholesterol1.27975750
72MP0009672_abnormal_birth_weight1.27692913
73MP0001299_abnormal_eye_distance/1.25641209
74MP0003693_abnormal_embryo_hatching1.24174618
75MP0002925_abnormal_cardiovascular_devel1.21542974
76MP0003861_abnormal_nervous_system1.19759572
77MP0000751_myopathy1.19028668
78MP0003283_abnormal_digestive_organ1.18147977
79MP0002080_prenatal_lethality1.16654965
80MP0000383_abnormal_hair_follicle1.16572875
81MP0005621_abnormal_cell_physiology1.16441975
82MP0008932_abnormal_embryonic_tissue1.16210398
83MP0002877_abnormal_melanocyte_morpholog1.15435402
84MP0003303_peritoneal_inflammation1.14996807
85MP0000759_abnormal_skeletal_muscle1.14057026
86MP0003787_abnormal_imprinting1.13686976
87MP0001286_abnormal_eye_development1.12645733
88MP0002111_abnormal_tail_morphology1.12533862
89MP0003942_abnormal_urinary_system1.12405612
90MP0008260_abnormal_autophagy1.09991434
91MP0001851_eye_inflammation1.06046979
92MP0004130_abnormal_muscle_cell1.05131559
93MP0000534_abnormal_ureter_morphology1.03195921
94MP0003091_abnormal_cell_migration1.02238861
95MP0002932_abnormal_joint_morphology1.01861315
96MP0008007_abnormal_cellular_replicative1.01258763
97MP0002233_abnormal_nose_morphology1.00630248
98MP0002006_tumorigenesis0.99983542
99MP0004133_heterotaxia0.99902387
100MP0000747_muscle_weakness0.99637698
101MP0002998_abnormal_bone_remodeling0.98576919
102MP0002269_muscular_atrophy0.98344147
103MP0004084_abnormal_cardiac_muscle0.96586035
104MP0003172_abnormal_lysosome_physiology0.96222283
105MP0000767_abnormal_smooth_muscle0.94469575
106MP0002116_abnormal_craniofacial_bone0.94240577
107MP0004947_skin_inflammation0.92773334
108MP0005275_abnormal_skin_tensile0.92589345
109MP0002106_abnormal_muscle_physiology0.92508010
110MP0001177_atelectasis0.92288942
111MP0001915_intracranial_hemorrhage0.92232893
112MP0002938_white_spotting0.91609780
113MP0005023_abnormal_wound_healing0.91424566
114MP0003690_abnormal_glial_cell0.91229130
115MP0000377_abnormal_hair_follicle0.91144669
116MP0003448_altered_tumor_morphology0.90763376
117MP0003300_gastrointestinal_ulcer0.90705064
118MP0004233_abnormal_muscle_weight0.90464585
119MP0003315_abnormal_perineum_morphology0.89580945
120MP0004264_abnormal_extraembryonic_tissu0.88533819
121MP0001216_abnormal_epidermal_layer0.87886686
122MP0001958_emphysema0.87677193
123MP0002282_abnormal_trachea_morphology0.87470778
124MP0009250_abnormal_appendicular_skeleto0.86355530
125MP0000749_muscle_degeneration0.86064826
126MP0000462_abnormal_digestive_system0.84615126
127MP0002081_perinatal_lethality0.84552791
128MP0002896_abnormal_bone_mineralization0.84459710
129MP0002332_abnormal_exercise_endurance0.83283265
130MP0009780_abnormal_chondrocyte_physiolo0.83046466
131MP0001784_abnormal_fluid_regulation0.82493845
132MP0002114_abnormal_axial_skeleton0.82489428
133MP0002108_abnormal_muscle_morphology0.82192682
134MP0008877_abnormal_DNA_methylation0.82028370
135MP0000762_abnormal_tongue_morphology0.81364200
136MP0002133_abnormal_respiratory_system0.81092714
137MP0005388_respiratory_system_phenotype0.81092714
138MP0003656_abnormal_erythrocyte_physiolo0.80169421
139MP0004510_myositis0.79344444
140MP0009278_abnormal_bone_marrow0.79272697
141MP0000778_abnormal_nervous_system0.78990967
