TMSB4XP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.17613015
2negative T cell selection (GO:0043383)5.84376988
3regulation of regulatory T cell differentiation (GO:0045589)5.79561096
4regulation of B cell receptor signaling pathway (GO:0050855)5.70322761
5negative thymic T cell selection (GO:0045060)5.64154938
6positive thymic T cell selection (GO:0045059)5.61927038
7negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.60312707
8negative regulation of cell killing (GO:0031342)5.60312707
9positive T cell selection (GO:0043368)5.57643877
10antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.57120056
11regulation of gamma-delta T cell differentiation (GO:0045586)5.36011740
12positive regulation of B cell differentiation (GO:0045579)5.32482074
13tolerance induction (GO:0002507)5.28927879
14regulation of gamma-delta T cell activation (GO:0046643)5.18503406
15negative regulation of T cell mediated immunity (GO:0002710)4.96760243
16thymic T cell selection (GO:0045061)4.91156372
17positive regulation of tolerance induction (GO:0002645)4.86280901
18T cell selection (GO:0045058)4.82769520
19positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.78447049
20B cell receptor signaling pathway (GO:0050853)4.76804994
21regulation of T cell tolerance induction (GO:0002664)4.61415057
22positive regulation of granulocyte differentiation (GO:0030854)4.60040918
23response to interleukin-15 (GO:0070672)4.59576512
24regulation of B cell differentiation (GO:0045577)4.55957448
25cellular response to interleukin-15 (GO:0071350)4.52861160
26regulation of isotype switching to IgG isotypes (GO:0048302)4.35637871
27negative regulation of B cell mediated immunity (GO:0002713)4.30780396
28negative regulation of immunoglobulin mediated immune response (GO:0002890)4.30780396
29negative regulation of B cell proliferation (GO:0030889)4.24682361
30regulation of tolerance induction (GO:0002643)4.15730969
31negative regulation of lymphocyte mediated immunity (GO:0002707)4.13925589
32regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.05973282
33retrograde transport, vesicle recycling within Golgi (GO:0000301)4.00027950
34hepatocyte apoptotic process (GO:0097284)3.99346522
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99126020
36protein targeting to Golgi (GO:0000042)3.92610373
37antigen receptor-mediated signaling pathway (GO:0050851)3.91553881
38establishment of protein localization to Golgi (GO:0072600)3.86836575
39antigen processing and presentation of endogenous antigen (GO:0019883)3.81192605
40T cell migration (GO:0072678)3.79254148
41T cell receptor signaling pathway (GO:0050852)3.75387320
42positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.74334651
43activated T cell proliferation (GO:0050798)3.70314727
44negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.65539487
45antigen processing and presentation via MHC class Ib (GO:0002475)3.63358234
46negative regulation of leukocyte mediated immunity (GO:0002704)3.57437847
47dendritic cell migration (GO:0036336)3.53577045
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.47567155
49regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.46752967
50leukocyte aggregation (GO:0070486)3.40857349
51positive regulation by symbiont of host defense response (GO:0052509)3.38808374
52modulation by symbiont of host defense response (GO:0052031)3.38808374
53modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.38808374
54modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.38808374
55positive regulation by organism of defense response of other organism involved in symbiotic interact3.38808374
56modulation by symbiont of host immune response (GO:0052553)3.38808374
57negative regulation of adaptive immune response (GO:0002820)3.38701990
58regulation of alpha-beta T cell proliferation (GO:0046640)3.38481483
59microglial cell activation (GO:0001774)3.38229215
60antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.37049211
61regulation of granulocyte differentiation (GO:0030852)3.31283861
62negative regulation of interleukin-12 production (GO:0032695)3.30656354
63regulation of interleukin-2 biosynthetic process (GO:0045076)3.29090330
