TMPRSS13

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the type II transmembrane serine protease family. Transmembrane serine proteases are regulated by protease inhibitors and known to function in development, homeostasis, infection, and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transepithelial transport (GO:0070633)6.61545439
2copper ion transport (GO:0006825)5.89666262
3hair cycle (GO:0042633)5.77749892
4molting cycle (GO:0042303)5.77749892
5branching involved in labyrinthine layer morphogenesis (GO:0060670)5.68029592
6cellular copper ion homeostasis (GO:0006878)5.25791541
7keratinocyte differentiation (GO:0030216)5.20360113
8cell differentiation involved in metanephros development (GO:0072202)5.04158477
9generation of neurons (GO:0048699)4.96112646
10bundle of His cell to Purkinje myocyte communication (GO:0086069)4.91631155
11regulation of vitamin D biosynthetic process (GO:0060556)4.75695023
12diol metabolic process (GO:0034311)4.61756178
13antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.56284043
14antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.56284043
15metanephric mesenchyme development (GO:0072075)4.48346709
16myoblast migration (GO:0051451)4.44559475
17regulation of chronic inflammatory response (GO:0002676)4.33228865
18sperm capacitation (GO:0048240)4.22912850
19copper ion homeostasis (GO:0055070)4.19964644
20positive regulation of chemokine secretion (GO:0090197)4.12507031
21epidermal cell differentiation (GO:0009913)4.06975210
22sphingosine metabolic process (GO:0006670)4.06472237
23positive regulation of keratinocyte differentiation (GO:0045618)4.00698140
24facial nerve structural organization (GO:0021612)3.93195531
25intestinal epithelial cell development (GO:0060576)3.89793373
26kidney mesenchyme development (GO:0072074)3.89360589
27epidermis development (GO:0008544)3.86219249
28positive regulation of branching involved in ureteric bud morphogenesis (GO:0090190)3.84090333
29prostate gland growth (GO:0060736)3.78124709
30regulation of T-helper 1 cell differentiation (GO:0045625)3.77709326
31postsynaptic membrane organization (GO:0001941)3.76203668
32antigen processing and presentation of endogenous antigen (GO:0019883)3.75857011
33regulation of natural killer cell differentiation (GO:0032823)3.73152645
34opioid receptor signaling pathway (GO:0038003)3.69201573
35polyketide metabolic process (GO:0030638)3.66370712
36doxorubicin metabolic process (GO:0044598)3.66370712
37daunorubicin metabolic process (GO:0044597)3.66370712
38regulation of chemokine secretion (GO:0090196)3.64954109
39regulation of branching involved in ureteric bud morphogenesis (GO:0090189)3.64592615
40keratinocyte proliferation (GO:0043616)3.62871414
41positive regulation of epidermis development (GO:0045684)3.62505366
42keratinocyte development (GO:0003334)3.61308186
43positive regulation of heat generation (GO:0031652)3.59729966
44positive regulation of mesonephros development (GO:0061213)3.59163456
45phosphatidylinositol acyl-chain remodeling (GO:0036149)3.58974446
46inner ear morphogenesis (GO:0042472)3.57770819
47negative regulation of epidermal cell differentiation (GO:0045605)3.57063151
48import into cell (GO:0098657)3.55804690
49cranial nerve morphogenesis (GO:0021602)3.55008351
50lipoxygenase pathway (GO:0019372)3.53362151
51omega-hydroxylase P450 pathway (GO:0097267)3.53302161
52presynaptic membrane assembly (GO:0097105)3.52262364
53positive regulation of epidermal cell differentiation (GO:0045606)3.48390810
54regulation of vitamin metabolic process (GO:0030656)3.47475631
55regulation of mesonephros development (GO:0061217)3.45993765
56viral transcription (GO:0019083)3.44431787
57pattern specification involved in kidney development (GO:0061004)3.43065305
58regulation of fever generation (GO:0031620)3.41164594
59ribosomal small subunit assembly (GO:0000028)3.39680258
60linoleic acid metabolic process (GO:0043651)3.38945927
61regulation of heat generation (GO:0031650)3.38780763
62positive regulation of Cdc42 GTPase activity (GO:0043089)3.37724028
63peptide cross-linking (GO:0018149)3.36918618
64desmosome organization (GO:0002934)3.36133827
65ribosomal small subunit biogenesis (GO:0042274)3.35443698
66lung lobe morphogenesis (GO:0060463)3.33393516
67regulation of female gonad development (GO:2000194)3.31952341
68type I interferon signaling pathway (GO:0060337)3.30188852
69cellular response to type I interferon (GO:0071357)3.30188852
70detection of bacterium (GO:0016045)3.30111736
71ectoderm development (GO:0007398)3.27108317
72response to type I interferon (GO:0034340)3.26717630
73cytidine metabolic process (GO:0046087)3.25882937
74cytidine catabolic process (GO:0006216)3.25882937
75cytidine deamination (GO:0009972)3.25882937
76negative regulation of keratinocyte proliferation (GO:0010839)3.24971215
77cellular response to interferon-alpha (GO:0035457)3.22669337
78L-fucose catabolic process (GO:0042355)3.22392139
79fucose catabolic process (GO:0019317)3.22392139
80L-fucose metabolic process (GO:0042354)3.22392139
81multicellular organismal water homeostasis (GO:0050891)3.22273342
82phosphatidylserine acyl-chain remodeling (GO:0036150)3.21569823
83superoxide anion generation (GO:0042554)3.21454554
84face development (GO:0060324)3.21384620
85translational termination (GO:0006415)3.18293223
86long-chain fatty acid biosynthetic process (GO:0042759)3.15904806
87regulation of natural killer cell activation (GO:0032814)3.15446555
88glucosamine-containing compound catabolic process (GO:1901072)3.14777145
89fucose metabolic process (GO:0006004)3.09588768
90establishment of skin barrier (GO:0061436)3.09322307
91keratinization (GO:0031424)3.05643295
92regulation of metalloenzyme activity (GO:0048552)3.04514445
93amyloid precursor protein catabolic process (GO:0042987)3.03414556
94SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.02991594
95mesonephros development (GO:0001823)3.02316047
96adenosine metabolic process (GO:0046085)3.01633049
97negative regulation of interferon-gamma production (GO:0032689)3.01372780
98regulation of interferon-alpha production (GO:0032647)2.99503634
99protein targeting to ER (GO:0045047)2.98060735
