TNIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of vitamin D biosynthetic process (GO:0060556)6.97906815
2antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.12578265
3neutrophil activation involved in immune response (GO:0002283)5.53200131
4negative regulation of interleukin-12 production (GO:0032695)5.49698153
5regulation of vitamin metabolic process (GO:0030656)5.47066941
6regulation of cytokine secretion involved in immune response (GO:0002739)5.46489992
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.26066891
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.26066891
9modulation by symbiont of host immune response (GO:0052553)5.26066891
10positive regulation by symbiont of host defense response (GO:0052509)5.26066891
11modulation by symbiont of host defense response (GO:0052031)5.26066891
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.26066891
13branching involved in labyrinthine layer morphogenesis (GO:0060670)5.15826924
14response to peptidoglycan (GO:0032494)4.99855677
15regulation of activation of Janus kinase activity (GO:0010533)4.57224506
16natural killer cell mediated immunity (GO:0002228)4.51957274
17natural killer cell mediated cytotoxicity (GO:0042267)4.51957274
18response to muramyl dipeptide (GO:0032495)4.51843299
19regulation of podosome assembly (GO:0071801)4.47437986
20T-helper 1 type immune response (GO:0042088)4.39468502
21negative regulation of interleukin-17 production (GO:0032700)4.38054638
22positive regulation of interferon-alpha production (GO:0032727)4.28909677
23positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.17617598
24defense response to protozoan (GO:0042832)4.17400800
25positive regulation of cellular amide metabolic process (GO:0034250)4.14433966
26negative regulation of cytokine production involved in immune response (GO:0002719)4.11290735
27regulation of immunoglobulin secretion (GO:0051023)4.09871560
28regulation of interferon-alpha production (GO:0032647)4.06803130
29positive regulation of interleukin-12 production (GO:0032735)4.06357143
30macrophage activation involved in immune response (GO:0002281)4.01695495
31cellular response to nicotine (GO:0071316)4.00743344
32positive regulation of gamma-delta T cell activation (GO:0046645)3.98460637
33neutrophil activation (GO:0042119)3.95170007
34positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.94874615
35granulocyte activation (GO:0036230)3.94406753
36positive regulation of heat generation (GO:0031652)3.90767547
37immunoglobulin mediated immune response (GO:0016064)3.89766097
38regulation of membrane protein ectodomain proteolysis (GO:0051043)3.84775184
39lipopolysaccharide-mediated signaling pathway (GO:0031663)3.82071552
40regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.79006262
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.78685944
42response to host immune response (GO:0052572)3.78685944
43regulation of T-helper 1 cell differentiation (GO:0045625)3.76662310
44regulation of interleukin-12 biosynthetic process (GO:0045075)3.76406672
45positive regulation of NF-kappaB import into nucleus (GO:0042346)3.74938488
46positive regulation of defense response to virus by host (GO:0002230)3.74672831
47regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.72145193
48negative regulation of nitric oxide biosynthetic process (GO:0045019)3.71934535
49NIK/NF-kappaB signaling (GO:0038061)3.71662464
50type I interferon signaling pathway (GO:0060337)3.71259958
51cellular response to type I interferon (GO:0071357)3.71259958
52regulation of interferon-beta biosynthetic process (GO:0045357)3.68036218
53positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.67400153
54response to type I interferon (GO:0034340)3.66632217
55positive regulation of nitric oxide biosynthetic process (GO:0045429)3.64686104
56neutrophil mediated immunity (GO:0002446)3.64505199
57regulation of nitric oxide biosynthetic process (GO:0045428)3.62649159
58respiratory burst (GO:0045730)3.60375662
59modulation by symbiont of host cellular process (GO:0044068)3.58174077
60positive regulation of alpha-beta T cell proliferation (GO:0046641)3.55447000
61response to protozoan (GO:0001562)3.55077287
62myeloid dendritic cell differentiation (GO:0043011)3.54770610
63negative regulation of amino acid transport (GO:0051956)3.54351733
64positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.49107596
65hydrogen peroxide biosynthetic process (GO:0050665)3.48689968
66regulation of interleukin-17 production (GO:0032660)3.46041943
67regulation of fever generation (GO:0031620)3.45522375
68regulation of alpha-beta T cell proliferation (GO:0046640)3.44681076
69superoxide anion generation (GO:0042554)3.44288305
70myeloid dendritic cell activation (GO:0001773)3.43685569
71positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.42431693
72positive regulation of chemokine biosynthetic process (GO:0045080)3.41183138
73cellular response to interferon-beta (GO:0035458)3.40503105
74modulation of growth of symbiont involved in interaction with host (GO:0044144)3.39852327
75regulation of growth of symbiont in host (GO:0044126)3.39852327
