TNIK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Germinal center kinases (GCKs), such as TNIK, are characterized by an N-terminal kinase domain and a C-terminal GCK domain that serves a regulatory function (Fu et al., 1999 [PubMed 10521462]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.43147036
2locomotory exploration behavior (GO:0035641)5.30287189
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.28895504
4vocalization behavior (GO:0071625)4.97184534
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.87941412
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.73100815
7neuron cell-cell adhesion (GO:0007158)4.71814083
8synaptic vesicle maturation (GO:0016188)4.66245403
9synaptic vesicle exocytosis (GO:0016079)4.58395224
10regulation of glutamate receptor signaling pathway (GO:1900449)4.51244005
11protein localization to synapse (GO:0035418)4.48637600
12pyrimidine nucleobase catabolic process (GO:0006208)4.47390635
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.37427505
14glutamate receptor signaling pathway (GO:0007215)4.34186543
15neuronal action potential propagation (GO:0019227)4.26245619
16nerve growth factor signaling pathway (GO:0038180)4.22997836
17cytoplasmic mRNA processing body assembly (GO:0033962)4.18965748
18regulation of synaptic vesicle exocytosis (GO:2000300)4.18056003
19synaptic transmission, glutamatergic (GO:0035249)4.16936843
20glutamate secretion (GO:0014047)4.16569161
21neurotransmitter-gated ion channel clustering (GO:0072578)4.11387355
22regulation of NFAT protein import into nucleus (GO:0051532)4.09240193
23exploration behavior (GO:0035640)4.04258357
24establishment of nucleus localization (GO:0040023)4.03630569
25presynaptic membrane assembly (GO:0097105)4.02949324
26gamma-aminobutyric acid transport (GO:0015812)4.02406358
27establishment of mitochondrion localization (GO:0051654)4.00249580
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.97264947
29dendritic spine morphogenesis (GO:0060997)3.97096755
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.96934249
31transmission of nerve impulse (GO:0019226)3.94388858
32regulation of neuronal synaptic plasticity (GO:0048168)3.92355057
33neuron-neuron synaptic transmission (GO:0007270)3.91458811
34synaptic vesicle docking involved in exocytosis (GO:0016081)3.89303004
35layer formation in cerebral cortex (GO:0021819)3.88544017
36membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.83001105
37long-term memory (GO:0007616)3.77821174
38neurotransmitter secretion (GO:0007269)3.73191028
39regulation of synaptic vesicle transport (GO:1902803)3.71285099
40regulation of synapse structural plasticity (GO:0051823)3.68995410
41presynaptic membrane organization (GO:0097090)3.68955179
42positive regulation of membrane potential (GO:0045838)3.64599527
43mitochondrion transport along microtubule (GO:0047497)3.64329597
44establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.64329597
45G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.63334346
46regulation of excitatory postsynaptic membrane potential (GO:0060079)3.62988539
47neuron recognition (GO:0008038)3.62272050
48postsynaptic membrane organization (GO:0001941)3.58939784
49nucleobase catabolic process (GO:0046113)3.56030186
50L-amino acid import (GO:0043092)3.53845641
51dendrite morphogenesis (GO:0048813)3.51035750
52neuronal ion channel clustering (GO:0045161)3.49516553
53regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47976327
54cerebellar granule cell differentiation (GO:0021707)3.47533140
55regulation of postsynaptic membrane potential (GO:0060078)3.45907618
56cellular potassium ion homeostasis (GO:0030007)3.41167895
57axonal fasciculation (GO:0007413)3.38948908
58gamma-aminobutyric acid signaling pathway (GO:0007214)3.36659027
59positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.36555705
60regulation of dendritic spine morphogenesis (GO:0061001)3.36348775
61auditory behavior (GO:0031223)3.32758195
62negative regulation of synaptic transmission, GABAergic (GO:0032229)3.31310162
63regulation of synaptic transmission, glutamatergic (GO:0051966)3.31143665
64cerebral cortex radially oriented cell migration (GO:0021799)3.30228173
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.29713428
66regulation of synaptic plasticity (GO:0048167)3.23720143
67cerebellar Purkinje cell differentiation (GO:0021702)3.20991837
68negative regulation of neurotransmitter secretion (GO:0046929)3.20663270
69long-term synaptic potentiation (GO:0060291)3.20384066
70response to auditory stimulus (GO:0010996)3.19136870
71proline transport (GO:0015824)3.16470612
72positive regulation of synapse maturation (GO:0090129)3.16091820
73negative regulation of histone methylation (GO:0031061)3.12526872
74negative regulation of neurotransmitter transport (GO:0051589)3.11680114
75positive regulation of synaptic transmission, GABAergic (GO:0032230)3.11264869
76neurotransmitter transport (GO:0006836)3.10991753