100cotranslational protein targeting to membrane (GO:0006613)2.97390393
101regulation of intracellular pH (GO:0051453)2.91888423
102amino sugar catabolic process (GO:0046348)2.91459954
103bicarbonate transport (GO:0015701)2.90608547
104T-helper cell differentiation (GO:0042093)2.88201432
105CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.88201432
106negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.88099939
107tryptophan catabolic process (GO:0006569)2.87871304
108indole-containing compound catabolic process (GO:0042436)2.87871304
109indolalkylamine catabolic process (GO:0046218)2.87871304
110kynurenine metabolic process (GO:0070189)2.87353787
111epithelial cell differentiation involved in prostate gland development (GO:0060742)2.86939376
112fatty acid elongation (GO:0030497)2.86772890
113iron ion import (GO:0097286)2.86605547
114epithelial cell maturation (GO:0002070)2.83948317
115positive regulation of chemokine biosynthetic process (GO:0045080)2.82302981
116regulation of Cdc42 GTPase activity (GO:0043088)2.81909716
117negative regulation of systemic arterial blood pressure (GO:0003085)2.81604255
118presynaptic membrane organization (GO:0097090)2.81058057
119regulation of somitogenesis (GO:0014807)2.80975254
120cardiac right ventricle morphogenesis (GO:0003215)2.80791788
121establishment of protein localization to endoplasmic reticulum (GO:0072599)2.80136762
122glomerulus development (GO:0032835)2.79894462
123nephron tubule formation (GO:0072079)2.78391775
124protein localization to endoplasmic reticulum (GO:0070972)2.77889947
125cranial nerve structural organization (GO:0021604)2.77249581
126regulation of cellular pH (GO:0030641)2.76787862
127regulation of keratinocyte proliferation (GO:0010837)2.76528260
128intermediate filament organization (GO:0045109)2.76324241
129regulation of apoptotic process involved in morphogenesis (GO:1902337)2.75662722
130regulation of clathrin-mediated endocytosis (GO:2000369)2.74732974
131positive regulation of nitric oxide biosynthetic process (GO:0045429)2.73167809
132negative regulation of transcription by competitive promoter binding (GO:0010944)2.72004846
133regulation of chemokine biosynthetic process (GO:0045073)2.70195636
134positive regulation of type 2 immune response (GO:0002830)2.68874035
135regulation of keratinocyte differentiation (GO:0045616)2.67934872
136phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.67442465
137cornea development in camera-type eye (GO:0061303)2.67359726
138negative regulation of epidermis development (GO:0045683)2.67278799
139germinal center formation (GO:0002467)2.64740195
140regulation of water loss via skin (GO:0033561)2.64337488
141positive regulation of protein homooligomerization (GO:0032464)2.63938310
142regulation of cell proliferation involved in kidney development (GO:1901722)2.63733101
143amyloid precursor protein metabolic process (GO:0042982)2.62565301
144glycoside metabolic process (GO:0016137)2.62381034
145phospholipid scrambling (GO:0017121)2.61587003
146regulation of histone H3-K27 methylation (GO:0061085)2.61062224
147GPI anchor biosynthetic process (GO:0006506)2.60657413
148regulation of ruffle assembly (GO:1900027)2.59944632
149positive regulation of kidney development (GO:0090184)2.59579421
150regulation of immunoglobulin secretion (GO:0051023)2.59519750
151maturation of SSU-rRNA (GO:0030490)2.58305094
152positive regulation of hair follicle development (GO:0051798)2.57875978
153positive regulation of hair cycle (GO:0042635)2.57875978
154sphingoid metabolic process (GO:0046519)2.57563281
155nitric oxide biosynthetic process (GO:0006809)2.55382524
156regulation of nitric oxide biosynthetic process (GO:0045428)2.55084158
157negative regulation of kidney development (GO:0090185)2.54948731
158positive regulation of cAMP-mediated signaling (GO:0043950)2.54909049
159tryptophan metabolic process (GO:0006568)2.53474367
160JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.51100411
161positive regulation of steroid hormone secretion (GO:2000833)2.49305485
162positive regulation of interleukin-1 beta secretion (GO:0050718)2.49237927
163regulation of cytokine secretion involved in immune response (GO:0002739)2.49073491
164calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.47935063
165T cell differentiation involved in immune response (GO:0002292)2.47208309
166alpha-beta T cell differentiation involved in immune response (GO:0002293)2.47208309
167alpha-beta T cell activation involved in immune response (GO:0002287)2.47208309
168positive regulation of monocyte chemotaxis (GO:0090026)2.46777831
169regulation of interleukin-8 secretion (GO:2000482)2.46673505
170bone remodeling (GO:0046849)2.46537255
171inflammatory response to antigenic stimulus (GO:0002437)2.46185112
172viral life cycle (GO:0019058)2.45960673
173embryonic cranial skeleton morphogenesis (GO:0048701)2.45444959
174pharyngeal system development (GO:0060037)2.45119175
175water homeostasis (GO:0030104)2.44277284
176detection of other organism (GO:0098543)2.44206923
177developmental pigmentation (GO:0048066)2.43894126
178regulation of T-helper 1 type immune response (GO:0002825)2.43296391
179positive regulation of cellular amide metabolic process (GO:0034250)2.43053638
180interferon-gamma secretion (GO:0072643)2.42325641
181regulation of podosome assembly (GO:0071801)2.42165942
182protein heterotetramerization (GO:0051290)2.41512594
183regulation of T-helper cell differentiation (GO:0045622)2.41419427
184intermediate filament cytoskeleton organization (GO:0045104)2.40969474
185regulation of epidermis development (GO:0045682)2.37827222
186negative regulation of nitric oxide biosynthetic process (GO:0045019)2.37777046

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_20079471_ChIP-ChIP_T-47D_Human5.22293891
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.08163317
3CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.57489635
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.53614709
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.41351434
6CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.01473921
7FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.92852423
