TMOD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the tropomodulin family. The encoded protein is an actin-capping protein that regulates tropomyosin by binding to its N-terminus, inhibiting depolymerization and elongation of the pointed end of actin filaments and thereby influencing the structure of the erythrocyte membrane skeleton. Multiple transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)6.36817531
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.05281287
3cardiac myofibril assembly (GO:0055003)5.99443778
4* muscle filament sliding (GO:0030049)5.96889857
5* actin-myosin filament sliding (GO:0033275)5.96889857
6* myofibril assembly (GO:0030239)5.48984535
7negative regulation of potassium ion transmembrane transport (GO:1901380)5.34261768
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.21264464
9sarcoplasmic reticulum calcium ion transport (GO:0070296)5.15244141
10* actin-mediated cell contraction (GO:0070252)5.08782564
11central nervous system myelination (GO:0022010)5.07340420
12axon ensheathment in central nervous system (GO:0032291)5.07340420
13regulation of relaxation of muscle (GO:1901077)5.07215744
14regulation of actin filament-based movement (GO:1903115)4.96294725
15regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.94310556
16negative regulation of protein localization to cell surface (GO:2000009)4.92769983
17cardiac muscle contraction (GO:0060048)4.86817733
18regulation of cell communication by electrical coupling (GO:0010649)4.84076682
19positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.80544600
20regulation of skeletal muscle contraction (GO:0014819)4.68793840
21cardiac muscle tissue morphogenesis (GO:0055008)4.54734395
22regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.52782544
23regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.43188874
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.39363789
25regulation of sarcomere organization (GO:0060297)4.31750448
26striated muscle contraction (GO:0006941)4.28726302
27heart process (GO:0003015)4.24666395
28heart contraction (GO:0060047)4.24666395
29ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.23399030
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.21286291
31regulation of striated muscle contraction (GO:0006942)4.20110427
32* actomyosin structure organization (GO:0031032)4.20023808
33creatine metabolic process (GO:0006600)4.13661497
34cardiac muscle cell development (GO:0055013)4.12320391
35adult heart development (GO:0007512)4.12245596
36muscle tissue morphogenesis (GO:0060415)4.10781284
37response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.07105540
38regulation of membrane repolarization (GO:0060306)4.04744069
39plasma membrane repair (GO:0001778)3.94117152
40cardiac muscle hypertrophy (GO:0003300)3.91102821
41cardiac cell development (GO:0055006)3.90348682
42heart trabecula formation (GO:0060347)3.78637094
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.78202690
44relaxation of cardiac muscle (GO:0055119)3.77895325
45ventricular cardiac muscle cell action potential (GO:0086005)3.76124417
46striated muscle hypertrophy (GO:0014897)3.74955960
47respiratory electron transport chain (GO:0022904)3.70829669
48* actin filament-based movement (GO:0030048)3.69145371
49membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.68130855
50regulation of cardiac muscle cell contraction (GO:0086004)3.62983859
51electron transport chain (GO:0022900)3.61160542
52ATP synthesis coupled proton transport (GO:0015986)3.58763247
53energy coupled proton transport, down electrochemical gradient (GO:0015985)3.58763247
54relaxation of muscle (GO:0090075)3.58544479
55oxygen transport (GO:0015671)3.54877177
56striated muscle adaptation (GO:0014888)3.52863391
57NADH metabolic process (GO:0006734)3.51918852
58cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.51344805
59gas transport (GO:0015669)3.49766635
60response to inactivity (GO:0014854)3.49721392
61regulation of cardiac muscle contraction (GO:0055117)3.49632841
62cell communication involved in cardiac conduction (GO:0086065)3.49166092
63negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.47413682
64regulation of cardioblast differentiation (GO:0051890)3.45516107
65regulation of ATP catabolic process (GO:1903289)3.40139184
66regulation of ATPase activity (GO:0043462)3.40139184
67skeletal muscle contraction (GO:0003009)3.38692715
68tricarboxylic acid cycle (GO:0006099)3.36628594
69regulation of calcium ion transmembrane transporter activity (GO:1901019)3.36266196
70regulation of calcium ion transmembrane transport (GO:1903169)3.36266196
71glucan biosynthetic process (GO:0009250)3.35911936
72glycogen biosynthetic process (GO:0005978)3.35911936
73bundle of His cell to Purkinje myocyte communication (GO:0086069)3.30766760
74carnitine shuttle (GO:0006853)3.30708098
