TMPRSS11D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a trypsin-like serine protease released from the submucosal serous glands onto mucous membrane. It is a type II integral membrane protein and has 29-38% identity in the sequence of the catalytic region with human hepsin, enteropeptidase, acrosin, and mast cell tryptase. The noncatalytic region has little similarity to other known proteins. This protein may play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organismal water homeostasis (GO:0050891)9.09768898
2bundle of His cell to Purkinje myocyte communication (GO:0086069)8.49911850
3epidermis development (GO:0008544)8.15278719
4establishment of tissue polarity (GO:0007164)7.68593382
5establishment of planar polarity (GO:0001736)7.68593382
6keratinocyte proliferation (GO:0043616)7.57033528
7water homeostasis (GO:0030104)7.56563211
8long-chain fatty acid biosynthetic process (GO:0042759)7.26411863
9ectoderm development (GO:0007398)6.19220523
10molting cycle (GO:0042303)5.18551009
11hair cycle (GO:0042633)5.18551009
12linoleic acid metabolic process (GO:0043651)5.06374936
13eyelid development in camera-type eye (GO:0061029)4.78640821
14lateral sprouting from an epithelium (GO:0060601)4.62680759
15regulation of natural killer cell differentiation (GO:0032823)4.56249316
16negative regulation of interferon-gamma production (GO:0032689)4.53080481
17skin morphogenesis (GO:0043589)4.48995438
18hemidesmosome assembly (GO:0031581)4.44003291
19polarized epithelial cell differentiation (GO:0030859)4.43107520
20gap junction assembly (GO:0016264)4.39754240
21superoxide anion generation (GO:0042554)4.37603324
22intermediate filament organization (GO:0045109)4.29662915
23planar cell polarity pathway involved in neural tube closure (GO:0090179)4.28332951
24sequestering of metal ion (GO:0051238)4.26067344
25intermediate filament cytoskeleton organization (GO:0045104)4.22606092
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.15653592
27intermediate filament-based process (GO:0045103)4.07081106
28surfactant homeostasis (GO:0043129)4.01161574
29transepithelial transport (GO:0070633)3.95369998
30epithelium development (GO:0060429)3.93242996
31ventricular cardiac muscle cell action potential (GO:0086005)3.86874368
32keratinocyte development (GO:0003334)3.81126537
33regulation of ruffle assembly (GO:1900027)3.78186336
34apical protein localization (GO:0045176)3.77783832
35regulation of timing of cell differentiation (GO:0048505)3.74091756
36cell differentiation involved in metanephros development (GO:0072202)3.73945231
37hair cell differentiation (GO:0035315)3.73503981
38negative regulation of keratinocyte proliferation (GO:0010839)3.68624443
39epithelial cell differentiation involved in prostate gland development (GO:0060742)3.68074911
40mesenchymal cell differentiation involved in kidney development (GO:0072161)3.63478949
41mesenchymal cell differentiation involved in renal system development (GO:2001012)3.63478949
42phosphatidylserine acyl-chain remodeling (GO:0036150)3.51355483
43negative regulation of interleukin-17 production (GO:0032700)3.45137619
44regulation of activation of Janus kinase activity (GO:0010533)3.43771850
45detection of other organism (GO:0098543)3.42361313
46regulation of heart rate by cardiac conduction (GO:0086091)3.39081569
47chemical homeostasis within a tissue (GO:0048875)3.38654923
48hair follicle morphogenesis (GO:0031069)3.38384830
49phosphatidylinositol acyl-chain remodeling (GO:0036149)3.30663071
50regulation of development, heterochronic (GO:0040034)3.28359580
51epithelial cell differentiation (GO:0030855)3.27972412
52negative regulation of mast cell activation (GO:0033004)3.23490451
53G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.22487935
54regulation of male gonad development (GO:2000018)3.21175155
55intestinal epithelial cell development (GO:0060576)3.20738842
56detection of bacterium (GO:0016045)3.16719378
57Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.12174194
58asymmetric protein localization (GO:0008105)3.11468993
59ganglion development (GO:0061548)3.10175875
60regulation of establishment of planar polarity (GO:0090175)3.09506704
61adenosine metabolic process (GO:0046085)3.08697362
62positive regulation of p38MAPK cascade (GO:1900745)3.07997191
63regulation of interleukin-8 secretion (GO:2000482)3.03551458
64female gonad development (GO:0008585)3.01624414
65phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.00320730
66keratinization (GO:0031424)24.4295372
67G-protein coupled receptor internalization (GO:0002031)2.99390507
68sympathetic nervous system development (GO:0048485)2.97226709
69regulation of T cell chemotaxis (GO:0010819)2.96844004
70positive regulation of T cell chemotaxis (GO:0010820)2.96844004
71dendritic cell chemotaxis (GO:0002407)2.96601031
72cell communication involved in cardiac conduction (GO:0086065)2.95776028
73lymphoid progenitor cell differentiation (GO:0002320)2.95449474
74DNA ligation (GO:0006266)2.90930399
75positive regulation of epidermal cell differentiation (GO:0045606)2.84978665
76positive regulation of epidermis development (GO:0045684)2.84948518
77regulation of keratinocyte differentiation (GO:0045616)2.82520665
78cerebral cortex radially oriented cell migration (GO:0021799)2.82305661
79limb bud formation (GO:0060174)2.81184467
80positive regulation of vesicle fusion (GO:0031340)2.78597928
81regulation of monocyte chemotaxis (GO:0090025)2.77464139
82cardiac conduction (GO:0061337)2.75020882
83ceramide biosynthetic process (GO:0046513)2.73395711
84response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.73242646
85centriole assembly (GO:0098534)2.70232530
86dendritic cell migration (GO:0036336)2.69569238
87microtubule depolymerization (GO:0007019)2.68990310
88dentate gyrus development (GO:0021542)2.67782236
89genitalia morphogenesis (GO:0035112)2.67425090
90adenine nucleotide transport (GO:0051503)2.66508113
91hypotonic response (GO:0006971)2.66039985
92positive regulation of cellular amide metabolic process (GO:0034250)2.65726938
93purinergic nucleotide receptor signaling pathway (GO:0035590)2.65268266
94cornea development in camera-type eye (GO:0061303)2.64290433
95atrioventricular valve morphogenesis (GO:0003181)2.63103692
96response to phenylpropanoid (GO:0080184)2.61916892
97wound healing (GO:0042060)2.61321315
98positive regulation of action potential (GO:0045760)2.60523798
99histamine secretion (GO:0001821)2.57557815
100positive regulation of male gonad development (GO:2000020)2.56681344
101phosphatidylcholine acyl-chain remodeling (GO:0036151)2.56192911
