TNFSF8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of immunoglobulin secretion (GO:0051023)7.88289905
2regulation of isotype switching to IgG isotypes (GO:0048302)7.55990199
3regulation of regulatory T cell differentiation (GO:0045589)6.44153484
4negative T cell selection (GO:0043383)6.08628101
5negative thymic T cell selection (GO:0045060)6.01070140
6positive regulation of isotype switching (GO:0045830)6.00978488
7positive regulation of gamma-delta T cell activation (GO:0046645)5.92238935
8positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.85158286
9positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.48304235
10regulation of alpha-beta T cell proliferation (GO:0046640)5.42564421
11positive regulation of DNA recombination (GO:0045911)5.24197532
12positive regulation of interleukin-17 production (GO:0032740)5.23881866
13positive regulation of alpha-beta T cell proliferation (GO:0046641)5.23052810
14regulation of gamma-delta T cell differentiation (GO:0045586)5.18615079
15positive regulation of immunoglobulin mediated immune response (GO:0002891)5.16472297
16positive regulation of B cell mediated immunity (GO:0002714)5.16472297
17regulation of interleukin-12 biosynthetic process (GO:0045075)5.07364506
18positive thymic T cell selection (GO:0045059)5.00207074
19negative regulation of cell killing (GO:0031342)4.81002349
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.81002349
21regulation of gamma-delta T cell activation (GO:0046643)4.77774368
22regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.72166253
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.69792574
24antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.69792574
25response to interleukin-15 (GO:0070672)4.67910358
26regulation of isotype switching (GO:0045191)4.65098761
27negative regulation of interleukin-12 production (GO:0032695)4.62487349
28thymic T cell selection (GO:0045061)4.61999574
29interferon-gamma production (GO:0032609)4.60239378
30positive regulation of activated T cell proliferation (GO:0042104)4.59390052
31regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.56726002
32positive T cell selection (GO:0043368)4.54690565
33positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.54205088
34T cell selection (GO:0045058)4.49989075
35positive regulation of humoral immune response (GO:0002922)4.49925033
36cellular response to interleukin-15 (GO:0071350)4.45929984
37tolerance induction (GO:0002507)4.37102258
38antigen processing and presentation of endogenous antigen (GO:0019883)4.35927929
39regulation of immunoglobulin production (GO:0002637)4.32468710
40regulation of interleukin-6 biosynthetic process (GO:0045408)4.31573488
41positive regulation of inflammatory response to antigenic stimulus (GO:0002863)4.31136390
42regulation of interleukin-2 biosynthetic process (GO:0045076)4.24221355
43positive regulation of immunoglobulin production (GO:0002639)4.23689325
44regulation of memory T cell differentiation (GO:0043380)4.22725620
45regulation of vitamin D biosynthetic process (GO:0060556)4.22392871
46regulation of immunoglobulin mediated immune response (GO:0002889)4.22341573
47T cell costimulation (GO:0031295)4.19338594
48tyrosine phosphorylation of STAT protein (GO:0007260)4.14827641
49regulation of cytokine production involved in inflammatory response (GO:1900015)4.14504236
50positive regulation of interleukin-2 production (GO:0032743)4.13609475
51lymphocyte costimulation (GO:0031294)4.12015869
52regulation of B cell mediated immunity (GO:0002712)4.09903247
53regulation of T cell tolerance induction (GO:0002664)4.04702026
54leukocyte aggregation (GO:0070486)4.02634004
55natural killer cell activation (GO:0030101)3.93840812
56regulation of chronic inflammatory response (GO:0002676)3.89898914
57T cell migration (GO:0072678)3.87166788
58negative regulation of T cell mediated immunity (GO:0002710)3.78974028
59positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.76761339
60positive regulation of natural killer cell mediated immunity (GO:0002717)3.76761339
61positive regulation of T cell chemotaxis (GO:0010820)3.74837668
62regulation of T cell chemotaxis (GO:0010819)3.74837668
63response to peptidoglycan (GO:0032494)3.73743503
64myeloid dendritic cell differentiation (GO:0043011)3.72099823
65positive regulation of T cell cytokine production (GO:0002726)3.71652706
66neutrophil activation involved in immune response (GO:0002283)3.66356071
67positive regulation of interleukin-12 production (GO:0032735)3.65727782
68regulation of interleukin-17 production (GO:0032660)3.64232620
69positive regulation of natural killer cell differentiation (GO:0032825)3.64001674
