TNFSF18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood vessel maturation (GO:0001955)7.24978899
2endothelium development (GO:0003158)6.07943649
3wound healing, spreading of epidermal cells (GO:0035313)5.91643907
4substrate-dependent cell migration (GO:0006929)5.24533218
5lymphangiogenesis (GO:0001946)5.18056806
6cellular response to ATP (GO:0071318)5.14694812
7activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)5.07745681
8microglial cell activation (GO:0001774)4.84585859
9macrophage activation involved in immune response (GO:0002281)4.82341583
10pinocytosis (GO:0006907)4.81628791
11positive regulation by symbiont of host defense response (GO:0052509)4.72520375
12modulation by symbiont of host defense response (GO:0052031)4.72520375
13modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.72520375
14modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.72520375
15positive regulation by organism of defense response of other organism involved in symbiotic interact4.72520375
16modulation by symbiont of host immune response (GO:0052553)4.72520375
17SMAD protein complex assembly (GO:0007183)4.59987629
18cyclooxygenase pathway (GO:0019371)4.56125668
19retina vasculature morphogenesis in camera-type eye (GO:0061299)4.50836235
20histamine secretion (GO:0001821)4.45350905
21regulation of chemokine-mediated signaling pathway (GO:0070099)4.39706172
22positive regulation of SMAD protein import into nucleus (GO:0060391)4.39485463
23positive regulation of endothelial cell differentiation (GO:0045603)4.03967896
24wound healing, spreading of cells (GO:0044319)4.03735231
25positive regulation of monocyte chemotaxis (GO:0090026)3.97378600
26negative regulation of nitric-oxide synthase activity (GO:0051001)3.94308039
27hemidesmosome assembly (GO:0031581)3.93072443
28response to magnesium ion (GO:0032026)3.93009629
29positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-3.92543940
30neutrophil activation involved in immune response (GO:0002283)3.91123103
31phagocytosis, engulfment (GO:0006911)3.81529389
32regulation of glomerular filtration (GO:0003093)3.81235483
33cellular response to ethanol (GO:0071361)3.80054998
34T-helper 1 type immune response (GO:0042088)3.76228093
35relaxation of cardiac muscle (GO:0055119)3.75709114
36response to methylmercury (GO:0051597)3.74962990
37negative regulation of focal adhesion assembly (GO:0051895)3.74079785
38negative regulation of cell junction assembly (GO:1901889)3.74079785
39negative regulation of adherens junction organization (GO:1903392)3.74079785
40neuronal action potential propagation (GO:0019227)3.73672653
41chondrocyte proliferation (GO:0035988)3.69330657
42regulation of SMAD protein import into nucleus (GO:0060390)3.68173164
43positive regulation of blood vessel endothelial cell migration (GO:0043536)3.67646042
44regulation of T cell tolerance induction (GO:0002664)3.64362604
45positive regulation of endothelial cell migration (GO:0010595)3.53540071
46negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.52709389
47regulation of early endosome to late endosome transport (GO:2000641)3.52408533
48sprouting angiogenesis (GO:0002040)3.48177976
49positive regulation of fibroblast migration (GO:0010763)3.46261196
50lung lobe morphogenesis (GO:0060463)3.38999589
51positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.35735690
52negative regulation of monooxygenase activity (GO:0032769)3.33218550
53regulation of fibrinolysis (GO:0051917)3.31082582
54histamine transport (GO:0051608)3.30754160
55endodermal cell differentiation (GO:0035987)3.29870003
56regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.29567326
57eosinophil chemotaxis (GO:0048245)3.29342532
58fibrinolysis (GO:0042730)3.28008706
59positive regulation of endothelial cell apoptotic process (GO:2000353)3.27775307
60apoptotic cell clearance (GO:0043277)3.25149966
61neuron remodeling (GO:0016322)3.22518832
62macrophage activation (GO:0042116)3.22386840
63negative regulation of blood vessel endothelial cell migration (GO:0043537)3.20633971
64positive regulation of interleukin-8 secretion (GO:2000484)3.20126567
65positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.19342075
66regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.19342075
67negative regulation of cardiac muscle hypertrophy (GO:0010614)3.19306564
68receptor catabolic process (GO:0032801)3.18283042
69artery development (GO:0060840)3.17872567
70transcytosis (GO:0045056)3.17513455
71positive regulation of urine volume (GO:0035810)3.16169487
72branch elongation of an epithelium (GO:0060602)3.15488153
73positive regulation of cAMP-mediated signaling (GO:0043950)3.14754707
74cellular response to interferon-alpha (GO:0035457)3.13826627
75peptidyl-tyrosine autophosphorylation (GO:0038083)3.12758949
76positive regulation of macrophage derived foam cell differentiation (GO:0010744)3.12547811
77negative regulation of platelet activation (GO:0010544)3.11720819
78positive regulation of macrophage differentiation (GO:0045651)3.11573677
79hyaluronan catabolic process (GO:0030214)3.11370268
80protein localization to endosome (GO:0036010)3.10709353
81negative regulation of chondrocyte differentiation (GO:0032331)3.10103175
82positive regulation of cardiac muscle hypertrophy (GO:0010613)3.10101249
83positive regulation of muscle hypertrophy (GO:0014742)3.10101249
84angiogenesis involved in wound healing (GO:0060055)3.09753816
85left/right pattern formation (GO:0060972)3.08912470
86tonic smooth muscle contraction (GO:0014820)3.08685505
87endothelial tube morphogenesis (GO:0061154)3.08639935
88morphogenesis of an endothelium (GO:0003159)3.08639935
89vascular endothelial growth factor receptor signaling pathway (GO:0048010)3.08076939
90cranial nerve morphogenesis (GO:0021602)3.07455568
91regulation of sarcomere organization (GO:0060297)3.07454963
92negative regulation of nitric oxide biosynthetic process (GO:0045019)3.06857710
93folic acid transport (GO:0015884)3.05969144
94regulation of dendritic cell antigen processing and presentation (GO:0002604)3.03411605
95vascular endothelial growth factor signaling pathway (GO:0038084)3.00839990