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.82901422
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75397272
10EZH2_22144423_ChIP-Seq_EOC_Human2.65499486
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.58800014
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.58800014
13KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.58800014
14TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.58561982
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.51781586
16AHR_22903824_ChIP-Seq_MCF-7_Human2.35324106
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.33351767
18TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.22743658
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.15089815
20ZNF263_19887448_ChIP-Seq_K562_Human2.14686090
21* GATA3_24758297_ChIP-Seq_MCF-7_Human2.12883768
22IRF1_19129219_ChIP-ChIP_H3396_Human2.10921130
23IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.10774813
24HIF1A_21447827_ChIP-Seq_MCF-7_Human2.01621267
25ELF5_23300383_ChIP-Seq_T47D_Human2.00891198
26PCGF2_27294783_Chip-Seq_ESCs_Mouse2.00354052
27RUNX1_27514584_Chip-Seq_MCF-7_Human1.95238613
28IKZF1_21737484_ChIP-ChIP_HCT116_Human1.95221243
29BMI1_23680149_ChIP-Seq_NPCS_Mouse1.95013432
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.90321367
31ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.85879634
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.85570616
33* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84080670
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.83375541
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83134422
36HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.83089020
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.76221060
38GBX2_23144817_ChIP-Seq_PC3_Human1.75242560
39SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71344937
40SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71344937
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70972955
42ARNT_22903824_ChIP-Seq_MCF-7_Human1.69794431
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.69228901
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.68040501
45EED_16625203_ChIP-ChIP_MESCs_Mouse1.67361737
46LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66244203
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.65155940
48SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.64056802
49FLI1_27457419_Chip-Seq_LIVER_Mouse1.63746229
50* RACK7_27058665_Chip-Seq_MCF-7_Human1.62404957
51TP53_18474530_ChIP-ChIP_U2OS_Human1.56197008
52SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54623103
53GATA4_25053715_ChIP-Seq_YYC3_Human1.52687503
54* IRF8_27001747_Chip-Seq_BMDM_Mouse1.52288810
55SOX2_20726797_ChIP-Seq_SW620_Human1.49720701
56KLF5_25053715_ChIP-Seq_YYC3_Human1.49715208
57PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.49656184
58JARID2_20075857_ChIP-Seq_MESCs_Mouse1.48659721
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.45856907
60EZH2_27294783_Chip-Seq_NPCs_Mouse1.45342301
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.44590597
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44455445
63SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.44304111
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.44209753
65SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.41814746
66TP53_16413492_ChIP-PET_HCT116_Human1.40676461
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.39322358
68TP63_23658742_ChIP-Seq_EP156T_Human1.36284665
69* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.35761096
70CDX2_20551321_ChIP-Seq_CACO-2_Human1.34691582
71BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.33469547
72P63_26484246_Chip-Seq_KERATINOCYTES_Human1.33133438
73GATA6_25053715_ChIP-Seq_YYC3_Human1.32403109
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.31849228
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.30143813
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.26896709
77CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.25005930
78RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24644250
79EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24644250
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24483624
81ESR2_21235772_ChIP-Seq_MCF-7_Human1.24332320
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.23802784
83EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23019385
84* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22614641
85TAF15_26573619_Chip-Seq_HEK293_Human1.21903072
86RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19850238
87POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19444971
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.18329785
89* TP63_22573176_ChIP-Seq_HFKS_Human1.17717347
90STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.17446745
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17220318
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.15243400
93P300_18555785_Chip-Seq_ESCs_Mouse1.14737304
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13829579
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13544315
96GATA1_26923725_Chip-Seq_HPCs_Mouse1.13049796
97* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12753679
98CRX_20693478_ChIP-Seq_RETINA_Mouse1.12048056
99SOX9_24532713_ChIP-Seq_HFSC_Mouse1.11772741
100RXR_22108803_ChIP-Seq_LS180_Human1.11759211
101PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11609667
102HOXB7_26014856_ChIP-Seq_BT474_Human1.11030861
103EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.09838906
104P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09517818
105EGR1_19032775_ChIP-ChIP_M12_Human1.09441617
106P53_22387025_ChIP-Seq_ESCs_Mouse1.08838646
107E2F1_18555785_Chip-Seq_ESCs_Mouse1.08781652
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08181909
109RNF2_27304074_Chip-Seq_ESCs_Mouse1.07731868
110CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07591231
111NANOG_18555785_Chip-Seq_ESCs_Mouse1.07207549
112SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05961057
113SOX2_18555785_Chip-Seq_ESCs_Mouse1.05425392
114NMYC_18555785_Chip-Seq_ESCs_Mouse1.05222566
115FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.04919849
116OCT4_18555785_Chip-Seq_ESCs_Mouse1.04837220
117TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04808886
118NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.04659472
119SUZ12_18555785_Chip-Seq_ESCs_Mouse1.04654860
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.04253821
121ER_23166858_ChIP-Seq_MCF-7_Human1.04208384
122FOXM1_26456572_ChIP-Seq_MCF-7_Human1.02068811
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.01999744
124SMAD3_21741376_ChIP-Seq_HESCs_Human1.01210510
125CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00407354
126TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00353215
127VDR_22108803_ChIP-Seq_LS180_Human1.00338176
128TP53_20018659_ChIP-ChIP_R1E_Mouse1.00329020
129OCT4_21477851_ChIP-Seq_ESCs_Mouse1.00153077
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.99993645
131LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99970994
132MTF2_20144788_ChIP-Seq_MESCs_Mouse0.99848816
133* SCL_19346495_ChIP-Seq_HPC-7_Human0.99773084
134PU1_27457419_Chip-Seq_LIVER_Mouse0.99562335
135STAT3_18555785_Chip-Seq_ESCs_Mouse0.99432951
136* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.99237458
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.98745486
138CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98735535
139GF1_26923725_Chip-Seq_HPCs_Mouse0.98578490
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98456255
141SOX2_27498859_Chip-Seq_STOMACH_Mouse0.96585345
142EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96144739
143STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.91050376
144* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.90522587
145ESR1_15608294_ChIP-ChIP_MCF-7_Human0.90459522
146TDRD3_21172665_ChIP-Seq_MCF-7_Human0.89930252
147STAT1_20625510_ChIP-Seq_HELA_Human0.88084398
148SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.84745225
149GATA1_22025678_ChIP-Seq_K562_Human0.84033056
150GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.83750299
151PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83611642
152P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.82669541
153BCOR_27268052_Chip-Seq_Bcells_Human0.82547815
154FOXA1_25329375_ChIP-Seq_VCAP_Human0.80870321
155FOXA1_27270436_Chip-Seq_PROSTATE_Human0.80870321
156EGR1_23403033_ChIP-Seq_LIVER_Mouse0.79406981
157* GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79356054
158ATF3_27146783_Chip-Seq_COLON_Human0.78967742
159JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78819416
160SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78045773
161KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77905889
162KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.76841738
163OCT4_20526341_ChIP-Seq_ESCs_Human0.75613772
164GATA6_21074721_ChIP-Seq_CACO-2_Human0.75234841
165AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74473237
166SMC4_20622854_ChIP-Seq_HELA_Human0.72108398
167VDR_24787735_ChIP-Seq_THP-1_Human0.71631788
168FOXA1_25552417_ChIP-Seq_VCAP_Human0.71630979
169ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.71262872
170CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.71108427
171PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.70350286
172SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.70179412
173* GATA3_21878914_ChIP-Seq_MCF-7_Human0.70147172
174PPARA_22158963_ChIP-Seq_LIVER_Mouse0.69412685
175E2F1_20622854_ChIP-Seq_HELA_Human0.68475200
176STAT4_19710469_ChIP-ChIP_TH1__Mouse0.68087946
177* ERG_20517297_ChIP-Seq_VCAP_Human0.67434583
178* P53_21459846_ChIP-Seq_SAOS-2_Human0.67114867
179GATA3_26560356_Chip-Seq_TH2_Human0.66691560
180FOXA1_21572438_ChIP-Seq_LNCaP_Human0.65984495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle5.84483154
2MP0002163_abnormal_gland_morphology4.92657985
3MP0002132_abnormal_respiratory_system4.64592447
4MP0002277_abnormal_respiratory_mucosa3.92686350
5MP0004885_abnormal_endolymph3.86614304
6MP0010678_abnormal_skin_adnexa3.69290811
7MP0005379_endocrine/exocrine_gland_phen3.59506981
8MP0004264_abnormal_extraembryonic_tissu3.41788769
9MP0003300_gastrointestinal_ulcer3.29060075
10MP0003136_yellow_coat_color3.12663943
11MP0009379_abnormal_foot_pigmentation3.04729317
12MP0000566_synostosis2.92882338
13MP0004381_abnormal_hair_follicle2.76966107
14MP0000613_abnormal_salivary_gland2.75753214
15MP0001485_abnormal_pinna_reflex2.74918468
16MP0003303_peritoneal_inflammation2.69796198
17MP0006292_abnormal_olfactory_placode2.66983914
18MP0000427_abnormal_hair_cycle2.66416113
19MP0001188_hyperpigmentation2.59504624
20MP0004947_skin_inflammation2.49015224
21MP0005409_darkened_coat_color2.43171859
22MP0001346_abnormal_lacrimal_gland2.41719987
23MP0002254_reproductive_system_inflammat2.30604661
24MP0005174_abnormal_tail_pigmentation2.25426392
25MP0002009_preneoplasia2.17938123
26MP0002098_abnormal_vibrissa_morphology2.10471966
27MP0008789_abnormal_olfactory_epithelium2.09494229
28MP0003941_abnormal_skin_development2.05367777
29MP0003191_abnormal_cellular_cholesterol1.92504929
30MP0000462_abnormal_digestive_system1.90351636
31MP0005408_hypopigmentation1.90106516
32MP0004742_abnormal_vestibular_system1.88838635
33MP0002796_impaired_skin_barrier1.75150908
34MP0008004_abnormal_stomach_pH1.71690613
35MP0005451_abnormal_body_composition1.65249461
36MP0003763_abnormal_thymus_physiology1.63311167
37MP0005248_abnormal_Harderian_gland1.57492424
38MP0006082_CNS_inflammation1.55932023
39MP0002877_abnormal_melanocyte_morpholog1.51790037
40MP0005394_taste/olfaction_phenotype1.51559357
41MP0005499_abnormal_olfactory_system1.51559357
42MP0009931_abnormal_skin_appearance1.46578479
43MP0004510_myositis1.44854883
44MP0000579_abnormal_nail_morphology1.44842287
45MP0001177_atelectasis1.44048439
46MP0001984_abnormal_olfaction1.43346028
47MP0002148_abnormal_hypersensitivity_rea1.42382992
48MP0008872_abnormal_physiological_respon1.41087844
49MP0003724_increased_susceptibility_to1.32833526
50MP0000372_irregular_coat_pigmentation1.32364423
51MP0000762_abnormal_tongue_morphology1.31639835
52MP0000678_abnormal_parathyroid_gland1.30611654
53MP0003806_abnormal_nucleotide_metabolis1.30252270
