TMTC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the transmembrane and tetratricopeptide repeat-containing protein family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)6.50643611
2Golgi transport vesicle coating (GO:0048200)6.50643611
3DNA double-strand break processing (GO:0000729)4.59860992
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.37353657
5chromatin remodeling at centromere (GO:0031055)4.32283382
6CENP-A containing nucleosome assembly (GO:0034080)4.26562367
7COPII vesicle coating (GO:0048208)4.22299966
8nuclear pore complex assembly (GO:0051292)4.21704994
9nuclear pore organization (GO:0006999)4.08134812
10histone exchange (GO:0043486)3.95160216
11paraxial mesoderm development (GO:0048339)3.68654223
12cellular response to vitamin D (GO:0071305)3.64230717
13regulation of centriole replication (GO:0046599)3.64131146
14protein retention in ER lumen (GO:0006621)3.62696736
15positive regulation of SMAD protein import into nucleus (GO:0060391)3.59251590
16regulation of mesoderm development (GO:2000380)3.57515481
17chondrocyte proliferation (GO:0035988)3.56531827
18type B pancreatic cell development (GO:0003323)3.56463523
19mitotic sister chromatid cohesion (GO:0007064)3.50956205
20collagen fibril organization (GO:0030199)3.50689242
21positive regulation of hormone biosynthetic process (GO:0046886)3.48918037
22proteasome assembly (GO:0043248)3.44146888
23negative regulation of DNA-dependent DNA replication (GO:2000104)3.41089014
24retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.40142721
25replication fork processing (GO:0031297)3.37202192
26activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.37021287
27polarized epithelial cell differentiation (GO:0030859)3.35317649
28regulation of SMAD protein import into nucleus (GO:0060390)3.33573814
29hippo signaling (GO:0035329)3.32811789
30glandular epithelial cell development (GO:0002068)3.30817849
31DNA replication-dependent nucleosome assembly (GO:0006335)3.25886787
32DNA replication-dependent nucleosome organization (GO:0034723)3.25886787
33positive regulation of nuclease activity (GO:0032075)3.24879901
34intestinal epithelial cell development (GO:0060576)3.21061721
35regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.20802135
36DNA replication-independent nucleosome organization (GO:0034724)3.18035263
37DNA replication-independent nucleosome assembly (GO:0006336)3.18035263
38keratinocyte development (GO:0003334)3.17599153
39exocrine pancreas development (GO:0031017)3.17486936
40sequestering of metal ion (GO:0051238)3.16086180
41regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.15903261
42regulation of mitotic spindle checkpoint (GO:1903504)3.15332980
43regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.15332980
44columnar/cuboidal epithelial cell development (GO:0002066)3.15133494
45cellular response to vitamin (GO:0071295)3.12870496
46vesicle coating (GO:0006901)3.10583921
47metaphase plate congression (GO:0051310)3.09262962
48mitotic metaphase plate congression (GO:0007080)3.08429663
49pore complex assembly (GO:0046931)3.07627212
50regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.06276329
51synapsis (GO:0007129)3.04352666
52regulation of DNA endoreduplication (GO:0032875)3.03417641
53response to X-ray (GO:0010165)3.02826913
54RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.02174739
55regulation of nuclease activity (GO:0032069)3.01936075
56somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99564307
57somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99564307
58isotype switching (GO:0045190)2.99564307
59DNA replication checkpoint (GO:0000076)2.99184562
60cullin deneddylation (GO:0010388)2.98826488
61female gonad development (GO:0008585)2.98606915
62endodermal cell differentiation (GO:0035987)2.95715520
63endoplasmic reticulum unfolded protein response (GO:0030968)2.95639078
64histone H2A monoubiquitination (GO:0035518)2.94399566
65positive regulation of protein autophosphorylation (GO:0031954)2.93634930
66spindle checkpoint (GO:0031577)2.92390914
67chondrocyte development (GO:0002063)2.91808830
68negative regulation of axon extension involved in axon guidance (GO:0048843)2.91785777
69cell adhesion mediated by integrin (GO:0033627)2.90324561
70negative regulation of chondrocyte differentiation (GO:0032331)2.90264453
71water-soluble vitamin biosynthetic process (GO:0042364)2.89550081
72protein localization to kinetochore (GO:0034501)2.89226526
73regulation of mitotic spindle organization (GO:0060236)2.89214934
74protein neddylation (GO:0045116)2.89191946
75cellular response to unfolded protein (GO:0034620)2.87891750
76anterior/posterior axis specification, embryo (GO:0008595)2.86586342
77kinetochore organization (GO:0051383)2.86173710
78double-strand break repair via nonhomologous end joining (GO:0006303)2.85738861
79non-recombinational repair (GO:0000726)2.85738861
80protein K6-linked ubiquitination (GO:0085020)2.84683188
81regulation of RNA export from nucleus (GO:0046831)2.84068200
82dorsal/ventral axis specification (GO:0009950)2.83675598
83protein deneddylation (GO:0000338)2.82387067
84protein maturation by protein folding (GO:0022417)2.81188500
85UDP-N-acetylglucosamine metabolic process (GO:0006047)2.80472199
86insulin-like growth factor receptor signaling pathway (GO:0048009)2.77155806
87embryonic foregut morphogenesis (GO:0048617)2.77042722
88regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.75200694
89mitotic G2/M transition checkpoint (GO:0044818)2.74386111
90ER-nucleus signaling pathway (GO:0006984)2.73895800
91negative regulation of cartilage development (GO:0061037)2.72402679
92mitotic spindle checkpoint (GO:0071174)2.71948912
93folic acid-containing compound biosynthetic process (GO:0009396)2.71936272
94negative regulation of axon guidance (GO:1902668)2.71529438
95wound healing, spreading of epidermal cells (GO:0035313)2.70348161
96establishment of apical/basal cell polarity (GO:0035089)2.70175442
97axon extension involved in axon guidance (GO:0048846)2.70017090
98neuron projection extension involved in neuron projection guidance (GO:1902284)2.70017090
99ribosome assembly (GO:0042255)2.69861390
100cellular response to topologically incorrect protein (GO:0035967)2.68902758
101limb bud formation (GO:0060174)2.68839928
102kinetochore assembly (GO:0051382)2.66639231
103sequestering of extracellular ligand from receptor (GO:0035581)2.64190226
