TNFRSF19

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is highly expressed during embryonic development. It has been shown to interact with TRAF family members, and to activate JNK signaling pathway when overexpressed in cells. This receptor is capable of inducing apoptosis by a caspase-independent mechanism, and it is thought to play an essential role in embryonic development. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axonemal dynein complex assembly (GO:0070286)5.29312637
2layer formation in cerebral cortex (GO:0021819)5.06246912
3atrial cardiac muscle cell action potential (GO:0086014)4.89280275
4glial cell proliferation (GO:0014009)4.81628999
5cilium or flagellum-dependent cell motility (GO:0001539)4.75489928
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.68695446
7negative regulation of astrocyte differentiation (GO:0048712)4.65998185
8cilium movement (GO:0003341)4.53062910
9epithelial cilium movement (GO:0003351)4.28287446
10cellular response to cholesterol (GO:0071397)4.19187045
11response to auditory stimulus (GO:0010996)4.05548737
12membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.88299069
13lateral sprouting from an epithelium (GO:0060601)3.79062589
14locomotory exploration behavior (GO:0035641)3.77425978
15regulation of non-canonical Wnt signaling pathway (GO:2000050)3.76456327
16cerebral cortex neuron differentiation (GO:0021895)3.71113303
17glutamate secretion (GO:0014047)3.70405413
18negative regulation of oligodendrocyte differentiation (GO:0048715)3.61723180
19dendritic spine morphogenesis (GO:0060997)3.60533825
20regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.58641618
21motile cilium assembly (GO:0044458)3.57761717
22membrane repolarization (GO:0086009)3.56158884
23axonal fasciculation (GO:0007413)3.51672256
24positive regulation of smoothened signaling pathway (GO:0045880)3.49660325
25regulation of cardioblast differentiation (GO:0051890)3.48103383
26regulation of cardioblast proliferation (GO:0003264)3.47276466
27regulation of secondary heart field cardioblast proliferation (GO:0003266)3.47276466
28membrane repolarization during action potential (GO:0086011)3.47031745
29metanephric mesenchyme development (GO:0072075)3.46240889
30cellular response to sterol (GO:0036315)3.45795861
31planar cell polarity pathway involved in neural tube closure (GO:0090179)3.44994990
32establishment of tissue polarity (GO:0007164)3.44554875
33establishment of planar polarity (GO:0001736)3.44554875
34desmosome organization (GO:0002934)3.43105214
35synaptic vesicle maturation (GO:0016188)3.39777053
36negative regulation of glial cell differentiation (GO:0045686)3.39469302
37cardiac left ventricle morphogenesis (GO:0003214)3.34153993
38regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.30992544
39cellular potassium ion homeostasis (GO:0030007)3.27629746
40positive regulation of potassium ion transmembrane transport (GO:1901381)3.26937281
41limb development (GO:0060173)3.26872078
42appendage development (GO:0048736)3.26872078
43neurotransmitter-gated ion channel clustering (GO:0072578)3.26188654
44regulation of astrocyte differentiation (GO:0048710)3.24024002
45tonic smooth muscle contraction (GO:0014820)3.21587219
46chondrocyte proliferation (GO:0035988)3.19579968
47L-amino acid import (GO:0043092)3.18052741
48left/right pattern formation (GO:0060972)3.17982734
49muscle cell proliferation (GO:0033002)3.17924633
50cell proliferation involved in metanephros development (GO:0072203)3.17885265
51regulation of transforming growth factor beta2 production (GO:0032909)3.17672910
52kidney mesenchyme development (GO:0072074)3.17370632
53regulation of timing of cell differentiation (GO:0048505)3.17343870
54artery smooth muscle contraction (GO:0014824)3.16990764
55positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.15856966
56regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.11045123
57regulation of development, heterochronic (GO:0040034)3.10606341
58central nervous system projection neuron axonogenesis (GO:0021952)3.10119952
59cell proliferation involved in kidney development (GO:0072111)3.10073209
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.06024995
61sodium ion export (GO:0071436)3.03406818
62paraxial mesoderm development (GO:0048339)3.01978312
63chondroitin sulfate catabolic process (GO:0030207)3.01440959
64negative regulation of sodium ion transport (GO:0010766)2.98949362
65regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.98043825
66retinal rod cell development (GO:0046548)2.96191678
67negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.95895074
68lens fiber cell development (GO:0070307)2.95632653
69L-serine metabolic process (GO:0006563)2.93764104
70endocardial cushion morphogenesis (GO:0003203)2.92901061
71lung epithelium development (GO:0060428)2.91094272
72cerebral cortex radially oriented cell migration (GO:0021799)2.89967493
73auditory behavior (GO:0031223)2.88828648
74amino acid import (GO:0043090)2.87621749
75regulation of somitogenesis (GO:0014807)2.85451199
76cell communication by electrical coupling (GO:0010644)2.85156744
77axoneme assembly (GO:0035082)2.84625945
78epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.84123567
79negative regulation of catenin import into nucleus (GO:0035414)2.83834672
80regulation of heart morphogenesis (GO:2000826)2.82999713
81notochord development (GO:0030903)2.82307979
82vascular smooth muscle contraction (GO:0014829)2.82123869
83cochlea morphogenesis (GO:0090103)2.82122447
84mesenchymal cell proliferation (GO:0010463)2.81246397
85neuron recognition (GO:0008038)2.81182225
86long-term synaptic potentiation (GO:0060291)2.80551918
87G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.80523840
88cardiac myofibril assembly (GO:0055003)2.78517014
