TMTC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an integral membrane protein localized to the endoplasmic reticulum (ER). The encoded protein contains many tetratricopeptide repeats, sequences known for being involved in protein-protein interactions. This protein binds both the calcium uptake pump SERCA2B and the carbohydrate-binding chaperone calnexin, and it appears to play a role in calcium homeostasis in the ER. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1detection of light stimulus involved in sensory perception (GO:0050962)4.63536794
2detection of light stimulus involved in visual perception (GO:0050908)4.63536794
3response to pheromone (GO:0019236)4.34564709
4negative regulation of cytosolic calcium ion concentration (GO:0051481)4.18801694
5metanephric mesenchyme development (GO:0072075)4.16494035
6retinal rod cell development (GO:0046548)4.09329117
7generation of neurons (GO:0048699)3.97104159
8planar cell polarity pathway involved in neural tube closure (GO:0090179)3.82332796
9regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.69573296
10photoreceptor cell differentiation (GO:0046530)3.66495930
11eye photoreceptor cell differentiation (GO:0001754)3.66495930
12presynaptic membrane assembly (GO:0097105)3.63276447
13presynaptic membrane organization (GO:0097090)3.61102297
14establishment of nucleus localization (GO:0040023)3.60989919
15kidney mesenchyme development (GO:0072074)3.52938806
16axon ensheathment in central nervous system (GO:0032291)3.44070299
17central nervous system myelination (GO:0022010)3.44070299
18cranial nerve morphogenesis (GO:0021602)3.34685014
19limb development (GO:0060173)3.33329130
20appendage development (GO:0048736)3.33329130
21negative regulation of catenin import into nucleus (GO:0035414)3.29199203
22axon extension involved in axon guidance (GO:0048846)3.28203818
23neuron projection extension involved in neuron projection guidance (GO:1902284)3.28203818
24potassium ion homeostasis (GO:0055075)3.27493196
25peptidyl-tyrosine autophosphorylation (GO:0038083)3.22590316
26sodium ion export (GO:0071436)3.21809370
27mating behavior (GO:0007617)3.17745401
28proximal/distal pattern formation (GO:0009954)3.15752390
29cellular potassium ion homeostasis (GO:0030007)3.12612868
30central nervous system projection neuron axonogenesis (GO:0021952)3.10116073
31innervation (GO:0060384)3.08006496
32peripheral nervous system neuron development (GO:0048935)3.05143851
33lateral sprouting from an epithelium (GO:0060601)3.05122431
34G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.98714285
35Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94996458
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.94099664
37G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.91316457
38regulation of establishment of planar polarity (GO:0090175)2.91027038
39synaptic vesicle docking involved in exocytosis (GO:0016081)2.89512193
40regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.88209341
41postsynaptic membrane organization (GO:0001941)2.84958695
42nephron tubule formation (GO:0072079)2.83860016
43calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.83203008
44regulation of secondary heart field cardioblast proliferation (GO:0003266)2.82059110
45regulation of cardioblast proliferation (GO:0003264)2.82059110
46astrocyte development (GO:0014002)2.81042744
47apical protein localization (GO:0045176)2.79942213
48axon extension (GO:0048675)2.79073841
49relaxation of smooth muscle (GO:0044557)2.73796591
50developmental induction (GO:0031128)2.72934488
51segment specification (GO:0007379)2.70985900
52locomotory exploration behavior (GO:0035641)2.68208686
53organ induction (GO:0001759)2.62624109
54negative regulation of neurotransmitter secretion (GO:0046929)2.62610795
55cell-cell signaling involved in cell fate commitment (GO:0045168)2.62060220
56layer formation in cerebral cortex (GO:0021819)2.59730209
57synapse assembly (GO:0007416)2.59143713
58substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.58946536
59substrate-independent telencephalic tangential migration (GO:0021826)2.58946536
60neuronal ion channel clustering (GO:0045161)2.58215284
61dendrite morphogenesis (GO:0048813)2.56492535
62regulation of synapse assembly (GO:0051963)2.56265885
63cerebral cortex radially oriented cell migration (GO:0021799)2.55200430
64axon ensheathment (GO:0008366)2.54040696
65ensheathment of neurons (GO:0007272)2.54040696
66myelination (GO:0042552)2.53626502
67fatty acid elongation (GO:0030497)2.51602721
68homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.50631658
69suckling behavior (GO:0001967)2.50599077
70central nervous system neuron axonogenesis (GO:0021955)2.49160095
71non-canonical Wnt signaling pathway (GO:0035567)2.48910740
72positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.46703733
73ionotropic glutamate receptor signaling pathway (GO:0035235)2.46212391
74cilium or flagellum-dependent cell motility (GO:0001539)2.45517385
75cochlea morphogenesis (GO:0090103)2.44849391
76pharyngeal system development (GO:0060037)2.44728620
77glomerular filtration (GO:0003094)2.44514796
78neuron cell-cell adhesion (GO:0007158)2.43486327
79negative chemotaxis (GO:0050919)2.43429389
80synaptic vesicle maturation (GO:0016188)2.43063870
81positive regulation of gastrulation (GO:2000543)2.42183644
82asymmetric protein localization (GO:0008105)2.40879072
83myelination in peripheral nervous system (GO:0022011)2.40473171
84peripheral nervous system axon ensheathment (GO:0032292)2.40473171
85neuron projection extension (GO:1990138)2.40325775
