TNFSF14

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of isotype switching to IgG isotypes (GO:0048302)6.74149297
2positive regulation of isotype switching (GO:0045830)5.71128847
3regulation of interleukin-12 biosynthetic process (GO:0045075)5.55520518
4regulation of regulatory T cell differentiation (GO:0045589)5.39561372
5positive regulation of gamma-delta T cell activation (GO:0046645)5.38398966
6positive regulation of B cell mediated immunity (GO:0002714)5.35694857
7positive regulation of immunoglobulin mediated immune response (GO:0002891)5.35694857
8regulation of immunoglobulin secretion (GO:0051023)5.30409535
9regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.27137998
10positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)5.20103234
11antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.02650866
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.02650866
13positive regulation of DNA recombination (GO:0045911)4.84219601
14regulation of gamma-delta T cell differentiation (GO:0045586)4.76869458
15response to interleukin-15 (GO:0070672)4.55129800
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.48172376
17positive regulation by organism of defense response of other organism involved in symbiotic interact4.48172376
18modulation by symbiont of host immune response (GO:0052553)4.48172376
19positive regulation by symbiont of host defense response (GO:0052509)4.48172376
20modulation by symbiont of host defense response (GO:0052031)4.48172376
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.48172376
22regulation of immunoglobulin mediated immune response (GO:0002889)4.46868127
23cellular response to interleukin-15 (GO:0071350)4.46548625
24regulation of B cell receptor signaling pathway (GO:0050855)4.45502724
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.44964736
26leukocyte aggregation (GO:0070486)4.44555160
27regulation of B cell mediated immunity (GO:0002712)4.43550144
28regulation of gamma-delta T cell activation (GO:0046643)4.42683434
29regulation of isotype switching (GO:0045191)4.40738222
30regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)4.26596358
31interferon-gamma production (GO:0032609)4.18549290
32antigen processing and presentation of endogenous antigen (GO:0019883)4.15961042
33positive regulation of interleukin-17 production (GO:0032740)4.09524154
34positive regulation of immunoglobulin production (GO:0002639)4.09003316
35regulation of immunoglobulin production (GO:0002637)4.03147498
36negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.02510592
37negative regulation of cell killing (GO:0031342)4.02510592
38negative T cell selection (GO:0043383)3.99438895
39negative regulation of B cell apoptotic process (GO:0002903)3.98402445
40positive regulation of humoral immune response (GO:0002922)3.96278142
41NIK/NF-kappaB signaling (GO:0038061)3.95218398
42negative thymic T cell selection (GO:0045060)3.93173485
43antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.84422952
44defense response to protozoan (GO:0042832)3.83691310
45macrophage activation involved in immune response (GO:0002281)3.80681194
46regulation of interferon-beta biosynthetic process (GO:0045357)3.76772413
47myeloid dendritic cell differentiation (GO:0043011)3.75080022
48positive thymic T cell selection (GO:0045059)3.73831768
49myeloid dendritic cell activation (GO:0001773)3.71411802
50response to protozoan (GO:0001562)3.69802541
51regulation of vitamin D biosynthetic process (GO:0060556)3.65926247
52tyrosine phosphorylation of STAT protein (GO:0007260)3.62192864
53response to peptidoglycan (GO:0032494)3.57581606
54regulation of T cell tolerance induction (GO:0002664)3.57147909
55neutrophil activation involved in immune response (GO:0002283)3.55437207
56regulation of interleukin-17 production (GO:0032660)3.54934157
57detection of other organism (GO:0098543)3.52021114
58detection of biotic stimulus (GO:0009595)3.50126686
59detection of molecule of bacterial origin (GO:0032490)3.49714077
60neutrophil mediated immunity (GO:0002446)3.47989162
61CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.41676341
62positive regulation of lymphocyte mediated immunity (GO:0002708)3.41531215
63regulation of alpha-beta T cell proliferation (GO:0046640)3.41193750
64neutrophil activation (GO:0042119)3.38992891
65positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.38798610
66negative regulation of T cell mediated immunity (GO:0002710)3.34757243
67granulocyte activation (GO:0036230)3.32067059
68detection of bacterium (GO:0016045)3.29483233
69positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.27671097
70detection of external biotic stimulus (GO:0098581)3.26716194
71positive regulation of macrophage differentiation (GO:0045651)3.24063523
72regulation of tolerance induction (GO:0002643)3.22658914
73positive regulation of alpha-beta T cell proliferation (GO:0046641)3.22263480
74regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.22189565
75regulation of natural killer cell mediated immunity (GO:0002715)3.22189565
76regulation of vitamin metabolic process (GO:0030656)3.21107271
77negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.20484736
78activated T cell proliferation (GO:0050798)3.20179113
79natural killer cell activation (GO:0030101)3.20170358
80positive regulation of T cell mediated cytotoxicity (GO:0001916)3.19236642
81negative regulation of leukocyte mediated immunity (GO:0002704)3.18645505
82positive regulation of natural killer cell mediated immunity (GO:0002717)3.18631730
83positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.18631730
84positive regulation of mast cell activation (GO:0033005)3.18146998
85regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.17065224
86regulation of lymphocyte mediated immunity (GO:0002706)3.14616641
87response to type I interferon (GO:0034340)3.13794498
88cellular response to type I interferon (GO:0071357)3.13646896
89type I interferon signaling pathway (GO:0060337)3.13646896
90positive regulation of activated T cell proliferation (GO:0042104)3.13154024
91positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.11954016
92positive T cell selection (GO:0043368)3.11791484
93positive regulation of tolerance induction (GO:0002645)3.10622510
94myeloid cell activation involved in immune response (GO:0002275)3.10520158
95response to host immune response (GO:0052572)3.09205483
96response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.09205483
97positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.09068790
98mast cell activation (GO:0045576)3.09014663
99positive regulation of cell killing (GO:0031343)3.08232624
100regulation of leukocyte mediated cytotoxicity (GO:0001910)3.07511075
101ribosomal small subunit assembly (GO:0000028)3.06666497
102regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.06662990
103antigen processing and presentation via MHC class Ib (GO:0002475)3.06278474
104regulation of T cell mediated cytotoxicity (GO:0001914)3.05952695
105positive regulation of adaptive immune response based on somatic recombination of immune receptors b3.05794742
106T cell migration (GO:0072678)3.05789372
107positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.05743027
108regulation of interleukin-2 biosynthetic process (GO:0045076)3.05065942
109respiratory burst (GO:0045730)3.04629833
110regulation of chronic inflammatory response (GO:0002676)3.04304689
111regulation of B cell apoptotic process (GO:0002902)3.04136203
112microglial cell activation (GO:0001774)3.03602915
113positive regulation of leukocyte mediated immunity (GO:0002705)3.02588576
114immunoglobulin mediated immune response (GO:0016064)3.02246719
115positive regulation of B cell differentiation (GO:0045579)3.02033791
116regulation of podosome assembly (GO:0071801)3.01788189
117thymic T cell selection (GO:0045061)3.01718644
118regulation of response to interferon-gamma (GO:0060330)3.00908010
119cellular extravasation (GO:0045123)3.00690965
120regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.00585520
121regulation of B cell differentiation (GO:0045577)3.00393292
122positive regulation of chemokine biosynthetic process (GO:0045080)2.99857362
123regulation of mast cell activation (GO:0033003)2.99820216
124regulation of cell killing (GO:0031341)2.99293031
125tolerance induction (GO:0002507)2.99127278
126regulation of T cell receptor signaling pathway (GO:0050856)2.98408394
127T cell receptor signaling pathway (GO:0050852)2.98063630
128negative regulation of interleukin-12 production (GO:0032695)2.97096557
129myeloid leukocyte mediated immunity (GO:0002444)2.97047556
130negative regulation of cytokine production involved in immune response (GO:0002719)2.96091323
131negative regulation of lymphocyte mediated immunity (GO:0002707)2.94696403
132lipopolysaccharide-mediated signaling pathway (GO:0031663)2.94343694
133positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.93899617
134regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.93899617
135JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.93201459
136regulation of growth of symbiont in host (GO:0044126)2.93066404
137negative regulation of growth of symbiont in host (GO:0044130)2.93066404
138negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.93066404
139modulation of growth of symbiont involved in interaction with host (GO:0044144)2.93066404
140positive regulation of interferon-gamma production (GO:0032729)2.92892703
141germinal center formation (GO:0002467)2.92166945
142macrophage activation (GO:0042116)2.86249304
143negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.85272318
144myeloid leukocyte activation (GO:0002274)2.83512108
145necroptotic process (GO:0070266)2.83164098
146interferon-gamma-mediated signaling pathway (GO:0060333)2.82673412
147positive regulation of interleukin-10 production (GO:0032733)2.82525530
148leukocyte degranulation (GO:0043299)2.81935989
149production of molecular mediator involved in inflammatory response (GO:0002532)2.81534537
150negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80518600
151negative regulation of T-helper cell differentiation (GO:0045623)2.80518600

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.15614215