102protein heterotetramerization (GO:0051290)2.55856581
103cell differentiation involved in kidney development (GO:0061005)2.54294483
104thyroid hormone generation (GO:0006590)2.53797222
105androgen biosynthetic process (GO:0006702)2.53627029
106regulation of epidermis development (GO:0045682)2.53295658
107negative regulation of homotypic cell-cell adhesion (GO:0034111)2.53053703
108antimicrobial humoral response (GO:0019730)2.52712369
109one-carbon compound transport (GO:0019755)2.52126231
110facial nerve structural organization (GO:0021612)2.52111859
111vitamin A metabolic process (GO:0006776)2.52064143
112cardiac muscle cell action potential involved in contraction (GO:0086002)2.51834169
113regulation of natural killer cell activation (GO:0032814)2.51491652
114cranial nerve morphogenesis (GO:0021602)2.50907899
115lipoxygenase pathway (GO:0019372)2.50688153
116superoxide metabolic process (GO:0006801)2.49802618
117DNA integration (GO:0015074)2.49778714
118positive regulation of uterine smooth muscle contraction (GO:0070474)2.49299284
119negative regulation of cell aging (GO:0090344)2.49064556
120positive regulation of interleukin-8 secretion (GO:2000484)2.48651131
121interferon-gamma production (GO:0032609)2.48632664
122regulation of neuron projection regeneration (GO:0070570)2.48494953
123regulation of axon regeneration (GO:0048679)2.48494953
124smooth muscle tissue development (GO:0048745)2.48382746
125cell proliferation in forebrain (GO:0021846)2.47173904
126cardiac muscle cell action potential (GO:0086001)2.47133224
127negative regulation of myoblast differentiation (GO:0045662)2.44961149
128cranial nerve structural organization (GO:0021604)2.44540325
129cochlea morphogenesis (GO:0090103)2.43628620
130regulation of protein polyubiquitination (GO:1902914)2.43349766
131inner ear receptor stereocilium organization (GO:0060122)2.41333967
132negative regulation of epidermis development (GO:0045683)2.41153934
133opioid receptor signaling pathway (GO:0038003)2.40960045
134histone H3-K4 trimethylation (GO:0080182)2.40775183
135negative regulation of DNA-dependent DNA replication (GO:2000104)2.39201344
136positive regulation of interleukin-1 beta secretion (GO:0050718)2.39161720
137inflammatory response to antigenic stimulus (GO:0002437)2.38204919
138regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.38201802
139detection of biotic stimulus (GO:0009595)2.38158066
140extracellular regulation of signal transduction (GO:1900115)2.37195037
141extracellular negative regulation of signal transduction (GO:1900116)2.37195037
142neutrophil activation (GO:0042119)2.36188811
143synapsis (GO:0007129)2.35771966
144non-canonical Wnt signaling pathway (GO:0035567)2.35539959
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.35493174
146positive regulation of monocyte chemotaxis (GO:0090026)2.35485946
147regulation of NIK/NF-kappaB signaling (GO:1901222)2.34117953
148epithelial cell-cell adhesion (GO:0090136)2.33879933
149positive regulation of T cell migration (GO:2000406)2.32957839
150regulation of keratinocyte proliferation (GO:0010837)2.32909881
151regulation of epidermal cell differentiation (GO:0045604)2.32306928
152positive regulation of protein homodimerization activity (GO:0090073)2.31526957
153phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.31522308
154developmental pigmentation (GO:0048066)2.30826818
155regulation of nuclear cell cycle DNA replication (GO:0033262)2.30541989
156positive regulation of toll-like receptor signaling pathway (GO:0034123)2.28282052
157startle response (GO:0001964)2.27603884
158purine ribonucleotide transport (GO:0015868)2.25678871
159negative regulation of stem cell proliferation (GO:2000647)2.25230092
160positive regulation of NIK/NF-kappaB signaling (GO:1901224)2.24978895
161regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.24908354
162generation of neurons (GO:0048699)2.23876007
163presynaptic membrane organization (GO:0097090)2.23817291
164amino sugar catabolic process (GO:0046348)2.23725323
165reflex (GO:0060004)2.23617998
166response to X-ray (GO:0010165)2.23348020
167tRNA methylation (GO:0030488)2.21337593
168poly(A)+ mRNA export from nucleus (GO:0016973)2.19696880
169pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.19455281
170positive regulation of lymphocyte migration (GO:2000403)2.19367830
171presynaptic membrane assembly (GO:0097105)2.19086656
172oligosaccharide catabolic process (GO:0009313)2.19023054
173cyclooxygenase pathway (GO:0019371)2.18434150
174positive regulation of interleukin-1 secretion (GO:0050716)2.17415633
175polyol transport (GO:0015791)2.16543336
176spinal cord association neuron differentiation (GO:0021527)2.15409290
177kinetochore assembly (GO:0051382)2.14269189
178response to folic acid (GO:0051593)2.14227386
179mesenchymal cell differentiation (GO:0048762)2.14081917
180ceramide catabolic process (GO:0046514)2.13976127
181histone H2B ubiquitination (GO:0033523)2.13915618
182mesonephros development (GO:0001823)2.13414776
183kidney morphogenesis (GO:0060993)2.12461836
184detection of external biotic stimulus (GO:0098581)2.12453146
185specification of organ identity (GO:0010092)2.12131861
186deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.11556692
187establishment of skin barrier (GO:0061436)15.3077141
188keratinocyte differentiation (GO:0030216)14.0874594
189peptide cross-linking (GO:0018149)13.6947227
190regulation of water loss via skin (GO:0033561)13.2156173
191epidermal cell differentiation (GO:0009913)11.1027059
192desmosome organization (GO:0002934)10.6323018

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.72188708
2SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.83181667
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.53564511
4P63_26484246_Chip-Seq_KERATINOCYTES_Human3.45868841
5GBX2_23144817_ChIP-Seq_PC3_Human3.18092331
6ESR1_21235772_ChIP-Seq_MCF-7_Human2.85119258
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.80457595
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.73149309
9FLI1_27457419_Chip-Seq_LIVER_Mouse2.64537574
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.62518111
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.55207754
12* SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.43032405
13* SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.43032405
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.42551459
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.42541378
16EZH2_22144423_ChIP-Seq_EOC_Human2.40665961