89C4-dicarboxylate transport (GO:0015740)2.77836495
90ephrin receptor signaling pathway (GO:0048013)2.76151196
91non-canonical Wnt signaling pathway (GO:0035567)2.75715895
92L-serine transport (GO:0015825)2.74580802
93cardiac muscle cell proliferation (GO:0060038)2.73177250
94regulation of respiratory system process (GO:0044065)2.72224932
95negative regulation of potassium ion transmembrane transport (GO:1901380)2.71250700
96synaptic vesicle exocytosis (GO:0016079)2.70796277
97vocalization behavior (GO:0071625)2.70254172
98mesenchyme morphogenesis (GO:0072132)2.69688016
99Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.69416898
100neuronal action potential propagation (GO:0019227)2.67020061
101vitamin transmembrane transport (GO:0035461)2.66962678
102spinal cord association neuron differentiation (GO:0021527)2.66890015
103positive regulation of gastrulation (GO:2000543)2.66143236
104regulation of membrane repolarization (GO:0060306)2.66096900
105regulation of glutamate receptor signaling pathway (GO:1900449)2.65920594
106regulation of potassium ion transmembrane transport (GO:1901379)2.65883021
107intraciliary transport (GO:0042073)2.65619795
108exploration behavior (GO:0035640)2.64939110
109alanine transport (GO:0032328)2.64828904
110neuron projection extension involved in neuron projection guidance (GO:1902284)2.63862291
111axon extension involved in axon guidance (GO:0048846)2.63862291
112dermatan sulfate biosynthetic process (GO:0030208)2.63431416
113oligodendrocyte differentiation (GO:0048709)2.63352169
114postsynaptic membrane organization (GO:0001941)2.62691495
115positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.60139774
116polarized epithelial cell differentiation (GO:0030859)2.59600420
117positive regulation of embryonic development (GO:0040019)2.59598517
118neuroblast proliferation (GO:0007405)2.59447663
119glial cell migration (GO:0008347)2.59113378
120positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.58918521
121regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.58711343
122lung-associated mesenchyme development (GO:0060484)2.58628190
123forebrain neuron differentiation (GO:0021879)2.58213341
124negative regulation of smoothened signaling pathway (GO:0045879)2.58171037
125regulation of dendritic spine morphogenesis (GO:0061001)2.57938438
126regulation of phospholipid biosynthetic process (GO:0071071)2.57780831
127regulation of Rac GTPase activity (GO:0032314)2.57675011
128generation of neurons (GO:0048699)2.56205392
129collagen fibril organization (GO:0030199)2.55013378
130positive regulation of cellular amide metabolic process (GO:0034250)2.54824461
131regulation of smoothened signaling pathway (GO:0008589)2.54758757
132regulation of axon guidance (GO:1902667)2.53785461
133peripheral nervous system axon ensheathment (GO:0032292)2.53349207
134myelination in peripheral nervous system (GO:0022011)2.53349207
135cilium organization (GO:0044782)2.53128231
136regulation of establishment of planar polarity (GO:0090175)2.52037766
137synaptic vesicle docking involved in exocytosis (GO:0016081)2.51759385
138negative chemotaxis (GO:0050919)2.50718457
139calcium-mediated signaling using intracellular calcium source (GO:0035584)2.50526756
140long-term memory (GO:0007616)2.50280492
141dendrite morphogenesis (GO:0048813)2.50162963
142convergent extension (GO:0060026)2.49895546
143innervation (GO:0060384)2.48725973
144cilium assembly (GO:0042384)2.48607557
145regulation of axon extension involved in axon guidance (GO:0048841)2.48473563
146negative regulation of hormone metabolic process (GO:0032351)2.47501939
147organ induction (GO:0001759)2.46503805
148negative regulation of protein localization to cell surface (GO:2000009)2.45747141
149regulation of organ formation (GO:0003156)2.44233427
150nephron tubule formation (GO:0072079)2.42925575
151regulation of mesenchymal cell proliferation (GO:0010464)2.42917010
152smooth muscle cell differentiation (GO:0051145)2.42586138
153positive regulation of mesenchymal cell proliferation (GO:0002053)2.42025274
154establishment of apical/basal cell polarity (GO:0035089)2.41802916
155cilium morphogenesis (GO:0060271)2.40946297
156outflow tract septum morphogenesis (GO:0003148)2.39067256
157regulation of cilium movement (GO:0003352)2.38135148
158embryonic foregut morphogenesis (GO:0048617)2.37713211
159head development (GO:0060322)2.37232185
160cardiac epithelial to mesenchymal transition (GO:0060317)2.37131780
161negative regulation of axon guidance (GO:1902668)2.36681932
162striated muscle cell proliferation (GO:0014855)2.36608649
163myofibril assembly (GO:0030239)2.36158754
164negative regulation of cytosolic calcium ion concentration (GO:0051481)2.34628462
165retinal ganglion cell axon guidance (GO:0031290)2.34185592
166dopaminergic neuron differentiation (GO:0071542)2.33599329
167left/right axis specification (GO:0070986)2.33255699
168embryonic retina morphogenesis in camera-type eye (GO:0060059)2.33213599
169establishment of monopolar cell polarity (GO:0061162)2.31365215
170establishment or maintenance of monopolar cell polarity (GO:0061339)2.31365215
171limb bud formation (GO:0060174)2.30720450
172positive regulation of odontogenesis (GO:0042482)2.29558114
173endocardial cushion development (GO:0003197)2.29471819
174lung lobe morphogenesis (GO:0060463)2.28543506
175craniofacial suture morphogenesis (GO:0097094)2.28060325
176cellular component assembly involved in morphogenesis (GO:0010927)2.26106674
177bone trabecula formation (GO:0060346)2.25970858
178embryonic cranial skeleton morphogenesis (GO:0048701)2.25361085
179forelimb morphogenesis (GO:0035136)2.25008855
180eye photoreceptor cell differentiation (GO:0001754)2.24798462
181photoreceptor cell differentiation (GO:0046530)2.24798462

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.88281842
