TMSB4XP8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cytidine catabolic process (GO:0006216)8.82481274
2cytidine deamination (GO:0009972)8.82481274
3cytidine metabolic process (GO:0046087)8.82481274
4pyrimidine ribonucleoside catabolic process (GO:0046133)7.85852973
5regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450917.36584695
6sequestering of actin monomers (GO:0042989)6.99836618
7DNA deamination (GO:0045006)6.98075309
8regulation of interleukin-12 biosynthetic process (GO:0045075)5.87564622
9positive regulation of interleukin-8 secretion (GO:2000484)5.46120972
10regulation of B cell receptor signaling pathway (GO:0050855)4.71367760
11positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)4.46004699
12regulation of activation of Janus kinase activity (GO:0010533)4.42188639
13positive regulation of T cell apoptotic process (GO:0070234)4.41505995
14positive regulation of natural killer cell mediated immunity (GO:0002717)4.40090486
15positive thymic T cell selection (GO:0045059)4.39870552
16positive T cell selection (GO:0043368)4.36659745
17membrane tubulation (GO:0097320)4.25338187
18Arp2/3 complex-mediated actin nucleation (GO:0034314)4.16791802
19regulation of cellular respiration (GO:0043457)4.15266948
20pyrimidine nucleoside catabolic process (GO:0046135)4.06685120
21positive regulation of gamma-delta T cell activation (GO:0046645)4.06117487
22ribosomal small subunit assembly (GO:0000028)4.04975973
23regulation of interleukin-8 secretion (GO:2000482)4.03913895
24positive regulation of B cell differentiation (GO:0045579)4.01622921
25eosinophil chemotaxis (GO:0048245)4.01557273
26regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.98701735
27negative T cell selection (GO:0043383)3.98278875
28negative regulation of glycogen biosynthetic process (GO:0045719)3.91550749
29T cell migration (GO:0072678)3.86877722
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.81627039
31negative regulation of viral genome replication (GO:0045071)3.80702860
32negative regulation of T cell apoptotic process (GO:0070233)3.79720059
33actin nucleation (GO:0045010)3.79187409
34regulation of natural killer cell mediated immunity (GO:0002715)3.77450008
35regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.77450008
36negative regulation of cardiac muscle hypertrophy (GO:0010614)3.77146049
37regulation of regulatory T cell differentiation (GO:0045589)3.69910535
38eosinophil migration (GO:0072677)3.68763192
39positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.68544528
40regulation of energy homeostasis (GO:2000505)3.53788319
41cytolysis (GO:0019835)3.53038971
42negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.52315966
43thymic T cell selection (GO:0045061)3.52068642
44tolerance induction (GO:0002507)3.51020190
45positive regulation of monocyte chemotaxis (GO:0090026)3.50749755
46regulation of gamma-delta T cell differentiation (GO:0045586)3.48867825
47negative regulation of muscle hypertrophy (GO:0014741)3.48690348
48cellular response to interleukin-15 (GO:0071350)3.46817542
49positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.38745675
50protein neddylation (GO:0045116)3.36110575
51negative regulation by host of viral transcription (GO:0043922)3.36031541
52positive regulation of T cell chemotaxis (GO:0010820)3.35836288
53regulation of T cell chemotaxis (GO:0010819)3.35836288
54ubiquinone biosynthetic process (GO:0006744)3.34766464
55negative regulation of oxidoreductase activity (GO:0051354)3.32683501
56macrophage chemotaxis (GO:0048246)3.28367103
57regulation of leukocyte mediated cytotoxicity (GO:0001910)3.27764749
58positive regulation of calcium-mediated signaling (GO:0050850)3.27219979