17NFE2_27457419_Chip-Seq_LIVER_Mouse2.37808478
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.37109011
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24298289
20ZNF217_24962896_ChIP-Seq_MCF-7_Human2.20677520
21STAT6_21828071_ChIP-Seq_BEAS2B_Human2.09692187
22CBX2_27304074_Chip-Seq_ESCs_Mouse2.09112180
23EZH2_27294783_Chip-Seq_NPCs_Mouse2.05700212
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02669808
25TP63_17297297_ChIP-ChIP_HaCaT_Human11.7557864
26TP63_19390658_ChIP-ChIP_HaCaT_Human1.99937061
27EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.99272121
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.99105250
29RNF2_27304074_Chip-Seq_NSC_Mouse1.98835664
30TP63_23658742_ChIP-Seq_EP156T_Human1.98175997
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.96709973
32SUZ12_18555785_Chip-Seq_ESCs_Mouse1.96139563
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.96061519
34TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.94850936
35E2F1_18555785_Chip-Seq_ESCs_Mouse1.93889494
36STAT3_18555785_Chip-Seq_ESCs_Mouse1.92298999
37P53_22387025_ChIP-Seq_ESCs_Mouse1.92242420
38NANOG_18555785_Chip-Seq_ESCs_Mouse1.91354402
39NMYC_18555785_Chip-Seq_ESCs_Mouse1.91163532
40IGF1R_20145208_ChIP-Seq_DFB_Human1.88906792
41GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.88543696
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.88387582
43* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.86914373
44EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.82073344
45P300_19829295_ChIP-Seq_ESCs_Human1.81482253
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.80196578
47FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.78222666
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77569606
49RUNX1_27457419_Chip-Seq_LIVER_Mouse1.74773820
50P300_18555785_Chip-Seq_ESCs_Mouse1.74534613
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.73521546
52EZH2_27304074_Chip-Seq_ESCs_Mouse1.71776844
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70193197
54OCT4_18555785_Chip-Seq_ESCs_Mouse1.69787203
55HIF1A_21447827_ChIP-Seq_MCF-7_Human1.68274832
56RXR_22108803_ChIP-Seq_LS180_Human1.68231961
57GATA6_21074721_ChIP-Seq_CACO-2_Human1.68031488
58TAF15_26573619_Chip-Seq_HEK293_Human1.68007740
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.67504439
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.66438616
61JARID2_20064375_ChIP-Seq_MESCs_Mouse1.66340051
62SOX2_20726797_ChIP-Seq_SW620_Human1.65288297
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.65260344
64SOX2_18555785_Chip-Seq_ESCs_Mouse1.65095381
65* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.64845575
66RARG_19884340_ChIP-ChIP_MEFs_Mouse1.64751498
67ESR1_20079471_ChIP-ChIP_T-47D_Human1.62374842
68KLF5_25053715_ChIP-Seq_YYC3_Human1.62264584
69ZFX_18555785_Chip-Seq_ESCs_Mouse1.62024821
70SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61224533
71ESRRB_18555785_Chip-Seq_ESCs_Mouse1.57891720
72TP63_22573176_ChIP-Seq_HFKS_Human1.56824179
73PU1_27457419_Chip-Seq_LIVER_Mouse1.56391046
74KLF4_18555785_Chip-Seq_ESCs_Mouse1.55707443
75CTCF_18555785_Chip-Seq_ESCs_Mouse1.53297575
76CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53025750
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.51399669
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.51355824
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51006495
80* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.49064460
81AHR_22903824_ChIP-Seq_MCF-7_Human1.49016487
82SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.48674070
83SMAD1_18555785_Chip-Seq_ESCs_Mouse1.45635141
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44710714
85CRX_20693478_ChIP-Seq_RETINA_Mouse1.44702285
86VDR_22108803_ChIP-Seq_LS180_Human1.44549155
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43591917
88HTT_18923047_ChIP-ChIP_STHdh_Human1.42798782
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42628054
90PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41412572
91ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.41096384
92* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40856694
93RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39853625
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.39632259
95* CJUN_26792858_Chip-Seq_BT549_Human1.38415364
96TAL1_26923725_Chip-Seq_HPCs_Mouse1.38249969
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37949311
98OCT4_21477851_ChIP-Seq_ESCs_Mouse1.37675727
99IRF1_19129219_ChIP-ChIP_H3396_Human1.35736328
100RNF2_27304074_Chip-Seq_ESCs_Mouse1.35405395
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.34327344
102FOXM1_26456572_ChIP-Seq_MCF-7_Human1.33577272
103SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.32879111
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.32571464
105SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.32484445
106TRIM28_21343339_ChIP-Seq_HEK293_Human1.30917658
107FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.29114156
108FUS_26573619_Chip-Seq_HEK293_Human1.28946625
109EWS_26573619_Chip-Seq_HEK293_Human1.28655537
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27778310
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.27139204
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.27139204
113AR_21572438_ChIP-Seq_LNCaP_Human1.26043099
114STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24553760
115ERG_20517297_ChIP-Seq_VCAP_Human1.23668810
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.23636384
117TP53_18474530_ChIP-ChIP_U2OS_Human1.23518693
118CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22365959
119SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.21609701
120SMAD4_21799915_ChIP-Seq_A2780_Human1.21582854
121TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21188103
122RBPJ_21746931_ChIP-Seq_IB4_Human1.19177428
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.19013932
124ER_23166858_ChIP-Seq_MCF-7_Human1.18701542
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.18508970
126CTCF_27219007_Chip-Seq_Bcells_Human1.17647408
127CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17061152
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.16043181
129GATA3_24758297_ChIP-Seq_MCF-7_Human1.15130719
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14476825
131IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12077099
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.11219935
133UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10832718
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.10419557