2EED_16625203_ChIP-ChIP_MESCs_Mouse3.22357383
3JARID2_20064375_ChIP-Seq_MESCs_Mouse3.15878477
4* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse3.08593010
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08233610
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.98306907
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.98306907
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.92037049
9* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.87792827
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.80755072
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.64658155
12RNF2_27304074_Chip-Seq_ESCs_Mouse2.60986764
13* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58946908
14TP63_17297297_ChIP-ChIP_HaCaT_Human2.47622047
15AR_21572438_ChIP-Seq_LNCaP_Human2.34982145
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34008625
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33518610
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.30260244
19* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.22933943
20ERG_21242973_ChIP-ChIP_JURKAT_Human2.15151696
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.14142751
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.07495116
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.07053528
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.06254779
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.05637656
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.03421557
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.02201552
28EP300_21415370_ChIP-Seq_HL-1_Mouse1.99825422
29* CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.93873610
30TRIM28_21343339_ChIP-Seq_HEK293_Human1.91493772
31RING1B_27294783_Chip-Seq_ESCs_Mouse1.87253062
32ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83844499
33* TP53_20018659_ChIP-ChIP_R1E_Mouse1.81084329
34* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74692955
35PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.69776369
36* RING1B_27294783_Chip-Seq_NPCs_Mouse1.69126543
37GBX2_23144817_ChIP-Seq_PC3_Human1.67858415
38WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66733076
39DROSHA_22980978_ChIP-Seq_HELA_Human1.65823923
40WT1_19549856_ChIP-ChIP_CCG9911_Human1.63728369
41VDR_22108803_ChIP-Seq_LS180_Human1.61892261
42TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.61336594
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.57984732
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52603334
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.50754057
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49365364
47TAF15_26573619_Chip-Seq_HEK293_Human1.46892292
48PIAS1_25552417_ChIP-Seq_VCAP_Human1.45344053
49REST_21632747_ChIP-Seq_MESCs_Mouse1.44722769
50RARB_27405468_Chip-Seq_BRAIN_Mouse1.44347092
51* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.44120515
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43852132
53NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.43164431
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.43164431
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42391551
56* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42042399
57CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40894680
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40792920
59* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.40381798
60FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.38320624
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.38299415
62SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36444234
63RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36007068
64BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34405049
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.32947356
66IGF1R_20145208_ChIP-Seq_DFB_Human1.30023540
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.28018612
68RNF2_27304074_Chip-Seq_NSC_Mouse1.25680788
69RXR_22108803_ChIP-Seq_LS180_Human1.25109721
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.24629155
71REST_18959480_ChIP-ChIP_MESCs_Mouse1.24501805
72ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23577525
73* FOXA2_19822575_ChIP-Seq_HepG2_Human1.22647679
74GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22437000
75* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22380119
76STAT3_23295773_ChIP-Seq_U87_Human1.22174739
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.20874747
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20515495
79CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20382261
80TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19725534
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19715532
82CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19406701
83MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18354713
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15549665
85SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.14094058
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12897539
87CJUN_26792858_Chip-Seq_BT549_Human1.12474424
88EWS_26573619_Chip-Seq_HEK293_Human1.11354464
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11289254
90* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10433739
91TP53_18474530_ChIP-ChIP_U2OS_Human1.10151342
92* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09145646
93AHR_22903824_ChIP-Seq_MCF-7_Human1.08925230
94NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08644734
95AR_19668381_ChIP-Seq_PC3_Human1.08629769
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.08626182
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08438225
98TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08206399
99* SMAD3_21741376_ChIP-Seq_EPCs_Human1.08074757
100HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.08009943
101PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07681088
102LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07061521
103SALL1_21062744_ChIP-ChIP_HESCs_Human1.06992264
104AR_25329375_ChIP-Seq_VCAP_Human1.06681367
105BCAT_22108803_ChIP-Seq_LS180_Human1.05933777
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.05784810
107* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.05774867
108P300_19829295_ChIP-Seq_ESCs_Human1.05493058
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05414227
110TCF4_22108803_ChIP-Seq_LS180_Human1.05240741
111* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05178563
112* SOX2_21211035_ChIP-Seq_LN229_Gbm1.04774348
113* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04409314
114TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04090472
115ESR1_20079471_ChIP-ChIP_T-47D_Human1.02374678
116SMAD4_21799915_ChIP-Seq_A2780_Human1.02123018
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01383511
118ZNF274_21170338_ChIP-Seq_K562_Hela1.01092479
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99696068
120OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98909258
121* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.97729046
122SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97095704
123ESR2_21235772_ChIP-Seq_MCF-7_Human0.96217142
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.95947753
125TCF4_18268006_ChIP-ChIP_LS174T_Human0.95483184
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94029627
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93815574
128BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93033159
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.92983129
130OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92865986
131KDM2B_26808549_Chip-Seq_K562_Human0.92014692
132FUS_26573619_Chip-Seq_HEK293_Human0.92007372
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91665935
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91665935
135TP53_16413492_ChIP-PET_HCT116_Human0.91582635
136DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90527145
137SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89606238

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity3.77261965
2MP0000566_synostosis3.72839461
3MP0005503_abnormal_tendon_morphology3.44173012
4MP0008438_abnormal_cutaneous_collagen3.26751667
5MP0002254_reproductive_system_inflammat3.25837876
6MP0003136_yellow_coat_color2.95844250
7MP0004858_abnormal_nervous_system2.80786489
8MP0005275_abnormal_skin_tensile2.75149012
9MP0010030_abnormal_orbit_morphology2.67725818
10MP0002938_white_spotting2.45890094
11MP0009780_abnormal_chondrocyte_physiolo2.26595952
12MP0000537_abnormal_urethra_morphology2.13972158
13MP0003942_abnormal_urinary_system2.08239641
14MP0003635_abnormal_synaptic_transmissio2.07718004
15MP0002249_abnormal_larynx_morphology2.05908817
16MP0003880_abnormal_central_pattern2.04246048
17MP0009384_cardiac_valve_regurgitation2.04122481
18MP0003941_abnormal_skin_development1.98303045
19MP0000778_abnormal_nervous_system1.98135191
20MP0000049_abnormal_middle_ear1.94482956
21MP0001486_abnormal_startle_reflex1.85202559
22MP0004233_abnormal_muscle_weight1.80879559
23MP0001346_abnormal_lacrimal_gland1.75872106
24MP0005645_abnormal_hypothalamus_physiol1.74506368
25MP0002638_abnormal_pupillary_reflex1.71141511
26MP0002063_abnormal_learning/memory/cond1.69678334
27MP0002108_abnormal_muscle_morphology1.65540302
28MP0000579_abnormal_nail_morphology1.65502322
29MP0000647_abnormal_sebaceous_gland1.65125003
30MP0003705_abnormal_hypodermis_morpholog1.58036558
31MP0000534_abnormal_ureter_morphology1.54498688
32MP0003329_amyloid_beta_deposits1.47633021
33MP0004885_abnormal_endolymph1.46923856
34MP0002233_abnormal_nose_morphology1.45694619
35MP0000026_abnormal_inner_ear1.45084267
36MP0005646_abnormal_pituitary_gland1.42204061
37MP0009250_abnormal_appendicular_skeleto1.41650692
38MP0008789_abnormal_olfactory_epithelium1.39281297
39MP0005408_hypopigmentation1.36843173
40MP0000762_abnormal_tongue_morphology1.36780113
41MP0003938_abnormal_ear_development1.36735581
42MP0000428_abnormal_craniofacial_morphol1.36470672
43MP0004270_analgesia1.36084823
44MP0003011_delayed_dark_adaptation1.35838716
45MP0002102_abnormal_ear_morphology1.35262579
46MP0006292_abnormal_olfactory_placode1.34190969
47MP0003283_abnormal_digestive_organ1.31158877
48MP0005394_taste/olfaction_phenotype1.31042390
49MP0005499_abnormal_olfactory_system1.31042390
50MP0003937_abnormal_limbs/digits/tail_de1.30392686
51MP0009053_abnormal_anal_canal1.30220976
52MP0002557_abnormal_social/conspecific_i1.29113763
53MP0002572_abnormal_emotion/affect_behav1.28268648
54MP0009745_abnormal_behavioral_response1.27387596
55MP0002282_abnormal_trachea_morphology1.27063497
56MP0005248_abnormal_Harderian_gland1.26289190
57MP0001958_emphysema1.26031624
58MP0000383_abnormal_hair_follicle1.25244935
59MP0002064_seizures1.24412285
60MP0009379_abnormal_foot_pigmentation1.23448595
61MP0003861_abnormal_nervous_system1.20944300
62MP0002116_abnormal_craniofacial_bone1.19809668
63MP0005187_abnormal_penis_morphology1.18954808
64MP0003755_abnormal_palate_morphology1.18364656
65MP0002697_abnormal_eye_size1.18255634
66MP0000372_irregular_coat_pigmentation1.17743989
67MP0001984_abnormal_olfaction1.17525244
68MP0010678_abnormal_skin_adnexa1.17013262
69MP0002098_abnormal_vibrissa_morphology1.16719900
70MP0005377_hearing/vestibular/ear_phenot1.16497729
71MP0003878_abnormal_ear_physiology1.16497729
72MP0004084_abnormal_cardiac_muscle1.16064064
73MP0003122_maternal_imprinting1.15720449
74MP0002837_dystrophic_cardiac_calcinosis1.15222814
75MP0002184_abnormal_innervation1.14721936
76MP0003385_abnormal_body_wall1.14659766
77MP0000613_abnormal_salivary_gland1.14305615
