TMPPE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.26086728
2proteasome assembly (GO:0043248)5.22294941
3positive regulation of gamma-delta T cell activation (GO:0046645)4.84259990
4response to peptidoglycan (GO:0032494)4.60594729
5cellular extravasation (GO:0045123)4.53681563
6neutrophil activation involved in immune response (GO:0002283)4.52255237
7detection of molecule of bacterial origin (GO:0032490)4.37910350
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.31314574
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.27719227
10positive regulation by organism of defense response of other organism involved in symbiotic interact4.27719227
11modulation by symbiont of host immune response (GO:0052553)4.27719227
12positive regulation by symbiont of host defense response (GO:0052509)4.27719227
13modulation by symbiont of host defense response (GO:0052031)4.27719227
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.27719227
15ribosome assembly (GO:0042255)4.26200635
16ribosomal small subunit biogenesis (GO:0042274)4.22988622
17amino sugar catabolic process (GO:0046348)4.21311608
18positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.12293805
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.08992065
20termination of RNA polymerase III transcription (GO:0006386)4.08992065
21GMP metabolic process (GO:0046037)4.02422308
22maturation of SSU-rRNA (GO:0030490)4.00905821
23negative regulation of erythrocyte differentiation (GO:0045647)3.80669945
24macrophage activation involved in immune response (GO:0002281)3.77062737
25regulation of B cell receptor signaling pathway (GO:0050855)3.75189075
26ribosomal large subunit biogenesis (GO:0042273)3.71692716
27telomere maintenance via semi-conservative replication (GO:0032201)3.70988663
28negative regulation of interleukin-12 production (GO:0032695)3.69239740
29hepatocyte apoptotic process (GO:0097284)3.59496755
30response to muramyl dipeptide (GO:0032495)3.58024726
31DNA replication initiation (GO:0006270)3.51092131
32regulation of gamma-delta T cell activation (GO:0046643)3.51064813
33detection of other organism (GO:0098543)3.50896797
34positive regulation of mast cell activation (GO:0033005)3.50588811
35hypotonic response (GO:0006971)3.49156277
36DNA replication checkpoint (GO:0000076)3.44424982
37negative regulation of transcription by competitive promoter binding (GO:0010944)3.43962273
38detection of external biotic stimulus (GO:0098581)3.43893314
39regulation of mast cell degranulation (GO:0043304)3.41928273
40ribonucleoprotein complex biogenesis (GO:0022613)3.40880116
41macrophage activation (GO:0042116)3.40731792
42embryonic process involved in female pregnancy (GO:0060136)3.38809579
43telomere maintenance via recombination (GO:0000722)3.36444643
44regulation of interferon-beta biosynthetic process (GO:0045357)3.36008213
45viral transcription (GO:0019083)3.34765275
46pseudouridine synthesis (GO:0001522)3.34131983
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.33745677
48histone H3-K36 demethylation (GO:0070544)3.29828773
49regulation of gamma-delta T cell differentiation (GO:0045586)3.27784941
50negative regulation of cell killing (GO:0031342)3.26788488
51negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.26788488
52N-acetylneuraminate metabolic process (GO:0006054)3.25629994
53regulation of leukocyte degranulation (GO:0043300)3.25435948
54ribosomal small subunit assembly (GO:0000028)3.24213801
55neutrophil activation (GO:0042119)3.24164642
56regulation of mast cell activation involved in immune response (GO:0033006)3.22765752
57rRNA processing (GO:0006364)3.22716434
58translational termination (GO:0006415)3.21280444
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.19831583
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.17828026
61response to host immune response (GO:0052572)3.17828026
62B cell receptor signaling pathway (GO:0050853)3.14207023
63transcription elongation from RNA polymerase I promoter (GO:0006362)3.14176675
64microglial cell activation (GO:0001774)3.11612378
65megakaryocyte development (GO:0035855)3.11039762
66granulocyte activation (GO:0036230)3.11029801
67neutrophil mediated immunity (GO:0002446)3.11004519
68rRNA metabolic process (GO:0016072)3.10944229
69termination of RNA polymerase I transcription (GO:0006363)3.10766141
70regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033393.09453289
71peptidyl-threonine dephosphorylation (GO:0035970)3.09349916
72regulation of mast cell activation (GO:0033003)3.09086906
73regulation of double-strand break repair via homologous recombination (GO:0010569)3.08993269
74regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.08368852
75positive regulation of cellular amide metabolic process (GO:0034250)3.08105042
76response to folic acid (GO:0051593)3.07349008
77detection of biotic stimulus (GO:0009595)3.07311525
78rRNA modification (GO:0000154)3.07245221
79regulation of histone H3-K27 methylation (GO:0061085)3.06958734
80myeloid cell activation involved in immune response (GO:0002275)3.06648686
81regulation of myeloid leukocyte mediated immunity (GO:0002886)3.05957737
82response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.05844456
83response to host (GO:0075136)3.05844456
84response to host defenses (GO:0052200)3.05844456
85ribosome biogenesis (GO:0042254)3.00837711
86purine nucleobase biosynthetic process (GO:0009113)3.00436484
87respiratory chain complex IV assembly (GO:0008535)3.00073331
88positive regulation of leukocyte degranulation (GO:0043302)2.99487840
89lipopolysaccharide-mediated signaling pathway (GO:0031663)2.99468690
90tRNA methylation (GO:0030488)2.99099554
91DNA strand elongation involved in DNA replication (GO:0006271)2.98706697
92dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.97857441
93cellular response to ethanol (GO:0071361)2.93416129
94kinetochore assembly (GO:0051382)2.92031004
95transcription from RNA polymerase I promoter (GO:0006360)2.91232591
96germinal center formation (GO:0002467)2.90338290
97DNA strand elongation (GO:0022616)2.89247708
98nuclear pore complex assembly (GO:0051292)2.89201188
99detection of bacterium (GO:0016045)2.89192005
100regulation of nuclear cell cycle DNA replication (GO:0033262)2.88987098
101mitotic recombination (GO:0006312)2.87905813
102SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.87252145
103nucleobase biosynthetic process (GO:0046112)2.86209829
104telomere maintenance via telomere lengthening (GO:0010833)2.84454359