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06669755
136SMAD3_21741376_ChIP-Seq_HESCs_Human1.06045759
137CDX2_20551321_ChIP-Seq_CACO-2_Human1.05581670
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04975693
139SUZ12_27294783_Chip-Seq_ESCs_Mouse1.04856426
140CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03520774
141HNFA_21074721_ChIP-Seq_CACO-2_Human1.03340323
142ETV1_20927104_ChIP-Seq_GIST48_Human1.02364067
143SOX2_27498859_Chip-Seq_STOMACH_Mouse1.01984388
144EGR1_19032775_ChIP-ChIP_M12_Human1.01954308
145KDM2B_26808549_Chip-Seq_REH_Human1.01493694
146KAP1_22055183_ChIP-Seq_ESCs_Mouse1.01439157
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01413856
148POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01413856
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00746166
150RUNX2_22187159_ChIP-Seq_PCA_Human1.00609275
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.99392701
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.99392701
153PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.99350291
154ATF3_27146783_Chip-Seq_COLON_Human0.99156396
155PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98313301
156JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97457651
157CBX2_22325352_ChIP-Seq_293T-Rex_Human0.97266782
158BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95622962
159GATA4_25053715_ChIP-Seq_YYC3_Human0.92842719
160GATA6_25053715_ChIP-Seq_YYC3_Human0.91230398
161AR_25329375_ChIP-Seq_VCAP_Human0.89656346
162GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.88912451
163FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.88232040
164UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85319422
165AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82543589
166JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80071587
167RACK7_27058665_Chip-Seq_MCF-7_Human0.79475718
168GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79018752
169BCAT_22108803_ChIP-Seq_LS180_Human0.76420105
170CEBPB_22108803_ChIP-Seq_LS180_Human0.74722399
171PHF8_20622853_ChIP-Seq_HELA_Human0.74706758
172TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.73747538
173NFYB_21822215_ChIP-Seq_K562_Human0.73572194
174CTNNB1_20460455_ChIP-Seq_HCT116_Human0.73152093
175TP53_16413492_ChIP-PET_HCT116_Human0.73018867
176PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.72781797
177P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.71986829
178RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.70810405
179ERG_21242973_ChIP-ChIP_JURKAT_Human0.69875480
180ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.69844915
181MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.69465395
182TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.67001839
183* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.66442079
184TBL1_22424771_ChIP-Seq_293T_Human0.65403395
185UBF1/2_26484160_Chip-Seq_HMECs_Human0.64129618
186DNAJC2_21179169_ChIP-ChIP_NT2_Human0.63390551
187SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.62808016
188FOXA1_25552417_ChIP-Seq_VCAP_Human0.62660506

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier9.06771685
2MP0010234_abnormal_vibrissa_follicle7.29278307
3MP0005275_abnormal_skin_tensile5.23618259
4MP0005501_abnormal_skin_physiology5.15570961
5MP0003136_yellow_coat_color4.44335605
6MP0000566_synostosis4.39015967
7MP0006292_abnormal_olfactory_placode3.74075833
8MP0003453_abnormal_keratinocyte_physiol3.63463242
9MP0004381_abnormal_hair_follicle3.45587449
10MP0010678_abnormal_skin_adnexa3.44086542
11MP0001216_abnormal_epidermal_layer3.18589535
12MP0004885_abnormal_endolymph3.15268627
13MP0003787_abnormal_imprinting3.09439423
14MP0001188_hyperpigmentation3.07788206
15MP0000467_abnormal_esophagus_morphology2.93005644
16MP0004043_abnormal_pH_regulation2.90011354
17MP0010771_integument_phenotype2.75705783
18MP0002102_abnormal_ear_morphology2.68632846
19MP0005409_darkened_coat_color2.58383858
20MP0002277_abnormal_respiratory_mucosa2.57579930
21MP0002060_abnormal_skin_morphology2.38778157
22MP0010352_gastrointestinal_tract_polyps2.30149699
23MP0003941_abnormal_skin_development2.18719123
24MP0005171_absent_coat_pigmentation2.18367346
25MP0000377_abnormal_hair_follicle2.16217274
26MP0002132_abnormal_respiratory_system2.15233098
27MP0004264_abnormal_extraembryonic_tissu2.12895487
28MP0002148_abnormal_hypersensitivity_rea2.10333963
29MP0001986_abnormal_taste_sensitivity1.98902395
30MP0008058_abnormal_DNA_repair1.96881287
31MP0005646_abnormal_pituitary_gland1.90283199
32MP0009780_abnormal_chondrocyte_physiolo1.86823891
33MP0000465_gastrointestinal_hemorrhage1.84686384
34MP0000015_abnormal_ear_pigmentation1.80645737
35MP0008789_abnormal_olfactory_epithelium1.77395287
36MP0005451_abnormal_body_composition1.75609640
37MP0002009_preneoplasia1.74472934
38MP0005379_endocrine/exocrine_gland_phen1.73890413
39MP0005645_abnormal_hypothalamus_physiol1.69418399
40MP0002249_abnormal_larynx_morphology1.59499348
41MP0005174_abnormal_tail_pigmentation1.55531148
42MP0009053_abnormal_anal_canal1.52874042
43MP0001346_abnormal_lacrimal_gland1.51324313
44MP0004742_abnormal_vestibular_system1.51091543
45MP0000372_irregular_coat_pigmentation1.49786982
46MP0000026_abnormal_inner_ear1.49354644
47MP0004782_abnormal_surfactant_physiolog1.48968139
48MP0005075_abnormal_melanosome_morpholog1.48563031
49MP0003566_abnormal_cell_adhesion1.48194710
50MP0009931_abnormal_skin_appearance1.44645493
51MP0000049_abnormal_middle_ear1.44499143
52MP0005499_abnormal_olfactory_system1.42683638
53MP0005394_taste/olfaction_phenotype1.42683638
54MP0002163_abnormal_gland_morphology1.40925639
55MP0009697_abnormal_copulation1.40256283
56MP0001835_abnormal_antigen_presentation1.39483769
57MP0002095_abnormal_skin_pigmentation1.39070589
58MP0005671_abnormal_response_to1.36629346
59MP0003705_abnormal_hypodermis_morpholog1.36391134
60MP0001851_eye_inflammation1.36336906
61MP0003191_abnormal_cellular_cholesterol1.35611472
62MP0004947_skin_inflammation1.35488399
63MP0003724_increased_susceptibility_to1.35131242
64MP0009785_altered_susceptibility_to1.28393835
65MP0002638_abnormal_pupillary_reflex1.27737824
66MP0002876_abnormal_thyroid_physiology1.25939475
67MP0005503_abnormal_tendon_morphology1.25378391
68MP0000383_abnormal_hair_follicle1.24292121
69MP0001191_abnormal_skin_condition1.19499738
70MP0008995_early_reproductive_senescence1.16923049
71MP0009764_decreased_sensitivity_to1.15845306
72MP0005377_hearing/vestibular/ear_phenot1.15040459
73MP0003878_abnormal_ear_physiology1.15040459
74MP0000762_abnormal_tongue_morphology1.13346003