142MP0000266_abnormal_heart_morphology0.78336238
143MP0005508_abnormal_skeleton_morphology0.78335054
144MP0001340_abnormal_eyelid_morphology0.78116213
145MP0005501_abnormal_skin_physiology0.77962841
146MP0005369_muscle_phenotype0.76276755
147MP0005384_cellular_phenotype0.76084882
148MP0006138_congestive_heart_failure0.75781901
149MP0005503_abnormal_tendon_morphology0.75001952
150MP0010630_abnormal_cardiac_muscle0.74795491
151MP0005391_vision/eye_phenotype0.72768918
152MP0003950_abnormal_plasma_membrane0.72508076
153MP0001614_abnormal_blood_vessel0.71095874

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)3.55841975
2Muscle fiber inclusion bodies (HP:0100299)3.46899132
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.38468468
4Ependymoma (HP:0002888)3.38020338
5Papillary thyroid carcinoma (HP:0002895)3.30941816
6Astrocytoma (HP:0009592)3.26060867
7Abnormality of the astrocytes (HP:0100707)3.26060867
8Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.24446091
9Short 4th metacarpal (HP:0010044)3.24446091
10Difficulty running (HP:0009046)3.16417830
11Colon cancer (HP:0003003)2.94211496
12Subacute progressive viral hepatitis (HP:0006572)2.93934709
13Type 1 muscle fiber predominance (HP:0003803)2.88844332
14Shallow orbits (HP:0000586)2.82643996
15Glioma (HP:0009733)2.65955252
16Neoplasm of the oral cavity (HP:0100649)2.55200422
17Exercise-induced myalgia (HP:0003738)2.54241108
18Volvulus (HP:0002580)2.53132764
19Arterial tortuosity (HP:0005116)2.51637362
20Abnormality of the left ventricular outflow tract (HP:0011103)2.49902547
21Subaortic stenosis (HP:0001682)2.49902547
22Exercise-induced muscle cramps (HP:0003710)2.49776874
23Gastrointestinal carcinoma (HP:0002672)2.46711423
24Malignant gastrointestinal tract tumors (HP:0006749)2.46711423
25Deviation of the thumb (HP:0009603)2.46108866
26Spinal cord lesions (HP:0100561)2.44344030
27Syringomyelia (HP:0003396)2.44344030
28Vertebral arch anomaly (HP:0008438)2.41851731
29Medulloblastoma (HP:0002885)2.41396364
30Proximal placement of thumb (HP:0009623)2.40647945
31Cerebral aneurysm (HP:0004944)2.39734263
32Abnormality of the 4th metacarpal (HP:0010012)2.38939768
33Biliary tract neoplasm (HP:0100574)2.34458292
34Abnormality of the labia minora (HP:0012880)2.31957840
35Absent frontal sinuses (HP:0002688)2.30133174
36Vascular tortuosity (HP:0004948)2.24418252
37Renal duplication (HP:0000075)2.19714452
38Hypoplastic labia majora (HP:0000059)2.15902368
39Skull defect (HP:0001362)2.15839340
40Macroorchidism (HP:0000053)2.14698311
41Esophageal atresia (HP:0002032)2.13745398
42Abnormality of skeletal muscle fiber size (HP:0012084)2.12989241
43Centrally nucleated skeletal muscle fibers (HP:0003687)2.11148810
44Curly hair (HP:0002212)2.07900157
45Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.07397029
46Supernumerary ribs (HP:0005815)2.05532195
47Deep philtrum (HP:0002002)2.05142220
48Broad thumb (HP:0011304)2.04335621
49Ankyloglossia (HP:0010296)2.04055522
50Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03909914
51Neoplasm of striated muscle (HP:0009728)2.03058610
52Increased nuchal translucency (HP:0010880)2.02428957
53Distal arthrogryposis (HP:0005684)2.01191837
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.00192734