78MP0000955_abnormal_spinal_cord1.13829787
79MP0002109_abnormal_limb_morphology1.13490629
80MP0000462_abnormal_digestive_system1.12609923
81MP0008569_lethality_at_weaning1.11572518
82MP0005257_abnormal_intraocular_pressure1.11424469
83MP0003690_abnormal_glial_cell1.10523833
84MP0005423_abnormal_somatic_nervous1.10465580
85MP0000631_abnormal_neuroendocrine_gland1.09186427
86MP0002152_abnormal_brain_morphology1.09130888
87MP0002882_abnormal_neuron_morphology1.07934946
88MP0003935_abnormal_craniofacial_develop1.07315451
89MP0004272_abnormal_basement_membrane1.06426699
90MP0002932_abnormal_joint_morphology1.06021403
91MP0001879_abnormal_lymphatic_vessel1.05082693
92MP0010368_abnormal_lymphatic_system1.04014060
93MP0002090_abnormal_vision1.03865232
94MP0002734_abnormal_mechanical_nocicepti1.02643856
95MP0000467_abnormal_esophagus_morphology1.01763668
96MP0003115_abnormal_respiratory_system1.00902917
97MP0002234_abnormal_pharynx_morphology1.00317786
98MP0001299_abnormal_eye_distance/1.00053497
99MP0001340_abnormal_eyelid_morphology0.99833712
100MP0002909_abnormal_adrenal_gland0.99151614
101MP0001177_atelectasis0.99000486
102MP0000733_abnormal_muscle_development0.98231547
103MP0001963_abnormal_hearing_physiology0.97863054
104MP0001293_anophthalmia0.97712857
105MP0010234_abnormal_vibrissa_follicle0.97686392
106MP0003879_abnormal_hair_cell0.96811183
107MP0003634_abnormal_glial_cell0.96215612
108MP0003567_abnormal_fetal_cardiomyocyte0.96033968
109MP0001485_abnormal_pinna_reflex0.95438689
110MP0005197_abnormal_uvea_morphology0.95240142
111MP0003890_abnormal_embryonic-extraembry0.94211305
112MP0000427_abnormal_hair_cycle0.93944680
113MP0003119_abnormal_digestive_system0.93135340
114MP0001270_distended_abdomen0.92673834
115MP0000163_abnormal_cartilage_morphology0.91567300
116MP0000432_abnormal_head_morphology0.91423352
117MP0005623_abnormal_meninges_morphology0.90555671
118MP0006054_spinal_hemorrhage0.89973992
119MP0002115_abnormal_skeleton_extremities0.89768610
120MP0002896_abnormal_bone_mineralization0.89164088
121MP0003950_abnormal_plasma_membrane0.88707299
122MP0004215_abnormal_myocardial_fiber0.87778682
123MP0002111_abnormal_tail_morphology0.86859363
124MP0005551_abnormal_eye_electrophysiolog0.86194020
125MP0005253_abnormal_eye_physiology0.86150397
126MP0002653_abnormal_ependyma_morphology0.85397332
127MP0001286_abnormal_eye_development0.84512352
128MP0003137_abnormal_impulse_conducting0.83717030
129MP0002272_abnormal_nervous_system0.82558818
130MP0000751_myopathy0.82492254
131MP0001440_abnormal_grooming_behavior0.82429376
132MP0005508_abnormal_skeleton_morphology0.82001274
133MP0000516_abnormal_urinary_system0.81916512
134MP0005367_renal/urinary_system_phenotyp0.81916512
135MP0005171_absent_coat_pigmentation0.81305306
136MP0004133_heterotaxia0.80812803
137MP0005391_vision/eye_phenotype0.80657826
138MP0002092_abnormal_eye_morphology0.80565377
139MP0001968_abnormal_touch/_nociception0.80065977
140MP0002752_abnormal_somatic_nervous0.79707747
141MP0002067_abnormal_sensory_capabilities0.79689465
142MP0002114_abnormal_axial_skeleton0.75303137
143MP0000639_abnormal_adrenal_gland0.74210442
144MP0001324_abnormal_eye_pigmentation0.73792466
145MP0003279_aneurysm0.71139473
146MP0002089_abnormal_postnatal_growth/wei0.70895212

Predicted human phenotypes

RankGene SetZ-score
1Megalencephaly (HP:0001355)6.49689667
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.64781146
3Abnormal respiratory epithelium morphology (HP:0012253)4.46706613
4Abnormal respiratory motile cilium morphology (HP:0005938)4.46706613
5Abnormal ciliary motility (HP:0012262)4.39241404
6Abnormal respiratory motile cilium physiology (HP:0012261)4.26235670
7Aplasia involving bones of the upper limbs (HP:0009823)4.22743147
8Aplasia of the phalanges of the hand (HP:0009802)4.22743147
9Aplasia involving bones of the extremities (HP:0009825)4.22743147
10Rhinitis (HP:0012384)4.21509035
11Absent/shortened dynein arms (HP:0200106)4.08295725
12Dynein arm defect of respiratory motile cilia (HP:0012255)4.08295725
13Calcaneovalgus deformity (HP:0001848)3.28981723
14Occipital encephalocele (HP:0002085)3.09554992
15Aortic dissection (HP:0002647)2.97398896
16Deformed tarsal bones (HP:0008119)2.95019699
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.84842683
18Short 4th metacarpal (HP:0010044)2.84842683
19True hermaphroditism (HP:0010459)2.75031765
20Morphological abnormality of the middle ear (HP:0008609)2.73797846
21Neonatal short-limb short stature (HP:0008921)2.71555217
22Ankyloglossia (HP:0010296)2.70220393
23Neurofibrillary tangles (HP:0002185)2.65623167
24Pancreatic fibrosis (HP:0100732)2.64304269
25Abnormality of dentin (HP:0010299)2.63794953
26Absent eyelashes (HP:0000561)2.59556576
27Coronal craniosynostosis (HP:0004440)2.58382503
28Long nose (HP:0003189)2.56209293
29Protrusio acetabuli (HP:0003179)2.54231202
30Bronchomalacia (HP:0002780)2.53129510
31Absent hair (HP:0002298)2.52202442
32Shallow orbits (HP:0000586)2.47686909
33Hepatoblastoma (HP:0002884)2.42961954
34Cerebral inclusion bodies (HP:0100314)2.42352026
35Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.36848192
36Myokymia (HP:0002411)2.35029616
37Premature rupture of membranes (HP:0001788)2.31200058
38Soft skin (HP:0000977)2.29408477
39Midline defect of the nose (HP:0004122)2.28475286
40Alacrima (HP:0000522)2.26862671
41Cutaneous syndactyly (HP:0012725)2.26537443
42Cutaneous finger syndactyly (HP:0010554)2.26186118
43Increased number of teeth (HP:0011069)2.25835789
44Bronchiectasis (HP:0002110)2.25239378
45Epileptic encephalopathy (HP:0200134)2.25182768
46Abnormality of the axillary hair (HP:0100134)2.24408647
47Abnormality of secondary sexual hair (HP:0009888)2.24408647
48Cystic liver disease (HP:0006706)2.23190761
49Abnormality of molar (HP:0011077)2.22470326