54MP0000367_abnormal_coat/_hair1.29864578
55MP0005671_abnormal_response_to1.29081653
56MP0003195_calcinosis1.28166334
57MP0005058_abnormal_lysosome_morphology1.26002126
58MP0005171_absent_coat_pigmentation1.24414828
59MP0000049_abnormal_middle_ear1.22670000
60MP0001986_abnormal_taste_sensitivity1.21216935
61MP0010030_abnormal_orbit_morphology1.20840595
62MP0002177_abnormal_outer_ear1.17994998
63MP0002233_abnormal_nose_morphology1.13448781
64MP0000383_abnormal_hair_follicle1.13327763
65MP0000627_abnormal_mammary_gland1.11868212
66MP0000681_abnormal_thyroid_gland1.11854668
67MP0009780_abnormal_chondrocyte_physiolo1.09571608
68MP0001663_abnormal_digestive_system1.09085714
69MP0002938_white_spotting1.08972709
70MP0001270_distended_abdomen1.08179710
71MP0001191_abnormal_skin_condition1.07675511
72MP0005647_abnormal_sex_gland1.03720544
73MP0005220_abnormal_exocrine_pancreas1.02529932
74MP0001963_abnormal_hearing_physiology1.00767615
75MP0001835_abnormal_antigen_presentation0.99686288
76MP0003638_abnormal_response/metabolism_0.99202737
77MP0002095_abnormal_skin_pigmentation0.97661593
78MP0003878_abnormal_ear_physiology0.96477489
79MP0005377_hearing/vestibular/ear_phenot0.96477489
80MP0001873_stomach_inflammation0.95819781
81MP0002405_respiratory_system_inflammati0.94998801
82MP0001881_abnormal_mammary_gland0.94609477
83MP0002332_abnormal_exercise_endurance0.94550281
84MP0005501_abnormal_skin_physiology0.93725943
85MP0003718_maternal_effect0.93622972
86MP0003880_abnormal_central_pattern0.92915376
87MP0001919_abnormal_reproductive_system0.92262780
88MP0005388_respiratory_system_phenotype0.92073170
89MP0002133_abnormal_respiratory_system0.92073170
90MP0003938_abnormal_ear_development0.92021151
91MP0002089_abnormal_postnatal_growth/wei0.91780437
92MP0002736_abnormal_nociception_after0.91355762
93MP0000026_abnormal_inner_ear0.90928464
94MP0003453_abnormal_keratinocyte_physiol0.90346251
95MP0004147_increased_porphyrin_level0.88600823
96MP0001664_abnormal_digestion0.88175972
97MP0000647_abnormal_sebaceous_gland0.87645537
98MP0004043_abnormal_pH_regulation0.86532343
99MP0005381_digestive/alimentary_phenotyp0.85506299
100MP0001851_eye_inflammation0.84851335
101MP0005083_abnormal_biliary_tract0.84232742
102MP0003866_abnormal_defecation0.83537313
103MP0001186_pigmentation_phenotype0.81956423
104MP0000467_abnormal_esophagus_morphology0.81451182
105MP0009785_altered_susceptibility_to0.80951916
106MP0010352_gastrointestinal_tract_polyps0.80769119
107MP0002249_abnormal_larynx_morphology0.79834033
108MP0005025_abnormal_response_to0.79742225
109MP0009764_decreased_sensitivity_to0.79443047
110MP0001533_abnormal_skeleton_physiology0.79183370
111MP0001216_abnormal_epidermal_layer0.78735120
112MP0003436_decreased_susceptibility_to0.77843102
113MP0001243_abnormal_dermal_layer0.77230972
114MP0010386_abnormal_urinary_bladder0.76130312
115MP0002166_altered_tumor_susceptibility0.75160301
116MP0002419_abnormal_innate_immunity0.74883898
117MP0002723_abnormal_immune_serum0.74224200
118MP0004782_abnormal_surfactant_physiolog0.73626608
119MP0005646_abnormal_pituitary_gland0.72396312
120MP0010155_abnormal_intestine_physiology0.71070441
121MP0003183_abnormal_peptide_metabolism0.70352463
122MP0000490_abnormal_crypts_of0.70184713
123MP0003075_altered_response_to0.69556720
124MP0002160_abnormal_reproductive_system0.69523671
125MP0005000_abnormal_immune_tolerance0.67836034
126MP0000465_gastrointestinal_hemorrhage0.67742271
127MP0002452_abnormal_antigen_presenting0.67515188
128MP0000377_abnormal_hair_follicle0.67058657
129MP0005387_immune_system_phenotype0.66995656
130MP0001790_abnormal_immune_system0.66995656
131MP0005075_abnormal_melanosome_morpholog0.66672348
132MP0001800_abnormal_humoral_immune0.66311571
133MP0002006_tumorigenesis0.66243959
134MP0010771_integument_phenotype0.64593245
135MP0005310_abnormal_salivary_gland0.63748297
136MP0005275_abnormal_skin_tensile0.61924309
137MP0001845_abnormal_inflammatory_respons0.61728876
138MP0000371_diluted_coat_color0.61535350
139MP0002060_abnormal_skin_morphology0.61447535
140MP0001764_abnormal_homeostasis0.61359782
141MP0003011_delayed_dark_adaptation0.59667131
142MP0001968_abnormal_touch/_nociception0.59568370
143MP0001765_abnormal_ion_homeostasis0.59221809
144MP0003705_abnormal_hypodermis_morpholog0.54817240
145MP0000015_abnormal_ear_pigmentation0.54356052
146MP0009333_abnormal_splenocyte_physiolog0.53650497
147MP0005636_abnormal_mineral_homeostasis0.52047066
148MP0009765_abnormal_xenobiotic_induced0.51970781
149MP0008469_abnormal_protein_level0.50324136
150MP0003936_abnormal_reproductive_system0.45534394
151MP0002653_abnormal_ependyma_morphology0.44693863
152MP0005367_renal/urinary_system_phenotyp0.43449064
153MP0000516_abnormal_urinary_system0.43449064
154MP0003172_abnormal_lysosome_physiology0.43355714
155MP0003448_altered_tumor_morphology0.43174070
156MP0004019_abnormal_vitamin_homeostasis0.42952779

Predicted human phenotypes

RankGene SetZ-score
1Morphological abnormality of the inner ear (HP:0011390)9.23034520
2Abnormality of nail color (HP:0100643)7.80401508
3Abnormality of chloride homeostasis (HP:0011422)6.43963053
4Ileus (HP:0002595)6.18791066
5Erythroderma (HP:0001019)5.71031216
6Palmoplantar hyperkeratosis (HP:0000972)5.60423443
7Palmar hyperkeratosis (HP:0010765)5.32024409
8Male infertility (HP:0003251)5.16154049
9Hyperactive renin-angiotensin system (HP:0000841)4.91246759
10Rectal prolapse (HP:0002035)4.69667655
11Pili torti (HP:0003777)4.61977008
12Erythema (HP:0010783)4.53727241
13Abnormality of the right ventricle (HP:0001707)4.51150114
14Azoospermia (HP:0000027)4.40365303
15Thick nail (HP:0001805)4.37262353
16Alopecia of scalp (HP:0002293)4.13202686
17Conjunctival hamartoma (HP:0100780)4.05122401
18Curly hair (HP:0002212)4.03679300
19Gangrene (HP:0100758)3.91101068
20Onycholysis (HP:0001806)3.60698116
21Lip pit (HP:0100267)3.59350489
22Hypothermia (HP:0002045)3.53645554
23Hyperaldosteronism (HP:0000859)3.49484477
24Hypohidrosis (HP:0000966)3.47528818
25Abnormal hair laboratory examination (HP:0003328)3.46461421
26Hyperparathyroidism (HP:0000843)3.42199452
27Oral leukoplakia (HP:0002745)3.41606054