75skeletal muscle adaptation (GO:0043501)3.30436887
76succinate metabolic process (GO:0006105)3.29739852
77regulation of the force of heart contraction (GO:0002026)3.25968498
78muscle hypertrophy (GO:0014896)3.25064838
79glycogen catabolic process (GO:0005980)3.21255448
80regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.18392136
81positive regulation of potassium ion transmembrane transport (GO:1901381)3.17306465
82ensheathment of neurons (GO:0007272)3.15857296
83axon ensheathment (GO:0008366)3.15857296
84positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.15059774
85negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.15020846
86response to muscle activity (GO:0014850)3.14628227
87negative regulation of striated muscle cell apoptotic process (GO:0010664)3.13474789
88myelination (GO:0042552)3.13138950
89negative regulation of cytosolic calcium ion concentration (GO:0051481)3.10571993
90muscle fiber development (GO:0048747)3.09911271
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.09552969
92regulation of heart rate (GO:0002027)3.09444478
93detection of calcium ion (GO:0005513)3.08222968
94cellular response to epinephrine stimulus (GO:0071872)3.05270239
95positive regulation of potassium ion transport (GO:0043268)3.04820899
96cardiac muscle cell action potential involved in contraction (GO:0086002)3.02527481
97regulation of acyl-CoA biosynthetic process (GO:0050812)3.02251514
98response to epinephrine (GO:0071871)3.01569753
99skeletal muscle fiber development (GO:0048741)2.99389552
100cardiac conduction (GO:0061337)2.98907828
101positive regulation of sodium ion transport (GO:0010765)2.98730368
102cardiac muscle cell action potential (GO:0086001)2.98235403
103glucan catabolic process (GO:0009251)2.97671498
104muscle contraction (GO:0006936)2.97495927
105cardiac chamber formation (GO:0003207)2.96181255
106myotube cell development (GO:0014904)2.96061994
107regulation of heart rate by cardiac conduction (GO:0086091)2.94818737
108positive regulation of action potential (GO:0045760)2.94753478
109negative regulation of calcium ion transmembrane transport (GO:1903170)2.91153864
110negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.91153864
111cell communication by electrical coupling (GO:0010644)2.90647367
112regulation of heart contraction (GO:0008016)2.89818992
113negative regulation of potassium ion transport (GO:0043267)2.88904290
114muscle cell fate commitment (GO:0042693)2.86641314
115regulation of muscle contraction (GO:0006937)2.85353259
116potassium ion import (GO:0010107)2.85027756
117fatty acid transmembrane transport (GO:1902001)2.84668066
118cardiac ventricle formation (GO:0003211)2.83462595
119regulation of potassium ion transmembrane transporter activity (GO:1901016)2.83023443
120regulation of muscle system process (GO:0090257)2.82926867
121neuronal action potential propagation (GO:0019227)2.82126859
122striated muscle cell development (GO:0055002)2.79922642
123regulation of cation channel activity (GO:2001257)2.79324665
124regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.78814893
125muscle system process (GO:0003012)2.76467456
126muscle hypertrophy in response to stress (GO:0003299)2.74457565
127cardiac muscle adaptation (GO:0014887)2.74457565
128cardiac muscle hypertrophy in response to stress (GO:0014898)2.74457565
129positive regulation of cation channel activity (GO:2001259)2.73387923

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.49710778
2* EP300_21415370_ChIP-Seq_HL-1_Mouse2.98820866
3GBX2_23144817_ChIP-Seq_PC3_Human2.67256247
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52832166
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.43074878
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.36812202
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.22174380
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.22174380
9* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.20540376
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.18483974
11CDX2_19796622_ChIP-Seq_MESCs_Mouse2.17697999
12CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.16305627
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.11350279
14GATA1_22025678_ChIP-Seq_K562_Human2.10559586
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02604420
16EZH2_27294783_Chip-Seq_ESCs_Mouse1.95716986
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.95141647
18ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.88684693
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.87812865
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.85627149
21SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84227647
22* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.82577218
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.82278714