75MP0001963_abnormal_hearing_physiology1.11060156
76MP0010386_abnormal_urinary_bladder1.09712614
77MP0000367_abnormal_coat/_hair1.07818605
78MP0001790_abnormal_immune_system1.05220520
79MP0005387_immune_system_phenotype1.05220520
80MP0002098_abnormal_vibrissa_morphology1.04838629
81MP0000678_abnormal_parathyroid_gland1.03166643
82MP0000613_abnormal_salivary_gland1.01748086
83MP0002751_abnormal_autonomic_nervous1.01574196
84MP0005000_abnormal_immune_tolerance1.01155654
85MP0001486_abnormal_startle_reflex1.00449441
86MP0002234_abnormal_pharynx_morphology0.99867509
87MP0003938_abnormal_ear_development0.99614563
88MP0008877_abnormal_DNA_methylation0.98633789
89MP0002938_white_spotting0.97436201
90MP0001186_pigmentation_phenotype0.97120900
91MP0003828_pulmonary_edema0.96223091
92MP0002419_abnormal_innate_immunity0.91775176
93MP0004185_abnormal_adipocyte_glucose0.91416749
94MP0008057_abnormal_DNA_replication0.90595911
95MP0000631_abnormal_neuroendocrine_gland0.90293602
96MP0001784_abnormal_fluid_regulation0.89773552
97MP0002177_abnormal_outer_ear0.89516117
98MP0003763_abnormal_thymus_physiology0.89068088
99MP0005253_abnormal_eye_physiology0.89030452
100MP0005423_abnormal_somatic_nervous0.88606194
101MP0005551_abnormal_eye_electrophysiolog0.88194215
102MP0001243_abnormal_dermal_layer0.87415333
103MP0005025_abnormal_response_to0.86579269
104MP0005023_abnormal_wound_healing0.85344399
105MP0008260_abnormal_autophagy0.85264348
106MP0001984_abnormal_olfaction0.84450331
107MP0003786_premature_aging0.83096845
108MP0003315_abnormal_perineum_morphology0.81708550
109MP0003718_maternal_effect0.81164976
110MP0000681_abnormal_thyroid_gland0.80829500
111MP0001919_abnormal_reproductive_system0.80388314
112MP0001800_abnormal_humoral_immune0.80091632
113MP0000579_abnormal_nail_morphology0.79221867
114MP0003755_abnormal_palate_morphology0.78791171
115MP0003011_delayed_dark_adaptation0.77883379
116MP0000470_abnormal_stomach_morphology0.77404988
117MP0000569_abnormal_digit_pigmentation0.77217899
118MP0002723_abnormal_immune_serum0.76996842
119MP0002075_abnormal_coat/hair_pigmentati0.76914198
120MP0001119_abnormal_female_reproductive0.76881993
121MP0000778_abnormal_nervous_system0.76789133
122MP0000647_abnormal_sebaceous_gland0.75093638
123MP0001485_abnormal_pinna_reflex0.74661652
124MP0002452_abnormal_antigen_presenting0.74166520
125MP0001502_abnormal_circadian_rhythm0.72947222
126MP0002233_abnormal_nose_morphology0.72870639
127MP0000427_abnormal_hair_cycle0.71788938
128MP0001819_abnormal_immune_cell0.71737635
129MP0002420_abnormal_adaptive_immunity0.71483558
130MP0010030_abnormal_orbit_morphology0.70807515
131MP0009250_abnormal_appendicular_skeleto0.70488098
132MP0002405_respiratory_system_inflammati0.70447584
133MP0003121_genomic_imprinting0.70340699
134MP0004142_abnormal_muscle_tone0.69896863
135MP0002735_abnormal_chemical_nociception0.69437600
136MP0002111_abnormal_tail_morphology0.65146352
137MP0001340_abnormal_eyelid_morphology0.53726657
138MP0005666_abnormal_adipose_tissue0.44984407
139MP0003950_abnormal_plasma_membrane0.44955710
140MP0004197_abnormal_fetal_growth/weight/0.42444607
141MP0005193_abnormal_anterior_eye0.38528718
142MP0001765_abnormal_ion_homeostasis0.37323168
143MP0002282_abnormal_trachea_morphology0.36358757
144MP0002877_abnormal_melanocyte_morpholog0.31739601
145MP0003638_abnormal_response/metabolism_0.30361587
146MP0005375_adipose_tissue_phenotype0.29994655
147MP0002133_abnormal_respiratory_system0.27266999
148MP0005388_respiratory_system_phenotype0.27266999
149MP0001299_abnormal_eye_distance/0.26256385
150MP0003937_abnormal_limbs/digits/tail_de0.25554297
151MP0000371_diluted_coat_color0.25484811
152MP0001879_abnormal_lymphatic_vessel0.23538954
153MP0001270_distended_abdomen0.23009378
154MP0004270_analgesia0.21378735
155MP0008569_lethality_at_weaning0.21339001
156MP0000858_altered_metastatic_potential0.20412469
157MP0008004_abnormal_stomach_pH0.20321786
158MP0004019_abnormal_vitamin_homeostasis0.19817891
159MP0001958_emphysema0.19134886
160MP0002081_perinatal_lethality0.18912192
161MP0001756_abnormal_urination0.18548281
162MP0001177_atelectasis0.18113293
163MP0005248_abnormal_Harderian_gland0.16852999
164MP0000627_abnormal_mammary_gland0.16706771
165MP0002108_abnormal_muscle_morphology0.16036128
166MP0000432_abnormal_head_morphology0.15936019
167MP0003045_fibrosis0.15808919
168MP0002138_abnormal_hepatobiliary_system0.15011656

Predicted human phenotypes

RankGene SetZ-score
1Oral leukoplakia (HP:0002745)7.86581263
2Alopecia of scalp (HP:0002293)7.25171685
3Congenital ichthyosiform erythroderma (HP:0007431)7.10147079
4Palmoplantar hyperkeratosis (HP:0000972)6.85589516
5Increased IgE level (HP:0003212)6.84415868
6Erythroderma (HP:0001019)6.77149248
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)6.57374318
8Palmar hyperkeratosis (HP:0010765)6.52869782
9Corneal erosion (HP:0200020)6.01177426
10Onycholysis (HP:0001806)5.88261942
11Thick nail (HP:0001805)5.80614750
12Plantar hyperkeratosis (HP:0007556)5.66073563
13Chromosomal breakage induced by crosslinking agents (HP:0003221)5.65999177
14Hypotrichosis (HP:0001006)5.46221489
15Right ventricular cardiomyopathy (HP:0011663)5.00669329
16Chromsome breakage (HP:0040012)5.00448193
17Abnormality of the salivary glands (HP:0010286)4.57053846
18Absent eyelashes (HP:0000561)4.42840051
19Ectropion (HP:0000656)4.39587688
20Nail dystrophy (HP:0008404)4.32573216
21Hypohidrosis (HP:0000966)4.29049715
22Erythema (HP:0010783)4.07601158
23Absent hair (HP:0002298)3.91615998
24Pustule (HP:0200039)3.86779428
25Sparse eyelashes (HP:0000653)3.81255789
26Sparse scalp hair (HP:0002209)3.79670774
27Duplicated collecting system (HP:0000081)3.73658567
28Woolly hair (HP:0002224)3.60943200
29Palmoplantar keratoderma (HP:0000982)3.55148417
30Hypoplastic labia majora (HP:0000059)3.51317896
31Abnormality of the renal collecting system (HP:0004742)3.41225257
32Prostate neoplasm (HP:0100787)3.37186698
33Oligodontia (HP:0000677)3.27935440
34Gangrene (HP:0100758)3.21086365
35Abnormality of the labia majora (HP:0012881)3.19187229
36Furrowed tongue (HP:0000221)3.09522432
37Blepharitis (HP:0000498)3.07008003
38Amniotic constriction ring (HP:0009775)3.01433794
39Abnormality of placental membranes (HP:0011409)3.01433794
40Renal cortical cysts (HP:0000803)2.95170515
41Milia (HP:0001056)2.89824927
42Osteomalacia (HP:0002749)2.88602466
43Fragile nails (HP:0001808)2.84554334
44Abnormality of incisor morphology (HP:0011063)2.79102337
45Absent/shortened dynein arms (HP:0200106)2.78498089
46Dynein arm defect of respiratory motile cilia (HP:0012255)2.78498089
