TMPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene resides in the nucleus and may play a role in the assembly of the nuclear lamina, and thus help maintain the structural organization of the nuclear envelope. It may function as a receptor for the attachment of lamin filaments to the inner nuclear membrane. Mutations in this gene are associated with dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)6.03098569
2DNA unwinding involved in DNA replication (GO:0006268)5.64741737
3regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.44828022
4protein localization to chromosome, centromeric region (GO:0071459)5.07638321
5mitotic chromosome condensation (GO:0007076)4.84969851
6sister chromatid segregation (GO:0000819)4.63851754
7mitotic sister chromatid cohesion (GO:0007064)4.59900436
8nuclear pore organization (GO:0006999)4.53947921
9nuclear pore complex assembly (GO:0051292)4.52346941
10DNA ligation (GO:0006266)4.50826500
11kinetochore organization (GO:0051383)4.45109015
12mitotic sister chromatid segregation (GO:0000070)4.26269285
13establishment of integrated proviral latency (GO:0075713)4.19140959
14DNA strand elongation involved in DNA replication (GO:0006271)4.14664204
15DNA topological change (GO:0006265)4.00481024
16DNA replication initiation (GO:0006270)3.99878952
17DNA strand elongation (GO:0022616)3.99685438
18CENP-A containing nucleosome assembly (GO:0034080)3.91612835
19mitotic nuclear envelope disassembly (GO:0007077)3.90981062
20double-strand break repair via nonhomologous end joining (GO:0006303)3.90647255
21non-recombinational repair (GO:0000726)3.90647255
22regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.89013100
23V(D)J recombination (GO:0033151)3.87997849
24chromatin remodeling at centromere (GO:0031055)3.86555721
25mitotic recombination (GO:0006312)3.84185466
26telomere maintenance via semi-conservative replication (GO:0032201)3.81638332
27DNA duplex unwinding (GO:0032508)3.81347221
28DNA geometric change (GO:0032392)3.80416625
29attachment of spindle microtubules to kinetochore (GO:0008608)3.79120751
30protein localization to chromosome (GO:0034502)3.77389111
31DNA replication-independent nucleosome assembly (GO:0006336)3.77161335
32DNA replication-independent nucleosome organization (GO:0034724)3.77161335
33DNA replication-dependent nucleosome organization (GO:0034723)3.75993520
34DNA replication-dependent nucleosome assembly (GO:0006335)3.75993520
35mitotic metaphase plate congression (GO:0007080)3.72505063
36regulation of sister chromatid cohesion (GO:0007063)3.71915852
37dosage compensation (GO:0007549)3.67443001
38nuclear envelope disassembly (GO:0051081)3.65327978
39membrane disassembly (GO:0030397)3.65327978
40microtubule depolymerization (GO:0007019)3.59763170
41telomere maintenance via recombination (GO:0000722)3.57921205
42metaphase plate congression (GO:0051310)3.54961543
43chromatin assembly or disassembly (GO:0006333)3.53176234
44regulation of histone H3-K9 methylation (GO:0051570)3.51672716
45negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50202272
46regulation of spindle organization (GO:0090224)3.48971831
47translesion synthesis (GO:0019985)3.48548435
48chromosome condensation (GO:0030261)3.45894748
49regulation of centrosome duplication (GO:0010824)3.45283975
50kinetochore assembly (GO:0051382)3.44968546
51regulation of DNA endoreduplication (GO:0032875)3.44862219
52meiotic chromosome segregation (GO:0045132)3.43895036
53pore complex assembly (GO:0046931)3.43451163
54mitotic G2/M transition checkpoint (GO:0044818)3.40703558
55DNA replication checkpoint (GO:0000076)3.39330954
56DNA synthesis involved in DNA repair (GO:0000731)3.38927932
57negative regulation of RNA splicing (GO:0033119)3.36003571
58chromatin assembly (GO:0031497)3.35963177
59positive regulation of chromosome segregation (GO:0051984)3.35953636
60regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.33245540
61DNA conformation change (GO:0071103)3.33211757
62positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.30557178
63positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.30557178
64positive regulation of mitotic sister chromatid separation (GO:1901970)3.30557178
65negative regulation of DNA repair (GO:0045738)3.29317796
66establishment of chromosome localization (GO:0051303)3.28357583
67regulation of RNA export from nucleus (GO:0046831)3.27925491
68histone exchange (GO:0043486)3.26302286
69ATP-dependent chromatin remodeling (GO:0043044)3.26256370
70spindle checkpoint (GO:0031577)3.21476026
71regulation of chromosome segregation (GO:0051983)3.21225177
72telomere maintenance via telomere lengthening (GO:0010833)3.17328370