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.93689029
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.70977045
4E2F7_22180533_ChIP-Seq_HELA_Human4.11544502
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.81103514
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.47293602
7* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.33601666
8* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.26720615
9IRF8_21731497_ChIP-ChIP_J774_Mouse3.22978808
10STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.17558941
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.15748371
12MYC_22102868_ChIP-Seq_BL_Human3.14405987
13NOTCH1_21737748_ChIP-Seq_TLL_Human3.14323105
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.87230323
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.84520001
16SCL_19346495_ChIP-Seq_HPC-7_Human2.76014346
17RUNX_20019798_ChIP-Seq_JUKART_Human2.72779415
18* MYB_26560356_Chip-Seq_TH2_Human2.64483053
19* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.62080017
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56989148
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.48006569
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.42993094
23* MAF_26560356_Chip-Seq_TH1_Human2.42430952
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.38557120
25VDR_21846776_ChIP-Seq_THP-1_Human2.31204385
26* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29790236
27MYB_26560356_Chip-Seq_TH1_Human2.27639190
28* SPI1_23547873_ChIP-Seq_NB4_Human2.27003680
29EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25236637
30UTX_26944678_Chip-Seq_JUKART_Human2.17547631
31IRF8_27001747_Chip-Seq_BMDM_Mouse2.17491646
32RUNX1_22412390_ChIP-Seq_EML_Mouse2.06748286
33* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.93085815
34VDR_24787735_ChIP-Seq_THP-1_Human1.92493511
35TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91388721
36VDR_24763502_ChIP-Seq_THP-1_Human1.91231067
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.86588300
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.86437079
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86351492
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84415837
41TCF7_22412390_ChIP-Seq_EML_Mouse1.82796312
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.75963835
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.73552795
44NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.69997848
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.69220004
46MAF_26560356_Chip-Seq_TH2_Human1.69199878
47MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.66500281
48GATA3_27048872_Chip-Seq_THYMUS_Human1.63930032
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.63380188
50SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60955475
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58247359
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.54175920
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53982748
54KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.48981170
55* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.43367143
56KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.42759156
57* EGR1_23403033_ChIP-Seq_LIVER_Mouse1.42213781
58SPI1_23127762_ChIP-Seq_K562_Human1.39460046
59CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39056033
60GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.38843743
61HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37161602
62VDR_23849224_ChIP-Seq_CD4+_Human1.36461050
63GATA2_22383799_ChIP-Seq_G1ME_Mouse1.35435528
64PU_27001747_Chip-Seq_BMDM_Mouse1.35024855
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.34423065
66CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23465970
67TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21728897
68GATA3_26560356_Chip-Seq_TH2_Human1.21440685
69* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21430025
70* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.20222929
71LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.17981104
72KDM2B_26808549_Chip-Seq_DND41_Human1.17429678
73BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.16160953
74CIITA_25753668_ChIP-Seq_RAJI_Human1.15750625
75CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14374124
76FOXP3_21729870_ChIP-Seq_TREG_Human1.14341530
77IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11899979
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.10564165
79* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10443548
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09287793
81RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.08406894
82E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08123302
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.08067362
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.05928457
85VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05295777
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03574777
87* ELK3_25401928_ChIP-Seq_HUVEC_Human1.02406047
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01736662
89PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01083531
90GABP_17652178_ChIP-ChIP_JURKAT_Human1.00759256
91PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00589211
92SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99507200
93SMRT_27268052_Chip-Seq_Bcells_Human0.98923023
94BCL6_27268052_Chip-Seq_Bcells_Human0.97576541
95CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97540943
96GATA1_19941827_ChIP-Seq_MEL_Mouse0.97413738
97MYC_19079543_ChIP-ChIP_MESCs_Mouse0.97233303
98GATA2_21666600_ChIP-Seq_HMVEC_Human0.95510884
99NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95335666
100GATA1_22025678_ChIP-Seq_K562_Human0.94373808
101MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93651553
102PU.1_20513432_ChIP-Seq_Bcells_Mouse0.92133096
103EST1_17652178_ChIP-ChIP_JURKAT_Human0.91812499
104EGR1_19032775_ChIP-ChIP_M12_Human0.91613352
105ELK1_19687146_ChIP-ChIP_HELA_Human0.89683318
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.89188599
107FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.89168101
108RXR_22158963_ChIP-Seq_LIVER_Mouse0.88757155
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88747738
110SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87519386
111CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87051594
112GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85398122
113LXR_22158963_ChIP-Seq_LIVER_Mouse0.85216753
114MYC_19030024_ChIP-ChIP_MESCs_Mouse0.84721432
115NCOR1_26117541_ChIP-Seq_K562_Human0.84643006
116* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84610924
117XRN2_22483619_ChIP-Seq_HELA_Human0.84363028
118GATA3_26560356_Chip-Seq_TH1_Human0.84028762
119ZNF274_21170338_ChIP-Seq_K562_Hela0.83159373
120SPI1_20517297_ChIP-Seq_HL60_Human0.80935280
121* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80598565
122STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80085460
123RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.80055958
124E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.79999156
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.79546904
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79399467
127BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.79146135
128EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79011290
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78309653
130GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74911544
131ETS1_22383799_ChIP-Seq_G1ME_Mouse0.74697040
132BCOR_27268052_Chip-Seq_Bcells_Human0.74684363
133* EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74481910

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.45310536
2* MP0005671_abnormal_response_to3.80035808
3MP0003436_decreased_susceptibility_to3.68981515
4MP0000685_abnormal_immune_system3.65082325
5MP0003300_gastrointestinal_ulcer3.56901222
6MP0009785_altered_susceptibility_to3.52199917
7MP0003763_abnormal_thymus_physiology3.49861096
8MP0001853_heart_inflammation3.02473268
9MP0002396_abnormal_hematopoietic_system2.96620804
10MP0005000_abnormal_immune_tolerance2.91166957
11MP0001800_abnormal_humoral_immune2.84796906
12MP0002405_respiratory_system_inflammati2.76380283
13MP0000465_gastrointestinal_hemorrhage2.75696838
14MP0005025_abnormal_response_to2.75412629
15MP0005387_immune_system_phenotype2.59315656
16MP0001790_abnormal_immune_system2.59315656
17MP0003303_peritoneal_inflammation2.56482029
18* MP0002723_abnormal_immune_serum2.55404423
19MP0003724_increased_susceptibility_to2.51828230
20* MP0002420_abnormal_adaptive_immunity2.49434333
21* MP0001819_abnormal_immune_cell2.46104870
22MP0002452_abnormal_antigen_presenting2.44715674
23* MP0002398_abnormal_bone_marrow2.41984934
24MP0006082_CNS_inflammation2.35723342
25MP0002148_abnormal_hypersensitivity_rea2.35677624
26MP0002139_abnormal_hepatobiliary_system2.35024061
27MP0002419_abnormal_innate_immunity2.33415025
28MP0002166_altered_tumor_susceptibility2.28488786
29MP0004808_abnormal_hematopoietic_stem2.17795944
30MP0001873_stomach_inflammation2.12033229
31MP0010155_abnormal_intestine_physiology2.10013457
32* MP0000716_abnormal_immune_system2.08827738
33* MP0009333_abnormal_splenocyte_physiolog2.06027882
34MP0005464_abnormal_platelet_physiology2.05263763
35MP0000689_abnormal_spleen_morphology2.03364728
36MP0003866_abnormal_defecation2.00617360
37MP0002722_abnormal_immune_system1.98809219
38MP0000604_amyloidosis1.94802914
39MP0002006_tumorigenesis1.94160690
40MP0004510_myositis1.93934837
41MP0002138_abnormal_hepatobiliary_system1.93340229
42MP0003191_abnormal_cellular_cholesterol1.89886588
43MP0000703_abnormal_thymus_morphology1.78977337
44* MP0002429_abnormal_blood_cell1.78849312
45MP0003195_calcinosis1.77976394
46MP0009840_abnormal_foam_cell1.76838440
47* MP0001845_abnormal_inflammatory_respons1.74225207
48MP0004947_skin_inflammation1.69016913
49MP0002132_abnormal_respiratory_system1.68469227
50MP0001545_abnormal_hematopoietic_system1.61886699
51MP0005397_hematopoietic_system_phenotyp1.61886699
52MP0002277_abnormal_respiratory_mucosa1.57350725
53MP0001533_abnormal_skeleton_physiology1.56995295
54MP0002933_joint_inflammation1.51039698