104DNA catabolic process, exonucleolytic (GO:0000738)2.64147072
105ventricular cardiac muscle cell development (GO:0055015)2.63456595
106glucocorticoid receptor signaling pathway (GO:0042921)2.63311986
107endocrine pancreas development (GO:0031018)2.63267885
108retina vasculature morphogenesis in camera-type eye (GO:0061299)2.62945569
109regulation of spindle organization (GO:0090224)2.61750394
110cell migration involved in sprouting angiogenesis (GO:0002042)2.61181156
111DNA ligation (GO:0006266)2.59619420
112regulation of mitotic metaphase/anaphase transition (GO:0030071)2.59065409
113regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.59065409
114artery development (GO:0060840)2.58578921
115epithelial cell-cell adhesion (GO:0090136)2.58245295
116maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.58010667
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.57280585
118negative regulation of sister chromatid segregation (GO:0033046)2.57280585
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57280585
120negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.57280585
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57280585
122notochord development (GO:0030903)2.56753179
123anterior/posterior axis specification (GO:0009948)2.55945093
124recombinational repair (GO:0000725)2.55877506
125DNA strand renaturation (GO:0000733)2.55657335
126double-strand break repair via homologous recombination (GO:0000724)2.55306283
127ganglion development (GO:0061548)2.54725698
128NLS-bearing protein import into nucleus (GO:0006607)2.53948421
129negative regulation of DNA recombination (GO:0045910)2.53577065
130somatic hypermutation of immunoglobulin genes (GO:0016446)2.52208566
131somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52208566
132somatic recombination of immunoglobulin gene segments (GO:0016447)2.51835434
133establishment of chromosome localization (GO:0051303)2.51152971
134negative regulation of keratinocyte proliferation (GO:0010839)2.50163790
135regulation of cell fate specification (GO:0042659)2.49795825
136negative regulation of chromosome segregation (GO:0051985)2.49287113
137G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.49019281
138mesodermal cell differentiation (GO:0048333)2.48156117
139craniofacial suture morphogenesis (GO:0097094)2.47969657
140postreplication repair (GO:0006301)2.47416763
141regulation of mitotic sister chromatid separation (GO:0010965)2.47403014
142regulation of mitotic sister chromatid segregation (GO:0033047)2.47403014
143regulation of sister chromatid segregation (GO:0033045)2.47403014
144lactate metabolic process (GO:0006089)2.47062704
145establishment of integrated proviral latency (GO:0075713)2.46702102
146body morphogenesis (GO:0010171)2.46299052
147negative regulation of DNA repair (GO:0045738)2.46098762
148embryonic body morphogenesis (GO:0010172)2.45627342
149regulation of chromosome segregation (GO:0051983)2.45436416
150histone H2A acetylation (GO:0043968)2.45094354
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44940742
152negative regulation of fatty acid transport (GO:2000192)2.44402883
153resolution of meiotic recombination intermediates (GO:0000712)2.44399310
154basement membrane organization (GO:0071711)2.44365254
155exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.44175561
156heterochromatin organization (GO:0070828)2.43781214
157positive regulation of glycoprotein biosynthetic process (GO:0010560)2.42538344
158apoptotic cell clearance (GO:0043277)2.42391627
159regulation of helicase activity (GO:0051095)2.42345565
160mitotic nuclear envelope disassembly (GO:0007077)2.41416292
161telomere maintenance via telomerase (GO:0007004)2.41388850
162regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.41286256
163vascular endothelial growth factor signaling pathway (GO:0038084)2.40195945
164hemidesmosome assembly (GO:0031581)2.39304858
165nuclear envelope disassembly (GO:0051081)2.38934384
166membrane disassembly (GO:0030397)2.38934384
167nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.38785836
168regulation of centrosome cycle (GO:0046605)2.38657752
169regulation of keratinocyte proliferation (GO:0010837)2.37870089
170regulation of type B pancreatic cell apoptotic process (GO:2000674)2.37695143
171regulation of nuclear cell cycle DNA replication (GO:0033262)2.37624321
172histone-serine phosphorylation (GO:0035404)2.37051769
173attachment of spindle microtubules to kinetochore (GO:0008608)2.36807984
174metanephric mesenchyme development (GO:0072075)2.36106436
175regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.35910068
176planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35718958
177regulation of centrosome duplication (GO:0010824)2.35610841
178establishment or maintenance of monopolar cell polarity (GO:0061339)2.34755418
179establishment of monopolar cell polarity (GO:0061162)2.34755418
180sister chromatid segregation (GO:0000819)2.34050544
181organ formation (GO:0048645)2.33831626
182mitotic spindle assembly checkpoint (GO:0007094)2.32843293
183cytoplasmic mRNA processing body assembly (GO:0033962)2.32423485
184regulation of hexokinase activity (GO:1903299)2.31950970
185regulation of glucokinase activity (GO:0033131)2.31950970
186ER overload response (GO:0006983)2.30648579
187response to endoplasmic reticulum stress (GO:0034976)2.29794264
188regulation of integrin-mediated signaling pathway (GO:2001044)2.29516624
189response to unfolded protein (GO:0006986)2.29132112
190regulation of transforming growth factor beta2 production (GO:0032909)2.28902711
191outer ear morphogenesis (GO:0042473)2.26168178
192positive regulation vascular endothelial growth factor production (GO:0010575)2.25899061
193protein hydroxylation (GO:0018126)2.25362741
194endocardial cushion development (GO:0003197)2.25189390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.81985471
2TP63_17297297_ChIP-ChIP_HaCaT_Human4.74718972
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.08271915
4E2F7_22180533_ChIP-Seq_HELA_Human4.02705583
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.80144830
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.43572097
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.18179499
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.07369792
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.81931683
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.79055727