73folic acid-containing compound biosynthetic process (GO:0009396)3.16873768
74negative regulation of histone methylation (GO:0031061)3.15579052
75chromosome segregation (GO:0007059)3.15555808
76IMP biosynthetic process (GO:0006188)3.15408986
77mitotic cell cycle (GO:0000278)3.14118987
78nucleotide-excision repair, DNA gap filling (GO:0006297)3.13573676
79negative regulation of mRNA processing (GO:0050686)3.09054206
80establishment of viral latency (GO:0019043)3.08518106
81positive regulation of cell cycle checkpoint (GO:1901978)3.08365057
82protein complex localization (GO:0031503)3.07780946
83sister chromatid cohesion (GO:0007062)3.07277045
84somatic cell DNA recombination (GO:0016444)3.05121105
85somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.05121105
86DNA packaging (GO:0006323)3.04452447
87regulation of mitotic spindle organization (GO:0060236)3.03722164
88ribosomal small subunit assembly (GO:0000028)3.03248552
89spindle assembly checkpoint (GO:0071173)3.03179560
90regulation of mitotic metaphase/anaphase transition (GO:0030071)3.02163594
91RNA stabilization (GO:0043489)3.00597771
92mRNA stabilization (GO:0048255)3.00597771
93histone-serine phosphorylation (GO:0035404)2.98267215
94mitotic spindle checkpoint (GO:0071174)2.97124252
95heterochromatin organization (GO:0070828)2.96598230
96postreplication repair (GO:0006301)2.95447468
97regulation of centrosome cycle (GO:0046605)2.94898219
98negative regulation of chromosome segregation (GO:0051985)2.94842313
993-UTR-mediated mRNA stabilization (GO:0070935)2.94255780
100regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94005845
101nuclear envelope organization (GO:0006998)2.90416077
102negative regulation of mitotic sister chromatid separation (GO:2000816)2.89879900
103negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89879900
104negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89879900
105negative regulation of sister chromatid segregation (GO:0033046)2.89879900
106mitotic spindle assembly checkpoint (GO:0007094)2.87596118
107regulation of centriole replication (GO:0046599)2.86353852
108regulation of mitotic sister chromatid separation (GO:0010965)2.84234135
109regulation of mitotic sister chromatid segregation (GO:0033047)2.84234135
110regulation of sister chromatid segregation (GO:0033045)2.84234135
111alternative mRNA splicing, via spliceosome (GO:0000380)2.84148784
112telomere maintenance (GO:0000723)2.83858324
113negative regulation of mRNA metabolic process (GO:1903312)2.80525513
114telomere organization (GO:0032200)2.79705430
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.79684099
116mitotic DNA integrity checkpoint (GO:0044774)2.76653061
117pre-miRNA processing (GO:0031054)2.74731727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* FOXM1_23109430_ChIP-Seq_U2OS_Human6.43475429
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.63794042
3* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.88756822
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.39859856
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.21616545
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86812448
7* E2F1_21310950_ChIP-Seq_MCF-7_Human2.53893782
8* AR_21909140_ChIP-Seq_LNCAP_Human2.50358857
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.49580108
10MYC_22102868_ChIP-Seq_BL_Human2.41601407
11* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33011065
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.26451475
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17860221
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06147180
15E2F7_22180533_ChIP-Seq_HELA_Human11.3950086
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.90147748
17* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89997592
18TP63_19390658_ChIP-ChIP_HaCaT_Human1.89756566
19XRN2_22483619_ChIP-Seq_HELA_Human1.83550589
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.81301437
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.81219616
22CIITA_25753668_ChIP-Seq_RAJI_Human1.77801744
23MYC_18358816_ChIP-ChIP_MESCs_Mouse1.76012920
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.63032265
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.62243830
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58774208
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58290395
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56344203
29SALL1_21062744_ChIP-ChIP_HESCs_Human1.51769599
30FOXP3_21729870_ChIP-Seq_TREG_Human1.51344894
31TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51218456
32* VDR_23849224_ChIP-Seq_CD4+_Human1.48721051
33* VDR_21846776_ChIP-Seq_THP-1_Human1.47803265