64dendritic cell chemotaxis (GO:0002407)3.28119281
65negative regulation of B cell activation (GO:0050869)3.25386227
66negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)3.20698271
67positive regulation of alpha-beta T cell proliferation (GO:0046641)3.18745237
68histone H3-K36 demethylation (GO:0070544)3.18412462
69mast cell activation (GO:0045576)3.15382472
70positive regulation of interleukin-4 production (GO:0032753)3.15055608
71phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.12494472
72negative regulation of T cell apoptotic process (GO:0070233)3.12473290
73T cell mediated immunity (GO:0002456)3.11868077
74cellular extravasation (GO:0045123)3.09984428
75T cell homeostasis (GO:0043029)3.08384140
76respiratory burst (GO:0045730)3.04563911
77response to type I interferon (GO:0034340)3.02351087
78regulation of T cell mediated cytotoxicity (GO:0001914)3.00915562
79cellular response to type I interferon (GO:0071357)3.00882671
80type I interferon signaling pathway (GO:0060337)3.00882671
81detection of molecule of bacterial origin (GO:0032490)2.99821765
82interferon-gamma production (GO:0032609)2.97854704
83immunoglobulin mediated immune response (GO:0016064)2.96100260
84T cell costimulation (GO:0031295)2.92472046
85actin nucleation (GO:0045010)2.92342540
86immune response-activating cell surface receptor signaling pathway (GO:0002429)2.91599003
87lymphocyte costimulation (GO:0031294)2.87998881
88cytidine deamination (GO:0009972)2.87071011
89cytidine metabolic process (GO:0046087)2.87071011
90cytidine catabolic process (GO:0006216)2.87071011
91neutrophil mediated immunity (GO:0002446)2.85583616
92pyrimidine ribonucleoside catabolic process (GO:0046133)2.85419714
93regulation of necroptotic process (GO:0060544)2.85233366
94macrophage activation involved in immune response (GO:0002281)2.84605645
95positive regulation of humoral immune response (GO:0002922)2.84136765
96maintenance of gastrointestinal epithelium (GO:0030277)2.83522869
97negative regulation of myotube differentiation (GO:0010832)2.80220802
98B cell homeostasis (GO:0001782)2.78388652
99negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.78300133
100alpha-beta T cell differentiation (GO:0046632)2.75878101

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.47552173
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.87979779
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.82134826
4IRF1_21803131_ChIP-Seq_MONOCYTES_Human4.13143220
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.85262009
6RUNX_20019798_ChIP-Seq_JUKART_Human3.80277070
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.70393224
8STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.64302873
9MYB_26560356_Chip-Seq_TH2_Human3.27504975
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16376965
11SMAD_19615063_ChIP-ChIP_OVARY_Human3.06109378
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03944677
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.87881389
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.74739139
15MYB_26560356_Chip-Seq_TH1_Human2.60219363
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.58988560
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.48906013
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.43100700
19GATA3_27048872_Chip-Seq_THYMUS_Human2.40111098
20SPI1_23127762_ChIP-Seq_K562_Human2.36856120
21SCL_19346495_ChIP-Seq_HPC-7_Human2.22065658
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13568994
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.12083999
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10888559
25SPI1_23547873_ChIP-Seq_NB4_Human2.08507973
26MAF_26560356_Chip-Seq_TH1_Human2.05653212
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.03065983
28VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.94834470
29UTX_26944678_Chip-Seq_JUKART_Human1.90435867
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.84810468
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.84698021
32GATA3_26560356_Chip-Seq_TH2_Human1.82454392
33Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81592218
34RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.62440924
35FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.59340027
36MYC_22102868_ChIP-Seq_BL_Human1.57127820
37ELF1_17652178_ChIP-ChIP_JURKAT_Human1.54740366
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52052800
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.51012991
40GATA1_22025678_ChIP-Seq_K562_Human1.48147609
41VDR_24787735_ChIP-Seq_THP-1_Human1.45278678
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.44694147
43MAF_26560356_Chip-Seq_TH2_Human1.44426731
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41096365
45ESR1_20079471_ChIP-ChIP_T-47D_Human1.40353143
46SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33141006
47GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28078655
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.25395302
49RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.24376735
50GATA1_19941826_ChIP-Seq_K562_Human1.24296127
51GATA2_19941826_ChIP-Seq_K562_Human1.23469547
52AR_21572438_ChIP-Seq_LNCaP_Human1.22723768
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.21589066
54VDR_24763502_ChIP-Seq_THP-1_Human1.20883244
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19729276
56PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17799101
57STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14871023
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.13153017
59PU_27001747_Chip-Seq_BMDM_Mouse1.11193739
60SMRT_27268052_Chip-Seq_Bcells_Human1.04522272
61DROSHA_22980978_ChIP-Seq_HELA_Human1.04391015
62MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.03912498
63VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01873315
64CIITA_25753668_ChIP-Seq_RAJI_Human1.00455906
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.00250665
66NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97922418
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97119081
68TP53_16413492_ChIP-PET_HCT116_Human0.96751385
69GATA2_22383799_ChIP-Seq_G1ME_Mouse0.94690058
70GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92898506
71GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92365975
72NOTCH1_21737748_ChIP-Seq_TLL_Human0.91031043
73FOXO3_23340844_ChIP-Seq_DLD1_Human0.89360955
74EGR1_19374776_ChIP-ChIP_THP-1_Human0.86301694
75LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.85995786
76FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84852559
77CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.83268894
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.83026582
79TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82608423
80GATA3_26560356_Chip-Seq_TH1_Human0.81933904
81TCF7_22412390_ChIP-Seq_EML_Mouse0.81249313
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80940023
83WDR5_24793694_ChIP-Seq_LNCAP_Human0.79947290
84VDR_21846776_ChIP-Seq_THP-1_Human0.78158384
85TP63_17297297_ChIP-ChIP_HaCaT_Human0.76700836
86CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76052934
87CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.75169941
88PRDM14_20953172_ChIP-Seq_ESCs_Human0.74288116
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.73352118
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73305806
91ER_23166858_ChIP-Seq_MCF-7_Human0.72091784
92TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.71262392
93TDRD3_21172665_ChIP-Seq_MCF-7_Human0.68239971
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.68221838
95FLI1_27457419_Chip-Seq_LIVER_Mouse0.68107030
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.66665290
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.66654930
98KDM2B_26808549_Chip-Seq_SUP-B15_Human0.66212761
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.66182285
100NFE2_27457419_Chip-Seq_LIVER_Mouse0.66066812

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003763_abnormal_thymus_physiology4.01299382
2MP0001835_abnormal_antigen_presentation3.70981013
3MP0005671_abnormal_response_to3.67937358
4MP0001800_abnormal_humoral_immune3.33009083
5MP0003866_abnormal_defecation3.18876351
6MP0000569_abnormal_digit_pigmentation3.13941034
7MP0000685_abnormal_immune_system2.83069458