86negative regulation of axon extension involved in axon guidance (GO:0048843)2.39403347
87peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.38914779
88long-chain fatty acid biosynthetic process (GO:0042759)2.37842575
89retina layer formation (GO:0010842)2.37675750
90vocalization behavior (GO:0071625)2.37590289
91cytoskeletal anchoring at plasma membrane (GO:0007016)2.37489585
92glutamate secretion (GO:0014047)2.37068781
93embryonic retina morphogenesis in camera-type eye (GO:0060059)2.36880234
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.36672862
95regulation of bile acid biosynthetic process (GO:0070857)2.35589937
96gamma-aminobutyric acid signaling pathway (GO:0007214)2.34221216
97retinal ganglion cell axon guidance (GO:0031290)2.33978451
98paraxial mesoderm development (GO:0048339)2.33550201
99semaphorin-plexin signaling pathway (GO:0071526)2.33395016
100regulation of synaptic vesicle exocytosis (GO:2000300)2.33305504
101establishment of planar polarity (GO:0001736)2.32813367
102establishment of tissue polarity (GO:0007164)2.32813367
103myoblast migration (GO:0051451)2.32408497
104nucleus localization (GO:0051647)2.32195181
105cellular sodium ion homeostasis (GO:0006883)2.32181253
106regulation of NFAT protein import into nucleus (GO:0051532)2.31484069
107photoreceptor cell maintenance (GO:0045494)2.31331852
108axonal fasciculation (GO:0007413)2.31266385
109regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.30193528
110muscle cell proliferation (GO:0033002)2.30189976
111pyrimidine nucleobase catabolic process (GO:0006208)2.29961371
112developmental growth involved in morphogenesis (GO:0060560)2.29346682
113developmental cell growth (GO:0048588)2.28924127
114regulation of cardioblast differentiation (GO:0051890)2.28507089
115ganglion development (GO:0061548)2.28469931
116neuromuscular process controlling balance (GO:0050885)2.28254754
117negative regulation of axon guidance (GO:1902668)2.28055759
118negative regulation of chondrocyte differentiation (GO:0032331)2.28004028
119eye morphogenesis (GO:0048592)2.27009428
120membrane hyperpolarization (GO:0060081)2.26815597
121prepulse inhibition (GO:0060134)2.26560916
122synaptic vesicle exocytosis (GO:0016079)2.26481437
123neuron recognition (GO:0008038)2.25278474
124cell differentiation involved in metanephros development (GO:0072202)2.24218045
125regulation of neuronal synaptic plasticity (GO:0048168)2.23499838
126axonogenesis (GO:0007409)2.22718792
127erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.22439600
128L-phenylalanine catabolic process (GO:0006559)2.22439600
129limb bud formation (GO:0060174)2.22348454
130negative regulation of neurotransmitter transport (GO:0051589)2.22271067
131synaptic vesicle endocytosis (GO:0048488)2.21827164
132regulation of axon extension involved in axon guidance (GO:0048841)2.21387197
133calcium ion import (GO:0070509)2.19556417
134mesenchyme morphogenesis (GO:0072132)2.19331594
135regulation of axon guidance (GO:1902667)2.16164187
136detection of temperature stimulus (GO:0016048)2.15661872
137endocardial cushion morphogenesis (GO:0003203)2.15538808
138regulation of voltage-gated calcium channel activity (GO:1901385)2.14914383
139regulation of transforming growth factor beta2 production (GO:0032909)2.14721778
140midgut development (GO:0007494)2.14287486
141detection of temperature stimulus involved in sensory perception (GO:0050961)2.11925305
142detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.11925305
143cell migration in hindbrain (GO:0021535)2.11489339
144protein localization to synapse (GO:0035418)2.11055484
145renal filtration (GO:0097205)2.10806200
146atrial cardiac muscle cell action potential (GO:0086014)2.10359893
147cell communication by electrical coupling (GO:0010644)2.10266075
148estrogen biosynthetic process (GO:0006703)2.10152693
149positive regulation of synapse maturation (GO:0090129)2.07068229
150membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.06450146
151behavioral response to cocaine (GO:0048148)2.05904288
152regulation of short-term neuronal synaptic plasticity (GO:0048172)2.05727730
153cerebellar granule cell differentiation (GO:0021707)2.04826888
154cell-cell adhesion (GO:0098609)2.03329675
155potassium ion import (GO:0010107)2.03203663
156camera-type eye morphogenesis (GO:0048593)2.03067886
157cell-cell adhesion via plasma-membrane adhesion molecules (GO:0098742)2.02745867
158L-amino acid import (GO:0043092)2.00661163
159synapse organization (GO:0050808)2.00522034
160cellular ketone body metabolic process (GO:0046950)1.98965380
161iron coordination entity transport (GO:1901678)1.98254862
162urinary tract smooth muscle contraction (GO:0014848)1.98152561
163positive regulation of potassium ion transport (GO:0043268)1.96916141
164positive regulation of protein kinase C signaling (GO:0090037)1.96804924
165embryonic heart tube development (GO:0035050)1.96168904
166phospholipid translocation (GO:0045332)1.93886784
167lipid translocation (GO:0034204)1.93886784
168response to redox state (GO:0051775)1.93792990
169adhesion of symbiont to host (GO:0044406)1.92323469
170nitric oxide mediated signal transduction (GO:0007263)1.91951638

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.86356981
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.62863702
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39236446
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23912125
5SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19078414
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.16055204