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.47755335
35CREB1_15753290_ChIP-ChIP_HEK293T_Human1.47063614
36KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46496174
37CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.45870490
38ELK1_19687146_ChIP-ChIP_HELA_Human1.44096764
39* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43485048
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.42230541
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40223237
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39431662
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39019196
44TTF2_22483619_ChIP-Seq_HELA_Human1.37086813
45KDM5A_27292631_Chip-Seq_BREAST_Human1.36311713
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.28058066
47DCP1A_22483619_ChIP-Seq_HELA_Human1.27730941
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.27042745
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22173440
50E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21959165
51CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21802802
52GABP_19822575_ChIP-Seq_HepG2_Human1.17998064
53MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.17924077
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17286392
55ERG_20887958_ChIP-Seq_HPC-7_Mouse1.17133782
56* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16880095
57FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15772332
58SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.15501840
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14707067
60GABP_17652178_ChIP-ChIP_JURKAT_Human1.13384740
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.11857335
62* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.09858266
63ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09787679
64SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.09755803
65* TCF7_22412390_ChIP-Seq_EML_Mouse1.08954479
66SCL_19346495_ChIP-Seq_HPC-7_Human1.06466207
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.06401938
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03829679
69* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.03058961
70TFEB_21752829_ChIP-Seq_HELA_Human1.02914899
71* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02858381
72CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.02346244
73PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01800070
74UTX_26944678_Chip-Seq_JUKART_Human1.01725651
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.01071351
76KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00155886
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99080388
78CHD1_26751641_Chip-Seq_LNCaP_Human0.98041482
79NANOG_16153702_ChIP-ChIP_HESCs_Human0.97632021
80* MYB_26560356_Chip-Seq_TH2_Human0.97624372
81NANOG_21062744_ChIP-ChIP_HESCs_Human0.97124997
82MAF_26560356_Chip-Seq_TH1_Human0.96457864
83POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95977334
84ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.95581214
85* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95284531
86* MYB_26560356_Chip-Seq_TH1_Human0.94279796
87THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93832202
88HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.93721023
89SOX17_20123909_ChIP-Seq_XEN_Mouse0.91714272
90FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91522336
91* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90393152
92SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.89952622
93* SPI1_23547873_ChIP-Seq_NB4_Human0.89922278
94IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.87322996
95PKCTHETA_26484144_Chip-Seq_BREAST_Human0.87261811
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.87183131
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86498876
98JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.85552133
99STAT3_1855785_ChIP-Seq_MESCs_Mouse0.85523736
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84058194
101EWS_26573619_Chip-Seq_HEK293_Human0.83762556
102CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.82866752
103NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.82791208
104* KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.82568055
105MYC_18940864_ChIP-ChIP_HL60_Human0.81508402
106POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81116995
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.80848277
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80691860
109ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80250732
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.78549129
111NOTCH1_21737748_ChIP-Seq_TLL_Human0.78493006