96regulation of monocyte chemotaxis (GO:0090025)3.00703870
97positive regulation of collagen biosynthetic process (GO:0032967)3.00138455
98positive regulation of cell size (GO:0045793)2.99836847
99monocyte chemotaxis (GO:0002548)2.97712604
100negative regulation of endothelial cell proliferation (GO:0001937)2.97625128
101regulation of plasminogen activation (GO:0010755)2.96337028
102positive regulation of epithelial cell migration (GO:0010634)2.95909102
103regulation of transforming growth factor beta1 production (GO:0032908)2.95788226
104regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.93599374
105adhesion of symbiont to host cell (GO:0044650)2.93274540
106virion attachment to host cell (GO:0019062)2.93274540
107regulation of nitric oxide biosynthetic process (GO:0045428)2.93004997
108positive regulation of nitric oxide biosynthetic process (GO:0045429)2.92768003
109eosinophil migration (GO:0072677)2.92312349
110neuromuscular process controlling posture (GO:0050884)2.89746038
111regulation of MHC class II biosynthetic process (GO:0045346)2.88258777
112lymph vessel development (GO:0001945)2.86331255
113positive regulation of collagen metabolic process (GO:0010714)2.85995086
114artery smooth muscle contraction (GO:0014824)2.85679870
115regulation of T-helper 1 cell differentiation (GO:0045625)2.85382899
116endothelial cell proliferation (GO:0001935)2.85036515
117ectodermal placode formation (GO:0060788)2.84432499
118regulation of blood vessel endothelial cell migration (GO:0043535)2.82957443
119positive regulation of smooth muscle cell proliferation (GO:0048661)2.82493206
120regulation of endothelial cell differentiation (GO:0045601)2.81791342
121negative regulation of anoikis (GO:2000811)2.81067217
122positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.80705476
123inositol phosphate-mediated signaling (GO:0048016)2.80033272
124pathway-restricted SMAD protein phosphorylation (GO:0060389)2.79775063
125negative regulation of muscle hypertrophy (GO:0014741)2.79154802
126positive regulation of osteoblast proliferation (GO:0033690)2.78301826
127regulation of collagen biosynthetic process (GO:0032965)2.76519431
128negative regulation of cardiac muscle tissue growth (GO:0055022)2.75805110
129negative regulation of heart growth (GO:0061117)2.75805110
130negative regulation of fibrinolysis (GO:0051918)2.75471830
131regulation of interferon-beta biosynthetic process (GO:0045357)2.74664056
132regulation of collagen metabolic process (GO:0010712)2.73031124
133positive regulation of chemokine biosynthetic process (GO:0045080)2.72476474
134positive regulation of hemostasis (GO:1900048)2.70985001
135positive regulation of blood coagulation (GO:0030194)2.70985001
136positive regulation of macrophage activation (GO:0043032)2.70744572
137positive regulation of prostaglandin secretion (GO:0032308)2.69160866
138positive regulation of calcium-mediated signaling (GO:0050850)2.67362348
139positive regulation of tolerance induction (GO:0002645)2.67013290
140negative regulation of fatty acid transport (GO:2000192)2.66648677
141angiogenesis (GO:0001525)2.66128552
142blood coagulation, intrinsic pathway (GO:0007597)2.65978733
143venous blood vessel morphogenesis (GO:0048845)2.65195092
144negative regulation of cell-matrix adhesion (GO:0001953)2.64560657
145positive regulation of smooth muscle cell migration (GO:0014911)2.64101576
146endocardial cushion development (GO:0003197)2.63581666
147regulation of endothelial cell migration (GO:0010594)2.62845065
148response to fluid shear stress (GO:0034405)2.61164318
149postsynaptic membrane organization (GO:0001941)2.60366685
150positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.59600393
151regulation of endothelial cell apoptotic process (GO:2000351)2.59460289
152regulation of fibroblast migration (GO:0010762)2.59146459
153purinergic nucleotide receptor signaling pathway (GO:0035590)2.58418964
154gland morphogenesis (GO:0022612)2.58009263
155mesodermal cell differentiation (GO:0048333)2.55990620
156embryonic body morphogenesis (GO:0010172)2.55269832
157response to host immune response (GO:0052572)2.54812892
158response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.54812892
159platelet degranulation (GO:0002576)2.54072314
160positive regulation of transforming growth factor beta receptor signaling pathway (GO:0030511)2.54055556
161positive regulation of coagulation (GO:0050820)2.53716063
162regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.53406505
163regulation of prostaglandin secretion (GO:0032306)2.52984471
164negative regulation of coagulation (GO:0050819)2.52729671
165regulation of megakaryocyte differentiation (GO:0045652)2.49752616
166regulation of clathrin-mediated endocytosis (GO:2000369)2.48720530
167positive regulation of odontogenesis (GO:0042482)2.47745313
168import into cell (GO:0098657)2.47394152
169positive regulation of epithelial to mesenchymal transition (GO:0010718)2.47178183
170positive regulation of receptor recycling (GO:0001921)2.46985861
171myeloid cell activation involved in immune response (GO:0002275)2.45242300
172cell adhesion mediated by integrin (GO:0033627)2.43399952
173sleep (GO:0030431)2.43111354
174regulation of tolerance induction (GO:0002643)2.41114479
175myeloid dendritic cell differentiation (GO:0043011)2.40320307
176chondroitin sulfate catabolic process (GO:0030207)2.40130261
177relaxation of muscle (GO:0090075)2.37690408
178sodium-independent organic anion transport (GO:0043252)2.36739884
179phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.35338331
180prostanoid metabolic process (GO:0006692)2.34940949
181prostaglandin metabolic process (GO:0006693)2.34940949
182regulation of macrophage chemotaxis (GO:0010758)2.31055829
183female mating behavior (GO:0060180)2.30948619
184regulation of mononuclear cell migration (GO:0071675)2.30841025
185long term synaptic depression (GO:0060292)2.30106014
186regulation of long-term neuronal synaptic plasticity (GO:0048169)2.29343876
187regulation of integrin-mediated signaling pathway (GO:2001044)2.28566593
188G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.28553145
189regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.27912703