24TAF15_26573619_Chip-Seq_HEK293_Human1.81297151
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76029431
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.75624025
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72962012
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.71402265
29SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69819174
30DROSHA_22980978_ChIP-Seq_HELA_Human1.61629295
31* TBX20_22328084_ChIP-Seq_HEART_Mouse1.60439654
32* TBX20_22080862_ChIP-Seq_HEART_Mouse1.60439654
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.58175715
34HTT_18923047_ChIP-ChIP_STHdh_Human1.57617660
35VDR_22108803_ChIP-Seq_LS180_Human1.54637006
36PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53363938
37* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.52668375
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.51300374
39AR_21572438_ChIP-Seq_LNCaP_Human1.43748101
40MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.41311044
41OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40491668
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.40304520
43ZFP57_27257070_Chip-Seq_ESCs_Mouse1.40001165
44RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.37234292
45* GATA2_19941826_ChIP-Seq_K562_Human1.36262493
46PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35325663
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.32189042
48* RARB_27405468_Chip-Seq_BRAIN_Mouse1.32151477
49NR3C1_23031785_ChIP-Seq_PC12_Mouse1.29674245
50IGF1R_20145208_ChIP-Seq_DFB_Human1.29058982
51NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26034871
52SMAD4_21799915_ChIP-Seq_A2780_Human1.25899155
53SMAD3_21741376_ChIP-Seq_HESCs_Human1.25794824
54* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24305346
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24140243
56CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23989633
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23826646
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.23666696
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20825385
60PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.20032699
61ER_23166858_ChIP-Seq_MCF-7_Human1.19605992
62* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19025102
63EZH2_27294783_Chip-Seq_NPCs_Mouse1.17846696
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15799083
65* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15120801
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15073821
67* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14700028
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.14179364
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.13130646
70WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13049924
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12248414
72SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08949316
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.08795319
74TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08501224
75AHR_22903824_ChIP-Seq_MCF-7_Human1.08116596
76TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.07712204
77* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06584390
78NFYB_21822215_ChIP-Seq_K562_Human1.06470713
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05865488
80P300_19829295_ChIP-Seq_ESCs_Human1.04108575
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03945119
82NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03593832
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03593832
84CTCF_27219007_Chip-Seq_Bcells_Human1.01499409
85NANOG_18555785_Chip-Seq_ESCs_Mouse1.00066444
86REST_21632747_ChIP-Seq_MESCs_Mouse1.00031136
87RNF2_27304074_Chip-Seq_NSC_Mouse0.98902421
88TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98168715
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.98160882
90P53_22387025_ChIP-Seq_ESCs_Mouse0.98125998
91E2F1_18555785_Chip-Seq_ESCs_Mouse0.97873752
92PHF8_20622853_ChIP-Seq_HELA_Human0.97868015
93LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.97490541
94ARNT_22903824_ChIP-Seq_MCF-7_Human0.97273171
95EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.97142377
96AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96878228
97FLI1_27457419_Chip-Seq_LIVER_Mouse0.96649850
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96087881
99STAT3_23295773_ChIP-Seq_U87_Human0.95971541
100CTBP2_25329375_ChIP-Seq_LNCAP_Human0.95885125
101REST_18959480_ChIP-ChIP_MESCs_Mouse0.95273243
102GATA1_19941826_ChIP-Seq_K562_Human0.94861070
103TCF4_23295773_ChIP-Seq_U87_Human0.94555006
104CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.94480013
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94205441
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94090176
107EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93492189