55Flat acetabular roof (HP:0003180)1.98498315
56Dysmetric saccades (HP:0000641)1.98397202
57Increased variability in muscle fiber diameter (HP:0003557)1.96658924
58Rectal prolapse (HP:0002035)1.96377268
59Hyporeflexia of lower limbs (HP:0002600)1.95354094
60Osteolytic defects of the phalanges of the hand (HP:0009771)1.94587868
61Osteolytic defects of the hand bones (HP:0009699)1.94587868
62Right ventricular cardiomyopathy (HP:0011663)1.94243877
63Thyroid carcinoma (HP:0002890)1.93859812
64Abnormality of the labia majora (HP:0012881)1.93408418
65Spondylolisthesis (HP:0003302)1.92216789
66Short 1st metacarpal (HP:0010034)1.92172548
67Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.92172548
68Rhabdomyosarcoma (HP:0002859)1.90628997
69Pelvic girdle muscle weakness (HP:0003749)1.89335011
70Selective tooth agenesis (HP:0001592)1.88480115
71Acute myeloid leukemia (HP:0004808)1.87912665
72Transitional cell carcinoma of the bladder (HP:0006740)1.87712969
73Wrist flexion contracture (HP:0001239)1.86715982
74Long eyelashes (HP:0000527)1.86698322
75Hypopigmentation of the fundus (HP:0007894)1.86522950
76Midline defect of the nose (HP:0004122)1.86479181
77Leiomyosarcoma (HP:0100243)1.85046281
78Uterine leiomyosarcoma (HP:0002891)1.85046281
79Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84842974
80Protrusio acetabuli (HP:0003179)1.84658366
81Ankle contracture (HP:0006466)1.83932354
82Bladder carcinoma (HP:0002862)1.83767760
83Bladder neoplasm (HP:0009725)1.83767760
84Hepatoblastoma (HP:0002884)1.83767530
85Dislocated radial head (HP:0003083)1.81688201
86Missing ribs (HP:0000921)1.80827279
87Heterotopia (HP:0002282)1.80689552
88Trigonocephaly (HP:0000243)1.79617916
89Aqueductal stenosis (HP:0002410)1.78811963
90Fibrous tissue neoplasm (HP:0012316)1.78795389
91Uterine neoplasm (HP:0010784)1.78688831
92Abnormality of oral frenula (HP:0000190)1.77685650
93Thickened calvaria (HP:0002684)1.76601356
94Broad face (HP:0000283)1.76590115
95Abnormality of the fingertips (HP:0001211)1.76535399
96Abnormality of the calcaneus (HP:0008364)1.76404352
97Supernumerary bones of the axial skeleton (HP:0009144)1.76318711
98Sandal gap (HP:0001852)1.75457457
99Neonatal hypoglycemia (HP:0001998)1.74291949
100Abnormality of the nasal septum (HP:0000419)1.74099863
101Increased connective tissue (HP:0009025)1.72854258
102Shoulder girdle muscle weakness (HP:0003547)1.71531656
103Fibroma (HP:0010614)1.71416751
104Insidious onset (HP:0003587)1.71159380
105Termporal pattern (HP:0011008)1.71159380
106Advanced eruption of teeth (HP:0006288)1.71093683
107Aortic dissection (HP:0002647)1.70940299
108Broad palm (HP:0001169)1.70458296
109Frequent falls (HP:0002359)1.70255565
110Aortic aneurysm (HP:0004942)1.69747333
111Germ cell neoplasia (HP:0100728)1.69648330
112Short phalanx of the thumb (HP:0009660)1.68754205
113Hematochezia (HP:0002573)1.68514683
114Short humerus (HP:0005792)1.67895865
115Premature rupture of membranes (HP:0001788)1.67367347
116Dilatation of the ascending aorta (HP:0005111)1.66824985
117Overriding aorta (HP:0002623)1.66693669
118Lower limb amyotrophy (HP:0007210)1.66532810
119Obsessive-compulsive behavior (HP:0000722)1.66377895
120Bowel diverticulosis (HP:0005222)1.66316058
121Lymphangioma (HP:0100764)1.65928990
