TNFRSF10A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleoside salvage (GO:0043097)6.53930035
2pyrimidine-containing compound salvage (GO:0008655)6.53930035
3pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)6.04392213
4UMP metabolic process (GO:0046049)6.04392213
5pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)6.04392213
6UMP biosynthetic process (GO:0006222)6.04392213
7nucleotide salvage (GO:0043173)5.87788088
8nucleoside salvage (GO:0043174)5.83790120
9pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)4.96168850
10pyrimidine nucleoside monophosphate metabolic process (GO:0009129)4.52156148
11diterpenoid biosynthetic process (GO:0016102)4.21978970
12keratinocyte development (GO:0003334)4.14178722
13pentose-phosphate shunt (GO:0006098)4.08284058
14positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96245910
15neutrophil activation involved in immune response (GO:0002283)3.84526533
16hemidesmosome assembly (GO:0031581)3.83191107
17positive regulation of epidermal cell differentiation (GO:0045606)3.79011120
18negative T cell selection (GO:0043383)3.78749824
19negative thymic T cell selection (GO:0045060)3.77997324
20positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.67128850
21pentose metabolic process (GO:0019321)3.60202777
22NADPH regeneration (GO:0006740)3.55744945
23positive regulation of gamma-delta T cell activation (GO:0046645)3.46187896
24T cell selection (GO:0045058)3.21881854
25thymic T cell selection (GO:0045061)3.19038333
26positive regulation of alpha-beta T cell proliferation (GO:0046641)3.10979135
27glucose catabolic process (GO:0006007)3.09182804
28antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.06429692
29regulation of regulatory T cell differentiation (GO:0045589)3.04355461
30establishment of skin barrier (GO:0061436)3.01202519
31tolerance induction (GO:0002507)2.99306776
32negative regulation of T cell mediated immunity (GO:0002710)2.97621506
33negative regulation of keratinocyte proliferation (GO:0010839)2.96448139
34positive regulation of epidermis development (GO:0045684)2.95329987
35regulation of dendritic cell antigen processing and presentation (GO:0002604)2.91130217
36regulation of T cell tolerance induction (GO:0002664)2.88187886
37terpenoid biosynthetic process (GO:0016114)2.86575010
38regulation of B cell receptor signaling pathway (GO:0050855)2.85953679
39purine nucleotide salvage (GO:0032261)2.85420502
40antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.82543725
41regulation of activation of Janus kinase activity (GO:0010533)2.80508639
42negative regulation of interleukin-8 production (GO:0032717)2.79699426
43neutrophil mediated immunity (GO:0002446)2.79038086
44cellular metabolic compound salvage (GO:0043094)2.75897439
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.73317919
46type I interferon signaling pathway (GO:0060337)2.71901543
47cellular response to type I interferon (GO:0071357)2.71901543
48regulation of water loss via skin (GO:0033561)2.71496902
49negative regulation of interleukin-12 production (GO:0032695)2.69734680
50response to type I interferon (GO:0034340)2.69676657
51regulation of hypersensitivity (GO:0002883)2.69603501
52negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.68355865
53T cell migration (GO:0072678)2.67920564
54interleukin-6-mediated signaling pathway (GO:0070102)2.67734986
55positive regulation of T cell mediated cytotoxicity (GO:0001916)2.67316141
56regulation of alpha-beta T cell proliferation (GO:0046640)2.67024147
57regulation of translational termination (GO:0006449)2.66746558
58CTP biosynthetic process (GO:0006241)2.66196097
59CTP metabolic process (GO:0046036)2.66196097
60pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.63561234
61neutrophil activation (GO:0042119)2.63506518
62regulation of interleukin-2 biosynthetic process (GO:0045076)2.63301579
63granulocyte activation (GO:0036230)2.61940359
64antigen processing and presentation of endogenous antigen (GO:0019883)2.61333223
65necroptotic process (GO:0070266)2.61011489
66hepatocyte apoptotic process (GO:0097284)2.57399773
67pyrimidine ribonucleoside biosynthetic process (GO:0046132)2.51299324