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.93396231
109* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93044624
110CRX_20693478_ChIP-Seq_RETINA_Mouse0.92253316
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91970170
112TBL1_22424771_ChIP-Seq_293T_Human0.91536814
113OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91040398
114NANOG_19829295_ChIP-Seq_ESCs_Human0.90605888
115SOX2_19829295_ChIP-Seq_ESCs_Human0.90605888
116SMAD4_21741376_ChIP-Seq_HESCs_Human0.90306064
117SOX2_18555785_Chip-Seq_ESCs_Mouse0.90057015
118ESR2_21235772_ChIP-Seq_MCF-7_Human0.89139224
119RING1B_27294783_Chip-Seq_ESCs_Mouse0.88469532
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.88439535
121* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88359627
122PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.88344078
123EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86584423
124PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.85113097
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85040571
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.85015554
127TP53_18474530_ChIP-ChIP_U2OS_Human0.81583570
128* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.80861017
129STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.79396508
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.79033239

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.93812862
2MP0004084_abnormal_cardiac_muscle4.34826621
3MP0000749_muscle_degeneration4.32277964
4MP0000751_myopathy4.18604327
5MP0004036_abnormal_muscle_relaxation3.98069207
6MP0003646_muscle_fatigue3.63772954
7MP0004145_abnormal_muscle_electrophysio3.53474548
8MP0004215_abnormal_myocardial_fiber3.45150971
9MP0005330_cardiomyopathy2.97808997
10* MP0002972_abnormal_cardiac_muscle2.58522903
11MP0005620_abnormal_muscle_contractility2.53070331
12MP0003137_abnormal_impulse_conducting2.51747933
13* MP0004087_abnormal_muscle_fiber2.49705187
14MP0003950_abnormal_plasma_membrane2.43165643
15MP0000747_muscle_weakness2.35527465
16MP0002106_abnormal_muscle_physiology2.32334992
17MP0008775_abnormal_heart_ventricle2.31670088
18MP0004270_analgesia2.15372753
19MP0004147_increased_porphyrin_level2.09075626
20MP0000920_abnormal_myelination1.99416722
21MP0004484_altered_response_of1.99000701
22* MP0004085_abnormal_heartbeat1.96188203
23MP0005369_muscle_phenotype1.94546601
24MP0002269_muscular_atrophy1.93878266
25MP0000759_abnormal_skeletal_muscle1.93022581
26MP0001485_abnormal_pinna_reflex1.92631971
27MP0001544_abnormal_cardiovascular_syste1.87442440
28MP0005385_cardiovascular_system_phenoty1.87442440
29MP0006138_congestive_heart_failure1.80207967
30* MP0010630_abnormal_cardiac_muscle1.68198057
31MP0000750_abnormal_muscle_regeneration1.68065402
32MP0004130_abnormal_muscle_cell1.62717308
33MP0002735_abnormal_chemical_nociception1.62138099
34MP0003880_abnormal_central_pattern1.60084768
35MP0002272_abnormal_nervous_system1.51921868
36MP0003828_pulmonary_edema1.47880507
37MP0004043_abnormal_pH_regulation1.45754402
38MP0002822_catalepsy1.44803014
39MP0006036_abnormal_mitochondrial_physio1.44455132
40MP0005171_absent_coat_pigmentation1.40465801
41MP0004859_abnormal_synaptic_plasticity1.37339563
42MP0003221_abnormal_cardiomyocyte_apopto1.36727247
43MP0004510_myositis1.35212902
44MP0002638_abnormal_pupillary_reflex1.29264289
45MP0002734_abnormal_mechanical_nocicepti1.26336396
46MP0001486_abnormal_startle_reflex1.25595547
47MP0001529_abnormal_vocalization1.25299648
48MP0002127_abnormal_cardiovascular_syste1.23179782
49MP0001661_extended_life_span1.19855540
50MP0004233_abnormal_muscle_weight1.18313993
51MP0003879_abnormal_hair_cell1.16771837
52MP0002909_abnormal_adrenal_gland1.15136009
53MP0005266_abnormal_metabolism1.14786702
54MP0002332_abnormal_exercise_endurance1.13445756
55MP0003656_abnormal_erythrocyte_physiolo1.13109323
56MP0003878_abnormal_ear_physiology1.12598317
57MP0005377_hearing/vestibular/ear_phenot1.12598317
58MP0005646_abnormal_pituitary_gland1.07139837
59MP0002078_abnormal_glucose_homeostasis1.06586273
60MP0002064_seizures1.05333428
61MP0009745_abnormal_behavioral_response1.05043306
62MP0001905_abnormal_dopamine_level1.03232051
63MP0008569_lethality_at_weaning1.01746268
64MP0003787_abnormal_imprinting0.98566531
65MP0001968_abnormal_touch/_nociception0.97913360
66MP0009046_muscle_twitch0.96976802
67MP0003635_abnormal_synaptic_transmissio0.96080521
68MP0002971_abnormal_brown_adipose0.95861283
69MP0004142_abnormal_muscle_tone0.95585672
70MP0005423_abnormal_somatic_nervous0.95344472
71MP0001970_abnormal_pain_threshold0.94733751
72MP0002229_neurodegeneration0.93713545
73MP0005451_abnormal_body_composition0.93145368
74MP0004924_abnormal_behavior0.92683635
75MP0005386_behavior/neurological_phenoty0.92683635
76MP0001502_abnormal_circadian_rhythm0.92623548
77MP0001963_abnormal_hearing_physiology0.91837258