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.76481502
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.70070255
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.55095507
14EWS_26573619_Chip-Seq_HEK293_Human2.36316587
15FUS_26573619_Chip-Seq_HEK293_Human2.34711111
16ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.34647383
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.33070499
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.30201105
19ZNF274_21170338_ChIP-Seq_K562_Hela2.23998027
20* BRD4_25478319_ChIP-Seq_HGPS_Human2.22400077
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.17899594
22AR_21909140_ChIP-Seq_LNCAP_Human2.17007577
23VDR_22108803_ChIP-Seq_LS180_Human2.15821782
24CLOCK_20551151_ChIP-Seq_293T_Human2.15212595
25P300_19829295_ChIP-Seq_ESCs_Human2.13424472
26GBX2_23144817_ChIP-Seq_PC3_Human2.12917004
27SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.07959382
28TP63_19390658_ChIP-ChIP_HaCaT_Human2.06638597
29TAF15_26573619_Chip-Seq_HEK293_Human2.00885511
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.96164248
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.95138846
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.94322007
33WT1_19549856_ChIP-ChIP_CCG9911_Human1.93799828
34SALL4_18804426_ChIP-ChIP_XEN_Mouse1.92792935
35IGF1R_20145208_ChIP-Seq_DFB_Human1.91696806
36CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.89616749
37SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.87223275
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.84387222
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.84219883
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.83917170
41* EST1_17652178_ChIP-ChIP_JURKAT_Human1.83712470
42CJUN_26792858_Chip-Seq_BT549_Human1.81688420
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.81355057
44TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.77037455
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.76048710
46HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75214212
47* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.73656110
48* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.73656110
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.70702431
50RARG_19884340_ChIP-ChIP_MEFs_Mouse1.65297420
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.65170970
52FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.64619539
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62920138
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.60824375
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.60033261
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58127849
57* PIAS1_25552417_ChIP-Seq_VCAP_Human1.52695670
58HIF1A_21447827_ChIP-Seq_MCF-7_Human1.52183530
59* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.51673533
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.48334753
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47927728
62MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46647115
63EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.43795284
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43473701
65ELK1_19687146_ChIP-ChIP_HELA_Human1.43399596
66* SMAD3_21741376_ChIP-Seq_EPCs_Human1.41499186
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.40967859
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.40216004
69TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38579352
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38082083
71ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.37912111
72CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.37491811
73TP53_16413492_ChIP-PET_HCT116_Human1.36889004
74* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.36548564
75SMAD4_21799915_ChIP-Seq_A2780_Human1.36455382
76UBF1/2_26484160_Chip-Seq_HMECs_Human1.34895638
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32305444
78MYC_18940864_ChIP-ChIP_HL60_Human1.32073388
79CHD1_26751641_Chip-Seq_LNCaP_Human1.31583685
80DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.31504291
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.31414525
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.31103961
83GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30510088
84FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.30250907
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.30010054
86PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29082012
87TFEB_21752829_ChIP-Seq_HELA_Human1.28083930
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27889741
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.27734304
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.27734304
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.27734304
92FOXO3_23340844_ChIP-Seq_DLD1_Human1.26721566
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26587665
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.26148130
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.25861027
96PKCTHETA_26484144_Chip-Seq_BREAST_Human1.24725261
97* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24642436
98* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24326259
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24257666
100* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.23676988
101ER_23166858_ChIP-Seq_MCF-7_Human1.23485924
102FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22682324
103TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21562227
104TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21442661
105SOX9_24532713_ChIP-Seq_HFSC_Mouse1.20706358
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.19506116
107* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.19484416
108* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.19484416
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.18733205
110KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.18342807
111PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17624914
112CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17042868
113ISL1_27105846_Chip-Seq_CPCs_Mouse1.16870637
114MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16800739
115TCF3_18692474_ChIP-Seq_MESCs_Mouse1.16610040
116BCAT_22108803_ChIP-Seq_LS180_Human1.16531564
117* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16355806
118CBP_20019798_ChIP-Seq_JUKART_Human1.16132807
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16132807