105positive regulation of mast cell activation involved in immune response (GO:0033008)2.84278936
106positive regulation of mast cell degranulation (GO:0043306)2.84278936
107protein heterotetramerization (GO:0051290)2.83377734
108cotranslational protein targeting to membrane (GO:0006613)2.83020461
109tRNA modification (GO:0006400)2.82447278
1107-methylguanosine mRNA capping (GO:0006370)2.81266561
111definitive hemopoiesis (GO:0060216)2.81234344
112regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.81138678
113regulation of macrophage cytokine production (GO:0010935)2.79983294
114protein targeting to ER (GO:0045047)2.79891878
115lymphoid progenitor cell differentiation (GO:0002320)2.78874817
1167-methylguanosine RNA capping (GO:0009452)2.78461352
117RNA capping (GO:0036260)2.78461352
118negative regulation of metanephros development (GO:0072217)2.78303028
119positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78294250
120GDP-mannose metabolic process (GO:0019673)2.77880541
121respiratory burst (GO:0045730)2.76672759
122translational initiation (GO:0006413)2.75682434
123maturation of 5.8S rRNA (GO:0000460)2.73731485
124pinocytosis (GO:0006907)2.73367890
125positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.72775387
126sphingoid metabolic process (GO:0046519)2.72508854
127mature B cell differentiation (GO:0002335)2.71131555
128iron ion import (GO:0097286)2.70693519
129DNA ligation (GO:0006266)2.70583525
130myeloid leukocyte mediated immunity (GO:0002444)2.68948471
131protein localization to endoplasmic reticulum (GO:0070972)2.68530899
132positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.67236636
133positive regulation of interferon-alpha production (GO:0032727)2.67166041
134response to laminar fluid shear stress (GO:0034616)2.66489907
135positive regulation of B cell differentiation (GO:0045579)2.65992784
136positive regulation of granulocyte differentiation (GO:0030854)2.65881683
137RNA methylation (GO:0001510)2.65783894
138establishment of protein localization to endoplasmic reticulum (GO:0072599)2.65710098
139T-helper 1 type immune response (GO:0042088)2.65473197
140cellular component biogenesis (GO:0044085)2.65227683
141T cell migration (GO:0072678)2.63720587
142GPI anchor biosynthetic process (GO:0006506)2.63515885
143protein K6-linked ubiquitination (GO:0085020)2.63492947
144DNA damage response, detection of DNA damage (GO:0042769)2.63175430
145DNA-dependent DNA replication (GO:0006261)2.63135963
146keratinocyte development (GO:0003334)2.62587162
147production of molecular mediator involved in inflammatory response (GO:0002532)2.62180159
148regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.61769651
149oligosaccharide catabolic process (GO:0009313)2.61442573
150regulation of pigment cell differentiation (GO:0050932)2.60988826
151negative thymic T cell selection (GO:0045060)2.60957935
152guanosine-containing compound biosynthetic process (GO:1901070)2.60590607
153regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60485415
154phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.60016616
155negative regulation of interleukin-17 production (GO:0032700)2.59949188
156superoxide anion generation (GO:0042554)2.59706979
157positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.58908234
158negative regulation of DNA-dependent DNA replication (GO:2000104)2.58585513
159cellular response to thyroid hormone stimulus (GO:0097067)2.58298668
160regulation of regulated secretory pathway (GO:1903305)2.57853082
161DNA integration (GO:0015074)2.57597097
162spliceosomal snRNP assembly (GO:0000387)2.56643021
163regulation of necroptotic process (GO:0060544)2.56065895
164positive regulation of tumor necrosis factor production (GO:0032760)2.54965138
165positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54469078
166myeloid cell development (GO:0061515)2.54374529
167exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.52956601
168facial nerve structural organization (GO:0021612)2.52330938
169negative regulation of T cell mediated immunity (GO:0002710)2.51947247
170immunoglobulin mediated immune response (GO:0016064)2.51791823
171antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51447531
172positive regulation of macrophage cytokine production (GO:0060907)2.51293614
173leukocyte degranulation (GO:0043299)2.50848087
174centriole assembly (GO:0098534)2.49458498
175kinetochore organization (GO:0051383)2.48966543
176C-terminal protein lipidation (GO:0006501)2.48606494
177negative T cell selection (GO:0043383)2.48397176
178vitamin transmembrane transport (GO:0035461)2.48019554
179G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.47963422
180leukocyte aggregation (GO:0070486)2.47937215
181regulation of interferon-alpha production (GO:0032647)2.47933556
182cytochrome complex assembly (GO:0017004)2.47474796
183postsynaptic membrane organization (GO:0001941)2.47444397
184dosage compensation (GO:0007549)2.47428091
185translational elongation (GO:0006414)2.45843357
186mesonephros development (GO:0001823)2.45828268
187deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.45822951
188antigen processing and presentation of endogenous antigen (GO:0019883)2.45429356
189transcription initiation from RNA polymerase I promoter (GO:0006361)2.44650469
190myeloid leukocyte activation (GO:0002274)2.44568452
191DNA-templated transcription, elongation (GO:0006354)2.43944986
192translation (GO:0006412)2.43190376
193ncRNA processing (GO:0034470)2.43019802
194mannosylation (GO:0097502)2.42490526
195endothelium development (GO:0003158)2.40561824
196nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39531289
197cellular protein complex disassembly (GO:0043624)2.39503288
198RNA modification (GO:0009451)2.39418052
199mitochondrion degradation (GO:0000422)2.38904179
200nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.38607371

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.21373722
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.80465676
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.51663826
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.02368022
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.73569769
6GATA1_22025678_ChIP-Seq_K562_Human3.54145173
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.45478180
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.42456332
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.35533866