50Abnormality of molar morphology (HP:0011070)2.22470326
51Abnormality of the dental root (HP:0006486)2.22285798
52Taurodontia (HP:0000679)2.22285798
53Abnormality of permanent molar morphology (HP:0011071)2.22285798
54Partial duplication of the phalanx of hand (HP:0009999)2.22014426
55Aplasia/Hypoplasia of the sternum (HP:0006714)2.19038843
56Chronic bronchitis (HP:0004469)2.19024507
57Pancreatic cysts (HP:0001737)2.18344317
58Arterial tortuosity (HP:0005116)2.15686221
59Partial duplication of thumb phalanx (HP:0009944)2.14330158
60Focal motor seizures (HP:0011153)2.10507264
61Synostosis of carpal bones (HP:0005048)2.08236308
62Abnormality of the middle phalanges of the toes (HP:0010183)2.07781559
63Hypoplastic labia majora (HP:0000059)2.06862747
64Abnormality of the dental pulp (HP:0006479)2.06034760
65Decreased lacrimation (HP:0000633)2.05380234
66Abnormality of the antihelix (HP:0009738)2.04559510
67Synostosis involving the elbow (HP:0003938)2.01959522
68Humeroradial synostosis (HP:0003041)2.01959522
69Adactyly (HP:0009776)2.01749570
70Onycholysis (HP:0001806)2.01677457
71Abnormality of the 4th metacarpal (HP:0010012)2.01569219
72Wide anterior fontanel (HP:0000260)2.01334868
73Broad toe (HP:0001837)2.00886180
74Aplasia of the musculature (HP:0100854)2.00854510
75Mixed hearing impairment (HP:0000410)2.00136213
76Postaxial foot polydactyly (HP:0001830)2.00098102
77Lip pit (HP:0100267)1.97816181
78Nephronophthisis (HP:0000090)1.93714282
79Abnormality of oral frenula (HP:0000190)1.92774765
80Diplopia (HP:0000651)1.92740272
81Abnormality of binocular vision (HP:0011514)1.92740272
82Abnormality of the lacrimal duct (HP:0011481)1.92466755
83Preaxial foot polydactyly (HP:0001841)1.91510501
84Narrow nasal bridge (HP:0000446)1.91248902
85Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.91180080
86Absent epiphyses (HP:0010577)1.91180080
87Limited hip movement (HP:0008800)1.89792807
88Anophthalmia (HP:0000528)1.89732421
89Abnormality of the ischium (HP:0003174)1.88803618
90Pterygium (HP:0001059)1.88429531
91Aplasia/Hypoplasia of the tongue (HP:0010295)1.88153974
92Follicular hyperkeratosis (HP:0007502)1.86640308
93Split foot (HP:0001839)1.85456856
94Hemiparesis (HP:0001269)1.84465641
95Hypoplastic ischia (HP:0003175)1.84199652
96Genital tract atresia (HP:0001827)1.83912695
97Abnormality of the nasolacrimal system (HP:0000614)1.82973711
98Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.82658197
99Absent eyebrow (HP:0002223)1.82454194
100Broad hallux (HP:0010055)1.81875969
101Clumsiness (HP:0002312)1.81462037
102Abnormality of the labia majora (HP:0012881)1.81409695
103Choanal stenosis (HP:0000452)1.80636949
104Bell-shaped thorax (HP:0001591)1.80421525
105Renal duplication (HP:0000075)1.80389537
106Broad palm (HP:0001169)1.78839393
107Vaginal atresia (HP:0000148)1.78565097
108Bladder diverticulum (HP:0000015)1.78204831
109Short hallux (HP:0010109)1.78128798
110Pulmonary artery stenosis (HP:0004415)1.77922162
111Fragile nails (HP:0001808)1.77367874
112Mesangial abnormality (HP:0001966)1.77010672
113Back pain (HP:0003418)1.76983380
114Neoplasm of the heart (HP:0100544)1.76360443
115Abnormality of the labia minora (HP:0012880)1.76175212
116Bifid tongue (HP:0010297)1.75459070
117Abnormality of the calcaneus (HP:0008364)1.74099199
118Vascular tortuosity (HP:0004948)1.74095399
119Recurrent corneal erosions (HP:0000495)1.70263512
120Stenosis of the external auditory canal (HP:0000402)1.69402356
121Abnormality of the phalanges of the 2nd finger (HP:0009541)1.69389215
122Abnormality of the renal medulla (HP:0100957)1.68170293
123Labial hypoplasia (HP:0000066)1.67231604
124Abnormality of the pubic bones (HP:0003172)1.66940541
125Medial flaring of the eyebrow (HP:0010747)1.66758675
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.66686589
127Blue irides (HP:0000635)1.65982427
128Omphalocele (HP:0001539)1.65021460
129Bilateral microphthalmos (HP:0007633)1.64915826
130Abnormality of midbrain morphology (HP:0002418)1.64780219
131Molar tooth sign on MRI (HP:0002419)1.64780219
132Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64662220
133Right ventricular cardiomyopathy (HP:0011663)1.64627966
134Pseudobulbar signs (HP:0002200)1.62670963
135Vitreoretinal degeneration (HP:0000655)1.62372093
136Aplasia cutis congenita (HP:0001057)1.62258430
137Bifid scrotum (HP:0000048)1.62204414
138Turricephaly (HP:0000262)1.61734525
139Hypoplastic left heart (HP:0004383)1.59948836
140Preauricular pit (HP:0004467)1.59691122
141Periauricular skin pits (HP:0100277)1.59691122
142Nasolacrimal duct obstruction (HP:0000579)1.59139790
143Congenital primary aphakia (HP:0007707)1.59115733
144Abnormality of the calf musculature (HP:0001430)1.59027292
145Thickened helices (HP:0000391)1.58746916
146Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.58343730
147Broad alveolar ridges (HP:0000187)1.58293495
148Abnormality of the diencephalon (HP:0010662)1.57793661
149Broad metatarsal (HP:0001783)1.57352451
150Concave nail (HP:0001598)1.57130941
151Small epiphyses (HP:0010585)1.56989636
152Gait imbalance (HP:0002141)1.56890927
153Abnormality of the parietal bone (HP:0002696)1.56880677
154Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.56197816
155Skull defect (HP:0001362)1.55854476
156Absent toe (HP:0010760)1.55843753
157Postaxial hand polydactyly (HP:0001162)1.55744679
158Tarsal synostosis (HP:0008368)1.55716737
159Epiphyseal dysplasia (HP:0002656)1.55567395
160Skin pits (HP:0100276)1.55177158
161Chronic hepatic failure (HP:0100626)1.54803417
162Ectopic anus (HP:0004397)1.54716639
163Mitral valve prolapse (HP:0001634)1.54574477
164Synostosis involving bones of the feet (HP:0009140)1.54563104
165Synostosis involving bones of the lower limbs (HP:0009138)1.54563104

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.47856458