47Aplasia cutis congenita (HP:0001057)2.77791210
48Abnormality of DNA repair (HP:0003254)2.77172885
49Abnormal hair laboratory examination (HP:0003328)2.75968545
50Ectopic kidney (HP:0000086)2.75032981
51Upper limb muscle weakness (HP:0003484)2.74781910
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.72307863
53Aplasia/Hypoplasia of the fovea (HP:0008060)2.70973011
54Hypoplasia of the fovea (HP:0007750)2.70973011
55Conical tooth (HP:0000698)2.68126108
56Autoamputation (HP:0001218)2.67272870
57White forelock (HP:0002211)2.64943734
58Stomach cancer (HP:0012126)2.63452815
59Abnormality of the preputium (HP:0100587)2.61565859
60Septo-optic dysplasia (HP:0100842)2.57720095
61Dehydration (HP:0001944)2.54834215
62Lip pit (HP:0100267)2.53600539
63Pruritus (HP:0000989)2.51986787
64Brittle hair (HP:0002299)2.51904742
65Febrile seizures (HP:0002373)2.51689466
66Clubbing of toes (HP:0100760)2.51233616
67Optic neuritis (HP:0100653)2.48681110
68Retrobulbar optic neuritis (HP:0100654)2.48681110
69Labial hypoplasia (HP:0000066)2.47857286
70Abnormal blistering of the skin (HP:0008066)2.46659539
71Patchy hypopigmentation of hair (HP:0011365)2.43119238
72Pili torti (HP:0003777)2.42400175
73Aplasia/Hypoplasia of the uvula (HP:0010293)2.40863873
74Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.39541184
75Popliteal pterygium (HP:0009756)2.37314666
76Widely patent fontanelles and sutures (HP:0004492)2.34622866
77Recurrent corneal erosions (HP:0000495)2.32438813
78Multifactorial inheritance (HP:0001426)2.32246729
79Abnormality of the prostate (HP:0008775)2.29223007
80Optic nerve hypoplasia (HP:0000609)2.27512226
81Hypoplastic female external genitalia (HP:0012815)2.27120707
82True hermaphroditism (HP:0010459)2.25580997
83Congenital sensorineural hearing impairment (HP:0008527)2.24698415
84Split foot (HP:0001839)2.23687270
85Increased IgM level (HP:0003496)2.22964436
86Abnormality of the nasal septum (HP:0000419)2.22783397
87Meckel diverticulum (HP:0002245)2.22455581
88Chronic hepatic failure (HP:0100626)2.20952988
89Abnormality of secondary sexual hair (HP:0009888)2.19525177
90Abnormality of the axillary hair (HP:0100134)2.19525177
91Acanthosis nigricans (HP:0000956)2.17875891
92Selective tooth agenesis (HP:0001592)2.17241767
93Hyperactive renin-angiotensin system (HP:0000841)2.16574336
94Urticaria (HP:0001025)2.16377147
95Xerostomia (HP:0000217)2.14930222
96Ridged nail (HP:0001807)2.13252722
97Lack of skin elasticity (HP:0100679)2.12751363
98Abnormality of the ileum (HP:0001549)2.12443169
99Tubulointerstitial nephritis (HP:0001970)2.12072125
100Thyroid-stimulating hormone excess (HP:0002925)2.10600051
101Abnormal ciliary motility (HP:0012262)2.09113272
102Slow-growing hair (HP:0002217)2.07301341
103Abnormality of hair growth rate (HP:0011363)2.07301341
104Duplication of thumb phalanx (HP:0009942)2.05873624
105Parakeratosis (HP:0001036)2.02218533
106Nephroblastoma (Wilms tumor) (HP:0002667)2.01321593
107Abnormality of nail color (HP:0100643)10.9795633
108Atelectasis (HP:0100750)1.99407549
109Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98563326
110Abnormality of the fovea (HP:0000493)1.98043652
111Submucous cleft hard palate (HP:0000176)1.97900377
112Chronic obstructive pulmonary disease (HP:0006510)1.96354014
113Obstructive lung disease (HP:0006536)1.96354014
114Embryonal renal neoplasm (HP:0011794)1.95823355
115Abnormality of the renal cortex (HP:0011035)1.95751869
116Sex reversal (HP:0012245)1.95316480
117Abnormal sex determination (HP:0012244)1.95316480
118Abnormality of the incisor (HP:0000676)1.94715601
119Curly hair (HP:0002212)1.93723221
120Preaxial hand polydactyly (HP:0001177)1.92777130
121Congenital stationary night blindness (HP:0007642)1.92423535
122Hypothermia (HP:0002045)1.92283763
123Abnormality of chromosome stability (HP:0003220)1.91993009
124Abnormality of male internal genitalia (HP:0000022)1.90329962
125Recurrent abscess formation (HP:0002722)1.89908396
126Follicular hyperkeratosis (HP:0007502)1.89862821
127Type I transferrin isoform profile (HP:0003642)1.89757062
128Skin pits (HP:0100276)1.89695233
129Abnormal respiratory epithelium morphology (HP:0012253)1.89414985
130Abnormal respiratory motile cilium morphology (HP:0005938)1.89414985
131Abnormality of small intestinal villus morphology (HP:0011472)1.89278006
132Villous atrophy (HP:0011473)1.89278006
133Alveolar cell carcinoma (HP:0006519)1.88103004
134Decreased central vision (HP:0007663)1.87579639
135Fine hair (HP:0002213)1.87527283
136Abnormal hair whorl (HP:0010721)1.87238890
137Abnormality of molar morphology (HP:0011070)1.87204320
138Abnormality of molar (HP:0011077)1.87204320
139Asplenia (HP:0001746)1.85829881
140Hyperkalemia (HP:0002153)1.84873258
141Anomalous pulmonary venous return (HP:0010772)1.84308147
142Median cleft lip (HP:0000161)1.83648438
143Depressed nasal tip (HP:0000437)1.83418065
144Syncope (HP:0001279)1.82065769
145Male pseudohermaphroditism (HP:0000037)1.81270610
146Hypergammaglobulinemia (HP:0010702)1.80460303
147Increased number of teeth (HP:0011069)1.80174535
148Nasolacrimal duct obstruction (HP:0000579)1.79709054
149Nephronophthisis (HP:0000090)1.79347968
150Anonychia (HP:0001798)1.78585797
151Paralysis (HP:0003470)1.77623853
152Abnormality of the renal medulla (HP:0100957)1.76041719
153Dry skin (HP:0000958)1.75965707
154Adrenal hypoplasia (HP:0000835)1.75675264
155Recurrent pneumonia (HP:0006532)1.74125544
156Encephalitis (HP:0002383)1.73988828
157Melanocytic nevus (HP:0000995)1.72547722
158Orchitis (HP:0100796)1.71138770
159Oligohydramnios (HP:0001562)1.70860651
160Septate vagina (HP:0001153)1.70274167
161Pulmonary artery stenosis (HP:0004415)1.70191265
162Abnormal respiratory motile cilium physiology (HP:0012261)1.69596279
163Renal agenesis (HP:0000104)1.68467204
164Corneal dystrophy (HP:0001131)1.68415633
165Abnormality of the lacrimal duct (HP:0011481)1.67296776
166Malnutrition (HP:0004395)1.65654456
167Laryngomalacia (HP:0001601)1.64873663
168Abnormality of the labia (HP:0000058)1.64812214
169Abnormality of the columella (HP:0009929)1.64129527
170Abnormality of the dental root (HP:0006486)1.63909957
171Taurodontia (HP:0000679)1.63909957
172Abnormality of permanent molar morphology (HP:0011071)1.63909957
173Triphalangeal thumb (HP:0001199)1.63576729
174Distal lower limb muscle weakness (HP:0009053)1.62933585
175Dry hair (HP:0011359)1.62823674
176Protruding tongue (HP:0010808)1.62271093
177Absent septum pellucidum (HP:0001331)1.61556197
178Reticulocytopenia (HP:0001896)1.61477020