76negative regulation of growth of symbiont in host (GO:0044130)3.39852327
77negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.39852327
78myeloid cell activation involved in immune response (GO:0002275)3.39764437
79leukocyte mediated cytotoxicity (GO:0001909)3.38535068
80regulation of T-helper cell differentiation (GO:0045622)3.38214396
81cellular response to virus (GO:0098586)3.37559960
82positive regulation of interleukin-17 production (GO:0032740)3.36745435
83positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.36718719
84regulation of interleukin-8 biosynthetic process (GO:0045414)3.36478903
85negative regulation of production of molecular mediator of immune response (GO:0002701)3.35689453
86positive regulation of interferon-beta production (GO:0032728)3.34310902
87positive regulation of interleukin-1 beta secretion (GO:0050718)3.32113133
88response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.32092314
89response to host (GO:0075136)3.32092314
90response to host defenses (GO:0052200)3.32092314
91CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.31567673
92interferon-gamma-mediated signaling pathway (GO:0060333)3.29737266
93negative regulation of viral genome replication (GO:0045071)3.28473977
94regulation of NF-kappaB import into nucleus (GO:0042345)3.28190609
95positive regulation of antigen processing and presentation (GO:0002579)3.27758399
96regulation of inflammatory response to antigenic stimulus (GO:0002861)3.26083206
97positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.25671093
98positive regulation of acute inflammatory response (GO:0002675)3.25008501
99positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.24944922
100microglial cell activation (GO:0001774)3.23562433
101regulation of interleukin-1 beta secretion (GO:0050706)3.22083070
102regulation of dendritic cell antigen processing and presentation (GO:0002604)3.21343194
103positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.20712870
104cytokine secretion (GO:0050663)3.19442229
105regulation of interleukin-12 production (GO:0032655)3.18527682
106positive regulation of T-helper cell differentiation (GO:0045624)3.18445571
107response to interferon-alpha (GO:0035455)3.18204076
108regulation of heterotypic cell-cell adhesion (GO:0034114)3.17449378
109negative regulation of T cell mediated immunity (GO:0002710)3.16992258
110germinal center formation (GO:0002467)3.14951056
111regulation of interleukin-2 biosynthetic process (GO:0045076)3.12548336
112* cellular response to lipopolysaccharide (GO:0071222)3.12261552
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.12072873
114response to interferon-beta (GO:0035456)3.11372552
115kynurenine metabolic process (GO:0070189)3.09093105
116regulation of RIG-I signaling pathway (GO:0039535)3.08047455
117positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.07877308
118positive regulation of interleukin-1 secretion (GO:0050716)3.07379873
119positive regulation of type 2 immune response (GO:0002830)3.06003692
120negative regulation of lipid storage (GO:0010888)3.05881113
121negative regulation of inflammatory response to antigenic stimulus (GO:0002862)3.05151943
122monocyte chemotaxis (GO:0002548)3.04961696
123myeloid leukocyte mediated immunity (GO:0002444)3.04722287
124regulation of T-helper 1 type immune response (GO:0002825)3.04438786
125reactive oxygen species biosynthetic process (GO:1903409)3.04321659
126regulation of mononuclear cell migration (GO:0071675)3.03958857
127* cellular response to molecule of bacterial origin (GO:0071219)3.03071544
128tryptophan catabolic process (GO:0006569)3.02107382
129indole-containing compound catabolic process (GO:0042436)3.02107382
130indolalkylamine catabolic process (GO:0046218)3.02107382
131adhesion of symbiont to host cell (GO:0044650)3.01404483
132virion attachment to host cell (GO:0019062)3.01404483
133positive regulation of natural killer cell differentiation (GO:0032825)3.01384037
134regulation of chronic inflammatory response (GO:0002676)3.01250620
135regulation of memory T cell differentiation (GO:0043380)2.99531834
136regulation of lymphocyte chemotaxis (GO:1901623)2.98961497
137regulation of chemokine biosynthetic process (GO:0045073)2.97522380
138detection of molecule of bacterial origin (GO:0032490)2.96792958
139regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.95684513
140activation of MAPKKK activity (GO:0000185)2.95250842
141B cell mediated immunity (GO:0019724)2.95242495
142dendritic cell differentiation (GO:0097028)2.94307093
143positive regulation of humoral immune response (GO:0002922)2.93003964
144positive regulation of T-helper 1 type immune response (GO:0002827)2.92636828
145positive regulation of interleukin-10 production (GO:0032733)2.92583730
146I-kappaB phosphorylation (GO:0007252)2.91681410
147adaptive immune response based on somatic recombination of immune receptors built from immunoglobuli2.91635708
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.90870615
149positive regulation of interleukin-6 production (GO:0032755)2.89908191
150regulation of heat generation (GO:0031650)2.89868617
151positive regulation of B cell mediated immunity (GO:0002714)2.89733478