70positive regulation of lymphocyte mediated immunity (GO:0002708)3.60622871
71regulation of activation of Janus kinase activity (GO:0010533)3.60054343
72positive regulation by symbiont of host defense response (GO:0052509)3.59807411
73modulation by symbiont of host defense response (GO:0052031)3.59807411
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59807411
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59807411
76positive regulation by organism of defense response of other organism involved in symbiotic interact3.59807411
77modulation by symbiont of host immune response (GO:0052553)3.59807411
78myeloid dendritic cell activation (GO:0001773)3.58498972
79regulation of interleukin-8 biosynthetic process (GO:0045414)3.56401340
80T cell receptor signaling pathway (GO:0050852)3.56003193
81CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.54281326
82antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.53197804
83regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.52800257
84regulation of natural killer cell mediated immunity (GO:0002715)3.52800257
85T cell proliferation (GO:0042098)3.51025807
86NIK/NF-kappaB signaling (GO:0038061)3.50364483
87regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.44613246
88defense response to protozoan (GO:0042832)3.44491432
89regulation of activated T cell proliferation (GO:0046006)3.44345615
90alpha-beta T cell differentiation involved in immune response (GO:0002293)3.41417986
91alpha-beta T cell activation involved in immune response (GO:0002287)3.41417986
92T cell differentiation involved in immune response (GO:0002292)3.41417986
93regulation of B cell receptor signaling pathway (GO:0050855)3.39830806
94regulation of T-helper cell differentiation (GO:0045622)3.39661286
95positive regulation of interferon-gamma production (GO:0032729)3.39260900
96positive regulation of immune response to tumor cell (GO:0002839)3.36889574
97regulation of immune response to tumor cell (GO:0002837)3.36889574
98regulation of response to tumor cell (GO:0002834)3.36889574
99positive regulation of response to tumor cell (GO:0002836)3.36889574
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.35462476
101regulation of interleukin-2 production (GO:0032663)3.32063743
102type I interferon signaling pathway (GO:0060337)3.31255157
103cellular response to type I interferon (GO:0071357)3.31255157
104regulation of T-helper 1 cell differentiation (GO:0045625)3.31182028
105* alpha-beta T cell differentiation (GO:0046632)3.31142571
106positive regulation of T cell differentiation (GO:0045582)3.30030832
107activated T cell proliferation (GO:0050798)3.28456249
108regulation of interleukin-12 production (GO:0032655)3.28233965
109positive regulation of chemokine biosynthetic process (GO:0045080)3.28151194
110regulation of vitamin metabolic process (GO:0030656)3.27507870
111response to type I interferon (GO:0034340)3.27009556
112positive regulation of T cell proliferation (GO:0042102)3.26836550
113positive regulation of endothelial cell apoptotic process (GO:2000353)3.26400825
114response to protozoan (GO:0001562)3.24302446
115macrophage activation involved in immune response (GO:0002281)3.21418752
116regulation of T-helper 1 type immune response (GO:0002825)3.20917808
117T-helper cell differentiation (GO:0042093)3.20499352
118CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.20499352
119regulation of T cell receptor signaling pathway (GO:0050856)3.20471989
120T-helper 1 type immune response (GO:0042088)3.20234782
121positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.19606099
122positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.18547500
123regulation of tolerance induction (GO:0002643)3.18547155
124positive regulation of B cell proliferation (GO:0030890)3.17789515
125regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.16624795
126JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.16320103
127regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.15745190
128negative regulation of lymphocyte mediated immunity (GO:0002707)3.15459403
129positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.14690238
130positive regulation of leukocyte mediated immunity (GO:0002705)3.14526647
131positive regulation of tolerance induction (GO:0002645)3.13551227
132regulation of lymphocyte mediated immunity (GO:0002706)3.13518629
133cellular extravasation (GO:0045123)3.09914985
134negative regulation of T-helper cell differentiation (GO:0045623)3.08898414
135negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.08898414
136* alpha-beta T cell activation (GO:0046631)3.07564384
137negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.06917649
138negative regulation of cytokine production involved in immune response (GO:0002719)3.04105365
139cytokine biosynthetic process (GO:0042089)3.03421027
140regulation of interleukin-1 beta secretion (GO:0050706)3.00960423
141granulocyte activation (GO:0036230)3.00588463
142dendritic cell differentiation (GO:0097028)3.00586993
143positive regulation of interleukin-1 beta secretion (GO:0050718)2.99658843
144interferon-gamma-mediated signaling pathway (GO:0060333)2.95763357
145regulation of T cell mediated cytotoxicity (GO:0001914)2.95721594
146regulation of chemokine biosynthetic process (GO:0045073)2.95205675
147detection of other organism (GO:0098543)2.94606509
148neutrophil activation (GO:0042119)2.94396142

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.73457767
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human6.19730431
3IRF8_22096565_ChIP-ChIP_GC-B_Human5.32688341
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.12386739
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.48443314
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.44126510
7* STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.40114431
8IRF8_21731497_ChIP-ChIP_J774_Mouse4.00096832
9* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.98738840
10* RUNX_20019798_ChIP-Seq_JUKART_Human3.63130381
11MYB_26560356_Chip-Seq_TH2_Human3.22342406
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.11779116
13MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.96553731
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.89331183
15SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.74761529
16NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.72027062
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.71659561
18MAF_26560356_Chip-Seq_TH1_Human2.70736863
19EGR1_19374776_ChIP-ChIP_THP-1_Human2.69919285
20MYC_22102868_ChIP-Seq_BL_Human2.59098970
21MYB_26560356_Chip-Seq_TH1_Human2.55331133
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.54171605
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53123535
24NOTCH1_21737748_ChIP-Seq_TLL_Human2.37651917
25E2F7_22180533_ChIP-Seq_HELA_Human2.29157904
26MYB_21317192_ChIP-Seq_ERMYB_Mouse2.21416797
27UTX_26944678_Chip-Seq_JUKART_Human2.15051918
28GATA3_27048872_Chip-Seq_THYMUS_Human1.95684591
29MAF_26560356_Chip-Seq_TH2_Human1.90537506
30SPI1_23547873_ChIP-Seq_NB4_Human1.76391653
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75937050
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71752436
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.68795632
34SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61915112
35TCF7_22412390_ChIP-Seq_EML_Mouse1.57815482
36VDR_21846776_ChIP-Seq_THP-1_Human1.56331477
37ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54369433
38VDR_24763502_ChIP-Seq_THP-1_Human1.53945696
39BRD4_27068464_Chip-Seq_AML-cells_Mouse1.52146458
40RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.45952474
41PU_27001747_Chip-Seq_BMDM_Mouse1.45843880
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37330051
43GATA3_26560356_Chip-Seq_TH2_Human1.36305936
44* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35201158
45GATA1_22025678_ChIP-Seq_K562_Human1.34881431
46SCL_19346495_ChIP-Seq_HPC-7_Human1.32877377
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.31189140
48KDM2B_26808549_Chip-Seq_DND41_Human1.28429457
49CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27466565
50VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.27187151
51PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24737399
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.24419353
53NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24233910
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.23769841
55SPI1_23127762_ChIP-Seq_K562_Human1.20739708
56EGR1_19032775_ChIP-ChIP_M12_Human1.20001303
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.19860919
58CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17352511
59Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.14177506
60CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13246799
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11436537
62* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.07573158
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.06297997
64SMAD_19615063_ChIP-ChIP_OVARY_Human1.02560156
65KDM2B_26808549_Chip-Seq_JURKAT_Human0.98763251
66* VDR_24787735_ChIP-Seq_THP-1_Human0.95675828
67PCGF2_27294783_Chip-Seq_ESCs_Mouse0.94836679
68GATA2_21666600_ChIP-Seq_HMVEC_Human0.94420749
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.93813383