59positive regulation of cell killing (GO:0031343)3.25978133
60ribosomal small subunit biogenesis (GO:0042274)3.24804678
61negative thymic T cell selection (GO:0045060)3.22467199
62regulation of lymphocyte chemotaxis (GO:1901623)3.19244860
63chemokine-mediated signaling pathway (GO:0070098)3.19185395
64positive regulation of lymphocyte apoptotic process (GO:0070230)3.18670833
65regulation of T cell receptor signaling pathway (GO:0050856)3.18653024
66T cell selection (GO:0045058)3.17600269
67negative regulation of glycogen metabolic process (GO:0070874)3.15485660
68regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.13294299
69regulation of B cell differentiation (GO:0045577)3.10424847
70regulation of T cell apoptotic process (GO:0070232)3.09693496
71regulation of chronic inflammatory response (GO:0002676)3.09681781
72T cell receptor signaling pathway (GO:0050852)3.08943343
73viral transcription (GO:0019083)3.07881706
74T cell costimulation (GO:0031295)3.07836791
75lymph node development (GO:0048535)3.04765748
76lymphocyte costimulation (GO:0031294)3.04569761
77ubiquinone metabolic process (GO:0006743)3.00511011
78protein heterotetramerization (GO:0051290)3.00316106
79regulation of cell killing (GO:0031341)2.97180191
80positive regulation of lymphocyte migration (GO:2000403)2.96281930
81negative regulation of monooxygenase activity (GO:0032769)2.95744794
82forebrain morphogenesis (GO:0048853)2.94942871
83negative regulation of calcium ion transport into cytosol (GO:0010523)2.94286171
84regulation of T cell tolerance induction (GO:0002664)2.93090475
85mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.91581232
86translational termination (GO:0006415)2.87577430
87response to pheromone (GO:0019236)2.87573054
88positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86812317
89positive regulation of T cell mediated cytotoxicity (GO:0001916)2.85273488
90pyrimidine-containing compound catabolic process (GO:0072529)2.83931902
91regulation of gamma-delta T cell activation (GO:0046643)2.83626543
92regulation of oxidative stress-induced neuron death (GO:1903203)2.83520083
93quinone biosynthetic process (GO:1901663)2.83443533
94positive regulation of tolerance induction (GO:0002645)2.80372605
95natural killer cell activation (GO:0030101)2.79398452
96mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75762309
97ATP synthesis coupled proton transport (GO:0015986)2.75714533
98energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75714533
99regulation of chemokine-mediated signaling pathway (GO:0070099)2.75710521
100negative regulation of mast cell activation (GO:0033004)2.75677309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.40228383
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.72144405
3EZH2_22144423_ChIP-Seq_EOC_Human3.96393670
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.79457378
5IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.74821103
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.15739308
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.75946954
8RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.44546884
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40847801
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.35039741
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.33217442
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.31136570
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.29932360
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.27899264
15IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10801046
16ZNF274_21170338_ChIP-Seq_K562_Hela1.96050555
17GABP_17652178_ChIP-ChIP_JURKAT_Human1.89315660