152positive regulation of immunoglobulin mediated immune response (GO:0002891)2.89733478
153negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88940079
154interferon-gamma secretion (GO:0072643)2.86494403
155response to ATP (GO:0033198)2.85646865
156regulation of type 2 immune response (GO:0002828)2.85156698
157cellular response to ATP (GO:0071318)2.85136902
158negative regulation of myeloid cell apoptotic process (GO:0033033)2.85026365
159lymphocyte chemotaxis (GO:0048247)2.84699189
160regulation of interferon-gamma biosynthetic process (GO:0045072)2.83281957

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.21981915
2IRF8_21731497_ChIP-ChIP_J774_Mouse7.13461547
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.03108535
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.48025290
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.44061571
6* IRF8_27001747_Chip-Seq_BMDM_Mouse4.38502633
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.25822462
8Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse4.09551545
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.58499997
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.43361526
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.34121128
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.27379486
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.12446804
14MYB_21317192_ChIP-Seq_ERMYB_Mouse2.91475805
15* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.88749237
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67213668
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55615411
18SCL_19346495_ChIP-Seq_HPC-7_Human2.41175349
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.25412477
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.18729587
21* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse2.07511856
22SPI1_23547873_ChIP-Seq_NB4_Human2.06578158
23* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.96074961
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.95363013
25VDR_24787735_ChIP-Seq_THP-1_Human1.93094638
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78895917
27* PU_27001747_Chip-Seq_BMDM_Mouse1.76929838
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73622930
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.70767213
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.70402800
31SPI1_23127762_ChIP-Seq_K562_Human1.69299511
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.69174865
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.60614392
34VDR_24763502_ChIP-Seq_THP-1_Human1.58993653
35RUNX_20019798_ChIP-Seq_JUKART_Human1.57415400
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53253668
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.52179050
38CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.52166076
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.51911200
40MYB_26560356_Chip-Seq_TH2_Human1.49527764
41MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.48608744
42* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47087111
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.43232630
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41814475
45RUNX1_22412390_ChIP-Seq_EML_Mouse1.39753097
46VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.35743152
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.35274962
48TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33569152
49CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31377358
50MYB_26560356_Chip-Seq_TH1_Human1.27255210
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27054852
52* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25629238
53STAT1_20625510_ChIP-Seq_HELA_Human1.24764801
54GATA3_26560356_Chip-Seq_TH2_Human1.23912638
55* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23267693
56CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.21356423
57* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.20539879
58MAF_26560356_Chip-Seq_TH1_Human1.20206562
59NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17935223
60* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17094075
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16896923
62* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15580970
63* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11670094
64SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.11048915
65ESR2_21235772_ChIP-Seq_MCF-7_Human1.09322391
66* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09001633
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08054120
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08054120
69KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08054120
70ESR1_21235772_ChIP-Seq_MCF-7_Human1.05228781
71GATA3_27048872_Chip-Seq_THYMUS_Human1.04159679
72* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99609519
73* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96430279
74FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.96023089
75* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.90460540
76CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.90322621
