TNFRSF25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)8.47697957
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)8.47697957
3response to interleukin-15 (GO:0070672)7.95116824
4negative T cell selection (GO:0043383)7.74298530
5cellular response to interleukin-15 (GO:0071350)7.67546834
6negative thymic T cell selection (GO:0045060)7.59478125
7positive regulation of gamma-delta T cell activation (GO:0046645)7.24985357
8positive thymic T cell selection (GO:0045059)6.99190805
9regulation of gamma-delta T cell differentiation (GO:0045586)6.96272028
10regulation of isotype switching to IgG isotypes (GO:0048302)6.83850293
11tolerance induction (GO:0002507)6.74506032
12positive T cell selection (GO:0043368)6.66233832
13thymic T cell selection (GO:0045061)6.59127930
14positive regulation of interleukin-2 biosynthetic process (GO:0045086)6.42242015
15regulation of gamma-delta T cell activation (GO:0046643)6.22585193
16T cell selection (GO:0045058)6.20511573
17interferon-gamma production (GO:0032609)6.08027777
18regulation of T cell tolerance induction (GO:0002664)5.79493651
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.49072705
20T cell receptor signaling pathway (GO:0050852)5.36706122
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.34852079
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.34852079
23T cell migration (GO:0072678)5.34187910
24regulation of interleukin-2 biosynthetic process (GO:0045076)5.19874765
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.08472995
26T cell costimulation (GO:0031295)4.98165877
27positive regulation of tolerance induction (GO:0002645)4.93737003
28lymphocyte costimulation (GO:0031294)4.91641393
29leukocyte aggregation (GO:0070486)4.75296875
30regulation of regulatory T cell differentiation (GO:0045589)4.61431881
31regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.45294906
32negative regulation of T cell mediated immunity (GO:0002710)4.42929483
33antigen receptor-mediated signaling pathway (GO:0050851)4.40560186
34antigen processing and presentation of endogenous antigen (GO:0019883)4.28822291
35regulation of B cell receptor signaling pathway (GO:0050855)4.27042785
36regulation of tolerance induction (GO:0002643)4.22986964
37positive regulation of T cell differentiation in thymus (GO:0033089)4.14699417
38negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.12027262
39positive regulation of interleukin-2 production (GO:0032743)4.11842871
40regulation of interleukin-12 biosynthetic process (GO:0045075)4.09997421
41alpha-beta T cell differentiation (GO:0046632)3.93326953
42positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.86227256
43positive regulation of natural killer cell mediated immunity (GO:0002717)3.86227256
44regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.83441743
45regulation of natural killer cell mediated immunity (GO:0002715)3.83441743
46regulation of isotype switching (GO:0045191)3.82557152
47T-helper cell differentiation (GO:0042093)3.81674077
48CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.81674077
49alpha-beta T cell activation (GO:0046631)3.80291541
50regulation of leukocyte mediated cytotoxicity (GO:0001910)3.77494153
51regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.75790591
52regulation of T cell receptor signaling pathway (GO:0050856)3.75021112
53T cell differentiation (GO:0030217)3.74581203
54regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.70200702
55regulation of alpha-beta T cell proliferation (GO:0046640)3.68267333
56negative regulation of lymphocyte mediated immunity (GO:0002707)3.67533669
57regulation of response to interferon-gamma (GO:0060330)3.67154667
58activated T cell proliferation (GO:0050798)3.66021035
59positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.65154681
60regulation of T cell mediated cytotoxicity (GO:0001914)3.64331928
61mast cell activation (GO:0045576)3.63121912
62positive regulation of isotype switching (GO:0045830)3.62077881
63JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.57997554
64regulation of chronic inflammatory response (GO:0002676)3.49203533
65regulation of interleukin-2 production (GO:0032663)3.47057181
66regulation of cell killing (GO:0031341)3.44736459
67regulation of immunoglobulin mediated immune response (GO:0002889)3.44249525
68negative regulation of leukocyte mediated immunity (GO:0002704)3.41578507
69mast cell activation involved in immune response (GO:0002279)3.41492767
70mast cell degranulation (GO:0043303)3.41492767
71T cell differentiation involved in immune response (GO:0002292)3.39707476
72alpha-beta T cell differentiation involved in immune response (GO:0002293)3.39707476
73alpha-beta T cell activation involved in immune response (GO:0002287)3.39707476
74tyrosine phosphorylation of STAT protein (GO:0007260)3.39139444