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.32372397
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.21117848
12NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.17843772
13NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.13979830
14MYC_18555785_ChIP-Seq_MESCs_Mouse3.11849168
15GABP_17652178_ChIP-ChIP_JURKAT_Human3.02516034
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.85264511
17STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.75358146
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.75290053
19Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.73979389
20NOTCH1_21737748_ChIP-Seq_TLL_Human2.68166900
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67589416
22ETS1_20019798_ChIP-Seq_JURKAT_Human2.67116560
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.62789274
24MYC_22102868_ChIP-Seq_BL_Human2.55658651
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.52981829
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.46369747
27BRD4_27068464_Chip-Seq_AML-cells_Mouse2.38016249
28VDR_21846776_ChIP-Seq_THP-1_Human2.32726945
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.31866823
30VDR_23849224_ChIP-Seq_CD4+_Human2.25883171
31RUNX_20019798_ChIP-Seq_JUKART_Human2.20558877
32* VDR_24763502_ChIP-Seq_THP-1_Human2.18543825
33* SPI1_23127762_ChIP-Seq_K562_Human2.16845624
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.15256079
35NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.11166006
36EZH2_22144423_ChIP-Seq_EOC_Human2.11053808
37MYC_19030024_ChIP-ChIP_MESCs_Mouse2.10230018
38PCGF2_27294783_Chip-Seq_ESCs_Mouse2.08044386
39TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.07149547
40MYB_26560356_Chip-Seq_TH2_Human2.06399422
41MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05970149
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.05588227
43FLI1_27457419_Chip-Seq_LIVER_Mouse2.00873781
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.00163276
45FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99480582
46FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.99085749
47BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.98428445
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.98206452
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97564332
50TCF7_22412390_ChIP-Seq_EML_Mouse1.97559449
51MAF_26560356_Chip-Seq_TH1_Human1.96646316
52IRF1_19129219_ChIP-ChIP_H3396_Human1.95676810
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.92783263
54MYB_26560356_Chip-Seq_TH1_Human1.91639224
55GATA1_19941826_ChIP-Seq_K562_Human1.90922565
56RUNX1_22412390_ChIP-Seq_EML_Mouse1.88966527
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.87480597
58TP63_19390658_ChIP-ChIP_HaCaT_Human1.82214270
59FOXP3_21729870_ChIP-Seq_TREG_Human1.77581380
60CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.77429619
61GATA1_19941827_ChIP-Seq_MEL_Mouse1.70323114
62RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.68723417
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66205190
64PU_27001747_Chip-Seq_BMDM_Mouse1.63518603
65IRF8_21731497_ChIP-ChIP_J774_Mouse1.61176643
66GATA2_19941826_ChIP-Seq_K562_Human1.58610335
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.58189616
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56891608
69TFEB_21752829_ChIP-Seq_HELA_Human1.56602867
70HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.56313471
71ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55928978
72KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.55469786
73KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.55469786
74KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.55469786
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.55233026
76UTX_26944678_Chip-Seq_JUKART_Human1.55102024
77SRF_21415370_ChIP-Seq_HL-1_Mouse1.53120742
78KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.52958605
79MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.52394184
80FOXM1_23109430_ChIP-Seq_U2OS_Human1.52331898
81TTF2_22483619_ChIP-Seq_HELA_Human1.51174951
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50476974
83ELK1_19687146_ChIP-ChIP_HELA_Human1.49810008
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.49748363
85* SPI1_23547873_ChIP-Seq_NB4_Human1.49398289
86FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48127809
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46289693
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.45719574
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44713084
90VDR_24787735_ChIP-Seq_THP-1_Human1.44592019
91GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43301788
92GATA2_21666600_ChIP-Seq_HMVEC_Human1.42835673
93GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40004959
94ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39111110
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38651085
96EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38332322
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.37908950
98MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.37676638
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37112790
100SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.36805584
101IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33862691
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33821816
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32652718
104E2F1_18555785_ChIP-Seq_MESCs_Mouse1.29174684
105KAP1_22055183_ChIP-Seq_ESCs_Mouse1.29114616
106GATA1_22383799_ChIP-Seq_G1ME_Mouse1.28168462
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28081207
108KDM2B_26808549_Chip-Seq_DND41_Human1.27531356
109ELK3_25401928_ChIP-Seq_HUVEC_Human1.26250497
110* ELK1_22589737_ChIP-Seq_MCF10A_Human1.25244919
111GATA3_27048872_Chip-Seq_THYMUS_Human1.24376689
112FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.24147651
113DCP1A_22483619_ChIP-Seq_HELA_Human1.23769643
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23644585
115THAP11_20581084_ChIP-Seq_MESCs_Mouse1.21802597
116CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.21770758
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.21384764
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.21384764
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.20567813
120NCOR1_26117541_ChIP-Seq_K562_Human1.19922664
121BP1_19119308_ChIP-ChIP_Hs578T_Human1.18001692
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17188211
123XRN2_22483619_ChIP-Seq_HELA_Human1.15863774