28Abnormal spermatogenesis (HP:0008669)3.30154411
29Concave nail (HP:0001598)3.28787929
30Renal salt wasting (HP:0000127)3.15993431
31Osteomalacia (HP:0002749)3.00805473
32Hamartoma of the eye (HP:0010568)2.99034613
33Abnormality of liposaccharide metabolism (HP:0010968)2.92080842
34Abnormality of glycosphingolipid metabolism (HP:0004343)2.92080842
35Abnormality of glycolipid metabolism (HP:0010969)2.92080842
36Hyponatremia (HP:0002902)2.90566319
37Decreased circulating renin level (HP:0003351)2.88186538
38Palmoplantar keratoderma (HP:0000982)2.85284355
39Stomatitis (HP:0010280)2.82648428
40Hypokalemic alkalosis (HP:0001949)2.78078843
41Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.77556696
42Type I transferrin isoform profile (HP:0003642)2.75147374
43Furrowed tongue (HP:0000221)2.68372570
44Abnormality of the axillary hair (HP:0100134)2.64566061
45Abnormality of secondary sexual hair (HP:0009888)2.64566061
46Nail dystrophy (HP:0008404)2.62646436
47Parakeratosis (HP:0001036)2.62646380
48Vertigo (HP:0002321)2.61897190
49Chronic bronchitis (HP:0004469)2.58403681
50Increased cerebral lipofuscin (HP:0011813)2.57355230
51Pustule (HP:0200039)2.52507857
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.50675041
53Congenital ichthyosiform erythroderma (HP:0007431)2.50312965
54Hyperkalemia (HP:0002153)2.47614840
55Abnormal blistering of the skin (HP:0008066)2.46196778
56Abnormality of renin-angiotensin system (HP:0000847)2.45804543
57Nonprogressive disorder (HP:0003680)2.44883685
58Hypercalciuria (HP:0002150)2.44560870
59Exocrine pancreatic insufficiency (HP:0001738)2.42898123
60Keratoconjunctivitis sicca (HP:0001097)2.42212798
61Severe visual impairment (HP:0001141)2.42012532
62Submucous cleft hard palate (HP:0000176)2.39847621
63Goiter (HP:0000853)2.39813250
64Reduced antithrombin III activity (HP:0001976)2.39780089
65Eczematoid dermatitis (HP:0000976)2.38870646
66Stenosis of the external auditory canal (HP:0000402)2.37738146
67Hypergammaglobulinemia (HP:0010702)2.36280420
68Abnormal hemoglobin (HP:0011902)2.35156444
69Congenital, generalized hypertrichosis (HP:0004540)2.35127495
70Stomach cancer (HP:0012126)2.34766614
71Slow-growing hair (HP:0002217)2.32945061
72Abnormality of hair growth rate (HP:0011363)2.32945061
73Loss of speech (HP:0002371)2.32275875
74Dehydration (HP:0001944)2.31595746
75Keratoconjunctivitis (HP:0001096)2.30589981
76Abnormality of sodium homeostasis (HP:0010931)2.25760381
77Absent rod-and cone-mediated responses on ERG (HP:0007688)2.20693151
78Orchitis (HP:0100796)2.20458880
79Absent eyelashes (HP:0000561)2.20412971
80Bronchiectasis (HP:0002110)2.19920761
81Popliteal pterygium (HP:0009756)2.17356954
82Dysostosis multiplex (HP:0000943)2.14610754
83Aplasia/Hypoplasia of the sacrum (HP:0008517)2.11012831
84Metabolic alkalosis (HP:0200114)2.10503718
85Septate vagina (HP:0001153)2.10471537
86Split foot (HP:0001839)2.10454828
87Recurrent pneumonia (HP:0006532)2.09185021
88Interstitial pulmonary disease (HP:0006530)2.08909370
89Woolly hair (HP:0002224)2.08181914
90Vacuolated lymphocytes (HP:0001922)2.07201475
91Aplasia/hypoplasia of the uterus (HP:0008684)2.06085882
92Abnormality of cells of the erythroid lineage (HP:0012130)2.06006488
93Reticulocytopenia (HP:0001896)2.04993724
94Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.03581840
95Renal tubular dysfunction (HP:0000124)2.02156737
96Thyroid-stimulating hormone excess (HP:0002925)2.01910219
97Abnormality of cochlea (HP:0000375)12.2706653
98Blepharitis (HP:0000498)1.97465888
99Abnormal number of erythroid precursors (HP:0012131)1.97396631
100Hypoplastic labia majora (HP:0000059)1.95933000
101Abnormality of renal resorption (HP:0011038)1.94996094
102Pulmonary fibrosis (HP:0002206)1.93660398
103Hypotrichosis (HP:0001006)1.91687149
104Tracheal stenosis (HP:0002777)1.91179216
105Gastrointestinal dysmotility (HP:0002579)1.90633133
106Nasolacrimal duct obstruction (HP:0000579)1.89259454
107Right ventricular cardiomyopathy (HP:0011663)1.87748327
108Increased IgE level (HP:0003212)1.87638862
109Abnormality of polysaccharide metabolism (HP:0011012)1.86699219
110Abnormality of glycosaminoglycan metabolism (HP:0004371)1.86699219
111Abnormality of mucopolysaccharide metabolism (HP:0011020)1.86699219
112Advanced eruption of teeth (HP:0006288)1.85737397
113Cone-rod dystrophy (HP:0000548)1.85131581
114Abnormality of the salivary glands (HP:0010286)1.84456897
115Tinnitus (HP:0000360)1.84059010
116Sparse lateral eyebrow (HP:0005338)1.83538192
117Sparse scalp hair (HP:0002209)1.81993607
118Hypoplasia of the uterus (HP:0000013)1.81661758
119Alkalosis (HP:0001948)1.80823643
120Adrenal hypoplasia (HP:0000835)1.80791190
121Natal tooth (HP:0000695)1.79888790
122Ectropion (HP:0000656)1.79662467
123Distal lower limb muscle weakness (HP:0009053)1.79448614
124Follicular hyperkeratosis (HP:0007502)1.77067694
125Recurrent bacterial skin infections (HP:0005406)1.76952226
126Absent hair (HP:0002298)1.76490787
127Adrenal overactivity (HP:0002717)1.75115328
128Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73401028
129Urinary glycosaminoglycan excretion (HP:0003541)1.73308982
130Mucopolysacchariduria (HP:0008155)1.73308982
131Dry hair (HP:0011359)1.72195300
132Abnormality of the labia majora (HP:0012881)1.71791128
133Sex reversal (HP:0012245)1.71493139
134Abnormal sex determination (HP:0012244)1.71493139
135Myositis (HP:0100614)1.71370352
136Renal Fanconi syndrome (HP:0001994)1.69591229
137Fragile nails (HP:0001808)1.69365140
138Chronic otitis media (HP:0000389)1.68700123
139Renal cortical cysts (HP:0000803)1.67761520
140Brittle hair (HP:0002299)1.67072212
141Paralysis (HP:0003470)1.66401630
142Hyperphosphaturia (HP:0003109)1.65312492
143Widely spaced teeth (HP:0000687)1.65210341
144Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.64723270
145Abnormality of the dental root (HP:0006486)1.62933075
146Taurodontia (HP:0000679)1.62933075
147Abnormality of permanent molar morphology (HP:0011071)1.62933075
148Sparse eyelashes (HP:0000653)1.62656281
149Abnormality of dental color (HP:0011073)1.62247098
150Nephropathy (HP:0000112)1.61396197
151Oligodontia (HP:0000677)1.61142242
152Patchy hypopigmentation of hair (HP:0011365)1.61076044