70ELK3_25401928_ChIP-Seq_HUVEC_Human0.93478760
71LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.92758103
72ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92137019
73TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.91759163
74ELK1_19687146_ChIP-ChIP_HELA_Human0.91108017
75CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89837630
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87886577
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.86562965
78PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85974302
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85907285
80STAT1_20625510_ChIP-Seq_HELA_Human0.84157649
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83478184
82PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82084230
83TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.81527290
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80133378
85GATA1_19941826_ChIP-Seq_K562_Human0.79956394
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78492412
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77487847
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77335237
89PU.1_20513432_ChIP-Seq_Bcells_Mouse0.76949418
90SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.75664611
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.75271431
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.73264547
93HOXB4_20404135_ChIP-ChIP_EML_Mouse0.72409441
94THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.72354409
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71565359
96* VDR_23849224_ChIP-Seq_CD4+_Human0.65788537
97HIF1A_21447827_ChIP-Seq_MCF-7_Human0.62279594
98GATA1_22383799_ChIP-Seq_G1ME_Mouse0.60755673
99GATA1_19941827_ChIP-Seq_MEL_Mouse0.58593901
100GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.55839462
101ERG_20887958_ChIP-Seq_HPC-7_Mouse0.55809611
102RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.55533861
103LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.55422754
104NCOR1_26117541_ChIP-Seq_K562_Human0.55389579
105RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.54185895
106SMRT_27268052_Chip-Seq_Bcells_Human0.54117636
107EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.53987290
108GATA3_26560356_Chip-Seq_TH1_Human0.53319361
109* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.52499821
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.51534544
111* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.50793794

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.55290600
2* MP0005671_abnormal_response_to4.49619528
3MP0000685_abnormal_immune_system4.42509496
4MP0003763_abnormal_thymus_physiology4.25422401
5MP0003436_decreased_susceptibility_to3.79028005
6MP0003300_gastrointestinal_ulcer3.61286668
7MP0009785_altered_susceptibility_to3.41942405
8MP0005000_abnormal_immune_tolerance3.36810494
9MP0005387_immune_system_phenotype3.23526001
10MP0001790_abnormal_immune_system3.23526001
11MP0002148_abnormal_hypersensitivity_rea3.11885792
12MP0001800_abnormal_humoral_immune3.06246251
13MP0001853_heart_inflammation2.86761110
14MP0002723_abnormal_immune_serum2.82120677
15MP0009333_abnormal_splenocyte_physiolog2.79314240
16MP0006082_CNS_inflammation2.79251344
17MP0005025_abnormal_response_to2.76071031
18MP0002405_respiratory_system_inflammati2.75987912
19MP0002452_abnormal_antigen_presenting2.60372077
20MP0002420_abnormal_adaptive_immunity2.58526871
21MP0001819_abnormal_immune_cell2.57667066
22MP0003303_peritoneal_inflammation2.57429499
23MP0003724_increased_susceptibility_to2.52581825
24MP0002398_abnormal_bone_marrow2.44033733
25MP0000604_amyloidosis2.39874620
26MP0002166_altered_tumor_susceptibility2.33983627
27MP0010155_abnormal_intestine_physiology2.18817983
28MP0000716_abnormal_immune_system2.16489244
29MP0002419_abnormal_innate_immunity2.13349626
30MP0000465_gastrointestinal_hemorrhage2.12879052
31MP0002006_tumorigenesis2.12817524
32MP0004510_myositis2.12275270
33MP0003866_abnormal_defecation2.04062304
34MP0000689_abnormal_spleen_morphology1.92746737
35MP0004947_skin_inflammation1.92726042
36MP0000703_abnormal_thymus_morphology1.92127237
37MP0002722_abnormal_immune_system1.87673598
38MP0001845_abnormal_inflammatory_respons1.82316245
39MP0002933_joint_inflammation1.82232787
40MP0001533_abnormal_skeleton_physiology1.75371955
41MP0002429_abnormal_blood_cell1.73635182
42MP0002396_abnormal_hematopoietic_system1.58238529
43MP0001873_stomach_inflammation1.51833824
44MP0003448_altered_tumor_morphology1.49284828
45MP0005464_abnormal_platelet_physiology1.42131363
46MP0004808_abnormal_hematopoietic_stem1.38523808
47MP0009764_decreased_sensitivity_to1.29460262