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.77168545
113* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.74029452
114* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.73870886
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.73836700
116GATA1_22025678_ChIP-Seq_K562_Human0.65241902
117TCF3_18692474_ChIP-Seq_MEFs_Mouse0.64277526

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.99748468
2MP0008057_abnormal_DNA_replication3.61219001
3MP0003111_abnormal_nucleus_morphology3.56629154
4MP0003693_abnormal_embryo_hatching3.54138454
5* MP0003077_abnormal_cell_cycle3.13793838
6MP0004957_abnormal_blastocyst_morpholog3.04029066
7MP0010352_gastrointestinal_tract_polyps2.75932220
8MP0003123_paternal_imprinting2.56650137
9MP0008007_abnormal_cellular_replicative2.53207506
10MP0002396_abnormal_hematopoietic_system2.49639462
11MP0009697_abnormal_copulation2.15477209
12MP0006054_spinal_hemorrhage2.10550796
13MP0010307_abnormal_tumor_latency2.09880168
14MP0008058_abnormal_DNA_repair2.07893008
15MP0003121_genomic_imprinting2.01096807
16MP0004808_abnormal_hematopoietic_stem2.00693040
17MP0000350_abnormal_cell_proliferation1.97999542
18MP0005076_abnormal_cell_differentiation1.94531828
19MP0003705_abnormal_hypodermis_morpholog1.93393265
20MP0001730_embryonic_growth_arrest1.92321090
21MP0008932_abnormal_embryonic_tissue1.85774539
22MP0000537_abnormal_urethra_morphology1.78478312
23MP0010030_abnormal_orbit_morphology1.73858557
24MP0009053_abnormal_anal_canal1.71607567
25MP0005380_embryogenesis_phenotype1.63018025
26MP0001672_abnormal_embryogenesis/_devel1.63018025
27MP0004197_abnormal_fetal_growth/weight/1.61867234
28MP0003567_abnormal_fetal_cardiomyocyte1.60999517
29MP0001697_abnormal_embryo_size1.59365375
30MP0009278_abnormal_bone_marrow1.57663093
31MP0003984_embryonic_growth_retardation1.51661074
32MP0002088_abnormal_embryonic_growth/wei1.50637593
33MP0002085_abnormal_embryonic_tissue1.49681345
34MP0002084_abnormal_developmental_patter1.48784258
35MP0002086_abnormal_extraembryonic_tissu1.47695694
36* MP0000490_abnormal_crypts_of1.46095931
37MP0002080_prenatal_lethality1.38838744
38MP0004185_abnormal_adipocyte_glucose1.31951131
39MP0000703_abnormal_thymus_morphology1.29886802
40MP0005397_hematopoietic_system_phenotyp1.25025103
41MP0001545_abnormal_hematopoietic_system1.25025103
42MP0002877_abnormal_melanocyte_morpholog1.24657616
43MP0003763_abnormal_thymus_physiology1.24517767
44MP0002019_abnormal_tumor_incidence1.24285542
45MP0001293_anophthalmia1.23173408
46MP0003718_maternal_effect1.22914724
47MP0000313_abnormal_cell_death1.22432419
48MP0006292_abnormal_olfactory_placode1.22209325
49MP0000733_abnormal_muscle_development1.19279440
50MP0001346_abnormal_lacrimal_gland1.19081522
51MP0008877_abnormal_DNA_methylation1.17604466
52MP0003937_abnormal_limbs/digits/tail_de1.15217633
53MP0003890_abnormal_embryonic-extraembry1.12853153
54MP0003786_premature_aging1.08483148
55MP0000569_abnormal_digit_pigmentation1.07539029
56* MP0002398_abnormal_bone_marrow1.06669572
57MP0002166_altered_tumor_susceptibility1.06505946
58MP0003221_abnormal_cardiomyocyte_apopto1.04223107
59MP0003941_abnormal_skin_development1.02981177
60MP0001849_ear_inflammation1.01244688
61MP0003115_abnormal_respiratory_system1.00654924
62MP0009703_decreased_birth_body1.00606631
63MP0003300_gastrointestinal_ulcer1.00047454
64MP0000428_abnormal_craniofacial_morphol0.99131002
65MP0002092_abnormal_eye_morphology0.98964971
66MP0002009_preneoplasia0.96860563
67MP0009672_abnormal_birth_weight0.96852059
68MP0010234_abnormal_vibrissa_follicle0.96486841
69MP0001915_intracranial_hemorrhage0.95457640
70MP0003935_abnormal_craniofacial_develop0.94759585
71MP0002722_abnormal_immune_system0.93990971
72MP0003861_abnormal_nervous_system0.93593734
73MP0002938_white_spotting0.90176110
74MP0009333_abnormal_splenocyte_physiolog0.88733908
75MP0001929_abnormal_gametogenesis0.88645224
76MP0002925_abnormal_cardiovascular_devel0.87713817
77MP0003943_abnormal_hepatobiliary_system0.87291673
78MP0003566_abnormal_cell_adhesion0.87187290
79MP0002006_tumorigenesis0.87022613
80MP0003385_abnormal_body_wall0.86181775
81MP0002111_abnormal_tail_morphology0.85863447
82MP0003787_abnormal_imprinting0.85840956
83MP0002233_abnormal_nose_morphology0.84989854
84MP0003122_maternal_imprinting0.84958548
85MP0001145_abnormal_male_reproductive0.84940061
86MP0000689_abnormal_spleen_morphology0.83114971
87MP0000566_synostosis0.82193323
88MP0000432_abnormal_head_morphology0.80930292
89MP0002932_abnormal_joint_morphology0.80437213
90MP0003315_abnormal_perineum_morphology0.80109791
91MP0002697_abnormal_eye_size0.79738524
92MP0003942_abnormal_urinary_system0.77528281