122EMG: myopathic abnormalities (HP:0003458)1.65531703
123Atresia of the external auditory canal (HP:0000413)1.64247460
124Distal lower limb amyotrophy (HP:0008944)1.64182118
125Nephroblastoma (Wilms tumor) (HP:0002667)1.63986357
126Hyperacusis (HP:0010780)1.63969993
127Broad phalanges of the hand (HP:0009768)1.63888386
128Embryonal renal neoplasm (HP:0011794)1.63519938
129T lymphocytopenia (HP:0005403)1.63248089
130Hemangiomatosis (HP:0007461)1.63020088
131Cortical dysplasia (HP:0002539)1.62856981
132Buphthalmos (HP:0000557)1.62270187
133Hypoplasia of the maxilla (HP:0000327)1.62027281
134Mitral valve prolapse (HP:0001634)1.62017403
135Eczematoid dermatitis (HP:0000976)1.61865488
136Aplasia/Hypoplasia of the sternum (HP:0006714)1.61702313
137Aplasia/hypoplasia of the humerus (HP:0006507)1.61689497
138Ulnar bowing (HP:0003031)1.61677029
139Muscle hypertrophy of the lower extremities (HP:0008968)1.61318159
140Cubitus valgus (HP:0002967)1.60748253
141Atrophic scars (HP:0001075)1.60447338
142Coronal craniosynostosis (HP:0004440)1.59156080
143Renovascular hypertension (HP:0100817)1.58495675
144Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.57732187
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.57682933
146Abnormality of the radial head (HP:0003995)1.57570760
147Abnormality of the hip-girdle musculature (HP:0001445)1.57380948
148Abnormality of the musculature of the pelvis (HP:0001469)1.57380948
149Tetraparesis (HP:0002273)1.56319450
150Asymmetry of the thorax (HP:0001555)1.56034166
151Large earlobe (HP:0009748)1.55272673
152Abnormality of the 1st metacarpal (HP:0010009)1.54530837
153Narrow palate (HP:0000189)1.54209641
154Calcaneovalgus deformity (HP:0001848)1.53708242
155Neoplasm of the adrenal cortex (HP:0100641)1.53201584
156Deviation of the hallux (HP:0010051)1.51847949
157Abnormality of the epiphyses of the hand (HP:0005924)1.51348219
158Intestinal polyposis (HP:0200008)1.51287006
159Overgrowth (HP:0001548)1.51095756
160Intestinal polyp (HP:0005266)1.50695005
161Calf muscle hypertrophy (HP:0008981)1.50432150
162Abnormality of the antihelix (HP:0009738)1.50225526
163Increased density of long bones (HP:0006392)1.49488577
164Enlarged penis (HP:0000040)1.49171996
165Hallux valgus (HP:0001822)1.49004499
166Broad finger (HP:0001500)1.48487786
167Relative macrocephaly (HP:0004482)1.48466948
168Spinal rigidity (HP:0003306)1.48068272
169Vertebral fusion (HP:0002948)1.47615427
170Cystic hygroma (HP:0000476)1.47381358
171Aneurysm (HP:0002617)1.46731325
172Asymmetric septal hypertrophy (HP:0001670)1.46439446

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.65949889
2LATS13.12195097
3OBSCN2.85264359
4PKN22.67260677
5CDC72.55885398
6SCYL22.46000601
7FGFR22.32391147
8PRPF4B2.12120371
9EPHA22.05729605
10EEF2K2.04637298
11MAP3K102.00972245
12BRD41.99474489
13NEK21.93734290
14PDGFRA1.93661780
15FGFR41.86350452
16AKT31.76086117
17MAP3K141.65533067
18CDK61.64392310
19ALK1.64000758
20PNCK1.62811728
21NLK1.62563491
22YES11.61713669
23TTN1.58454603
24NEK11.54263349
25FGFR11.53715282
26PTK61.50945629
27TTK1.48565690
28MAP3K131.48044957
29RIPK11.47761938
30SRPK11.45484499
31SGK31.43518614
32STK31.41763690
33MET1.40841327
34PASK1.35048622
35KSR11.34699043
36MTOR1.29952097
