TNFRSF10D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cell adhesion mediated by integrin (GO:0033627)6.29123635
2wound healing, spreading of epidermal cells (GO:0035313)5.89932339
3chondrocyte proliferation (GO:0035988)5.53374973
4endodermal cell differentiation (GO:0035987)5.52046186
5skin morphogenesis (GO:0043589)5.02120644
6hemidesmosome assembly (GO:0031581)4.70100637
7wound healing, spreading of cells (GO:0044319)4.59559914
8mesodermal cell differentiation (GO:0048333)4.41185425
9substrate-dependent cell migration (GO:0006929)4.41075639
10cell-substrate junction assembly (GO:0007044)4.07284464
11protein localization to endosome (GO:0036010)3.94308875
12retina vasculature morphogenesis in camera-type eye (GO:0061299)3.84024394
13cell migration involved in sprouting angiogenesis (GO:0002042)3.78393650
14hyaluronan catabolic process (GO:0030214)3.68937555
15positive regulation of endothelial cell apoptotic process (GO:2000353)3.68562949
16lymphangiogenesis (GO:0001946)3.67422921
17collagen fibril organization (GO:0030199)3.65738762
18positive regulation of p38MAPK cascade (GO:1900745)3.58210684
19basement membrane organization (GO:0071711)3.56156509
20blood vessel maturation (GO:0001955)3.44736805
21endothelial cell morphogenesis (GO:0001886)3.42221563
22Golgi transport vesicle coating (GO:0048200)3.41985805
23COPI coating of Golgi vesicle (GO:0048205)3.41985805
24sprouting angiogenesis (GO:0002040)3.41215329
25negative regulation of chondrocyte differentiation (GO:0032331)3.40500773
26heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.37716838
27positive regulation of blood vessel endothelial cell migration (GO:0043536)3.34815397
28positive regulation of osteoblast proliferation (GO:0033690)3.28625915
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.26252301
30collagen metabolic process (GO:0032963)3.24748622
31negative regulation of fibrinolysis (GO:0051918)3.23449600
32mammary gland epithelial cell proliferation (GO:0033598)3.21200160
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.19936541
34positive regulation of astrocyte differentiation (GO:0048711)3.15097975
35blood vessel endothelial cell migration (GO:0043534)3.14106714
36adherens junction assembly (GO:0034333)3.13406284
37collagen catabolic process (GO:0030574)3.12252827
38positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.11937527
39hypotonic response (GO:0006971)3.09558983
40stress fiber assembly (GO:0043149)3.06434727
41protein heterotrimerization (GO:0070208)3.04857018
42COPII vesicle coating (GO:0048208)3.04115829
43protein retention in ER lumen (GO:0006621)3.03224744
44negative regulation of anoikis (GO:2000811)3.03008396
45extracellular matrix disassembly (GO:0022617)3.01172443
46cellular response to vitamin (GO:0071295)3.00014366
47dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.99496084
48vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.98506069
49protein hydroxylation (GO:0018126)2.97330555
50multicellular organismal macromolecule metabolic process (GO:0044259)2.94851712
51regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.94519630
52cellular response to vitamin D (GO:0071305)2.93172081
53negative regulation of smooth muscle cell migration (GO:0014912)2.92679091
54focal adhesion assembly (GO:0048041)2.92080000
55cell-substrate adherens junction assembly (GO:0007045)2.92080000
56pathway-restricted SMAD protein phosphorylation (GO:0060389)2.90187157
57vascular endothelial growth factor signaling pathway (GO:0038084)2.90000043
58Notch signaling involved in heart development (GO:0061314)2.88763877
59trophoblast giant cell differentiation (GO:0060707)2.88553966
60kidney mesenchyme development (GO:0072074)2.87724522
61sequestering of extracellular ligand from receptor (GO:0035581)2.84447377
62atrioventricular valve morphogenesis (GO:0003181)2.83796496
63regulation of transforming growth factor beta2 production (GO:0032909)2.83040572
64endocardial cushion development (GO:0003197)2.82611956
65positive regulation of cartilage development (GO:0061036)2.82237616
66regulation of plasminogen activation (GO:0010755)2.81288673
67regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.80201301