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.14531182
121CDX2_22108803_ChIP-Seq_LS180_Human1.12498210
122SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12202874
123FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.11943408
124SMAD_19615063_ChIP-ChIP_OVARY_Human1.11799433
125STAT3_23295773_ChIP-Seq_U87_Human1.11647756
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10846488
127PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09675168
128ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08727569
129* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08705727
130AR_25329375_ChIP-Seq_VCAP_Human1.08449840
131VDR_23849224_ChIP-Seq_CD4+_Human1.08359169
132* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07697149
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07473643
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.07142781
135SOX2_20726797_ChIP-Seq_SW620_Human1.06196605
136* TCF4_22108803_ChIP-Seq_LS180_Human1.06095415
137E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06029757
138* CRX_20693478_ChIP-Seq_RETINA_Mouse1.05823838
139EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05381510
140TBX3_20139965_ChIP-Seq_MESCs_Mouse1.05025373
141SOX2_16153702_ChIP-ChIP_HESCs_Human1.04546288
142ATF3_27146783_Chip-Seq_COLON_Human1.04526248
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.03268684
144P53_22387025_ChIP-Seq_ESCs_Mouse1.03255463
145STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03141024
146SMAD4_21741376_ChIP-Seq_EPCs_Human1.02854126
147NANOG_21062744_ChIP-ChIP_HESCs_Human1.02769814
148SOX2_19829295_ChIP-Seq_ESCs_Human1.02464830
149NANOG_19829295_ChIP-Seq_ESCs_Human1.02464830
150* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.02300738
151TCF4_18268006_ChIP-ChIP_LS174T_Human1.02276206
152SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.02207792
153NANOG_16153702_ChIP-ChIP_HESCs_Human1.02037311
154TBX3_20139965_ChIP-Seq_ESCs_Mouse1.01620575
155* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01577765
156NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.01495010
157GATA3_24758297_ChIP-Seq_MCF-7_Human1.01001548
158E2F1_18555785_Chip-Seq_ESCs_Mouse0.98761238
159* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.98019462
160TCF4_23295773_ChIP-Seq_U87_Human0.97971150
161P300_18555785_Chip-Seq_ESCs_Mouse0.96813493
162GATA6_25053715_ChIP-Seq_YYC3_Human0.96549801
163SUZ12_18555785_Chip-Seq_ESCs_Mouse0.96367734
164* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.95846826
165TP53_18474530_ChIP-ChIP_U2OS_Human0.95561569
166FOXM1_26456572_ChIP-Seq_MCF-7_Human0.95359773
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.94580708
168P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93638649
169MYC_18555785_ChIP-Seq_MESCs_Mouse0.93497582
170MYCN_18555785_ChIP-Seq_MESCs_Mouse0.93245601
171ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.93041357
172NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92844250

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen3.53624512
2MP0002877_abnormal_melanocyte_morpholog3.39536920
3MP0003705_abnormal_hypodermis_morpholog3.31001465
4MP0002102_abnormal_ear_morphology3.06831569
5MP0005275_abnormal_skin_tensile2.76493945
6MP0006292_abnormal_olfactory_placode2.73687426
7MP0010352_gastrointestinal_tract_polyps2.70216170
8MP0010094_abnormal_chromosome_stability2.49521673
9MP0003283_abnormal_digestive_organ2.44323576
10MP0004272_abnormal_basement_membrane2.36307716
11MP0005503_abnormal_tendon_morphology2.30103680
12MP0008877_abnormal_DNA_methylation2.28832685
13MP0008057_abnormal_DNA_replication2.22012217
14MP0010030_abnormal_orbit_morphology2.14550777
15MP0009780_abnormal_chondrocyte_physiolo2.08322805
16MP0003941_abnormal_skin_development2.06486726
17MP0003566_abnormal_cell_adhesion1.97320484
18MP0006054_spinal_hemorrhage1.96866200
19MP0008058_abnormal_DNA_repair1.93643498
20MP0010234_abnormal_vibrissa_follicle1.91632125
21MP0005076_abnormal_cell_differentiation1.90023399
22MP0000013_abnormal_adipose_tissue1.89624973
23MP0009384_cardiac_valve_regurgitation1.83668532
24MP0009697_abnormal_copulation1.79720177
25MP0000383_abnormal_hair_follicle1.76677708
26MP0002896_abnormal_bone_mineralization1.74502868
27MP0005623_abnormal_meninges_morphology1.74270533
28MP0003195_calcinosis1.72672983
29MP0005257_abnormal_intraocular_pressure1.65756023
30MP0009053_abnormal_anal_canal1.64332961
31MP0008932_abnormal_embryonic_tissue1.63445578
32MP0005367_renal/urinary_system_phenotyp1.61949730
33MP0000516_abnormal_urinary_system1.61949730
34MP0003123_paternal_imprinting1.60024040
35MP0001299_abnormal_eye_distance/1.59147875
36MP0002254_reproductive_system_inflammat1.58911866
37MP0000569_abnormal_digit_pigmentation1.56265812
38MP0008789_abnormal_olfactory_epithelium1.53994748
39MP0000647_abnormal_sebaceous_gland1.53805728
40MP0005508_abnormal_skeleton_morphology1.53424371
41MP0006072_abnormal_retinal_apoptosis1.52926064
42MP0003279_aneurysm1.52194723
43MP0003111_abnormal_nucleus_morphology1.48619938
44MP0004264_abnormal_extraembryonic_tissu1.47348345
45MP0002160_abnormal_reproductive_system1.44812872
46MP0000427_abnormal_hair_cycle1.44533917
47MP0003718_maternal_effect1.42937809
48MP0000428_abnormal_craniofacial_morphol1.41542312
49MP0003937_abnormal_limbs/digits/tail_de1.39225814
50MP0000003_abnormal_adipose_tissue1.38624795
51MP0005248_abnormal_Harderian_gland1.37911168
52MP0003787_abnormal_imprinting1.37718867
53MP0002751_abnormal_autonomic_nervous1.37659703
54MP0000537_abnormal_urethra_morphology1.36828305
55MP0001944_abnormal_pancreas_morphology1.36207117
56MP0003786_premature_aging1.35469313
57MP0003935_abnormal_craniofacial_develop1.34662868
58MP0010307_abnormal_tumor_latency1.33298115
59MP0003942_abnormal_urinary_system1.33116186
60MP0003385_abnormal_body_wall1.32046284
61MP0002234_abnormal_pharynx_morphology1.31282311
62MP0005023_abnormal_wound_healing1.30870256
63MP0003755_abnormal_palate_morphology1.30774135
64MP0000678_abnormal_parathyroid_gland1.30005209
65MP0004133_heterotaxia1.27737888
66MP0001286_abnormal_eye_development1.27703186
67MP0004197_abnormal_fetal_growth/weight/1.27466749
68MP0002060_abnormal_skin_morphology1.26611277
69MP0003890_abnormal_embryonic-extraembry1.24363284
70MP0000432_abnormal_head_morphology1.22911703
71MP0003077_abnormal_cell_cycle1.22854748
72MP0005499_abnormal_olfactory_system1.22418014