190lens fiber cell differentiation (GO:0070306)2.27155405
191regulation of lymphocyte chemotaxis (GO:1901623)2.26828151
192regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.26786955
193axis elongation (GO:0003401)2.26747670

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human2.57015818
2TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.53531252
3GATA1_22025678_ChIP-Seq_K562_Human2.48711616
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.48104255
5TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.47779772
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44529264
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.40235040
8SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.37930280
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.37736802
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.34744607
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.34744607
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34577659
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.33631144
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.33577933
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.32489699
16FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.32436117
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.30514292
18EZH2_22144423_ChIP-Seq_EOC_Human2.29820230
19BRD4_25478319_ChIP-Seq_HGPS_Human2.28863436
20ELK3_25401928_ChIP-Seq_HUVEC_Human2.22024320
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.16728183
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16306917
23RARG_19884340_ChIP-ChIP_MEFs_Mouse2.11932949
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11733215
25GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11141571
26CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.06114505
27TP53_16413492_ChIP-PET_HCT116_Human2.05093301
28EGR1_19374776_ChIP-ChIP_THP-1_Human2.04679988
29PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99511353
30IRF8_22096565_ChIP-ChIP_GC-B_Human1.98254638
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.96388507
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.96293240
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94678965
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.93787525
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.91642887
36NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89770107
37EZH2_27304074_Chip-Seq_ESCs_Mouse1.89736727
38AR_21572438_ChIP-Seq_LNCaP_Human1.88778993
39PIAS1_25552417_ChIP-Seq_VCAP_Human1.84459900
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.84326401
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.82893808
42RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.81629378
43* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.79140336
44* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.79140336
45SALL4_18804426_ChIP-ChIP_XEN_Mouse1.78348533
46MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76289941
47GBX2_23144817_ChIP-Seq_PC3_Human1.75618762
48JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.73183961
49SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71800370
50AHR_22903824_ChIP-Seq_MCF-7_Human1.69442441
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.65547791
52BCAT_22108803_ChIP-Seq_LS180_Human1.65276318
53IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.62106308
54DROSHA_22980978_ChIP-Seq_HELA_Human1.61224070
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58292864
56* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57369128
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56466841
58WT1_19549856_ChIP-ChIP_CCG9911_Human1.56337526
59TAF15_26573619_Chip-Seq_HEK293_Human1.56079219
60ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52913746
61ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.52659285
62SOX2_20726797_ChIP-Seq_SW620_Human1.52015801
63* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.50346486
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.49678580
65TP53_18474530_ChIP-ChIP_U2OS_Human1.47521328
66ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.46780601
67EZH2_27294783_Chip-Seq_ESCs_Mouse1.46657262
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.41691162
69GATA1_19941826_ChIP-Seq_K562_Human1.38511328
70SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.38488201
71CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.38435833
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.38151688
73ZNF274_21170338_ChIP-Seq_K562_Hela1.36013351
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.33557245
75IRF8_21731497_ChIP-ChIP_J774_Mouse1.33103584
76P300_19829295_ChIP-Seq_ESCs_Human1.32595708
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30505347
78CDX2_20551321_ChIP-Seq_CACO-2_Human1.30416798
79TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29883382
80GATA2_21666600_ChIP-Seq_HMVEC_Human1.29814602
81HIF1A_21447827_ChIP-Seq_MCF-7_Human1.29343417
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.29004545
83STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.26084757
84ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25028660
85VDR_22108803_ChIP-Seq_LS180_Human1.24912307
86* FOXO3_23340844_ChIP-Seq_DLD1_Human1.24515996
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.24250065
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23702198
89SMAD3_21741376_ChIP-Seq_EPCs_Human1.21768807
90* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.21068731
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.19987533
92TBX20_22328084_ChIP-Seq_HEART_Mouse1.19987533
93CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.19764192
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19034047
95NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.17931488
96VDR_24787735_ChIP-Seq_THP-1_Human1.17547736
97ERG_21242973_ChIP-ChIP_JURKAT_Human1.16796787
98SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16783054
99* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16730983
100STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15146808
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.14830945
102SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12557950
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12534470
104PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12463288
105UBF1/2_26484160_Chip-Seq_HMECs_Human1.12438024
106CLOCK_20551151_ChIP-Seq_293T_Human1.12282652
107SMAD3_21741376_ChIP-Seq_HESCs_Human1.10256835
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09870930
109ESR1_20079471_ChIP-ChIP_T-47D_Human1.09785766
110* IRF8_27001747_Chip-Seq_BMDM_Mouse1.09668505
111CJUN_26792858_Chip-Seq_BT549_Human1.07866430
112* SMAD4_21799915_ChIP-Seq_A2780_Human1.07460840
113NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07093741
114NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06489900
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06489900
116TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05395909
117ESR1_21235772_ChIP-Seq_MCF-7_Human1.04460868
118OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03756477
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.02984388
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02901601
121SMAD4_21741376_ChIP-Seq_HESCs_Human1.01974747
122EP300_21415370_ChIP-Seq_HL-1_Mouse1.01417958
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01211878
124SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.00943996
125AR_25329375_ChIP-Seq_VCAP_Human1.00451755
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99858248
127SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99846691
128* TP63_23658742_ChIP-Seq_EP156T_Human0.99630136
129* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99250431
130POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99168742
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99165431
132SMAD_19615063_ChIP-ChIP_OVARY_Human0.99131992
133PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99018401
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.98941650
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97742110
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96076191
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.95991766
138TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95658405
139* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94838449
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94018620
141TP53_22127205_ChIP-Seq_IMR90_Human0.93655521
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.92725025
143TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91254601
144POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91254601
145TP53_20018659_ChIP-ChIP_R1E_Mouse0.89804930
146MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.89515638
147KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89188838
148STAT4_19710469_ChIP-ChIP_TH1__Mouse0.88728959
149FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88479934
150PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86623719
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86441973
152SMC1_22415368_ChIP-Seq_MEFs_Mouse0.85166544
153* RUNX_20019798_ChIP-Seq_JUKART_Human0.84742466
154SPI1_23127762_ChIP-Seq_K562_Human0.84518244
155NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.84327163
156PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82784791
157TP53_23651856_ChIP-Seq_MEFs_Mouse0.82680495
158* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82366043
159ATF3_27146783_Chip-Seq_COLON_Human0.81826592
160MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.75924831
161EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.74377420
162* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73917517

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005167_abnormal_blood-brain_barrier4.37198329
2MP0003705_abnormal_hypodermis_morpholog4.21280296
3MP0005409_darkened_coat_color3.89331035
4MP0009384_cardiac_valve_regurgitation3.87617522
5MP0004859_abnormal_synaptic_plasticity3.44616692
6MP0003279_aneurysm3.36805588
7MP0002254_reproductive_system_inflammat3.29788648
8MP0003690_abnormal_glial_cell3.05730737
9MP0009379_abnormal_foot_pigmentation3.05617201
10MP0003950_abnormal_plasma_membrane2.95373338
11MP0001851_eye_inflammation2.63222232
12MP0009840_abnormal_foam_cell2.52746728
13MP0003172_abnormal_lysosome_physiology2.42864682
14MP0003091_abnormal_cell_migration2.42642540
15MP0003300_gastrointestinal_ulcer2.36056067
16MP0000767_abnormal_smooth_muscle2.23127015
17MP0004233_abnormal_muscle_weight2.19771957
18MP0010352_gastrointestinal_tract_polyps2.15472561
19MP0002877_abnormal_melanocyte_morpholog2.10065382
20MP0002332_abnormal_exercise_endurance2.08757068
21MP0010368_abnormal_lymphatic_system2.05709330
22MP0006082_CNS_inflammation2.02454876
23MP0003941_abnormal_skin_development1.91087552
24MP0003303_peritoneal_inflammation1.88637628
25MP0005164_abnormal_response_to1.87047588
26MP0004883_abnormal_blood_vessel1.86676027
27MP0003191_abnormal_cellular_cholesterol1.85950949
28MP0005058_abnormal_lysosome_morphology1.77128505
29MP0000920_abnormal_myelination1.72732730
30MP0004270_analgesia1.70770818
31MP0003075_altered_response_to1.65202908
32MP0008004_abnormal_stomach_pH1.65098622
33MP0004272_abnormal_basement_membrane1.63499251
34MP0005000_abnormal_immune_tolerance1.63046222
35MP0005197_abnormal_uvea_morphology1.62008822
36MP0003635_abnormal_synaptic_transmissio1.60705620
37MP0004510_myositis1.60431978
38MP0003868_abnormal_feces_composition1.56081546
39MP0005257_abnormal_intraocular_pressure1.53611995
40MP0003448_altered_tumor_morphology1.52963756
41MP0000569_abnormal_digit_pigmentation1.52826606
42MP0002090_abnormal_vision1.48241298
43MP0000343_altered_response_to1.47396378
44MP0002909_abnormal_adrenal_gland1.47299670
45MP0003724_increased_susceptibility_to1.47054657
46MP0001542_abnormal_bone_strength1.46232450
47MP0005595_abnormal_vascular_smooth1.45661081
48MP0005174_abnormal_tail_pigmentation1.43495149
49MP0009764_decreased_sensitivity_to1.42716537
50MP0001348_abnormal_lacrimal_gland1.42202316
51MP0002138_abnormal_hepatobiliary_system1.42178754
52MP0001727_abnormal_embryo_implantation1.37947384
53MP0000249_abnormal_blood_vessel1.37636546
54MP0002148_abnormal_hypersensitivity_rea1.33740984