77mating behavior (GO:0007617)3.10453021
78response to histamine (GO:0034776)3.09696035
79regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.09115239
80synapse assembly (GO:0007416)3.05941757
81membrane hyperpolarization (GO:0060081)3.04573226
82synaptic vesicle endocytosis (GO:0048488)3.03376504
83regulation of neurotransmitter secretion (GO:0046928)3.03328316
84positive regulation of dendritic spine development (GO:0060999)3.02392654
85neuromuscular process controlling balance (GO:0050885)3.02199999
86membrane depolarization (GO:0051899)3.01847995
87regulation of dendritic spine development (GO:0060998)2.98629221
88learning (GO:0007612)2.97888592
89central nervous system projection neuron axonogenesis (GO:0021952)2.97538776
90adult walking behavior (GO:0007628)2.97023831
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.96728469
92suckling behavior (GO:0001967)2.96179581
93prepulse inhibition (GO:0060134)2.95727607
94membrane depolarization during action potential (GO:0086010)2.95558199
95regulation of vesicle fusion (GO:0031338)2.95095220
96amino acid import (GO:0043090)2.94012801
97sodium ion export (GO:0071436)2.93427619
98cellular response to nerve growth factor stimulus (GO:1990090)2.91695290
99response to nerve growth factor (GO:1990089)2.91695290
100cell migration in hindbrain (GO:0021535)2.91249964
101nucleus localization (GO:0051647)2.91182725
102synapse organization (GO:0050808)2.88983064
103behavioral defense response (GO:0002209)2.88129358
104behavioral fear response (GO:0001662)2.88129358
105negative regulation of translation, ncRNA-mediated (GO:0040033)2.86893299
106regulation of translation, ncRNA-mediated (GO:0045974)2.86893299
107negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.86893299
108startle response (GO:0001964)2.86556525
109innervation (GO:0060384)2.86456992
110regulation of neurotransmitter levels (GO:0001505)2.86401464
111positive regulation of neurotransmitter secretion (GO:0001956)2.85927861
112cell communication by electrical coupling (GO:0010644)2.85478833
113regulation of voltage-gated calcium channel activity (GO:1901385)2.84035388
114adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.83344423
115regulation of cAMP-dependent protein kinase activity (GO:2000479)2.82713573
116regulation of neurotransmitter transport (GO:0051588)2.80985632
117organelle transport along microtubule (GO:0072384)2.80356083
118mechanosensory behavior (GO:0007638)2.80282532
119dendritic spine organization (GO:0097061)2.80000998
120central nervous system neuron axonogenesis (GO:0021955)2.78739248
121cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.78308868
122histone H3-K9 demethylation (GO:0033169)2.77407866
123positive regulation of synapse assembly (GO:0051965)2.76482441
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.76315830
125regulation of synaptic transmission, GABAergic (GO:0032228)2.76200329
126dendrite development (GO:0016358)2.76013713
127positive regulation of synaptic transmission (GO:0050806)2.75545335
128regulation of DNA methylation (GO:0044030)2.75213839
129regulation of synaptic transmission (GO:0050804)2.73631473
130membrane assembly (GO:0071709)2.69418836
131glucocorticoid receptor signaling pathway (GO:0042921)2.67219692
132atrial cardiac muscle cell action potential (GO:0086014)2.64166331
133axon extension (GO:0048675)2.61030067
134regulation of axon guidance (GO:1902667)2.56986414
135embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56201088
136negative regulation of dendrite development (GO:2000171)2.55214415
137apical protein localization (GO:0045176)2.51831013
138centrosome localization (GO:0051642)2.51813028
139heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.51298728
140negative regulation of axonogenesis (GO:0050771)2.45143136
141regulation of axon extension involved in axon guidance (GO:0048841)2.44803854
142astrocyte development (GO:0014002)2.43444916
143sarcoplasmic reticulum calcium ion transport (GO:0070296)2.41960290
144long-chain fatty acid biosynthetic process (GO:0042759)2.41897278
145peptidyl-threonine phosphorylation (GO:0018107)2.40070146
146regulation of Rac protein signal transduction (GO:0035020)2.39893070
147axon cargo transport (GO:0008088)2.39167720
148regulation of histone H3-K9 methylation (GO:0051570)2.36840565
149positive regulation of microtubule polymerization (GO:0031116)2.36322494

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.46413895
2GBX2_23144817_ChIP-Seq_PC3_Human3.87237964
3RBPJ_22232070_ChIP-Seq_NCS_Mouse2.98545248
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95369242
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95350678
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.88884563
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.52763012
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.52763012
9DROSHA_22980978_ChIP-Seq_HELA_Human2.51982356