93MP0001286_abnormal_eye_development0.77289427
94MP0005621_abnormal_cell_physiology0.75812098
95MP0005023_abnormal_wound_healing0.75735256
96MP0002095_abnormal_skin_pigmentation0.74789218
97MP0004264_abnormal_extraembryonic_tissu0.74403629
98* MP0002429_abnormal_blood_cell0.74188645
99MP0000858_altered_metastatic_potential0.73459538
100MP0000383_abnormal_hair_follicle0.73078121
101MP0000685_abnormal_immune_system0.72919384
102MP0003119_abnormal_digestive_system0.72658438
103MP0005384_cellular_phenotype0.72331608
104MP0000653_abnormal_sex_gland0.71414802
105* MP0000477_abnormal_intestine_morphology0.71390555
106MP0000358_abnormal_cell_content/0.69159409
107MP0003755_abnormal_palate_morphology0.69064353
108MP0006035_abnormal_mitochondrial_morpho0.68872082
109MP0000049_abnormal_middle_ear0.68430075
110MP0005174_abnormal_tail_pigmentation0.67719894
111MP0010678_abnormal_skin_adnexa0.66475084
112MP0001119_abnormal_female_reproductive0.66347765
113MP0000716_abnormal_immune_system0.66085517
114MP0002282_abnormal_trachea_morphology0.65552021
115MP0005501_abnormal_skin_physiology0.65430009
116MP0005187_abnormal_penis_morphology0.64886704
117MP0002234_abnormal_pharynx_morphology0.64684656
118MP0005391_vision/eye_phenotype0.64639602
119MP0002081_perinatal_lethality0.63703428
120MP0000266_abnormal_heart_morphology0.63443726
121MP0002210_abnormal_sex_determination0.63415198
122MP0001661_extended_life_span0.63182096
123MP0003699_abnormal_female_reproductive0.62465353
124MP0001873_stomach_inflammation0.62000410
125MP0002075_abnormal_coat/hair_pigmentati0.61751599
126MP0006072_abnormal_retinal_apoptosis0.61189191
127MP0002751_abnormal_autonomic_nervous0.60804632
128MP0002114_abnormal_axial_skeleton0.56506676
129MP0001727_abnormal_embryo_implantation0.56424812
130MP0001529_abnormal_vocalization0.55355396
131MP0005499_abnormal_olfactory_system0.50112477
132MP0005394_taste/olfaction_phenotype0.50112477
133MP0005623_abnormal_meninges_morphology0.49998149

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.79313020
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.79313020
3Volvulus (HP:0002580)3.78604962
4Cortical dysplasia (HP:0002539)3.72156123
5Increased nuchal translucency (HP:0010880)3.31514158
6Colon cancer (HP:0003003)3.14812607
7Chromsome breakage (HP:0040012)3.07416335
8Selective tooth agenesis (HP:0001592)3.06559273
9Abnormality of the 4th metacarpal (HP:0010012)2.80834836
10Abnormality of chromosome stability (HP:0003220)2.77720610
11Chromosomal breakage induced by crosslinking agents (HP:0003221)2.73625699
12Reticulocytopenia (HP:0001896)2.72183807
13Renal duplication (HP:0000075)2.70078687
14Absent radius (HP:0003974)2.62666497
15Medulloblastoma (HP:0002885)2.61133174
16Proximal placement of thumb (HP:0009623)2.59777070
17Deviation of the thumb (HP:0009603)2.58236524
18Abnormality of the fingertips (HP:0001211)2.56250228
19Clubbing of toes (HP:0100760)2.51942660
20Ependymoma (HP:0002888)2.47907470
21High anterior hairline (HP:0009890)2.45941130
22Absent forearm bone (HP:0003953)2.44834012
23Aplasia involving forearm bones (HP:0009822)2.44834012
24Hyperacusis (HP:0010780)2.43998643
25Ectopic kidney (HP:0000086)2.41093622
26Atresia of the external auditory canal (HP:0000413)2.33396507
27Embryonal neoplasm (HP:0002898)2.32928600
28Birth length less than 3rd percentile (HP:0003561)2.29597449
2911 pairs of ribs (HP:0000878)2.28938591
30Patellar aplasia (HP:0006443)2.28593569
31Myelodysplasia (HP:0002863)2.28108806
32Triphalangeal thumb (HP:0001199)2.27816434
33Rhabdomyosarcoma (HP:0002859)2.26740437
34Arteriovenous malformation (HP:0100026)2.24524941
35Subacute progressive viral hepatitis (HP:0006572)2.23329721
36Meckel diverticulum (HP:0002245)2.22867639
37High pitched voice (HP:0001620)2.21734929
38Abnormal lung lobation (HP:0002101)2.18369119
39Syringomyelia (HP:0003396)2.18264092
40Spinal cord lesions (HP:0100561)2.18264092
41Aplasia/Hypoplasia of the patella (HP:0006498)2.16793891
42Choanal atresia (HP:0000453)2.15807300
43Basal cell carcinoma (HP:0002671)2.13220383
44Abnormal number of incisors (HP:0011064)2.12505359
45Broad palm (HP:0001169)2.11875979
46Small intestinal stenosis (HP:0012848)2.11315944
47Duodenal stenosis (HP:0100867)2.11315944
48Abnormality of the ileum (HP:0001549)2.10979493
49Nephroblastoma (Wilms tumor) (HP:0002667)2.08998606
50Long eyelashes (HP:0000527)2.07586813
51Cutis marmorata (HP:0000965)2.07091630
52Renovascular hypertension (HP:0100817)2.05795621
53Malignant gastrointestinal tract tumors (HP:0006749)2.05478708
54Gastrointestinal carcinoma (HP:0002672)2.05478708
55Aplasia/Hypoplasia of the uvula (HP:0010293)2.03071026