8MP0005000_abnormal_immune_tolerance2.81452196
9MP0000465_gastrointestinal_hemorrhage2.81005711
10MP0001790_abnormal_immune_system2.77020914
11MP0005387_immune_system_phenotype2.77020914
12MP0001873_stomach_inflammation2.56054541
13MP0002420_abnormal_adaptive_immunity2.52129447
14MP0008260_abnormal_autophagy2.51535460
15MP0002723_abnormal_immune_serum2.50047568
16MP0002452_abnormal_antigen_presenting2.48138207
17MP0001819_abnormal_immune_cell2.44592472
18MP0004381_abnormal_hair_follicle2.34577159
19MP0004947_skin_inflammation2.34144606
20MP0002405_respiratory_system_inflammati2.32913155
21MP0005025_abnormal_response_to2.31784970
22MP0002398_abnormal_bone_marrow2.29612182
23MP0009785_altered_susceptibility_to2.26775830
24MP0003436_decreased_susceptibility_to2.18444040
25MP0003300_gastrointestinal_ulcer2.17163868
26MP0008004_abnormal_stomach_pH2.12199809
27MP0002166_altered_tumor_susceptibility2.10756892
28MP0000703_abnormal_thymus_morphology2.07008129
29MP0002419_abnormal_innate_immunity2.06892709
30MP0010155_abnormal_intestine_physiology2.05279563
31MP0000716_abnormal_immune_system2.05225536
32MP0003724_increased_susceptibility_to1.97065575
33MP0002722_abnormal_immune_system1.95745488
34MP0000689_abnormal_spleen_morphology1.93301631
35MP0005310_abnormal_salivary_gland1.93168365
36MP0003045_fibrosis1.92897076
37MP0005464_abnormal_platelet_physiology1.79460149
38MP0002148_abnormal_hypersensitivity_rea1.78822649
39MP0009333_abnormal_splenocyte_physiolog1.64366742
40MP0002396_abnormal_hematopoietic_system1.59807240
41MP0002429_abnormal_blood_cell1.58628830
42MP0003303_peritoneal_inflammation1.55034659
43MP0002277_abnormal_respiratory_mucosa1.52972263
44MP0001845_abnormal_inflammatory_respons1.52263848
45MP0005075_abnormal_melanosome_morpholog1.50221248
46MP0001851_eye_inflammation1.43973715
47MP0003091_abnormal_cell_migration1.42504776
48MP0003656_abnormal_erythrocyte_physiolo1.39130585
49MP0001853_heart_inflammation1.36769433
50MP0002006_tumorigenesis1.32752138
51MP0008057_abnormal_DNA_replication1.32602965
52MP0003646_muscle_fatigue1.14831517
53MP0000015_abnormal_ear_pigmentation1.13985539
54MP0004808_abnormal_hematopoietic_stem1.12044794
55MP0001663_abnormal_digestive_system1.09955949
56MP0003172_abnormal_lysosome_physiology1.09301475
57MP0005275_abnormal_skin_tensile1.09119529
58MP0005083_abnormal_biliary_tract1.06226093
59MP0002332_abnormal_exercise_endurance0.99480096
60MP0004883_abnormal_blood_vessel0.97772073
61MP0008995_early_reproductive_senescence0.97451371
62MP0000858_altered_metastatic_potential0.94608393
63MP0002933_joint_inflammation0.92575936
64MP0002019_abnormal_tumor_incidence0.92535986
65MP0005377_hearing/vestibular/ear_phenot0.92062279
66MP0003878_abnormal_ear_physiology0.92062279
67MP0005174_abnormal_tail_pigmentation0.88099363
68MP0003183_abnormal_peptide_metabolism0.87298815
69MP0005451_abnormal_body_composition0.86922691
70MP0009763_increased_sensitivity_to0.86433368
71MP0003828_pulmonary_edema0.84135797
72MP0006082_CNS_inflammation0.83451625
73MP0003787_abnormal_imprinting0.83382332
74MP0003448_altered_tumor_morphology0.82001442
75MP0006054_spinal_hemorrhage0.81643241
76MP0003868_abnormal_feces_composition0.81292972
77MP0010307_abnormal_tumor_latency0.80193165
78MP0008469_abnormal_protein_level0.80115496
79MP0002928_abnormal_bile_duct0.78428779
80MP0005381_digestive/alimentary_phenotyp0.76964652
81MP0002168_other_aberrant_phenotype0.76467286
82MP0001533_abnormal_skeleton_physiology0.68347125
83MP0009764_decreased_sensitivity_to0.65656637
84MP0008438_abnormal_cutaneous_collagen0.64052478
85MP0001958_emphysema0.63732264
86MP0003279_aneurysm0.63690257
87MP0003221_abnormal_cardiomyocyte_apopto0.62267298
88MP0002136_abnormal_kidney_physiology0.59287142
89MP0002060_abnormal_skin_morphology0.58470279
90MP0002796_impaired_skin_barrier0.57559454
91MP0003252_abnormal_bile_duct0.57548655
92MP0005621_abnormal_cell_physiology0.57187998
93MP0005166_decreased_susceptibility_to0.56843267
94MP0004134_abnormal_chest_morphology0.56650060
95MP0005409_darkened_coat_color0.56095969
96MP0004484_altered_response_of0.55724821
97MP0000249_abnormal_blood_vessel0.54186451
98MP0001765_abnormal_ion_homeostasis0.50943063