68multicellular organismal catabolic process (GO:0044243)2.79717351
69endothelium development (GO:0003158)2.78353981
70multicellular organismal metabolic process (GO:0044236)2.78038497
71substrate adhesion-dependent cell spreading (GO:0034446)2.77313018
72bone trabecula formation (GO:0060346)2.74379522
73type B pancreatic cell proliferation (GO:0044342)2.73977546
74decidualization (GO:0046697)2.70167490
75positive regulation of endothelial cell migration (GO:0010595)2.68025582
76membrane protein ectodomain proteolysis (GO:0006509)2.67489880
77positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.64892861
78chondrocyte development (GO:0002063)2.64389283
79chondroitin sulfate biosynthetic process (GO:0030206)2.63742237
80positive regulation of epithelial to mesenchymal transition (GO:0010718)2.63178517
81mesenchymal-epithelial cell signaling (GO:0060638)2.62827040
82positive regulation of epithelial cell migration (GO:0010634)2.61281273
83muscle cell migration (GO:0014812)2.61276131
84peptidyl-proline hydroxylation (GO:0019511)2.60647460
85lung lobe morphogenesis (GO:0060463)2.58699494
86lung vasculature development (GO:0060426)2.57853098
87lymph vessel development (GO:0001945)2.57490672
88artery development (GO:0060840)2.56212733
89positive regulation of extracellular matrix organization (GO:1903055)2.56015658
90heparan sulfate proteoglycan metabolic process (GO:0030201)2.53630825
91negative regulation of stem cell proliferation (GO:2000647)2.53515351
92regulation of endothelial cell apoptotic process (GO:2000351)2.52782048
93endothelial cell proliferation (GO:0001935)2.52734398
94extracellular matrix organization (GO:0030198)2.52728450
95regulation of blood vessel endothelial cell migration (GO:0043535)2.52226977
96extracellular structure organization (GO:0043062)2.51868783
97positive regulation of collagen biosynthetic process (GO:0032967)2.51702339
98regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.51653347
99cell migration involved in heart development (GO:0060973)2.51476632
100regulation of collagen metabolic process (GO:0010712)2.51280671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.64157655
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.11011655
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.69658306
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.48950122
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.45349816
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.16392833
7SMAD_19615063_ChIP-ChIP_OVARY_Human2.98658110
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.79810730
9CLOCK_20551151_ChIP-Seq_293T_Human2.68295717
10TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.57138260
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.52910468
12SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.52289278
13SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.52289278
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.49980198
15GATA2_21666600_ChIP-Seq_HMVEC_Human2.47772983
16* ELK3_25401928_ChIP-Seq_HUVEC_Human2.45695317
17EGR1_19374776_ChIP-ChIP_THP-1_Human2.43045423
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.41281063
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.37616262
20BRD4_25478319_ChIP-Seq_HGPS_Human2.34428801
21UBF1/2_26484160_Chip-Seq_HMECs_Human2.17073104
22* TP53_22127205_ChIP-Seq_IMR90_Human2.14244833
23CJUN_26792858_Chip-Seq_BT549_Human2.11281906
24ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.07219762
25CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.02191020
26SALL4_18804426_ChIP-ChIP_XEN_Mouse1.99992914
27SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.96062030
28* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.96037062
29TP53_18474530_ChIP-ChIP_U2OS_Human1.91112048
30JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.83916619
31PPAR_26484153_Chip-Seq_NCI-H1993_Human1.82051277
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.78391705
33TP53_16413492_ChIP-PET_HCT116_Human1.71343166
34JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69397770
35CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.69207980
36* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.67386260
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66682700
38ATF3_27146783_Chip-Seq_COLON_Human1.66511182
39NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.59777843
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.59091359
41FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.58110664
42* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56847072
43ESR2_21235772_ChIP-Seq_MCF-7_Human1.55725111
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53460707
45SOX9_24532713_ChIP-Seq_HFSC_Mouse1.50985927
46EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.46763626
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42583566
48ZNF263_19887448_ChIP-Seq_K562_Human1.38602425
49NFIB_24661679_ChIP-Seq_LUNG_Mouse1.34719734
50NRF2_20460467_ChIP-Seq_MEFs_Mouse1.34614621
51NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.34614621
52ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.34551957
53KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.33151739
54KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.33151739
55KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.33151739
56HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33087714
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.31522180
58FOXO3_23340844_ChIP-Seq_DLD1_Human1.29694014
59* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.28390130
60KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24621865
61AR_21909140_ChIP-Seq_LNCAP_Human1.24517483
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24304898
63UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23369688
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20738881
65EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.20465338
66Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.19296179
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17044609
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16769514
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16562808
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.14477321
71TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12966524
72NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11069756
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08292163
74ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07813038
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.07260569
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.05882629
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.05793439
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.05793439
79ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05708190
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.05627228
81SOX2_20726797_ChIP-Seq_SW620_Human1.05061250
82ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04939128
83RACK7_27058665_Chip-Seq_MCF-7_Human1.03351215
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03150817
85TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03132604
86MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.02124980
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99413825
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98564372
89SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98361191
90KDM2B_26808549_Chip-Seq_K562_Human0.97666154
91TP53_23651856_ChIP-Seq_MEFs_Mouse0.96898631
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96738857
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.96108149
94SA1_22415368_ChIP-Seq_MEFs_Mouse0.95194984
95ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93805120
96ZFP281_27345836_Chip-Seq_ESCs_Mouse0.92631532
97ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.91885630
98TP53_20018659_ChIP-ChIP_R1E_Mouse0.91147176
99* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88395484
100TP63_23658742_ChIP-Seq_EP156T_Human0.86475294

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.91892778
2MP0004272_abnormal_basement_membrane5.06177850
3MP0010368_abnormal_lymphatic_system4.11659855
4MP0003705_abnormal_hypodermis_morpholog3.84972046
5MP0003566_abnormal_cell_adhesion3.62578378
6MP0003279_aneurysm3.29137631