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.15568589
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.12888639
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12554312
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12002515
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12002515
12JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09295922
13EZH2_22144423_ChIP-Seq_EOC_Human2.04840252
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.96869714
15RNF2_27304074_Chip-Seq_ESCs_Mouse1.92640140
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.91752663
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.91194445
18* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91158425
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.89918389
20PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.88116330
21CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86049297
22* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.83491077
23DROSHA_22980978_ChIP-Seq_HELA_Human1.82633311
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.76829210
25AR_21572438_ChIP-Seq_LNCaP_Human1.76202057
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.68034792
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.67587097
28TAF15_26573619_Chip-Seq_HEK293_Human1.65417217
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.65208304
30* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65056473
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.62100674
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.56424353
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52443396
34IGF1R_20145208_ChIP-Seq_DFB_Human1.52087701
35* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50669778
36* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.50252085
37BMI1_23680149_ChIP-Seq_NPCS_Mouse1.49797910
38* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.47499255
39* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47238444
40* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46326029
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.45127969
42TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.44693159
43* AHR_22903824_ChIP-Seq_MCF-7_Human1.43753302
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43106598
45* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40427234
46* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39791565
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.39604098
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39010220
49POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38017871
50CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37939383
51* SMAD4_21799915_ChIP-Seq_A2780_Human1.37437584
52* P300_19829295_ChIP-Seq_ESCs_Human1.34161488
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.33769305
54* ARNT_22903824_ChIP-Seq_MCF-7_Human1.32317827
55* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30666139
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.30417115
57STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.28721313
58TP53_18474530_ChIP-ChIP_U2OS_Human1.26365666
59TRIM28_21343339_ChIP-Seq_HEK293_Human1.26353776
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.26099711
61EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.25223155
62* RING1B_27294783_Chip-Seq_ESCs_Mouse1.24110082
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.21553305
64DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20948288
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19845571
66TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19426151
67POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19426151
68CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19336239
69EP300_21415370_ChIP-Seq_HL-1_Mouse1.18914912
70REST_21632747_ChIP-Seq_MESCs_Mouse1.18878224
71EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18856717
72VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.18810529
73NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18304466
74* RING1B_27294783_Chip-Seq_NPCs_Mouse1.17618736
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16467976
76SMAD_19615063_ChIP-ChIP_OVARY_Human1.16141460
77* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15472363
78ZFP281_27345836_Chip-Seq_ESCs_Mouse1.12895844
79STAT3_23295773_ChIP-Seq_U87_Human1.12655378
80NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12298837
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10749899
82TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09832590
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09407169
84AR_25329375_ChIP-Seq_VCAP_Human1.08467980
85* SOX2_21211035_ChIP-Seq_LN229_Gbm1.07049502
86TP53_16413492_ChIP-PET_HCT116_Human1.07027803
87ER_23166858_ChIP-Seq_MCF-7_Human1.06610549
88SMAD3_21741376_ChIP-Seq_HESCs_Human1.06101633
89KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05980920
90KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05980920
91KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05980920
92RNF2_27304074_Chip-Seq_NSC_Mouse1.05692177
93* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.04929250
94* RARB_27405468_Chip-Seq_BRAIN_Mouse1.04412389
95ZNF274_21170338_ChIP-Seq_K562_Hela1.04345844
96CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.04336385
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03562992
98SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.03506049
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02447065
100ISL1_27105846_Chip-Seq_CPCs_Mouse1.01694610
101* AR_19668381_ChIP-Seq_PC3_Human1.01662988