73MP0005394_taste/olfaction_phenotype1.22418014
74MP0003121_genomic_imprinting1.20265821
75MP0003567_abnormal_fetal_cardiomyocyte1.19878976
76MP0003119_abnormal_digestive_system1.18936032
77MP0002282_abnormal_trachea_morphology1.17562156
78MP0002084_abnormal_developmental_patter1.17421459
79MP0000733_abnormal_muscle_development1.17330847
80MP0005220_abnormal_exocrine_pancreas1.17214667
81MP0003300_gastrointestinal_ulcer1.16565886
82MP0000049_abnormal_middle_ear1.15732609
83MP0010368_abnormal_lymphatic_system1.14801872
84MP0001485_abnormal_pinna_reflex1.13733878
85MP0002736_abnormal_nociception_after1.13451887
86MP0003693_abnormal_embryo_hatching1.13171937
87MP0000372_irregular_coat_pigmentation1.12782073
88MP0001958_emphysema1.12140544
89MP0001188_hyperpigmentation1.11865553
90MP0000163_abnormal_cartilage_morphology1.11692596
91MP0001293_anophthalmia1.10063105
92MP0003091_abnormal_cell_migration1.09717995
93MP0002837_dystrophic_cardiac_calcinosis1.09153563
94MP0001177_atelectasis1.07816459
95MP0002693_abnormal_pancreas_physiology1.07546565
96MP0008007_abnormal_cellular_replicative1.05838835
97MP0005253_abnormal_eye_physiology1.03830588
98MP0002086_abnormal_extraembryonic_tissu1.03601055
99MP0000534_abnormal_ureter_morphology1.03220409
100MP0010386_abnormal_urinary_bladder1.03164420
101MP0004215_abnormal_myocardial_fiber1.02153368
102MP0003045_fibrosis1.02137986
103MP0002085_abnormal_embryonic_tissue1.01952419
104MP0001984_abnormal_olfaction1.01824915
105MP0003122_maternal_imprinting1.01760583
106MP0009703_decreased_birth_body1.01473997
107MP0001672_abnormal_embryogenesis/_devel1.00696702
108MP0005380_embryogenesis_phenotype1.00696702
109MP0002088_abnormal_embryonic_growth/wei0.99365905
110MP0003984_embryonic_growth_retardation0.99043189
111MP0004957_abnormal_blastocyst_morpholog0.98703431
112MP0002638_abnormal_pupillary_reflex0.98321865
113MP0001849_ear_inflammation0.97840914
114MP0002115_abnormal_skeleton_extremities0.97342530
115MP0002116_abnormal_craniofacial_bone0.97243592
116MP0009250_abnormal_appendicular_skeleto0.96849764
117MP0000613_abnormal_salivary_gland0.96545437
118MP0002928_abnormal_bile_duct0.96349652
119MP0002168_other_aberrant_phenotype0.96322333
120MP0001915_intracranial_hemorrhage0.94923343
121MP0002090_abnormal_vision0.94308306
122MP0002697_abnormal_eye_size0.94290473
123MP0001346_abnormal_lacrimal_gland0.93606112
124MP0002109_abnormal_limb_morphology0.93256297
125MP0002932_abnormal_joint_morphology0.93023145
126MP0002925_abnormal_cardiovascular_devel0.92060901
127MP0002098_abnormal_vibrissa_morphology0.91838937
128MP0002177_abnormal_outer_ear0.91563103
129MP0002111_abnormal_tail_morphology0.91099811
130MP0003115_abnormal_respiratory_system0.90735257
131MP0001697_abnormal_embryo_size0.90329209
132MP0010678_abnormal_skin_adnexa0.90291049
133MP0002233_abnormal_nose_morphology0.90103114
134MP0005389_reproductive_system_phenotype0.89866890
135MP0000579_abnormal_nail_morphology0.88421458
136MP0005187_abnormal_penis_morphology0.87980538
137MP0001529_abnormal_vocalization0.87822645
138MP0002108_abnormal_muscle_morphology0.87797249
139MP0005391_vision/eye_phenotype0.87444468
140MP0000566_synostosis0.87000568
141MP0005551_abnormal_eye_electrophysiolog0.85858793
142MP0002938_white_spotting0.84972643
143MP0000350_abnormal_cell_proliferation0.84832879
144MP0000462_abnormal_digestive_system0.84692443
145MP0001730_embryonic_growth_arrest0.82580006
146MP0002113_abnormal_skeleton_development0.82575465
147MP0000762_abnormal_tongue_morphology0.78223982
148MP0001119_abnormal_female_reproductive0.74937256
149MP0005084_abnormal_gallbladder_morpholo0.74796027
150MP0001661_extended_life_span0.74052836
151MP0002092_abnormal_eye_morphology0.72384491
152MP0000467_abnormal_esophagus_morphology0.72194387

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.04402053
2Premature rupture of membranes (HP:0001788)4.03646599
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.31720602
4Cervical subluxation (HP:0003308)3.31645961
5Atrophic scars (HP:0001075)3.16136962
6Chromsome breakage (HP:0040012)3.13901280
7Abnormality of chromosome stability (HP:0003220)3.12120420
8Shallow orbits (HP:0000586)3.11614393
9Aplasia/Hypoplasia of the uvula (HP:0010293)3.05255630
10Meckel diverticulum (HP:0002245)2.99855482
11Ankle contracture (HP:0006466)2.94352460
12Abnormality of the ileum (HP:0001549)2.92301648
13Stenosis of the external auditory canal (HP:0000402)2.81928664
14Soft skin (HP:0000977)2.74874143
15Hypoplastic labia majora (HP:0000059)2.73288418
16Hypoglycemic seizures (HP:0002173)2.67930569
17Bifid tongue (HP:0010297)2.67607634
18Hyperinsulinemic hypoglycemia (HP:0000825)2.61200500
19Cerebral aneurysm (HP:0004944)2.59713252
20Abnormal lung lobation (HP:0002101)2.59639771
21Hyperglycemia (HP:0003074)2.55231913
22Insulin-resistant diabetes mellitus (HP:0000831)2.52513571
23Abnormality of the preputium (HP:0100587)2.52091776
24Duodenal stenosis (HP:0100867)2.49393553
25Small intestinal stenosis (HP:0012848)2.49393553
26Ependymoma (HP:0002888)2.49259612
27Abnormality of the labia majora (HP:0012881)2.42548367
28Broad face (HP:0000283)2.41644882
29Abnormality of the duodenum (HP:0002246)2.40436599
30Intestinal atresia (HP:0011100)2.39667616
31Pancreatic cysts (HP:0001737)2.38211413
32Methylmalonic acidemia (HP:0002912)2.35216019
33Aortic aneurysm (HP:0004942)2.34468980
34Ectopic kidney (HP:0000086)2.30671629
35Abnormality of the labia minora (HP:0012880)2.30006000
36Missing ribs (HP:0000921)2.29113333
37Hypoplastic ischia (HP:0003175)2.29109324
38Abnormality of the fetal cardiovascular system (HP:0010948)2.28178793
39Abnormal umbilical cord blood vessels (HP:0011403)2.28178793
40Single umbilical artery (HP:0001195)2.28178793
41Aplasia/Hypoplasia of the fovea (HP:0008060)2.27851109
42Hypoplasia of the fovea (HP:0007750)2.27851109
43Pancreatic fibrosis (HP:0100732)2.26629496
44Aortic dissection (HP:0002647)2.25795965
45Absent radius (HP:0003974)2.25121564
46Rhabdomyosarcoma (HP:0002859)2.24165680
47Spondylolisthesis (HP:0003302)2.23939670
48Volvulus (HP:0002580)2.22854377
49Dilatation of the ascending aorta (HP:0005111)2.21307960
50Symptomatic seizures (HP:0011145)2.19072764
51Aplasia/Hypoplasia of the tibia (HP:0005772)2.17829625
52Fragile skin (HP:0001030)2.17634441
53Exostoses (HP:0100777)2.17094360
54Hypoglycemic coma (HP:0001325)2.16768044
55Aplasia involving forearm bones (HP:0009822)2.14999852