37STK38L1.27563820
38FER1.27340232
39MELK1.26852616
40SGK21.25153131
41TYRO31.24351476
42RPS6KB21.23701892
43MKNK11.23386305
44PLK31.22001691
45WNK31.21024844
46TRIB31.19958812
47JAK11.17037132
48LATS21.16762101
49WEE11.16420977
50EPHB21.15992554
51CSNK1A1L1.13559196
52SMG11.13363111
53STK101.12105652
54ICK1.12045064
55CAMK1D1.09666039
56CHEK11.07808070
57MAP3K81.07303308
58PDGFRB1.03921435
59FRK1.02739945
60MAP3K71.01708666
61DDR21.01272960
62BCR0.99036982
63TYK20.98958282
64CSNK1D0.98628204
65CAMK1G0.97474624
66PAK40.95520705
67MAP2K30.94588917
68ATM0.93988400
69FGFR30.93099582
70STK240.91877029
71MAP3K20.89747207
72EIF2AK30.89200790
73CDK40.88388639
74ATR0.88286384
75CHEK20.87490044
76MAP3K60.85160680
77CDK90.85036798
78MAPK70.84295933
79PLK10.84116309
80DMPK0.83659521
81TRPM70.82694682
82PIK3CG0.82027107
83MKNK20.81804723
84TSSK60.79886217
85PAK20.79725510
86CDK20.79287910
87MAP3K10.79246815
88CSK0.79078489
89ZAP700.78133987
90DYRK30.76519790
91RET0.75865331
92EPHA30.75530943
93TGFBR10.74176925
94MOS0.73194391
95AURKB0.72859551
96MARK10.72215960
97TEC0.71586907
98CDK10.70875931
99SIK30.70842562
100STK40.69422987
101CSNK1E0.68200366
102SGK4940.67864737
103SGK2230.67864737
104ERBB20.67226503
105PRKDC0.67167407
106NEK60.67122475
107CSNK1G10.67025104
108FLT30.66018920
109DYRK1B0.64461228
110EPHB10.63964857
111MARK20.63219137
112BRSK20.62695157
113ERBB30.62230588
114TLK10.62060878
115STK380.61602339
116BMX0.61492701
117PTK20.61406093
118MAP3K30.61182091
119AKT20.59520431
120LRRK20.59064327
121CDK70.58155703
122WNK10.57078557
123HCK0.56776659
124RAF10.55701525
125ZAK0.54815206
126FGR0.54234415
127CSNK1G20.54118644
128JAK20.54040093
129TGFBR20.53837295
130IRAK20.53604851
131CSNK1G30.52914531
132IRAK10.52783013
133ITK0.52772355
134TAF10.51800951
135KSR20.51293419
136MAPK140.50393473
137RPS6KB10.49794103
138PRKD30.49555322
139MAPK100.48671875
140MAP3K90.47838549
141PRKAA20.47820959
142PIK3CA0.47038502
143SIK10.46731574
144NEK90.46715542
145PAK30.46112602
146INSR0.45788879
147GSK3B0.43587799
148EGFR0.43580316
149NTRK10.42585445
150AKT10.41893409
151STK110.41328620
152ERBB40.38941306
153HIPK20.37851865
154JAK30.37019230
155CDC42BPA0.36990343

Predicted pathways (KEGG)

RankGene SetZ-score
1Hippo signaling pathway_Homo sapiens_hsa043902.12445576
2Adherens junction_Homo sapiens_hsa045202.06754190
3Basal cell carcinoma_Homo sapiens_hsa052172.05012210
4mRNA surveillance pathway_Homo sapiens_hsa030152.00875378
5RNA transport_Homo sapiens_hsa030131.96079840
6MicroRNAs in cancer_Homo sapiens_hsa052061.91766188
7Cell cycle_Homo sapiens_hsa041101.87928919
8Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.83191714
9Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.71304536
10Colorectal cancer_Homo sapiens_hsa052101.68155586
11mTOR signaling pathway_Homo sapiens_hsa041501.67565964
12TGF-beta signaling pathway_Homo sapiens_hsa043501.65943751
13Tight junction_Homo sapiens_hsa045301.65738342
14Small cell lung cancer_Homo sapiens_hsa052221.63256524
15Proteoglycans in cancer_Homo sapiens_hsa052051.58381539
16Systemic lupus erythematosus_Homo sapiens_hsa053221.57566006
17Endometrial cancer_Homo sapiens_hsa052131.54514211
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.52793706