68positive regulation of tolerance induction (GO:0002645)2.50456841
69regulation of vitamin D biosynthetic process (GO:0060556)2.49965745
70dendritic cell chemotaxis (GO:0002407)2.48258586
71regulation of T cell mediated cytotoxicity (GO:0001914)2.47687502
72positive regulation of keratinocyte differentiation (GO:0045618)2.46857581
73cellular extravasation (GO:0045123)2.46602019
74positive thymic T cell selection (GO:0045059)2.46067724
75leukocyte degranulation (GO:0043299)2.45406607
76lymphocyte migration (GO:0072676)2.44159827
77positive regulation of interleukin-2 production (GO:0032743)2.42957673
78nuclear pore complex assembly (GO:0051292)2.42445558
79leukocyte aggregation (GO:0070486)2.42085435
80regulation of T cell receptor signaling pathway (GO:0050856)2.41952232
81AMP metabolic process (GO:0046033)2.41551953
82negative regulation of cell killing (GO:0031342)2.41279225
83negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.41279225
84positive regulation of humoral immune response (GO:0002922)2.41060587
85regulation of tolerance induction (GO:0002643)2.40397568
86regulation of gamma-delta T cell activation (GO:0046643)2.40149168
87regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.39465010
88NIK/NF-kappaB signaling (GO:0038061)2.38217425
89pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.37588157
90lymphocyte chemotaxis (GO:0048247)2.37354368
91regulation of interferon-alpha production (GO:0032647)2.35625096
92regulation of gamma-delta T cell differentiation (GO:0045586)2.34660592
93germinal center formation (GO:0002467)2.33822721
94positive regulation of T cell chemotaxis (GO:0010820)2.32274186
95regulation of T cell chemotaxis (GO:0010819)2.32274186
96positive regulation of antigen processing and presentation (GO:0002579)2.30710031
97positive regulation of interferon-alpha production (GO:0032727)2.29400301
98negative regulation of cytokine production involved in immune response (GO:0002719)2.29074431
99regulation of chronic inflammatory response (GO:0002676)2.28130199
100JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.28049160

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.70869294
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.09542625
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.85109415
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.07829298
5E2F7_22180533_ChIP-Seq_HELA_Human2.68029752
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.59903469
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.56843990
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.34203611
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.31109291
10IRF8_21731497_ChIP-ChIP_J774_Mouse2.28779142
11MYC_22102868_ChIP-Seq_BL_Human2.22553045
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.18528587
13RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.15907673
14SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.15904301
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.08393633
16TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.07895294
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05339637
18STAT4_19710469_ChIP-ChIP_TH1__Mouse2.05005148
19* MYB_26560356_Chip-Seq_TH2_Human2.03083364
20MYB_26560356_Chip-Seq_TH1_Human1.98430047
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95445890
22SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95445890
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95362520
24MAF_26560356_Chip-Seq_TH1_Human1.94938741
25* RUNX_20019798_ChIP-Seq_JUKART_Human1.90945993
26NOTCH1_21737748_ChIP-Seq_TLL_Human1.90569116
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.90547671
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88472303
29IRF8_27001747_Chip-Seq_BMDM_Mouse1.79349309
30SPI1_23547873_ChIP-Seq_NB4_Human1.77274197
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74727863
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71566549
33EGR1_19374776_ChIP-ChIP_THP-1_Human1.71212926
34BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66909296
35VDR_21846776_ChIP-Seq_THP-1_Human1.61756544
36HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.55646714