75positive regulation of humoral immune response (GO:0002922)3.39043252
76NIK/NF-kappaB signaling (GO:0038061)3.35875744
77positive regulation of alpha-beta T cell proliferation (GO:0046641)3.33863169
78regulation of B cell mediated immunity (GO:0002712)3.30852393
79positive regulation of granulocyte differentiation (GO:0030854)3.30499909
80CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.30161244
81response to muramyl dipeptide (GO:0032495)3.29507873
82T cell activation (GO:0042110)3.26652232
83negative regulation of innate immune response (GO:0045824)3.25883150
84positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25357579
85regulation of defense response to virus by virus (GO:0050690)3.24916566
86positive regulation of cell killing (GO:0031343)3.23257238
87positive regulation of B cell mediated immunity (GO:0002714)3.22949170
88positive regulation of immunoglobulin mediated immune response (GO:0002891)3.22949170
89lymph node development (GO:0048535)3.22174263
90regulation of memory T cell differentiation (GO:0043380)3.22017575
91T cell homeostasis (GO:0043029)3.21823431
92regulation of type I interferon-mediated signaling pathway (GO:0060338)3.16819071
93natural killer cell activation (GO:0030101)3.16524684
94regulation of immunoglobulin production (GO:0002637)3.15358984
95mucosal-associated lymphoid tissue development (GO:0048537)3.13932287
96Peyers patch development (GO:0048541)3.13932287
97positive regulation of DNA recombination (GO:0045911)3.12549805
98lymphocyte migration (GO:0072676)3.12283143
99CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.12186904
100positive regulation of T cell differentiation (GO:0045582)3.11927410
101negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.11294436
102negative regulation of T cell receptor signaling pathway (GO:0050860)3.10969229
103mature B cell differentiation (GO:0002335)3.10027776
104negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.08990991
105regulation of T cell mediated immunity (GO:0002709)3.08894116
106positive regulation of T cell mediated cytotoxicity (GO:0001916)3.08240073
107immune response-activating cell surface receptor signaling pathway (GO:0002429)3.08234028
108RNA destabilization (GO:0050779)3.06331080
109positive regulation of T cell activation (GO:0050870)3.06083527
110positive regulation of defense response to virus by host (GO:0002230)3.01453657
111negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.98955945
112positive regulation of T cell mediated immunity (GO:0002711)2.93906885
113regulation of alpha-beta T cell activation (GO:0046634)2.85562534
114positive regulation of interleukin-4 production (GO:0032753)2.84737697
115negative regulation of adaptive immune response (GO:0002820)2.83347404
116antigen processing and presentation via MHC class Ib (GO:0002475)2.80780859
117negative regulation of T-helper cell differentiation (GO:0045623)2.80296746
118negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.80296746
119lymphocyte homeostasis (GO:0002260)2.75683067
120regulation of defense response to virus by host (GO:0050691)2.71058161
121dendritic cell chemotaxis (GO:0002407)2.70019438
122regulation of interleukin-4 production (GO:0032673)2.69711161
123regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.68641426
124positive regulation of alpha-beta T cell activation (GO:0046635)2.68589617
125regulation of T cell cytokine production (GO:0002724)2.68433832
126regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.66328313
127negative regulation of interleukin-10 production (GO:0032693)2.64491242
128regulation of alpha-beta T cell differentiation (GO:0046637)2.62740503
129negative regulation of interleukin-1 beta production (GO:0032691)2.62713200
130CD4-positive, alpha-beta T cell activation (GO:0035710)2.62655712
131positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.61098215
132positive regulation of alpha-beta T cell differentiation (GO:0046638)2.58884882

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse8.87096108
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human7.64812683
3RUNX_20019798_ChIP-Seq_JUKART_Human4.42530835
4STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.22744541
5FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.96728218
6MYC_22102868_ChIP-Seq_BL_Human3.89970679
7* STAT4_19710469_ChIP-ChIP_TH1__Mouse3.66913262
8MYB_26560356_Chip-Seq_TH2_Human3.36509499
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.34199592
10MAF_26560356_Chip-Seq_TH1_Human3.21107725
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.03008890
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.00738666
13IRF8_22096565_ChIP-ChIP_GC-B_Human2.98272880
14MYB_26560356_Chip-Seq_TH1_Human2.94942977
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.86892317
16UTX_26944678_Chip-Seq_JUKART_Human2.86433060