48MP0008469_abnormal_protein_level1.28646927
49MP0003172_abnormal_lysosome_physiology1.27442134
50MP0000858_altered_metastatic_potential1.25400046
51MP0002138_abnormal_hepatobiliary_system1.14301065
52MP0005310_abnormal_salivary_gland1.13234225
53MP0002998_abnormal_bone_remodeling1.12151421
54MP0003828_pulmonary_edema1.11299581
55MP0008057_abnormal_DNA_replication1.07844291
56MP0002277_abnormal_respiratory_mucosa1.05251633
57MP0001545_abnormal_hematopoietic_system1.04326677
58MP0005397_hematopoietic_system_phenotyp1.04326677
59MP0008004_abnormal_stomach_pH1.03606154
60MP0002254_reproductive_system_inflammat1.02579266
61MP0005451_abnormal_body_composition1.00098138
62MP0001881_abnormal_mammary_gland0.98993047
63MP0003329_amyloid_beta_deposits0.98009154
64MP0004381_abnormal_hair_follicle0.95627118
65MP0001851_eye_inflammation0.91909828
66MP0000490_abnormal_crypts_of0.91713764
67MP0001849_ear_inflammation0.88298931
68MP0005390_skeleton_phenotype0.83389178
69MP0005058_abnormal_lysosome_morphology0.81435839
70MP0005167_abnormal_blood-brain_barrier0.80072592
71MP0005076_abnormal_cell_differentiation0.79594628
72MP0009763_increased_sensitivity_to0.79571052
73MP0002019_abnormal_tumor_incidence0.79043262
74MP0003191_abnormal_cellular_cholesterol0.78866171
75MP0009765_abnormal_xenobiotic_induced0.76628763
76MP0002332_abnormal_exercise_endurance0.73715816
77MP0004782_abnormal_surfactant_physiolog0.72621706
78MP0000627_abnormal_mammary_gland0.69125267
79MP0008260_abnormal_autophagy0.68486921
80MP0009840_abnormal_foam_cell0.67011655
81MP0000249_abnormal_blood_vessel0.66706950
82MP0003690_abnormal_glial_cell0.65898020
83MP0005166_decreased_susceptibility_to0.65497369
84MP0003795_abnormal_bone_structure0.65474845
85MP0010352_gastrointestinal_tract_polyps0.63460010
86MP0001348_abnormal_lacrimal_gland0.62564574
87MP0000343_altered_response_to0.59148860
88MP0005023_abnormal_wound_healing0.58552014
89MP0005381_digestive/alimentary_phenotyp0.57292806
90MP0002132_abnormal_respiratory_system0.57278012
91MP0003091_abnormal_cell_migration0.57112568
92MP0008961_abnormal_basal_metabolism0.55205092
93MP0002693_abnormal_pancreas_physiology0.55191813
94MP0003045_fibrosis0.55121363
95MP0005164_abnormal_response_to0.54332896
96MP0003453_abnormal_keratinocyte_physiol0.54280719
97MP0010307_abnormal_tumor_latency0.53723353
98MP0004883_abnormal_blood_vessel0.51343970
99MP0002009_preneoplasia0.49732897
100MP0005075_abnormal_melanosome_morpholog0.49371958
101MP0005319_abnormal_enzyme/_coenzyme0.49110618
102MP0001663_abnormal_digestive_system0.49045384
103MP0003656_abnormal_erythrocyte_physiolo0.48998908
104MP0000609_abnormal_liver_physiology0.48572324
105MP0008875_abnormal_xenobiotic_pharmacok0.47860285
106MP0001243_abnormal_dermal_layer0.45957522
107MP0002136_abnormal_kidney_physiology0.45779697
108MP0003195_calcinosis0.45480033
109MP0001765_abnormal_ion_homeostasis0.43969637
110MP0008007_abnormal_cellular_replicative0.42529468
111MP0003075_altered_response_to0.40777170
112MP0001191_abnormal_skin_condition0.35877013
113MP0004742_abnormal_vestibular_system0.35086384
114MP0001216_abnormal_epidermal_layer0.34863051
115MP0002163_abnormal_gland_morphology0.34737807
116MP0005165_increased_susceptibility_to0.32194151
117MP0009278_abnormal_bone_marrow0.31053128
118MP0001501_abnormal_sleep_pattern0.30393118
119MP0008873_increased_physiological_sensi0.30315901
120MP0000920_abnormal_myelination0.27161127
121MP0000477_abnormal_intestine_morphology0.26748581
122MP0003566_abnormal_cell_adhesion0.26486392

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)9.53205022
2Increased IgM level (HP:0003496)7.41473782
3Elevated erythrocyte sedimentation rate (HP:0003565)6.44847893
4T lymphocytopenia (HP:0005403)6.28186701
5Abnormality of T cell number (HP:0011839)6.23337267
6Gastrointestinal infarctions (HP:0005244)6.08487529
7Eczematoid dermatitis (HP:0000976)5.38876675
8IgA deficiency (HP:0002720)5.26862471
9Abnormality of T cells (HP:0002843)5.22433987
10IgG deficiency (HP:0004315)4.86124910
11Recurrent fungal infections (HP:0002841)4.58879733
12Severe combined immunodeficiency (HP:0004430)4.42108647
13Recurrent bronchitis (HP:0002837)4.20677392
14Abnormality of T cell physiology (HP:0011840)4.19406091
15Combined immunodeficiency (HP:0005387)4.19303770
16Mediastinal lymphadenopathy (HP:0100721)4.11750783
17Chronic diarrhea (HP:0002028)3.90134224
18Hypergammaglobulinemia (HP:0010702)3.89028448
19Recurrent viral infections (HP:0004429)3.88526358
20Increased density of long bones (HP:0006392)3.83426354
21Vasculitis (HP:0002633)3.81138792
22Recurrent abscess formation (HP:0002722)3.80175047
23Myositis (HP:0100614)3.78624408