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.55475966
38MYC_18555785_ChIP-Seq_MESCs_Mouse1.52543628
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.51165195
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.48551583
41* UTX_26944678_Chip-Seq_JUKART_Human1.47728483
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46686657
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.46575203
44VDR_24763502_ChIP-Seq_THP-1_Human1.46307418
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.44322735
46KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42402027
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.39739314
48MAF_26560356_Chip-Seq_TH2_Human1.37874049
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37543402
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.36812891
51* GATA3_26560356_Chip-Seq_TH2_Human1.34845102
52STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33589089
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.32847806
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.32710849
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31752145
56CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31413065
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.26613549
58ATF3_27146783_Chip-Seq_COLON_Human1.25259227
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.23131794
60EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.21662238
61FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.17935010
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16682284
63TFEB_21752829_ChIP-Seq_HELA_Human1.16558775
64Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16541259
65GATA3_27048872_Chip-Seq_THYMUS_Human1.15568090
66TCF7_22412390_ChIP-Seq_EML_Mouse1.15476375
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.12545130
68ELK1_19687146_ChIP-ChIP_HELA_Human1.12241107
69GABP_17652178_ChIP-ChIP_JURKAT_Human1.12063595
70ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10981394
71STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10809260
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.10032203
73DCP1A_22483619_ChIP-Seq_HELA_Human1.06910488
74* VDR_23849224_ChIP-Seq_CD4+_Human1.06683563
75MYC_18358816_ChIP-ChIP_MESCs_Mouse1.06624009
76SPI1_23127762_ChIP-Seq_K562_Human1.05608563
77NCOR1_26117541_ChIP-Seq_K562_Human1.05095281
78JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04613150
79FOXP3_21729870_ChIP-Seq_TREG_Human1.04501097
80* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04228924
81PU_27001747_Chip-Seq_BMDM_Mouse1.04220506
82P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03685458
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02237271
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.01788275
85GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00412141
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.00143615
87SCL_19346495_ChIP-Seq_HPC-7_Human0.99836837
88* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99055864
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.98963914
90TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.96995963
91NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95566631
92ELF5_23300383_ChIP-Seq_T47D_Human0.95096660
93ELK1_22589737_ChIP-Seq_MCF10A_Human0.94755198
94PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94368188
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.94011223
96GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92489887
97MYC_19030024_ChIP-ChIP_MESCs_Mouse0.91286747
98CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90876930
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89672127
100FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.88782315

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001873_stomach_inflammation2.80927922
2MP0003763_abnormal_thymus_physiology2.80036438
3MP0003436_decreased_susceptibility_to2.65140883
4MP0001835_abnormal_antigen_presentation2.51418127
5MP0005000_abnormal_immune_tolerance2.48072319
6MP0003724_increased_susceptibility_to2.47320813
7MP0010234_abnormal_vibrissa_follicle2.46576430
8MP0002148_abnormal_hypersensitivity_rea2.41415354