124NELFA_20434984_ChIP-Seq_ESCs_Mouse1.14515423
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.14159350
126MAF_26560356_Chip-Seq_TH2_Human1.13842022
127IGF1R_20145208_ChIP-Seq_DFB_Human1.13174550
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12777089
129GABP_19822575_ChIP-Seq_HepG2_Human1.12077154
130PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12056945
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09501389
132ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.07603619
133POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.07261664
134MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07006313
135KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.06678796
136RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05879616
137SCL_19346495_ChIP-Seq_HPC-7_Human1.04292857
138FOXO3_23340844_ChIP-Seq_DLD1_Human1.03417206
139LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.01975665
140KDM2B_26808549_Chip-Seq_JURKAT_Human1.01239681
141EZH2_27294783_Chip-Seq_NPCs_Mouse1.00863110
142RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00217002
143CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99247742
144STAT4_19710469_ChIP-ChIP_TH1__Mouse0.98977953
145KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96587231
146MYC_18940864_ChIP-ChIP_HL60_Human0.96249521
147E2F1_21310950_ChIP-Seq_MCF-7_Human0.95483687
148LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.94777896
149TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93915864
150MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93367145
151IRF8_22096565_ChIP-ChIP_GC-B_Human0.90696577
152MYCN_18555785_ChIP-Seq_MESCs_Mouse0.90472323
153ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89878545
154RUNX1_27457419_Chip-Seq_LIVER_Mouse0.89335162
155FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89279778
156GATA1_19941827_ChIP-Seq_MEL86_Mouse0.88843181
157FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.88516669
158ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87845456
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86741629
160IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86656818
161GATA3_26560356_Chip-Seq_TH2_Human0.86450520
162RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86442999
163NMYC_18555785_Chip-Seq_ESCs_Mouse0.86283603
164SALL4_18804426_ChIP-ChIP_XEN_Mouse0.86090041
165CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84756218
166SOX9_24532713_ChIP-Seq_HFSC_Mouse0.84018674
167GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82861416
168STAT3_18555785_Chip-Seq_ESCs_Mouse0.82567223
169GATA3_21867929_ChIP-Seq_CD8_Mouse0.82504291
170EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.80557130
171KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78069317
172LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78064165
173STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.76634713
174CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.75185566
175SUZ12_18555785_Chip-Seq_ESCs_Mouse0.74283393
176SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72566989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.92964841
2MP0001188_hyperpigmentation3.79086320
3MP0005409_darkened_coat_color3.59079782
4MP0004381_abnormal_hair_follicle3.58830624
5MP0009379_abnormal_foot_pigmentation3.57388014
6MP0008260_abnormal_autophagy3.47661622
7MP0003693_abnormal_embryo_hatching3.29386875
8MP0006292_abnormal_olfactory_placode3.27629971
9MP0000015_abnormal_ear_pigmentation2.92110213
10MP0005174_abnormal_tail_pigmentation2.89684141
11MP0005464_abnormal_platelet_physiology2.72554712
12MP0003718_maternal_effect2.50244465
13MP0003724_increased_susceptibility_to2.44064071
14MP0003172_abnormal_lysosome_physiology2.41706234
15MP0003656_abnormal_erythrocyte_physiolo2.39535989
16MP0003191_abnormal_cellular_cholesterol2.30577993
17MP0003300_gastrointestinal_ulcer2.24876456
18MP0003111_abnormal_nucleus_morphology2.12093751
19MP0010352_gastrointestinal_tract_polyps2.08881797
20MP0000569_abnormal_digit_pigmentation2.08070519
21MP0005075_abnormal_melanosome_morpholog2.06602741
22MP0008057_abnormal_DNA_replication2.03472526
23MP0009333_abnormal_splenocyte_physiolog2.03432923
24MP0008058_abnormal_DNA_repair1.98591703
25MP0004947_skin_inflammation1.95990132
26MP0010094_abnormal_chromosome_stability1.94229182
27MP0005076_abnormal_cell_differentiation1.89763422
28MP0001986_abnormal_taste_sensitivity1.88857985
29MP0003786_premature_aging1.86886387
30MP0004808_abnormal_hematopoietic_stem1.78800768
31MP0005671_abnormal_response_to1.71865588
32MP0003938_abnormal_ear_development1.70494758
33MP0000490_abnormal_crypts_of1.70076488
34MP0003091_abnormal_cell_migration1.68038184
35MP0002877_abnormal_melanocyte_morpholog1.66292567
36MP0002102_abnormal_ear_morphology1.63764867
37MP0002095_abnormal_skin_pigmentation1.63660177
38MP0000372_irregular_coat_pigmentation1.59270618
39MP0009278_abnormal_bone_marrow1.56975629
40MP0003941_abnormal_skin_development1.55687848
41MP0002998_abnormal_bone_remodeling1.54923795
42MP0003077_abnormal_cell_cycle1.54566379
43MP0004957_abnormal_blastocyst_morpholog1.52237136
44MP0002277_abnormal_respiratory_mucosa1.51943994
45MP0005451_abnormal_body_composition1.51025716
46MP0002876_abnormal_thyroid_physiology1.50928476
47MP0002396_abnormal_hematopoietic_system1.50565925
48MP0006082_CNS_inflammation1.49722109
49MP0003566_abnormal_cell_adhesion1.49048342
50MP0002009_preneoplasia1.47853894
51MP0002148_abnormal_hypersensitivity_rea1.47590031
52MP0003315_abnormal_perineum_morphology1.45770297
53MP0003763_abnormal_thymus_physiology1.44299630
54MP0001533_abnormal_skeleton_physiology1.42281022
55MP0001835_abnormal_antigen_presentation1.41172751
56MP0009785_altered_susceptibility_to1.34808335
57MP0009840_abnormal_foam_cell1.32254329
58MP0005000_abnormal_immune_tolerance1.28362624
59MP0001845_abnormal_inflammatory_respons1.27969869
60MP0002132_abnormal_respiratory_system1.27759620
61MP0005377_hearing/vestibular/ear_phenot1.27235873
62MP0003878_abnormal_ear_physiology1.27235873
63MP0000465_gastrointestinal_hemorrhage1.27122109
64MP0010155_abnormal_intestine_physiology1.26486600
65MP0005025_abnormal_response_to1.26295382
66MP0003453_abnormal_keratinocyte_physiol1.24733314
67MP0003303_peritoneal_inflammation1.22259901
68MP0003880_abnormal_central_pattern1.21666771
69MP0008932_abnormal_embryonic_tissue1.20561222
70MP0005310_abnormal_salivary_gland1.19415410
71MP0009764_decreased_sensitivity_to1.19320334
