TMIGD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane and immunoglobulin domain-containing protein. Alternative splicing results in multiple transcript variants, one of which shares its 5' terminal exon with that of the overlapping adenosine A3 receptor gene (GeneID:140), thus resulting in a fusion product. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.06014083
2multicellular organism reproduction (GO:0032504)8.62015580
3acrosome assembly (GO:0001675)8.51633871
4sperm-egg recognition (GO:0035036)8.48644974
5plasma membrane fusion (GO:0045026)8.48386003
6acrosome reaction (GO:0007340)8.21685508
7Golgi transport vesicle coating (GO:0048200)7.77783139
8COPI coating of Golgi vesicle (GO:0048205)7.77783139
9cell-cell recognition (GO:0009988)7.57180470
10reproduction (GO:0000003)7.45717630
11binding of sperm to zona pellucida (GO:0007339)7.11642860
12adenosine receptor signaling pathway (GO:0001973)6.99640685
13spermatid development (GO:0007286)6.97913656
14cilium or flagellum-dependent cell motility (GO:0001539)6.97068065
15epithelial cilium movement (GO:0003351)6.64327823
16positive regulation of myeloid leukocyte mediated immunity (GO:0002888)6.57580349
17motile cilium assembly (GO:0044458)6.55765101
18axonemal dynein complex assembly (GO:0070286)6.38786894
19regulation of cilium movement (GO:0003352)6.09281990
20positive regulation of mast cell activation involved in immune response (GO:0033008)5.66554026
21positive regulation of mast cell degranulation (GO:0043306)5.66554026
22single fertilization (GO:0007338)5.34518393
23endocrine pancreas development (GO:0031018)5.32431049
24cilium movement (GO:0003341)5.29587724
25sperm capacitation (GO:0048240)5.22566609
26negative regulation of inclusion body assembly (GO:0090084)5.14656731
27macrophage activation involved in immune response (GO:0002281)5.10038289
28epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.07894034
29organic cation transport (GO:0015695)5.02157548
30positive regulation of mast cell activation (GO:0033005)4.94393016
31regulation of myeloid leukocyte mediated immunity (GO:0002886)4.92057085
32calcium ion-dependent exocytosis (GO:0017156)4.83169363
33signal peptide processing (GO:0006465)4.77551767
34COPII vesicle coating (GO:0048208)4.76374638
35regulation of hypersensitivity (GO:0002883)4.70867106
36modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.67582749
37positive regulation by organism of defense response of other organism involved in symbiotic interact4.67582749
38modulation by symbiont of host immune response (GO:0052553)4.67582749
39positive regulation by symbiont of host defense response (GO:0052509)4.67582749
40modulation by symbiont of host defense response (GO:0052031)4.67582749
41modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.67582749
42glycerol ether metabolic process (GO:0006662)4.66433021
43male meiosis (GO:0007140)4.64278242
44retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.59013725
45regulation of microtubule-based movement (GO:0060632)4.58145650
46positive regulation of leukocyte degranulation (GO:0043302)4.56629257
47microglial cell activation (GO:0001774)4.51532559
48protein maturation by protein folding (GO:0022417)4.50393701
49detection of molecule of bacterial origin (GO:0032490)4.49350092
50fertilization (GO:0009566)4.47776697
51regulation of mast cell degranulation (GO:0043304)4.46996830
52G-protein coupled purinergic receptor signaling pathway (GO:0035588)4.45857101
53regulation of type B pancreatic cell apoptotic process (GO:2000674)4.44136906
54synaptonemal complex organization (GO:0070193)4.41217081
55amino sugar catabolic process (GO:0046348)4.41204165
56regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.37665736
57N-acetylneuraminate metabolic process (GO:0006054)4.37621127
58spermatogenesis (GO:0007283)4.34905088
59male gamete generation (GO:0048232)4.32680281
60macroautophagy (GO:0016236)4.32611999
61peptide hormone processing (GO:0016486)4.31860785
62ether metabolic process (GO:0018904)4.29025126
63response to peptidoglycan (GO:0032494)4.28138961
64piRNA metabolic process (GO:0034587)4.26536215
65histamine secretion (GO:0001821)4.24715307
66sequestering of metal ion (GO:0051238)4.22176611
67negative regulation of interleukin-12 production (GO:0032695)4.21922886
68synaptonemal complex assembly (GO:0007130)4.21259214
69neutrophil activation involved in immune response (GO:0002283)4.20283130
70regulation of mast cell activation involved in immune response (GO:0033006)4.18892691
71positive regulation of chemokine secretion (GO:0090197)4.11214837
72regulation of chemokine-mediated signaling pathway (GO:0070099)4.11111984
73lactate metabolic process (GO:0006089)4.05895069
74negative regulation of granulocyte differentiation (GO:0030853)4.03059654
75gamete generation (GO:0007276)3.98610178
76eosinophil chemotaxis (GO:0048245)3.95989464
77regulation of leukocyte degranulation (GO:0043300)3.95600561
78macrophage activation (GO:0042116)3.89534230
79positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.88183810
80nucleoside diphosphate catabolic process (GO:0009134)3.87580861
81germ cell development (GO:0007281)3.83716927
82cellular process involved in reproduction in multicellular organism (GO:0022412)3.82008996