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.47033517
11SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.44717688
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43559255
13REST_21632747_ChIP-Seq_MESCs_Mouse2.41998832
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.40434529
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36084522
16MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34764506
17* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.29686491
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.25382568
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.18650837
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.13892689
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.12087210
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.11507392
23AR_21572438_ChIP-Seq_LNCaP_Human2.08568647
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98652295
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.90137994
26REST_18959480_ChIP-ChIP_MESCs_Mouse1.86525702
27CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81499327
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.78650462
29* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.78360650
30TAF15_26573619_Chip-Seq_HEK293_Human1.74061061
31IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70791807
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66666458
33* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66466404
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.65521023
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64815800
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.61855134
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59210537
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52578620
39RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.52487991
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.49391744
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.49281755
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.48487372
43WT1_19549856_ChIP-ChIP_CCG9911_Human1.48396476
44P300_19829295_ChIP-Seq_ESCs_Human1.48100148
45CBX2_27304074_Chip-Seq_ESCs_Mouse1.48047603
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46788791
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.46430201
48KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.41748961
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39730195
50SMAD_19615063_ChIP-ChIP_OVARY_Human1.38807842
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38404053
52TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37692775
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36874899
54LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.36634964
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36599690
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36367396
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35251969
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.34959736
59HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34894522
60* STAT3_23295773_ChIP-Seq_U87_Human1.34416506
61EWS_26573619_Chip-Seq_HEK293_Human1.34179067
62ZNF274_21170338_ChIP-Seq_K562_Hela1.32725814
63* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32437119
64SOX2_21211035_ChIP-Seq_LN229_Gbm1.31797624
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.31563887
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.29891584
67SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.28921415
68VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.28852804
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28787481
70AR_25329375_ChIP-Seq_VCAP_Human1.27461238
71SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25898203
72* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24864121
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24659860
74TOP2B_26459242_ChIP-Seq_MCF-7_Human1.23402527
75* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23063098
76* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21491627
77* AR_19668381_ChIP-Seq_PC3_Human1.21275837
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.20693247
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20382284
80* TCF4_23295773_ChIP-Seq_U87_Human1.19824803
81P53_22127205_ChIP-Seq_FIBROBLAST_Human1.19698168
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18657955
83SOX9_26525672_Chip-Seq_HEART_Mouse1.17858280
84CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.17718904
85TP53_16413492_ChIP-PET_HCT116_Human1.17223634
86GATA1_26923725_Chip-Seq_HPCs_Mouse1.16975079
87ARNT_22903824_ChIP-Seq_MCF-7_Human1.16703748
88FUS_26573619_Chip-Seq_HEK293_Human1.16053615
89* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15444967
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15371477
91KDM2B_26808549_Chip-Seq_REH_Human1.14843461
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.13334629
93* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12835117