72MP0002723_abnormal_immune_serum1.16597733
73MP0004510_myositis1.16397193
74MP0002163_abnormal_gland_morphology1.16293601
75MP0001851_eye_inflammation1.15297770
76MP0003221_abnormal_cardiomyocyte_apopto1.14967400
77MP0002177_abnormal_outer_ear1.13983330
78MP0002419_abnormal_innate_immunity1.13381144
79MP0000681_abnormal_thyroid_gland1.12845269
80MP0008007_abnormal_cellular_replicative1.11002037
81MP0002420_abnormal_adaptive_immunity1.10198161
82MP0001819_abnormal_immune_cell1.10137597
83MP0004883_abnormal_blood_vessel1.09187682
84MP0008004_abnormal_stomach_pH1.08489752
85MP0000566_synostosis1.07882995
86MP0004233_abnormal_muscle_weight1.07427003
87MP0005621_abnormal_cell_physiology1.07151493
88MP0002452_abnormal_antigen_presenting1.06971356
89MP0001800_abnormal_humoral_immune1.06799823
90MP0003705_abnormal_hypodermis_morpholog1.04282807
91MP0003436_decreased_susceptibility_to1.03536725
92MP0003828_pulmonary_edema1.02300643
93MP0005164_abnormal_response_to1.01203523
94MP0002638_abnormal_pupillary_reflex1.00088501
95MP0002160_abnormal_reproductive_system0.99922129
96MP0003448_altered_tumor_morphology0.98209437
97MP0003183_abnormal_peptide_metabolism0.97405725
98MP0002398_abnormal_bone_marrow0.96510379
99MP0000604_amyloidosis0.95906285
100MP0000716_abnormal_immune_system0.95793830
101MP0001915_intracranial_hemorrhage0.95725398
102MP0008469_abnormal_protein_level0.94968177
103MP0001661_extended_life_span0.94466495
104MP0001853_heart_inflammation0.92725224
105MP0000689_abnormal_spleen_morphology0.92626036
106MP0008995_early_reproductive_senescence0.92223637
107MP0002722_abnormal_immune_system0.92074748
108MP0001919_abnormal_reproductive_system0.91820686
109MP0002751_abnormal_autonomic_nervous0.91495220
110MP0004185_abnormal_adipocyte_glucose0.90854306
111MP0005083_abnormal_biliary_tract0.90074880
112MP0000613_abnormal_salivary_gland0.89819416
113MP0003690_abnormal_glial_cell0.89268912
114MP0003075_altered_response_to0.89197779
115MP0000049_abnormal_middle_ear0.88688583
116MP0010307_abnormal_tumor_latency0.86488931
117MP0002332_abnormal_exercise_endurance0.84614756
118MP0004264_abnormal_extraembryonic_tissu0.82370302
119MP0002210_abnormal_sex_determination0.82027083
120MP0009763_increased_sensitivity_to0.81838382
121MP0000371_diluted_coat_color0.81238401
122MP0000343_altered_response_to0.81100827
123MP0000249_abnormal_blood_vessel0.80658139
124MP0005379_endocrine/exocrine_gland_phen0.79531292
125MP0001542_abnormal_bone_strength0.79302820
126MP0003646_muscle_fatigue0.79111828
127MP0002429_abnormal_blood_cell0.78837906
128MP0001790_abnormal_immune_system0.78220654
129MP0005387_immune_system_phenotype0.78220654
130MP0003879_abnormal_hair_cell0.76048202
131MP0002019_abnormal_tumor_incidence0.75780997
132MP0005257_abnormal_intraocular_pressure0.75074664
133MP0005384_cellular_phenotype0.74414542
134MP0009115_abnormal_fat_cell0.73414888
135MP0004130_abnormal_muscle_cell0.72298943
136MP0005023_abnormal_wound_healing0.72263311
137MP0005389_reproductive_system_phenotype0.71981988
138MP0005397_hematopoietic_system_phenotyp0.71706489
139MP0001545_abnormal_hematopoietic_system0.71706489
140MP0002006_tumorigenesis0.71606113
141MP0002938_white_spotting0.71448386
142MP0000685_abnormal_immune_system0.70896477
143MP0000858_altered_metastatic_potential0.69337553
144MP0002796_impaired_skin_barrier0.68623906
145MP0003795_abnormal_bone_structure0.67312259
146MP0000026_abnormal_inner_ear0.66832389
147MP0002166_altered_tumor_susceptibility0.66021597
148MP0005171_absent_coat_pigmentation0.64661510
149MP0002405_respiratory_system_inflammati0.63974369
150MP0000703_abnormal_thymus_morphology0.63599371
151MP0005058_abnormal_lysosome_morphology0.63270226
152MP0005395_other_phenotype0.63101565
153MP0001186_pigmentation_phenotype0.63043835
154MP0004742_abnormal_vestibular_system0.62093239
155MP0003866_abnormal_defecation0.61743801

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)5.29627523
2Type I transferrin isoform profile (HP:0003642)5.18031443
3Recurrent bacterial skin infections (HP:0005406)4.58224774
4Eczematoid dermatitis (HP:0000976)4.51926705
5Abnormality of macrophages (HP:0004311)3.97971807
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.68974223
7Abnormality of the axillary hair (HP:0100134)3.64848525
8Abnormality of secondary sexual hair (HP:0009888)3.64848525
9Spontaneous hematomas (HP:0007420)3.52275729
10Abnormal protein glycosylation (HP:0012346)3.45081314
11Abnormal glycosylation (HP:0012345)3.45081314
12Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.45081314
13Abnormal protein N-linked glycosylation (HP:0012347)3.45081314
14Prolonged bleeding time (HP:0003010)3.42895047
15Reticulocytopenia (HP:0001896)3.37188300
16Gingival bleeding (HP:0000225)3.32419119
17Chromsome breakage (HP:0040012)3.28566208
18Increased cerebral lipofuscin (HP:0011813)3.20802116
19Abnormal number of erythroid precursors (HP:0012131)3.19770914
20Epistaxis (HP:0000421)3.13827092
21Abnormality of cells of the erythroid lineage (HP:0012130)3.12018358
22Abnormal platelet volume (HP:0011876)3.06018359
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.05226214
24Abnormality of the preputium (HP:0100587)3.04619561
25Recurrent fungal infections (HP:0002841)3.03979556
26T lymphocytopenia (HP:0005403)3.03815846
27Recurrent skin infections (HP:0001581)3.03316020
28Absent rod-and cone-mediated responses on ERG (HP:0007688)3.01488335
29Orchitis (HP:0100796)3.00714971
30Myositis (HP:0100614)2.95580708
31Obstructive lung disease (HP:0006536)2.95120264
32Chronic obstructive pulmonary disease (HP:0006510)2.95120264
33Myocardial infarction (HP:0001658)2.86365344
34Increased mean platelet volume (HP:0011877)2.85672830
35Optic neuritis (HP:0100653)2.84269206
36Retrobulbar optic neuritis (HP:0100654)2.84269206
37Recurrent viral infections (HP:0004429)2.82491966
38Meckel diverticulum (HP:0002245)2.78857453
39Increased neuronal autofluorescent lipopigment (HP:0002074)2.75534583
40Abnormality of T cell number (HP:0011839)2.74263453
41Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.66375829
42Abnormality of liposaccharide metabolism (HP:0010968)2.66020728
43Abnormality of glycosphingolipid metabolism (HP:0004343)2.66020728
44Abnormality of glycolipid metabolism (HP:0010969)2.66020728
45Breast hypoplasia (HP:0003187)2.64199997
46Gingivitis (HP:0000230)2.64178940
47Abnormality of the ileum (HP:0001549)2.61641380
48Macrocytic anemia (HP:0001972)2.60168440
49Stomatitis (HP:0010280)2.58990901