55MP0009278_abnormal_bone_marrow1.49110505
56MP0005451_abnormal_body_composition1.47467824
57MP0000858_altered_metastatic_potential1.44020887
58MP0003448_altered_tumor_morphology1.38967798
59MP0008469_abnormal_protein_level1.29881385
60MP0000490_abnormal_crypts_of1.26673110
61MP0009764_decreased_sensitivity_to1.26468052
62MP0005167_abnormal_blood-brain_barrier1.25473181
63MP0003806_abnormal_nucleotide_metabolis1.19654340
64MP0005174_abnormal_tail_pigmentation1.17226569
65MP0005058_abnormal_lysosome_morphology1.13510131
66MP0000569_abnormal_digit_pigmentation1.11479897
67MP0008875_abnormal_xenobiotic_pharmacok1.10259558
68MP0005365_abnormal_bile_salt1.09039509
69MP0008057_abnormal_DNA_replication1.08603506
70MP0005085_abnormal_gallbladder_physiolo1.07475138
71MP0010307_abnormal_tumor_latency1.04328024
72MP0001851_eye_inflammation1.02638459
73MP0002019_abnormal_tumor_incidence1.01362885
74MP0000343_altered_response_to1.01311389
75MP0003252_abnormal_bile_duct0.96755680
76MP0005166_decreased_susceptibility_to0.95759170
77MP0005310_abnormal_salivary_gland0.93389143
78MP0002163_abnormal_gland_morphology0.92760145
79MP0003172_abnormal_lysosome_physiology0.92743280
80MP0001986_abnormal_taste_sensitivity0.90478767
81MP0004782_abnormal_surfactant_physiolog0.87493659
82MP0005075_abnormal_melanosome_morpholog0.85780867
83MP0004883_abnormal_blood_vessel0.85227397
84MP0001348_abnormal_lacrimal_gland0.81902084
85MP0002254_reproductive_system_inflammat0.81294961
86MP0003075_altered_response_to0.80179530
87MP0003690_abnormal_glial_cell0.79011687
88MP0009763_increased_sensitivity_to0.78221866
89MP0005164_abnormal_response_to0.78145806
90MP0002998_abnormal_bone_remodeling0.77648716
91MP0003646_muscle_fatigue0.76949029
92MP0003693_abnormal_embryo_hatching0.74437592
93MP0001663_abnormal_digestive_system0.73493295
94MP0009765_abnormal_xenobiotic_induced0.70954377
95MP0000920_abnormal_myelination0.70884870
96MP0005390_skeleton_phenotype0.70262273
97MP0002876_abnormal_thyroid_physiology0.70199970
98MP0001881_abnormal_mammary_gland0.67713698
99MP0005379_endocrine/exocrine_gland_phen0.67076077
100MP0002095_abnormal_skin_pigmentation0.65912019
101MP0005319_abnormal_enzyme/_coenzyme0.65650669
102MP0004742_abnormal_vestibular_system0.65281388
103MP0003045_fibrosis0.65018814
104MP0003828_pulmonary_edema0.64524407
105MP0005023_abnormal_wound_healing0.64350690
106MP0000249_abnormal_blood_vessel0.62150153
107MP0003795_abnormal_bone_structure0.61250413
108MP0008260_abnormal_autophagy0.60201592
109MP0000015_abnormal_ear_pigmentation0.58418322
110MP0003453_abnormal_keratinocyte_physiol0.56832752
111MP0000609_abnormal_liver_physiology0.56308843
112MP0003077_abnormal_cell_cycle0.55049456
113MP0004381_abnormal_hair_follicle0.54807768
114MP0001958_emphysema0.54407969
115MP0003656_abnormal_erythrocyte_physiolo0.50987304
116MP0000313_abnormal_cell_death0.50539789
117MP0010352_gastrointestinal_tract_polyps0.49548511
118MP0000598_abnormal_liver_morphology0.47796928
119MP0010094_abnormal_chromosome_stability0.47552291
120MP0004957_abnormal_blastocyst_morpholog0.46277956
121MP0005076_abnormal_cell_differentiation0.45261444
122MP0008873_increased_physiological_sensi0.44541993
123MP0000477_abnormal_intestine_morphology0.43889051
124MP0006054_spinal_hemorrhage0.43603325
125MP0002693_abnormal_pancreas_physiology0.42877019
126MP0003943_abnormal_hepatobiliary_system0.42402946
127MP0008961_abnormal_basal_metabolism0.41015247
128MP0000371_diluted_coat_color0.40954643
129MP0003183_abnormal_peptide_metabolism0.39481396
130MP0002136_abnormal_kidney_physiology0.39333518

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.68330184
2Elevated erythrocyte sedimentation rate (HP:0003565)5.68577530
3Myositis (HP:0100614)5.04117135
4Eczematoid dermatitis (HP:0000976)4.95758622
5T lymphocytopenia (HP:0005403)4.57137327
6Abnormality of T cells (HP:0002843)4.49109370
7Increased IgM level (HP:0003496)4.44912676
8Abnormality of T cell number (HP:0011839)4.44722111
9Thrombocytosis (HP:0001894)4.33745546
10Recurrent abscess formation (HP:0002722)4.25608095
11Recurrent fungal infections (HP:0002841)4.18416189
12Abnormality of T cell physiology (HP:0011840)4.13068948
13IgM deficiency (HP:0002850)4.03557350
14Retrobulbar optic neuritis (HP:0100654)4.02829850
15Optic neuritis (HP:0100653)4.02829850
16Autoimmune thrombocytopenia (HP:0001973)3.98863027
17Orchitis (HP:0100796)3.98373706
18Severe combined immunodeficiency (HP:0004430)3.81172284
19IgG deficiency (HP:0004315)3.79604238
20Mediastinal lymphadenopathy (HP:0100721)3.71373230
21Recurrent bronchitis (HP:0002837)3.66104762
22IgA deficiency (HP:0002720)3.64378011
23Recurrent viral infections (HP:0004429)3.59612182
24Abnormality of liposaccharide metabolism (HP:0010968)3.58866216
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.58866216
26Abnormality of glycolipid metabolism (HP:0010969)3.58866216
27Chronic otitis media (HP:0000389)3.58416308
28Nasal polyposis (HP:0100582)3.58282685
29Recurrent bacterial skin infections (HP:0005406)3.54828164
30Arterial thrombosis (HP:0004420)3.53182131
31Autoimmune hemolytic anemia (HP:0001890)3.51802222