77GATA1_22025678_ChIP-Seq_K562_Human0.90235390
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89411811
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88690985
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.88121914
81VDR_21846776_ChIP-Seq_THP-1_Human0.87842156
82NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.87513445
83NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87513445
84CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.85232814
85IGF1R_20145208_ChIP-Seq_DFB_Human0.85148184
86GATA1_19941826_ChIP-Seq_K562_Human0.83079670
87JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82746760
88SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.82726918
89SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80731267
90SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80731267
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80029023
92TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79537714
93EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.78175303
94CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77195893
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76324397
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.75180407
97GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75101174
98SOX2_20726797_ChIP-Seq_SW620_Human0.74292329
99MAF_26560356_Chip-Seq_TH2_Human0.74285140
100TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71855260
101TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.71374850
102PU1_27457419_Chip-Seq_LIVER_Mouse0.70983130
103JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67449432
104TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.66678123
105FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.65239022
106KDM2B_26808549_Chip-Seq_SUP-B15_Human0.65133156
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.64793366
108SMRT_27268052_Chip-Seq_Bcells_Human0.64098200
109STAT3_18555785_Chip-Seq_ESCs_Mouse0.63166151
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.62843398
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.62830443
112EGR1_23403033_ChIP-Seq_LIVER_Mouse0.62549063
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.62185484
114EGR1_19032775_ChIP-ChIP_M12_Human0.61781322
115GATA1_19941827_ChIP-Seq_MEL86_Mouse0.61114147
116IKZF1_21737484_ChIP-ChIP_HCT116_Human0.60694960
117SMAD1_18555785_Chip-Seq_ESCs_Mouse0.60588238
118UTX_26944678_Chip-Seq_JUKART_Human0.60495814
119GATA2_19941826_ChIP-Seq_K562_Human0.59979513
120BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.59938669
121PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59685423
122BCOR_27268052_Chip-Seq_Bcells_Human0.59026678
123SUZ12_18555785_Chip-Seq_ESCs_Mouse0.58719508
124BCL6_27268052_Chip-Seq_Bcells_Human0.58422393
125NMYC_18555785_Chip-Seq_ESCs_Mouse0.57820361
126CMYC_18555785_Chip-Seq_ESCs_Mouse0.57349503
127GATA1_22383799_ChIP-Seq_G1ME_Mouse0.57215427
128PCGF2_27294783_Chip-Seq_ESCs_Mouse0.56876554
129EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.56512944

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.95000435
2MP0000569_abnormal_digit_pigmentation4.54785819
3MP0009785_altered_susceptibility_to4.11030163
4MP0002148_abnormal_hypersensitivity_rea3.68457811
5MP0003436_decreased_susceptibility_to3.60040400
6MP0004510_myositis3.24473644
7MP0000685_abnormal_immune_system3.21842119
8MP0002419_abnormal_innate_immunity3.16143868
9MP0005000_abnormal_immune_tolerance3.15149808
10MP0005025_abnormal_response_to3.07298519
11MP0005387_immune_system_phenotype2.86172384
12MP0001790_abnormal_immune_system2.86172384
13MP0005671_abnormal_response_to2.84871019
14MP0006082_CNS_inflammation2.78830045
15MP0002452_abnormal_antigen_presenting2.71324591
16MP0001800_abnormal_humoral_immune2.64321113
17MP0002723_abnormal_immune_serum2.62388379
18MP0003724_increased_susceptibility_to2.52865461
19MP0002139_abnormal_hepatobiliary_system2.40656621
20MP0003303_peritoneal_inflammation2.38040776
21MP0005058_abnormal_lysosome_morphology2.33573156
22MP0009278_abnormal_bone_marrow2.26988309
23MP0001819_abnormal_immune_cell2.26312619
24MP0005174_abnormal_tail_pigmentation2.23295613
25MP0002420_abnormal_adaptive_immunity2.21587706
26MP0003172_abnormal_lysosome_physiology2.13282042
27MP0004947_skin_inflammation2.11951752
28MP0005464_abnormal_platelet_physiology2.10022426
29MP0003195_calcinosis2.09233356
30MP0008004_abnormal_stomach_pH2.04929640
31MP0002006_tumorigenesis2.03653709
32MP0009764_decreased_sensitivity_to1.96230047
33MP0001853_heart_inflammation1.78667975
34MP0003448_altered_tumor_morphology1.77380831
35MP0002405_respiratory_system_inflammati1.76784219
36MP0010155_abnormal_intestine_physiology1.75263784
37MP0001845_abnormal_inflammatory_respons1.74843972
38MP0000015_abnormal_ear_pigmentation1.73877217
39MP0005397_hematopoietic_system_phenotyp1.71335901
40MP0001545_abnormal_hematopoietic_system1.71335901
41MP0001533_abnormal_skeleton_physiology1.68251956
42MP0001501_abnormal_sleep_pattern1.67754009
43MP0006054_spinal_hemorrhage1.62295913
44MP0005451_abnormal_body_composition1.61770371
45MP0002166_altered_tumor_susceptibility1.60930907
46MP0008469_abnormal_protein_level1.58969413