50Recurrent gram-negative bacterial infections (HP:0005420)2.58901487
51Aplasia/Hypoplasia of the uvula (HP:0010293)2.58854494
52Subacute progressive viral hepatitis (HP:0006572)2.57853283
53Fatigue (HP:0012378)2.55647557
54Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52939119
55Abnormality of the fingertips (HP:0001211)2.50975264
56Arterial thrombosis (HP:0004420)2.50258361
57Sex reversal (HP:0012245)2.49376158
58Abnormal sex determination (HP:0012244)2.49376158
59Gastrointestinal infarctions (HP:0005244)2.49330266
60Menorrhagia (HP:0000132)2.46011996
613-Methylglutaconic aciduria (HP:0003535)2.44551424
62Cellulitis (HP:0100658)2.44250770
63Rough bone trabeculation (HP:0100670)2.42693269
64Abnormality of the prostate (HP:0008775)2.40896123
65Autoimmune thrombocytopenia (HP:0001973)2.40015995
66Abnormality of chromosome stability (HP:0003220)2.38339769
67Clubbing of toes (HP:0100760)2.36762041
68Osteolytic defects of the hand bones (HP:0009699)2.35469754
69Osteolytic defects of the phalanges of the hand (HP:0009771)2.35469754
70Aplasia/Hypoplasia of the sacrum (HP:0008517)2.35005566
71Viral hepatitis (HP:0006562)2.34652710
72Thyroid-stimulating hormone excess (HP:0002925)2.33263607
73Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.32540362
74Impulsivity (HP:0100710)2.32324570
75Abnormal delayed hypersensitivity skin test (HP:0002963)2.30023245
76Colitis (HP:0002583)2.29828197
77Exertional dyspnea (HP:0002875)2.28882948
78Increased hepatocellular lipid droplets (HP:0006565)2.27906442
79Vasculitis (HP:0002633)2.27315392
80Recurrent abscess formation (HP:0002722)2.25688475
81Birth length less than 3rd percentile (HP:0003561)2.25298819
82Slow saccadic eye movements (HP:0000514)2.25102247
83Capillary hemangiomas (HP:0005306)2.23392819
84Elevated erythrocyte sedimentation rate (HP:0003565)2.23389320
85Urticaria (HP:0001025)2.23192729
86Papillary thyroid carcinoma (HP:0002895)2.22944933
87Prolonged neonatal jaundice (HP:0006579)2.21967385
88Cheilitis (HP:0100825)2.21931545
89Abnormal platelet function (HP:0011869)2.20974053
90Impaired platelet aggregation (HP:0003540)2.20974053
91Autoimmune hemolytic anemia (HP:0001890)2.20082697
92Pallor (HP:0000980)2.19885310
93Osteomyelitis (HP:0002754)2.19659651
94Acute myeloid leukemia (HP:0004808)2.19588146
95Split foot (HP:0001839)2.19339114
96Chest pain (HP:0100749)2.18923547
97Bone marrow hypocellularity (HP:0005528)2.18227158
98Keratoconjunctivitis sicca (HP:0001097)2.17008859
99Syringomyelia (HP:0003396)2.16461114
100Spinal cord lesions (HP:0100561)2.16461114
101Dysostosis multiplex (HP:0000943)2.15946090
102Amyloidosis (HP:0011034)2.13601021
103Hypoplasia of the radius (HP:0002984)2.13019582
104Aplastic anemia (HP:0001915)2.11650362
105Triphalangeal thumb (HP:0001199)2.11281283
106Parakeratosis (HP:0001036)2.10611385
107Prostate neoplasm (HP:0100787)2.09615067
108Type 2 muscle fiber atrophy (HP:0003554)2.09483641
109Inflammation of the large intestine (HP:0002037)2.09307349
110Purpura (HP:0000979)2.09261602
111Duplicated collecting system (HP:0000081)2.08268232
112Entropion (HP:0000621)2.07152840
113Pancreatic fibrosis (HP:0100732)2.07089817
114Concave nail (HP:0001598)2.06693821
115Microvesicular hepatic steatosis (HP:0001414)2.06286877
116Abnormal trabecular bone morphology (HP:0100671)2.03698440
117Nonprogressive disorder (HP:0003680)2.03250907
118Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03172751
119Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02703129
120Attenuation of retinal blood vessels (HP:0007843)2.00432425
121Abnormality of T cells (HP:0002843)2.00068710
122Leukocytosis (HP:0001974)1.98685436
123Abnormality of the columella (HP:0009929)1.98339916
124Periodontitis (HP:0000704)1.98233579
125Polycythemia (HP:0001901)1.98229241
126Petechiae (HP:0000967)1.98092616
127Pustule (HP:0200039)1.98049907
128Absent thumb (HP:0009777)1.97927843
129Encephalitis (HP:0002383)1.97890645
130Vacuolated lymphocytes (HP:0001922)1.97401012
131Amaurosis fugax (HP:0100576)1.96975787
132Abnormal spermatogenesis (HP:0008669)1.96454458
133Gastrointestinal inflammation (HP:0004386)1.96360090
134Congenital, generalized hypertrichosis (HP:0004540)1.94485153
135Hypothermia (HP:0002045)1.94263394
136Muscle fiber atrophy (HP:0100295)1.92613380
137Increased IgE level (HP:0003212)1.92557960
138Anhidrosis (HP:0000970)1.91999720
139Abnormality of the renal collecting system (HP:0004742)1.91490386
140Sparse lateral eyebrow (HP:0005338)1.91005571
141Absent radius (HP:0003974)1.90847650
142Renal Fanconi syndrome (HP:0001994)1.90705044
143IgM deficiency (HP:0002850)1.90314057
144Progressive muscle weakness (HP:0003323)1.89559752
145Meningitis (HP:0001287)1.89207462
146Pancytopenia (HP:0001876)1.88442816
147Thrombocytosis (HP:0001894)1.87754759
148Abnormality of dental color (HP:0011073)1.87279683
149Loss of speech (HP:0002371)1.86547710
150Conjunctival telangiectasia (HP:0000524)1.85899460
151Abnormality of magnesium homeostasis (HP:0004921)1.85051358
152Deep philtrum (HP:0002002)1.84770209
153Abnormal rod and cone electroretinograms (HP:0008323)1.84471723
154Keratoconjunctivitis (HP:0001096)1.84110085
155Poikilocytosis (HP:0004447)1.83102955
156Distal lower limb amyotrophy (HP:0008944)1.83097383
157Aplasia involving forearm bones (HP:0009822)1.82975116
158Absent forearm bone (HP:0003953)1.82975116
159Mucopolysacchariduria (HP:0008155)1.82867936
160Urinary glycosaminoglycan excretion (HP:0003541)1.82867936
161Abnormality of male internal genitalia (HP:0000022)1.82514232
162Small intestinal stenosis (HP:0012848)1.82154315
163Duodenal stenosis (HP:0100867)1.82154315
164Azoospermia (HP:0000027)1.81766590
165Mediastinal lymphadenopathy (HP:0100721)1.79358191
166Acute hepatic failure (HP:0006554)1.79170565
167Peritonitis (HP:0002586)1.78932540
168Dry hair (HP:0011359)1.78297919
169Pulmonary infiltrates (HP:0002113)1.77871934
170IgG deficiency (HP:0004315)1.77791770
171Ectopic kidney (HP:0000086)1.77313293
172Abnormality of DNA repair (HP:0003254)1.76932936
173Broad face (HP:0000283)1.75631982
174Coarse hair (HP:0002208)1.75540647
175Dysmetric saccades (HP:0000641)1.75422483
176Recurrent cutaneous fungal infections (HP:0011370)1.75322688
177Chronic mucocutaneous candidiasis (HP:0002728)1.75322688
178Sparse eyelashes (HP:0000653)1.73937844
179Microcytic anemia (HP:0001935)1.73595902
180Micronodular cirrhosis (HP:0001413)1.73395662
181Aplasia/hypoplasia of the uterus (HP:0008684)1.73385637