102SMAD4_21741376_ChIP-Seq_HESCs_Human1.01139544
103CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.00396344
104TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.00357336
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.99548216
106ESR1_20079471_ChIP-ChIP_T-47D_Human0.99545791
107TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98952119
108* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97172527
109* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97172527
110LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96547860
111* TCF4_23295773_ChIP-Seq_U87_Human0.95970159
112* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95925648
113FUS_26573619_Chip-Seq_HEK293_Human0.95689556
114NANOG_18555785_Chip-Seq_ESCs_Mouse0.94809572
115MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94190997
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.93511215
117SMAD4_21741376_ChIP-Seq_EPCs_Human0.93506464
118YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92274632
119FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.91701201
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90833659
121RUNX2_22187159_ChIP-Seq_PCA_Human0.90438643
122FOXA2_19822575_ChIP-Seq_HepG2_Human0.90164774
123BCAT_22108803_ChIP-Seq_LS180_Human0.89298195
124OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88722131
125BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87901282

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005551_abnormal_eye_electrophysiolog3.82958111
2MP0001346_abnormal_lacrimal_gland3.43420978
3MP0004859_abnormal_synaptic_plasticity3.14389798
4MP0005503_abnormal_tendon_morphology2.98259637
5MP0002090_abnormal_vision2.85264003
6MP0006072_abnormal_retinal_apoptosis2.67999356
7MP0005248_abnormal_Harderian_gland2.55908590
8MP0004782_abnormal_surfactant_physiolog2.49833387
9MP0002254_reproductive_system_inflammat2.27146620
10MP0001984_abnormal_olfaction2.26517378
11MP0008438_abnormal_cutaneous_collagen2.14681189
12MP0000569_abnormal_digit_pigmentation2.09182499
13MP0005253_abnormal_eye_physiology2.06119917
14MP0005195_abnormal_posterior_eye1.93252510
15MP0004270_analgesia1.91522575
16MP0002822_catalepsy1.90661993
17MP0001502_abnormal_circadian_rhythm1.90144632
18MP0003950_abnormal_plasma_membrane1.87820153
19MP0000778_abnormal_nervous_system1.84311830
20MP0001486_abnormal_startle_reflex1.83964540
21MP0005275_abnormal_skin_tensile1.80520947
22MP0000920_abnormal_myelination1.68012133
23MP0000566_synostosis1.67358295
24MP0004885_abnormal_endolymph1.65424051
25MP0005187_abnormal_penis_morphology1.63590471
26MP0008789_abnormal_olfactory_epithelium1.60374710
27MP0000534_abnormal_ureter_morphology1.56702708
28MP0010368_abnormal_lymphatic_system1.56120498
29MP0002184_abnormal_innervation1.54534265
30MP0004742_abnormal_vestibular_system1.53870490
31MP0002249_abnormal_larynx_morphology1.50617649
32MP0005409_darkened_coat_color1.48685869
33MP0003115_abnormal_respiratory_system1.46712591
34MP0005365_abnormal_bile_salt1.46474433
35MP0000428_abnormal_craniofacial_morphol1.46281210
36MP0002734_abnormal_mechanical_nocicepti1.43657657
37MP0003880_abnormal_central_pattern1.41163757
38MP0002272_abnormal_nervous_system1.40967883
39MP0003938_abnormal_ear_development1.39841567
40MP0000049_abnormal_middle_ear1.38677959
41MP0000631_abnormal_neuroendocrine_gland1.36880332
42MP0004134_abnormal_chest_morphology1.36647454
43MP0004233_abnormal_muscle_weight1.36361407
44MP0001958_emphysema1.36112466
45MP0000733_abnormal_muscle_development1.35474710
46MP0005377_hearing/vestibular/ear_phenot1.35397435
47MP0003878_abnormal_ear_physiology1.35397435
48MP0003136_yellow_coat_color1.35323276
49MP0008875_abnormal_xenobiotic_pharmacok1.35144136
50MP0005394_taste/olfaction_phenotype1.35055955
51MP0005499_abnormal_olfactory_system1.35055955
52MP0003634_abnormal_glial_cell1.34685158
53MP0002932_abnormal_joint_morphology1.32548892
54MP0008775_abnormal_heart_ventricle1.32299672
55MP0005623_abnormal_meninges_morphology1.31048711
56MP0000955_abnormal_spinal_cord1.30615969
57MP0000462_abnormal_digestive_system1.29563312
58MP0003755_abnormal_palate_morphology1.29367344
59MP0004272_abnormal_basement_membrane1.27868948
60MP0001324_abnormal_eye_pigmentation1.27856997
61MP0002229_neurodegeneration1.27149317
62MP0002752_abnormal_somatic_nervous1.26436901
63MP0005360_urolithiasis1.25546201
64MP0002116_abnormal_craniofacial_bone1.23727846
65MP0000579_abnormal_nail_morphology1.23339311
66MP0001270_distended_abdomen1.22744456
67MP0010030_abnormal_orbit_morphology1.22368787
68MP0009384_cardiac_valve_regurgitation1.18312573
69MP0004084_abnormal_cardiac_muscle1.18256918
70MP0003868_abnormal_feces_composition1.17667366
71MP0002882_abnormal_neuron_morphology1.17457601
72MP0002638_abnormal_pupillary_reflex1.16432213
73MP0005085_abnormal_gallbladder_physiolo1.15800336
74MP0001188_hyperpigmentation1.15597363
75MP0002139_abnormal_hepatobiliary_system1.13975203
76MP0002877_abnormal_melanocyte_morpholog1.13857476
77MP0000026_abnormal_inner_ear1.13814453
78MP0003119_abnormal_digestive_system1.13548925
79MP0004036_abnormal_muscle_relaxation1.13422714
80MP0002697_abnormal_eye_size1.13223673
81MP0003690_abnormal_glial_cell1.12716158
82MP0003935_abnormal_craniofacial_develop1.12108093
83MP0002735_abnormal_chemical_nociception1.11493039
84MP0000537_abnormal_urethra_morphology1.11258630
85MP0002009_preneoplasia1.11018114
86MP0003635_abnormal_synaptic_transmissio1.10262644
87MP0004811_abnormal_neuron_physiology1.10199883
88MP0003861_abnormal_nervous_system1.10101328
89MP0002896_abnormal_bone_mineralization1.09330283