56Missing ribs (HP:0000921)2.02036373
57Abnormality of the preputium (HP:0100587)2.01835499
58Asymmetry of the thorax (HP:0001555)2.01318282
59Horseshoe kidney (HP:0000085)1.99886126
60Duplication of thumb phalanx (HP:0009942)1.99803742
61Short thumb (HP:0009778)1.99551586
62Rectal prolapse (HP:0002035)1.98517757
63Deep philtrum (HP:0002002)1.97637655
64Embryonal renal neoplasm (HP:0011794)1.96647472
65Prominent nose (HP:0000448)1.96049311
66Aplasia/Hypoplasia of the sacrum (HP:0008517)1.95367995
67Cutaneous melanoma (HP:0012056)1.93814619
68Leiomyosarcoma (HP:0100243)1.92538739
69Uterine leiomyosarcoma (HP:0002891)1.92538739
70Abnormality of the carotid arteries (HP:0005344)1.92411865
71Abnormal umbilical cord blood vessels (HP:0011403)1.92188206
72Single umbilical artery (HP:0001195)1.92188206
73Abnormality of the fetal cardiovascular system (HP:0010948)1.92188206
74Abnormality of the calcaneus (HP:0008364)1.92186028
75Short middle phalanx of the 5th finger (HP:0004220)1.90783973
76Cafe-au-lait spot (HP:0000957)1.90770941
77Astrocytoma (HP:0009592)1.90236221
78Abnormality of the astrocytes (HP:0100707)1.90236221
79Facial hemangioma (HP:0000329)1.89488514
80Impulsivity (HP:0100710)1.89415426
81Duplicated collecting system (HP:0000081)1.89304717
82Neoplasm of the pancreas (HP:0002894)1.87999228
83Abnormality of the labia minora (HP:0012880)1.87852048
84Multiple enchondromatosis (HP:0005701)1.87583808
85Breast hypoplasia (HP:0003187)1.87053885
86Abnormality of chromosome segregation (HP:0002916)1.86770726
87Increased density of long bones (HP:0006392)1.84708629
88Microvesicular hepatic steatosis (HP:0001414)1.83573527
89Neoplasm of striated muscle (HP:0009728)1.83449241
90Thrombocytosis (HP:0001894)1.83297402
91Biliary tract neoplasm (HP:0100574)1.82867937
92Progressive external ophthalmoplegia (HP:0000590)1.82470582
93Abnormality of the duodenum (HP:0002246)1.82402967
94Overlapping toe (HP:0001845)1.82235920
95Ovarian neoplasm (HP:0100615)1.80255123
96Acute myeloid leukemia (HP:0004808)1.78567580
97Transitional cell carcinoma of the bladder (HP:0006740)1.78238085
98Long clavicles (HP:0000890)1.78053034
99Truncal obesity (HP:0001956)1.77626311
100Acute lymphatic leukemia (HP:0006721)1.77496648
101Skull defect (HP:0001362)1.77440615
102Skin tags (HP:0010609)1.77033463
103Intestinal polyp (HP:0005266)1.76482555
104Mesomelia (HP:0003027)1.76428110
105Sloping forehead (HP:0000340)1.76299419
106Neoplasm of the colon (HP:0100273)1.75535412
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.75399002
108Short 5th finger (HP:0009237)1.75384935
109Bicuspid aortic valve (HP:0001647)1.74911422
110Intestinal polyposis (HP:0200008)1.74309841
111Elfin facies (HP:0004428)1.72916956
112Obsessive-compulsive behavior (HP:0000722)1.72675945
113Neoplasm of the oral cavity (HP:0100649)1.71458777
114Abnormality of cochlea (HP:0000375)1.70944487
115Glioma (HP:0009733)1.70507510
116Sandal gap (HP:0001852)1.69831387
117Combined immunodeficiency (HP:0005387)1.68826322
118Abnormality of cells of the erythroid lineage (HP:0012130)1.68777044
119Overriding aorta (HP:0002623)1.68035090
120Preauricular skin tag (HP:0000384)1.67237086
121Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.65896216
122Broad thumb (HP:0011304)1.65811044
123Viral hepatitis (HP:0006562)1.63725165
124Uterine neoplasm (HP:0010784)1.63069970
125Bladder neoplasm (HP:0009725)1.62689297
126Bladder carcinoma (HP:0002862)1.62689297
127Tracheoesophageal fistula (HP:0002575)1.62609385
128Abnormal number of erythroid precursors (HP:0012131)1.62255969
129Blepharitis (HP:0000498)1.61786336
130Insidious onset (HP:0003587)1.61757412
131Termporal pattern (HP:0011008)1.61757412
132Agnosia (HP:0010524)1.61583928
133Shallow orbits (HP:0000586)1.61545096
134Bowel diverticulosis (HP:0005222)1.61500794
135Abnormality of DNA repair (HP:0003254)1.59884557
136Bone marrow hypocellularity (HP:0005528)1.59826131
137IgM deficiency (HP:0002850)1.59347592
138Abnormality of the umbilical cord (HP:0010881)1.58916296
139Facial asymmetry (HP:0000324)1.55034951
140Neoplasm of the adrenal cortex (HP:0100641)1.54113414

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.65383964
2NEK23.10545863
3WEE13.05424297
4MAP3K102.89867653
5EEF2K2.74575696
6BUB12.54128730
7CDK122.52020759
8PKN22.38039847
9PBK2.34590930
10PASK2.13455750
11TTK2.13417094
12MKNK12.03213665
13TAF12.01310847
14SRPK11.99857284
15BRSK21.94192086
16STK101.89130097
17ATR1.79896256
18RPS6KB21.77326455
19SMG11.75477759
20AURKB1.72151685
21RPS6KA41.68519202
22CDK41.67414565
23DYRK31.64258038
24PLK11.56430524
25TGFBR11.55874611
26STK41.52983935
27ACVR1B1.49271188
28LATS11.49263477