47MP0000716_abnormal_immune_system1.58159286
48MP0005310_abnormal_salivary_gland1.51666408
49MP0002398_abnormal_bone_marrow1.51327777
50MP0003183_abnormal_peptide_metabolism1.47277941
51MP0003646_muscle_fatigue1.41483281
52MP0003075_altered_response_to1.40401011
53MP0003806_abnormal_nucleotide_metabolis1.40036677
54MP0000858_altered_metastatic_potential1.35047263
55MP0000343_altered_response_to1.33581539
56MP0002998_abnormal_bone_remodeling1.27281898
57MP0000689_abnormal_spleen_morphology1.22614477
58MP0002429_abnormal_blood_cell1.21663441
59MP0000371_diluted_coat_color1.16745178
60MP0002277_abnormal_respiratory_mucosa1.15545527
61MP0008260_abnormal_autophagy1.13990336
62MP0009333_abnormal_splenocyte_physiolog1.10530294
63MP0002254_reproductive_system_inflammat1.09582777
64MP0009763_increased_sensitivity_to1.09033027
65MP0002722_abnormal_immune_system1.08150215
66MP0000604_amyloidosis1.07115108
67MP0005166_decreased_susceptibility_to1.06823668
68MP0005167_abnormal_blood-brain_barrier1.05430809
69MP0001663_abnormal_digestive_system1.03757194
70MP0001542_abnormal_bone_strength0.94464522
71MP0002138_abnormal_hepatobiliary_system0.93806305
72MP0010307_abnormal_tumor_latency0.92134148
73MP0004782_abnormal_surfactant_physiolog0.90975514
74MP0005165_increased_susceptibility_to0.87514970
75MP0003191_abnormal_cellular_cholesterol0.87509266
76MP0004808_abnormal_hematopoietic_stem0.85901634
77MP0003763_abnormal_thymus_physiology0.83503260
78MP0003091_abnormal_cell_migration0.83417206
79MP0003690_abnormal_glial_cell0.81643515
80MP0005164_abnormal_response_to0.80324080
81MP0005076_abnormal_cell_differentiation0.80236745
82MP0003566_abnormal_cell_adhesion0.79295403
83MP0004381_abnormal_hair_follicle0.78744027
84MP0003828_pulmonary_edema0.77757008
85MP0005535_abnormal_body_temperature0.77522096
86MP0005390_skeleton_phenotype0.76852641
87MP0001851_eye_inflammation0.76666009
88MP0005647_abnormal_sex_gland0.76235442
89MP0003453_abnormal_keratinocyte_physiol0.75449540
90MP0002837_dystrophic_cardiac_calcinosis0.74948895
91MP0009840_abnormal_foam_cell0.73745696
92MP0003866_abnormal_defecation0.71836268
93MP0001873_stomach_inflammation0.71748534
94MP0003300_gastrointestinal_ulcer0.71642002
95MP0001958_emphysema0.70484700
96MP0003656_abnormal_erythrocyte_physiolo0.70132714
97MP0005266_abnormal_metabolism0.70124191
98MP0002653_abnormal_ependyma_morphology0.68011041
99MP0002933_joint_inflammation0.67055976
100MP0001764_abnormal_homeostasis0.66967179
101MP0000490_abnormal_crypts_of0.66709361
102MP0005257_abnormal_intraocular_pressure0.65845157
103MP0005075_abnormal_melanosome_morpholog0.65619629
104MP0009765_abnormal_xenobiotic_induced0.64468318
105MP0000249_abnormal_blood_vessel0.64433007
106MP0008874_decreased_physiological_sensi0.64223319
107MP0002396_abnormal_hematopoietic_system0.61423803
108MP0002095_abnormal_skin_pigmentation0.61247216
109MP0002693_abnormal_pancreas_physiology0.61058272
110MP0005408_hypopigmentation0.60953002
111MP0000703_abnormal_thymus_morphology0.59868327
112MP0002163_abnormal_gland_morphology0.59495473
113MP0005381_digestive/alimentary_phenotyp0.59481289
114MP0002332_abnormal_exercise_endurance0.58513858
115MP0000767_abnormal_smooth_muscle0.57767354
116MP0000920_abnormal_myelination0.56604236
117MP0001919_abnormal_reproductive_system0.56490923
118MP0005171_absent_coat_pigmentation0.55032819
119MP0001346_abnormal_lacrimal_gland0.54633856
120MP0004043_abnormal_pH_regulation0.54025210
121MP0003045_fibrosis0.53695441
122MP0001348_abnormal_lacrimal_gland0.53605121
123MP0005023_abnormal_wound_healing0.53142369
124MP0000372_irregular_coat_pigmentation0.52614219
125MP0003950_abnormal_plasma_membrane0.51131658
126MP0005595_abnormal_vascular_smooth0.51045196
127MP0000627_abnormal_mammary_gland0.50288464
128MP0005410_abnormal_fertilization0.48856235
129MP0010352_gastrointestinal_tract_polyps0.47997042
130MP0005448_abnormal_energy_balance0.46511917
131MP0005319_abnormal_enzyme/_coenzyme0.45944189

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)7.69467569
2Recurrent bacterial skin infections (HP:0005406)7.49026591
3Eczematoid dermatitis (HP:0000976)6.40529677
4Elevated erythrocyte sedimentation rate (HP:0003565)5.85304870
5Recurrent gram-negative bacterial infections (HP:0005420)5.47130288
6Mediastinal lymphadenopathy (HP:0100721)5.27334641
7Stomatitis (HP:0010280)5.21200385
8Abnormality of macrophages (HP:0004311)4.87762509
9Prostate neoplasm (HP:0100787)4.77769527
10Recurrent skin infections (HP:0001581)4.63367837
11Optic neuritis (HP:0100653)4.48861531
12Retrobulbar optic neuritis (HP:0100654)4.48861531
13Myositis (HP:0100614)4.43090185
14Gingivitis (HP:0000230)4.34762020
15Orchitis (HP:0100796)4.28748790
16Autoimmune thrombocytopenia (HP:0001973)4.15509490
17Vasculitis (HP:0002633)4.09958880
18Recurrent fungal infections (HP:0002841)4.01315965
19Loss of speech (HP:0002371)3.95535569
20Increased IgM level (HP:0003496)3.93895548
21Dysostosis multiplex (HP:0000943)3.89337089
22Periodontitis (HP:0000704)3.79277815
23Thick nail (HP:0001805)3.71981973
24Mutism (HP:0002300)3.65556028
25Vacuolated lymphocytes (HP:0001922)3.46430245