90MP0005508_abnormal_skeleton_morphology1.08976597
91MP0001286_abnormal_eye_development1.08704597
92MP0005423_abnormal_somatic_nervous1.07644065
93MP0004145_abnormal_muscle_electrophysio1.07447333
94MP0001879_abnormal_lymphatic_vessel1.07180439
95MP0002152_abnormal_brain_morphology1.06408821
96MP0003122_maternal_imprinting1.06352614
97MP0003942_abnormal_urinary_system1.06292029
98MP0004133_heterotaxia1.05441748
99MP0002751_abnormal_autonomic_nervous1.01669224
100MP0005391_vision/eye_phenotype1.01268844
101MP0010678_abnormal_skin_adnexa1.00838302
102MP0002064_seizures1.00406830
103MP0002067_abnormal_sensory_capabilities1.00174778
104MP0000383_abnormal_hair_follicle0.99977360
105MP0000432_abnormal_head_morphology0.99967943
106MP0003890_abnormal_embryonic-extraembry0.99673293
107MP0005595_abnormal_vascular_smooth0.99320582
108MP0002133_abnormal_respiratory_system0.99312038
109MP0005388_respiratory_system_phenotype0.99312038
110MP0009780_abnormal_chondrocyte_physiolo0.99250120
111MP0001501_abnormal_sleep_pattern0.98861811
112MP0010234_abnormal_vibrissa_follicle0.98396677
113MP0001666_abnormal_nutrient_absorption0.98383278
114MP0001177_atelectasis0.96374925
115MP0008569_lethality_at_weaning0.94475804
116MP0003787_abnormal_imprinting0.93553024
117MP0003045_fibrosis0.93509874
118MP0009053_abnormal_anal_canal0.93067976
119MP0005167_abnormal_blood-brain_barrier0.91757380
120MP0004085_abnormal_heartbeat0.91729713
121MP0005197_abnormal_uvea_morphology0.91640603
122MP0001963_abnormal_hearing_physiology0.91224076
123MP0003252_abnormal_bile_duct0.90672213
124MP0005645_abnormal_hypothalamus_physiol0.89676265
125MP0004858_abnormal_nervous_system0.89346998
126MP0009046_muscle_twitch0.89246894
127MP0003011_delayed_dark_adaptation0.89098147
128MP0002114_abnormal_axial_skeleton0.87964790
129MP0003632_abnormal_nervous_system0.87086734
130MP0002063_abnormal_learning/memory/cond0.86053711
131MP0002081_perinatal_lethality0.85976345
132MP0001299_abnormal_eye_distance/0.84772087
133MP0005171_absent_coat_pigmentation0.84532723
134MP0002938_white_spotting0.83282482
135MP0003937_abnormal_limbs/digits/tail_de0.82730187
136MP0002233_abnormal_nose_morphology0.82037562
137MP0001485_abnormal_pinna_reflex0.81697972
138MP0009250_abnormal_appendicular_skeleto0.81566970
139MP0002108_abnormal_muscle_morphology0.80371055
140MP0003385_abnormal_body_wall0.79965907
141MP0009745_abnormal_behavioral_response0.75341456
142MP0002557_abnormal_social/conspecific_i0.74980070
143MP0000762_abnormal_tongue_morphology0.74943422
144MP0009697_abnormal_copulation0.74922202
145MP0003137_abnormal_impulse_conducting0.74502194
146MP0003329_amyloid_beta_deposits0.72815690
147MP0002572_abnormal_emotion/affect_behav0.71576826
148MP0010329_abnormal_lipoprotein_level0.70995379

Predicted human phenotypes

RankGene SetZ-score
1Congenital stationary night blindness (HP:0007642)7.37910637
2Central scotoma (HP:0000603)5.84038302
3Abnormality of macular pigmentation (HP:0008002)5.74083417
4Septo-optic dysplasia (HP:0100842)3.80658755
5Scotoma (HP:0000575)3.78516150
6Decreased central vision (HP:0007663)3.67998058
7Neurofibrillary tangles (HP:0002185)3.63849392
8Cone-rod dystrophy (HP:0000548)2.99977708
9Keratoconus (HP:0000563)2.83682677
10Increased corneal curvature (HP:0100692)2.83682677
11Action tremor (HP:0002345)2.79585319
12Aortic dissection (HP:0002647)2.79351655
13Short 4th metacarpal (HP:0010044)2.75667933
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75667933
15Severe visual impairment (HP:0001141)2.70291785
16Bony spicule pigmentary retinopathy (HP:0007737)2.69272968
17Megalencephaly (HP:0001355)2.68717159
18Abnormality of the ischium (HP:0003174)2.63933400
19Neonatal short-limb short stature (HP:0008921)2.63045902
20Abnormality of the corticospinal tract (HP:0002492)2.62054039
21Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59032277
22Degeneration of the lateral corticospinal tracts (HP:0002314)2.59032277
23Insidious onset (HP:0003587)2.53563729
24Termporal pattern (HP:0011008)2.53563729
25Deep venous thrombosis (HP:0002625)2.52864704
26Congenital sensorineural hearing impairment (HP:0008527)2.52739007
27Lip pit (HP:0100267)2.52334157
28Cerebral inclusion bodies (HP:0100314)2.51543748
29Epileptic encephalopathy (HP:0200134)2.46926034
30Atrophic scars (HP:0001075)2.41563462
31Supranuclear gaze palsy (HP:0000605)2.36136778
32Abolished electroretinogram (ERG) (HP:0000550)2.35352058
33Overgrowth (HP:0001548)2.35074665
34Abnormal rod and cone electroretinograms (HP:0008323)2.32790995
35Dyschromatopsia (HP:0007641)2.31252202
36Absent septum pellucidum (HP:0001331)2.30926638
37Pheochromocytoma (HP:0002666)2.28866635
38Cutaneous syndactyly (HP:0012725)2.27460940
39Bronchomalacia (HP:0002780)2.26996681
40Focal motor seizures (HP:0011153)2.24441077
41Pigmentary retinal degeneration (HP:0001146)2.24147535
42Anteriorly placed anus (HP:0001545)2.23791476
43Shallow orbits (HP:0000586)2.22426318
44Abnormality of the 4th metacarpal (HP:0010012)2.21966281
45Arterial tortuosity (HP:0005116)2.21870355
46Mitral valve prolapse (HP:0001634)2.20672706
47Agitation (HP:0000713)2.20286794
48Chorioretinal atrophy (HP:0000533)2.19099610
49Turricephaly (HP:0000262)2.13960436
50Midline defect of the nose (HP:0004122)2.13590429
51Bell-shaped thorax (HP:0001591)2.13058278
52Abnormality of the distal phalanx of the thumb (HP:0009617)2.13051505
53Hypoplasia of the iris (HP:0007676)2.09427414
54High anterior hairline (HP:0009890)2.08993302
55Wide anterior fontanel (HP:0000260)2.07721079
56Premature rupture of membranes (HP:0001788)2.07364631