29MAP3K81.48862287
30CDK61.47652808
31TRIB31.47285598
32MKNK21.44510038
33TLK11.40610788
34STK31.40210528
35CDK71.38870449
36NEK11.37518257
37BRD41.37465603
38VRK21.28640680
39PTK61.28493008
40CHEK21.27454264
41FLT31.27160291
42PAK41.24232431
43CHEK11.23185172
44PLK31.21949172
45MAP4K11.16919633
46SCYL21.16175250
47LRRK21.15491076
48CLK11.14501136
49EIF2AK21.12791683
50PLK41.10076806
51TSSK61.09464686
52ATM1.07341584
53BRSK11.07032621
54MELK1.06226773
55VRK11.05877342
56TTN1.05368200
57PNCK1.02556842
58EIF2AK11.02007228
59PIM10.99144374
60TRIM280.97321797
61ZAK0.89843458
62CDK20.86092464
63CDK80.81394695
64PDGFRA0.80964026
65BRAF0.79124651
66CDK90.75423587
67ALK0.74301658
68NEK90.73827824
69ICK0.73357146
70ERBB30.71774503
71CCNB10.71679572
72BCR0.69444490
73MTOR0.67402710
74JAK30.66987803
75* CDK10.66459637
76MAP2K30.65813540
77CSF1R0.65272067
78BTK0.63286145
79CDK30.61948973
80AURKA0.60959410
81DYRK1B0.60027720
82NUAK10.59739791
83NME20.56859126
84FGFR30.54960524
85GRK60.54865148
86PAK20.51823943
87RPS6KA50.51547326
88FGFR10.51396915
89TESK20.50675672
90RIPK10.49855111
91ERBB40.49719267
92TRPM70.48808594
93CHUK0.48460804
94MST40.46177269
95PRKDC0.44970451
96KSR10.44876558
97ILK0.43703267
98MARK30.42673101
99CDK180.42617807
100LATS20.40583566
101CDK150.40043256
102AKT20.39023374
103MAPK140.38834091
104STK38L0.38410391
105CDK11A0.37992472
106RPS6KC10.37873086
107RPS6KL10.37873086
108RPS6KA60.37354476
109KIT0.37167438
110CSNK2A20.37144306
111AKT10.36983468
112ERBB20.36207153
113CDK140.35546235
114CSNK1E0.35180074
115ZAP700.35171471
116CSNK2A10.35037076
117CSNK1D0.34772074
118YES10.34099475
119PRPF4B0.31616720
120NLK0.31375143
121PDGFRB0.30824375
122EIF2AK30.30786388
123PAK10.30525546
124MAP3K40.29322792
125RAF10.26698299
126BMPR1B0.24303410
127GSK3B0.23052328
128CAMK1G0.19154847
129CSNK1G10.18388899
130RPS6KB10.16447229

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.66453319
2Mismatch repair_Homo sapiens_hsa034303.82321618
3Cell cycle_Homo sapiens_hsa041103.27420046
4Spliceosome_Homo sapiens_hsa030402.98872560
5Base excision repair_Homo sapiens_hsa034102.94781125
6RNA transport_Homo sapiens_hsa030132.61443846
7Homologous recombination_Homo sapiens_hsa034402.60060423
8One carbon pool by folate_Homo sapiens_hsa006702.48569095
9Non-homologous end-joining_Homo sapiens_hsa034502.36792858
10Nucleotide excision repair_Homo sapiens_hsa034202.32635876
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23919621
12Fanconi anemia pathway_Homo sapiens_hsa034602.18835799
13Systemic lupus erythematosus_Homo sapiens_hsa053222.15952512
14mRNA surveillance pathway_Homo sapiens_hsa030152.05352401
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.78338754
16p53 signaling pathway_Homo sapiens_hsa041151.76222608
17Ribosome_Homo sapiens_hsa030101.75151644
18RNA degradation_Homo sapiens_hsa030181.64965688
19Viral carcinogenesis_Homo sapiens_hsa052031.60141364
20MicroRNAs in cancer_Homo sapiens_hsa052061.45363039
21Small cell lung cancer_Homo sapiens_hsa052221.42330761
22Pyrimidine metabolism_Homo sapiens_hsa002401.42142657
23Chronic myeloid leukemia_Homo sapiens_hsa052201.41914518
24Herpes simplex infection_Homo sapiens_hsa051681.32618745
25HTLV-I infection_Homo sapiens_hsa051661.30606600
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.29140807
27Antigen processing and presentation_Homo sapiens_hsa046121.26435326
28Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.23069252
29Biosynthesis of amino acids_Homo sapiens_hsa012301.22417078
30RNA polymerase_Homo sapiens_hsa030201.19153172
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.13937210
32Colorectal cancer_Homo sapiens_hsa052101.11308939
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11111399
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.10180153
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.10176412
36Epstein-Barr virus infection_Homo sapiens_hsa051691.09494238
37Thyroid cancer_Homo sapiens_hsa052161.04003336
38Basal transcription factors_Homo sapiens_hsa030221.03122533
39Basal cell carcinoma_Homo sapiens_hsa052171.02633139
40Selenocompound metabolism_Homo sapiens_hsa004501.00839331
41Primary immunodeficiency_Homo sapiens_hsa053401.00432180
42Alcoholism_Homo sapiens_hsa050340.98003982
43Hepatitis B_Homo sapiens_hsa051610.95636823
44Oocyte meiosis_Homo sapiens_hsa041140.93260962
45Adherens junction_Homo sapiens_hsa045200.93172368
46Lysine degradation_Homo sapiens_hsa003100.90854709
47Non-small cell lung cancer_Homo sapiens_hsa052230.89340647
48Viral myocarditis_Homo sapiens_hsa054160.89212147
49Pancreatic cancer_Homo sapiens_hsa052120.87808334
50Hippo signaling pathway_Homo sapiens_hsa043900.86345225