18VDR_22108803_ChIP-Seq_LS180_Human1.86717141
19GATA3_27048872_Chip-Seq_THYMUS_Human1.80327706
20LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.79775894
21RUNX_20019798_ChIP-Seq_JUKART_Human1.79555662
22MYB_26560356_Chip-Seq_TH2_Human1.76112168
23STAT4_19710469_ChIP-ChIP_TH1__Mouse1.75524470
24HTT_18923047_ChIP-ChIP_STHdh_Human1.72458377
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.59986444
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.53633191
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51147629
28RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.46513636
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.45792468
30UTX_26944678_Chip-Seq_JUKART_Human1.45446815
31PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.43107288
32CTBP1_25329375_ChIP-Seq_LNCAP_Human1.42063650
33EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.41211300
34NANOG_20526341_ChIP-Seq_ESCs_Human1.40185725
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.39054332
36TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.35789100
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.33507992
38GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.31297589
39MYB_26560356_Chip-Seq_TH1_Human1.30345192
40MAF_26560356_Chip-Seq_TH2_Human1.29103114
41ER_23166858_ChIP-Seq_MCF-7_Human1.26435981
42BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.26434346
43BCL6_27268052_Chip-Seq_Bcells_Human1.25762279
44STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22568318
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.22027720
46TP53_22573176_ChIP-Seq_HFKS_Human1.21129272
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.20879651
48EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19545050
49GATA3_26560356_Chip-Seq_TH2_Human1.17733185
50AUTS2_25519132_ChIP-Seq_293T-REX_Human1.16953767
51NCOR_22424771_ChIP-Seq_293T_Human1.14893790
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.14827734
53CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.13056411
54TAF2_19829295_ChIP-Seq_ESCs_Human1.12350066
55AR_20517297_ChIP-Seq_VCAP_Human1.12208223
56DROSHA_22980978_ChIP-Seq_HELA_Human1.10759436
57PCGF2_27294783_Chip-Seq_NPCs_Mouse1.10635965
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.09290809
59ERG_20517297_ChIP-Seq_VCAP_Human1.08148498
60SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07890074
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07406478
62EED_16625203_ChIP-ChIP_MESCs_Mouse1.06043428
63EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.05862042
64SA1_27219007_Chip-Seq_Bcells_Human1.05562112
65RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human1.05263117
66ETV2_25802403_ChIP-Seq_MESCs_Mouse1.05235968
67FLI1_27457419_Chip-Seq_LIVER_Mouse1.05189482
68ELF1_20517297_ChIP-Seq_JURKAT_Human1.04783227
69EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02685166
70SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02247554
71P300_27268052_Chip-Seq_Bcells_Human1.02187173
72SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01886219
73EZH2_27294783_Chip-Seq_ESCs_Mouse1.00389278
74JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00276045
75SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.99853284
76TDRD3_21172665_ChIP-Seq_MCF-7_Human0.99657693
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98174201
78PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98173087
79CBX2_27304074_Chip-Seq_ESCs_Mouse0.97462592
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97288046
81EST1_17652178_ChIP-ChIP_JURKAT_Human0.97054198
82VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.96998739
83CBP_20019798_ChIP-Seq_JUKART_Human0.96960842