24Chronic otitis media (HP:0000389)3.69110099
25Chest pain (HP:0100749)3.58267538
26Nasal polyposis (HP:0100582)3.56724749
27Gingivitis (HP:0000230)3.55616924
28Amaurosis fugax (HP:0100576)3.54751165
29Joint swelling (HP:0001386)3.53005846
30Chronic mucocutaneous candidiasis (HP:0002728)3.50908242
31Recurrent cutaneous fungal infections (HP:0011370)3.50908242
32Panhypogammaglobulinemia (HP:0003139)3.42519121
33Retrobulbar optic neuritis (HP:0100654)3.39203039
34Optic neuritis (HP:0100653)3.39203039
35Arterial thrombosis (HP:0004420)3.35465026
36IgM deficiency (HP:0002850)3.30239492
37Thrombocytosis (HP:0001894)3.27690974
38Persistence of primary teeth (HP:0006335)3.25980100
39Hemoptysis (HP:0002105)3.16733104
40B lymphocytopenia (HP:0010976)3.15234282
41Abnormality of B cell number (HP:0010975)3.15234282
42Leukocytosis (HP:0001974)3.08277916
43Orchitis (HP:0100796)3.06342871
44Autoimmune thrombocytopenia (HP:0001973)3.02553208
45Abnormality of the nasal mucosa (HP:0000433)2.97611850
46Obstructive lung disease (HP:0006536)2.96069220
47Chronic obstructive pulmonary disease (HP:0006510)2.96069220
48Recurrent bacterial skin infections (HP:0005406)2.94673853
49Pulmonary infiltrates (HP:0002113)2.90956870
50Abnormality of eosinophils (HP:0001879)2.86559548
51Abnormal delayed hypersensitivity skin test (HP:0002963)2.82725124
52Cheilitis (HP:0100825)2.81106949
53Loss of speech (HP:0002371)2.75230315
54Meningitis (HP:0001287)2.72816632
55Autoimmune hemolytic anemia (HP:0001890)2.71942629
56Pustule (HP:0200039)2.71845538
57Recurrent skin infections (HP:0001581)2.69186841
58Lymphopenia (HP:0001888)2.68568622
59Abnormality of cells of the lymphoid lineage (HP:0012140)2.67693981
60Episodic fever (HP:0001954)2.62180761
61Eosinophilia (HP:0001880)2.61085271
62Increased cerebral lipofuscin (HP:0011813)2.60964065
63Myocardial infarction (HP:0001658)2.59849596
64Gangrene (HP:0100758)2.57448122
65Gingival bleeding (HP:0000225)2.55911338
66Polyneuropathy (HP:0001271)2.54549613
67Basal ganglia calcification (HP:0002135)2.52398885
68Abnormality of the endocardium (HP:0004306)2.43902128
69Lymphoma (HP:0002665)2.40588377
70Thyroiditis (HP:0100646)2.40560164
71Abnormality of the fingertips (HP:0001211)2.37450970
72Hepatitis (HP:0012115)2.36609962
73Recurrent gram-negative bacterial infections (HP:0005420)2.35676331
74Bronchitis (HP:0012387)2.34027498
75Fatigue (HP:0012378)2.33364322
76Keratitis (HP:0000491)2.33218034
77Abnormality of macrophages (HP:0004311)2.33179296
78Anorexia (HP:0002039)2.32730285
79Urticaria (HP:0001025)2.32367706
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.30562661
81Periodontitis (HP:0000704)2.28807156
82Abnormality of the prostate (HP:0008775)2.26748600
83Recurrent sinusitis (HP:0011108)2.24968044
84Arthralgia (HP:0002829)2.22537073
85Granulocytopenia (HP:0001913)2.21683429
86Porencephaly (HP:0002132)2.16217801
87Skin rash (HP:0000988)2.14160119
88Keratoconjunctivitis sicca (HP:0001097)2.13593886
89Gastrointestinal stroma tumor (HP:0100723)2.11701303
90Encephalitis (HP:0002383)2.11400144
91Peritonitis (HP:0002586)2.10468299
92Spontaneous hematomas (HP:0007420)2.10151642
93Abnormality of glycolipid metabolism (HP:0010969)2.09586822
94Abnormality of liposaccharide metabolism (HP:0010968)2.09586822
95Abnormality of glycosphingolipid metabolism (HP:0004343)2.09586822
96Prolonged bleeding time (HP:0003010)2.06699592
97Vacuolated lymphocytes (HP:0001922)2.06671945
98Glomerulopathy (HP:0100820)2.06668982
99Inflammation of the large intestine (HP:0002037)2.05082896
100Agammaglobulinemia (HP:0004432)2.01548890
101Abnormality of the pleura (HP:0002103)2.01351541
102Hepatosplenomegaly (HP:0001433)2.00275184
103Pulmonary embolism (HP:0002204)2.00198452
104Hypoplasia of the thymus (HP:0000778)1.99870985
105Abnormality of the peritoneum (HP:0002585)1.99021214
106Chronic sinusitis (HP:0011109)1.98978332
107Epistaxis (HP:0000421)1.98124679
108Vertigo (HP:0002321)1.96140244
109Emphysema (HP:0002097)1.94547303
110Acute myeloid leukemia (HP:0004808)1.92669518
111Gastrointestinal inflammation (HP:0004386)1.91882956
112Premature loss of primary teeth (HP:0006323)1.91789855
113Keratoconjunctivitis (HP:0001096)1.91696456
114Acute hepatic failure (HP:0006554)1.91644921
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89522894
116Amyloidosis (HP:0011034)1.88387746
117Increased IgE level (HP:0003212)1.87627473
118Neutropenia (HP:0001875)1.84970159
119Abnormality of the pericardium (HP:0001697)1.84732799
120Interstitial pulmonary disease (HP:0006530)1.83955646
121Acne (HP:0001061)1.82505625
122Mutism (HP:0002300)1.82177575
123Dysostosis multiplex (HP:0000943)1.81699603