153Conical tooth (HP:0000698)1.59917244
154Generalized aminoaciduria (HP:0002909)1.59287456
155Amelogenesis imperfecta (HP:0000705)1.58963098
156Decreased electroretinogram (ERG) amplitude (HP:0000654)1.58521540
157Pruritus (HP:0000989)1.57411806
158Dry skin (HP:0000958)1.57397502
159Male pseudohermaphroditism (HP:0000037)1.57370435
160Cortical visual impairment (HP:0100704)1.57362392
161Syncope (HP:0001279)1.56650586
162Melanocytic nevus (HP:0000995)1.55363811
163Plantar hyperkeratosis (HP:0007556)1.54310951
164Retrobulbar optic neuritis (HP:0100654)1.54123728
165Optic neuritis (HP:0100653)1.54123728
166Urticaria (HP:0001025)1.52575278
167Cupped ear (HP:0000378)1.51769568
168Down-sloping shoulders (HP:0200021)1.51080793
169White forelock (HP:0002211)1.50882125
170Cheilitis (HP:0100825)1.50823354
171Abnormality of the dental pulp (HP:0006479)1.50653645
172Corneal erosion (HP:0200020)1.50581768
173Sleep apnea (HP:0010535)1.50483611
174Abnormality of the distal phalanges of the toes (HP:0010182)1.48382338
175Fine hair (HP:0002213)1.47680782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA25.63493375
2PRKG23.40476291
3TNIK2.93073306
4CASK2.38103249
5RIPK12.29418131
6LATS12.23409324
7LMTK211.8743859
8TAOK21.96896224
9NLK1.96668926
10NME21.88195269
11MST41.83523735
12PKN21.78996048
13TAOK11.77312240
14STK391.76452103
15MKNK21.72280312
16SRPK11.71058730
17EPHA31.70880931
18MUSK1.67450591
19EIF2AK11.66063875
20CHUK1.57497806
21TESK11.56718334
22IRAK11.55281849
23TBK11.47681136
24TLK11.42071926
25MAP4K21.42043362
26STK38L1.40686521
27NME11.40181978
28TXK1.30060445
29HIPK21.29725461
30IRAK41.25347777
31TRIB31.25345900
32SIK31.24655638
33FRK1.23079980
34BLK1.22275140
35TNK21.19226207
36BMPR21.12108099
37IRAK21.09052251
38STK161.08489407
39MKNK11.05934228
40LATS21.05536363
41RPS6KB21.00903648
42PRKCI1.00025341
43NEK60.99820851
44MAPK150.99454464
45MST1R0.97838326
46MAP3K20.96003114
47BMPR1B0.93700440
48ADRBK20.92778629
49EPHB10.91062862
50FER0.90962271
51IRAK30.90881529
52MAP3K30.88842943
53EIF2AK20.88452259
54GRK60.86770167
55EIF2AK30.86686681
56CDK190.84816264
57MAPKAPK50.81397290
58OXSR10.81017290
59JAK20.80666826
60ERBB30.76918186
61TEC0.75598385
62ZAK0.73452556
63CLK10.72239967
64JAK30.70790178
65MAP3K140.67558865
66DAPK20.66744297
67PRKD20.66408657
68PRPF4B0.65895264
69MAP2K20.65130682
70PKN10.63977569
71TAOK30.63663458
72TRPM70.63636291
73IKBKB0.60681794
74GRK70.59488196
75DYRK30.59286211
76PAK40.59050970
77STK380.58641330
78TGFBR10.57557791
79GRK10.57061400
80YES10.56702417
81ERBB20.55253297
82PRKCE0.54331537
83FES0.53096154
84ROCK10.52346518
85RIPK40.51949990
86IKBKE0.51524732
87TRIM280.50659316
88CDC42BPA0.50569795
89PRKAA20.50526001
90CAMK10.50354617
91ABL10.48896963
92TGFBR20.48792859
93BCR0.48706795
94MAP3K120.48301784
95ACVR1B0.45762826
96MAP2K10.45608596
97ABL20.44995025
98TYK20.44975856
99ADRBK10.44373754
100CSNK1A1L0.44058567
101PDK20.41901386
102CSNK1A10.41729996
103MAP3K10.40714201
104MAP3K50.39872779
105NUAK10.39427634
106CSNK1G30.38596389
107CDK80.38234874
108PIM20.37715131
109ILK0.37138882
110FGR0.36678267
111UHMK10.36090821
112DYRK20.35995783
113BTK0.35933602
114WNK30.34143557
115EPHB20.34049828
116MAP3K60.33960684
117STK30.33939805
118CAMK2B0.32807313
119CDK30.32349131
120KIT0.32211674
121MAPKAPK30.31440275
122VRK10.30496199
123PIK3CG0.30258878
124RPS6KA40.29669416
125CAMK2G0.29371085
126MET0.29094950
127PBK0.28776144
128MAP4K10.27976875
129CDK60.27485105
130PRKCD0.27138635
131MYLK0.26679152
132TAF10.26207004
133EGFR0.26121800
134MATK0.25358196
135CSF1R0.24598545
136PRKD10.23884954
137SIK10.23796488
138LYN0.23716271
139MAPKAPK20.23697176
140PRKG10.23612436
141MAP2K60.23564840
142RPS6KA50.22628954
143SGK20.21723575
144PIK3CA0.19760924
145HCK0.19430231
146DYRK1A0.19259910
147MAPK130.19164587
148ZAP700.17304923

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.79452158
2Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.98933199
3Caffeine metabolism_Homo sapiens_hsa002322.56976692
4Sulfur metabolism_Homo sapiens_hsa009202.54605596
5Vibrio cholerae infection_Homo sapiens_hsa051102.46472902
6Other glycan degradation_Homo sapiens_hsa005112.39778692
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.33581884
8Oxidative phosphorylation_Homo sapiens_hsa001902.32504941
9Lysosome_Homo sapiens_hsa041422.21734376
10Protein export_Homo sapiens_hsa030602.18943711
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.16488916
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05901392
13Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.00441643
14TNF signaling pathway_Homo sapiens_hsa046681.99959596
15Mineral absorption_Homo sapiens_hsa049781.81637281
16Sulfur relay system_Homo sapiens_hsa041221.76127055
17Graft-versus-host disease_Homo sapiens_hsa053321.71970711
18Taste transduction_Homo sapiens_hsa047421.68657008
19ABC transporters_Homo sapiens_hsa020101.66781870
20Arachidonic acid metabolism_Homo sapiens_hsa005901.61801537
21Chemical carcinogenesis_Homo sapiens_hsa052041.56669589
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.55935679
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.55219775
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.49126316
25Legionellosis_Homo sapiens_hsa051341.46025060
26Tuberculosis_Homo sapiens_hsa051521.44480843
27Staphylococcus aureus infection_Homo sapiens_hsa051501.40384264
28Rheumatoid arthritis_Homo sapiens_hsa053231.39745676
29Ovarian steroidogenesis_Homo sapiens_hsa049131.31569167
30Pentose and glucuronate interconversions_Homo sapiens_hsa000401.29429387
31Collecting duct acid secretion_Homo sapiens_hsa049661.28855223
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.27888660
33Sphingolipid metabolism_Homo sapiens_hsa006001.24818774
34Toxoplasmosis_Homo sapiens_hsa051451.24335332
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.24296715
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22263581
37Phototransduction_Homo sapiens_hsa047441.22249930
38Osteoclast differentiation_Homo sapiens_hsa043801.22198111
39African trypanosomiasis_Homo sapiens_hsa051431.16599218
40Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.13442774