2EPHA44.90927410
3NTRK24.31470357
4PRKD33.73642930
5STK38L3.38224064
6SIK13.25880441
7PHKG23.12738639
8PHKG13.12738639
9MAPK152.95056909
10TRIB32.78542330
11FRK2.69640120
12EPHB22.57741826
13NTRK32.32055161
14KSR12.25455250
15DDR22.14074518
16STK392.01650210
17STK241.96174730
18NEK91.78061744
19PNCK1.73519628
20FGFR21.73284567
21MARK11.66629598
22PKN21.58331253
23ICK1.54266872
24MINK11.52965196
25STK31.50251095
26WNK41.45679259
27MAP3K91.39812349
28NTRK11.38879039
29LATS11.36420162
30CASK1.35262618
31LATS21.25349042
32MAP3K101.21483555
33KSR21.20549945
34MAPK131.19499987
35PAK31.19434762
36SGK21.18930445
37FGR1.18645288
38TRPM71.16466543
39SIK31.14225684
40TYRO31.12656964
41DAPK21.10955342
42TGFBR11.10627317
43SGK2231.10299731
44SGK4941.10299731
45MYLK1.09306934
46PDGFRA1.08279852
47GRK11.08193998
48LRRK21.06973378
49PLK21.05956900
50WEE11.05668059
51PAK61.03805800
52MAPKAPK30.96688694
53BMPR1B0.96597287
54CDK50.96082910
55BRSK20.95600180
56SIK20.95075038
57FGFR40.93904466
58PIK3CA0.92551800
59ERBB40.91279180
60SGK30.90437124
61FGFR10.86753581
62NUAK10.85135317
63ERBB20.84695309
64OBSCN0.84420784
65CAMK1G0.83005485
66TAF10.81205078
67MAP3K40.80980662
68FLT30.80810591
69WNK30.80494170
70NME10.79055778
71PRKCG0.74268864
72EPHA30.71636486
73PTK20.71420584
74NLK0.71032183
75ADRBK20.70039109
76CCNB10.69909756
77CDK80.68812942
78DMPK0.66365228
79EPHA20.65429539
80CAMKK10.63573315
81WNK10.63351304
82ROCK20.62528463
83GRK60.62426973
84PTK60.61289714
85RET0.58622906
86MAPK120.57234237
87NEK20.57068342
88CDK180.56778396
89ROCK10.56643094
90TNIK0.56286713
91PAK20.56088726
92BCR0.55233192
93FER0.54670525
94PRKAA20.54175572
95STK380.53922936
96MAPK70.52916810
97DYRK1A0.52425780
98CDK140.52369372
99SGK10.52010691
100PRKCH0.51613287
101CDK150.51473565
102MAP3K20.50383755
103ERBB30.49137548
104MARK20.48464730
105AKT30.48116967
106MELK0.47952792
107INSRR0.46878654
108DYRK1B0.46228040
109MAPKAPK50.46102193
110PRKD20.45286763
111UHMK10.43369937
112PDGFRB0.43167104
113PTK2B0.42830772
114MKNK20.42801179
115BMX0.42672463
116BRSK10.41905335
117CDK11A0.41735680
118MAP3K70.41495187
119CDC42BPA0.40146923
120GSK3A0.39950091
121RAF10.38284659
122NEK60.37720958
123PRKAA10.37651340
124EEF2K0.36749805
125ILK0.36667657
126MAP2K10.36000759
127DAPK10.35795065
128FYN0.35672572
129PRKCE0.35218671
130ADRBK10.34653358
131NEK10.34639202
132SRC0.34591165
133CSNK1G10.34566286
134AKT20.34519213
135MAP2K40.34178840
136PKN10.33658027
137RPS6KA30.33335191
138MKNK10.33109148
139MTOR0.32651641
140CSNK1A1L0.30024852
141CDK30.29983875
142PRKCZ0.29741799
143CAMK2A0.29286388
144RPS6KB10.28502110
145TAOK10.28216672
146PRKD10.27930963
147MAP3K130.26971582
148FGFR30.24988678
149PLK30.22613211
150RIPK10.21980592
151MET0.21153053

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.26437110
2Basal cell carcinoma_Homo sapiens_hsa052172.86890955
3Fatty acid biosynthesis_Homo sapiens_hsa000612.53823165
4Histidine metabolism_Homo sapiens_hsa003402.34931218
5Nicotine addiction_Homo sapiens_hsa050332.31456354
6Glutamatergic synapse_Homo sapiens_hsa047242.05185375
7Melanogenesis_Homo sapiens_hsa049161.95359563
8Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.90134934
9Hedgehog signaling pathway_Homo sapiens_hsa043401.89872491
10Hippo signaling pathway_Homo sapiens_hsa043901.88458375
11Circadian entrainment_Homo sapiens_hsa047131.85939703
12Axon guidance_Homo sapiens_hsa043601.85639787
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79168505
14Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.74785711
15GABAergic synapse_Homo sapiens_hsa047271.71810792
16Complement and coagulation cascades_Homo sapiens_hsa046101.70282531
17Salivary secretion_Homo sapiens_hsa049701.69233506
18Wnt signaling pathway_Homo sapiens_hsa043101.66683716
19Gastric acid secretion_Homo sapiens_hsa049711.66381219
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65530433
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.54594829
22Long-term potentiation_Homo sapiens_hsa047201.52980718
23Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52006760
24Fatty acid metabolism_Homo sapiens_hsa012121.51494636
25Amphetamine addiction_Homo sapiens_hsa050311.45632529
26Olfactory transduction_Homo sapiens_hsa047401.44968830
27Morphine addiction_Homo sapiens_hsa050321.44877941
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.44679036
29Insulin secretion_Homo sapiens_hsa049111.44569836
30ABC transporters_Homo sapiens_hsa020101.42042349
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.41781609
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.38998975
33Phenylalanine metabolism_Homo sapiens_hsa003601.37894553
34Tyrosine metabolism_Homo sapiens_hsa003501.35973479
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34714217
36Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34511592
37Dopaminergic synapse_Homo sapiens_hsa047281.28888288
38beta-Alanine metabolism_Homo sapiens_hsa004101.28616108
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26256866
40Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25644566
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.23985627
42Lysine degradation_Homo sapiens_hsa003101.20597615
43Cholinergic synapse_Homo sapiens_hsa047251.19970814
44Steroid biosynthesis_Homo sapiens_hsa001001.19209347
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.19061036
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.18379005
47Glioma_Homo sapiens_hsa052141.17804885
48Renin secretion_Homo sapiens_hsa049241.16488957
49Calcium signaling pathway_Homo sapiens_hsa040201.16366217
50Gap junction_Homo sapiens_hsa045401.16268655
51Cocaine addiction_Homo sapiens_hsa050301.15942252
52Chemical carcinogenesis_Homo sapiens_hsa052041.15925765
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15020163