57Severe Myopia (HP:0011003)2.06848617
58Shawl scrotum (HP:0000049)2.06835733
59Growth hormone deficiency (HP:0000824)2.05462724
60Optic nerve hypoplasia (HP:0000609)2.05042746
61Morphological abnormality of the middle ear (HP:0008609)2.04755748
62Scanning speech (HP:0002168)2.04556393
63Abnormality of aromatic amino acid family metabolism (HP:0004338)2.04247746
64Hepatoblastoma (HP:0002884)2.03844487
65Hypoplastic ischia (HP:0003175)2.03670904
66Bladder diverticulum (HP:0000015)2.03577735
67Intrahepatic cholestasis (HP:0001406)2.03556975
68Mild short stature (HP:0003502)2.03373396
69Onion bulb formation (HP:0003383)2.02865282
70Hemiparesis (HP:0001269)2.01301507
71Aplasia involving bones of the extremities (HP:0009825)2.00019622
72Aplasia involving bones of the upper limbs (HP:0009823)2.00019622
73Aplasia of the phalanges of the hand (HP:0009802)2.00019622
74Febrile seizures (HP:0002373)1.98518155
75Progressive cerebellar ataxia (HP:0002073)1.98110204
76Vascular tortuosity (HP:0004948)1.97330512
77Visceral angiomatosis (HP:0100761)1.96818809
78Genital tract atresia (HP:0001827)1.96110034
79Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.95511285
80Calcaneovalgus deformity (HP:0001848)1.94544036
81Vaginal atresia (HP:0000148)1.94293339
82Obstructive sleep apnea (HP:0002870)1.93401026
83Intention tremor (HP:0002080)1.90723029
84Ankle clonus (HP:0011448)1.90398899
85Myokymia (HP:0002411)1.85660593
86Macroorchidism (HP:0000053)1.84269877
87Neoplasm of the heart (HP:0100544)1.83745447
88Abnormality of the septum pellucidum (HP:0007375)1.83577446
89Esophageal varix (HP:0002040)1.82977907
90Germ cell neoplasia (HP:0100728)1.82278317
91Omphalocele (HP:0001539)1.82005944
92Soft skin (HP:0000977)1.81944958
93Infantile muscular hypotonia (HP:0008947)1.81164955
94Spastic gait (HP:0002064)1.79980212
95Prolonged QT interval (HP:0001657)1.79874850
96Abnormality of the parathyroid morphology (HP:0011766)1.79227950
97Large earlobe (HP:0009748)1.78748380
98Genetic anticipation (HP:0003743)1.78286311
99Tracheomalacia (HP:0002779)1.77647423
100Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.77635248
101Decreased lacrimation (HP:0000633)1.77582880
102Cubitus valgus (HP:0002967)1.76813896
103Cutaneous finger syndactyly (HP:0010554)1.76700751
104Flat cornea (HP:0007720)1.74608166
105Synostosis involving the elbow (HP:0003938)1.74320040
106Humeroradial synostosis (HP:0003041)1.74320040
107Atonic seizures (HP:0010819)1.73606953
108Bifid scrotum (HP:0000048)1.73509183
109Broad metatarsal (HP:0001783)1.73060361
110Bowel diverticulosis (HP:0005222)1.72796401
111Focal seizures (HP:0007359)1.72518912
112Hemangiomatosis (HP:0007461)1.72414441
113Genu recurvatum (HP:0002816)1.72292286
114Hyperextensible skin (HP:0000974)1.72060625
115EEG with generalized epileptiform discharges (HP:0011198)1.71167885
116Renovascular hypertension (HP:0100817)1.69034288
117Coronal craniosynostosis (HP:0004440)1.68978782
118Abnormality of the parietal bone (HP:0002696)1.68065100
119Absence seizures (HP:0002121)1.68000121
120Aplasia cutis congenita (HP:0001057)1.66559607
121Hammertoe (HP:0001765)1.66474101
122Missing ribs (HP:0000921)1.65924481
123Deformed tarsal bones (HP:0008119)1.64839549
124Buphthalmos (HP:0000557)1.64259838
125Hypoplasia of the fovea (HP:0007750)1.64163582
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.64163582
127Neuroendocrine neoplasm (HP:0100634)1.63978931
128Portal hypertension (HP:0001409)1.63940947
129Partial duplication of thumb phalanx (HP:0009944)1.63217472
130Dysmetria (HP:0001310)1.62617775
131Dysdiadochokinesis (HP:0002075)1.62515090
132Laryngomalacia (HP:0001601)1.62278465
133Vertebral arch anomaly (HP:0008438)1.62277302
134Abnormality of calcium-phosphate metabolism (HP:0100530)1.61775410
135Thickened helices (HP:0000391)1.61643194
136Alacrima (HP:0000522)1.60868041
137Heterotopia (HP:0002282)1.60512271
138Cholecystitis (HP:0001082)1.59653761
139Abnormal gallbladder physiology (HP:0012438)1.59653761
140Abnormality of the calcaneus (HP:0008364)1.59082009
141Hyperlipoproteinemia (HP:0010980)1.58803476
142Blue irides (HP:0000635)1.57638771
143Epileptiform EEG discharges (HP:0011182)1.57482025
144Arnold-Chiari malformation (HP:0002308)1.57417140
145Vitreoretinal degeneration (HP:0000655)1.56715268
146Facial shape deformation (HP:0011334)1.56592674
147Potter facies (HP:0002009)1.56592674
148Abnormal ciliary motility (HP:0012262)1.56247348
149Morphological abnormality of the pyramidal tract (HP:0002062)1.55947314
150Lower limb muscle weakness (HP:0007340)1.55602428
151Disproportionate tall stature (HP:0001519)1.55509863
152Drooling (HP:0002307)1.55476663
153Excessive salivation (HP:0003781)1.55476663
154Cerebral hemorrhage (HP:0001342)1.55395355
155Mitral stenosis (HP:0001718)1.54869785
156Hyperventilation (HP:0002883)1.54783167
157Urinary urgency (HP:0000012)1.54638836
158Papillary thyroid carcinoma (HP:0002895)1.54059929
159Renal hypoplasia (HP:0000089)1.53578701
160Hypoplastic nipples (HP:0002557)1.53024188
161Attenuation of retinal blood vessels (HP:0007843)1.52191937
162Truncal ataxia (HP:0002078)1.51540929
163Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.51291040
164Abnormality of the fovea (HP:0000493)1.51047116
165Protrusio acetabuli (HP:0003179)1.50725874
166Gait imbalance (HP:0002141)1.50550828
167Rhinitis (HP:0012384)1.50408735
168Broad face (HP:0000283)1.50080025
169Overriding aorta (HP:0002623)1.50060345
170Hypoplastic labia majora (HP:0000059)1.49842374
171Abnormality of dentin (HP:0010299)1.49801540
172Fragile skin (HP:0001030)1.49649851