26Obstructive lung disease (HP:0006536)3.44454894
27Chronic obstructive pulmonary disease (HP:0006510)3.44454894
28Recurrent viral infections (HP:0004429)3.36520212
29Chronic mucocutaneous candidiasis (HP:0002728)3.30233351
30Recurrent cutaneous fungal infections (HP:0011370)3.30233351
31T lymphocytopenia (HP:0005403)3.27254398
32Nuclear cataract (HP:0100018)3.21280771
33Parakeratosis (HP:0001036)3.20561481
34Pustule (HP:0200039)3.16954460
35Basal ganglia calcification (HP:0002135)3.11338793
36Leukocytosis (HP:0001974)2.99263907
37Gastrointestinal infarctions (HP:0005244)2.98068055
38Abnormality of mucopolysaccharide metabolism (HP:0011020)2.96305010
39Abnormality of polysaccharide metabolism (HP:0011012)2.96305010
40Abnormality of glycosaminoglycan metabolism (HP:0004371)2.96305010
41Pulmonary infiltrates (HP:0002113)2.93621622
42Urticaria (HP:0001025)2.92103028
43Increased cerebral lipofuscin (HP:0011813)2.89220365
44Premature loss of primary teeth (HP:0006323)2.88341739
45Increased neuronal autofluorescent lipopigment (HP:0002074)2.85746854
46Increased serum ferritin (HP:0003281)2.84445653
47Cellulitis (HP:0100658)2.79652737
48Amyloidosis (HP:0011034)2.79261360
49Nausea (HP:0002018)2.78473913
50Encephalitis (HP:0002383)2.77650073
51Axonal loss (HP:0003447)2.75186490
52Abnormality of the prostate (HP:0008775)2.72949303
53Gingival bleeding (HP:0000225)2.71339935
54Urinary glycosaminoglycan excretion (HP:0003541)2.69094628
55Mucopolysacchariduria (HP:0008155)2.69094628
56Meningitis (HP:0001287)2.67997119
57Hemoptysis (HP:0002105)2.66789308
58Arterial thrombosis (HP:0004420)2.63667015
59Recurrent pneumonia (HP:0006532)2.61658140
60Abnormality of B cell number (HP:0010975)2.57646004
61Abnormality of the pleura (HP:0002103)2.56905540
62Neurofibrillary tangles (HP:0002185)2.55110163
63Osteomyelitis (HP:0002754)2.54904794
64Metaphyseal irregularity (HP:0003025)2.53916771
65Systemic lupus erythematosus (HP:0002725)2.52886712
66B lymphocytopenia (HP:0010976)2.51050908
67Hypergammaglobulinemia (HP:0010702)2.50482942
68Keratitis (HP:0000491)2.47086164
69Tetraparesis (HP:0002273)2.43756317
70Keratoconjunctivitis sicca (HP:0001097)2.42069738
71Inappropriate behavior (HP:0000719)2.41263731
72Eosinophilia (HP:0001880)2.39658292
73Hematochezia (HP:0002573)2.36474683
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.34428533
75Mesangial abnormality (HP:0001966)2.31739026
76Apathy (HP:0000741)2.29322853
77Abnormality of the pericardium (HP:0001697)2.28861695
78Vertigo (HP:0002321)2.27011961
79Abnormality of iron homeostasis (HP:0011031)2.25609223
80Interstitial pulmonary disease (HP:0006530)2.25245850
81Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.24566495
82Recurrent lower respiratory tract infections (HP:0002783)2.24503017
83Abnormality of liposaccharide metabolism (HP:0010968)2.24450341
84Abnormality of glycosphingolipid metabolism (HP:0004343)2.24450341
85Abnormality of glycolipid metabolism (HP:0010969)2.24450341
86Keratoconjunctivitis (HP:0001096)2.22994672
87Fused cervical vertebrae (HP:0002949)2.22969476
88Disinhibition (HP:0000734)2.22700364
89Combined immunodeficiency (HP:0005387)2.21632430
90Diminished motivation (HP:0000745)2.20263809
91Progressive neurologic deterioration (HP:0002344)2.20133612
92Agnosia (HP:0010524)2.19367138
93Pulmonary artery stenosis (HP:0004415)2.18580752
94Gangrene (HP:0100758)2.17864929
95Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.16638253
96IgA deficiency (HP:0002720)2.14002892
97Chronic otitis media (HP:0000389)2.12700227
98Bone pain (HP:0002653)2.11805317
99Anorexia (HP:0002039)2.10716765
100Episodic fever (HP:0001954)2.10518983
101Memory impairment (HP:0002354)2.10459938
102Pulmonary embolism (HP:0002204)2.07127838
103Abnormality of T cell number (HP:0011839)2.04775567
104Granulocytopenia (HP:0001913)2.04688080
105Acne (HP:0001061)2.04331511
106Arthralgia (HP:0002829)2.03158469
107Albinism (HP:0001022)2.01471408
108Abnormality of the vasculature of the conjunctiva (HP:0008054)1.99786374
109Colitis (HP:0002583)1.99236955
110Epistaxis (HP:0000421)1.98389870
111Abnormality of transition element cation homeostasis (HP:0011030)1.97917122
112Porencephaly (HP:0002132)1.97563643
113Poor head control (HP:0002421)1.96876441
114Agammaglobulinemia (HP:0004432)1.96209874
115IgG deficiency (HP:0004315)1.94174139
116Generalized aminoaciduria (HP:0002909)1.94068102
117Severe combined immunodeficiency (HP:0004430)1.94012629
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93610186
119Complement deficiency (HP:0004431)1.92257370
120Amaurosis fugax (HP:0100576)1.92251393
121Abnormality of eosinophils (HP:0001879)1.88984455
122Autoimmune hemolytic anemia (HP:0001890)1.88552998
123Leukopenia (HP:0001882)1.87735267
124Glomerulopathy (HP:0100820)1.86568855
125Purpura (HP:0000979)1.86566766
126Osteolytic defects of the hand bones (HP:0009699)1.86053034
127Osteolytic defects of the phalanges of the hand (HP:0009771)1.86053034
128Joint swelling (HP:0001386)1.85472682
129Vertebral compression fractures (HP:0002953)1.85472069
130Joint hemorrhage (HP:0005261)1.85326164
131Glomerulonephritis (HP:0000099)1.84368835