94RNF2_27304074_Chip-Seq_NSC_Mouse1.12580518
95CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11493801
96YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10066554
97AHR_22903824_ChIP-Seq_MCF-7_Human1.09438223
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09250016
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.09250016
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07723730
101* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07312710
102TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07236335
103RUNX2_22187159_ChIP-Seq_PCA_Human1.06787966
104RING1B_27294783_Chip-Seq_NPCs_Mouse1.06027607
105TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04750432
106ER_23166858_ChIP-Seq_MCF-7_Human1.04713664
107* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04339714
108FLI1_27457419_Chip-Seq_LIVER_Mouse1.04148605
109IGF1R_20145208_ChIP-Seq_DFB_Human1.03978448
110CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02840257
111* E2F1_18555785_Chip-Seq_ESCs_Mouse1.01596311
112* PRDM14_20953172_ChIP-Seq_ESCs_Human1.00704576
113UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.00596500
114* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99566118
115* NANOG_18555785_Chip-Seq_ESCs_Mouse0.99123099
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99095686
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98574391
118* SMAD4_21741376_ChIP-Seq_HESCs_Human0.93877609
119TP53_18474530_ChIP-ChIP_U2OS_Human0.93449768
120* SMAD3_21741376_ChIP-Seq_ESCs_Human0.93387249
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91541120
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.89528791
123RXR_22108803_ChIP-Seq_LS180_Human0.89009584
124DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88553310
125* SMAD3_21741376_ChIP-Seq_HESCs_Human0.88422113
126BCAT_22108803_ChIP-Seq_LS180_Human0.87693115

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.97392613
2MP0003880_abnormal_central_pattern4.67785154
3MP0004270_analgesia3.95477766
4MP0003635_abnormal_synaptic_transmissio3.94014635
5MP0009745_abnormal_behavioral_response3.32294456
6MP0002063_abnormal_learning/memory/cond3.11068619
7MP0009046_muscle_twitch3.06444636
8MP0002064_seizures3.05932647
9MP0005423_abnormal_somatic_nervous2.92478366
10MP0002822_catalepsy2.90339007
11MP0001486_abnormal_startle_reflex2.88475006
12MP0002572_abnormal_emotion/affect_behav2.74788238
13MP0001968_abnormal_touch/_nociception2.70789160
14MP0002734_abnormal_mechanical_nocicepti2.62478267
15MP0002272_abnormal_nervous_system2.60126860
16MP0001440_abnormal_grooming_behavior2.22596024
17MP0000778_abnormal_nervous_system2.16868381
18MP0003890_abnormal_embryonic-extraembry2.16591897
19MP0001501_abnormal_sleep_pattern2.10950103
20MP0002735_abnormal_chemical_nociception2.09544814
21MP0002736_abnormal_nociception_after2.03885998
22MP0002067_abnormal_sensory_capabilities2.03802486
23MP0008057_abnormal_DNA_replication2.00415740
24MP0008569_lethality_at_weaning1.95596135
25MP0009780_abnormal_chondrocyte_physiolo1.91055745
26MP0002733_abnormal_thermal_nociception1.89805504
27MP0003121_genomic_imprinting1.87408670
28MP0004885_abnormal_endolymph1.84000043
29MP0002557_abnormal_social/conspecific_i1.81122998
30MP0001970_abnormal_pain_threshold1.80791839
31MP0005646_abnormal_pituitary_gland1.78834020
32MP0004924_abnormal_behavior1.78296255
33MP0005386_behavior/neurological_phenoty1.78296255
34MP0002184_abnormal_innervation1.72821682
35MP0003329_amyloid_beta_deposits1.63907168
36MP0001984_abnormal_olfaction1.61696684
37MP0000955_abnormal_spinal_cord1.60075015
38MP0003787_abnormal_imprinting1.60059407
39MP0008877_abnormal_DNA_methylation1.57545763
40MP0004811_abnormal_neuron_physiology1.55659972
41MP0001502_abnormal_circadian_rhythm1.54029660
42MP0005409_darkened_coat_color1.52862978
43MP0002882_abnormal_neuron_morphology1.50613695
44MP0004142_abnormal_muscle_tone1.45974915
45MP0001529_abnormal_vocalization1.45111872
46MP0002877_abnormal_melanocyte_morpholog1.43834071
47MP0004742_abnormal_vestibular_system1.43489079
48MP0002066_abnormal_motor_capabilities/c1.41248540
49MP0004858_abnormal_nervous_system1.36686015
50MP0005645_abnormal_hypothalamus_physiol1.36239546
51MP0006276_abnormal_autonomic_nervous1.33377771
52MP0001188_hyperpigmentation1.32742388
53MP0003633_abnormal_nervous_system1.30553644
54MP0000920_abnormal_myelination1.29275760
55MP0003690_abnormal_glial_cell1.28428643
56MP0003879_abnormal_hair_cell1.24521389
57MP0001905_abnormal_dopamine_level1.21534111
58MP0001485_abnormal_pinna_reflex1.21143650
59MP0003183_abnormal_peptide_metabolism1.20298287
60MP0005551_abnormal_eye_electrophysiolog1.17401630
61MP0002152_abnormal_brain_morphology1.15853871
62MP0004145_abnormal_muscle_electrophysio1.14277335
63MP0003631_nervous_system_phenotype1.13945517
64MP0002909_abnormal_adrenal_gland1.13905902
65MP0005187_abnormal_penis_morphology1.12655849
66MP0002229_neurodegeneration1.10453314