9MP0009785_altered_susceptibility_to2.30995259
10MP0003806_abnormal_nucleotide_metabolis2.22993076
11MP0005451_abnormal_body_composition2.20146195
12MP0004947_skin_inflammation2.19523020
13MP0001800_abnormal_humoral_immune2.18523892
14MP0002452_abnormal_antigen_presenting2.10644802
15MP0005387_immune_system_phenotype2.05322767
16MP0001790_abnormal_immune_system2.05322767
17MP0002723_abnormal_immune_serum2.03442693
18MP0006082_CNS_inflammation2.02614255
19MP0005671_abnormal_response_to2.00509994
20MP0003300_gastrointestinal_ulcer2.00439835
21MP0005025_abnormal_response_to1.92142448
22MP0002420_abnormal_adaptive_immunity1.91384865
23MP0001819_abnormal_immune_cell1.90912792
24MP0010155_abnormal_intestine_physiology1.89659018
25MP0002419_abnormal_innate_immunity1.88075667
26MP0005310_abnormal_salivary_gland1.85224617
27MP0009333_abnormal_splenocyte_physiolog1.83665657
28MP0003453_abnormal_keratinocyte_physiol1.81757199
29MP0000685_abnormal_immune_system1.81397164
30MP0000858_altered_metastatic_potential1.76791668
31MP0003303_peritoneal_inflammation1.71800073
32MP0010678_abnormal_skin_adnexa1.71704551
33MP0003191_abnormal_cellular_cholesterol1.71183974
34MP0002877_abnormal_melanocyte_morpholog1.66669609
35MP0001853_heart_inflammation1.63911627
36MP0002006_tumorigenesis1.63197701
37MP0001845_abnormal_inflammatory_respons1.62899213
38MP0002398_abnormal_bone_marrow1.58807204
39MP0002405_respiratory_system_inflammati1.55723034
40MP0000716_abnormal_immune_system1.55420694
41MP0002166_altered_tumor_susceptibility1.50341450
42MP0002796_impaired_skin_barrier1.47630017
43MP0001216_abnormal_epidermal_layer1.43743198
44MP0002722_abnormal_immune_system1.39712676
45MP0000703_abnormal_thymus_morphology1.38760490
46MP0000383_abnormal_hair_follicle1.38535866
47MP0003566_abnormal_cell_adhesion1.36309730
48MP0008057_abnormal_DNA_replication1.36117775
49MP0009840_abnormal_foam_cell1.36013507
50MP0000689_abnormal_spleen_morphology1.35422356
51MP0005464_abnormal_platelet_physiology1.33295623
52MP0002429_abnormal_blood_cell1.33021103
53MP0001533_abnormal_skeleton_physiology1.31560982
54MP0002396_abnormal_hematopoietic_system1.31087727
55MP0000465_gastrointestinal_hemorrhage1.28463016
56MP0000579_abnormal_nail_morphology1.25122452
57MP0005360_urolithiasis1.24172808
58MP0004381_abnormal_hair_follicle1.22370714
59MP0009764_decreased_sensitivity_to1.21561975
60MP0003448_altered_tumor_morphology1.17995756
61MP0003091_abnormal_cell_migration1.17509991
62MP0001348_abnormal_lacrimal_gland1.16563379
63MP0008469_abnormal_protein_level1.15702935
64MP0003950_abnormal_plasma_membrane1.11523769
65MP0002933_joint_inflammation1.10285827
66MP0000490_abnormal_crypts_of1.09830183
67MP0008007_abnormal_cellular_replicative1.09161045
68MP0005023_abnormal_wound_healing1.09104326
69MP0002138_abnormal_hepatobiliary_system1.07124106
70MP0004264_abnormal_extraembryonic_tissu1.02597836
71MP0004808_abnormal_hematopoietic_stem1.00785915
72MP0003866_abnormal_defecation0.97440109
73MP0001851_eye_inflammation0.96606021
74MP0002019_abnormal_tumor_incidence0.96095393
75MP0003828_pulmonary_edema0.95210920
76MP0005501_abnormal_skin_physiology0.94448829
77MP0002060_abnormal_skin_morphology0.94421934
78MP0010352_gastrointestinal_tract_polyps0.93371512
79MP0003786_premature_aging0.93219928
80MP0002098_abnormal_vibrissa_morphology0.93154856
81MP0002009_preneoplasia0.92463152
82MP0005165_increased_susceptibility_to0.91678141
83MP0002998_abnormal_bone_remodeling0.89825719
84MP0005164_abnormal_response_to0.88476590
85MP0003656_abnormal_erythrocyte_physiolo0.86689683
86MP0009763_increased_sensitivity_to0.85274730
87MP0008875_abnormal_xenobiotic_pharmacok0.84296327
88MP0003693_abnormal_embryo_hatching0.83261044
89MP0001191_abnormal_skin_condition0.82822831
90MP0003941_abnormal_skin_development0.82127229
91MP0005167_abnormal_blood-brain_barrier0.82062194
92MP0004957_abnormal_blastocyst_morpholog0.80979348
93MP0000467_abnormal_esophagus_morphology0.80961451
94MP0001545_abnormal_hematopoietic_system0.78220375
95MP0005397_hematopoietic_system_phenotyp0.78220375
96MP0003075_altered_response_to0.77815982
97MP0001663_abnormal_digestive_system0.76507722