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.78131446
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.46003379
19TCF7_22412390_ChIP-Seq_EML_Mouse2.41000528
20* MAF_26560356_Chip-Seq_TH2_Human2.29346287
21BP1_19119308_ChIP-ChIP_Hs578T_Human2.29192608
22KDM2B_26808549_Chip-Seq_DND41_Human2.29097343
23VDR_21846776_ChIP-Seq_THP-1_Human2.28024909
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27144583
25KDM2B_26808549_Chip-Seq_SUP-B15_Human2.23480483
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.23218755
27KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.21943715
28EZH2_22144423_ChIP-Seq_EOC_Human2.07998880
29GATA3_27048872_Chip-Seq_THYMUS_Human2.04477889
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.01222310
31RUNX1_22412390_ChIP-Seq_EML_Mouse2.01032147
32E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.99576561
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.98925504
34SCL_19346495_ChIP-Seq_HPC-7_Human1.96608751
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79631919
36SMAD_19615063_ChIP-ChIP_OVARY_Human1.78658485
37RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.78533397
38KDM2B_26808549_Chip-Seq_JURKAT_Human1.78155543
39SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71769624
40VDR_24763502_ChIP-Seq_THP-1_Human1.61714980
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.60740234
42SPI1_23127762_ChIP-Seq_K562_Human1.54334983
43NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.51829678
44SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.47348331
45MYB_21317192_ChIP-Seq_ERMYB_Mouse1.45975917
46IKZF1_21737484_ChIP-ChIP_HCT116_Human1.45833777
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45647350
48* ELK3_25401928_ChIP-Seq_HUVEC_Human1.45296600
49IRF8_27001747_Chip-Seq_BMDM_Mouse1.45001657
50BCL6_27268052_Chip-Seq_Bcells_Human1.42848278
51RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42351916
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.42176790
53P68_20966046_ChIP-Seq_HELA_Human1.37729935
54SPI1_23547873_ChIP-Seq_NB4_Human1.35611128
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.30525436
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.29751305
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28055470
58BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27753810
59BCOR_27268052_Chip-Seq_Bcells_Human1.22385609
60TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21521134
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.20684325
62CIITA_25753668_ChIP-Seq_RAJI_Human1.16019658
63EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14069875
64PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.10502152
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.09361347
66PU_27001747_Chip-Seq_BMDM_Mouse1.08163045
67* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08054942
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06795466
69* CTCF_27219007_Chip-Seq_Bcells_Human1.05420892
70* GATA3_26560356_Chip-Seq_TH2_Human1.04067575
71RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03886767
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03782252
73LXR_22292898_ChIP-Seq_THP-1_Human1.03399417
74E2F1_20622854_ChIP-Seq_HELA_Human1.02851916
75REST_21632747_ChIP-Seq_MESCs_Mouse1.01678975
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.00652045
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99345467
78SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.98089440
79* SA1_27219007_Chip-Seq_Bcells_Human0.97991088
80SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.97048394
81* P300_27268052_Chip-Seq_Bcells_Human0.96588302
82* PHF8_20622854_ChIP-Seq_HELA_Human0.96132141
83RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.95815157
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94208605
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.92094794
86JARID2_20064375_ChIP-Seq_MESCs_Mouse0.91929217
87* OCT4_19829295_ChIP-Seq_ESCs_Human0.91460510
88NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.91223429
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.90507499
90GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90422391
91* VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.89161966
92GATA2_22383799_ChIP-Seq_G1ME_Mouse0.88388504
93NCOR1_26117541_ChIP-Seq_K562_Human0.87174077
94MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86193544
95SMC4_20622854_ChIP-Seq_HELA_Human0.85781469
96PU.1_20513432_ChIP-Seq_Bcells_Mouse0.85454600
97DROSHA_22980978_ChIP-Seq_HELA_Human0.85345666
98ERA_21632823_ChIP-Seq_H3396_Human0.85231342
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85182405
100CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.85000422
101CTCF_20526341_ChIP-Seq_ESCs_Human0.84730175
102RARB_27405468_Chip-Seq_BRAIN_Mouse0.84691192
103LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.83155657
104GATA1_19941826_ChIP-Seq_K562_Human0.82923299
105CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82830231
106RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82741528
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82418404
108REST_18959480_ChIP-ChIP_MESCs_Mouse0.81628498
109GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.81139267
110LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.80354291
111* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80173417
112* RNF2_27304074_Chip-Seq_ESCs_Mouse0.79849817
113* KDM2B_26808549_Chip-Seq_K562_Human0.78817823
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.78784812
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.78450000
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78343166
117* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.77279612
118GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76456462
119E2F7_22180533_ChIP-Seq_HELA_Human0.74426090
120PRDM14_20953172_ChIP-Seq_ESCs_Human0.73918748
121VDR_24787735_ChIP-Seq_THP-1_Human0.73736774
122CTCF_21964334_ChIP-Seq_BJAB-B_Human0.73706115
123ZFP281_27345836_Chip-Seq_ESCs_Mouse0.73682874
124FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73005977
125SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72557583
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.71880372
127CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70700765
128DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.69531829
129GATA2_19941826_ChIP-Seq_K562_Human0.69478830
130* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.69035788
131PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67049946
132ELF1_20517297_ChIP-Seq_JURKAT_Human0.66577245
133CLOCK_20551151_ChIP-Seq_293T_Human0.65873011
134* SA1_27219007_Chip-Seq_ERYTHROID_Human0.65761454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology6.21521043
2MP0005671_abnormal_response_to4.58919034
3MP0000685_abnormal_immune_system3.93516238
4MP0001800_abnormal_humoral_immune3.24358311
5MP0005387_immune_system_phenotype3.06200639
6MP0001790_abnormal_immune_system3.06200639
7MP0005000_abnormal_immune_tolerance2.96939238
8MP0002723_abnormal_immune_serum2.89455442
9* MP0002420_abnormal_adaptive_immunity2.79669115
10* MP0002398_abnormal_bone_marrow2.77061038
11* MP0001819_abnormal_immune_cell2.75236971
12MP0001873_stomach_inflammation2.74635341
13MP0002405_respiratory_system_inflammati2.70858431
14* MP0000703_abnormal_thymus_morphology2.69904567
15MP0003866_abnormal_defecation2.69509485
16MP0003724_increased_susceptibility_to2.66740589
17MP0004510_myositis2.58898585
18MP0010155_abnormal_intestine_physiology2.55761767
19MP0009333_abnormal_splenocyte_physiolog2.52880505
20MP0009785_altered_susceptibility_to2.47273422
21MP0002452_abnormal_antigen_presenting2.47084472
22MP0002166_altered_tumor_susceptibility2.44772910
23MP0001835_abnormal_antigen_presentation2.41845436
24* MP0000716_abnormal_immune_system2.38762149
25MP0003436_decreased_susceptibility_to2.36744041
26MP0002933_joint_inflammation2.32823212
27MP0002396_abnormal_hematopoietic_system2.26348952
28* MP0002722_abnormal_immune_system2.26255252
29MP0000689_abnormal_spleen_morphology2.12505118
30MP0005025_abnormal_response_to2.05898450
31MP0003300_gastrointestinal_ulcer2.01058035
32MP0004947_skin_inflammation1.98071829
33* MP0002429_abnormal_blood_cell1.92881189
34MP0002006_tumorigenesis1.88102523
35MP0002822_catalepsy1.87989367
36MP0006082_CNS_inflammation1.76539279
37MP0004859_abnormal_synaptic_plasticity1.73845956
38MP0003303_peritoneal_inflammation1.69214289
39MP0001348_abnormal_lacrimal_gland1.68893026
40MP0001986_abnormal_taste_sensitivity1.67632467
41MP0002148_abnormal_hypersensitivity_rea1.60205773
42MP0002419_abnormal_innate_immunity1.58491591
43MP0004885_abnormal_endolymph1.57870220
44MP0001845_abnormal_inflammatory_respons1.57670678
45MP0004130_abnormal_muscle_cell1.56434043
46MP0004808_abnormal_hematopoietic_stem1.56372361
47MP0008961_abnormal_basal_metabolism1.55868215
48MP0004742_abnormal_vestibular_system1.38158636
49MP0004381_abnormal_hair_follicle1.37241269
50MP0001853_heart_inflammation1.36750620
51MP0005464_abnormal_platelet_physiology1.31285909
52MP0001851_eye_inflammation1.27957676
53MP0000465_gastrointestinal_hemorrhage1.27775144
54MP0003879_abnormal_hair_cell1.26542649
55MP0001968_abnormal_touch/_nociception1.23189051
56MP0000858_altered_metastatic_potential1.13859393
57MP0001533_abnormal_skeleton_physiology1.11252463
58MP0005310_abnormal_salivary_gland1.11217116
59MP0001501_abnormal_sleep_pattern1.07880806
60MP0008872_abnormal_physiological_respon1.07114537
61MP0002272_abnormal_nervous_system1.02050083
62MP0005075_abnormal_melanosome_morpholog1.01573931
63MP0002138_abnormal_hepatobiliary_system1.01236894
64MP0003880_abnormal_central_pattern1.01107879