78MP0002067_abnormal_sensory_capabilities0.90619523
79MP0005645_abnormal_hypothalamus_physiol0.86368282
80MP0000003_abnormal_adipose_tissue0.86323341
81MP0002736_abnormal_nociception_after0.86006953
82MP0003329_amyloid_beta_deposits0.85977224
83MP0005535_abnormal_body_temperature0.85520429
84MP0004742_abnormal_vestibular_system0.85289638
85MP0001299_abnormal_eye_distance/0.84180913
86MP0005670_abnormal_white_adipose0.82903417
87MP0003634_abnormal_glial_cell0.82708464
88MP0003045_fibrosis0.82302309
89MP0001984_abnormal_olfaction0.82025886
90MP0003136_yellow_coat_color0.81235512
91MP0002693_abnormal_pancreas_physiology0.79604151
92MP0005623_abnormal_meninges_morphology0.79351557
93MP0008260_abnormal_autophagy0.78584679
94MP0002733_abnormal_thermal_nociception0.78532767
95MP0003690_abnormal_glial_cell0.77307341
96MP0002108_abnormal_muscle_morphology0.76688256
97MP0000230_abnormal_systemic_arterial0.75860202
98MP0003011_delayed_dark_adaptation0.75429399
99MP0001944_abnormal_pancreas_morphology0.73665272
100MP0004885_abnormal_endolymph0.73445967
101MP0000026_abnormal_inner_ear0.73409274
102MP0005375_adipose_tissue_phenotype0.70963457
103MP0005332_abnormal_amino_acid0.69763629
104MP0000733_abnormal_muscle_development0.69186795
105MP0005379_endocrine/exocrine_gland_phen0.69178693
106MP0003195_calcinosis0.69158842
107MP0002066_abnormal_motor_capabilities/c0.68911559
108MP0006276_abnormal_autonomic_nervous0.68043733
109MP0003122_maternal_imprinting0.67487551
110MP0001440_abnormal_grooming_behavior0.67298171
111MP0009780_abnormal_chondrocyte_physiolo0.66978297
112MP0002063_abnormal_learning/memory/cond0.66601706
113MP0002882_abnormal_neuron_morphology0.66395242
114MP0003123_paternal_imprinting0.65635453
115MP0000778_abnormal_nervous_system0.65551688
116MP0003633_abnormal_nervous_system0.65214276
117MP0003283_abnormal_digestive_organ0.64963955
118MP0003567_abnormal_fetal_cardiomyocyte0.62863603
119MP0005165_increased_susceptibility_to0.62675552
120MP0002572_abnormal_emotion/affect_behav0.62504638
121* MP0000266_abnormal_heart_morphology0.61812003
122MP0005409_darkened_coat_color0.61425315
123MP0000372_irregular_coat_pigmentation0.61391466
124MP0006035_abnormal_mitochondrial_morpho0.60654872
125MP0000013_abnormal_adipose_tissue0.59674149
126MP0000955_abnormal_spinal_cord0.59469401
127MP0002752_abnormal_somatic_nervous0.59326090
128MP0005636_abnormal_mineral_homeostasis0.57850599
129MP0000762_abnormal_tongue_morphology0.57578833
130MP0005448_abnormal_energy_balance0.54168586
131MP0002163_abnormal_gland_morphology0.53464838
132MP0001756_abnormal_urination0.53261773
133MP0005666_abnormal_adipose_tissue0.53243965

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.42789469
2Calf muscle hypertrophy (HP:0008981)6.15076304
3Muscle hypertrophy of the lower extremities (HP:0008968)6.13970870
4Exercise-induced myalgia (HP:0003738)5.90110028
5Exercise-induced muscle cramps (HP:0003710)5.80640451
6Muscle fiber splitting (HP:0003555)5.35478465
7Hyporeflexia of lower limbs (HP:0002600)5.10428207
8Atrial fibrillation (HP:0005110)4.87980655
9Abnormality of the calf musculature (HP:0001430)4.86000569
10Ventricular tachycardia (HP:0004756)4.61402576
11Primary atrial arrhythmia (HP:0001692)4.50452616
12Subaortic stenosis (HP:0001682)4.39841622
13Abnormality of the left ventricular outflow tract (HP:0011103)4.39841622
14Supraventricular tachycardia (HP:0004755)4.30863567
15EMG: myopathic abnormalities (HP:0003458)4.21430530
16Supraventricular arrhythmia (HP:0005115)4.19090808
17Prolonged QT interval (HP:0001657)4.01556522
18Syncope (HP:0001279)3.98002830
19Lipoatrophy (HP:0100578)3.91364445
20Myopathic facies (HP:0002058)3.84336454
21Myoglobinuria (HP:0002913)3.79141909
22Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.64998850
23Muscle fiber inclusion bodies (HP:0100299)3.62707795
24Dilated cardiomyopathy (HP:0001644)3.58390722
25Nemaline bodies (HP:0003798)3.34830591
26Myotonia (HP:0002486)3.31311236
27Pheochromocytoma (HP:0002666)3.30327425
28Difficulty running (HP:0009046)3.22641317
29Acute necrotizing encephalopathy (HP:0006965)3.21893490
30Bundle branch block (HP:0011710)3.21006874
31Ventricular arrhythmia (HP:0004308)3.16816537
32Palpitations (HP:0001962)3.16654060
33Ulnar deviation of the wrist (HP:0003049)3.12045721
34Abnormal mitochondria in muscle tissue (HP:0008316)3.02792994
35Abnormality of the foot musculature (HP:0001436)2.96449984
36Neuroendocrine neoplasm (HP:0100634)2.95976819
37Foot dorsiflexor weakness (HP:0009027)2.94326604
38Neck muscle weakness (HP:0000467)2.91186339
39Ventricular fibrillation (HP:0001663)2.90720277
40Abnormal EKG (HP:0003115)2.89948761
41Right ventricular cardiomyopathy (HP:0011663)2.88309908
42Asymmetric septal hypertrophy (HP:0001670)2.87854339
43Muscle stiffness (HP:0003552)2.84687600