32Panhypogammaglobulinemia (HP:0003139)3.44891367
33Gastrointestinal infarctions (HP:0005244)3.41574290
34Combined immunodeficiency (HP:0005387)3.35786068
35Increased density of long bones (HP:0006392)3.32294980
36Hypochromic anemia (HP:0001931)3.24118855
37Chronic diarrhea (HP:0002028)3.22076433
38Chronic obstructive pulmonary disease (HP:0006510)3.21938258
39Obstructive lung disease (HP:0006536)3.21938258
40Abnormality of the nasal mucosa (HP:0000433)3.21830416
41Chronic mucocutaneous candidiasis (HP:0002728)3.18417601
42Recurrent cutaneous fungal infections (HP:0011370)3.18417601
43Increased cerebral lipofuscin (HP:0011813)3.16625968
44Meningitis (HP:0001287)3.12922984
45Gingivitis (HP:0000230)3.10803358
46Vasculitis (HP:0002633)3.09820928
47Abnormal delayed hypersensitivity skin test (HP:0002963)3.05685493
48Abnormality of B cell number (HP:0010975)3.04989467
49B lymphocytopenia (HP:0010976)3.04989467
50Chest pain (HP:0100749)3.04185509
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.97601046
52Recurrent skin infections (HP:0001581)2.95031523
53Epistaxis (HP:0000421)2.93596873
54Gingival bleeding (HP:0000225)2.92562094
55Amaurosis fugax (HP:0100576)2.92413556
56Leukocytosis (HP:0001974)2.90149589
57Pulmonary infiltrates (HP:0002113)2.87592706
58Keratoconjunctivitis sicca (HP:0001097)2.85716364
59Hemoptysis (HP:0002105)2.82525846
60Joint swelling (HP:0001386)2.82384408
61Spontaneous hematomas (HP:0007420)2.81012173
62Hypergammaglobulinemia (HP:0010702)2.76850133
63Encephalitis (HP:0002383)2.74172051
64Thyroiditis (HP:0100646)2.72335680
65Abnormality of macrophages (HP:0004311)2.70741436
66Recurrent gram-negative bacterial infections (HP:0005420)2.67102896
67Hypochromic microcytic anemia (HP:0004840)2.66419683
68Abnormality of the prostate (HP:0008775)2.64042545
69Lymphopenia (HP:0001888)2.63290160
70Abnormality of cells of the lymphoid lineage (HP:0012140)2.61861262
71Petechiae (HP:0000967)2.61411364
72Loss of speech (HP:0002371)2.60937718
73Prolonged bleeding time (HP:0003010)2.58841600
74Keratoconjunctivitis (HP:0001096)2.56620002
75Abnormality of eosinophils (HP:0001879)2.46589365
76Pallor (HP:0000980)2.44671513
77Lymphoma (HP:0002665)2.41603416
78Abnormality of the pleura (HP:0002103)2.41072040
79Vacuolated lymphocytes (HP:0001922)2.40202558
80Pustule (HP:0200039)2.38932588
81Inflammation of the large intestine (HP:0002037)2.37916021
82Abnormal platelet function (HP:0011869)2.34048169
83Impaired platelet aggregation (HP:0003540)2.34048169
84Periodontitis (HP:0000704)2.33344036
85Progressive inability to walk (HP:0002505)2.33247702
86Pulmonary embolism (HP:0002204)2.31085193
87Facial diplegia (HP:0001349)2.30402910
88Episodic fever (HP:0001954)2.29365597
89Abnormality of cells of the erythroid lineage (HP:0012130)2.27850842
90Gastrointestinal inflammation (HP:0004386)2.27803624
91Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27485084
92Persistence of primary teeth (HP:0006335)2.26241301
93Hypoplasia of the thymus (HP:0000778)2.23647027
94Abnormal number of erythroid precursors (HP:0012131)2.23215734
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.21153408
96Increased serum ferritin (HP:0003281)2.20830554
97Fatigue (HP:0012378)2.18873217
98Acute myeloid leukemia (HP:0004808)2.17293620
99Anorexia (HP:0002039)2.15475471
100Cellulitis (HP:0100658)2.14961579
101Keratitis (HP:0000491)2.14344535
102Interstitial pulmonary disease (HP:0006530)2.14041306
103Reticulocytopenia (HP:0001896)2.11319798
104Gangrene (HP:0100758)2.10673235
105Abnormality of iron homeostasis (HP:0011031)2.10575131
106Eosinophilia (HP:0001880)2.09963170
107Systemic lupus erythematosus (HP:0002725)2.09566656
108Aplastic anemia (HP:0001915)2.08465359
109Hepatosplenomegaly (HP:0001433)2.04722519
110Increased CSF protein (HP:0002922)2.04593827
111Granulocytopenia (HP:0001913)2.04270828
112Polyneuropathy (HP:0001271)2.03186776
113Recurrent sinusitis (HP:0011108)2.03045595
114Bronchitis (HP:0012387)2.01306931
115Myelodysplasia (HP:0002863)2.00684016
116Urticaria (HP:0001025)2.00301736
117Abnormality of the endocardium (HP:0004306)2.00184053
118Increased IgE level (HP:0003212)2.00076072
119Thrombophlebitis (HP:0004418)1.99732486
120Poikiloderma (HP:0001029)1.99101907
121Abnormal platelet volume (HP:0011876)1.98317542
122Abnormality of transition element cation homeostasis (HP:0011030)1.98165541
123Entropion (HP:0000621)1.96361159
124Acute hepatic failure (HP:0006554)1.91353734
125Purpura (HP:0000979)1.86799479
126Myocardial infarction (HP:0001658)1.86292538
127Glomerulonephritis (HP:0000099)1.82125307
128Stomach cancer (HP:0012126)1.81824794
129Microcytic anemia (HP:0001935)1.81509847
130Arthralgia (HP:0002829)1.81070603
131Segmental peripheral demyelination/remyelination (HP:0003481)1.79463590
132Alveolar cell carcinoma (HP:0006519)1.77028727
133Recurrent pneumonia (HP:0006532)1.77003710
134Glomerulopathy (HP:0100820)1.76337916
135Osteomyelitis (HP:0002754)1.74126761

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.42116415
2TXK5.31548921
3ZAP703.43305536
4JAK33.21596195
5TEC2.78947393
6ITK2.66347730