55MP0005464_abnormal_platelet_physiology1.32891566
56MP0009780_abnormal_chondrocyte_physiolo1.29692499
57MP0001915_intracranial_hemorrhage1.28152554
58MP0003045_fibrosis1.27493755
59MP0001835_abnormal_antigen_presentation1.23739125
60MP0002933_joint_inflammation1.23318362
61MP0005166_decreased_susceptibility_to1.23211382
62MP0002419_abnormal_innate_immunity1.21683805
63MP0002063_abnormal_learning/memory/cond1.21124214
64MP0009785_altered_susceptibility_to1.18645711
65MP0000566_synostosis1.17709968
66MP0009046_muscle_twitch1.16559987
67MP0001853_heart_inflammation1.16276608
68MP0002168_other_aberrant_phenotype1.13424678
69MP0003436_decreased_susceptibility_to1.13239663
70MP0008438_abnormal_cutaneous_collagen1.12585206
71MP0002282_abnormal_trachea_morphology1.11606758
72MP0005646_abnormal_pituitary_gland1.07195343
73MP0000858_altered_metastatic_potential1.05595344
74MP0002572_abnormal_emotion/affect_behav1.04496712
75MP0004133_heterotaxia1.04287391
76MP0002064_seizures1.04067506
77MP0005165_increased_susceptibility_to1.04034332
78MP0009745_abnormal_behavioral_response1.02461840
79MP0002452_abnormal_antigen_presenting1.00067557
80MP0006054_spinal_hemorrhage0.99574285
81MP0001958_emphysema0.99382330
82MP0001440_abnormal_grooming_behavior0.99202437
83MP0006138_congestive_heart_failure0.99012392
84MP0001188_hyperpigmentation0.98187106
85MP0001486_abnormal_startle_reflex0.97290470
86MP0005275_abnormal_skin_tensile0.97077580
87MP0005310_abnormal_salivary_gland0.96319962
88MP0005623_abnormal_meninges_morphology0.94803249
89MP0003880_abnormal_central_pattern0.94322399
90MP0000465_gastrointestinal_hemorrhage0.93328591
91MP0001849_ear_inflammation0.93072972
92MP0008874_decreased_physiological_sensi0.92417699
93MP0002998_abnormal_bone_remodeling0.90483993
94MP0008875_abnormal_xenobiotic_pharmacok0.90009155
95MP0005085_abnormal_gallbladder_physiolo0.89136010
96MP0002092_abnormal_eye_morphology0.89132699
97MP0005390_skeleton_phenotype0.88987164
98MP0004484_altered_response_of0.88767164
99MP0005360_urolithiasis0.87959094
100MP0002272_abnormal_nervous_system0.87883707
101MP0002925_abnormal_cardiovascular_devel0.87842962
102MP0000613_abnormal_salivary_gland0.87236431
103MP0005503_abnormal_tendon_morphology0.86624262
104MP0010155_abnormal_intestine_physiology0.85574176
105MP0002060_abnormal_skin_morphology0.85529122
106MP0001501_abnormal_sleep_pattern0.85520984
107MP0004085_abnormal_heartbeat0.83735826
108MP0003633_abnormal_nervous_system0.83498128
109MP0002295_abnormal_pulmonary_circulatio0.83237289
110MP0001614_abnormal_blood_vessel0.82720973
111MP0002723_abnormal_immune_serum0.82083442
112MP0000751_myopathy0.80124243
113MP0001800_abnormal_humoral_immune0.79864098
114MP0003828_pulmonary_edema0.78371336
115MP0009250_abnormal_appendicular_skeleto0.77701105
116MP0003385_abnormal_body_wall0.76517474
117MP0000230_abnormal_systemic_arterial0.76061591
118MP0002638_abnormal_pupillary_reflex0.76013630
119MP0001340_abnormal_eyelid_morphology0.74730359
120MP0001533_abnormal_skeleton_physiology0.74077505
121MP0002405_respiratory_system_inflammati0.73319282
122MP0002128_abnormal_blood_circulation0.72528506
123MP0002136_abnormal_kidney_physiology0.72300346
124MP0010386_abnormal_urinary_bladder0.72242762
125MP0009643_abnormal_urine_homeostasis0.71482226
126MP0005508_abnormal_skeleton_morphology0.71101019
127MP0003938_abnormal_ear_development0.70933666
128MP0001879_abnormal_lymphatic_vessel0.70798691
129MP0003634_abnormal_glial_cell0.70511031
130MP0005621_abnormal_cell_physiology0.70340459
131MP0003566_abnormal_cell_adhesion0.70204421
132MP0003453_abnormal_keratinocyte_physiol0.70156810
133MP0002249_abnormal_larynx_morphology0.70052178
134MP0002896_abnormal_bone_mineralization0.69823023
135MP0002127_abnormal_cardiovascular_syste0.69692457
136MP0005023_abnormal_wound_healing0.69511504
137MP0003890_abnormal_embryonic-extraembry0.68879215
138MP0005025_abnormal_response_to0.68045465
139MP0000750_abnormal_muscle_regeneration0.67215434
140MP0005451_abnormal_body_composition0.67054541
141MP0000749_muscle_degeneration0.66991676
142MP0000733_abnormal_muscle_development0.64049090
143MP0010030_abnormal_orbit_morphology0.61208335
144MP0004808_abnormal_hematopoietic_stem0.60452405
145MP0001293_anophthalmia0.59956255
146MP0003795_abnormal_bone_structure0.58543641
147MP0002972_abnormal_cardiac_muscle0.57045631
148MP0002108_abnormal_muscle_morphology0.56477169
149MP0001243_abnormal_dermal_layer0.55317539
150MP0004947_skin_inflammation0.54478562
151MP0008469_abnormal_protein_level0.52946278
152MP0005397_hematopoietic_system_phenotyp0.51510028

Predicted human phenotypes

RankGene SetZ-score
1Axonal loss (HP:0003447)6.74450515
2Protrusio acetabuli (HP:0003179)5.41565790
3Spontaneous hematomas (HP:0007420)5.01592157
4Milia (HP:0001056)4.73552096
5Disinhibition (HP:0000734)4.57529758
6Thick nail (HP:0001805)4.57221580
7Prolonged partial thromboplastin time (HP:0003645)4.49087533
8Abnormality of the vasculature of the conjunctiva (HP:0008054)4.40368249
9Premature rupture of membranes (HP:0001788)4.33467128
10Polycythemia (HP:0001901)4.23317450
11Hematochezia (HP:0002573)4.22369141
12Dysostosis multiplex (HP:0000943)4.19447181
13Arterial tortuosity (HP:0005116)3.96720272
14Cervical subluxation (HP:0003308)3.81461764
15Conjunctival telangiectasia (HP:0000524)3.76634858
16Broad ribs (HP:0000885)3.67668870
17Atrophic scars (HP:0001075)3.60164638
18Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.58417722
19Vascular tortuosity (HP:0004948)3.57686571
20Stenosis of the external auditory canal (HP:0000402)3.57445201
21Systemic lupus erythematosus (HP:0002725)3.56014616
22Abnormality of liposaccharide metabolism (HP:0010968)3.55939680
23Abnormality of glycosphingolipid metabolism (HP:0004343)3.55939680
24Abnormality of glycolipid metabolism (HP:0010969)3.55939680
25Cerebral hemorrhage (HP:0001342)3.52736302
26Agnosia (HP:0010524)3.51545108
27Facial hemangioma (HP:0000329)3.49920986
28Rectal prolapse (HP:0002035)3.46880282
29Wrist flexion contracture (HP:0001239)3.32904460
30Abnormality of the nasal mucosa (HP:0000433)3.31031902
31Cerebral aneurysm (HP:0004944)3.26150336
32Termporal pattern (HP:0011008)3.22882901