98MP0009931_abnormal_skin_appearance0.76461845
99MP0002136_abnormal_kidney_physiology0.76327023
100MP0004185_abnormal_adipocyte_glucose0.76292118

Predicted human phenotypes

RankGene SetZ-score
1Milia (HP:0001056)4.60547561
2Pustule (HP:0200039)4.18757779
3Onycholysis (HP:0001806)4.06876840
4Thick nail (HP:0001805)3.95455535
5Autoimmune hemolytic anemia (HP:0001890)3.92771614
6Plantar hyperkeratosis (HP:0007556)3.72727370
7Elevated erythrocyte sedimentation rate (HP:0003565)3.62281244
8Hypoplasia of the pons (HP:0012110)3.55322049
9Autoimmune thrombocytopenia (HP:0001973)3.47923882
10Abnormality of the pons (HP:0007361)3.39918400
11Myositis (HP:0100614)3.36500096
12Achilles tendon contracture (HP:0001771)3.33998944
13T lymphocytopenia (HP:0005403)3.22978799
14Abnormality of T cell number (HP:0011839)3.16384540
15Abnormality of the Achilles tendon (HP:0005109)3.06475049
16Fragile nails (HP:0001808)3.01057403
17Optic neuritis (HP:0100653)2.99097913
18Retrobulbar optic neuritis (HP:0100654)2.99097913
19Difficulty running (HP:0009046)2.97244549
20Orchitis (HP:0100796)2.97178587
21Ridged nail (HP:0001807)2.94982238
22Mediastinal lymphadenopathy (HP:0100721)2.93668972
23Stomatitis (HP:0010280)2.91936503
24Eczematoid dermatitis (HP:0000976)2.91749551
25Abnormality of macrophages (HP:0004311)2.89814826
26Abnormality of nail color (HP:0100643)2.88808087
27Nail dystrophy (HP:0008404)2.88413222
28Palmoplantar hyperkeratosis (HP:0000972)2.86316801
29Parakeratosis (HP:0001036)2.85761776
30Recurrent bacterial skin infections (HP:0005406)2.85072215
31Abnormality of T cells (HP:0002843)2.68646775
32Alopecia of scalp (HP:0002293)2.62187830
33Palmar hyperkeratosis (HP:0010765)2.60747669
34Abnormality of liposaccharide metabolism (HP:0010968)2.60210906
35Abnormality of glycosphingolipid metabolism (HP:0004343)2.60210906
36Abnormality of glycolipid metabolism (HP:0010969)2.60210906
37Spondylolisthesis (HP:0003302)2.59308905
38Abnormal blistering of the skin (HP:0008066)2.57316257
39Recurrent abscess formation (HP:0002722)2.55785983
40Pili torti (HP:0003777)2.53997422
41Recurrent viral infections (HP:0004429)2.51066083
42Abnormality of T cell physiology (HP:0011840)2.47165523
43Abnormal delayed hypersensitivity skin test (HP:0002963)2.46491459
44Keratoconjunctivitis sicca (HP:0001097)2.42844796
45Increased serum ferritin (HP:0003281)2.40522897
46Aplasia cutis congenita (HP:0001057)2.31806166
47Sparse eyelashes (HP:0000653)2.27663213
48Selective tooth agenesis (HP:0001592)2.27229253
49Squamous cell carcinoma (HP:0002860)2.26916818
50Vasculitis (HP:0002633)2.25386992
51Right ventricular cardiomyopathy (HP:0011663)2.22801578
52Keratoconjunctivitis (HP:0001096)2.22716970
53Recurrent fungal infections (HP:0002841)2.22086666
54Granulocytopenia (HP:0001913)2.19595535
55Abnormality of oral frenula (HP:0000190)2.15084824
56Hip dysplasia (HP:0001385)2.13765067
57Interstitial pulmonary disease (HP:0006530)2.13264974
58IgM deficiency (HP:0002850)2.07766775
59Abnormal hair laboratory examination (HP:0003328)2.07279358
60IgG deficiency (HP:0004315)2.06119148
61Pulmonary infiltrates (HP:0002113)2.05387451
62Inflammation of the large intestine (HP:0002037)2.05346860
63Vacuolated lymphocytes (HP:0001922)2.03554794
64Meningitis (HP:0001287)2.03429281
65Gastrointestinal inflammation (HP:0004386)2.02714722
66Eosinophilia (HP:0001880)2.01663947
67Gangrene (HP:0100758)2.01318392
68Oral leukoplakia (HP:0002745)2.01303739
69Erythema (HP:0010783)2.00220952
70Abnormality of the fingertips (HP:0001211)1.99144849
71Subacute progressive viral hepatitis (HP:0006572)1.97596180
72Colitis (HP:0002583)1.97236738
73Thrombocytosis (HP:0001894)1.94907286
74Ankyloglossia (HP:0010296)1.92843233
75Papilloma (HP:0012740)1.92769864
76Verrucae (HP:0200043)1.92769864
77Ectropion (HP:0000656)1.90295993
78Abnormality of the periventricular white matter (HP:0002518)1.89463985
79Hematochezia (HP:0002573)1.88949240
80Anorexia (HP:0002039)1.88266840
81Encephalitis (HP:0002383)1.88197567
82Cheilitis (HP:0100825)1.88159187
83Skin ulcer (HP:0200042)1.87426064
84IgA deficiency (HP:0002720)1.87400071
85Atrophic scars (HP:0001075)1.87052846
86Recurrent bronchitis (HP:0002837)1.84773253