7MAP3K142.46715125
8BTK2.44054089
9IKBKE2.29609038
10MAP2K32.15355709
11PRPF4B2.10556776
12TBK12.07120304
13KIT2.05939214
14EEF2K1.95620401
15TYK21.87769556
16PIM21.86938604
17ACVR1B1.84134019
18IKBKB1.80403110
19IRAK41.78479179
20BLK1.71185716
21MAP3K111.65664362
22TAOK11.65646035
23SYK1.63487536
24FRK1.61223821
25FGR1.58571657
26FGFR31.55979597
27LCK1.55269538
28TAOK21.51971481
29CSK1.50572229
30HCK1.48536517
31FGFR41.46331176
32STK101.44764832
33MARK31.43088230
34NME21.41317897
35FES1.39282300
36CHUK1.29570365
37MATK1.25230329
38KDR1.24565013
39JAK11.21568797
40GRK61.20303886
41MAP3K31.15243725
42MAP3K121.14317654
43PIM11.14307716
44IRAK31.14192285
45EPHB11.12876485
46LYN1.10437915
47CLK11.09806514
48GRK71.08115624
49CSF1R1.03357969
50TESK21.01325080
51BMPR21.01088647
52LRRK21.00919062
53TGFBR20.93874052
54RPS6KA40.92607583
55RPS6KB20.89365527
56TGFBR10.87490043
57FLT30.84664010
58DAPK20.81418508
59RAF10.76580268
60BCR0.76175407
61JAK20.72997142
62TAOK30.72090229
63NLK0.71178999
64PKN20.70315501
65MAP3K70.67562273
66ALK0.58549811
67TRPM70.58519852
68MAP3K130.55280878
69MAPK120.54818771
70TLK10.54560258
71MAP3K80.52882469
72ERN10.51939256
73PRKCQ0.51692448
74PASK0.51190099
75MST40.51099948
76TSSK60.51064583
77RIPK40.50729679
78STK110.50316662
79IRAK20.49790115
80PIK3CG0.49330263
81PRKG20.49126260
82KSR10.48392411
83CAMKK20.48387018
84MAP3K100.48020829
85KSR20.46479462
86TNK20.46435617
87EIF2AK10.46335191
88PRKCH0.45902493
89CDC42BPA0.45697436
90TRIB30.45546755
91CDK40.45526030
92PTK2B0.45521394
93PDK20.44779237
94MAP3K10.43936220
95RPS6KA50.43282766
96STK240.42800309
97ADRBK20.42713960
98PDPK10.41567312
99PAK40.41523239
100MAP3K50.41347591
101CAMKK10.40363724
102OXSR10.38786700
103PDK10.36585337
104ABL10.35974171
105FYN0.34949888
106MAPKAPK20.34789397
107IRAK10.34244677
108EGFR0.33956683
109SRPK10.33841356
110SIK20.33804500
111CDK60.33803169
112PRKCZ0.33179230
113WNK10.33008401
114HIPK20.32344176
115BRSK20.32202962
116RPS6KA10.31947048
117MAPK110.31457174
118TYRO30.30164664
119MAPKAPK30.29794650
120NME10.29667875
121GRK10.29471953
122EPHA30.29213631
123MAPK40.28820778
124PTK60.26813400
125IGF1R0.26325145
126BMPR1B0.26246428
127YES10.25802235
128CAMK40.25667482
129MAP3K20.25355121
130CDK190.25204984
131MAPK70.24821629
132RPS6KL10.24607228
133RPS6KC10.24607228
134PRKCD0.24448009
135RPS6KA60.24261228
136PRKAA20.23482723
137MAP2K60.22172614
138MAPK30.22129142
139SIK30.21896587

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053304.87827656
2Graft-versus-host disease_Homo sapiens_hsa053323.89539649
3Asthma_Homo sapiens_hsa053103.66458023
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.42530157
5Primary immunodeficiency_Homo sapiens_hsa053403.26541652
6Type I diabetes mellitus_Homo sapiens_hsa049402.91190377
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.69055461
8Autoimmune thyroid disease_Homo sapiens_hsa053202.67528070
9T cell receptor signaling pathway_Homo sapiens_hsa046602.59704383
10Leishmaniasis_Homo sapiens_hsa051402.50605776
11* NF-kappa B signaling pathway_Homo sapiens_hsa040642.41531697
12Measles_Homo sapiens_hsa051622.30278780
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.27308791
14Hematopoietic cell lineage_Homo sapiens_hsa046402.15402029
15Jak-STAT signaling pathway_Homo sapiens_hsa046302.02611941
16Antigen processing and presentation_Homo sapiens_hsa046121.93741250
17Osteoclast differentiation_Homo sapiens_hsa043801.77393939
18RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66865395
19Malaria_Homo sapiens_hsa051441.66650586
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.66265391
21Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.65643142
22* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.60367194
23Ribosome_Homo sapiens_hsa030101.52523662
24Legionellosis_Homo sapiens_hsa051341.52007705
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.49768973
26Toxoplasmosis_Homo sapiens_hsa051451.44253735
27* Herpes simplex infection_Homo sapiens_hsa051681.43159942
28Complement and coagulation cascades_Homo sapiens_hsa046101.41490859
29B cell receptor signaling pathway_Homo sapiens_hsa046621.41477110
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40752884
31Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.36543398
32TNF signaling pathway_Homo sapiens_hsa046681.33893782
33Lysosome_Homo sapiens_hsa041421.29938958
34Viral myocarditis_Homo sapiens_hsa054161.27425224
35DNA replication_Homo sapiens_hsa030301.24106370
36Phagosome_Homo sapiens_hsa041451.15902999
37Acute myeloid leukemia_Homo sapiens_hsa052211.13119025
38Hepatitis B_Homo sapiens_hsa051611.12750347
39Pertussis_Homo sapiens_hsa051331.07349424
40Influenza A_Homo sapiens_hsa051641.05477600
41Shigellosis_Homo sapiens_hsa051311.05416916
42Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.04538370
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03935533
44Chemokine signaling pathway_Homo sapiens_hsa040621.03119187
45Tuberculosis_Homo sapiens_hsa051521.02623505
46Apoptosis_Homo sapiens_hsa042101.00121741
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.99971142