99MP0010234_abnormal_vibrissa_follicle0.50243727
100MP0009765_abnormal_xenobiotic_induced0.49945984

Predicted human phenotypes

RankGene SetZ-score
1Autoimmune hemolytic anemia (HP:0001890)6.19539663
2T lymphocytopenia (HP:0005403)6.10939996
3Abnormality of T cell number (HP:0011839)5.62828183
4Parkinsonism with favorable response to dopaminergic medication (HP:0002548)5.27283422
5Recurrent bacterial skin infections (HP:0005406)4.54262823
6Eczematoid dermatitis (HP:0000976)4.54159955
7Recurrent bronchitis (HP:0002837)4.40956161
8Elevated erythrocyte sedimentation rate (HP:0003565)4.13938458
9Recurrent abscess formation (HP:0002722)4.12545368
10Abnormality of T cells (HP:0002843)4.04340039
11IgM deficiency (HP:0002850)3.99900862
12Recurrent fungal infections (HP:0002841)3.94558021
13Abnormality of the fingertips (HP:0001211)3.91527951
14Chronic diarrhea (HP:0002028)3.89265468
15Hypoplasia of the thymus (HP:0000778)3.77272516
16Stomatitis (HP:0010280)3.77137857
17Chronic mucocutaneous candidiasis (HP:0002728)3.75224077
18Recurrent cutaneous fungal infections (HP:0011370)3.75224077
19IgG deficiency (HP:0004315)3.63175663
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.45961487
21Recurrent skin infections (HP:0001581)3.40051559
22Severe combined immunodeficiency (HP:0004430)3.39339379
23Thyroiditis (HP:0100646)3.37041124
24Spontaneous hematomas (HP:0007420)3.35932436
25Lymphopenia (HP:0001888)3.31791007
26Leukocytosis (HP:0001974)3.30933807
27Peritonitis (HP:0002586)3.28213776
28Abnormality of eosinophils (HP:0001879)3.27357658
29Agammaglobulinemia (HP:0004432)3.24897483
30Gingivitis (HP:0000230)3.23152238
31Gastrointestinal infarctions (HP:0005244)3.22477609
32Meningitis (HP:0001287)3.16497637
33Vasculitis (HP:0002633)3.16349165
34Abnormality of cells of the lymphoid lineage (HP:0012140)3.07979023
35Inflammation of the large intestine (HP:0002037)3.07447930
36Retrobulbar optic neuritis (HP:0100654)3.07205254
37Optic neuritis (HP:0100653)3.07205254
38Myositis (HP:0100614)3.06975828
39IgA deficiency (HP:0002720)3.01370029
40Recurrent viral infections (HP:0004429)2.97906542
41Eosinophilia (HP:0001880)2.95159638
42Recurrent gram-negative bacterial infections (HP:0005420)2.94754191
43Colitis (HP:0002583)2.93732385
44Gastrointestinal inflammation (HP:0004386)2.93586960
45Abnormality of macrophages (HP:0004311)2.86110915
46Encephalitis (HP:0002383)2.79761797
47Orchitis (HP:0100796)2.77255439
48Mediastinal lymphadenopathy (HP:0100721)2.74979440
49Gingival bleeding (HP:0000225)2.72066000
50Granulocytopenia (HP:0001913)2.71388191
51Aplastic anemia (HP:0001915)2.68663748
52Combined immunodeficiency (HP:0005387)2.63835014
53Chest pain (HP:0100749)2.62930968
54Panhypogammaglobulinemia (HP:0003139)2.59837336
55Slow saccadic eye movements (HP:0000514)2.52999581
56Prolonged bleeding time (HP:0003010)2.52217835
57Abnormality of T cell physiology (HP:0011840)2.51349052
58Chronic obstructive pulmonary disease (HP:0006510)2.48932516
59Obstructive lung disease (HP:0006536)2.48932516
60Villous atrophy (HP:0011473)2.47182420
61Abnormality of small intestinal villus morphology (HP:0011472)2.47182420
62Urticaria (HP:0001025)2.46209598
63Pulmonary infiltrates (HP:0002113)2.45296243
64Keratoconjunctivitis sicca (HP:0001097)2.45122881
65Gastrointestinal stroma tumor (HP:0100723)2.43995112
66Epistaxis (HP:0000421)2.42218855
67Periodontitis (HP:0000704)2.41528939
68Pustule (HP:0200039)2.41512099
69Bilateral sensorineural hearing impairment (HP:0008619)2.40671462
70Hemoptysis (HP:0002105)2.40336809
71Cellulitis (HP:0100658)2.40070098
72Bronchitis (HP:0012387)2.39536902
73Increased IgM level (HP:0003496)2.33598173
74Abnormality of incisor morphology (HP:0011063)2.33292093
75Abnormality of the columella (HP:0009929)2.31753491
76Abnormality of the peritoneum (HP:0002585)2.29294987
77Increased IgE level (HP:0003212)2.27755267
78Lymphoma (HP:0002665)2.25019599
79Abnormality of the prostate (HP:0008775)2.19899792
80Acute hepatic failure (HP:0006554)2.16398556
81Keratoconjunctivitis (HP:0001096)2.15334925
82Ileus (HP:0002595)2.12946900
83Prominent nose (HP:0000448)2.10627971