87Abnormality of B cell number (HP:0010975)1.82912869
88Dry hair (HP:0011359)1.81798932
89Progressive external ophthalmoplegia (HP:0000590)1.81448306
90Leukocytosis (HP:0001974)1.78888485
91Abnormality of iron homeostasis (HP:0011031)1.78020796
92Arterial thrombosis (HP:0004420)1.77641322
93Recurrent skin infections (HP:0001581)1.77322746
94Micronodular cirrhosis (HP:0001413)1.74653551
95Amniotic constriction ring (HP:0009775)1.74108902
96Abnormality of placental membranes (HP:0011409)1.74108902
97Obstructive lung disease (HP:0006536)1.72916872
98Chronic obstructive pulmonary disease (HP:0006510)1.72916872
99Fasciculations (HP:0002380)1.72903473
100Abnormality of cells of the lymphoid lineage (HP:0012140)1.72412528

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA23.98401729
2MST1R3.93566984
3MAP4K13.85214495
4IRAK33.05152691
5MST43.01903870
6TXK2.42571878
7NME22.38810104
8CDK122.32886075
9MAP3K142.30832930
10PIM22.04453937
11STK101.89397918
12SCYL21.72874095
13NLK1.58525876
14CSF1R1.58316514
15IKBKB1.57463786
16JAK31.56866353
17IRAK41.47643483
18TBK11.45705788
19LIMK11.43879102
20MAP3K131.42525719
21ERN11.34122139
22IKBKE1.33884273
23BTK1.33419582
24PRPF4B1.31292476
25MET1.30015984
26TESK21.28880913
27BMPR21.28538648
28RIPK41.26962352
29ITK1.24996270
30EIF2AK31.24009124
31TAOK31.22414904
32ZAP701.21510921
33CSK1.21201150
34TYK21.18801247
35SMG11.17130058
36BLK1.16664107
37TESK11.16124630
38LCK1.13992568
39TEC1.13016851
40SIK31.08910652
41ARAF1.05701887
42MAP3K31.03965833
43GRK61.03172341
44TSSK61.01864420
45TRPM71.00496865
46ERBB40.97258435
47JAK10.94523406
48TGFBR20.90617450
49SIK10.88596703
50SYK0.88307544
51MAP2K30.83583900
52LYN0.80683675
53HCK0.79282616
54TAOK20.78513035
55PIM10.77260405
56MAPKAPK30.76817409
57TGFBR10.76027489
58EPHB10.74540154
59BRSK20.72857617
60CHUK0.72581190
61PAK40.72560825
62MAP3K10.71019424
63TTN0.70068075
64GRK70.69937734
65BRD40.68190335
66LRRK20.66336212
67RPS6KB20.65088749
68MELK0.64401984
69MAPKAPK20.61613369
70FGR0.60816868
71MAP3K20.59580857
72MARK30.57883596
73CLK10.56680982
74MAP3K80.56640428
75CDK40.56434324
76MAPK110.55345016
77MOS0.55281454
78PASK0.54955214
79PBK0.53966661
80PRKCQ0.52664318
81EEF2K0.51396917
82RIPK10.48096793
83BMX0.48054177
84CDC42BPA0.47776474
85CDK60.46338337
86EIF2AK10.45541254
87PIK3CG0.45266631
88IRAK10.44820382
89CAMKK20.44694038
90PDK10.44467099
91EGFR0.43537914
92FES0.40801366
93IGF1R0.39596114
94RAF10.37789053
95ACVR1B0.37672874
96STK240.36665227
97MAP3K90.36655987
98KDR0.34327954
99MAP3K120.33970322
100MATK0.33495890

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041222.79838143
2Primary immunodeficiency_Homo sapiens_hsa053402.57463396
3Hematopoietic cell lineage_Homo sapiens_hsa046402.47625408
4NF-kappa B signaling pathway_Homo sapiens_hsa040642.35150988
5Allograft rejection_Homo sapiens_hsa053302.15912122
6Pentose phosphate pathway_Homo sapiens_hsa000302.05187674
7RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.01682157
8NOD-like receptor signaling pathway_Homo sapiens_hsa046212.01057041
9Autoimmune thyroid disease_Homo sapiens_hsa053202.00496762
10* Measles_Homo sapiens_hsa051621.98140914
11Graft-versus-host disease_Homo sapiens_hsa053321.97883484
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.96498169
13T cell receptor signaling pathway_Homo sapiens_hsa046601.93221521
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92428971
15Legionellosis_Homo sapiens_hsa051341.91713316
16Drug metabolism - other enzymes_Homo sapiens_hsa009831.87491947
17Osteoclast differentiation_Homo sapiens_hsa043801.81194446
18Leishmaniasis_Homo sapiens_hsa051401.78486417
19Intestinal immune network for IgA production_Homo sapiens_hsa046721.76682276
20Antigen processing and presentation_Homo sapiens_hsa046121.74751105
21* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71032199
22TNF signaling pathway_Homo sapiens_hsa046681.70945314
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.70564647
24Ribosome_Homo sapiens_hsa030101.67764436
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.64131268
26B cell receptor signaling pathway_Homo sapiens_hsa046621.63792455