7MP0005623_abnormal_meninges_morphology2.95553845
8MP0006054_spinal_hemorrhage2.75766232
9MP0005257_abnormal_intraocular_pressure2.75138418
10MP0005275_abnormal_skin_tensile2.58300710
11MP0003941_abnormal_skin_development2.41520983
12MP0003950_abnormal_plasma_membrane2.40222339
13MP0009053_abnormal_anal_canal2.26872996
14MP0003091_abnormal_cell_migration2.19465344
15MP0000767_abnormal_smooth_muscle2.15780612
16MP0001879_abnormal_lymphatic_vessel2.13010963
17MP0001958_emphysema2.09901740
18MP0010352_gastrointestinal_tract_polyps2.01690491
19MP0005023_abnormal_wound_healing1.95180756
20MP0002877_abnormal_melanocyte_morpholog1.89143452
21MP0002060_abnormal_skin_morphology1.83135474
22MP0003828_pulmonary_edema1.79848260
23MP0001542_abnormal_bone_strength1.77404483
24MP0009780_abnormal_chondrocyte_physiolo1.71109084
25MP0010030_abnormal_orbit_morphology1.63058887
26MP0000537_abnormal_urethra_morphology1.59500820
27MP0000858_altered_metastatic_potential1.58658789
28MP0009384_cardiac_valve_regurgitation1.56630687
29MP0009840_abnormal_foam_cell1.53123358
30MP0001915_intracranial_hemorrhage1.50406631
31MP0005503_abnormal_tendon_morphology1.46049986
32MP0002295_abnormal_pulmonary_circulatio1.45439887
33MP0005409_darkened_coat_color1.39495727
34MP0000733_abnormal_muscle_development1.36710279
35MP0000762_abnormal_tongue_morphology1.33244745
36MP0002896_abnormal_bone_mineralization1.32989834
37MP0005508_abnormal_skeleton_morphology1.25432990
38MP0005164_abnormal_response_to1.21469918
39MP0003191_abnormal_cellular_cholesterol1.20714538
40MP0009250_abnormal_appendicular_skeleto1.18872420
41MP0003300_gastrointestinal_ulcer1.17778541
42MP0001849_ear_inflammation1.13224793
43MP0005165_increased_susceptibility_to1.12965466
44MP0003453_abnormal_keratinocyte_physiol1.12828604
45MP0000013_abnormal_adipose_tissue1.12813237
46MP0000534_abnormal_ureter_morphology1.12328474
47MP0005595_abnormal_vascular_smooth1.11897413
48MP0003385_abnormal_body_wall1.10688866
49MP0001614_abnormal_blood_vessel1.10436497
50MP0005197_abnormal_uvea_morphology1.05985272
51MP0003448_altered_tumor_morphology1.03933372
52MP0002089_abnormal_postnatal_growth/wei1.02335630
53MP0001243_abnormal_dermal_layer1.01957325
54MP0001299_abnormal_eye_distance/1.00507561
55MP0002128_abnormal_blood_circulation0.99825327
56MP0005451_abnormal_body_composition0.96760838
57MP0002925_abnormal_cardiovascular_devel0.95882717
58MP0005367_renal/urinary_system_phenotyp0.95762093
59MP0000516_abnormal_urinary_system0.95762093
60MP0005501_abnormal_skin_physiology0.95071703
61MP0000467_abnormal_esophagus_morphology0.90842798
62MP0003755_abnormal_palate_morphology0.89211992
63MP0004858_abnormal_nervous_system0.88685781
64MP0000428_abnormal_craniofacial_morphol0.88297603
65MP0000751_myopathy0.88124645
66MP0003942_abnormal_urinary_system0.85939552
67MP0000343_altered_response_to0.83552110
68MP0003315_abnormal_perineum_morphology0.80411067
69MP0005390_skeleton_phenotype0.77616897
70MP0002254_reproductive_system_inflammat0.77381153
71MP0005193_abnormal_anterior_eye0.77340055
72MP0005076_abnormal_cell_differentiation0.76281317
73MP0000432_abnormal_head_morphology0.75079989
74MP0000249_abnormal_blood_vessel0.74824559
75MP0010771_integument_phenotype0.74197157
76MP0002998_abnormal_bone_remodeling0.74083524
77MP0001216_abnormal_epidermal_layer0.73416592
78MP0006138_congestive_heart_failure0.73185675
79MP0000750_abnormal_muscle_regeneration0.72851351
80MP0002086_abnormal_extraembryonic_tissu0.72661539
81MP0005360_urolithiasis0.72350322
82MP0005621_abnormal_cell_physiology0.71807646
83MP0003935_abnormal_craniofacial_develop0.71615358
84MP0002697_abnormal_eye_size0.71514346
85MP0002796_impaired_skin_barrier0.70944102
86MP0002168_other_aberrant_phenotype0.70702081
87MP0002113_abnormal_skeleton_development0.69920576
88MP0004233_abnormal_muscle_weight0.69769905
89MP0002282_abnormal_trachea_morphology0.68407653
90MP0000163_abnormal_cartilage_morphology0.67986798
91MP0004510_myositis0.65546333
92MP0002933_joint_inflammation0.65386747
93MP0002932_abnormal_joint_morphology0.65072205
94MP0002092_abnormal_eye_morphology0.64387138
95MP0000678_abnormal_parathyroid_gland0.62978936