19Spliceosome_Homo sapiens_hsa030401.52459176
20Hedgehog signaling pathway_Homo sapiens_hsa043401.52425950
21Acute myeloid leukemia_Homo sapiens_hsa052211.48957977
22Focal adhesion_Homo sapiens_hsa045101.47748331
23Circadian rhythm_Homo sapiens_hsa047101.47343714
24ECM-receptor interaction_Homo sapiens_hsa045121.46619343
25Renal cell carcinoma_Homo sapiens_hsa052111.46531694
26Chronic myeloid leukemia_Homo sapiens_hsa052201.45828479
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42244457
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.40005643
29Viral carcinogenesis_Homo sapiens_hsa052031.39321541
30Wnt signaling pathway_Homo sapiens_hsa043101.36518147
31Oocyte meiosis_Homo sapiens_hsa041141.35340036
32Axon guidance_Homo sapiens_hsa043601.34875833
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34015723
34Mismatch repair_Homo sapiens_hsa034301.32857495
35Prolactin signaling pathway_Homo sapiens_hsa049171.29371945
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27170051
37Prostate cancer_Homo sapiens_hsa052151.26989713
38B cell receptor signaling pathway_Homo sapiens_hsa046621.26003760
39One carbon pool by folate_Homo sapiens_hsa006701.23507331
40Alcoholism_Homo sapiens_hsa050341.21234952
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20828339
42Inositol phosphate metabolism_Homo sapiens_hsa005621.19817984
43HTLV-I infection_Homo sapiens_hsa051661.18821359
44Dorso-ventral axis formation_Homo sapiens_hsa043201.17232925
45Viral myocarditis_Homo sapiens_hsa054161.15874736
46Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14519288
47Glioma_Homo sapiens_hsa052141.13388518
48Pathways in cancer_Homo sapiens_hsa052001.11636987
49Osteoclast differentiation_Homo sapiens_hsa043801.09570955
50p53 signaling pathway_Homo sapiens_hsa041151.09242387
51Central carbon metabolism in cancer_Homo sapiens_hsa052301.09043051
52Non-small cell lung cancer_Homo sapiens_hsa052231.09028331
53Lysine degradation_Homo sapiens_hsa003101.04858012
54Leukocyte transendothelial migration_Homo sapiens_hsa046701.04758874
55Notch signaling pathway_Homo sapiens_hsa043301.02852442
56Thyroid cancer_Homo sapiens_hsa052161.01709324
57Pancreatic cancer_Homo sapiens_hsa052121.01088231
58Hepatitis C_Homo sapiens_hsa051601.00014415
59GnRH signaling pathway_Homo sapiens_hsa049120.97439661
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.96861396
61ErbB signaling pathway_Homo sapiens_hsa040120.96064649
62Long-term potentiation_Homo sapiens_hsa047200.95145642
63Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93634184
64Melanogenesis_Homo sapiens_hsa049160.93054152
65Bladder cancer_Homo sapiens_hsa052190.92193110
66Measles_Homo sapiens_hsa051620.91395438
67Transcriptional misregulation in cancer_Homo sapiens_hsa052020.90650324
68Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.89727526
69FoxO signaling pathway_Homo sapiens_hsa040680.89456835
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.88314802
71Toll-like receptor signaling pathway_Homo sapiens_hsa046200.88086169
72Estrogen signaling pathway_Homo sapiens_hsa049150.87293333
73Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86708792
74Rap1 signaling pathway_Homo sapiens_hsa040150.84813344
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.84580795