182Granulocytopenia (HP:0001913)1.73329121
183Severe visual impairment (HP:0001141)1.73308095
184True hermaphroditism (HP:0010459)1.73182903
185Abnormality of the common coagulation pathway (HP:0010990)1.72676885
186Hemoptysis (HP:0002105)1.72530272
187Premature graying of hair (HP:0002216)1.72124315

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNIK4.10286755
2EIF2AK34.08479364
3STK163.71218770
4MKNK23.37054461
5CDK123.36167362
6CASK3.32063477
7BUB13.23866960
8NME23.21379807
9IRAK32.98681737
10WEE12.61772164
11MUSK2.47724093
12MAP2K32.41538633
13NLK2.40092617
14SRPK12.33653553
15MKNK12.24706938
16IRAK42.20924126
17CLK12.16744133
18AKT32.11106374
19EIF2AK22.06110631
20ERN11.95957438
21TLK11.95148006
22BLK1.89220584
23TYK21.73471450
24PIK3CG1.71820185
25PLK41.71210876
26CAMK1D1.68058078
27FES1.67964321
28ICK1.65789371
29WNK11.59247594
30NEK91.51522207
31PIM21.50818055
32JAK31.48035816
33ZAK1.46964052
34TAOK31.45603329
35CAMKK21.42493537
36VRK11.42024438
37TRPM71.41800466
38TEC1.41267904
39TXK1.40351832
40JAK11.36902961
41MAP3K11.33667696
42EIF2AK11.30262587
43YES11.24590706
44KSR21.23507329
45BRD41.21178900
46MAP3K21.20204158
47GRK61.20058843
48CDK61.19329253
49MAP3K31.16248584
50CAMK1G1.15998260
51JAK21.15947947
52SGK31.12156642
53STK101.10535178
54MAP3K131.07846628
55CSF1R1.07060990
56TBK11.03584516
57TRIB31.01228298
58DYRK31.00360053
59EPHB11.00017750
60SGK20.99869547
61TAOK10.99399304
62MARK20.98568885
63TAOK20.98274407
64CDK70.97857818
65IRAK20.97554995
66BRSK20.97392102
67IRAK10.97370488
68TTN0.97167753
69SMG10.96247477
70TSSK60.96217191
71CDK30.95021040
72RAF10.94865012
73EPHA20.91511833
74MAP3K60.91404101
75RIPK40.89749091
76IKBKB0.85921249
77ADRBK20.85160196
78MATK0.83355552
79MTOR0.82741008
80MAPK110.80321416
81PRKD20.79949318
82EEF2K0.78950463
83FGFR30.77410748
84PLK10.77045739
85ACVR1B0.77039530
86SCYL20.76421524
87GRK10.75954732
88TGFBR20.73859004
89KIT0.72563306
90CHUK0.70944110
91MAPK70.69887940
92PIM10.69798893
93CHEK20.68989779
94MAP4K10.68737359
95NEK20.67937434
96ITK0.67550095
97MELK0.66734316
98PDK10.65926312
99CSNK1G10.65415873
100TESK20.65230106
101PRPF4B0.63650383
102LYN0.62680334
103RET0.62286687
104GRK70.60058970
105HIPK20.60057539
106PDGFRB0.59143773
107ZAP700.59140994
108RPS6KA50.59099873
109PDPK10.58850151
110CAMK10.58227983
111CDC70.58026496
112STK380.57659149
113MAPK120.57111110
114FGFR40.54869688
115CDK40.54344574
116MARK30.54256025
117MAP2K70.54157137
118TTK0.53941453
119RPS6KL10.53494240
120RPS6KC10.53494240
121BTK0.52727899
122MST40.52243343
123MAP3K50.51919302
124IKBKE0.51619706
125MAP3K140.51571854
126AURKB0.51552396
127AURKA0.51484009
128MAP3K80.51023620
129CSK0.49259843
130PINK10.49013097
131FGR0.48416530
132SYK0.46461625
133KSR10.44671585
134BMPR20.44461671
135CDK80.42931546
136MAPK150.42325128
137LRRK20.42082907
138PTK2B0.42076885
139RPS6KA60.41948683
140CDK190.41559018
141CAMK40.41011086
142CSNK2A10.40780424
143PAK10.40753823
144BMPR1B0.40061269
145LCK0.37874726
146DYRK20.35916426
147CSNK2A20.35911367
148MAPK40.35570708
149ABL20.34123317
150NME10.33124880
151PLK30.32589785
152HCK0.32242955
153CSNK1G30.30406522
154PRKCI0.29253418
155PBK0.29012390
156ATR0.27425206
157BRAF0.25981427
158ABL10.25833457
159KDR0.25627664
160STK240.23867045
161MAP3K120.23291915
162NEK60.23003473
163CCNB10.22225450
164STK40.21507566
165STK30.21354473
166NUAK10.21148808

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030103.56945064
2RNA polymerase_Homo sapiens_hsa030203.38252680
3DNA replication_Homo sapiens_hsa030303.20652021
4Homologous recombination_Homo sapiens_hsa034402.94494573
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.84906008
6Fanconi anemia pathway_Homo sapiens_hsa034602.64384449
7Vitamin B6 metabolism_Homo sapiens_hsa007502.58467619
8Proteasome_Homo sapiens_hsa030502.35230096
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.28855825
10Pyrimidine metabolism_Homo sapiens_hsa002402.25182078
11B cell receptor signaling pathway_Homo sapiens_hsa046622.23044993
12Spliceosome_Homo sapiens_hsa030402.08845634
13Mismatch repair_Homo sapiens_hsa034302.08728456
14Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.07955987
15Basal transcription factors_Homo sapiens_hsa030222.03139105
16Base excision repair_Homo sapiens_hsa034102.00461955
17Non-small cell lung cancer_Homo sapiens_hsa052231.86050720
18Nucleotide excision repair_Homo sapiens_hsa034201.78034871
19Chronic myeloid leukemia_Homo sapiens_hsa052201.77970097
20Regulation of autophagy_Homo sapiens_hsa041401.77040129
21Other glycan degradation_Homo sapiens_hsa005111.72613678
22Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.68241757
23Folate biosynthesis_Homo sapiens_hsa007901.65516128
24Pancreatic cancer_Homo sapiens_hsa052121.64845425
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59756284
26Sphingolipid metabolism_Homo sapiens_hsa006001.58701941
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.58346339
28Protein export_Homo sapiens_hsa030601.58180778
29Platelet activation_Homo sapiens_hsa046111.54498954
30RNA transport_Homo sapiens_hsa030131.53705299
31Toxoplasmosis_Homo sapiens_hsa051451.53306608
32Purine metabolism_Homo sapiens_hsa002301.51818817
33Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.50431333
34Legionellosis_Homo sapiens_hsa051341.50021889
35Staphylococcus aureus infection_Homo sapiens_hsa051501.48668103
36p53 signaling pathway_Homo sapiens_hsa041151.45215347
37T cell receptor signaling pathway_Homo sapiens_hsa046601.42745322
38TNF signaling pathway_Homo sapiens_hsa046681.41775051
39Viral carcinogenesis_Homo sapiens_hsa052031.39292203
40Primary immunodeficiency_Homo sapiens_hsa053401.35768634
41Cell cycle_Homo sapiens_hsa041101.35334478
42Renal cell carcinoma_Homo sapiens_hsa052111.34638357
43Vitamin digestion and absorption_Homo sapiens_hsa049771.33226816
44Non-homologous end-joining_Homo sapiens_hsa034501.29733701
45Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28829221
46Arachidonic acid metabolism_Homo sapiens_hsa005901.26867125
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25023428
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.21327243
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.21311215
50Chemokine signaling pathway_Homo sapiens_hsa040621.20724392
51Endometrial cancer_Homo sapiens_hsa052131.20566497
52NF-kappa B signaling pathway_Homo sapiens_hsa040641.20086441
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.14239879