67MP0000751_myopathy1.06914779
68MP0003634_abnormal_glial_cell1.06850924
69MP0000569_abnormal_digit_pigmentation1.02816948
70MP0004510_myositis1.01899565
71MP0001963_abnormal_hearing_physiology0.98759494
72MP0003119_abnormal_digestive_system0.97183927
73MP0004215_abnormal_myocardial_fiber0.93780939
74MP0005171_absent_coat_pigmentation0.93394541
75MP0003632_abnormal_nervous_system0.93073888
76MP0000631_abnormal_neuroendocrine_gland0.92526674
77MP0001293_anophthalmia0.92358334
78MP0002081_perinatal_lethality0.91154176
79MP0002752_abnormal_somatic_nervous0.89978666
80MP0002069_abnormal_eating/drinking_beha0.88504429
81MP0003303_peritoneal_inflammation0.87065366
82MP0003137_abnormal_impulse_conducting0.86855112
83MP0001177_atelectasis0.84947352
84MP0004085_abnormal_heartbeat0.83378233
85MP0001299_abnormal_eye_distance/0.81150176
86MP0009703_decreased_birth_body0.81012795
87MP0008874_decreased_physiological_sensi0.80629252
88MP0003122_maternal_imprinting0.80588083
89MP0009672_abnormal_birth_weight0.80585103
90MP0004130_abnormal_muscle_cell0.80559630
91MP0006072_abnormal_retinal_apoptosis0.79045570
92MP0003136_yellow_coat_color0.76121432
93MP0008770_decreased_survivor_rate0.75295625
94MP0003868_abnormal_feces_composition0.74041651
95MP0000428_abnormal_craniofacial_morphol0.72513939
96MP0004084_abnormal_cardiac_muscle0.70729376
97MP0000026_abnormal_inner_ear0.70154782
98MP0008961_abnormal_basal_metabolism0.70068963
99MP0005248_abnormal_Harderian_gland0.70043405
100MP0003935_abnormal_craniofacial_develop0.69252024
101MP0005394_taste/olfaction_phenotype0.68452468
102MP0005499_abnormal_olfactory_system0.68452468
103MP0003567_abnormal_fetal_cardiomyocyte0.68133936
104MP0008872_abnormal_physiological_respon0.67824346
105MP0010386_abnormal_urinary_bladder0.64507138
106MP0002090_abnormal_vision0.64273208
107MP0003861_abnormal_nervous_system0.63884134
108MP0003045_fibrosis0.63269108
109MP0002009_preneoplasia0.63054832
110MP0005620_abnormal_muscle_contractility0.62902447
111MP0003123_paternal_imprinting0.61801805
112MP0005253_abnormal_eye_physiology0.59922336
113MP0003091_abnormal_cell_migration0.59803681
114MP0001943_abnormal_respiration0.59155689
115MP0002638_abnormal_pupillary_reflex0.59143499
116MP0003283_abnormal_digestive_organ0.58840733
117MP0010769_abnormal_survival0.58174204
118MP0000604_amyloidosis0.57614088
119MP0010770_preweaning_lethality0.56368266
120MP0002082_postnatal_lethality0.56368266
121MP0005535_abnormal_body_temperature0.56260416
122MP0001664_abnormal_digestion0.56047305
123MP0004484_altered_response_of0.54795678
124MP0010768_mortality/aging0.54668980
125MP0004043_abnormal_pH_regulation0.53363403
126MP0002102_abnormal_ear_morphology0.51440427

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.24754482
2Myokymia (HP:0002411)5.58747198
3Focal seizures (HP:0007359)5.43213938
4Epileptic encephalopathy (HP:0200134)4.78270660
5Atonic seizures (HP:0010819)4.41340478
6Febrile seizures (HP:0002373)4.37167539
7Progressive cerebellar ataxia (HP:0002073)4.21545027
8Visual hallucinations (HP:0002367)4.04425185
9Cortical dysplasia (HP:0002539)3.84139075
10Action tremor (HP:0002345)3.72782954
11Absence seizures (HP:0002121)3.69725864
12Broad-based gait (HP:0002136)3.65670002
13Dialeptic seizures (HP:0011146)3.58852709
14Gaze-evoked nystagmus (HP:0000640)3.52830905
15Supranuclear gaze palsy (HP:0000605)3.52808052
16Hyperventilation (HP:0002883)3.44900868
17Papillary thyroid carcinoma (HP:0002895)3.43937475
18Generalized tonic-clonic seizures (HP:0002069)3.40599618
19Dysmetria (HP:0001310)3.20890941
20Dysdiadochokinesis (HP:0002075)3.20155333
21Impaired vibration sensation in the lower limbs (HP:0002166)3.13469836
22Ankle clonus (HP:0011448)3.13172897
23Urinary bladder sphincter dysfunction (HP:0002839)3.03160030
24Truncal ataxia (HP:0002078)2.99651171
25Scanning speech (HP:0002168)2.94440664
26Poor eye contact (HP:0000817)2.93506408
27Genetic anticipation (HP:0003743)2.92005774
28Hemiparesis (HP:0001269)2.90202441
29Abnormality of the corticospinal tract (HP:0002492)2.86986089
30Neurofibrillary tangles (HP:0002185)2.82287011
31Spastic gait (HP:0002064)2.81192862
32Excessive salivation (HP:0003781)2.79156269
33Drooling (HP:0002307)2.79156269
34Abnormal social behavior (HP:0012433)2.72145611
35Impaired social interactions (HP:0000735)2.72145611
36Depression (HP:0000716)2.71166826
37Diplopia (HP:0000651)2.68481266
38Abnormality of binocular vision (HP:0011514)2.68481266
39Abnormal eating behavior (HP:0100738)2.67049989
40Megalencephaly (HP:0001355)2.65079133
41Postural instability (HP:0002172)2.60974540
42Hepatoblastoma (HP:0002884)2.60227332
43Inappropriate behavior (HP:0000719)2.59077212
44Aplasia involving bones of the upper limbs (HP:0009823)2.53128688
45Aplasia of the phalanges of the hand (HP:0009802)2.53128688
46Aplasia involving bones of the extremities (HP:0009825)2.53128688
47Intention tremor (HP:0002080)2.52209650
48Abnormality of the ischium (HP:0003174)2.52086314