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.96960842
85VDR_23849224_ChIP-Seq_CD4+_Human0.96476362
86FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.95527099
87CTCF_20526341_ChIP-Seq_ESCs_Human0.95211134
88CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.94802497
89EZH2_27304074_Chip-Seq_ESCs_Mouse0.94754270
90GBX2_23144817_ChIP-Seq_PC3_Human0.94011347
91FOXA1_27270436_Chip-Seq_PROSTATE_Human0.93959179
92FOXA1_25329375_ChIP-Seq_VCAP_Human0.93959179
93RAC3_21632823_ChIP-Seq_H3396_Human0.93870492
94MYC_19829295_ChIP-Seq_ESCs_Human0.93514973
95BCAT_22108803_ChIP-Seq_LS180_Human0.92887868
96NFE2_27457419_Chip-Seq_LIVER_Mouse0.92448341
97MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.90708022
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89994549
99PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89659136
100PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.88081690

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006054_spinal_hemorrhage5.75422825
2MP0005671_abnormal_response_to5.11974004
3MP0009785_altered_susceptibility_to3.58062011
4MP0002653_abnormal_ependyma_morphology3.43893383
5MP0002837_dystrophic_cardiac_calcinosis3.42399473
6MP0009333_abnormal_splenocyte_physiolog2.93274527
7MP0005623_abnormal_meninges_morphology2.53687198
8MP0004145_abnormal_muscle_electrophysio2.45897057
9MP0003763_abnormal_thymus_physiology2.38277139
10MP0001800_abnormal_humoral_immune2.30572115
11MP0009379_abnormal_foot_pigmentation2.26720492
12MP0003866_abnormal_defecation2.12356764
13MP0005000_abnormal_immune_tolerance2.10236453
14MP0003279_aneurysm2.02490960
15MP0002723_abnormal_immune_serum1.96821761
16MP0005025_abnormal_response_to1.91756948
17MP0004084_abnormal_cardiac_muscle1.86043863
18MP0001873_stomach_inflammation1.83376182
19MP0010155_abnormal_intestine_physiology1.80374971
20MP0003646_muscle_fatigue1.77756832
21MP0006082_CNS_inflammation1.76567728
22MP0002420_abnormal_adaptive_immunity1.72236647
23MP0001835_abnormal_antigen_presentation1.66713901
24MP0002102_abnormal_ear_morphology1.65319141
25MP0001819_abnormal_immune_cell1.64038792
26MP0002163_abnormal_gland_morphology1.59302734
27MP0001986_abnormal_taste_sensitivity1.58771421
28MP0004147_increased_porphyrin_level1.56967855
29MP0008872_abnormal_physiological_respon1.56139857
30MP0002933_joint_inflammation1.53824170
31MP0002452_abnormal_antigen_presenting1.48918533
32MP0002148_abnormal_hypersensitivity_rea1.48894640
33MP0004036_abnormal_muscle_relaxation1.48549866
34MP0002638_abnormal_pupillary_reflex1.44577518
35MP0000685_abnormal_immune_system1.43682235
36MP0002405_respiratory_system_inflammati1.41667729
37MP0001845_abnormal_inflammatory_respons1.40907920
38MP0005377_hearing/vestibular/ear_phenot1.32690012
39MP0003878_abnormal_ear_physiology1.32690012
40MP0000716_abnormal_immune_system1.32592288
41MP0005645_abnormal_hypothalamus_physiol1.31162240
42MP0001919_abnormal_reproductive_system1.31003631
43MP0005387_immune_system_phenotype1.30234045
44MP0001790_abnormal_immune_system1.30234045
45MP0004130_abnormal_muscle_cell1.27284361
46MP0002693_abnormal_pancreas_physiology1.27212921
47MP0001905_abnormal_dopamine_level1.27189326
48MP0001485_abnormal_pinna_reflex1.25242018
49MP0000703_abnormal_thymus_morphology1.21432310
50MP0002398_abnormal_bone_marrow1.19950148
51MP0002722_abnormal_immune_system1.19883819
52MP0003195_calcinosis1.17858207
53MP0002419_abnormal_innate_immunity1.16369501
54MP0004742_abnormal_vestibular_system1.15280920
55MP0009765_abnormal_xenobiotic_induced1.14896352
56MP0001348_abnormal_lacrimal_gland1.12695161
57MP0001968_abnormal_touch/_nociception1.09719404
58MP0000689_abnormal_spleen_morphology1.08712197