56Absent forearm bone (HP:0003953)2.14999852
57Short tibia (HP:0005736)2.14272651
58Bladder diverticulum (HP:0000015)2.12668244
59Wormian bones (HP:0002645)2.11550182
60Abnormality of methionine metabolism (HP:0010901)2.10628247
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.09559646
62Neoplasm of the adrenal cortex (HP:0100641)2.08826748
63Glioma (HP:0009733)2.08563279
64Macroorchidism (HP:0000053)2.08288182
65Abnormality of dentin (HP:0010299)2.08192453
66Abnormality of the nasal septum (HP:0000419)2.07945452
67Aneurysm (HP:0002617)2.07799266
68Broad thumb (HP:0011304)2.07483803
69Papillary thyroid carcinoma (HP:0002895)2.06892290
70Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05215336
71True hermaphroditism (HP:0010459)2.03923600
72Hepatoblastoma (HP:0002884)2.03537483
73Abnormality of the ischium (HP:0003174)2.03356336
74Short hallux (HP:0010109)2.02998928
75Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.02498073
76Short 4th metacarpal (HP:0010044)2.02498073
77Genital tract atresia (HP:0001827)2.02099775
78Abnormality of the fovea (HP:0000493)2.00877624
79Aplasia/Hypoplasia of the hallux (HP:0008362)1.99623354
80Hypoplastic pelvis (HP:0008839)1.99595450
81Embryonal renal neoplasm (HP:0011794)1.99392213
82Broad long bones (HP:0005622)1.98969278
83Abnormal pancreas size (HP:0012094)1.98807746
84Aplasia/Hypoplasia of the tongue (HP:0010295)1.97775024
85Anophthalmia (HP:0000528)1.97687845
86Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.97305872
87Genu recurvatum (HP:0002816)1.96681405
88Blue sclerae (HP:0000592)1.94736906
89Neoplasm of the adrenal gland (HP:0100631)1.93036277
90Small hand (HP:0200055)1.92416408
91Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91843911
92Abnormality of the distal phalanges of the toes (HP:0010182)1.91676739
93Aplasia/hypoplasia of the humerus (HP:0006507)1.91532781
94Thoracolumbar scoliosis (HP:0002944)1.91511446
95Bowel diverticulosis (HP:0005222)1.91443517
96Vaginal atresia (HP:0000148)1.91382539
97Adrenal hypoplasia (HP:0000835)1.91127986
98Sloping forehead (HP:0000340)1.90443474
99Septo-optic dysplasia (HP:0100842)1.90024493
100Nephroblastoma (Wilms tumor) (HP:0002667)1.89423317
101Aqueductal stenosis (HP:0002410)1.89323289
102Flat capital femoral epiphysis (HP:0003370)1.88364543
103Rectal prolapse (HP:0002035)1.87742815
104Mesomelia (HP:0003027)1.87524175
105Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.87173692
106Vascular tortuosity (HP:0004948)1.86854342
107Triphalangeal thumb (HP:0001199)1.86728301
108Biliary tract neoplasm (HP:0100574)1.86012883
109Lip pit (HP:0100267)1.85823064
110Clubbing of toes (HP:0100760)1.84645448
111Broad phalanx (HP:0006009)1.84317857
112Preaxial hand polydactyly (HP:0001177)1.84221519
113Mitral valve prolapse (HP:0001634)1.84140703
114Renal cortical cysts (HP:0000803)1.83929357
115Molar tooth sign on MRI (HP:0002419)1.83617194
116Abnormality of midbrain morphology (HP:0002418)1.83617194
117Short nail (HP:0001799)1.83540034
118Thin bony cortex (HP:0002753)1.82178276
119Optic nerve hypoplasia (HP:0000609)1.82142047
120Horseshoe kidney (HP:0000085)1.81828108
121Labial hypoplasia (HP:0000066)1.81707865
122Joint laxity (HP:0001388)1.81552769
123Abnormality of the carotid arteries (HP:0005344)1.80373217
124Hypoplastic female external genitalia (HP:0012815)1.80206935
125Overgrowth (HP:0001548)1.80136194
126Breast carcinoma (HP:0003002)1.80111614
127Peritonitis (HP:0002586)1.80088441
128Hyperglycinemia (HP:0002154)1.78433567
129Tibial bowing (HP:0002982)1.78311314
130Broad phalanges of the hand (HP:0009768)1.77638985
131Spinal cord lesions (HP:0100561)1.75174422
132Syringomyelia (HP:0003396)1.75174422
133Spinal rigidity (HP:0003306)1.75159479
134Median cleft lip (HP:0000161)1.75123132
135Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.74800012
136Short 1st metacarpal (HP:0010034)1.74800012
137Abnormality of the phalanges of the 5th finger (HP:0004213)1.74580577
138Natal tooth (HP:0000695)1.73649018
139Follicular hyperkeratosis (HP:0007502)1.72714406
140Wrist flexion contracture (HP:0001239)1.72587606
141Neonatal short-limb short stature (HP:0008921)1.72271983
142Abnormality of the umbilical cord (HP:0010881)1.71849401
143Shawl scrotum (HP:0000049)1.71318405
144Long eyelashes (HP:0000527)1.71022815
145Selective tooth agenesis (HP:0001592)1.70304567
146Sensory axonal neuropathy (HP:0003390)1.70263180
147Supernumerary spleens (HP:0009799)1.69979889
148Oligodactyly (hands) (HP:0001180)1.69336233
149Abnormality of the proximal phalanges of the hand (HP:0009834)1.69044898
150Spinal cord compression (HP:0002176)1.68536418
151Arterial tortuosity (HP:0005116)1.68507048
152Renal hypoplasia (HP:0000089)1.68243966
153Dandy-Walker malformation (HP:0001305)1.68037334
154Disproportionate short-trunk short stature (HP:0003521)1.67657188
155Abnormality of serum amino acid levels (HP:0003112)1.67507777
156Myelomeningocele (HP:0002475)1.66973931
157Medial flaring of the eyebrow (HP:0010747)1.66261379
158Synostosis of carpal bones (HP:0005048)1.66188915
159Bilateral microphthalmos (HP:0007633)1.65802137
160Malignant gastrointestinal tract tumors (HP:0006749)1.65713354
161Gastrointestinal carcinoma (HP:0002672)1.65713354
162Gastrointestinal atresia (HP:0002589)1.65335345
163Broad finger (HP:0001500)1.65177448
164Abnormality of the astrocytes (HP:0100707)1.65166105
165Astrocytoma (HP:0009592)1.65166105
166Preaxial foot polydactyly (HP:0001841)1.64482518
167Short middle phalanx of the 5th finger (HP:0004220)1.64418868
168Abnormal biliary tract morphology (HP:0012440)1.64367311
169Abnormal vertebral ossification (HP:0100569)1.64364570
170Deviation of the thumb (HP:0009603)1.64328596
171Absent eyebrow (HP:0002223)1.63634528
172Abnormality of the acetabulum (HP:0003170)1.63312775
173Abnormality of the renal cortex (HP:0011035)1.62958243
174Bell-shaped thorax (HP:0001591)1.62790850
175Abnormality of the parathyroid morphology (HP:0011766)1.62751676
176Methylmalonic aciduria (HP:0012120)1.61539874
177Nephronophthisis (HP:0000090)1.61114256
178Subacute progressive viral hepatitis (HP:0006572)1.60230790
17911 pairs of ribs (HP:0000878)1.58232508
180Hyperextensible skin (HP:0000974)1.58162367
181Radial bowing (HP:0002986)1.57750222
182Cutaneous finger syndactyly (HP:0010554)1.57359652
183Colon cancer (HP:0003003)1.56480907
184Short humerus (HP:0005792)1.55605203
185Chorioretinal atrophy (HP:0000533)1.55185879