51Measles_Homo sapiens_hsa051620.84453474
52Notch signaling pathway_Homo sapiens_hsa043300.82887077
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82647294
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82319256
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.82130561
56Prostate cancer_Homo sapiens_hsa052150.81912669
57Apoptosis_Homo sapiens_hsa042100.80565390
58NF-kappa B signaling pathway_Homo sapiens_hsa040640.79809880
59Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.79608088
60TGF-beta signaling pathway_Homo sapiens_hsa043500.79207937
612-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76333175
62Endometrial cancer_Homo sapiens_hsa052130.76070947
63Pyruvate metabolism_Homo sapiens_hsa006200.75795422
64Legionellosis_Homo sapiens_hsa051340.75709022
65Steroid biosynthesis_Homo sapiens_hsa001000.75677895
66Proteoglycans in cancer_Homo sapiens_hsa052050.73410126
67Bladder cancer_Homo sapiens_hsa052190.72201160
68Carbon metabolism_Homo sapiens_hsa012000.72188499
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.70760531
70B cell receptor signaling pathway_Homo sapiens_hsa046620.70485246
71Acute myeloid leukemia_Homo sapiens_hsa052210.69909150
72Pathways in cancer_Homo sapiens_hsa052000.66646853
73mTOR signaling pathway_Homo sapiens_hsa041500.60388641
74Pentose phosphate pathway_Homo sapiens_hsa000300.60261235
75Shigellosis_Homo sapiens_hsa051310.60183145
76Influenza A_Homo sapiens_hsa051640.59284704
77Vitamin B6 metabolism_Homo sapiens_hsa007500.59157507
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59074834
79Toxoplasmosis_Homo sapiens_hsa051450.58408741
80Leishmaniasis_Homo sapiens_hsa051400.58275109
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.57567979
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57545288
83Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56932895
84Hedgehog signaling pathway_Homo sapiens_hsa043400.55212208
85FoxO signaling pathway_Homo sapiens_hsa040680.55096527
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54205229
87Purine metabolism_Homo sapiens_hsa002300.54201804
88Proteasome_Homo sapiens_hsa030500.53047650
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51477834
90N-Glycan biosynthesis_Homo sapiens_hsa005100.51362806
91Focal adhesion_Homo sapiens_hsa045100.51344719
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.50294829
93Protein export_Homo sapiens_hsa030600.49933651
94Hematopoietic cell lineage_Homo sapiens_hsa046400.47808580
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.47271191
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46927292
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46255188
98T cell receptor signaling pathway_Homo sapiens_hsa046600.45940497
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.45620519
100Wnt signaling pathway_Homo sapiens_hsa043100.45258780
101RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.43202501
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43055971
103Platelet activation_Homo sapiens_hsa046110.42282597
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.42261675
105Melanoma_Homo sapiens_hsa052180.40301658
106TNF signaling pathway_Homo sapiens_hsa046680.39343014
107Folate biosynthesis_Homo sapiens_hsa007900.37530271
108Propanoate metabolism_Homo sapiens_hsa006400.36761007
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36566174
110Jak-STAT signaling pathway_Homo sapiens_hsa046300.36552387
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.35147364
112HIF-1 signaling pathway_Homo sapiens_hsa040660.34557209
113Osteoclast differentiation_Homo sapiens_hsa043800.33959529
114Glioma_Homo sapiens_hsa052140.33199327
115Renal cell carcinoma_Homo sapiens_hsa052110.33168757
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31837442
117Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30230619
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29719942
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.29170291
120Prolactin signaling pathway_Homo sapiens_hsa049170.29144375
121Inositol phosphate metabolism_Homo sapiens_hsa005620.22802894
122ErbB signaling pathway_Homo sapiens_hsa040120.22489286
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20200018
124Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.17704036
125Tight junction_Homo sapiens_hsa045300.14730212
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14224512
127AMPK signaling pathway_Homo sapiens_hsa041520.14085977
128Melanogenesis_Homo sapiens_hsa049160.13607982
129Insulin signaling pathway_Homo sapiens_hsa049100.08182352

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