179Overfolded helix (HP:0000396)1.61102340
180Squamous cell carcinoma (HP:0002860)1.60048018
181Anhidrosis (HP:0000970)1.58938457
182Breast hypoplasia (HP:0003187)1.58743040
183Abnormality of the dental pulp (HP:0006479)1.56428827
184Hypoplastic toenails (HP:0001800)1.56229516
185Chronic bronchitis (HP:0004469)1.54317920
186Fair hair (HP:0002286)1.53813807
187Carious teeth (HP:0000670)1.52997193

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K95.20557056
2TGFBR14.49321802
3CASK4.20811199
4MAPKAPK33.92755172
5MAP3K63.86164222
6MAP3K23.44124162
7IRAK43.16205370
8STK163.08541625
9MAP3K143.05553283
10ZAK2.73360337
11RIPK12.71612152
12IRAK32.59407249
13FER2.52081859
14MST1R2.51177213
15TNIK2.42937687
16TXK2.41379745
17MAP3K32.41208599
18NME12.32974050
19EIF2AK22.19545020
20SIK32.18612609
21BMPR22.16304591
22BLK2.08577591
23STK242.03034007
24GRK11.93092652
25STK391.87848552
26YES11.87415269
27NEK61.86457966
28FGFR31.85098375
29ERBB31.83492003
30BMPR1B1.76487485
31MAP2K71.65989036
32WNK41.65692078
33ADRBK21.58106596
34MET1.56978430
35FGFR11.47795992
36WNK11.47605748
37CDK31.44908252
38INSRR1.44753906
39MKNK21.44527662
40STK38L1.42226630
41MAP3K41.42034268
42GRK61.40675384
43MAPK131.40242325
44AKT31.38312216
45SRPK11.31812475
46SGK21.31031438
47DMPK1.30673135
48TYRO31.29026730
49TEC1.26854706
50MAP3K71.26572834
51IRAK21.25618606
52IKBKB1.25316465
53MKNK11.23259767
54PRPF4B1.21664650
55NUAK11.18728655
56RPS6KB21.17088201
57IKBKE1.12977364
58MUSK1.11513664
59PIK3CG1.07838944
60ACVR1B1.04302262
61CLK11.01353636
62IRAK11.01013114
63NLK0.99139058
64PKN10.97029880
65CHUK0.94563397
66GRK70.91451665
67EPHA30.90994612
68TAOK10.90143517
69BCR0.88866957
70PLK40.88102185
71PBK0.85268206
72TRPM70.84636302
73PDK20.84172421
74PINK10.80864159
75PIK3CA0.80650610
76SGK4940.79844778
77SGK2230.79844778
78PTK20.76365459
79MAPK70.75788320
80CCNB10.73407554
81CAMK1D0.72163964
82TNK20.72098180
83MAP3K130.68675340
84RIPK40.68528481
85PRKCE0.67091029
86VRK10.66785828
87EPHB10.66652054
88JAK30.64993560
89DYRK20.64204333
90BTK0.59749739
91PRKD20.55494367
92EPHA20.55365557
93SGK30.52272138
94MAPK150.52077406
95OBSCN0.51570920
96MARK20.51329625
97LYN0.51008317
98BRD40.48983647
99MAP3K10.48947400
100ATR0.45926341
101CAMK1G0.45781368
102EPHA40.45286189
103DDR20.44846039
104TLK10.44280687
105KIT0.44003632
106NTRK20.43086124
107FRK0.42355851
108CSNK1A1L0.42213931
109CDK80.41050691
110HIPK20.40743643
111MAPKAPK20.40126295
112CHEK20.39373533
113FGFR20.38650390
114MST40.36769452
115CSK0.36618874
116PLK20.35493714
117DYRK1A0.35288059
118TAOK30.35226189
119PIM10.35172129
120RPS6KB10.34561206
121SYK0.34480782
122PDGFRB0.34248293
123EPHB20.33688242
124MAP2K40.33634090
125PRKAA20.33456180
126LRRK20.31928784
127SGK10.31688349
128AKT10.30980254
129STK30.30684742
130LCK0.30322179
131SIK20.30249079
132MARK30.30205078
133MARK10.30120914
134PRKCQ0.29911593
135LATS10.29822744
136ERN10.28235715
137MAP2K60.27927689
138BCKDK0.27765979
139TBK10.27680579
140PRKACA0.27457637
141CSNK1A10.27087715
142RET0.26648033
143RPS6KC10.26629932
144RPS6KL10.26629932
145CDC42BPA0.26467861
146MATK0.26359812
147PLK30.26245917
148FGFR40.24767698
149FGR0.22323410
150PKN20.21583951
151ABL10.21244202
152SIK10.21018755
153MELK0.19852750
154FLT30.19591265
155RPS6KA20.18534354
156AKT20.15416857
157ERBB20.15307792
158CDK120.14627596
159FYN0.13432867
160MTOR0.13078770

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.92680095
2Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.49902805
3Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.37509028
4Allograft rejection_Homo sapiens_hsa053302.36325375
5Graft-versus-host disease_Homo sapiens_hsa053322.32088744
6GnRH signaling pathway_Homo sapiens_hsa049122.29705399
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23663068
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.13073686
9Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047502.11406655
10Autoimmune thyroid disease_Homo sapiens_hsa053202.08287339
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.05672665
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.99819864
13Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.88429167
14Non-homologous end-joining_Homo sapiens_hsa034501.87969354
15Phototransduction_Homo sapiens_hsa047441.87455835
16Arachidonic acid metabolism_Homo sapiens_hsa005901.87446244
17Intestinal immune network for IgA production_Homo sapiens_hsa046721.82061147
18VEGF signaling pathway_Homo sapiens_hsa043701.79878293
19Circadian rhythm_Homo sapiens_hsa047101.79607321
20Amoebiasis_Homo sapiens_hsa051461.76493432
21Renin secretion_Homo sapiens_hsa049241.74160465
22Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73949817
23Homologous recombination_Homo sapiens_hsa034401.72463101
24Histidine metabolism_Homo sapiens_hsa003401.67315762
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.66640857
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.63219041
27Primary immunodeficiency_Homo sapiens_hsa053401.53067540
28Sphingolipid metabolism_Homo sapiens_hsa006001.49232339
29Salivary secretion_Homo sapiens_hsa049701.48932654
30Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40548455
31Asthma_Homo sapiens_hsa053101.40113801
32Hematopoietic cell lineage_Homo sapiens_hsa046401.37352027
33Nicotine addiction_Homo sapiens_hsa050331.37313263
34Measles_Homo sapiens_hsa051621.35680411
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35368895
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.33795486
37Basal transcription factors_Homo sapiens_hsa030221.30886506
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.30688011
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30084696
40Rheumatoid arthritis_Homo sapiens_hsa053231.27825969
41Adherens junction_Homo sapiens_hsa045201.24423562
42Taste transduction_Homo sapiens_hsa047421.22862807
43Bladder cancer_Homo sapiens_hsa052191.21765624
44Steroid biosynthesis_Homo sapiens_hsa001001.19646491
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.19271099
46Choline metabolism in cancer_Homo sapiens_hsa052311.18759519
47Ras signaling pathway_Homo sapiens_hsa040141.18090648
48Type I diabetes mellitus_Homo sapiens_hsa049401.17129376
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16697904
50Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16085368
51Dorso-ventral axis formation_Homo sapiens_hsa043201.15742397
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.12997580
53Long-term depression_Homo sapiens_hsa047301.12710849
54Herpes simplex infection_Homo sapiens_hsa051681.11782697
55RNA polymerase_Homo sapiens_hsa030201.11130169