96MP0000627_abnormal_mammary_gland0.62940169
97MP0000003_abnormal_adipose_tissue0.60680585
98MP0001348_abnormal_lacrimal_gland0.60376092
99MP0002177_abnormal_outer_ear0.57753474
100MP0004883_abnormal_blood_vessel0.57165442

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.38939232
2Protrusio acetabuli (HP:0003179)6.53532337
3Aortic dissection (HP:0002647)4.99027997
4Arterial tortuosity (HP:0005116)4.82977935
5Vascular tortuosity (HP:0004948)4.73339864
6Atrophic scars (HP:0001075)4.61036852
7Follicular hyperkeratosis (HP:0007502)4.06873834
8Aortic aneurysm (HP:0004942)3.93916738
9Spinal rigidity (HP:0003306)3.78658483
10Ankle contracture (HP:0006466)3.77268453
11Soft skin (HP:0000977)3.69517219
12Fragile skin (HP:0001030)3.65359142
13Abnormality of dentin (HP:0010299)3.37999363
14Genu recurvatum (HP:0002816)3.34806632
15Spondylolisthesis (HP:0003302)3.26740391
16Mitral valve prolapse (HP:0001634)3.25185430
17Bladder diverticulum (HP:0000015)3.18448938
18Blue sclerae (HP:0000592)3.13933244
19Wormian bones (HP:0002645)3.12910654
20Cervical subluxation (HP:0003308)2.94754381
21Peritonitis (HP:0002586)2.90862863
22Neonatal short-limb short stature (HP:0008921)2.87998378
23Cerebral aneurysm (HP:0004944)2.86437305
24Overgrowth (HP:0001548)2.75168646
25Type 1 muscle fiber predominance (HP:0003803)2.72527567
26Dilatation of the ascending aorta (HP:0005111)2.70354427
27Shallow orbits (HP:0000586)2.68621741
28Vertebral compression fractures (HP:0002953)2.61580347
29Joint laxity (HP:0001388)2.58290909
30Short nail (HP:0001799)2.49240590
31Abnormality of the acetabulum (HP:0003170)2.46570959
32Aortic regurgitation (HP:0001659)2.45706212
33Disproportionate tall stature (HP:0001519)2.44331261
34Achilles tendon contracture (HP:0001771)2.44218654
35Cardiovascular calcification (HP:0011915)2.43485620
36Slender build (HP:0001533)2.43463616
37Nonimmune hydrops fetalis (HP:0001790)2.42927808
38Hyperextensible skin (HP:0000974)2.41329072
39Elbow flexion contracture (HP:0002987)2.40133798
40Ulnar bowing (HP:0003031)2.39630248
41Ankyloglossia (HP:0010296)2.37320737
42Entropion (HP:0000621)2.34779732
43Abnormality of oral frenula (HP:0000190)2.34735352
44Mildly elevated creatine phosphokinase (HP:0008180)2.24322444
45Abnormality of the Achilles tendon (HP:0005109)2.23339213
46Spinal cord lesions (HP:0100561)2.21703432
47Syringomyelia (HP:0003396)2.21703432
48Ectopia lentis (HP:0001083)2.19836365
49Broad metatarsal (HP:0001783)2.19693617
50Aneurysm (HP:0002617)2.19450259
51Mitral regurgitation (HP:0001653)2.18793066
52Increased variability in muscle fiber diameter (HP:0003557)2.18023568
53Protruding ear (HP:0000411)2.17705202
54Tetraparesis (HP:0002273)2.17626917
55Generalized amyotrophy (HP:0003700)2.17312770
56Abnormal delivery (HP:0001787)2.14456966
57Mitral stenosis (HP:0001718)2.13610776
58Natal tooth (HP:0000695)2.11253908
59Abnormality of carpal bone ossification (HP:0006257)2.03861247
60Deep venous thrombosis (HP:0002625)2.03291811
61Abnormal ossification of hand bones (HP:0005921)2.00894208
62Wide anterior fontanel (HP:0000260)1.95867779
63Camptodactyly of toe (HP:0001836)1.95535379
64Biconcave vertebral bodies (HP:0004586)1.93849924
65Fragile nails (HP:0001808)1.91968099
66Osteolytic defects of the hand bones (HP:0009699)1.88899240
67Osteolytic defects of the phalanges of the hand (HP:0009771)1.88899240
68Joint stiffness (HP:0001387)1.88773686
69Abnormality of skeletal muscle fiber size (HP:0012084)1.86041406
70Long toe (HP:0010511)1.85523568
71Ovoid vertebral bodies (HP:0003300)1.82975246
72Squamous cell carcinoma (HP:0002860)1.82010438
73Knee flexion contracture (HP:0006380)1.80448355
74Bowed forearm bones (HP:0003956)1.79449121
75Bowing of the arm (HP:0006488)1.79449121
76Arachnodactyly (HP:0001166)1.78266130
77Milia (HP:0001056)1.77253076
78Vascular calcification (HP:0004934)1.76648513
79Osteopenia (HP:0000938)1.76647666
80Myocardial infarction (HP:0001658)1.76442045
81Aortic valve stenosis (HP:0001650)1.75788092
82Bowel diverticulosis (HP:0005222)1.75432068
83Distal upper limb amyotrophy (HP:0007149)1.75082997
84Upper limb amyotrophy (HP:0009129)1.75082997