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.56958040
28Malaria_Homo sapiens_hsa051441.54410995
29* Influenza A_Homo sapiens_hsa051641.50656510
30Herpes simplex infection_Homo sapiens_hsa051681.49910092
31Toxoplasmosis_Homo sapiens_hsa051451.43500968
32Pyrimidine metabolism_Homo sapiens_hsa002401.39589554
33* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.39386735
34* Apoptosis_Homo sapiens_hsa042101.38947155
35Other glycan degradation_Homo sapiens_hsa005111.36176826
36Acute myeloid leukemia_Homo sapiens_hsa052211.35241295
37Type I diabetes mellitus_Homo sapiens_hsa049401.31599370
38Thyroid cancer_Homo sapiens_hsa052161.24200259
39Hepatitis C_Homo sapiens_hsa051601.24141997
40Asthma_Homo sapiens_hsa053101.21633971
41Tuberculosis_Homo sapiens_hsa051521.19641211
42Viral myocarditis_Homo sapiens_hsa054161.18651401
43Hepatitis B_Homo sapiens_hsa051611.14920707
44Rheumatoid arthritis_Homo sapiens_hsa053231.14272842
45p53 signaling pathway_Homo sapiens_hsa041151.13730019
46Shigellosis_Homo sapiens_hsa051311.11010005
47Staphylococcus aureus infection_Homo sapiens_hsa051501.09678440
48Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.07643879
49Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.07084208
50Small cell lung cancer_Homo sapiens_hsa052221.01545931
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00872849
52Proteasome_Homo sapiens_hsa030500.99829227
53Epstein-Barr virus infection_Homo sapiens_hsa051690.99271330
54Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95650213
55Viral carcinogenesis_Homo sapiens_hsa052030.92111581
56Bladder cancer_Homo sapiens_hsa052190.86997370
57Pertussis_Homo sapiens_hsa051330.83622207
58Pancreatic cancer_Homo sapiens_hsa052120.82739736
59Chronic myeloid leukemia_Homo sapiens_hsa052200.82268596
60African trypanosomiasis_Homo sapiens_hsa051430.81563184
61DNA replication_Homo sapiens_hsa030300.80247111
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.76092642
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75852691
64HTLV-I infection_Homo sapiens_hsa051660.73790709
65Sulfur metabolism_Homo sapiens_hsa009200.73120213
66Chemokine signaling pathway_Homo sapiens_hsa040620.72775884
67Salmonella infection_Homo sapiens_hsa051320.72129054
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69447519
69Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.67549279
70Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66917579
71RNA polymerase_Homo sapiens_hsa030200.64173140
72Lysosome_Homo sapiens_hsa041420.63791962
73Non-homologous end-joining_Homo sapiens_hsa034500.63567071
74VEGF signaling pathway_Homo sapiens_hsa043700.58932819
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58893225
76SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57840804
77HIF-1 signaling pathway_Homo sapiens_hsa040660.57377222
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56463550
79Systemic lupus erythematosus_Homo sapiens_hsa053220.54863546
80N-Glycan biosynthesis_Homo sapiens_hsa005100.53523391
81Non-small cell lung cancer_Homo sapiens_hsa052230.52118361
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52044161
83FoxO signaling pathway_Homo sapiens_hsa040680.48182182
84RNA degradation_Homo sapiens_hsa030180.47878477
85Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46735158
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45695858
87Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.44611092
88Proteoglycans in cancer_Homo sapiens_hsa052050.44131653
89Prostate cancer_Homo sapiens_hsa052150.43043423
90Phagosome_Homo sapiens_hsa041450.39573771
91Renal cell carcinoma_Homo sapiens_hsa052110.39086642
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.38186167
93Sphingolipid metabolism_Homo sapiens_hsa006000.37713705
94Amoebiasis_Homo sapiens_hsa051460.36995981
95RNA transport_Homo sapiens_hsa030130.31333034
96MicroRNAs in cancer_Homo sapiens_hsa052060.31293660
97Prolactin signaling pathway_Homo sapiens_hsa049170.29262120
98Insulin resistance_Homo sapiens_hsa049310.27392301
99Glycerolipid metabolism_Homo sapiens_hsa005610.27387158
100Platelet activation_Homo sapiens_hsa046110.25159063

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