83spermatid nucleus differentiation (GO:0007289)3.79374523
84regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.78618426
85maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.78231419
86insulin secretion (GO:0030073)3.77851786
87regulation of inclusion body assembly (GO:0090083)3.75638752
88adhesion of symbiont to host cell (GO:0044650)3.74460130
89virion attachment to host cell (GO:0019062)3.74460130
90regulation of mast cell activation (GO:0033003)3.72173372
91intra-Golgi vesicle-mediated transport (GO:0006891)3.69036394
92glycosphingolipid catabolic process (GO:0046479)3.68700584
93regulation of mononuclear cell migration (GO:0071675)3.64751269
94positive regulation of antigen processing and presentation (GO:0002579)3.64462323
95regulation of macrophage chemotaxis (GO:0010758)3.63900011
96cellular response to thyroid hormone stimulus (GO:0097067)3.63279584
97glandular epithelial cell differentiation (GO:0002067)3.62179072
98adhesion of symbiont to host (GO:0044406)3.61964588
99immunoglobulin mediated immune response (GO:0016064)3.60791830
100positive regulation of cellular amide metabolic process (GO:0034250)3.59632674
101eosinophil migration (GO:0072677)3.57548001
102intraciliary transport (GO:0042073)3.56416719
103type B pancreatic cell development (GO:0003323)3.51955608
104myeloid cell activation involved in immune response (GO:0002275)3.48082937
105positive regulation of gamma-delta T cell activation (GO:0046645)3.45385342
106cell redox homeostasis (GO:0045454)3.44694217
107microtubule depolymerization (GO:0007019)3.41509722
108regulation of chemokine secretion (GO:0090196)3.41260787
109macrophage differentiation (GO:0030225)3.39582132
110negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.39302711
111vesicle coating (GO:0006901)3.39150353
112sexual reproduction (GO:0019953)3.38674807
113cell recognition (GO:0008037)3.37100951
114ventricular system development (GO:0021591)3.36213370
115positive regulation of insulin secretion (GO:0032024)3.35491034
116ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.35278558
117barbed-end actin filament capping (GO:0051016)3.31847539
118ER overload response (GO:0006983)3.28081609
119activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.27635204
120glycolipid catabolic process (GO:0019377)3.27614975
121left/right pattern formation (GO:0060972)3.26664085
122positive regulation of phagocytosis (GO:0050766)3.25858924
123positive regulation of glycolytic process (GO:0045821)3.24090943
124detection of external biotic stimulus (GO:0098581)3.23960800
125regulation of oxidative phosphorylation (GO:0002082)3.20802357
126multicellular organismal reproductive process (GO:0048609)3.20219648
127regulation of regulated secretory pathway (GO:1903305)3.18591047
128histamine transport (GO:0051608)3.18025287
129pinocytosis (GO:0006907)3.17173593
130purinergic receptor signaling pathway (GO:0035587)3.13802004
131cell-cell junction maintenance (GO:0045217)3.13439621
132glandular epithelial cell development (GO:0002068)3.13181432
133cellular response to ethanol (GO:0071361)3.10892227
134protein localization to Golgi apparatus (GO:0034067)3.10784444
135positive regulation of nuclease activity (GO:0032075)3.09117983
136regulation of acute inflammatory response to antigenic stimulus (GO:0002864)3.08130301
137positive regulation of regulated secretory pathway (GO:1903307)3.06603824
138regulation of interferon-beta biosynthetic process (GO:0045357)3.02298286
139phagocytosis, engulfment (GO:0006911)3.01706591
140response to muramyl dipeptide (GO:0032495)3.01471638
141response to host immune response (GO:0052572)3.00758409
142response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.00758409
143regulation of insulin secretion (GO:0050796)3.00156616
144oligosaccharide catabolic process (GO:0009313)2.97841742
145seminiferous tubule development (GO:0072520)2.97475587
146exocrine pancreas development (GO:0031017)2.96964619
147positive regulation of macrophage cytokine production (GO:0060907)2.96595737
148regulation of antigen processing and presentation (GO:0002577)2.96594401
149detection of calcium ion (GO:0005513)2.94870775
150protein retention in ER lumen (GO:0006621)2.89336554
151detection of biotic stimulus (GO:0009595)2.89105860
152complement activation, alternative pathway (GO:0006957)2.87009773
153L-amino acid import (GO:0043092)2.86781226
154positive regulation of calcium-mediated signaling (GO:0050850)2.86224647
155cellular extravasation (GO:0045123)2.85984497
156ER to Golgi vesicle-mediated transport (GO:0006888)2.84609578
157ceramide catabolic process (GO:0046514)2.84580542
158positive regulation of receptor recycling (GO:0001921)2.84535362
159mannose metabolic process (GO:0006013)2.83790889
160regulation of beta-amyloid formation (GO:1902003)2.83751457
161male meiosis I (GO:0007141)2.83222736
162cellular response to unfolded protein (GO:0034620)2.82891299
163T-helper 1 type immune response (GO:0042088)2.81553008
164negative regulation of erythrocyte differentiation (GO:0045647)2.80550826
165regulation of nuclease activity (GO:0032069)2.80162512
166regulation of apoptotic cell clearance (GO:2000425)2.79944098
167polyol catabolic process (GO:0046174)2.78691206
168regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.77786694