44Type 1 muscle fiber predominance (HP:0003803)2.79833684
45Frequent falls (HP:0002359)2.65437400
46Progressive macrocephaly (HP:0004481)2.65302738
47Hyperinsulinemic hypoglycemia (HP:0000825)2.65109866
48Absent phalangeal crease (HP:0006109)2.64284980
49Left ventricular hypertrophy (HP:0001712)2.63293086
50Mitochondrial inheritance (HP:0001427)2.63199514
51Heart block (HP:0012722)2.60564831
52Rhabdomyolysis (HP:0003201)2.60369751
53Acute encephalopathy (HP:0006846)2.58999336
54Fetal akinesia sequence (HP:0001989)2.56795114
55Calcaneovalgus deformity (HP:0001848)2.52716313
56Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50244752
57Degeneration of the lateral corticospinal tracts (HP:0002314)2.50244752
58Hyperglycemia (HP:0003074)2.48687638
59Hepatic necrosis (HP:0002605)2.47819990
60Myokymia (HP:0002411)2.45648429
61Hepatocellular necrosis (HP:0001404)2.43143894
62Abnormal atrioventricular conduction (HP:0005150)2.42731120
63Gowers sign (HP:0003391)2.42657566
64Hypoglycemic coma (HP:0001325)2.40498603
65Diaphragmatic weakness (HP:0009113)2.39134819
66Abnormality of the heme biosynthetic pathway (HP:0010472)2.36667271
67Insulin-resistant diabetes mellitus (HP:0000831)2.29316005
68Ketoacidosis (HP:0001993)2.29056382
69Increased CSF lactate (HP:0002490)2.27919316
70Distal lower limb muscle weakness (HP:0009053)2.25089581
71Hypoplastic ischia (HP:0003175)2.21567956
72Deformed tarsal bones (HP:0008119)2.20962631
73Centrally nucleated skeletal muscle fibers (HP:0003687)2.20398630
74Areflexia of lower limbs (HP:0002522)2.20100544
75Increased connective tissue (HP:0009025)2.17516276
76Hyperkalemia (HP:0002153)2.17132254
77Atrioventricular block (HP:0001678)2.16807229
78Increased serum pyruvate (HP:0003542)2.13765615
79Abnormality of glycolysis (HP:0004366)2.13765615
80Steppage gait (HP:0003376)2.13234034
81Distal arthrogryposis (HP:0005684)2.12009424
82Malignant hyperthermia (HP:0002047)2.10866187
83Leukodystrophy (HP:0002415)2.10535432
84Abnormal finger flexion creases (HP:0006143)2.10479812
85Increased variability in muscle fiber diameter (HP:0003557)2.10169213
86Late onset (HP:0003584)2.10098076
87Hypoglycemic seizures (HP:0002173)2.09524307
88Palmoplantar keratoderma (HP:0000982)2.06146937
89Exercise intolerance (HP:0003546)2.04298283
90Abnormality of the ischium (HP:0003174)2.04196637
91Round ear (HP:0100830)2.01148582
92Respiratory failure (HP:0002878)1.98157815
93Double outlet right ventricle (HP:0001719)1.96343242
94Congenital malformation of the right heart (HP:0011723)1.96343242
95Hypoplastic left heart (HP:0004383)1.94830706
96Scapular winging (HP:0003691)1.94731856
97Mildly elevated creatine phosphokinase (HP:0008180)1.94144536
98Proximal amyotrophy (HP:0007126)1.93936500
99Abnormality of skeletal muscle fiber size (HP:0012084)1.93777784
100Ragged-red muscle fibers (HP:0003200)1.90738140
101Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.89751630
102Bradycardia (HP:0001662)1.86286702
103Cerebral hemorrhage (HP:0001342)1.86005233
104Focal motor seizures (HP:0011153)1.85643540
105Cholelithiasis (HP:0001081)1.85398428
106Hip contracture (HP:0003273)1.84442065
107Onion bulb formation (HP:0003383)1.84267609
108Hyperthyroidism (HP:0000836)1.84230336
109Poikilocytosis (HP:0004447)1.83977965
110Difficulty climbing stairs (HP:0003551)1.83229817
111Rimmed vacuoles (HP:0003805)1.82912828
112Muscular dystrophy (HP:0003560)1.81687171
113Weak cry (HP:0001612)1.80140792
114Abnormal gallbladder morphology (HP:0012437)1.79771486
115Large for gestational age (HP:0001520)1.78311208
116Cerebral edema (HP:0002181)1.76394084
117Abnormal auditory evoked potentials (HP:0006958)1.74050848
118Bulbar palsy (HP:0001283)1.73219421
119Hypoplastic heart (HP:0001961)1.72941727
120EMG: neuropathic changes (HP:0003445)1.72811534
121Peripheral hypomyelination (HP:0007182)1.72622735
122Increased intramyocellular lipid droplets (HP:0012240)1.71887173
123Distal lower limb amyotrophy (HP:0008944)1.71770835
124Dysmetric saccades (HP:0000641)1.71641926
125Generalized muscle weakness (HP:0003324)1.69981172
126Lactic acidosis (HP:0003128)1.69966254
127Abnormality of the corticospinal tract (HP:0002492)1.69678157
128Sensory axonal neuropathy (HP:0003390)1.68903357
129Limb-girdle muscle atrophy (HP:0003797)1.67233154
130Progressive muscle weakness (HP:0003323)1.66574700
131Paralysis (HP:0003470)1.57786680
132Febrile seizures (HP:0002373)1.56343189
133Increased muscle lipid content (HP:0009058)1.55161082

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.04968328
2STK394.05804722
3PHKG13.73791389
4PHKG23.73791389
5TTN3.01528919
6MYLK2.63082424
7MUSK2.32191048
8WNK42.31625015
9LMTK22.29182739
10OXSR12.19890514
11FRK2.13631414
12PKN12.13477369
13DMPK2.08898423
14PINK12.03574888
15LIMK11.99932037
16PIK3CA1.96354457
17PRPF4B1.88980094
18WNK11.87613583
19EPHB11.78164950