124Hematochezia (HP:0002573)1.81346333
125Somatic mutation (HP:0001428)1.81037046
126Stomach cancer (HP:0012126)1.79198133

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.23896600
2MAP4K15.77030749
3JAK34.14285246
4MAP3K144.07334278
5ZAP703.54226164
6ITK2.96377663
7IKBKE2.64815274
8TYK22.55679483
9TBK12.35214530
10IKBKB2.24164199
11PIM22.21797635
12TEC2.02269040
13FGFR41.97832854
14IRAK41.93122457
15JAK11.90513465
16PRPF4B1.88858439
17MAP3K131.86407612
18CHUK1.78383076
19LCK1.77579065
20NME21.74497261
21CSK1.62303576
22STK101.54764981
23ERN11.53046523
24NLK1.48803188
25BLK1.48128974
26SYK1.45017442
27HCK1.43170794
28MST41.35859871
29GRK71.33114258
30FGFR31.27380950
31PRKCQ1.26842326
32BTK1.26704201
33PIM11.26616736
34CAMKK21.25229410
35FGR1.20820043
36MAP3K111.09806294
37BMPR21.09034096
38EEF2K1.08994184
39MATK1.06145369
40KDR1.04697214
41JAK21.03980695
42IRAK11.03161886
43RPS6KA41.03161032
44GRK60.99734320
45MAP2K60.98254028
46TAOK10.92826931
47KIT0.88201565
48NEK90.84688946
49SIK30.84604767
50LYN0.84194481
51PRKCH0.83469499
52ACVR1B0.82345364
53PBK0.80495771
54IRAK30.79443460
55MAP3K70.79091700
56FES0.78940541
57TRIB30.78400514
58EPHA30.77794181
59MARK30.76261999
60ADRBK20.74245731
61LRRK20.72125051
62IRAK20.71602494
63MOS0.68998334
64CAMKK10.68610104
65RIPK40.66449498
66MAP2K30.65228312
67PIK3CG0.65222411
68SIK20.64069122
69MAP3K100.63814019
70PASK0.61025559
71EPHB10.59375257
72STK40.58685747
73MST1R0.58188966
74CDK120.54781451
75TYRO30.54312470
76ALK0.52726226
77RPS6KC10.48423087
78RPS6KL10.48423087
79TAOK20.47657681
80RPS6KA60.47069532
81MAP3K30.46993622
82TLK10.44260150
83PDGFRB0.44129199
84MAPK70.43001545
85NTRK20.42758269
86TAOK30.42458169
87IGF1R0.41861099
88MAPK120.41316031
89CDC42BPA0.40928454
90STK240.40906435
91RAF10.40567624
92TNK20.39144441
93CLK10.39057697
94MAP3K10.38092924
95CDK60.37906611
96RPS6KA50.37873560
97ABL10.37811451
98BCKDK0.37742622
99MAP3K50.36320547
100SGK30.35762865
101INSR0.35534575
102EGFR0.34109594
103WNK10.32861912
104CDK40.32073467
105TRPM70.31906597
106TESK20.31379235
107PKN20.30794956
108BMX0.30741106
109PDK10.30562879
110MAPKAPK20.29592467
111NUAK10.29297650
112SGK20.28055163
113CSF1R0.27100828
114RPS6KA10.25893471
115MAP3K80.25280572
116PDPK10.22993268
117SIK10.21160185
118MAP3K120.20737423
119FYN0.20552391
120MAPK30.20345776
121FGFR10.19115763
122KSR20.18602727
123HIPK20.18487580
124MAPK110.18064327
125PRKCD0.17111553
126TGFBR20.16625043
127MELK0.15066105
128TTN0.13747250

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053305.94418770
2Graft-versus-host disease_Homo sapiens_hsa053324.02740628
3Autoimmune thyroid disease_Homo sapiens_hsa053203.88820985
4Primary immunodeficiency_Homo sapiens_hsa053403.78955902
5Asthma_Homo sapiens_hsa053103.57086291
6Intestinal immune network for IgA production_Homo sapiens_hsa046723.42196846
7Type I diabetes mellitus_Homo sapiens_hsa049403.40799496
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.15915785
9T cell receptor signaling pathway_Homo sapiens_hsa046603.02469317
10NF-kappa B signaling pathway_Homo sapiens_hsa040642.91963132
11Measles_Homo sapiens_hsa051622.54785234
12Leishmaniasis_Homo sapiens_hsa051402.07565065
13Viral myocarditis_Homo sapiens_hsa054161.97586892
14Jak-STAT signaling pathway_Homo sapiens_hsa046301.91342723
15Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86178860
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.80313899
17Osteoclast differentiation_Homo sapiens_hsa043801.71681001
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.70620946
19* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.67571591
20Hematopoietic cell lineage_Homo sapiens_hsa046401.62702733
21Toxoplasmosis_Homo sapiens_hsa051451.53333755
22Toll-like receptor signaling pathway_Homo sapiens_hsa046201.52293979
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51901844
24TNF signaling pathway_Homo sapiens_hsa046681.51211489
25Herpes simplex infection_Homo sapiens_hsa051681.42071535
26Malaria_Homo sapiens_hsa051441.38087942
27Caffeine metabolism_Homo sapiens_hsa002321.36966166
28Antigen processing and presentation_Homo sapiens_hsa046121.36272180
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28433171
30Legionellosis_Homo sapiens_hsa051341.27623441
31Influenza A_Homo sapiens_hsa051641.24243259
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.23408571
33B cell receptor signaling pathway_Homo sapiens_hsa046621.20184963
34Rheumatoid arthritis_Homo sapiens_hsa053231.18647563
35Chemokine signaling pathway_Homo sapiens_hsa040621.14438190
36Acute myeloid leukemia_Homo sapiens_hsa052211.09270188
37Hepatitis B_Homo sapiens_hsa051611.05622618
38Pertussis_Homo sapiens_hsa051331.05256950