49Anxiety (HP:0000739)2.50555654
50Urinary urgency (HP:0000012)2.49432158
51Stereotypic behavior (HP:0000733)2.48098868
52Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.46083473
53Degeneration of the lateral corticospinal tracts (HP:0002314)2.46083473
54Progressive inability to walk (HP:0002505)2.42254842
55Cerebral inclusion bodies (HP:0100314)2.41854112
56Fetal akinesia sequence (HP:0001989)2.40741914
57Amblyopia (HP:0000646)2.38355701
58Akinesia (HP:0002304)2.33828862
59Volvulus (HP:0002580)2.33499165
60Hammertoe (HP:0001765)2.33312723
61Insidious onset (HP:0003587)2.31911025
62Termporal pattern (HP:0011008)2.31911025
63Absent speech (HP:0001344)2.31886215
64Lower limb muscle weakness (HP:0007340)2.28252096
65Exotropia (HP:0000577)2.28071536
66Impaired smooth pursuit (HP:0007772)2.27705867
67Hemiplegia (HP:0002301)2.26971947
68Mutism (HP:0002300)2.26146964
69Abnormality of the left ventricular outflow tract (HP:0011103)2.21192751
70Subaortic stenosis (HP:0001682)2.21192751
71Blue irides (HP:0000635)2.21076445
72Impaired vibratory sensation (HP:0002495)2.20724879
73Abnormality of the labia minora (HP:0012880)2.20099246
74Oligodactyly (hands) (HP:0001180)2.20021379
75Epileptiform EEG discharges (HP:0011182)2.19036178
76Difficulty running (HP:0009046)2.18311241
77Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.15872572
78Decreased motor nerve conduction velocity (HP:0003431)2.14530792
79Neuroendocrine neoplasm (HP:0100634)2.14212660
80Vertebral arch anomaly (HP:0008438)2.11156564
81EEG with generalized epileptiform discharges (HP:0011198)2.07706664
82Thyroid carcinoma (HP:0002890)2.07263254
83Transitional cell carcinoma of the bladder (HP:0006740)2.06507264
84Amyotrophic lateral sclerosis (HP:0007354)2.06329216
85Abnormality of the lower motor neuron (HP:0002366)2.05904715
86Obsessive-compulsive behavior (HP:0000722)2.05874561
87Abnormality of ocular smooth pursuit (HP:0000617)2.05299832
88Pheochromocytoma (HP:0002666)2.05152198
89Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.03957399
90Dysmetric saccades (HP:0000641)2.03674522
91Thickened helices (HP:0000391)2.03496698
92Polyphagia (HP:0002591)1.99760729
93Papilledema (HP:0001085)1.99476763
94Generalized myoclonic seizures (HP:0002123)1.98391402
95Cerebral hemorrhage (HP:0001342)1.98010761
96Inability to walk (HP:0002540)1.97750588
97Torticollis (HP:0000473)1.96267870
98Bradykinesia (HP:0002067)1.95860730
99Abnormality of salivation (HP:0100755)1.95669407
100Hypsarrhythmia (HP:0002521)1.95129353
101Status epilepticus (HP:0002133)1.94139745
102Mild short stature (HP:0003502)1.93205589
103Prolonged QT interval (HP:0001657)1.92416772
104Protruding tongue (HP:0010808)1.92190689
105Cubitus valgus (HP:0002967)1.91079267
106Long clavicles (HP:0000890)1.90448566
107Bladder neoplasm (HP:0009725)1.85999153
108Bladder carcinoma (HP:0002862)1.85999153
109Widely spaced teeth (HP:0000687)1.85749836
110Abnormality of saccadic eye movements (HP:0000570)1.85342207
111Morphological abnormality of the middle ear (HP:0008609)1.84617677
112Aplasia/Hypoplasia of the sternum (HP:0006714)1.82790563
113Leiomyosarcoma (HP:0100243)1.82620437
114Uterine leiomyosarcoma (HP:0002891)1.82620437
115Steppage gait (HP:0003376)1.82287948
116Malignant gastrointestinal tract tumors (HP:0006749)1.80921473
117Gastrointestinal carcinoma (HP:0002672)1.80921473
118Cystic hygroma (HP:0000476)1.80345211
119Abnormal EKG (HP:0003115)1.80310786
120Truncal obesity (HP:0001956)1.80165262
121Peripheral hypomyelination (HP:0007182)1.79000344
122Cutaneous finger syndactyly (HP:0010554)1.77918125
123Limb dystonia (HP:0002451)1.77837236
124Bundle branch block (HP:0011710)1.77784057
125Gait ataxia (HP:0002066)1.77675834
126Sacral dimple (HP:0000960)1.77070485
127Open mouth (HP:0000194)1.75644973
128Agitation (HP:0000713)1.74785350
129Heterotopia (HP:0002282)1.74667747
130Clumsiness (HP:0002312)1.74524568
131Focal dystonia (HP:0004373)1.73415948
132Clonus (HP:0002169)1.73362806
133Exercise-induced muscle cramps (HP:0003710)1.73297690
134Absent/shortened dynein arms (HP:0200106)1.73286573
135Dynein arm defect of respiratory motile cilia (HP:0012255)1.73286573
136Retinal dysplasia (HP:0007973)1.73203595
137Incomplete penetrance (HP:0003829)1.72707942
138Aqueductal stenosis (HP:0002410)1.71733990
139Abnormal hair whorl (HP:0010721)1.71576401
140Neonatal short-limb short stature (HP:0008921)1.71278002
141Deeply set eye (HP:0000490)1.70949226
142Specific learning disability (HP:0001328)1.70688786
143Lower limb amyotrophy (HP:0007210)1.70421070
144Abnormality of chromosome segregation (HP:0002916)1.70014482
145Abnormal pancreas size (HP:0012094)1.69757648
146Gait imbalance (HP:0002141)1.69663647
147Disinhibition (HP:0000734)1.69440773
148Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.69113086
149Onion bulb formation (HP:0003383)1.66158727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.53482462