65MP0002064_seizures1.00881085
66MP0000490_abnormal_crypts_of0.99604015
67MP0008569_lethality_at_weaning0.94403422
68MP0004142_abnormal_muscle_tone0.93171517
69MP0008469_abnormal_protein_level0.93076149
70MP0002063_abnormal_learning/memory/cond0.91836356
71MP0002998_abnormal_bone_remodeling0.90699117
72MP0002653_abnormal_ependyma_morphology0.85314715
73MP0005397_hematopoietic_system_phenotyp0.84922843
74MP0001545_abnormal_hematopoietic_system0.84922843
75MP0001486_abnormal_startle_reflex0.84436357
76MP0003638_abnormal_response/metabolism_0.81504605
77MP0003172_abnormal_lysosome_physiology0.81387973
78MP0002876_abnormal_thyroid_physiology0.80968768
79MP0001919_abnormal_reproductive_system0.80513515
80MP0000604_amyloidosis0.80422206
81MP0002163_abnormal_gland_morphology0.79070430
82MP0002928_abnormal_bile_duct0.78528428
83MP0003045_fibrosis0.76959935
84MP0002254_reproductive_system_inflammat0.75735296
85MP0002572_abnormal_emotion/affect_behav0.75420538
86MP0003646_muscle_fatigue0.74897954
87MP0001485_abnormal_pinna_reflex0.73455623
88MP0005390_skeleton_phenotype0.73432318
89MP0003787_abnormal_imprinting0.70347163
90MP0002277_abnormal_respiratory_mucosa0.69011152
91MP0003448_altered_tumor_morphology0.67650357
92MP0001970_abnormal_pain_threshold0.67558930
93MP0001440_abnormal_grooming_behavior0.66526529
94MP0002019_abnormal_tumor_incidence0.64148483
95MP0009765_abnormal_xenobiotic_induced0.64098248
96MP0003828_pulmonary_edema0.63861597
97MP0002067_abnormal_sensory_capabilities0.63579017
98MP0008877_abnormal_DNA_methylation0.62512925
99MP0009764_decreased_sensitivity_to0.62051717
100MP0005535_abnormal_body_temperature0.61258766
101MP0000609_abnormal_liver_physiology0.60034518
102MP0005076_abnormal_cell_differentiation0.59492250
103MP0002693_abnormal_pancreas_physiology0.59107580
104MP0002733_abnormal_thermal_nociception0.59038350
105MP0003091_abnormal_cell_migration0.58966971
106MP0005381_digestive/alimentary_phenotyp0.58633642
107MP0010234_abnormal_vibrissa_follicle0.58434848
108MP0003279_aneurysm0.58053122
109MP0009278_abnormal_bone_marrow0.57980712
110MP0002132_abnormal_respiratory_system0.57096697
111MP0001663_abnormal_digestive_system0.56751651
112MP0005670_abnormal_white_adipose0.56456176
113MP0009763_increased_sensitivity_to0.55751510
114MP0003635_abnormal_synaptic_transmissio0.55043822
115MP0000477_abnormal_intestine_morphology0.54927587
116MP0003878_abnormal_ear_physiology0.53612366
117MP0005377_hearing/vestibular/ear_phenot0.53612366
118MP0005165_increased_susceptibility_to0.53573622
119MP0001765_abnormal_ion_homeostasis0.51655353
120MP0003329_amyloid_beta_deposits0.51372208
121MP0002009_preneoplasia0.51357389
122MP0005023_abnormal_wound_healing0.51340302
123MP0008770_decreased_survivor_rate0.50573901
124MP0010352_gastrointestinal_tract_polyps0.50399716
125MP0005423_abnormal_somatic_nervous0.50240890
126MP0001881_abnormal_mammary_gland0.48845443
127MP0003075_altered_response_to0.48694499
128MP0001502_abnormal_circadian_rhythm0.47644379
129MP0000249_abnormal_blood_vessel0.47094549
130MP0004185_abnormal_adipocyte_glucose0.45064901
131MP0002083_premature_death0.44299719
132MP0005174_abnormal_tail_pigmentation0.43799723
133MP0009745_abnormal_behavioral_response0.41987527
134MP0008007_abnormal_cellular_replicative0.41357401
135MP0000343_altered_response_to0.40332399

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)7.49537963
2Abnormality of T cell number (HP:0011839)7.08086811
3Severe combined immunodeficiency (HP:0004430)5.79179927
4Abnormality of T cells (HP:0002843)5.63153861
5Stomatitis (HP:0010280)5.33477818
6Combined immunodeficiency (HP:0005387)5.22753852
7IgM deficiency (HP:0002850)5.06965980
8Recurrent bronchitis (HP:0002837)4.98563151
9Elevated erythrocyte sedimentation rate (HP:0003565)4.92725155
10Myositis (HP:0100614)4.72713720
11Chronic mucocutaneous candidiasis (HP:0002728)4.65984637
12Recurrent cutaneous fungal infections (HP:0011370)4.65984637
13Panhypogammaglobulinemia (HP:0003139)4.56676039
14Recurrent fungal infections (HP:0002841)4.50705618
15Chronic diarrhea (HP:0002028)4.32983724
16IgG deficiency (HP:0004315)4.24058590
17Abnormal delayed hypersensitivity skin test (HP:0002963)4.15891430
18Nasal polyposis (HP:0100582)4.15567613
19Papilledema (HP:0001085)3.99997084
20Retrobulbar optic neuritis (HP:0100654)3.95224211
21Optic neuritis (HP:0100653)3.95224211
22Abnormality of T cell physiology (HP:0011840)3.89580726
23Chronic otitis media (HP:0000389)3.80794125
24Abnormality of eosinophils (HP:0001879)3.71206783
25Autoimmune hemolytic anemia (HP:0001890)3.65593220
26Orchitis (HP:0100796)3.64874359
27Increased density of long bones (HP:0006392)3.59964818
28Abnormality of the nasal mucosa (HP:0000433)3.56890717
29Recurrent viral infections (HP:0004429)3.50289154
30Joint swelling (HP:0001386)3.48648713