41Alzheimers disease_Homo sapiens_hsa050101.13361042
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12615324
43Parkinsons disease_Homo sapiens_hsa050121.11988768
44Hematopoietic cell lineage_Homo sapiens_hsa046401.11331920
45Prolactin signaling pathway_Homo sapiens_hsa049171.10159278
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.08298524
47Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.08038766
48Ether lipid metabolism_Homo sapiens_hsa005651.05880266
49Leishmaniasis_Homo sapiens_hsa051401.04657252
50Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.03413281
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.02365965
52Herpes simplex infection_Homo sapiens_hsa051681.00275891
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99587958
54Type I diabetes mellitus_Homo sapiens_hsa049400.99544181
55Cyanoamino acid metabolism_Homo sapiens_hsa004600.97305904
56VEGF signaling pathway_Homo sapiens_hsa043700.93882602
57Gastric acid secretion_Homo sapiens_hsa049710.91949142
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90953006
59Tryptophan metabolism_Homo sapiens_hsa003800.90698418
60Autoimmune thyroid disease_Homo sapiens_hsa053200.89891393
61Salmonella infection_Homo sapiens_hsa051320.88751798
62Malaria_Homo sapiens_hsa051440.87287892
63Steroid biosynthesis_Homo sapiens_hsa001000.87164392
64Allograft rejection_Homo sapiens_hsa053300.86031527
65Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.85194259
66Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84946444
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.83018261
68Linoleic acid metabolism_Homo sapiens_hsa005910.82767693
69Primary immunodeficiency_Homo sapiens_hsa053400.82631536
70Fatty acid elongation_Homo sapiens_hsa000620.82602332
71Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.80705335
72Dorso-ventral axis formation_Homo sapiens_hsa043200.79272288
73NF-kappa B signaling pathway_Homo sapiens_hsa040640.78193886
74alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77062970
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.76769497
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.76140802
77Huntingtons disease_Homo sapiens_hsa050160.75959259
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75734523
79Olfactory transduction_Homo sapiens_hsa047400.75213999
80Acute myeloid leukemia_Homo sapiens_hsa052210.73872970
81Measles_Homo sapiens_hsa051620.73722184
82Retinol metabolism_Homo sapiens_hsa008300.73690173
83Basal cell carcinoma_Homo sapiens_hsa052170.69556394
84Histidine metabolism_Homo sapiens_hsa003400.67111780
85Pancreatic secretion_Homo sapiens_hsa049720.66547510
86Glutathione metabolism_Homo sapiens_hsa004800.64885710
87Leukocyte transendothelial migration_Homo sapiens_hsa046700.63562258
88Chemokine signaling pathway_Homo sapiens_hsa040620.63101639
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60568917
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.60279947
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59919974
92Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59312966
93Bladder cancer_Homo sapiens_hsa052190.58839559
94T cell receptor signaling pathway_Homo sapiens_hsa046600.58719462
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58501800
96Renin secretion_Homo sapiens_hsa049240.56447497
97Jak-STAT signaling pathway_Homo sapiens_hsa046300.53751946
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.52566902
99Endocytosis_Homo sapiens_hsa041440.51752609
100Hepatitis B_Homo sapiens_hsa051610.48489512
101beta-Alanine metabolism_Homo sapiens_hsa004100.47484804
102Notch signaling pathway_Homo sapiens_hsa043300.47231531
103Pertussis_Homo sapiens_hsa051330.47152984
104Wnt signaling pathway_Homo sapiens_hsa043100.46798328
105RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45931385
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45787211
107Adipocytokine signaling pathway_Homo sapiens_hsa049200.45472229
108Thyroid cancer_Homo sapiens_hsa052160.45213433
109Serotonergic synapse_Homo sapiens_hsa047260.44377527
110Phagosome_Homo sapiens_hsa041450.41570805
111Amoebiasis_Homo sapiens_hsa051460.41138274
112Glycosaminoglycan degradation_Homo sapiens_hsa005310.40725125
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.40524798
114Fanconi anemia pathway_Homo sapiens_hsa034600.39844146
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.39618866
116ECM-receptor interaction_Homo sapiens_hsa045120.39429960
117Platelet activation_Homo sapiens_hsa046110.39155163
118RNA polymerase_Homo sapiens_hsa030200.39015322
119Shigellosis_Homo sapiens_hsa051310.38369294
120Epstein-Barr virus infection_Homo sapiens_hsa051690.37839751
121Hepatitis C_Homo sapiens_hsa051600.36460796
122Choline metabolism in cancer_Homo sapiens_hsa052310.35947629
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.35415418
124Apoptosis_Homo sapiens_hsa042100.35069566
125* Influenza A_Homo sapiens_hsa051640.34495904
126Proteasome_Homo sapiens_hsa030500.34142914
127Asthma_Homo sapiens_hsa053100.33746817
128Pathways in cancer_Homo sapiens_hsa052000.33581855
129Viral myocarditis_Homo sapiens_hsa054160.33391730
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33225012
131Metabolic pathways_Homo sapiens_hsa011000.32910204
132Regulation of autophagy_Homo sapiens_hsa041400.32373177
133Long-term depression_Homo sapiens_hsa047300.32050238
134Melanoma_Homo sapiens_hsa052180.31943501
135Drug metabolism - other enzymes_Homo sapiens_hsa009830.31294132
136Insulin resistance_Homo sapiens_hsa049310.30559169
137Basal transcription factors_Homo sapiens_hsa030220.30375723
138Purine metabolism_Homo sapiens_hsa002300.29939559
139Pyrimidine metabolism_Homo sapiens_hsa002400.29334773
140Folate biosynthesis_Homo sapiens_hsa007900.29221597
141Tight junction_Homo sapiens_hsa045300.27120461
142Vitamin digestion and absorption_Homo sapiens_hsa049770.25509056
143GnRH signaling pathway_Homo sapiens_hsa049120.22422264
144Ras signaling pathway_Homo sapiens_hsa040140.22149945
145mTOR signaling pathway_Homo sapiens_hsa041500.20936961
146Antigen processing and presentation_Homo sapiens_hsa046120.20447970

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