2EPHA44.26350883
3MARK13.47530823
4MAP3K92.87321089
5MAP3K42.74268547
6NTRK22.48857422
7MAP2K72.48534393
8CASK2.35416805
9BRD42.27256918
10MINK12.23455230
11PAK62.12050862
12CDK122.02766446
13MAPK131.91280002
14PRPF4B1.89661606
15DAPK21.88684634
16MAP3K101.66212246
17NTRK11.56085003
18CDK51.54953560
19MAP2K41.54206969
20KSR11.53908159
21PHKG21.47277088
22PHKG11.47277088
23CDK191.46871940
24PRKD31.45853983
25KSR21.44935885
26TYRO31.44407860
27YES11.42978068
28OXSR11.39722249
29MAP3K121.36875419
30RIPK41.36128832
31FES1.35288747
32CAMKK11.31738490
33SIK21.31050565
34MAP3K131.29521344
35WNK31.27395859
36PRKCG1.24254378
37PNCK1.22152086
38MKNK21.20746190
39UHMK11.17429924
40STK391.16927415
41MKNK11.13374508
42DYRK21.11683440
43MARK21.09368656
44OBSCN1.09176009
45STK381.06929643
46ACVR1B1.04988969
47NEK61.04176281
48CAMK2A1.04133823
49DAPK11.00324932
50PLK21.00111315
51SGK2230.99664289
52SGK4940.99664289
53STK240.96247036
54MAP3K20.93706921
55STK110.93477011
56LATS20.92267219
57EPHA30.90584397
58CAMK2B0.89914492
59PAK30.89684879
60CAMK10.87384990
61CAMKK20.87360043
62SGK20.86370668
63GRK50.86117715
64MUSK0.85786652
65CSNK1G20.85173408
66CDK180.82702630
67SGK10.82698497
68DYRK1A0.81465184
69CDK150.81242400
70TAOK10.80960445
71PRKCH0.80821573
72FGFR20.80344371
73WNK10.77127867
74MAP3K60.76656522
75CDK140.76523077
76TAF10.76183542
77RET0.76063233
78PKN10.71653711
79SGK30.71272579
80CDK11A0.71268948
81TNK20.70311052
82CAMK1G0.69035416
83MOS0.68882773
84MAP3K70.66516338
85PRKCE0.65512662
86LMTK20.64837217
87ICK0.64183001
88TRIM280.63963748
89BCR0.62955484
90FGR0.62482403
91RAF10.61445765
92FYN0.61324534
93ERBB30.61322984
94CAMK2D0.60575111
95DMPK0.58531229
96JAK10.57334712
97PTK2B0.57160436
98PDPK10.56297376
99BMPR20.54218608
100PDK10.53605644
101PDGFRB0.53438767
102CAMK1D0.53019591
103CDC42BPA0.52948027
104RPS6KA30.52861338
105* TNIK0.52194703
106CSNK1E0.52024745
107ROCK20.50920558
108ALK0.48660901
109BMPR1B0.48547256
110NLK0.47296153
111INSRR0.46763472
112MAP3K10.46499717
113MAPK100.46073082
114CAMK2G0.44605690
115PKN20.44528166
116CDC70.44446560
117GSK3B0.44111555
118CSNK1A1L0.44015508
119PINK10.43888210
120PRKCZ0.43701512
121PRKG10.43194338
122SIK30.42457356
123RPS6KA40.42104635
124CDK30.42016063
125ARAF0.41818210
126MAPK120.41443164
127NEK20.40415916
128STK30.40162293
129PRKCB0.40009471
130PRKCQ0.38085945
131RIPK10.37429379
132PDGFRA0.35826337
133PRKDC0.33332545
134CSNK1D0.33170245
135MAPK80.31478726
136RPS6KB10.29367098

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.71588732
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.77536781
3Glutamatergic synapse_Homo sapiens_hsa047242.70057606
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.67113718
5Circadian entrainment_Homo sapiens_hsa047132.66574309
6GABAergic synapse_Homo sapiens_hsa047272.64892733
7Synaptic vesicle cycle_Homo sapiens_hsa047212.60616550
8Olfactory transduction_Homo sapiens_hsa047402.55604152
9Morphine addiction_Homo sapiens_hsa050322.54852972
10Long-term potentiation_Homo sapiens_hsa047202.51363059
11Amphetamine addiction_Homo sapiens_hsa050312.24025417
12Salivary secretion_Homo sapiens_hsa049702.09069392
13Dopaminergic synapse_Homo sapiens_hsa047282.01332228
14Insulin secretion_Homo sapiens_hsa049111.90390715
15Cholinergic synapse_Homo sapiens_hsa047251.87893779
16Gastric acid secretion_Homo sapiens_hsa049711.80327797
17Serotonergic synapse_Homo sapiens_hsa047261.76635073
18Long-term depression_Homo sapiens_hsa047301.75412175
19Taste transduction_Homo sapiens_hsa047421.74992758
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68479885
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.68278224
22Renin secretion_Homo sapiens_hsa049241.66965936
23Calcium signaling pathway_Homo sapiens_hsa040201.63391176
24Oxytocin signaling pathway_Homo sapiens_hsa049211.61781827
25Cocaine addiction_Homo sapiens_hsa050301.61265766
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56146764
27Axon guidance_Homo sapiens_hsa043601.50879262
28Colorectal cancer_Homo sapiens_hsa052101.45040204
29GnRH signaling pathway_Homo sapiens_hsa049121.39022383
30cAMP signaling pathway_Homo sapiens_hsa040241.35301910
31Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.28986878
32Adherens junction_Homo sapiens_hsa045201.28646909
33Gap junction_Homo sapiens_hsa045401.25819031
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24720749
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21680545
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20198382
37Type II diabetes mellitus_Homo sapiens_hsa049301.20017213
38ErbB signaling pathway_Homo sapiens_hsa040121.17824838
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13738779
40Dorso-ventral axis formation_Homo sapiens_hsa043201.08932665
41Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08039241
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07789738
43Prolactin signaling pathway_Homo sapiens_hsa049171.03808841