85Thin skin (HP:0000963)1.74861568
86Broad face (HP:0000283)1.74588901
87Difficulty climbing stairs (HP:0003551)1.74061125
88Hypoventilation (HP:0002791)1.72254543
89Coxa vara (HP:0002812)1.71409699
90Cupped ribs (HP:0000887)1.70457349
91Wrist flexion contracture (HP:0001239)1.70233408
92Flexion contracture of toe (HP:0005830)1.69598492
93Joint contractures involving the joints of the feet (HP:0100492)1.69598492
94Inguinal hernia (HP:0000023)1.68900619
95Menorrhagia (HP:0000132)1.68607085
96Increased connective tissue (HP:0009025)1.65313948
97Distal lower limb amyotrophy (HP:0008944)1.65130411
98Femoral bowing (HP:0002980)1.64659012
99Reduced subcutaneous adipose tissue (HP:0003758)1.64280307
100Hypoplasia of the iris (HP:0007676)1.62302938

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.12835343
2EPHA23.97955868
3TIE13.84125238
4LATS23.34775611
5EPHB23.29499466
6PDGFRA2.90167401
7ERBB42.84330109
8BRD42.76262505
9TGFBR22.76105685
10MYLK2.53411327
11PTK22.46504568
12TTN2.40097436
13NTRK12.37480365
14PIM22.23540122
15RIPK12.08800955
16DDR22.02831092
17LATS11.99088177
18IRAK31.98624073
19MOS1.81444827
20PAK41.72518983
21MET1.67697480
22FLT31.67599075
23NEK91.61010666
24PAK21.58577007
25MAP3K31.54891240
26ARAF1.40942457
27SIK11.28361382
28STK381.23938811
29AKT31.22571271
30ERN11.22372355
31CDK91.14133034
32MAP2K31.08427513
33PDGFRB1.07054177
34KDR1.04822978
35MELK1.00758113
36EPHB10.99423775
37TAOK20.96188294
38CDK80.95785139
39TRIB30.93712152
40LIMK10.93011502
41ICK0.90769441
42MST1R0.90522664
43ROCK20.90094316
44DAPK30.89386052
45RPS6KA20.88760440
46PRKD20.87156971
47TESK10.83758218
48PRKG20.82762138
49SMG10.82554925
50ABL20.82052173
51MTOR0.79316634
52BRSK20.75527534
53MAP3K120.74258532
54ROCK10.73300349
55GRK70.72818053
56CDC42BPA0.70753965
57PIK3CG0.69116639
58TRPM70.67512704
59DYRK1B0.67444877
60EIF2AK30.67177850
61PRPF4B0.65942489
62FER0.65625959
63STK30.65011469
64MAP3K130.62998342
65NME20.61460195
66GSK3A0.60401974
67STK100.59047868
68TSSK60.58613603
69CDK60.58437982
70MAP3K50.57057887
71MAP3K90.55951655
72MAP3K80.53081056
73RPS6KL10.52126846
74RPS6KC10.52126846
75SCYL20.51099337
76KSR20.49054907
77STK38L0.48566670
78PTK2B0.48212501
79CLK10.47506353
80GRK50.46156937
81TESK20.43176840
82CDK70.41524967
83BRAF0.41180780
84ZAP700.39732250
85PKN20.38483322
86MAP3K140.37574616
87FGFR40.35820347
88CHUK0.33584633
89RPS6KA60.33532769
90KSR10.33439751
91MAP3K10.32900668
92ADRBK10.32895160
93STK240.32840490
94LMTK20.31589395
95FGFR10.30271534
96TGFBR10.29367109
97WNK10.28653685
98ILK0.28260046
99INSR0.27045566
100PTK60.26293296

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.40292198
2ECM-receptor interaction_Homo sapiens_hsa045123.68626583
3Bladder cancer_Homo sapiens_hsa052192.71009863
4Focal adhesion_Homo sapiens_hsa045102.70548844
5Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.43066170
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.26921896
7Proteoglycans in cancer_Homo sapiens_hsa052052.23079819
8Small cell lung cancer_Homo sapiens_hsa052222.18412026
9AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.14881880
10p53 signaling pathway_Homo sapiens_hsa041152.04839338
11Amoebiasis_Homo sapiens_hsa051461.99639791
12Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.89505873
13Other glycan degradation_Homo sapiens_hsa005111.83294902
14Adherens junction_Homo sapiens_hsa045201.82359394
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.78833420
16TGF-beta signaling pathway_Homo sapiens_hsa043501.73351080
17Chronic myeloid leukemia_Homo sapiens_hsa052201.64407053
18Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.62679809
19Complement and coagulation cascades_Homo sapiens_hsa046101.60046091
20Prion diseases_Homo sapiens_hsa050201.58819628
21MicroRNAs in cancer_Homo sapiens_hsa052061.58598981
22Hippo signaling pathway_Homo sapiens_hsa043901.57815227
23Regulation of actin cytoskeleton_Homo sapiens_hsa048101.54943673
24Protein digestion and absorption_Homo sapiens_hsa049741.46833107
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.41226791
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.38505308
27Malaria_Homo sapiens_hsa051441.35930920