54Prolactin signaling pathway_Homo sapiens_hsa049171.12938754
55Hepatitis C_Homo sapiens_hsa051601.12303071
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.10508849
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10338410
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.09800628
59Allograft rejection_Homo sapiens_hsa053301.09482281
60Bladder cancer_Homo sapiens_hsa052191.06981369
61Graft-versus-host disease_Homo sapiens_hsa053321.06501027
62Dorso-ventral axis formation_Homo sapiens_hsa043201.05670942
63Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02692875
64Shigellosis_Homo sapiens_hsa051311.01738542
65Phagosome_Homo sapiens_hsa041451.01662016
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01164450
67VEGF signaling pathway_Homo sapiens_hsa043701.00372385
68Autoimmune thyroid disease_Homo sapiens_hsa053200.99671649
69RNA degradation_Homo sapiens_hsa030180.99573251
70Herpes simplex infection_Homo sapiens_hsa051680.99548869
71Asthma_Homo sapiens_hsa053100.99211949
72mTOR signaling pathway_Homo sapiens_hsa041500.98699093
73Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98380667
74Small cell lung cancer_Homo sapiens_hsa052220.98220288
75FoxO signaling pathway_Homo sapiens_hsa040680.97188832
76Hematopoietic cell lineage_Homo sapiens_hsa046400.96808975
77Measles_Homo sapiens_hsa051620.94485249
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.93513138
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92092395
80Colorectal cancer_Homo sapiens_hsa052100.88965339
81Viral myocarditis_Homo sapiens_hsa054160.87833842
82HIF-1 signaling pathway_Homo sapiens_hsa040660.86981572
83Notch signaling pathway_Homo sapiens_hsa043300.86591730
84Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86316802
85ErbB signaling pathway_Homo sapiens_hsa040120.85755856
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.85442381
87Epstein-Barr virus infection_Homo sapiens_hsa051690.85325506
88Ether lipid metabolism_Homo sapiens_hsa005650.84161693
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.83798498
90MicroRNAs in cancer_Homo sapiens_hsa052060.83351232
91Salmonella infection_Homo sapiens_hsa051320.82052164
92Phototransduction_Homo sapiens_hsa047440.80438330
93Amoebiasis_Homo sapiens_hsa051460.79962390
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.79679843
95Glioma_Homo sapiens_hsa052140.75656243
96Thyroid cancer_Homo sapiens_hsa052160.74716433
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.74090661
98N-Glycan biosynthesis_Homo sapiens_hsa005100.73894798
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.73769219
100Sulfur relay system_Homo sapiens_hsa041220.73728996
101Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73523828
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72592759
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72424320
104Pentose phosphate pathway_Homo sapiens_hsa000300.72013525
105Type II diabetes mellitus_Homo sapiens_hsa049300.71520296
106Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71445069
107Alcoholism_Homo sapiens_hsa050340.69705274
108HTLV-I infection_Homo sapiens_hsa051660.68819956
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67852683
110Insulin resistance_Homo sapiens_hsa049310.67331221
111One carbon pool by folate_Homo sapiens_hsa006700.66676687
112Choline metabolism in cancer_Homo sapiens_hsa052310.66377719
113Linoleic acid metabolism_Homo sapiens_hsa005910.65998005
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.65918834
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.65520785
116Proteoglycans in cancer_Homo sapiens_hsa052050.64876342
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64864712
118Malaria_Homo sapiens_hsa051440.64598166
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63623750
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.63575615
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.62730974
122Rheumatoid arthritis_Homo sapiens_hsa053230.62107023
123Antigen processing and presentation_Homo sapiens_hsa046120.62060096
124Endocytosis_Homo sapiens_hsa041440.57929547
125Leishmaniasis_Homo sapiens_hsa051400.57837063
126GnRH signaling pathway_Homo sapiens_hsa049120.56365133
127Oxidative phosphorylation_Homo sapiens_hsa001900.55595813
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54473642
129Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.53892199
130Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53485580
131Systemic lupus erythematosus_Homo sapiens_hsa053220.51860725
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.51699680
133Renin-angiotensin system_Homo sapiens_hsa046140.51604612
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.51444946
135Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51269149
136African trypanosomiasis_Homo sapiens_hsa051430.50884925
137Circadian rhythm_Homo sapiens_hsa047100.47467565
138Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47097553
139Metabolic pathways_Homo sapiens_hsa011000.40287394
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.39882789
141Lysosome_Homo sapiens_hsa041420.39785930
142Huntingtons disease_Homo sapiens_hsa050160.39616081
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37911768
144Glutathione metabolism_Homo sapiens_hsa004800.37673380
145alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36631105
146Acute myeloid leukemia_Homo sapiens_hsa052210.35684565
147Apoptosis_Homo sapiens_hsa042100.32112094
148Influenza A_Homo sapiens_hsa051640.31373749
149Toll-like receptor signaling pathway_Homo sapiens_hsa046200.31334487
150mRNA surveillance pathway_Homo sapiens_hsa030150.31331784
151Tuberculosis_Homo sapiens_hsa051520.30569018
152Nicotine addiction_Homo sapiens_hsa050330.29539312
153Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29197829
154Osteoclast differentiation_Homo sapiens_hsa043800.29062195
155Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.28442331
156Steroid hormone biosynthesis_Homo sapiens_hsa001400.26582118
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.24763594
158Hepatitis B_Homo sapiens_hsa051610.24422553
159Pertussis_Homo sapiens_hsa051330.23523294
160Prostate cancer_Homo sapiens_hsa052150.23480217
161Inositol phosphate metabolism_Homo sapiens_hsa005620.23296544
162Mineral absorption_Homo sapiens_hsa049780.22646553
163Wnt signaling pathway_Homo sapiens_hsa043100.21382319
164Glycosaminoglycan degradation_Homo sapiens_hsa005310.21235910

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