31Stomach cancer (HP:0012126)3.47865586
32Keratoconjunctivitis sicca (HP:0001097)3.42894156
33Pulmonary infiltrates (HP:0002113)3.40062108
34Thyroiditis (HP:0100646)3.38456024
35IgA deficiency (HP:0002720)3.36389607
36Pustule (HP:0200039)3.34031177
37Hemoptysis (HP:0002105)3.28970287
38B lymphocytopenia (HP:0010976)3.22321389
39Abnormality of B cell number (HP:0010975)3.22321389
40Lymphopenia (HP:0001888)3.19253297
41Eczematoid dermatitis (HP:0000976)3.15058961
42Abnormality of the fingertips (HP:0001211)3.09013815
43Keratoconjunctivitis (HP:0001096)3.05521599
44Leukocytosis (HP:0001974)3.03006348
45Abnormality of cells of the lymphoid lineage (HP:0012140)3.02956774
46Persistence of primary teeth (HP:0006335)2.95929508
47Increased IgM level (HP:0003496)2.94841259
48Basal cell carcinoma (HP:0002671)2.82608847
49Increased IgE level (HP:0003212)2.71268056
50Hemiplegia (HP:0002301)2.70845414
51Recurrent sinusitis (HP:0011108)2.68375692
52Inflammation of the large intestine (HP:0002037)2.65224978
53Bronchitis (HP:0012387)2.63600737
54Arterial thrombosis (HP:0004420)2.63549005
55Gastrointestinal infarctions (HP:0005244)2.58744459
56Encephalitis (HP:0002383)2.57917597
57Gastrointestinal inflammation (HP:0004386)2.55707211
58Vasculitis (HP:0002633)2.54331231
59Genetic anticipation (HP:0003743)2.52909317
60Spontaneous hematomas (HP:0007420)2.52143339
61Eosinophilia (HP:0001880)2.49166443
62Obstructive sleep apnea (HP:0002870)2.48489208
63Cheilitis (HP:0100825)2.46605752
64Meningitis (HP:0001287)2.37155864
65Hypoplasia of the thymus (HP:0000778)2.33299918
66Hypochromic anemia (HP:0001931)2.32530650
67Abnormality of binocular vision (HP:0011514)2.31622449
68Diplopia (HP:0000651)2.31622449
69Progressive cerebellar ataxia (HP:0002073)2.29928571
70Congenital stationary night blindness (HP:0007642)2.29621289
71Recurrent bacterial skin infections (HP:0005406)2.26847718
72Granulocytopenia (HP:0001913)2.25131555
73Mediastinal lymphadenopathy (HP:0100721)2.25033309
74Ureteral stenosis (HP:0000071)2.20085575
75Lymphoma (HP:0002665)2.19814564
76Chest pain (HP:0100749)2.18340947
77Pulmonary embolism (HP:0002204)2.17231111
78Premature loss of primary teeth (HP:0006323)2.17149423
79Clumsiness (HP:0002312)2.14851092
80Type II lissencephaly (HP:0007260)2.14743933
81Prolonged bleeding time (HP:0003010)2.12887182
82Hypergammaglobulinemia (HP:0010702)2.11562644
83Agammaglobulinemia (HP:0004432)2.09833691
84Visual hallucinations (HP:0002367)2.09480683
85Asplenia (HP:0001746)2.08709956
86Alveolar cell carcinoma (HP:0006519)2.07537593
87Aplasia/Hypoplasia of the spleen (HP:0010451)2.06644241
88Recurrent skin infections (HP:0001581)2.05226100
89Abnormal platelet volume (HP:0011876)2.04704193
90Chronic sinusitis (HP:0011109)1.99934717
91Supernumerary bones of the axial skeleton (HP:0009144)1.98647920
92Thrombocytosis (HP:0001894)1.97868321
93Recurrent otitis media (HP:0000403)1.96197180
94Abnormality of the endocardium (HP:0004306)1.95855124
95Abnormality of the lower motor neuron (HP:0002366)1.95417537
96Bicuspid aortic valve (HP:0001647)1.94877663
97Recurrent abscess formation (HP:0002722)1.94181626
98Ureteral obstruction (HP:0006000)1.93581710
99Emphysema (HP:0002097)1.93427285
100Epistaxis (HP:0000421)1.93238361
101Conical tooth (HP:0000698)1.89679536
102Neoplasm of the tracheobronchial system (HP:0100552)1.84716143
103Hepatitis (HP:0012115)1.84559342
104Autoimmune thrombocytopenia (HP:0001973)1.83158750
105Acrocyanosis (HP:0001063)1.82926378
106Annular pancreas (HP:0001734)1.82188468
107Colitis (HP:0002583)1.80970176
108Metabolic alkalosis (HP:0200114)1.80023861
109Absent rod-and cone-mediated responses on ERG (HP:0007688)1.79472408
110Papilloma (HP:0012740)1.78830749
111Verrucae (HP:0200043)1.78830749
112Hematochezia (HP:0002573)1.76838621
113Abnormality of the pleura (HP:0002103)1.76553248
114Decreased circulating renin level (HP:0003351)1.76243229
115Broad palm (HP:0001169)1.75969155
116Keratitis (HP:0000491)1.74544377
117Dyskinesia (HP:0100660)1.73838986
118Bronchiectasis (HP:0002110)1.73560338
119Hyperlipoproteinemia (HP:0010980)1.72233589
120Hypochromic microcytic anemia (HP:0004840)1.70278499
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.69632183
122Arthralgia (HP:0002829)1.68962273
123Abnormal rod and cone electroretinograms (HP:0008323)1.68699196
124Chronic obstructive pulmonary disease (HP:0006510)1.68614979
125Obstructive lung disease (HP:0006536)1.68614979
126Anorexia (HP:0002039)1.67970039
127Abnormality of the columella (HP:0009929)1.67773416
128Spinal canal stenosis (HP:0003416)1.67342408
129Gastrointestinal stroma tumor (HP:0100723)1.67148659

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK6.33508835
2MAP4K15.57092304
3ITK3.21108056
4JAK33.14599284
5ZAP703.10011112
6JAK12.61866602
7FGFR42.60910850
8MAP3K142.42921850