28Thyroid cancer_Homo sapiens_hsa052161.27625195
29Dilated cardiomyopathy_Homo sapiens_hsa054141.26916002
30Basal cell carcinoma_Homo sapiens_hsa052171.25057935
31Pathways in cancer_Homo sapiens_hsa052001.21581778
32Shigellosis_Homo sapiens_hsa051311.18474677
33TNF signaling pathway_Homo sapiens_hsa046681.18381385
34Melanoma_Homo sapiens_hsa052181.13513897
35Renal cell carcinoma_Homo sapiens_hsa052111.05559771
36Central carbon metabolism in cancer_Homo sapiens_hsa052301.05235157
37Hedgehog signaling pathway_Homo sapiens_hsa043401.03287538
38Pancreatic cancer_Homo sapiens_hsa052121.02933698
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.02518524
40Prostate cancer_Homo sapiens_hsa052150.96419715
41N-Glycan biosynthesis_Homo sapiens_hsa005100.91205931
42Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.89332489
43Glioma_Homo sapiens_hsa052140.89101986
44* Apoptosis_Homo sapiens_hsa042100.88991326
45Axon guidance_Homo sapiens_hsa043600.87142952
46Rap1 signaling pathway_Homo sapiens_hsa040150.85794922
47Salmonella infection_Homo sapiens_hsa051320.84353845
48Sphingolipid metabolism_Homo sapiens_hsa006000.84268414
49Lysosome_Homo sapiens_hsa041420.83253568
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81090780
51Endometrial cancer_Homo sapiens_hsa052130.80237642
52Hepatitis B_Homo sapiens_hsa051610.78384888
53FoxO signaling pathway_Homo sapiens_hsa040680.78210429
54Vibrio cholerae infection_Homo sapiens_hsa051100.77808793
55Toxoplasmosis_Homo sapiens_hsa051450.75781428
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.74558183
57Thyroid hormone signaling pathway_Homo sapiens_hsa049190.72885588
58Galactose metabolism_Homo sapiens_hsa000520.72518458
59Pertussis_Homo sapiens_hsa051330.72417787
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71288403
61Endocytosis_Homo sapiens_hsa041440.71061462
62Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71049205
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.71021089
64ErbB signaling pathway_Homo sapiens_hsa040120.70925310
65Tight junction_Homo sapiens_hsa045300.69804975
66VEGF signaling pathway_Homo sapiens_hsa043700.67590314
67Estrogen signaling pathway_Homo sapiens_hsa049150.67466723
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67308549
69Notch signaling pathway_Homo sapiens_hsa043300.66204750
70Sulfur metabolism_Homo sapiens_hsa009200.65397052
71Melanogenesis_Homo sapiens_hsa049160.63273103
72Viral carcinogenesis_Homo sapiens_hsa052030.62980323
73HIF-1 signaling pathway_Homo sapiens_hsa040660.62323608
74Phospholipase D signaling pathway_Homo sapiens_hsa040720.61465286
75Wnt signaling pathway_Homo sapiens_hsa043100.60080919
76African trypanosomiasis_Homo sapiens_hsa051430.59546145
77Acute myeloid leukemia_Homo sapiens_hsa052210.56039410
78HTLV-I infection_Homo sapiens_hsa051660.55068347
79Hepatitis C_Homo sapiens_hsa051600.54487754
80* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.54128101
81Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53657318
82Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.53514888
83Prolactin signaling pathway_Homo sapiens_hsa049170.53384645
84Non-small cell lung cancer_Homo sapiens_hsa052230.52843126
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.51859566
86Platelet activation_Homo sapiens_hsa046110.50481331
87Gap junction_Homo sapiens_hsa045400.49842558
88GnRH signaling pathway_Homo sapiens_hsa049120.49577323
89Legionellosis_Homo sapiens_hsa051340.49483974
90Colorectal cancer_Homo sapiens_hsa052100.48882520
91MAPK signaling pathway_Homo sapiens_hsa040100.48289484
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.45896320
93Ras signaling pathway_Homo sapiens_hsa040140.42178450
94* Influenza A_Homo sapiens_hsa051640.41996253
95Longevity regulating pathway - mammal_Homo sapiens_hsa042110.40061344
96Dorso-ventral axis formation_Homo sapiens_hsa043200.39767942
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.39633546
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37195210
99Hematopoietic cell lineage_Homo sapiens_hsa046400.37120361
100NF-kappa B signaling pathway_Homo sapiens_hsa040640.34642192

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