132Absent frontal sinuses (HP:0002688)1.83915298
133Pathologic fracture (HP:0002756)1.83728238
134Thyroiditis (HP:0100646)1.83578182
135Submucous cleft hard palate (HP:0000176)1.83101655
136Prolonged bleeding time (HP:0003010)1.83040840
137Skin ulcer (HP:0200042)1.82568836
138Chest pain (HP:0100749)1.82495639
139Flat occiput (HP:0005469)1.82187068
140Cheilitis (HP:0100825)1.81323938
141Neoplasm of head and neck (HP:0012288)1.80803181
142Esophageal neoplasm (HP:0100751)1.80803181
143Myocardial infarction (HP:0001658)1.80745041
144Inflammation of the large intestine (HP:0002037)1.78872848
145Hepatosplenomegaly (HP:0001433)1.77900415
146Restrictive lung disease (HP:0002091)1.76818648
147Abnormality of the endocardium (HP:0004306)1.76068223
148Polyneuropathy (HP:0001271)1.75113499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.53404625
2RIPK44.54234829
3IRAK43.78890168
4TBK13.78604687
5IRAK33.55038801
6TAOK23.46346079
7IKBKE3.30609037
8DDR23.04425220
9TYK23.02482326
10IKBKB2.99484293
11MAP3K132.90951949
12BLK2.75996359
13JAK32.55513464
14TXK2.51308773
15KIT2.47355872
16TAOK12.36946592
17MAP3K112.27201075
18MAP4K12.14001274
19JAK12.04075843
20CHUK1.97699326
21TAOK31.97281441
22PBK1.94505907
23PIM21.85598516
24RIPK11.84771784
25MAP3K31.81692416
26SYK1.45529027
27EIF2AK21.45415674
28RPS6KA41.36285461
29TYRO31.35896694
30CSF1R1.35467986
31HCK1.34072921
32NEK91.33858333
33MAP2K61.33210732
34ACVR1B1.26969660
35ZAP701.25607376
36CDC42BPA1.24455511
37PIM11.18590247
38BMPR21.17996196
39BTK1.16404406
40CSK1.12186135
41LCK1.11254746
42YES11.10349017
43LYN1.09965636
44TEC1.04945673
45SIK21.02540940
46NME21.02140071
47FES0.99321295
48PRPF4B0.97525358
49MST1R0.94051113
50FGR0.94049802
51MST40.92988645
52JAK20.92303650
53STK40.91753267
54TRPM70.85188719
55MAP3K10.80907376
56EPHA30.78033535
57DYRK30.76605864
58SIK30.75375368
59MARK30.74416617
60BMX0.73103333
61ERBB30.72315107
62EPHB10.71532659
63ARAF0.68002610
64LATS20.66665838
65STK100.66646834
66ADRBK20.66472534
67ABL10.65069861
68TLK10.65049510
69TTN0.64792155
70DAPK20.63465147
71PRKCD0.63179837
72TGFBR20.61858375
73EGFR0.61450128
74FGFR30.61414395
75ABL20.60564557
76MATK0.56074643
77CAMKK20.54764164
78MAP3K50.51486887
79GRK70.51188690
80MUSK0.50107326
81MAP2K30.48681190
82CDK60.47301117
83PTK60.46789658
84DAPK30.46745866
85HIPK20.46044094
86ERN10.45682797
87FLT30.44547178
88CDK120.43061571
89PRKCQ0.42185969
90STK30.38709012
91IRAK10.38087003
92MAPK40.37709682
93IRAK20.37600440
94MAPKAPK20.37384821
95NUAK10.36400352
96RPS6KA50.35815821
97INSR0.35640900
98NLK0.34503036
99CAMK1D0.33906349
100PKN10.32556135
101CLK10.31147358
102FYN0.30464990
103RPS6KA60.30409703
104PDK10.30253882
105MOS0.29788320
106SGK10.29248260
107PRKCE0.27806200
108PDPK10.27543874
109PDGFRB0.26925872
110GSK3A0.24727285
111PLK20.24483048
112BMPR1B0.24047256
113ITK0.23041875
114IGF1R0.21386075
115CAMK1G0.20528690
116ATR0.19584597
117DAPK10.19144241
118PDGFRA0.18893023
119FGFR40.15595818
120ERBB40.15266789
121PIK3CA0.14300635
122RPS6KA20.14052846
123SRC0.13139619
124CSNK1A10.13125918
125RPS6KC10.10187437
126RPS6KL10.10187437
127GRK50.08069686
128PRKAA20.08051530
129CSNK1G30.07904728
130FRK0.07878312
131GRK10.07154132
132CSNK1A1L0.06464584
133MAPK30.05594261

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.62088373
2Graft-versus-host disease_Homo sapiens_hsa053323.47386194
3Leishmaniasis_Homo sapiens_hsa051403.17855890
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.98480756
5Toll-like receptor signaling pathway_Homo sapiens_hsa046202.94200902
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.83290421
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.78093416
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.53314471
9Type I diabetes mellitus_Homo sapiens_hsa049402.50200282
10Pertussis_Homo sapiens_hsa051332.40479739
11Legionellosis_Homo sapiens_hsa051342.37889236
12Measles_Homo sapiens_hsa051622.29535833
13Osteoclast differentiation_Homo sapiens_hsa043802.29196054
14Rheumatoid arthritis_Homo sapiens_hsa053232.27113302
15Malaria_Homo sapiens_hsa051442.23908059
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.16322851
17African trypanosomiasis_Homo sapiens_hsa051432.13110754
18Tuberculosis_Homo sapiens_hsa051522.07076708
19Influenza A_Homo sapiens_hsa051642.05413767
20Staphylococcus aureus infection_Homo sapiens_hsa051502.05296389
21TNF signaling pathway_Homo sapiens_hsa046682.03751324
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.96897863
23Asthma_Homo sapiens_hsa053101.92950013
24B cell receptor signaling pathway_Homo sapiens_hsa046621.62605729
25Autoimmune thyroid disease_Homo sapiens_hsa053201.62424135
26Herpes simplex infection_Homo sapiens_hsa051681.57854985
27Toxoplasmosis_Homo sapiens_hsa051451.55483281
28Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.54610725
29Phagosome_Homo sapiens_hsa041451.52809343
30Apoptosis_Homo sapiens_hsa042101.49336593
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.43715741
32Hematopoietic cell lineage_Homo sapiens_hsa046401.40928146
33Salmonella infection_Homo sapiens_hsa051321.39736836
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.38011018