186Decreased skull ossification (HP:0004331)1.54473422
187Abnormality of the distal phalanx of the thumb (HP:0009617)1.53474475
188Deep philtrum (HP:0002002)1.52702917
189Pancreatic islet-cell hyperplasia (HP:0004510)1.52537069
190Abnormality of the frontal sinuses (HP:0002687)1.52273376

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.50280834
2CDK123.66729228
3TRIM283.34545882
4INSRR3.08452297
5PASK2.97603168
6FRK2.89692973
7EPHA22.89257491
8MKNK22.81707348
9MST42.70873935
10EIF2AK32.63500677
11BUB12.49277230
12WEE12.34638732
13DDR22.34109831
14PDGFRA2.31929784
15TNIK2.01945119
16BRSK22.01805349
17PBK1.97286724
18STK31.87679601
19SCYL21.83863670
20TTN1.82925531
21EIF2AK11.75842301
22PTK61.74960090
23TSSK61.73099742
24STK38L1.72894608
25BRD41.71454524
26MET1.70655873
27STK391.70392647
28PTK21.65734834
29MAP3K21.62871139
30CDC71.57721473
31CDK61.46145216
32LATS21.44713269
33CASK1.41865400
34ERBB31.41384959
35SIK11.38973495
36ZAK1.36837585
37FER1.35741306
38FLT31.35235560
39RPS6KA41.33829014
40GRK11.30503950
41NUAK11.25929659
42MTOR1.25741363
43MAP4K21.25352164
44AKT31.24379040
45PRKD31.24290925
46FGFR11.23599554
47EPHB21.21427504
48TTK1.21378854
49MAP3K31.20383352
50OXSR11.20283289
51PLK31.16750693
52TAF11.15703172
53PNCK1.14407428
54EPHA31.13593184
55CSNK1G11.12092863
56TRIB31.05780491
57TGFBR11.05102515
58PAK21.04253634
59EIF2AK21.03391607
60CAMK1D0.99808507
61MAPK150.97520266
62STK160.96146163
63ERN10.94957553
64MAPK130.93836719
65ERBB40.93382029
66PAK30.90106609
67TIE10.90058884
68MELK0.87266720
69CSNK1G20.85429217
70BCR0.84667627
71SIK30.83713182
72TAOK30.83619555
73MAP3K120.82500841
74VRK10.82224391
75CDC42BPA0.81407487
76PKN20.80766589
77CSNK1G30.80424237
78DMPK0.80181683
79HIPK20.79297702
80CHEK20.78862678
81TESK10.77700728
82NEK20.77327722
83ATM0.77324309
84RIPK10.77282484
85TRPM70.76976298
86NEK90.76526696
87PDGFRB0.76231247
88AURKB0.75558505
89TAOK20.75376792
90MAP3K40.73584198
91PRKCE0.73467239
92ACVR1B0.72621935
93PLK10.70654133
94RPS6KB20.66982317
95STK240.66936087
96ATR0.66530075
97MAP3K80.65948150
98DYRK1B0.64859824
99CSNK1A1L0.64575789
100BMX0.62668840
101CHEK10.62360554
102WNK10.61764482
103CDK90.61327420
104PAK40.60691549
105CHUK0.60458894
106CDK70.60161759
107NEK10.59853215
108CAMKK20.57516949
109PLK40.57145263
110SRPK10.55519541
111STK100.55417751
112PDK20.55050882
113CDK80.51785253
114TGFBR20.51153516
115MINK10.50742041
116NLK0.50336057
117PINK10.50190663
118WNK30.50011297
119CDK30.49990298
120LRRK20.49304753
121BMPR1B0.48979260
122ERBB20.48897745
123PRKCI0.48743636
124ADRBK20.47774751
125EPHA40.47736477
126PRKDC0.45955409
127PLK20.45686288
128PRKCG0.44780429
129VRK20.44146702
130ADRBK10.43445860
131PIK3CG0.42835430
132FGFR30.41650473
133CDK20.41580287
134CAMK1G0.41325322
135CDK10.40209254
136MYLK0.40063118
137MAPK10.39286213
138ALK0.38773888
139MAPK140.38641858
140MKNK10.38097686
141FGFR20.37581545
142BRSK10.37301264
143CDK40.36413412
144LIMK10.31766271
145PTK2B0.31656047
146ROCK10.31584212
147CSNK2A10.28931268
148MAP2K70.28045871
149WNK40.27258758
150CSNK1A10.25880596
151CSNK1E0.25847716
152CAMK2A0.25024348
153CSNK1D0.24783874
154TLK10.22643320

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.37318796
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.92151767
3Proteasome_Homo sapiens_hsa030502.83915290
4Protein export_Homo sapiens_hsa030602.63627079
5ECM-receptor interaction_Homo sapiens_hsa045122.56687644
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.44720791
7Adherens junction_Homo sapiens_hsa045202.37020578
8Propanoate metabolism_Homo sapiens_hsa006402.24135002
9Steroid biosynthesis_Homo sapiens_hsa001002.23869810
10Homologous recombination_Homo sapiens_hsa034402.22013712
11Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.02628031
12Basal transcription factors_Homo sapiens_hsa030222.02429011
13p53 signaling pathway_Homo sapiens_hsa041152.01485448
14Focal adhesion_Homo sapiens_hsa045101.96185464
15MicroRNAs in cancer_Homo sapiens_hsa052061.89862415
16Vitamin B6 metabolism_Homo sapiens_hsa007501.84495111
17Cell cycle_Homo sapiens_hsa041101.81130467
18Small cell lung cancer_Homo sapiens_hsa052221.80485133
19DNA replication_Homo sapiens_hsa030301.79084570
20Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78850322
21Hippo signaling pathway_Homo sapiens_hsa043901.78687406
22Bladder cancer_Homo sapiens_hsa052191.73822715
23TGF-beta signaling pathway_Homo sapiens_hsa043501.73420584
24Proteoglycans in cancer_Homo sapiens_hsa052051.73269528
25Nucleotide excision repair_Homo sapiens_hsa034201.57311321
26RNA polymerase_Homo sapiens_hsa030201.55636872
27Prostate cancer_Homo sapiens_hsa052151.51727768
28Basal cell carcinoma_Homo sapiens_hsa052171.49022134
29Fatty acid elongation_Homo sapiens_hsa000621.48118536
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.46566361
31Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46175167
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.45323159
33Cysteine and methionine metabolism_Homo sapiens_hsa002701.44078183
34Selenocompound metabolism_Homo sapiens_hsa004501.43297343
35Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.40804409
36Pyruvate metabolism_Homo sapiens_hsa006201.39991991
37N-Glycan biosynthesis_Homo sapiens_hsa005101.36665061
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.35220354
39Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.34725574
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.34702751
41RNA transport_Homo sapiens_hsa030131.34216474
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33698846
43Thyroid cancer_Homo sapiens_hsa052161.29859063
44Hedgehog signaling pathway_Homo sapiens_hsa043401.28568030
45Protein digestion and absorption_Homo sapiens_hsa049741.28565354
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.27096787
47mTOR signaling pathway_Homo sapiens_hsa041501.26769229
48Type II diabetes mellitus_Homo sapiens_hsa049301.23138006
49Lysine degradation_Homo sapiens_hsa003101.16403842
50Endometrial cancer_Homo sapiens_hsa052131.16269800
51Amoebiasis_Homo sapiens_hsa051461.16056321
52Sulfur metabolism_Homo sapiens_hsa009201.15212690
53Melanoma_Homo sapiens_hsa052181.14717587
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.14497502
55PI3K-Akt signaling pathway_Homo sapiens_hsa041511.14483980
56Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.13621616
57Phototransduction_Homo sapiens_hsa047441.12192729