59MP0005389_reproductive_system_phenotype1.06259001
60MP0008789_abnormal_olfactory_epithelium1.04714984
61MP0003880_abnormal_central_pattern1.01906147
62MP0005551_abnormal_eye_electrophysiolog1.01358039
63MP0003283_abnormal_digestive_organ0.96262282
64MP0010386_abnormal_urinary_bladder0.94864976
65MP0002429_abnormal_blood_cell0.94082285
66MP0002733_abnormal_thermal_nociception0.92304501
67MP0009763_increased_sensitivity_to0.92108821
68MP0002166_altered_tumor_susceptibility0.90563954
69MP0008469_abnormal_protein_level0.89036635
70MP0004885_abnormal_endolymph0.87939840
71MP0006292_abnormal_olfactory_placode0.87620236
72MP0006276_abnormal_autonomic_nervous0.84382859
73MP0003448_altered_tumor_morphology0.83908154
74MP0000678_abnormal_parathyroid_gland0.83648351
75MP0001542_abnormal_bone_strength0.83632612
76MP0002277_abnormal_respiratory_mucosa0.82641477
77MP0009764_decreased_sensitivity_to0.82378434
78MP0001764_abnormal_homeostasis0.82319761
79MP0002095_abnormal_skin_pigmentation0.80915308
80MP0002736_abnormal_nociception_after0.79683449
81MP0003436_decreased_susceptibility_to0.79214716
82MP0002876_abnormal_thyroid_physiology0.77435194
83MP0002234_abnormal_pharynx_morphology0.76359206
84MP0003938_abnormal_ear_development0.76000060
85MP0009745_abnormal_behavioral_response0.74751665
86MP0004215_abnormal_myocardial_fiber0.74701328
87MP0001661_extended_life_span0.74437554
88MP0001970_abnormal_pain_threshold0.71844392
89MP0002160_abnormal_reproductive_system0.70120158
90MP0005310_abnormal_salivary_gland0.68442616
91MP0001984_abnormal_olfaction0.67883607
92MP0008877_abnormal_DNA_methylation0.66962622
93MP0003011_delayed_dark_adaptation0.65780018
94MP0005166_decreased_susceptibility_to0.65686026
95MP0005448_abnormal_energy_balance0.64622340
96MP0005410_abnormal_fertilization0.64430749
97MP0005379_endocrine/exocrine_gland_phen0.63923627
98MP0002006_tumorigenesis0.62825889
99MP0001853_heart_inflammation0.62743511
100MP0005394_taste/olfaction_phenotype0.62420843

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)5.00941226
2Chronic hepatic failure (HP:0100626)4.87328177
3Abnormality of T cell number (HP:0011839)4.49338570
4IgG deficiency (HP:0004315)4.41937876
5Acute necrotizing encephalopathy (HP:0006965)4.40832795
6T lymphocytopenia (HP:0005403)4.30930896
7Abnormality of B cell number (HP:0010975)4.21964462
8Mitochondrial inheritance (HP:0001427)4.05738227
9Abnormal mitochondria in muscle tissue (HP:0008316)3.87757905
10Hypoproteinemia (HP:0003075)3.83683013
11Elevated erythrocyte sedimentation rate (HP:0003565)3.76651162
12Progressive macrocephaly (HP:0004481)3.69446223
13Autoimmune hemolytic anemia (HP:0001890)3.68591675
14Abnormal number of erythroid precursors (HP:0012131)3.67990775
15Increased IgM level (HP:0003496)3.62095340
16Acute encephalopathy (HP:0006846)3.50961734
17Hepatocellular necrosis (HP:0001404)3.50809389
18Abnormality of cells of the erythroid lineage (HP:0012130)3.50786407
19Severe combined immunodeficiency (HP:0004430)3.48438243
20Stomatitis (HP:0010280)3.44707048
21Congenital stationary night blindness (HP:0007642)3.42029782
22Absent rod-and cone-mediated responses on ERG (HP:0007688)3.35342715
23Chronic diarrhea (HP:0002028)3.24688728
24Thyroiditis (HP:0100646)3.22934575
25B lymphocytopenia (HP:0010976)3.18214124
26Increased CSF lactate (HP:0002490)3.09225186
27Abnormality of the prostate (HP:0008775)3.00486509
28True hermaphroditism (HP:0010459)2.98553478
29Severe visual impairment (HP:0001141)2.96822569
30Hepatic necrosis (HP:0002605)2.89021878
31Pancreatic fibrosis (HP:0100732)2.80771782
32Pancreatic cysts (HP:0001737)2.76905277
33Cerebral edema (HP:0002181)2.75815001