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07700168
57Ether lipid metabolism_Homo sapiens_hsa005651.07444342
58Steroid hormone biosynthesis_Homo sapiens_hsa001401.05633666
59Gastric acid secretion_Homo sapiens_hsa049711.05560824
60Tight junction_Homo sapiens_hsa045301.03545715
61Glioma_Homo sapiens_hsa052140.99222055
62Leishmaniasis_Homo sapiens_hsa051400.98783030
63Linoleic acid metabolism_Homo sapiens_hsa005910.91826151
64Malaria_Homo sapiens_hsa051440.91693170
65Jak-STAT signaling pathway_Homo sapiens_hsa046300.91401253
66Inositol phosphate metabolism_Homo sapiens_hsa005620.90674995
67Oxytocin signaling pathway_Homo sapiens_hsa049210.90618316
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88581685
69Acute myeloid leukemia_Homo sapiens_hsa052210.88009198
70Other glycan degradation_Homo sapiens_hsa005110.86712581
71alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85071745
72One carbon pool by folate_Homo sapiens_hsa006700.84094209
73Serotonergic synapse_Homo sapiens_hsa047260.83745716
74MicroRNAs in cancer_Homo sapiens_hsa052060.83715777
75Retinol metabolism_Homo sapiens_hsa008300.83298796
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.83118118
77Base excision repair_Homo sapiens_hsa034100.82116329
78Pyrimidine metabolism_Homo sapiens_hsa002400.81869892
79TNF signaling pathway_Homo sapiens_hsa046680.79158209
80Glutamatergic synapse_Homo sapiens_hsa047240.78610509
81Basal cell carcinoma_Homo sapiens_hsa052170.78112725
82Influenza A_Homo sapiens_hsa051640.77979877
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.77777096
84Melanogenesis_Homo sapiens_hsa049160.77483413
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77389603
86Purine metabolism_Homo sapiens_hsa002300.76977130
87Long-term potentiation_Homo sapiens_hsa047200.76444614
88DNA replication_Homo sapiens_hsa030300.75872256
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.75860426
90Mismatch repair_Homo sapiens_hsa034300.73608977
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73001582
92Pancreatic cancer_Homo sapiens_hsa052120.72843398
93Pancreatic secretion_Homo sapiens_hsa049720.71847486
94Axon guidance_Homo sapiens_hsa043600.71829598
95Pertussis_Homo sapiens_hsa051330.70879567
96MAPK signaling pathway_Homo sapiens_hsa040100.70779478
97African trypanosomiasis_Homo sapiens_hsa051430.70573292
98ABC transporters_Homo sapiens_hsa020100.69358155
99RNA degradation_Homo sapiens_hsa030180.66002750
100Glycosaminoglycan degradation_Homo sapiens_hsa005310.65252016
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.63657303
102Rap1 signaling pathway_Homo sapiens_hsa040150.63517350
103Morphine addiction_Homo sapiens_hsa050320.62971562
104Nucleotide excision repair_Homo sapiens_hsa034200.62764091
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62689398
106Hedgehog signaling pathway_Homo sapiens_hsa043400.62314606
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.62272327
108Hippo signaling pathway_Homo sapiens_hsa043900.62133091
109Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62014466
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61585871
111Estrogen signaling pathway_Homo sapiens_hsa049150.61275957
112Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60969097
113Tyrosine metabolism_Homo sapiens_hsa003500.59649698
114Endocytosis_Homo sapiens_hsa041440.58384053
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.58232151
116Chemokine signaling pathway_Homo sapiens_hsa040620.57671615
117p53 signaling pathway_Homo sapiens_hsa041150.56331344
118Ovarian steroidogenesis_Homo sapiens_hsa049130.56315479
119Wnt signaling pathway_Homo sapiens_hsa043100.56130979
120Regulation of autophagy_Homo sapiens_hsa041400.55691143
121ErbB signaling pathway_Homo sapiens_hsa040120.55003739
122Platelet activation_Homo sapiens_hsa046110.54070717
123Renal cell carcinoma_Homo sapiens_hsa052110.54058223
124Phagosome_Homo sapiens_hsa041450.53886059
125Notch signaling pathway_Homo sapiens_hsa043300.53850812
126Insulin signaling pathway_Homo sapiens_hsa049100.52587788
127Osteoclast differentiation_Homo sapiens_hsa043800.51918667
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51812497
129Protein export_Homo sapiens_hsa030600.51178197
130Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51133754
131Circadian entrainment_Homo sapiens_hsa047130.49062566
132Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.48071712
133T cell receptor signaling pathway_Homo sapiens_hsa046600.48062822
134beta-Alanine metabolism_Homo sapiens_hsa004100.47699582
135Tuberculosis_Homo sapiens_hsa051520.46758537
136Hepatitis C_Homo sapiens_hsa051600.46309798
137Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44965616
138Cell cycle_Homo sapiens_hsa041100.44229820
139Vitamin digestion and absorption_Homo sapiens_hsa049770.42899535
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42556371
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.42292555
142Chemical carcinogenesis_Homo sapiens_hsa052040.41552348
143cAMP signaling pathway_Homo sapiens_hsa040240.41548251
144Apoptosis_Homo sapiens_hsa042100.40881916
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39682119
146Pathways in cancer_Homo sapiens_hsa052000.38847228
147Melanoma_Homo sapiens_hsa052180.38138483
148Amphetamine addiction_Homo sapiens_hsa050310.38117945
149ECM-receptor interaction_Homo sapiens_hsa045120.37753072
150Salmonella infection_Homo sapiens_hsa051320.37621376
151Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37596369
152Calcium signaling pathway_Homo sapiens_hsa040200.37389169
153Prostate cancer_Homo sapiens_hsa052150.36402762
154Staphylococcus aureus infection_Homo sapiens_hsa051500.36067709
155Legionellosis_Homo sapiens_hsa051340.36066006
156Mineral absorption_Homo sapiens_hsa049780.35466355
157Arginine biosynthesis_Homo sapiens_hsa002200.35423713
158Hepatitis B_Homo sapiens_hsa051610.35066689
159AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.34563642
160Proteoglycans in cancer_Homo sapiens_hsa052050.34229789
161Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.33228096
162Phenylalanine metabolism_Homo sapiens_hsa003600.33193393
163Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33097202
164TGF-beta signaling pathway_Homo sapiens_hsa043500.33097151
165PPAR signaling pathway_Homo sapiens_hsa033200.33067774
166Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33051168
167Dilated cardiomyopathy_Homo sapiens_hsa054140.32577039
168Thyroid cancer_Homo sapiens_hsa052160.32093595

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