58Chronic myeloid leukemia_Homo sapiens_hsa052201.11933281
59One carbon pool by folate_Homo sapiens_hsa006701.11226593
60Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08706582
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08545925
62Butanoate metabolism_Homo sapiens_hsa006501.06266165
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.05232970
64Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01473443
65Insulin secretion_Homo sapiens_hsa049111.00491497
66FoxO signaling pathway_Homo sapiens_hsa040680.99788348
67Tight junction_Homo sapiens_hsa045300.99251143
68Viral carcinogenesis_Homo sapiens_hsa052030.97974304
69Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.97488598
70HTLV-I infection_Homo sapiens_hsa051660.95711922
71Wnt signaling pathway_Homo sapiens_hsa043100.95096680
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94297684
73Dilated cardiomyopathy_Homo sapiens_hsa054140.93992620
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.93899209
75Base excision repair_Homo sapiens_hsa034100.93628020
76Insulin resistance_Homo sapiens_hsa049310.92350392
77Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.92102684
78Glutathione metabolism_Homo sapiens_hsa004800.92090440
79Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91624410
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.91217193
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.90395183
82Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.90298950
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89464970
84Pathways in cancer_Homo sapiens_hsa052000.89271339
85Lysosome_Homo sapiens_hsa041420.87771775
86Purine metabolism_Homo sapiens_hsa002300.86628357
87Pancreatic cancer_Homo sapiens_hsa052120.86528175
88Nitrogen metabolism_Homo sapiens_hsa009100.85407109
89Colorectal cancer_Homo sapiens_hsa052100.83401124
90Pyrimidine metabolism_Homo sapiens_hsa002400.82933885
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82876824
92Type I diabetes mellitus_Homo sapiens_hsa049400.82301659
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.80521205
94Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79251047
95Tryptophan metabolism_Homo sapiens_hsa003800.79057255
96mRNA surveillance pathway_Homo sapiens_hsa030150.77259663
97Fatty acid metabolism_Homo sapiens_hsa012120.76653921
98Prolactin signaling pathway_Homo sapiens_hsa049170.76210788
99Peroxisome_Homo sapiens_hsa041460.75801141
100Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73693247
101Thyroid hormone synthesis_Homo sapiens_hsa049180.72539158
102Retinol metabolism_Homo sapiens_hsa008300.72300105
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72254860
104Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71948496
105Fanconi anemia pathway_Homo sapiens_hsa034600.70810815
106Fatty acid degradation_Homo sapiens_hsa000710.69340406
107RNA degradation_Homo sapiens_hsa030180.69280480
108Vibrio cholerae infection_Homo sapiens_hsa051100.68836784
109Spliceosome_Homo sapiens_hsa030400.68813395
110Glucagon signaling pathway_Homo sapiens_hsa049220.67755612
111beta-Alanine metabolism_Homo sapiens_hsa004100.67382286
112Toxoplasmosis_Homo sapiens_hsa051450.66223801
113TNF signaling pathway_Homo sapiens_hsa046680.65936337
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65436967
115Renal cell carcinoma_Homo sapiens_hsa052110.65285446
116Leukocyte transendothelial migration_Homo sapiens_hsa046700.65282138
117Vitamin digestion and absorption_Homo sapiens_hsa049770.65281991
118Glioma_Homo sapiens_hsa052140.65269765
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.63630665
120Caffeine metabolism_Homo sapiens_hsa002320.62488323
121Renin-angiotensin system_Homo sapiens_hsa046140.62446706
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62194556
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62055819
124Legionellosis_Homo sapiens_hsa051340.60083911
125Oxidative phosphorylation_Homo sapiens_hsa001900.58966045
126Primary bile acid biosynthesis_Homo sapiens_hsa001200.58096779
127Metabolic pathways_Homo sapiens_hsa011000.58086859
128Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.57459437
129Dorso-ventral axis formation_Homo sapiens_hsa043200.57087905
130Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56070142
131Hepatitis B_Homo sapiens_hsa051610.55977046
132Estrogen signaling pathway_Homo sapiens_hsa049150.55321323
133AMPK signaling pathway_Homo sapiens_hsa041520.55159805
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.54364550
135Circadian rhythm_Homo sapiens_hsa047100.53841146
136Ovarian steroidogenesis_Homo sapiens_hsa049130.53441981
137Folate biosynthesis_Homo sapiens_hsa007900.53389417
138Rap1 signaling pathway_Homo sapiens_hsa040150.53347785
139Melanogenesis_Homo sapiens_hsa049160.51681397
140Antigen processing and presentation_Homo sapiens_hsa046120.51422992
141Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50127037
142Parkinsons disease_Homo sapiens_hsa050120.49969808
143Oocyte meiosis_Homo sapiens_hsa041140.48870687
144Chemical carcinogenesis_Homo sapiens_hsa052040.48399249
145Huntingtons disease_Homo sapiens_hsa050160.47775861
146Carbon metabolism_Homo sapiens_hsa012000.47653870
147Steroid hormone biosynthesis_Homo sapiens_hsa001400.47166194
148Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.45287106
149Insulin signaling pathway_Homo sapiens_hsa049100.44594715
150Ether lipid metabolism_Homo sapiens_hsa005650.44087542
151Non-homologous end-joining_Homo sapiens_hsa034500.43818570
152Prion diseases_Homo sapiens_hsa050200.41907709
153Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41906941
154Regulation of autophagy_Homo sapiens_hsa041400.41899909
155Sphingolipid metabolism_Homo sapiens_hsa006000.40460277
156Neurotrophin signaling pathway_Homo sapiens_hsa047220.40452085
157Notch signaling pathway_Homo sapiens_hsa043300.40090226
158Apoptosis_Homo sapiens_hsa042100.39455785
159Nicotine addiction_Homo sapiens_hsa050330.39354947
160Other glycan degradation_Homo sapiens_hsa005110.39111538
161Mismatch repair_Homo sapiens_hsa034300.37542004
162Biosynthesis of amino acids_Homo sapiens_hsa012300.36848795
163Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.34329831
164Axon guidance_Homo sapiens_hsa043600.32435572
165Glycerolipid metabolism_Homo sapiens_hsa005610.30991503
166Olfactory transduction_Homo sapiens_hsa047400.30298977

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