34Lymphopenia (HP:0001888)2.74132203
35Absent/shortened dynein arms (HP:0200106)2.72835550
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.72835550
37Abnormal rod and cone electroretinograms (HP:0008323)2.71980648
38Increased hepatocellular lipid droplets (HP:0006565)2.68973156
39Abnormality of cells of the lymphoid lineage (HP:0012140)2.68901988
40Combined immunodeficiency (HP:0005387)2.68705389
41Optic disc pallor (HP:0000543)2.66435306
42Abnormality of eosinophils (HP:0001879)2.65227039
43Mutism (HP:0002300)2.64170903
44Increased intramyocellular lipid droplets (HP:0012240)2.61428105
453-Methylglutaconic aciduria (HP:0003535)2.60575010
46Hypoalbuminemia (HP:0003073)2.59109029
47Abnormal albumin level (HP:0012116)2.59109029
48Abnormality of T cells (HP:0002843)2.51574439
49Renal Fanconi syndrome (HP:0001994)2.44162310
50Gastrointestinal infarctions (HP:0005244)2.38635224
51Premature ovarian failure (HP:0008209)2.32469628
52Oral leukoplakia (HP:0002745)2.27441754
53Abnormality of macrophages (HP:0004311)2.25848722
54Lipid accumulation in hepatocytes (HP:0006561)2.22739049
55Hemiplegia (HP:0002301)2.21109566
56Ureteral stenosis (HP:0000071)2.13843726
57Hypoplasia of the thymus (HP:0000778)2.12857783
58Attenuation of retinal blood vessels (HP:0007843)2.11846357
59Increased muscle lipid content (HP:0009058)2.09940172
60Autoimmune thrombocytopenia (HP:0001973)2.08289800
61Leukocytosis (HP:0001974)2.06877024
62Chronic obstructive pulmonary disease (HP:0006510)2.06146662
63Obstructive lung disease (HP:0006536)2.06146662
64Gangrene (HP:0100758)2.05607802
65Pancytopenia (HP:0001876)2.05136688
66Eosinophilia (HP:0001880)2.04038338
67Abolished electroretinogram (ERG) (HP:0000550)2.03412290
68Increased serum lactate (HP:0002151)2.03275784
69Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.03023712
70Cystic liver disease (HP:0006706)1.98648874
71Leukodystrophy (HP:0002415)1.97714143
72Stomach cancer (HP:0012126)1.97693017
73Meningitis (HP:0001287)1.95239406
74Recurrent bronchitis (HP:0002837)1.94684117
75Agammaglobulinemia (HP:0004432)1.94659057
76Exertional dyspnea (HP:0002875)1.94402395
77Lethargy (HP:0001254)1.94312749
78Decreased central vision (HP:0007663)1.94305565
79Anomalous pulmonary venous return (HP:0010772)1.93452159
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93071914
81Abnormal respiratory motile cilium morphology (HP:0005938)1.92847325
82Abnormal respiratory epithelium morphology (HP:0012253)1.92847325
83Abnormal ciliary motility (HP:0012262)1.92688014
84Generalized aminoaciduria (HP:0002909)1.88844034
85IgM deficiency (HP:0002850)1.88308210
86Ureteral obstruction (HP:0006000)1.88048332
87Constricted visual fields (HP:0001133)1.87330029
88Progressive inability to walk (HP:0002505)1.87189926
89Aortic regurgitation (HP:0001659)1.86932761
90Chronic otitis media (HP:0000389)1.86667309
91Abnormality of binocular vision (HP:0011514)1.85870441
92Diplopia (HP:0000651)1.85870441
93Amyotrophic lateral sclerosis (HP:0007354)1.84695559
94Abnormal delayed hypersensitivity skin test (HP:0002963)1.84111088
95Abnormal respiratory motile cilium physiology (HP:0012261)1.82769427
96Molar tooth sign on MRI (HP:0002419)1.81664704
97Abnormality of midbrain morphology (HP:0002418)1.81664704
98Encephalitis (HP:0002383)1.78478908
99Bronchitis (HP:0012387)1.78243061
100Lymphoma (HP:0002665)1.77368410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PASK7.41883137
2TXK6.46326462
3KDR4.73206991
4CAMKK13.67358493
5MAP3K133.07338941
6TESK22.90999968
7MAP4K12.74314639
8BCKDK2.73719798
9ITK2.02391227
10RIPK42.00897114
11SYK1.62517332
12BTK1.54432096
13TEC1.52115099
14ADRBK21.50146435
15MUSK1.44041146
16JAK31.41829565