76DNA replication_Homo sapiens_hsa030300.84260741
77Melanoma_Homo sapiens_hsa052180.84073359
78PI3K-Akt signaling pathway_Homo sapiens_hsa041510.83576226
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83469064
80Non-homologous end-joining_Homo sapiens_hsa034500.81257754
81TNF signaling pathway_Homo sapiens_hsa046680.80994326
82Type II diabetes mellitus_Homo sapiens_hsa049300.80421252
83AMPK signaling pathway_Homo sapiens_hsa041520.80048149
84Fanconi anemia pathway_Homo sapiens_hsa034600.77464535
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.77321129
86Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77098319
87RNA degradation_Homo sapiens_hsa030180.77017829
88Influenza A_Homo sapiens_hsa051640.76205573
89VEGF signaling pathway_Homo sapiens_hsa043700.75921768
90Glucagon signaling pathway_Homo sapiens_hsa049220.75384870
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74981503
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72182681
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71534530
94Dilated cardiomyopathy_Homo sapiens_hsa054140.69648430
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.69625177
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69334567
97Amoebiasis_Homo sapiens_hsa051460.68013377
98Shigellosis_Homo sapiens_hsa051310.67448915
99HIF-1 signaling pathway_Homo sapiens_hsa040660.67145090
100Nucleotide excision repair_Homo sapiens_hsa034200.66741954
101Leishmaniasis_Homo sapiens_hsa051400.64730563
102Legionellosis_Homo sapiens_hsa051340.64319300
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.64176450
104Chemokine signaling pathway_Homo sapiens_hsa040620.64172580
105Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63898903
106MAPK signaling pathway_Homo sapiens_hsa040100.63277741
107Insulin signaling pathway_Homo sapiens_hsa049100.62842445
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.61904629
109T cell receptor signaling pathway_Homo sapiens_hsa046600.61663307
110Choline metabolism in cancer_Homo sapiens_hsa052310.61244869
111Tuberculosis_Homo sapiens_hsa051520.60913925
112Toxoplasmosis_Homo sapiens_hsa051450.60792950
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60764978
114Gap junction_Homo sapiens_hsa045400.59918143
115Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59882501
116Other glycan degradation_Homo sapiens_hsa005110.59674511
117Epstein-Barr virus infection_Homo sapiens_hsa051690.58884947
118Insulin resistance_Homo sapiens_hsa049310.58692288
119Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58519358
120Endocytosis_Homo sapiens_hsa041440.58352685
121Hepatitis B_Homo sapiens_hsa051610.58206802
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58040474
123Long-term depression_Homo sapiens_hsa047300.57739175
124Herpes simplex infection_Homo sapiens_hsa051680.57637336
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.57137741
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56858804
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55863851
128Ras signaling pathway_Homo sapiens_hsa040140.54691711
129cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54159653
130Platelet activation_Homo sapiens_hsa046110.54141010

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