20STK241.76512395
21CAMK2D1.73864736
22PDK31.70174749
23PDK41.70174749
24DAPK21.68313540
25MARK11.67634460
26GRK71.63826166
27BCR1.62647303
28CASK1.51204313
29NTRK11.38428600
30INSRR1.32397058
31PAK31.28053102
32ZAK1.25909061
33UHMK11.23173812
34TIE11.21690852
35ROCK21.18604438
36NME11.18590096
37PDK21.17701967
38CAMK2B1.14066561
39CAMK2A1.13223230
40MET1.11264738
41SGK2231.10683235
42SGK4941.10683235
43MAPKAPK31.09872744
44PRKD11.09384270
45CAMK2G1.06498159
46CDC42BPA1.03108165
47SGK31.01522417
48MAP3K91.01060732
49CDK190.98071309
50MAP2K40.95325085
51PRKCE0.91989765
52ILK0.91300258
53MAP3K20.91288229
54MAP2K30.88540442
55DAPK30.86524356
56EPHA40.85554392
57PTK2B0.82604263
58EIF2AK10.81574404
59TAOK10.81161620
60DDR20.79965115
61PAK60.79043473
62NEK60.78612705
63FGFR30.78310724
64ROCK10.78053600
65BCKDK0.77705388
66MAP2K60.74611416
67MAPK120.74343058
68MAPKAPK50.73694317
69PRKD30.71560765
70MAP2K10.71356910
71PDPK10.70715277
72MAP3K70.65624931
73PRKACB0.62295381
74NTRK30.61161467
75CDK50.60544109
76STK40.59760741
77ERBB30.58990504
78NLK0.58687984
79PRKG10.57767736
80PRKACA0.56000473
81STK38L0.55800621
82CCNB10.55484736
83AKT20.55366282
84PRKAA10.52471584
85PBK0.52048504
86KSR20.51015189
87ARAF0.50966295
88KSR10.50795929
89GRK50.50669929
90AKT30.50400664
91PRKCH0.49568178
92HIPK20.49564775
93CSNK1G30.49018478
94CSNK1A1L0.48702364
95RPS6KA30.48473246
96MAPK40.48398387
97MAP3K50.48323185
98EEF2K0.48198401
99PRKCQ0.48012178
100MAPK70.45666882
101NEK10.45501099
102PRKAA20.45369974
103CAMK10.44790607
104PDK10.44261471
105MARK30.42636999
106RET0.42518887
107PLK20.41724983
108MAPK100.41402578
109SGK10.40957896
110MOS0.39367598
111RIPK10.38593153
112MAPK130.37630636
113RIPK40.36644284
114NTRK20.35887789
115MAP3K40.35371558
116CSNK1G20.35224158
117MAP3K60.35023910
118BMPR20.34973673
119CDK140.34179582
120FGFR20.33892435
121RAF10.33377695
122DYRK1A0.33279120
123MAPK110.33236751
124TNIK0.32526202
125MAP2K70.32433346
126PIK3CG0.31888454
127EPHA30.30812472
128MARK20.30130914
129CAMK40.28421997
130MAP3K130.27273939
131ICK0.26751281
132SGK20.26428574
133MAPK150.26028922
134CSNK1G10.25546076
135MAP3K10.25518724
136PRKACG0.25508160
137STK110.25115032

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.47898002
2Oxidative phosphorylation_Homo sapiens_hsa001903.93885015
3Parkinsons disease_Homo sapiens_hsa050123.70328522
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.43083013
5Dilated cardiomyopathy_Homo sapiens_hsa054143.31705580
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.26033492
7Alzheimers disease_Homo sapiens_hsa050102.91981033
8Fatty acid elongation_Homo sapiens_hsa000622.39903203
9Maturity onset diabetes of the young_Homo sapiens_hsa049502.28913364
10Huntingtons disease_Homo sapiens_hsa050162.20908645
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.19588442
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.14398620
13Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.08063846
14Propanoate metabolism_Homo sapiens_hsa006401.80944065
15Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.65582505
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59466361
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54034827
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46554082
19Calcium signaling pathway_Homo sapiens_hsa040201.26393228
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24120021
21Circadian entrainment_Homo sapiens_hsa047131.23780336
22Vascular smooth muscle contraction_Homo sapiens_hsa042701.20825000
23Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20693524
24Tight junction_Homo sapiens_hsa045301.19569005
25Olfactory transduction_Homo sapiens_hsa047401.16705401
26Insulin secretion_Homo sapiens_hsa049111.15554886
27Oxytocin signaling pathway_Homo sapiens_hsa049211.11623169
28Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10319996
29AMPK signaling pathway_Homo sapiens_hsa041521.06460213
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.06110933
31Serotonergic synapse_Homo sapiens_hsa047261.04792033
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03770952
33Taste transduction_Homo sapiens_hsa047421.03463959
34Gastric acid secretion_Homo sapiens_hsa049711.03231722
35Morphine addiction_Homo sapiens_hsa050321.01980283
36Fatty acid metabolism_Homo sapiens_hsa012121.01277895
37Carbon metabolism_Homo sapiens_hsa012000.99832624
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.99532136
39Pyruvate metabolism_Homo sapiens_hsa006200.98856884
40Collecting duct acid secretion_Homo sapiens_hsa049660.98602553
41Arginine biosynthesis_Homo sapiens_hsa002200.98251833
42Fatty acid degradation_Homo sapiens_hsa000710.98186671
43Ether lipid metabolism_Homo sapiens_hsa005650.98096923
44GABAergic synapse_Homo sapiens_hsa047270.97164821
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96886091