17GRK11.38587736
18LRRK21.38563419
19STK161.37236965
20CAMKK21.36791913
21PRKCQ1.32066441
22SIK21.29565196
23LIMK11.18359839
24CSK1.08892335
25GRK61.06701122
26LCK1.04758641
27TYRO31.04209654
28TESK11.00799640
29FES0.99305872
30GRK70.97099634
31CDK190.94911422
32ZAP700.94807402
33BMPR1B0.93998340
34VRK20.92905022
35TIE10.92904986
36MAP4K20.92532371
37FRK0.85361717
38TAOK30.85039598
39LYN0.83466844
40WNK40.83143791
41PINK10.82694841
42IKBKB0.75245731
43MAPK130.74063326
44INSRR0.70758626
45ZAK0.67412662
46NME10.65562990
47MYLK0.65198768
48WNK30.65147999
49OBSCN0.60031834
50MAP3K120.59758613
51MAPKAPK30.59744448
52MAP2K70.58686413
53FYN0.56683253
54DYRK20.55603133
55IGF1R0.53077788
56CSNK1G30.51357903
57JAK20.50906202
58MAP3K140.50011386
59BRSK20.46860921
60MAP3K110.46264586
61MAP3K70.44925155
62ROCK10.43208633
63RPS6KA50.39650838
64PAK10.38855994
65PRKCA0.38785093
66CSNK1G20.37879965
67NEK20.36587317
68KIT0.35810067
69NTRK20.35501434
70PRKCD0.35177720
71PAK60.35057577
72ADRBK10.34737973
73PDK20.34184235
74MST40.34046623
75MAPK150.33464111
76VRK10.32476996
77CHUK0.30782409
78NUAK10.30687857
79PRKACA0.30494863
80MARK30.30100005
81PDK10.28304574
82HCK0.26287218
83PIK3CA0.25901153
84PRKCH0.25703386
85CSNK1A1L0.25217456
86CSNK1G10.25179809
87IKBKE0.23767991
88CLK10.22539808
89TNK20.21946506
90PIK3CG0.21254559
91MAPKAPK20.20780817
92INSR0.20704891
93OXSR10.19650683
94PRKCZ0.19456697
95PAK30.18778052
96DAPK10.18607514
97CAMK2A0.18320179
98PRKCB0.18297995
99SRC0.17152111
100PIM20.16706810

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053405.19223652
2Proteasome_Homo sapiens_hsa030503.55946197
3Ribosome_Homo sapiens_hsa030103.24037255
4Oxidative phosphorylation_Homo sapiens_hsa001903.03552684
5Autoimmune thyroid disease_Homo sapiens_hsa053202.77626596
6Graft-versus-host disease_Homo sapiens_hsa053322.76247969
7Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.70961703
8Hematopoietic cell lineage_Homo sapiens_hsa046402.60089449
9Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.59213560
10Parkinsons disease_Homo sapiens_hsa050122.55356525
11Allograft rejection_Homo sapiens_hsa053302.45874591
12T cell receptor signaling pathway_Homo sapiens_hsa046602.43377976
13Rheumatoid arthritis_Homo sapiens_hsa053232.19573252
14Antigen processing and presentation_Homo sapiens_hsa046122.16243868
15Type I diabetes mellitus_Homo sapiens_hsa049402.14798837
16Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.11457242
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.89994577
18SNARE interactions in vesicular transport_Homo sapiens_hsa041301.63948414
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63285758
20Alzheimers disease_Homo sapiens_hsa050101.61568497
21Cardiac muscle contraction_Homo sapiens_hsa042601.60925833
22Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.52891311
23Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.49203339
24Phototransduction_Homo sapiens_hsa047441.47508821
25NF-kappa B signaling pathway_Homo sapiens_hsa040641.41312235
26Huntingtons disease_Homo sapiens_hsa050161.40156359
27Protein export_Homo sapiens_hsa030601.34151038
28Measles_Homo sapiens_hsa051621.33129066
29Salmonella infection_Homo sapiens_hsa051321.31004902
30RNA polymerase_Homo sapiens_hsa030201.27104078
31Viral myocarditis_Homo sapiens_hsa054161.22129830
32Nitrogen metabolism_Homo sapiens_hsa009101.20751647
33Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14107768
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13871551
35Shigellosis_Homo sapiens_hsa051311.10288860
36Asthma_Homo sapiens_hsa053101.04949041
37Intestinal immune network for IgA production_Homo sapiens_hsa046720.99569259