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.13926442
55Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12737278
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11534634
57Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10237472
58Long-term depression_Homo sapiens_hsa047301.10140564
59Oxytocin signaling pathway_Homo sapiens_hsa049211.08044455
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.06682511
61Estrogen signaling pathway_Homo sapiens_hsa049151.04772861
62Sphingolipid metabolism_Homo sapiens_hsa006001.03644030
63cAMP signaling pathway_Homo sapiens_hsa040241.02223040
64Dorso-ventral axis formation_Homo sapiens_hsa043201.00521850
65Circadian rhythm_Homo sapiens_hsa047100.99499911
66Vitamin digestion and absorption_Homo sapiens_hsa049770.98073482
67Adherens junction_Homo sapiens_hsa045200.97451439
68TGF-beta signaling pathway_Homo sapiens_hsa043500.96305638
69GnRH signaling pathway_Homo sapiens_hsa049120.95734745
70Notch signaling pathway_Homo sapiens_hsa043300.95021661
71Proteoglycans in cancer_Homo sapiens_hsa052050.94129776
72Glucagon signaling pathway_Homo sapiens_hsa049220.92523727
73Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91920318
74Rap1 signaling pathway_Homo sapiens_hsa040150.91077931
75Glycosaminoglycan degradation_Homo sapiens_hsa005310.90592687
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90530768
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.89468497
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88562881
79Fatty acid degradation_Homo sapiens_hsa000710.86958129
80Synaptic vesicle cycle_Homo sapiens_hsa047210.86570477
81Tight junction_Homo sapiens_hsa045300.86480603
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86341534
83Linoleic acid metabolism_Homo sapiens_hsa005910.86241149
84ErbB signaling pathway_Homo sapiens_hsa040120.85269910
85Endometrial cancer_Homo sapiens_hsa052130.85257849
86Ether lipid metabolism_Homo sapiens_hsa005650.84857676
87Colorectal cancer_Homo sapiens_hsa052100.83354694
88Dilated cardiomyopathy_Homo sapiens_hsa054140.82816625
89Bile secretion_Homo sapiens_hsa049760.82135886
90N-Glycan biosynthesis_Homo sapiens_hsa005100.79273575
91Tryptophan metabolism_Homo sapiens_hsa003800.78321517
92Oocyte meiosis_Homo sapiens_hsa041140.77748586
93Phospholipase D signaling pathway_Homo sapiens_hsa040720.77343115
94ECM-receptor interaction_Homo sapiens_hsa045120.76470337
95Protein export_Homo sapiens_hsa030600.76168180
96Glutathione metabolism_Homo sapiens_hsa004800.75488104
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.73887004
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.73478524
99MicroRNAs in cancer_Homo sapiens_hsa052060.73308812
100Serotonergic synapse_Homo sapiens_hsa047260.72721700
101Arginine and proline metabolism_Homo sapiens_hsa003300.71463957
102Cardiac muscle contraction_Homo sapiens_hsa042600.71186565
103Small cell lung cancer_Homo sapiens_hsa052220.70832685
104Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70416505
105Mineral absorption_Homo sapiens_hsa049780.69875481
106Choline metabolism in cancer_Homo sapiens_hsa052310.69462420
107Butanoate metabolism_Homo sapiens_hsa006500.69103307
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67634392
109Thyroid hormone synthesis_Homo sapiens_hsa049180.67151698
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66775902
111Phototransduction_Homo sapiens_hsa047440.66575784
112Focal adhesion_Homo sapiens_hsa045100.65999184
113Pancreatic secretion_Homo sapiens_hsa049720.64801626
114Protein digestion and absorption_Homo sapiens_hsa049740.64422063
115Retinol metabolism_Homo sapiens_hsa008300.63837486
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62842580
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.61598696
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60738899
119Renal cell carcinoma_Homo sapiens_hsa052110.59656514
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.59395578
121Melanoma_Homo sapiens_hsa052180.58815433
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.58618613
123mTOR signaling pathway_Homo sapiens_hsa041500.58060400
124Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57828504
125Taste transduction_Homo sapiens_hsa047420.57341247
126Huntingtons disease_Homo sapiens_hsa050160.56731695
127Peroxisome_Homo sapiens_hsa041460.55281441
128Prostate cancer_Homo sapiens_hsa052150.54835444
129Amoebiasis_Homo sapiens_hsa051460.54693981
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.53463745
131Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.53451741
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52639277
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52224072
134Pathways in cancer_Homo sapiens_hsa052000.52207855
135Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51693140
136Ovarian steroidogenesis_Homo sapiens_hsa049130.51473723
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50503939
138Ras signaling pathway_Homo sapiens_hsa040140.50317428
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.49061063
140Bladder cancer_Homo sapiens_hsa052190.48601484
141Non-small cell lung cancer_Homo sapiens_hsa052230.48228259
142Propanoate metabolism_Homo sapiens_hsa006400.48029612
143VEGF signaling pathway_Homo sapiens_hsa043700.47882543
144Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47296464
145Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45726937
146Insulin resistance_Homo sapiens_hsa049310.45612066
147Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45254956
148Pyruvate metabolism_Homo sapiens_hsa006200.44753203
149MAPK signaling pathway_Homo sapiens_hsa040100.44299188
150PPAR signaling pathway_Homo sapiens_hsa033200.44128803
151Insulin signaling pathway_Homo sapiens_hsa049100.43726295

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