33Insidious onset (HP:0003587)3.22882901
34Aortic valve stenosis (HP:0001650)3.21942467
35Spinal rigidity (HP:0003306)3.17940961
36Abnormal platelet function (HP:0011869)3.08449488
37Impaired platelet aggregation (HP:0003540)3.08449488
38Inappropriate behavior (HP:0000719)3.06256790
39Lip pit (HP:0100267)2.96236920
40Mucosal telangiectasiae (HP:0100579)2.95224471
41Joint hemorrhage (HP:0005261)2.95087547
42Thickened calvaria (HP:0002684)2.93130670
43Upper motor neuron abnormality (HP:0002127)2.89288073
44Urinary glycosaminoglycan excretion (HP:0003541)2.88720136
45Mucopolysacchariduria (HP:0008155)2.88720136
46Vacuolated lymphocytes (HP:0001922)2.88069766
47Abnormality of the nasal septum (HP:0000419)2.86789652
48Disproportionate tall stature (HP:0001519)2.85885235
49Abnormality of the intrinsic pathway (HP:0010989)2.83084847
50Colitis (HP:0002583)2.73294935
51Portal hypertension (HP:0001409)2.72733706
52Glomerulonephritis (HP:0000099)2.71024900
53Tetraparesis (HP:0002273)2.69169965
54Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64604328
55Abnormality of polysaccharide metabolism (HP:0011012)2.64604328
56Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64604328
57Plantar hyperkeratosis (HP:0007556)2.64537417
58Visual hallucinations (HP:0002367)2.64174689
59Focal seizures (HP:0007359)2.62652841
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.59708260
61Recurrent abscess formation (HP:0002722)2.59427811
62Overgrowth (HP:0001548)2.59071491
63Mitral valve prolapse (HP:0001634)2.58573132
64Skull defect (HP:0001362)2.56470211
65Osteolytic defects of the hand bones (HP:0009699)2.55323220
66Osteolytic defects of the phalanges of the hand (HP:0009771)2.55323220
67Asymmetric septal hypertrophy (HP:0001670)2.53116158
68Hypertensive crisis (HP:0100735)2.49964545
69Vertebral arch anomaly (HP:0008438)2.49275894
70Atonic seizures (HP:0010819)2.48974583
71Wormian bones (HP:0002645)2.47801112
72Abnormality of the hepatic vasculature (HP:0006707)2.45191339
73Complement deficiency (HP:0004431)2.44629718
74Flexion contracture of toe (HP:0005830)2.44342493
75Joint contractures involving the joints of the feet (HP:0100492)2.44342493
76Inflammation of the large intestine (HP:0002037)2.43281624
77Neurofibrillary tangles (HP:0002185)2.42140631
78Increased cerebral lipofuscin (HP:0011813)2.39387652
79Nonimmune hydrops fetalis (HP:0001790)2.35993157
80Apathy (HP:0000741)2.32372880
81Dialeptic seizures (HP:0011146)2.31136371
82Menorrhagia (HP:0000132)2.30949531
83Neonatal death (HP:0003811)2.30109928
84Peripheral demyelination (HP:0011096)2.28507882
85Vertebral compression fractures (HP:0002953)2.27890539
86Aortic dissection (HP:0002647)2.26634653
87Pulmonary hypertension (HP:0002092)2.26431191
88Blue sclerae (HP:0000592)2.25412608
89Craniofacial hyperostosis (HP:0004493)2.21121306
90Epistaxis (HP:0000421)2.20499698
91Pustule (HP:0200039)2.19408003
92Cerebral inclusion bodies (HP:0100314)2.19016725
93Joint stiffness (HP:0001387)2.17846264
94Adactyly (HP:0009776)2.17467838
95Xerostomia (HP:0000217)2.16780581
96Reduced subcutaneous adipose tissue (HP:0003758)2.16290106
97Focal motor seizures (HP:0011153)2.16007152
98Aortic aneurysm (HP:0004942)2.14494298
99Esophageal varix (HP:0002040)2.13919699
100Palmoplantar hyperkeratosis (HP:0000972)2.13819008
101Aneurysm (HP:0002617)2.13077892
102Subcapsular cataract (HP:0000523)2.12082698
103Onycholysis (HP:0001806)2.12048521
104Diminished motivation (HP:0000745)2.11918271
105Camptodactyly of toe (HP:0001836)2.11900545
106Aplasia cutis congenita (HP:0001057)2.10182875
107Torticollis (HP:0000473)2.10010296
108Gastrointestinal inflammation (HP:0004386)2.07962520
109Scanning speech (HP:0002168)2.07583176
110Ectopia lentis (HP:0001083)2.01854165
111Dilatation of the ascending aorta (HP:0005111)2.00929362
112Abnormality of the common coagulation pathway (HP:0010990)2.00479116
113Short nail (HP:0001799)1.99612807
114Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.99327906
115Thoracolumbar scoliosis (HP:0002944)1.97231726
116Glossoptosis (HP:0000162)1.96708869
117Peripheral hypomyelination (HP:0007182)1.96089912
118Spondylolisthesis (HP:0003302)1.94691027
119Exotropia (HP:0000577)1.93640105
120Posterior subcapsular cataract (HP:0007787)1.93423479
121Absent hand (HP:0004050)1.92584486
122Status epilepticus (HP:0002133)1.92576523
123Epileptic encephalopathy (HP:0200134)1.92511356
124Prolonged bleeding time (HP:0003010)1.92429881
125Bifid uvula (HP:0000193)1.92079712
126Ovoid vertebral bodies (HP:0003300)1.91654331
127Abnormality of complement system (HP:0005339)1.91050118
128Distal lower limb amyotrophy (HP:0008944)1.90813919
129Capillary hemangiomas (HP:0005306)1.90359434
130Abnormality of the alveolar ridges (HP:0006477)1.90280210
131Basal ganglia calcification (HP:0002135)1.90075107
132Arthropathy (HP:0003040)1.89776269
133Soft skin (HP:0000977)1.88925438
134Bone pain (HP:0002653)1.88924913
135Nuclear cataract (HP:0100018)1.87810870
136Upper limb amyotrophy (HP:0009129)1.86404444
137Distal upper limb amyotrophy (HP:0007149)1.86404444
138Palmar hyperkeratosis (HP:0010765)1.86039016
139Papilledema (HP:0001085)1.86032811
140Coxa vara (HP:0002812)1.85466107
141Abnormality of the acetabulum (HP:0003170)1.85084476
142Porencephaly (HP:0002132)1.84912206
143Visceral angiomatosis (HP:0100761)1.84739174
144Macroorchidism (HP:0000053)1.83737877
145Recurrent corneal erosions (HP:0000495)1.83568770
146Nephritis (HP:0000123)1.83112651
147Broad alveolar ridges (HP:0000187)1.82086163
148Abnormality of proline metabolism (HP:0010907)1.81806143
149Hydroxyprolinuria (HP:0003080)1.81806143
150Eczematoid dermatitis (HP:0000976)1.81788240
151Myocardial infarction (HP:0001658)1.81193086
152Pulmonary infiltrates (HP:0002113)1.80898950
153Spontaneous abortion (HP:0005268)1.80709016
154Glucose intolerance (HP:0000833)1.80543107
155Bladder diverticulum (HP:0000015)1.80336452
156Broad face (HP:0000283)1.80194291
157Hemangiomatosis (HP:0007461)1.80093599
158Orthostatic hypotension (HP:0001278)1.78336124
159Mitral regurgitation (HP:0001653)1.78187901
160Cavernous hemangioma (HP:0001048)1.78166279
161Colon cancer (HP:0003003)1.78139579