173Abnormal respiratory motile cilium morphology (HP:0005938)1.49299223
174Abnormal respiratory epithelium morphology (HP:0012253)1.49299223
175Partial duplication of the phalanx of hand (HP:0009999)1.48862159

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA34.39922196
2INSRR3.05163046
3EPHB12.76339093
4STK392.61771589
5LATS22.50158270
6NTRK32.33503767
7PAK62.16593558
8FGFR21.97456681
9MKNK21.96194216
10SIK11.94151365
11EPHA41.91330434
12TNIK1.89094408
13ERBB31.85661044
14TIE11.82766918
15RIPK11.74051409
16NTRK11.59463841
17LATS11.54772346
18MKNK11.53800044
19SGK2231.53006673
20SGK4941.53006673
21PBK1.51871961
22TRIB31.50943544
23FRK1.49473180
24PKN11.49124733
25PKN21.48600232
26CAMK1G1.42898688
27PHKG11.36059283
28PHKG21.36059283
29BMPR21.35790102
30MARK11.35536585
31MAP3K101.35127321
32PAK31.33301004
33MAPK151.30602863
34BCR1.26983420
35STK38L1.25792436
36WNK11.25460493
37MET1.21203705
38KSR11.18866517
39ERBB21.16471285
40WNK41.14387597
41DYRK1A1.14340637
42OXSR11.12523326
43EPHB21.12220099
44PTK61.11417243
45FER1.11135655
46CASK1.09254712
47NEK61.04142191
48TYRO31.03290216
49CAMK2D1.01927122
50CSNK1A1L1.01007876
51IRAK21.00277805
52ICK0.99037746
53NTRK20.95641981
54PRPF4B0.95115649
55NUAK10.95103847
56MAP3K40.93396727
57CDK120.92658206
58MINK10.90839669
59ROCK20.89004597
60MOS0.88360527
61PRKCE0.87096897
62PRKD30.85997227
63HIPK20.85810861
64MELK0.85551853
65DAPK20.83053222
66MAPK130.82986859
67FGFR10.80355363
68GRK10.80324023
69CDK30.78965396
70DYRK1B0.77537670
71MAP3K70.77281991
72MAP2K20.74714051
73PTK20.74509035
74NEK90.74071262
75MAPK100.74042804
76CAMKK10.73838715
77MAP3K90.73716935
78MARK20.73000863
79PRKAA20.72390338
80YES10.72107397
81IRAK10.72084097
82CSNK1G20.71909095
83PINK10.71819712
84RET0.71612095
85MTOR0.71380894
86UHMK10.71155313
87STK380.67142383
88SIK20.66050362
89ROCK10.65864838
90CAMK1D0.65750535
91MAPKAPK50.65487458
92AKT30.65386670
93LMTK20.65321041
94EEF2K0.64885435
95CSNK1G30.64835442
96CDK50.64811828
97SGK20.64560300
98GSK3A0.63592246
99DDR20.63352356
100FGFR40.62479438
101BRD40.61854502
102CSNK1G10.61185766
103CAMK2A0.59967339
104PAK20.59460925
105PIK3CA0.59361043
106TAOK30.56641086
107CAMK2B0.56329661
108PDGFRB0.55816390
109PRKD10.54609372
110PRKG10.53795036
111PRKAA10.53120295
112MAPK70.53038529
113CDK180.52725540
114CAMK2G0.50434567
115PRKCZ0.49786562
116CDK150.49176150
117SGK30.48867196
118PNCK0.48620027
119MAP2K70.46898334
120MAP3K20.46478500
121PTK2B0.45588748
122PDGFRA0.45304463
123PRKCH0.45232438
124SGK10.44474528
125STK30.44313531
126NLK0.44285830
127DMPK0.44273456
128KSR20.44178333
129FGFR30.43412639
130RPS6KA20.42633827
131EPHA20.41940076
132MAP3K60.41894293
133CDK11A0.41743840
134TRPM70.41590190
135RAF10.41564135
136BMPR1B0.38606393
137PLK20.36300336
138CDC42BPA0.34789479
139TGFBR10.33008269
140CDK60.32744366

Predicted pathways (KEGG)

RankGene SetZ-score
1GABAergic synapse_Homo sapiens_hsa047272.25648529
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.16417821
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.93367310
4Nicotine addiction_Homo sapiens_hsa050331.79859207
5Morphine addiction_Homo sapiens_hsa050321.73775576
6Nitrogen metabolism_Homo sapiens_hsa009101.64785111
7Arginine biosynthesis_Homo sapiens_hsa002201.62565479
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61713310
9Wnt signaling pathway_Homo sapiens_hsa043101.59438366
10Long-term potentiation_Homo sapiens_hsa047201.57557389
11Steroid biosynthesis_Homo sapiens_hsa001001.55940657
12Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51851581
13Insulin secretion_Homo sapiens_hsa049111.50960704
14Circadian entrainment_Homo sapiens_hsa047131.49804756
15Adherens junction_Homo sapiens_hsa045201.48877946
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47207159
17Butanoate metabolism_Homo sapiens_hsa006501.45886361
18Colorectal cancer_Homo sapiens_hsa052101.45737654
19Endometrial cancer_Homo sapiens_hsa052131.45310304
20Axon guidance_Homo sapiens_hsa043601.41934551
21Synaptic vesicle cycle_Homo sapiens_hsa047211.40554735
22Bile secretion_Homo sapiens_hsa049761.40230073
23Estrogen signaling pathway_Homo sapiens_hsa049151.38772680
24Glutamatergic synapse_Homo sapiens_hsa047241.37129678
25Glioma_Homo sapiens_hsa052141.30680101
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.28431683
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.28429355
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.27408589
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.27106048
30Cholinergic synapse_Homo sapiens_hsa047251.25742155
31Phototransduction_Homo sapiens_hsa047441.25401441
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24719353
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24686744
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.23925741
35Chronic myeloid leukemia_Homo sapiens_hsa052201.23452909
36Renin secretion_Homo sapiens_hsa049241.22082069
37Choline metabolism in cancer_Homo sapiens_hsa052311.20731034
38MicroRNAs in cancer_Homo sapiens_hsa052061.19658194
39Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17460228
40Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.17439330
41Ovarian steroidogenesis_Homo sapiens_hsa049131.16383193
42Inositol phosphate metabolism_Homo sapiens_hsa005621.15702525
43Notch signaling pathway_Homo sapiens_hsa043301.15009150
44Proteoglycans in cancer_Homo sapiens_hsa052051.15002473
45Fatty acid elongation_Homo sapiens_hsa000621.12896056
46Serotonergic synapse_Homo sapiens_hsa047261.12373658
47Neurotrophin signaling pathway_Homo sapiens_hsa047221.11905303
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.11076517