84Long clavicles (HP:0000890)2.09669242
85Gangrene (HP:0100758)2.08423112
86Thick nail (HP:0001805)2.08226309
87Verrucae (HP:0200043)2.05991378
88Papilloma (HP:0012740)2.05991378
89Hyperkalemia (HP:0002153)2.04333389
90Ureteral obstruction (HP:0006000)2.02800801
91Aplasia/Hypoplasia of the thymus (HP:0010515)2.01103578
92Sepsis (HP:0100806)1.96942489
93Ureteral stenosis (HP:0000071)1.90703335
94Viral hepatitis (HP:0006562)1.89316271
95Hypergammaglobulinemia (HP:0010702)1.87441860
96Autoimmune thrombocytopenia (HP:0001973)1.87025561
97Spondylolisthesis (HP:0003302)1.86115023
98Arterial thrombosis (HP:0004420)1.82754349
99Pulmonary embolism (HP:0002204)1.81257820
100Skin ulcer (HP:0200042)1.75854483

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.83277846
2BLK3.63152067
3MAP4K13.47468750
4RIPK43.41956075
5FES2.67735727
6MAP3K132.47162179
7BTK2.35151507
8SYK2.30594487
9PIK3CG2.24971852
10CSK2.18578785
11FGR2.13999668
12GRK62.10204607
13JAK31.99973125
14WNK11.97843598
15ITK1.94699758
16IKBKE1.89168593
17TEC1.82821846
18ZAP701.79264934
19CDK121.78499696
20NLK1.76905050
21LCK1.57270027
22TYK21.53256077
23WNK41.52300305
24CSF1R1.50649641
25LRRK21.49199518
26MAP3K141.44244329
27JAK11.42123475
28MST1R1.39869080
29LYN1.36324691
30TAOK31.34539302
31IRAK41.32782854
32TRPM71.30943915
33HCK1.30233854
34FGFR41.26809193
35MAP3K101.24305422
36MARK31.20090872
37FGFR31.13941378
38ERBB21.08922484
39MARK21.04405671
40SGK21.02567515
41MST40.99367023
42KDR0.98835344
43BMPR20.97983591
44STK40.96192673
45PDGFRB0.92613042
46PRKCQ0.91479660
47JAK20.90365437
48PIM10.83270796
49STK100.80843780
50PTK2B0.80768436
51IKBKB0.79919300
52TNK20.79484002
53SGK30.79092723
54MAP2K30.78900352
55FYN0.78069768
56EPHB10.76957556
57CAMK1D0.75467655
58GRK50.72721619
59NEK60.72290676
60SGK10.71076505
61CDC42BPA0.70218747
62ERN10.67198064
63CAMKK20.66632082
64CDK40.63917903
65PDK10.61292885
66PIK3CA0.59717495
67FRK0.58841231
68CAMK1G0.57953509
69KIT0.57001440
70MAP3K70.56271627
71SGK4940.55296606
72SGK2230.55296606
73MELK0.54423364
74EGFR0.49173462
75CHUK0.48270397
76CLK10.47983973
77IRAK10.47055838
78TAOK10.46640557
79EPHA30.46437957
80MAP3K30.44907530
81MAP3K10.43388246
82IGF1R0.41952134
83YES10.40706552
84PAK30.39472941
85SCYL20.39355811
86MAPK70.39110192
87PRKAA20.37687058
88OBSCN0.37621336
89PTK60.36273490
90AKT30.35303686
91CAMKK10.34375207
92SIK20.33986535
93PLK20.33656986
94MATK0.32766103
95TBK10.32542072
96CAMK40.31292937
97RET0.29133188
98STK390.29067712
99BRD40.24225305
100CDK60.23848635

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.40543120
2T cell receptor signaling pathway_Homo sapiens_hsa046602.89869744
3B cell receptor signaling pathway_Homo sapiens_hsa046622.78465877
4Autoimmune thyroid disease_Homo sapiens_hsa053202.52881093
5Hematopoietic cell lineage_Homo sapiens_hsa046402.49591983
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.48512404
7Measles_Homo sapiens_hsa051622.27940830
8Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.21788445
9Allograft rejection_Homo sapiens_hsa053302.20924429
10Graft-versus-host disease_Homo sapiens_hsa053322.18469283
11Leishmaniasis_Homo sapiens_hsa051402.15450974
12Osteoclast differentiation_Homo sapiens_hsa043802.06700090
13Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.06023787
14NF-kappa B signaling pathway_Homo sapiens_hsa040642.03130342
15Staphylococcus aureus infection_Homo sapiens_hsa051501.93008879
16Antigen processing and presentation_Homo sapiens_hsa046121.68510581
17Type I diabetes mellitus_Homo sapiens_hsa049401.63020068
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.59922016
19Malaria_Homo sapiens_hsa051441.57612550
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.57605724
21Chemokine signaling pathway_Homo sapiens_hsa040621.51485862
22Jak-STAT signaling pathway_Homo sapiens_hsa046301.50054060
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.47901503
24Platelet activation_Homo sapiens_hsa046111.44481964
25Non-small cell lung cancer_Homo sapiens_hsa052231.37656252
26Tuberculosis_Homo sapiens_hsa051521.35291406
27Acute myeloid leukemia_Homo sapiens_hsa052211.33610460
28Herpes simplex infection_Homo sapiens_hsa051681.32328001