9NLK2.37886660
10CAMKK12.35220171
11IKBKE2.31554827
12TYK22.20438523
13GRK62.15980553
14MAP3K132.07428973
15STK102.00542708
16CAMKK21.94828028
17LCK1.88976945
18PASK1.88443872
19TEC1.86467377
20EEF2K1.83023154
21MAP2K21.78258886
22RIPK41.62792576
23KDR1.59150669
24SIK21.56973249
25TBK11.53974567
26HCK1.49433050
27TNIK1.48900808
28FGFR31.44926675
29CLK11.41866018
30MAP3K71.37516700
31IRAK31.31345530
32SYK1.30905353
33PRKCH1.22617245
34PRKCQ1.21547452
35IKBKB1.17765864
36FES1.16027503
37MARK21.15127485
38CSK1.13461663
39BTK1.09623814
40EPHA31.05082606
41PKN21.04826529
42TAOK31.03556069
43EPHB11.01240326
44MAP3K121.01118672
45TLK10.99174843
46TGFBR20.98986730
47MAPK150.98084229
48MARK30.97982303
49JAK20.97854917
50CHUK0.97050664
51TAOK10.96571400
52BRD40.96014517
53SIK30.87865557
54MAP3K100.87661541
55CDK120.87637876
56TRIB30.86935310
57TNK20.86611394
58IRAK40.85907994
59TYRO30.85056541
60TSSK60.82209767
61PIM10.79841985
62ADRBK20.76288669
63PDGFRB0.75529552
64CDC42BPA0.73998753
65BLK0.73436774
66MAP3K110.69519814
67MAP2K30.69307630
68PRKD20.66833004
69KIT0.66259416
70MAPK130.65145286
71DAPK20.64044606
72TTN0.63530224
73FGFR20.63185056
74FGFR10.62646898
75LYN0.61683267
76PINK10.60881520
77UHMK10.60673872
78PRPF4B0.59795992
79RPS6KA60.59581417
80ALK0.59117832
81INSR0.55927429
82IGF1R0.55043016
83STK380.54941352
84MUSK0.54712768
85SIK10.54583955
86INSRR0.53881011
87CAMK40.52579182
88FYN0.52405324
89ERN10.52189835
90DYRK1B0.51611691
91NEK60.50095138
92DMPK0.49955720
93TESK20.49228394
94PDK10.48685539
95TAOK20.47164435
96RPS6KL10.47110566
97RPS6KC10.47110566
98RPS6KA40.47058959
99MAP4K20.46623271
100NTRK20.46365199
101GRK10.45239756
102CSF1R0.44116969
103GRK50.43990508
104RPS6KA20.43550124
105CDK40.41871531
106NTRK30.41566654
107LRRK20.41245372
108MAPK120.41160301
109SGK4940.40062691
110SGK2230.40062691
111RAF10.39451168
112MST40.38577080
113MAPK40.36855568
114EPHA40.35186282
115PTK2B0.34734100
116PTK60.34167962
117IRAK10.32349084
118PAK60.31948748
119RET0.31799117
120HIPK20.31514865
121DAPK10.29239704
122MAPK70.27432987
123CAMK10.22708352
124TIE10.19665806
125STK110.18852512
126SRC0.18787649
127MAPK30.18770365
128PTK20.18561534
129MAPK80.18301948
130MAPK110.18170308
131MAP3K10.17853406
132CDK90.16815340
133MAP2K60.16127439
134ROCK20.15395725

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.20560807
2T cell receptor signaling pathway_Homo sapiens_hsa046603.95391762
3Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.82618702
4Measles_Homo sapiens_hsa051622.70149514
5Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.68504007
6NF-kappa B signaling pathway_Homo sapiens_hsa040642.54861562
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.52544377
8Osteoclast differentiation_Homo sapiens_hsa043802.07695202
9Hematopoietic cell lineage_Homo sapiens_hsa046402.00266667
10Jak-STAT signaling pathway_Homo sapiens_hsa046301.92223327
11Allograft rejection_Homo sapiens_hsa053301.80993275
12B cell receptor signaling pathway_Homo sapiens_hsa046621.70048984
13Viral myocarditis_Homo sapiens_hsa054161.58835939
14Leishmaniasis_Homo sapiens_hsa051401.56673007
15Antigen processing and presentation_Homo sapiens_hsa046121.56226078
16Acute myeloid leukemia_Homo sapiens_hsa052211.46700117
17Autoimmune thyroid disease_Homo sapiens_hsa053201.45180923
18Chemokine signaling pathway_Homo sapiens_hsa040621.37672757
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37204641
20Graft-versus-host disease_Homo sapiens_hsa053321.35841681
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.35338478
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32437892
23Herpes simplex infection_Homo sapiens_hsa051681.31205948
24Toxoplasmosis_Homo sapiens_hsa051451.31179019
25TNF signaling pathway_Homo sapiens_hsa046681.31110873
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.22971314
27* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.22954835
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.20389484
29Hepatitis B_Homo sapiens_hsa051611.18953827
30VEGF signaling pathway_Homo sapiens_hsa043701.18340241
31Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15455119
32NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14182562
33Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.13659137
34HTLV-I infection_Homo sapiens_hsa051661.13532691
35Linoleic acid metabolism_Homo sapiens_hsa005911.09783778
36Leukocyte transendothelial migration_Homo sapiens_hsa046701.08065537
37Regulation of autophagy_Homo sapiens_hsa041401.06711979
38Shigellosis_Homo sapiens_hsa051311.01606130
39Phototransduction_Homo sapiens_hsa047441.00521420
40Long-term potentiation_Homo sapiens_hsa047200.99565029
41Prolactin signaling pathway_Homo sapiens_hsa049170.98639946
42Influenza A_Homo sapiens_hsa051640.97492952
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96624532