46Glutamatergic synapse_Homo sapiens_hsa047240.95675148
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.94601158
48Renin secretion_Homo sapiens_hsa049240.94362283
49Cholinergic synapse_Homo sapiens_hsa047250.90043872
50Sulfur metabolism_Homo sapiens_hsa009200.86979909
51Nitrogen metabolism_Homo sapiens_hsa009100.84506047
52Axon guidance_Homo sapiens_hsa043600.84337853
53Amphetamine addiction_Homo sapiens_hsa050310.80874076
54Salivary secretion_Homo sapiens_hsa049700.80802311
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79660460
56Dopaminergic synapse_Homo sapiens_hsa047280.78982713
57Protein export_Homo sapiens_hsa030600.76061541
58Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.75246913
59Long-term potentiation_Homo sapiens_hsa047200.75065092
60cAMP signaling pathway_Homo sapiens_hsa040240.74101359
61Arginine and proline metabolism_Homo sapiens_hsa003300.73731103
62Butanoate metabolism_Homo sapiens_hsa006500.71530791
63Bile secretion_Homo sapiens_hsa049760.71121250
64Phototransduction_Homo sapiens_hsa047440.68347371
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.67299514
66Vibrio cholerae infection_Homo sapiens_hsa051100.66819102
67Long-term depression_Homo sapiens_hsa047300.66337714
68Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65654124
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.64818757
70beta-Alanine metabolism_Homo sapiens_hsa004100.63295157
71Synaptic vesicle cycle_Homo sapiens_hsa047210.63256352
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.62874438
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62630649
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62171315
75Pancreatic secretion_Homo sapiens_hsa049720.62152488
76Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61981374
77mTOR signaling pathway_Homo sapiens_hsa041500.61344083
78Cocaine addiction_Homo sapiens_hsa050300.61228213
79Glucagon signaling pathway_Homo sapiens_hsa049220.61001500
80Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.60672174
81Viral myocarditis_Homo sapiens_hsa054160.59329617
82Pentose phosphate pathway_Homo sapiens_hsa000300.58902792
83Dorso-ventral axis formation_Homo sapiens_hsa043200.58807573
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58472363
85Linoleic acid metabolism_Homo sapiens_hsa005910.57936756
86Type II diabetes mellitus_Homo sapiens_hsa049300.57737482
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57681773
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55051891
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54591258
90Gap junction_Homo sapiens_hsa045400.54499158
91FoxO signaling pathway_Homo sapiens_hsa040680.52570005
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52370122
93Regulation of autophagy_Homo sapiens_hsa041400.51764635
94Tryptophan metabolism_Homo sapiens_hsa003800.51622291
95Thyroid hormone synthesis_Homo sapiens_hsa049180.51521485
96Folate biosynthesis_Homo sapiens_hsa007900.50739378
97Starch and sucrose metabolism_Homo sapiens_hsa005000.50595649
98Renal cell carcinoma_Homo sapiens_hsa052110.50507262
99Inositol phosphate metabolism_Homo sapiens_hsa005620.50098827
100Insulin signaling pathway_Homo sapiens_hsa049100.49695303
101Melanogenesis_Homo sapiens_hsa049160.49161067
102Ovarian steroidogenesis_Homo sapiens_hsa049130.48847801
103Steroid biosynthesis_Homo sapiens_hsa001000.47797883
104GnRH signaling pathway_Homo sapiens_hsa049120.47399761
105Oocyte meiosis_Homo sapiens_hsa041140.47006471
106Circadian rhythm_Homo sapiens_hsa047100.46687409
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44899394
108Focal adhesion_Homo sapiens_hsa045100.44672255
109Sphingolipid metabolism_Homo sapiens_hsa006000.43791736
110Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.43331347
111Arachidonic acid metabolism_Homo sapiens_hsa005900.42892457
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.41924449
113MAPK signaling pathway_Homo sapiens_hsa040100.39958052
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39226728
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39151751
116Insulin resistance_Homo sapiens_hsa049310.38749257
117ECM-receptor interaction_Homo sapiens_hsa045120.38064255
118PPAR signaling pathway_Homo sapiens_hsa033200.37275800
119Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37133541
120Nicotine addiction_Homo sapiens_hsa050330.35857337
121Peroxisome_Homo sapiens_hsa041460.35664270
122Tyrosine metabolism_Homo sapiens_hsa003500.35386595
123Ras signaling pathway_Homo sapiens_hsa040140.34967234
124Phenylalanine metabolism_Homo sapiens_hsa003600.34402346
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34393841
126Phospholipase D signaling pathway_Homo sapiens_hsa040720.31260178
127Metabolic pathways_Homo sapiens_hsa011000.30546327

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