38Staphylococcus aureus infection_Homo sapiens_hsa051500.97055662
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96801766
40Malaria_Homo sapiens_hsa051440.91410652
41Linoleic acid metabolism_Homo sapiens_hsa005910.80355459
42Chemokine signaling pathway_Homo sapiens_hsa040620.80007397
43Olfactory transduction_Homo sapiens_hsa047400.78991252
44NOD-like receptor signaling pathway_Homo sapiens_hsa046210.77732591
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76725569
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.76518057
47Systemic lupus erythematosus_Homo sapiens_hsa053220.73010943
48Steroid biosynthesis_Homo sapiens_hsa001000.72399018
49Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.72393204
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72039477
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71813049
52Nicotine addiction_Homo sapiens_hsa050330.70425629
53Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69596157
54Collecting duct acid secretion_Homo sapiens_hsa049660.69127958
55Caffeine metabolism_Homo sapiens_hsa002320.68589645
56Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.64403106
57Sulfur metabolism_Homo sapiens_hsa009200.64087671
58Retinol metabolism_Homo sapiens_hsa008300.62949580
59Taste transduction_Homo sapiens_hsa047420.62769574
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61617583
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.61226151
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59641595
63Tyrosine metabolism_Homo sapiens_hsa003500.54211736
64Glycerolipid metabolism_Homo sapiens_hsa005610.53710724
65Chemical carcinogenesis_Homo sapiens_hsa052040.50073132
66Morphine addiction_Homo sapiens_hsa050320.49428677
67Amphetamine addiction_Homo sapiens_hsa050310.49282525
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.45620556
69Homologous recombination_Homo sapiens_hsa034400.43399907
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41343357
71Pyrimidine metabolism_Homo sapiens_hsa002400.38240496
72ABC transporters_Homo sapiens_hsa020100.38239551
73Alcoholism_Homo sapiens_hsa050340.38070622
74Primary bile acid biosynthesis_Homo sapiens_hsa001200.37706719
75Apoptosis_Homo sapiens_hsa042100.37109017
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35516521
77Peroxisome_Homo sapiens_hsa041460.34221241
78African trypanosomiasis_Homo sapiens_hsa051430.33355891
79HTLV-I infection_Homo sapiens_hsa051660.33286204
80Purine metabolism_Homo sapiens_hsa002300.33148066
81TNF signaling pathway_Homo sapiens_hsa046680.33050919
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31165318
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30783206
84Butanoate metabolism_Homo sapiens_hsa006500.29415374
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.28819438
86Cholinergic synapse_Homo sapiens_hsa047250.28791439
87Maturity onset diabetes of the young_Homo sapiens_hsa049500.28302010
88Pertussis_Homo sapiens_hsa051330.27178146
89GABAergic synapse_Homo sapiens_hsa047270.27170357
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.26589413
91Basal transcription factors_Homo sapiens_hsa030220.26434713
92RNA degradation_Homo sapiens_hsa030180.25138120
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24684558
94Regulation of autophagy_Homo sapiens_hsa041400.24399308
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24156914
96Herpes simplex infection_Homo sapiens_hsa051680.23775519
97Cocaine addiction_Homo sapiens_hsa050300.23506583
98Serotonergic synapse_Homo sapiens_hsa047260.21196927
99Metabolic pathways_Homo sapiens_hsa011000.19907445
100Galactose metabolism_Homo sapiens_hsa000520.17598929

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