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.35542493
36Chemokine signaling pathway_Homo sapiens_hsa040621.29408504
37Shigellosis_Homo sapiens_hsa051311.24410068
38Lysosome_Homo sapiens_hsa041421.20685330
39Viral myocarditis_Homo sapiens_hsa054161.19994260
40Hepatitis C_Homo sapiens_hsa051601.17177580
41Primary immunodeficiency_Homo sapiens_hsa053401.10052660
42Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.09371315
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08954967
44Hepatitis B_Homo sapiens_hsa051611.04848590
45Antigen processing and presentation_Homo sapiens_hsa046121.02593581
46T cell receptor signaling pathway_Homo sapiens_hsa046600.89013103
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88798270
48Sulfur metabolism_Homo sapiens_hsa009200.88660402
49Amoebiasis_Homo sapiens_hsa051460.86686910
50Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86223585
51Collecting duct acid secretion_Homo sapiens_hsa049660.80245485
52Acute myeloid leukemia_Homo sapiens_hsa052210.76383223
53Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71943032
54Other glycan degradation_Homo sapiens_hsa005110.71253966
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.68991539
56Type II diabetes mellitus_Homo sapiens_hsa049300.64469321
57Bladder cancer_Homo sapiens_hsa052190.64192333
58SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64095420
59Prolactin signaling pathway_Homo sapiens_hsa049170.63964645
60Tryptophan metabolism_Homo sapiens_hsa003800.63207625
61Chronic myeloid leukemia_Homo sapiens_hsa052200.62250363
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61893125
63Glycosaminoglycan degradation_Homo sapiens_hsa005310.59553602
64Epstein-Barr virus infection_Homo sapiens_hsa051690.59225665
65Caffeine metabolism_Homo sapiens_hsa002320.57879018
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.57867613
67Platelet activation_Homo sapiens_hsa046110.53238620
68Small cell lung cancer_Homo sapiens_hsa052220.52680202
69Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52284220
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52263195
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.51849150
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51518273
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46313587
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.43764670
75Pancreatic cancer_Homo sapiens_hsa052120.43109129
76Systemic lupus erythematosus_Homo sapiens_hsa053220.40208994
77Prion diseases_Homo sapiens_hsa050200.39292527
78Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37720341
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37244745
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37193495
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33638770
82Viral carcinogenesis_Homo sapiens_hsa052030.33555215
83Sphingolipid metabolism_Homo sapiens_hsa006000.30106561
84HIF-1 signaling pathway_Homo sapiens_hsa040660.29936470
85Fatty acid biosynthesis_Homo sapiens_hsa000610.29859191
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.28793639
87Carbohydrate digestion and absorption_Homo sapiens_hsa049730.27843612
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27497304
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.27477329
90MicroRNAs in cancer_Homo sapiens_hsa052060.24271423
91HTLV-I infection_Homo sapiens_hsa051660.23815327
92Insulin resistance_Homo sapiens_hsa049310.23157269
93Renin-angiotensin system_Homo sapiens_hsa046140.22865376
94Proteoglycans in cancer_Homo sapiens_hsa052050.22664322
95Notch signaling pathway_Homo sapiens_hsa043300.21718791
96FoxO signaling pathway_Homo sapiens_hsa040680.20778646
97Complement and coagulation cascades_Homo sapiens_hsa046100.20481534
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.18360539
99Folate biosynthesis_Homo sapiens_hsa007900.16258489
100PPAR signaling pathway_Homo sapiens_hsa033200.15899611
101Mineral absorption_Homo sapiens_hsa049780.15600175
102p53 signaling pathway_Homo sapiens_hsa041150.15565560
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.15341604
104VEGF signaling pathway_Homo sapiens_hsa043700.15339837
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15252982
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.14098130
107Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.13735721
108Inositol phosphate metabolism_Homo sapiens_hsa005620.13724278
109Ether lipid metabolism_Homo sapiens_hsa005650.12717127
110MAPK signaling pathway_Homo sapiens_hsa040100.11191208
111Dorso-ventral axis formation_Homo sapiens_hsa043200.10952006
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.10866289
113Prostate cancer_Homo sapiens_hsa052150.09411183
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.09012058
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.08073930
116Fructose and mannose metabolism_Homo sapiens_hsa000510.07874995
117Ovarian steroidogenesis_Homo sapiens_hsa049130.03667713
118Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.0143911
119Galactose metabolism_Homo sapiens_hsa00052-0.0045788
120Steroid biosynthesis_Homo sapiens_hsa00100-0.0037762

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