162Hypoplasia of dental enamel (HP:0006297)1.75379086
163Obstructive sleep apnea (HP:0002870)1.75072850
164Ankle contracture (HP:0006466)1.74900150
165Hamartoma (HP:0010566)1.74444247
166Absence seizures (HP:0002121)1.73554953
167Distal lower limb muscle weakness (HP:0009053)1.72557438
168Coxa valga (HP:0002673)1.72264940
169Chondrocalcinosis (HP:0000934)1.71702066
170Natal tooth (HP:0000695)1.69881683
171Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.67958611
172Cranial hyperostosis (HP:0004437)1.67876320
173Personality changes (HP:0000751)1.67416951

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE19.79432206
2TGFBR24.46263593
3WNK33.45239317
4DDR22.39984607
5SCYL22.33429243
6FES2.18663691
7TGFBR12.08220678
8PDGFRA2.04340362
9BLK10.3430920
10MAP2K21.97744281
11MELK1.92609555
12SIK31.92458218
13IRAK11.91456293
14TEC1.88521962
15ACVR1B1.77270536
16MYLK1.75371176
17NLK1.75039253
18RIPK11.66374207
19ERBB41.61589911
20IRAK21.58106472
21CASK1.55980824
22MAP3K121.53260665
23FGR1.44866759
24TRIM281.43430440
25NTRK31.42526565
26DMPK1.40594804
27PAK41.38548558
28NEK91.31011493
29MET1.30015918
30SIK21.26903863
31MAP2K31.24873212
32MKNK21.20235839
33LATS21.16364897
34TBK11.15282590
35PIM21.12886989
36JAK31.10212711
37NUAK11.09371893
38ZAP701.09315703
39MOS1.08793262
40IRAK31.08517290
41PAK21.04367405
42MAPK151.03745208
43PLK21.00470018
44GRK70.97961644
45MAP3K140.97793382
46LIMK10.97787608
47TRPM70.96939661
48BMX0.96881711
49TYK20.96122263
50FLT30.90483150
51PAK60.90170220
52CSF1R0.89348360
53NTRK20.87819178
54PDGFRB0.87045262
55ITK0.86905014
56MINK10.85507692
57STK110.85272818
58RIPK40.83926645
59NTRK10.82243811
60EPHA40.81855861
61PKN10.81299929
62PIK3CA0.80972582
63TAOK20.80739412
64KSR10.78866692
65LATS10.77978959
66PRKG20.76864082
67PRKCQ0.76633364
68PRKD20.74758162
69BRD40.74458474
70STK100.73481423
71TSSK60.73420557
72ADRBK10.72666747
73CAMK2A0.71258529
74EPHA20.70618446
75FYN0.68514264
76MAP3K40.67013766
77CDK80.66838520
78HIPK20.65685216
79MAP3K110.64046132
80DAPK20.63757391
81TTN0.63455112
82STK390.61565676
83LYN0.61314151
84PTK2B0.60054468
85BMPR20.58678966
86TESK10.56305150
87GRK50.56139832
88EPHB10.55827836
89ICK0.55750079
90CDK50.55516278
91ROCK10.55435804
92PRKCG0.55387944
93CAMK2D0.54373797
94MAPK130.54222475
95MAP2K40.54037378
96TNIK0.53483098
97PRKD10.52922805
98GSK3A0.50325266
99STK380.49793135
100KDR0.49652454
101DAPK30.49545934
102CDC42BPA0.49388150
103LRRK20.49005493
104IKBKE0.48146535
105MAPK40.48109355
106MATK0.47848334
107WNK40.47764644
108FGFR30.47191086
109CDK90.46546067
110HCK0.45269332
111ROCK20.44924277
112UHMK10.44086618
113BTK0.43985964
114INSR0.43656216
115FER0.43302135
116CDK60.42996475
117JAK10.42962868
118FGFR40.42090550
119EGFR0.41952697
120MAPK70.41940673
121PDK10.41916625
122RPS6KA20.41344256
123SYK0.41088557
124PRKCH0.40846032
125MARK10.39879259
126ERBB20.39529130
127MAP2K70.39310063
128ERN10.39252885
129CSK0.39111721
130MKNK10.38734137
131MARK20.38049392
132MST1R0.37870865
133PRKCD0.37827207
134MAPK120.37543734
135PRKCE0.37233259
136PRKG10.37167997
137MAP3K30.35795024
138ABL10.35145090
139PRKCB0.34845336
140PAK30.34582568
141CAMK2B0.34441474
142ADRBK20.34053018
143SRC0.33870607
144PRKD30.32828752
145IGF1R0.32457273
146CHUK0.32217171
147BCR0.31926096
148IKBKB0.31593788
149EPHB20.30869065
150ABL20.30830011
151EIF2AK10.30799617
152FGFR10.30382526
153PTK20.30374865
154MAPK90.30309987
155MAP3K50.28790848
156PTK60.25741022
157ERBB30.22291909
158CLK10.21050045
159PDPK10.20650664
160MAP3K10.19832736

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.41275726
2Malaria_Homo sapiens_hsa051442.31235500
3Complement and coagulation cascades_Homo sapiens_hsa046102.25874703
4RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05112849
5African trypanosomiasis_Homo sapiens_hsa051432.01711752
6Toll-like receptor signaling pathway_Homo sapiens_hsa046201.85865453
7Osteoclast differentiation_Homo sapiens_hsa043801.80094985
8TNF signaling pathway_Homo sapiens_hsa046681.80006422
9Bladder cancer_Homo sapiens_hsa052191.74761484
10Nicotine addiction_Homo sapiens_hsa050331.68872098
11Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66814927
12Shigellosis_Homo sapiens_hsa051311.59281134
13Dilated cardiomyopathy_Homo sapiens_hsa054141.58086681
14Other glycan degradation_Homo sapiens_hsa005111.55101238
15Salivary secretion_Homo sapiens_hsa049701.54334742
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.51134761
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.45471018
18Small cell lung cancer_Homo sapiens_hsa052221.44748672
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42191836
20Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.40659114
21Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38216890
22Renin secretion_Homo sapiens_hsa049241.37060064
23Phagosome_Homo sapiens_hsa041451.35440746
24B cell receptor signaling pathway_Homo sapiens_hsa046621.31960131
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.31648257
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30888141
27Amoebiasis_Homo sapiens_hsa051461.30733263
28Calcium signaling pathway_Homo sapiens_hsa040201.30143645
29Lysosome_Homo sapiens_hsa041421.29681592
30Influenza A_Homo sapiens_hsa051641.28091308
31Taste transduction_Homo sapiens_hsa047421.27361939
32Long-term potentiation_Homo sapiens_hsa047201.26069815
33Prion diseases_Homo sapiens_hsa050201.25281847
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24970472
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.21218081
36GABAergic synapse_Homo sapiens_hsa047271.20521968
37Oxytocin signaling pathway_Homo sapiens_hsa049211.19194484
38Morphine addiction_Homo sapiens_hsa050321.18880487
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.18677585
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18479191
41Hepatitis C_Homo sapiens_hsa051601.17463099
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.16583706
43Rheumatoid arthritis_Homo sapiens_hsa053231.16555005
44ECM-receptor interaction_Homo sapiens_hsa045121.16477274
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.15837297
46PI3K-Akt signaling pathway_Homo sapiens_hsa041511.15310892
47* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14903419
48Measles_Homo sapiens_hsa051621.14731311
49Glutamatergic synapse_Homo sapiens_hsa047241.14672819
50Tuberculosis_Homo sapiens_hsa051521.13154092
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12417939
52Hepatitis B_Homo sapiens_hsa051611.09818250
53Salmonella infection_Homo sapiens_hsa051321.08175179
54Chronic myeloid leukemia_Homo sapiens_hsa052201.08145170
55Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08043241
56Axon guidance_Homo sapiens_hsa043601.06267090
57Platelet activation_Homo sapiens_hsa046111.05536229
58Circadian entrainment_Homo sapiens_hsa047131.04755436
59Nitrogen metabolism_Homo sapiens_hsa009101.04444493
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04026370
61Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.99145871
62cAMP signaling pathway_Homo sapiens_hsa040240.99072793
63Pathways in cancer_Homo sapiens_hsa052000.94438707
64Olfactory transduction_Homo sapiens_hsa047400.93737898
65Primary bile acid biosynthesis_Homo sapiens_hsa001200.91956651
66Vibrio cholerae infection_Homo sapiens_hsa051100.91562449
67Dorso-ventral axis formation_Homo sapiens_hsa043200.91104377
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90705024
69Chemokine signaling pathway_Homo sapiens_hsa040620.90254296
70Type II diabetes mellitus_Homo sapiens_hsa049300.89764368
71Focal adhesion_Homo sapiens_hsa045100.89221633
72HIF-1 signaling pathway_Homo sapiens_hsa040660.89020014
73Synaptic vesicle cycle_Homo sapiens_hsa047210.88599146
74Insulin secretion_Homo sapiens_hsa049110.86787722
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86071871
76Toxoplasmosis_Homo sapiens_hsa051450.85946987
77Amphetamine addiction_Homo sapiens_hsa050310.85715320
78Arachidonic acid metabolism_Homo sapiens_hsa005900.85397029
79Jak-STAT signaling pathway_Homo sapiens_hsa046300.85135845
80Sphingolipid metabolism_Homo sapiens_hsa006000.85106009
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84592777
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83791964
83Sulfur metabolism_Homo sapiens_hsa009200.83659063
84Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.83104818
85Cholinergic synapse_Homo sapiens_hsa047250.82927396
86Pancreatic secretion_Homo sapiens_hsa049720.82590014
87p53 signaling pathway_Homo sapiens_hsa041150.81925074
88Serotonergic synapse_Homo sapiens_hsa047260.81822241
89VEGF signaling pathway_Homo sapiens_hsa043700.80975743
90Viral myocarditis_Homo sapiens_hsa054160.80602654
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.80598636
92ErbB signaling pathway_Homo sapiens_hsa040120.80485536
93Sphingolipid signaling pathway_Homo sapiens_hsa040710.79627778
94MicroRNAs in cancer_Homo sapiens_hsa052060.78695390
95Gastric acid secretion_Homo sapiens_hsa049710.78405049
96Asthma_Homo sapiens_hsa053100.76490209
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74664694
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74375686
99Legionellosis_Homo sapiens_hsa051340.74321112
100Rap1 signaling pathway_Homo sapiens_hsa040150.74236309
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72954565
102Hedgehog signaling pathway_Homo sapiens_hsa043400.71944777
103Bile secretion_Homo sapiens_hsa049760.71720299
104Hematopoietic cell lineage_Homo sapiens_hsa046400.71659643
105Endocytosis_Homo sapiens_hsa041440.70762776
106Melanoma_Homo sapiens_hsa052180.70558943
107Hippo signaling pathway_Homo sapiens_hsa043900.70406213
108Long-term depression_Homo sapiens_hsa047300.70196486
109TGF-beta signaling pathway_Homo sapiens_hsa043500.69467711
110GnRH signaling pathway_Homo sapiens_hsa049120.69426113
111MAPK signaling pathway_Homo sapiens_hsa040100.69028024
112Ras signaling pathway_Homo sapiens_hsa040140.68901503
113SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68712855
114Leishmaniasis_Homo sapiens_hsa051400.68448432
115Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66639062
116Apoptosis_Homo sapiens_hsa042100.65482401
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65446273
118Colorectal cancer_Homo sapiens_hsa052100.64465663
119Pertussis_Homo sapiens_hsa051330.64160107
120Cocaine addiction_Homo sapiens_hsa050300.63586782
121ABC transporters_Homo sapiens_hsa020100.63064855
122Glioma_Homo sapiens_hsa052140.62528334
123Basal cell carcinoma_Homo sapiens_hsa052170.62508061
124Adherens junction_Homo sapiens_hsa045200.62188169
125NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62164931
126Arginine biosynthesis_Homo sapiens_hsa002200.61076037
127Dopaminergic synapse_Homo sapiens_hsa047280.60629798
128Proteoglycans in cancer_Homo sapiens_hsa052050.58391014
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57198298
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.57120516
131Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56523499
132Pancreatic cancer_Homo sapiens_hsa052120.54769633
133Prolactin signaling pathway_Homo sapiens_hsa049170.54666004
134Neurotrophin signaling pathway_Homo sapiens_hsa047220.54598370
135Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52659555
136Gap junction_Homo sapiens_hsa045400.52533842
137Estrogen signaling pathway_Homo sapiens_hsa049150.52145462
138Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.49797218
139Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49790592
140Renal cell carcinoma_Homo sapiens_hsa052110.49166737
141Tight junction_Homo sapiens_hsa045300.49081513
142Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46765481
143Wnt signaling pathway_Homo sapiens_hsa043100.46734391
144Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.46584840
145Thyroid hormone synthesis_Homo sapiens_hsa049180.46501737
146Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46070945
147Melanogenesis_Homo sapiens_hsa049160.42341108
148Herpes simplex infection_Homo sapiens_hsa051680.41450831
149Protein digestion and absorption_Homo sapiens_hsa049740.39593583
150Allograft rejection_Homo sapiens_hsa053300.38908471
151HTLV-I infection_Homo sapiens_hsa051660.38899362
152Notch signaling pathway_Homo sapiens_hsa043300.38444140
153Prostate cancer_Homo sapiens_hsa052150.36182206

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