44Estrogen signaling pathway_Homo sapiens_hsa049151.02222784
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01664740
46Phospholipase D signaling pathway_Homo sapiens_hsa040721.01050834
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.00494898
48Collecting duct acid secretion_Homo sapiens_hsa049661.00432751
49B cell receptor signaling pathway_Homo sapiens_hsa046620.99798547
50Glioma_Homo sapiens_hsa052140.98922520
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.98758508
52Melanogenesis_Homo sapiens_hsa049160.97386698
53Tight junction_Homo sapiens_hsa045300.97215152
54Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96221991
55Platelet activation_Homo sapiens_hsa046110.94543368
56Cardiac muscle contraction_Homo sapiens_hsa042600.94190776
57Dilated cardiomyopathy_Homo sapiens_hsa054140.92637552
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92272797
59Phototransduction_Homo sapiens_hsa047440.91319228
60Pancreatic secretion_Homo sapiens_hsa049720.90439289
61Choline metabolism in cancer_Homo sapiens_hsa052310.90338543
62Circadian rhythm_Homo sapiens_hsa047100.84661174
63Chronic myeloid leukemia_Homo sapiens_hsa052200.82438258
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81237122
65MAPK signaling pathway_Homo sapiens_hsa040100.80352149
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76278546
67MicroRNAs in cancer_Homo sapiens_hsa052060.75333792
68Ras signaling pathway_Homo sapiens_hsa040140.74929223
69mRNA surveillance pathway_Homo sapiens_hsa030150.74472406
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73489790
71Pancreatic cancer_Homo sapiens_hsa052120.72933717
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70396196
73FoxO signaling pathway_Homo sapiens_hsa040680.67858935
74Thyroid hormone synthesis_Homo sapiens_hsa049180.66894129
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65545762
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65069914
77Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64934216
78Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.64797710
79Rap1 signaling pathway_Homo sapiens_hsa040150.64114767
80Prostate cancer_Homo sapiens_hsa052150.63324877
81Sphingolipid signaling pathway_Homo sapiens_hsa040710.62868756
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.62793356
83Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61038258
84Oocyte meiosis_Homo sapiens_hsa041140.59347479
85Renal cell carcinoma_Homo sapiens_hsa052110.58675890
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.58635363
87Vibrio cholerae infection_Homo sapiens_hsa051100.58488296
88Fatty acid biosynthesis_Homo sapiens_hsa000610.57588608
89Hippo signaling pathway_Homo sapiens_hsa043900.57445517
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57003097
91Hedgehog signaling pathway_Homo sapiens_hsa043400.56431416
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56264266
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56087034
94Wnt signaling pathway_Homo sapiens_hsa043100.55953851
95VEGF signaling pathway_Homo sapiens_hsa043700.55820520
96HIF-1 signaling pathway_Homo sapiens_hsa040660.55751379
97Inositol phosphate metabolism_Homo sapiens_hsa005620.55211762
98Protein digestion and absorption_Homo sapiens_hsa049740.55092851
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.54266808
100Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52693093
101Neurotrophin signaling pathway_Homo sapiens_hsa047220.52608695
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49706173
103Endometrial cancer_Homo sapiens_hsa052130.48907522
104Endocytosis_Homo sapiens_hsa041440.48290940
105Alcoholism_Homo sapiens_hsa050340.47450997
106Ovarian steroidogenesis_Homo sapiens_hsa049130.46608556
107mTOR signaling pathway_Homo sapiens_hsa041500.44320762
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.43726524
109Chemokine signaling pathway_Homo sapiens_hsa040620.43485365
110Glucagon signaling pathway_Homo sapiens_hsa049220.43344710
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41424994
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41009439
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39912677
114Nitrogen metabolism_Homo sapiens_hsa009100.39426291
115Non-small cell lung cancer_Homo sapiens_hsa052230.39362370
116Ether lipid metabolism_Homo sapiens_hsa005650.38784543
117T cell receptor signaling pathway_Homo sapiens_hsa046600.38391144
118Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38182155
119Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37393181
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.37250097
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36343440
122Insulin signaling pathway_Homo sapiens_hsa049100.35839429
123Bile secretion_Homo sapiens_hsa049760.35373404
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35055736
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32404204

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