49Salivary secretion_Homo sapiens_hsa049701.10039119
50Focal adhesion_Homo sapiens_hsa045101.09189859
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08660401
52Circadian rhythm_Homo sapiens_hsa047101.08503354
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07967386
54Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.06189061
55Dilated cardiomyopathy_Homo sapiens_hsa054141.05754132
56Olfactory transduction_Homo sapiens_hsa047401.05297217
57Sulfur metabolism_Homo sapiens_hsa009201.04838773
58Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01075146
59Rap1 signaling pathway_Homo sapiens_hsa040150.99733189
60Dorso-ventral axis formation_Homo sapiens_hsa043200.98982496
61Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.97069709
62Prostate cancer_Homo sapiens_hsa052150.96456087
63ABC transporters_Homo sapiens_hsa020100.96421365
64Type II diabetes mellitus_Homo sapiens_hsa049300.96268777
65Amoebiasis_Homo sapiens_hsa051460.95728625
66Pancreatic cancer_Homo sapiens_hsa052120.95582468
67Non-small cell lung cancer_Homo sapiens_hsa052230.93726090
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.93662726
69Prolactin signaling pathway_Homo sapiens_hsa049170.92054114
70Pathways in cancer_Homo sapiens_hsa052000.90890224
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90717121
72TGF-beta signaling pathway_Homo sapiens_hsa043500.90478659
73Tryptophan metabolism_Homo sapiens_hsa003800.90081510
74Dopaminergic synapse_Homo sapiens_hsa047280.87289356
75Ether lipid metabolism_Homo sapiens_hsa005650.86698406
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85494158
77Mineral absorption_Homo sapiens_hsa049780.85073631
78Melanoma_Homo sapiens_hsa052180.84644826
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.83166258
80Fatty acid metabolism_Homo sapiens_hsa012120.81694067
81Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81682347
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81477423
83Retinol metabolism_Homo sapiens_hsa008300.81409260
84Histidine metabolism_Homo sapiens_hsa003400.80021443
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79705678
86Taste transduction_Homo sapiens_hsa047420.79698251
87Pancreatic secretion_Homo sapiens_hsa049720.79381537
88mTOR signaling pathway_Homo sapiens_hsa041500.78834265
89ECM-receptor interaction_Homo sapiens_hsa045120.77792830
90Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.77723099
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76919421
92Protein digestion and absorption_Homo sapiens_hsa049740.75186782
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75127381
94VEGF signaling pathway_Homo sapiens_hsa043700.74637442
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74401554
96Small cell lung cancer_Homo sapiens_hsa052220.74069499
97MAPK signaling pathway_Homo sapiens_hsa040100.73776916
98FoxO signaling pathway_Homo sapiens_hsa040680.73271026
99Oxytocin signaling pathway_Homo sapiens_hsa049210.72616439
100cAMP signaling pathway_Homo sapiens_hsa040240.71880749
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.70415548
102Renal cell carcinoma_Homo sapiens_hsa052110.69985816
103Complement and coagulation cascades_Homo sapiens_hsa046100.69934133
104Cocaine addiction_Homo sapiens_hsa050300.68500531
105Thyroid cancer_Homo sapiens_hsa052160.67149579
106Fatty acid degradation_Homo sapiens_hsa000710.66127295
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65480886
108PPAR signaling pathway_Homo sapiens_hsa033200.65315225
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63297014
110Insulin signaling pathway_Homo sapiens_hsa049100.63025679
111Long-term depression_Homo sapiens_hsa047300.62997246
112Gastric acid secretion_Homo sapiens_hsa049710.61987486
113Gap junction_Homo sapiens_hsa045400.61781894
114Peroxisome_Homo sapiens_hsa041460.60024390
115Arginine and proline metabolism_Homo sapiens_hsa003300.59474212
116Calcium signaling pathway_Homo sapiens_hsa040200.58833654
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.58759394
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.58438616
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57552420
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57228309
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56757137
122Thyroid hormone synthesis_Homo sapiens_hsa049180.55209639
123Hedgehog signaling pathway_Homo sapiens_hsa043400.54117574
124Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54010231
125AMPK signaling pathway_Homo sapiens_hsa041520.53893111
126Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53661140
127Fat digestion and absorption_Homo sapiens_hsa049750.52423285
128Sphingolipid metabolism_Homo sapiens_hsa006000.52285765
129Basal cell carcinoma_Homo sapiens_hsa052170.51909201
130Chemical carcinogenesis_Homo sapiens_hsa052040.51187415
131Lysine degradation_Homo sapiens_hsa003100.49883486
132Ras signaling pathway_Homo sapiens_hsa040140.48676381
133Tight junction_Homo sapiens_hsa045300.47972009
134Vitamin digestion and absorption_Homo sapiens_hsa049770.47296932
135Amphetamine addiction_Homo sapiens_hsa050310.46558168
136Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46404059
137Melanogenesis_Homo sapiens_hsa049160.46115774
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45673324
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.45354999
140Hippo signaling pathway_Homo sapiens_hsa043900.45001826
141ErbB signaling pathway_Homo sapiens_hsa040120.43624801
142GnRH signaling pathway_Homo sapiens_hsa049120.40959842

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