44Circadian rhythm_Homo sapiens_hsa047100.95952848
45Chronic myeloid leukemia_Homo sapiens_hsa052200.94432971
46Cholinergic synapse_Homo sapiens_hsa047250.92607064
47Colorectal cancer_Homo sapiens_hsa052100.90425778
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.90014505
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.89105273
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88889937
51Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.88614928
52Platelet activation_Homo sapiens_hsa046110.88275611
53Pancreatic cancer_Homo sapiens_hsa052120.88068957
54Malaria_Homo sapiens_hsa051440.85639455
55MAPK signaling pathway_Homo sapiens_hsa040100.84891375
56Type I diabetes mellitus_Homo sapiens_hsa049400.84353549
57Dorso-ventral axis formation_Homo sapiens_hsa043200.83689926
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.80989030
59Neurotrophin signaling pathway_Homo sapiens_hsa047220.80247050
60Glycerolipid metabolism_Homo sapiens_hsa005610.79544271
61Apoptosis_Homo sapiens_hsa042100.79434056
62Glycerophospholipid metabolism_Homo sapiens_hsa005640.78935805
63Rap1 signaling pathway_Homo sapiens_hsa040150.73947889
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.73760092
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72195945
66Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71929972
67ABC transporters_Homo sapiens_hsa020100.69770724
68Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69523033
69Epstein-Barr virus infection_Homo sapiens_hsa051690.68874432
70Endocytosis_Homo sapiens_hsa041440.68168462
71Amphetamine addiction_Homo sapiens_hsa050310.67874608
72Taste transduction_Homo sapiens_hsa047420.67829501
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67639281
74Asthma_Homo sapiens_hsa053100.66989217
75Insulin secretion_Homo sapiens_hsa049110.66831047
76Nitrogen metabolism_Homo sapiens_hsa009100.66536821
77Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65306660
78Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62918030
79Oxytocin signaling pathway_Homo sapiens_hsa049210.61143285
80GABAergic synapse_Homo sapiens_hsa047270.61049561
81GnRH signaling pathway_Homo sapiens_hsa049120.60846933
82Hepatitis C_Homo sapiens_hsa051600.60498549
83Serotonergic synapse_Homo sapiens_hsa047260.60426638
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.58010221
85Notch signaling pathway_Homo sapiens_hsa043300.57786664
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.57641575
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57228683
88Choline metabolism in cancer_Homo sapiens_hsa052310.55919451
89Type II diabetes mellitus_Homo sapiens_hsa049300.55626386
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54477110
91Thyroid cancer_Homo sapiens_hsa052160.53711152
92cAMP signaling pathway_Homo sapiens_hsa040240.53228098
93African trypanosomiasis_Homo sapiens_hsa051430.53180570
94Renal cell carcinoma_Homo sapiens_hsa052110.52489352
95Salmonella infection_Homo sapiens_hsa051320.52197511
96Dopaminergic synapse_Homo sapiens_hsa047280.51648567
97Viral carcinogenesis_Homo sapiens_hsa052030.51383872
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51084705
99FoxO signaling pathway_Homo sapiens_hsa040680.50601760
100HIF-1 signaling pathway_Homo sapiens_hsa040660.50564825
101Calcium signaling pathway_Homo sapiens_hsa040200.50059890
102Tuberculosis_Homo sapiens_hsa051520.49626770
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.49422689
104Non-small cell lung cancer_Homo sapiens_hsa052230.48928809
105Inositol phosphate metabolism_Homo sapiens_hsa005620.48769753
106Insulin resistance_Homo sapiens_hsa049310.48413493
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48104693
108Circadian entrainment_Homo sapiens_hsa047130.47985383
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47320280
110Legionellosis_Homo sapiens_hsa051340.47152427
111Adherens junction_Homo sapiens_hsa045200.46819604
112Small cell lung cancer_Homo sapiens_hsa052220.44659207
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44617122
114cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43622805
115Renin secretion_Homo sapiens_hsa049240.43616976
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.42793465
117Morphine addiction_Homo sapiens_hsa050320.42071757
118Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40678575
119Cocaine addiction_Homo sapiens_hsa050300.40669714
120Glutamatergic synapse_Homo sapiens_hsa047240.40521742
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.40389804
122Salivary secretion_Homo sapiens_hsa049700.40300168
123Gastric acid secretion_Homo sapiens_hsa049710.40261205
124Rheumatoid arthritis_Homo sapiens_hsa053230.39911224
125Ras signaling pathway_Homo sapiens_hsa040140.39836035
126Nicotine addiction_Homo sapiens_hsa050330.39757508

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