29Viral myocarditis_Homo sapiens_hsa054161.30600601
30Influenza A_Homo sapiens_hsa051641.23887500
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.23333381
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.22356599
33Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20205899
34Toxoplasmosis_Homo sapiens_hsa051451.16689101
35Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16013498
36Asthma_Homo sapiens_hsa053101.13797853
37Dorso-ventral axis formation_Homo sapiens_hsa043201.11172709
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.05334337
39RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05294244
40Pancreatic cancer_Homo sapiens_hsa052121.04267952
41Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.02714344
42Apoptosis_Homo sapiens_hsa042101.02309975
43Notch signaling pathway_Homo sapiens_hsa043300.99705027
44TNF signaling pathway_Homo sapiens_hsa046680.99392907
45Hepatitis B_Homo sapiens_hsa051610.97079547
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97003568
47Viral carcinogenesis_Homo sapiens_hsa052030.96812841
48Chronic myeloid leukemia_Homo sapiens_hsa052200.91353302
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90135112
50HTLV-I infection_Homo sapiens_hsa051660.88959247
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88809384
52Renal cell carcinoma_Homo sapiens_hsa052110.88594857
53Inositol phosphate metabolism_Homo sapiens_hsa005620.87661896
54FoxO signaling pathway_Homo sapiens_hsa040680.86119663
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.85994018
56Legionellosis_Homo sapiens_hsa051340.81144829
57Long-term potentiation_Homo sapiens_hsa047200.80520302
58Epstein-Barr virus infection_Homo sapiens_hsa051690.79202168
59Amoebiasis_Homo sapiens_hsa051460.72705439
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72616683
61Shigellosis_Homo sapiens_hsa051310.70566142
62VEGF signaling pathway_Homo sapiens_hsa043700.69720308
63Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69034941
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.68940359
65Rheumatoid arthritis_Homo sapiens_hsa053230.66397039
66Hepatitis C_Homo sapiens_hsa051600.66097862
67Endometrial cancer_Homo sapiens_hsa052130.65627910
68Prolactin signaling pathway_Homo sapiens_hsa049170.65477118
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64688829
70Transcriptional misregulation in cancer_Homo sapiens_hsa052020.64534551
71Endocytosis_Homo sapiens_hsa041440.63728211
72Phagosome_Homo sapiens_hsa041450.63447651
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61273648
74HIF-1 signaling pathway_Homo sapiens_hsa040660.60708081
75Salmonella infection_Homo sapiens_hsa051320.60460443
76ErbB signaling pathway_Homo sapiens_hsa040120.59186433
77Choline metabolism in cancer_Homo sapiens_hsa052310.55652531
78African trypanosomiasis_Homo sapiens_hsa051430.55573716
79Glioma_Homo sapiens_hsa052140.55001158
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.54890699
81mTOR signaling pathway_Homo sapiens_hsa041500.54876964
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.54259151
83Systemic lupus erythematosus_Homo sapiens_hsa053220.54146935
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50688322
85Prostate cancer_Homo sapiens_hsa052150.50294885
86MicroRNAs in cancer_Homo sapiens_hsa052060.47268114
87Focal adhesion_Homo sapiens_hsa045100.45613170
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.43722012
89GnRH signaling pathway_Homo sapiens_hsa049120.41334455
90Insulin resistance_Homo sapiens_hsa049310.41047990
91Pertussis_Homo sapiens_hsa051330.40022779
92ABC transporters_Homo sapiens_hsa020100.39542332
93Ras signaling pathway_Homo sapiens_hsa040140.39417183
94Proteoglycans in cancer_Homo sapiens_hsa052050.39308984
95MAPK signaling pathway_Homo sapiens_hsa040100.39295753
96Rap1 signaling pathway_Homo sapiens_hsa040150.38565501
97Small cell lung cancer_Homo sapiens_hsa052220.38071832
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.37818980
99Colorectal cancer_Homo sapiens_hsa052100.37710033
100Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35953545

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