39Prolactin signaling pathway_Homo sapiens_hsa049171.00677629
40Apoptosis_Homo sapiens_hsa042100.98676947
41Other glycan degradation_Homo sapiens_hsa005110.97995944
42Tuberculosis_Homo sapiens_hsa051520.96512874
43Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92181798
44Shigellosis_Homo sapiens_hsa051310.84437858
45HTLV-I infection_Homo sapiens_hsa051660.83626773
46Chronic myeloid leukemia_Homo sapiens_hsa052200.82062692
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82043404
48African trypanosomiasis_Homo sapiens_hsa051430.78313799
49Salmonella infection_Homo sapiens_hsa051320.71877240
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71084582
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.70364463
52Hepatitis C_Homo sapiens_hsa051600.69729675
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.69217944
54Staphylococcus aureus infection_Homo sapiens_hsa051500.69208845
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.68280573
56Lysosome_Homo sapiens_hsa041420.67165714
57Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66618507
58Epstein-Barr virus infection_Homo sapiens_hsa051690.66142108
59Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61578388
60Viral carcinogenesis_Homo sapiens_hsa052030.58751781
61Pancreatic cancer_Homo sapiens_hsa052120.54183087
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48086346
63Small cell lung cancer_Homo sapiens_hsa052220.47429936
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.46449512
65Regulation of autophagy_Homo sapiens_hsa041400.43099003
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.42625374
67Platelet activation_Homo sapiens_hsa046110.40707117
68Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39090226
69Colorectal cancer_Homo sapiens_hsa052100.34935782
70p53 signaling pathway_Homo sapiens_hsa041150.34533468
71Amoebiasis_Homo sapiens_hsa051460.33294837
72VEGF signaling pathway_Homo sapiens_hsa043700.33028345
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32826615
74Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31990307
75HIF-1 signaling pathway_Homo sapiens_hsa040660.30775879
76MAPK signaling pathway_Homo sapiens_hsa040100.30472505
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30058866
78Type II diabetes mellitus_Homo sapiens_hsa049300.28887212
79Prostate cancer_Homo sapiens_hsa052150.25960949
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24221252
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.24086290
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.22323993
83MicroRNAs in cancer_Homo sapiens_hsa052060.20896168
84Systemic lupus erythematosus_Homo sapiens_hsa053220.20545662
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.20032273
86Non-small cell lung cancer_Homo sapiens_hsa052230.18437020
87Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.17730755
88Renal cell carcinoma_Homo sapiens_hsa052110.16682621
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.16604205
90Endometrial cancer_Homo sapiens_hsa052130.16315598
91Insulin resistance_Homo sapiens_hsa049310.15278074
92Notch signaling pathway_Homo sapiens_hsa043300.14000342
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12786971
94FoxO signaling pathway_Homo sapiens_hsa040680.11900367
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.11597275
96Dorso-ventral axis formation_Homo sapiens_hsa043200.11530979
97Thyroid cancer_Homo sapiens_hsa052160.11187027
98mTOR signaling pathway_Homo sapiens_hsa041500.10913856
99Proteoglycans in cancer_Homo sapiens_hsa052050.10804385
100Prion diseases_Homo sapiens_hsa050200.10479458
101Phagosome_Homo sapiens_hsa041450.09698313
102Spliceosome_Homo sapiens_hsa030400.09693881
103Endocytosis_Homo sapiens_hsa041440.08890701
104Pathways in cancer_Homo sapiens_hsa052000.08838618
105PI3K-Akt signaling pathway_Homo sapiens_hsa041510.08164612
106ErbB signaling pathway_Homo sapiens_hsa040120.07108728
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.06792425
108Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.06491468
109Proteasome_Homo sapiens_hsa030500.05682875
110Collecting duct acid secretion_Homo sapiens_hsa049660.05383150
111Central carbon metabolism in cancer_Homo sapiens_hsa052300.05352774
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.05210248
113One carbon pool by folate_Homo sapiens_hsa006700.04386066
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.02853183
115Rap1 signaling pathway_Homo sapiens_hsa040150.01957310
116Inositol phosphate metabolism_Homo sapiens_hsa005620.01618222

Most similar genes based on co-expression Upload to Enrichr

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