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.97017149
49Staphylococcus aureus infection_Homo sapiens_hsa051500.95934647
50Salmonella infection_Homo sapiens_hsa051320.93811542
51Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.88802305
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.87069978
53Collecting duct acid secretion_Homo sapiens_hsa049660.86814389
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.86163620
55Rheumatoid arthritis_Homo sapiens_hsa053230.84169323
56HTLV-I infection_Homo sapiens_hsa051660.82276222
57Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.80492427
58Chronic myeloid leukemia_Homo sapiens_hsa052200.79949567
59Base excision repair_Homo sapiens_hsa034100.79759576
60African trypanosomiasis_Homo sapiens_hsa051430.79495063
61Caffeine metabolism_Homo sapiens_hsa002320.79372535
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.78049342
63Epstein-Barr virus infection_Homo sapiens_hsa051690.75941483
64Spliceosome_Homo sapiens_hsa030400.75603454
65Mismatch repair_Homo sapiens_hsa034300.74054347
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.73459321
67Prolactin signaling pathway_Homo sapiens_hsa049170.72441654
68Linoleic acid metabolism_Homo sapiens_hsa005910.67534746
69Pyrimidine metabolism_Homo sapiens_hsa002400.67169168
70Platelet activation_Homo sapiens_hsa046110.65374383
71Viral carcinogenesis_Homo sapiens_hsa052030.61840553
72AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.58071297
73Hepatitis C_Homo sapiens_hsa051600.58014551
74Pancreatic cancer_Homo sapiens_hsa052120.57049242
75Dorso-ventral axis formation_Homo sapiens_hsa043200.56291559
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.53155674
77Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.51198628
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49900801
79Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49417741
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.47855140
81PPAR signaling pathway_Homo sapiens_hsa033200.47364626
82alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.46878317
83p53 signaling pathway_Homo sapiens_hsa041150.46363208
84ABC transporters_Homo sapiens_hsa020100.43808384
85Small cell lung cancer_Homo sapiens_hsa052220.43746254
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43042522
87Amoebiasis_Homo sapiens_hsa051460.42680837
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.41554140
89Drug metabolism - other enzymes_Homo sapiens_hsa009830.40279366
90RNA polymerase_Homo sapiens_hsa030200.40254188
91Prion diseases_Homo sapiens_hsa050200.39656061
92VEGF signaling pathway_Homo sapiens_hsa043700.39612983
93FoxO signaling pathway_Homo sapiens_hsa040680.39021973
94Pentose phosphate pathway_Homo sapiens_hsa000300.38850174
95Systemic lupus erythematosus_Homo sapiens_hsa053220.38431457
96Proteasome_Homo sapiens_hsa030500.38142723
97RNA degradation_Homo sapiens_hsa030180.37770729
98Arachidonic acid metabolism_Homo sapiens_hsa005900.37749729
99Sulfur relay system_Homo sapiens_hsa041220.36696538
100Regulation of autophagy_Homo sapiens_hsa041400.35619476
101Nucleotide excision repair_Homo sapiens_hsa034200.35095916
102Non-homologous end-joining_Homo sapiens_hsa034500.34361011
103Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.32492744
104Chemical carcinogenesis_Homo sapiens_hsa052040.32400501
105Retinol metabolism_Homo sapiens_hsa008300.32010713
106Non-small cell lung cancer_Homo sapiens_hsa052230.31624068
107RNA transport_Homo sapiens_hsa030130.30492722
108Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29374185
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.28172503
110Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27130208
111One carbon pool by folate_Homo sapiens_hsa006700.26646421
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.25786196
113HIF-1 signaling pathway_Homo sapiens_hsa040660.25508929
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.25226200
115Type II diabetes mellitus_Homo sapiens_hsa049300.24893451
116Ether lipid metabolism_Homo sapiens_hsa005650.24871117
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23824328
118Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.23765836
119Glycerolipid metabolism_Homo sapiens_hsa005610.23398490
120Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23037107
121Other glycan degradation_Homo sapiens_hsa005110.22251769
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.22156923
123Colorectal cancer_Homo sapiens_hsa052100.22024274
124Homologous recombination_Homo sapiens_hsa034400.19750071
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.17970970
126Insulin resistance_Homo sapiens_hsa049310.17700420
127Thyroid cancer_Homo sapiens_hsa052160.16841873
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.16082649
129Tryptophan metabolism_Homo sapiens_hsa003800.15859083
130MAPK signaling pathway_Homo sapiens_hsa040100.14405754
131Cell cycle_Homo sapiens_hsa041100.14193172
132Notch signaling pathway_Homo sapiens_hsa043300.13294608
133MicroRNAs in cancer_Homo sapiens_hsa052060.12060563

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