169G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.77317192
170negative regulation of interleukin-17 production (GO:0032700)2.76728718
171Rac protein signal transduction (GO:0016601)2.76254748
172cellular response to topologically incorrect protein (GO:0035967)2.76177942
173regulation of peptide hormone secretion (GO:0090276)2.75330635
174regulation of cilium assembly (GO:1902017)2.74801296
175regulation of T-helper 2 cell differentiation (GO:0045628)2.74725541
176phagocytosis, recognition (GO:0006910)2.74708042
177lipopolysaccharide-mediated signaling pathway (GO:0031663)2.74009213
178protein targeting to Golgi (GO:0000042)2.73611862
179apoptotic cell clearance (GO:0043277)2.73512408
180response to thyroid hormone (GO:0097066)2.73254931
181negative regulation of bone resorption (GO:0045779)2.73029107
182cellular zinc ion homeostasis (GO:0006882)2.71558784
183granulocyte activation (GO:0036230)2.71256466
184regulation of peptide secretion (GO:0002791)2.69996136
185endoplasmic reticulum unfolded protein response (GO:0030968)2.69893000
186DNA methylation involved in gamete generation (GO:0043046)2.69671143
187positive regulation of peptide hormone secretion (GO:0090277)2.69516701
188monocyte chemotaxis (GO:0002548)2.67997343
189cilium organization (GO:0044782)2.66382248
190ruffle organization (GO:0031529)2.65299681
191response to unfolded protein (GO:0006986)2.64619894
192cilium assembly (GO:0042384)2.64117199
193response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.64089693
194response to host (GO:0075136)2.64089693
195response to host defenses (GO:0052200)2.64089693
196positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.61031081
197regulation of phagocytosis (GO:0050764)2.60256042
198cell wall macromolecule catabolic process (GO:0016998)12.2194504
199cell wall macromolecule metabolic process (GO:0044036)12.2194504
200fusion of sperm to egg plasma membrane (GO:0007342)11.1190474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse6.60165032
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.29890462
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.22625874
4NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human4.21625459
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.90576942
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.85246700
7IRF8_27001747_Chip-Seq_BMDM_Mouse3.74496368
8SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.49105861
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.48515837
10PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.39987386
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.14381651
12Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.10208191
13VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.85805935
14SCL_19346495_ChIP-Seq_HPC-7_Human2.73951496
15DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.72870753
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.69335567
17SPI1_23127762_ChIP-Seq_K562_Human2.61138329
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.51168142
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.40720239
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27103030
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23417195
22VDR_24763502_ChIP-Seq_THP-1_Human2.21010653
23CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.20446269
24VDR_24787735_ChIP-Seq_THP-1_Human2.18683342
25ZNF274_21170338_ChIP-Seq_K562_Hela2.13267245
26EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human2.03299366
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99207907
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.97275973
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.96734694
30SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.96558150
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.94235377
32VDR_21846776_ChIP-Seq_THP-1_Human1.92008649
33STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81671250
34EZH2_22144423_ChIP-Seq_EOC_Human1.81382852
35VDR_22108803_ChIP-Seq_LS180_Human1.81117513
36LXR_22292898_ChIP-Seq_THP-1_Human1.79989211
37KDM2B_26808549_Chip-Seq_SUP-B15_Human1.79758518
38SPI1_23547873_ChIP-Seq_NB4_Human1.77632213
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.77086250
40RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.75763783
41TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.74540359
42PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72976699
43BRD4_27068464_Chip-Seq_AML-cells_Mouse1.71856913
44PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.69601080
45DROSHA_22980978_ChIP-Seq_HELA_Human1.65733993
46TAL1_26923725_Chip-Seq_HPCs_Mouse1.62984834
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.61989767
48GATA1_19941827_ChIP-Seq_MEL_Mouse1.61504557
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.60145184
50PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.57819782
51FLI1_21867929_ChIP-Seq_TH2_Mouse1.55726251
52NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.55017971
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50302111
54LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.50022082
55REST_21632747_ChIP-Seq_MESCs_Mouse1.49691411
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.49083609
57KDM2B_26808549_Chip-Seq_REH_Human1.48082105
58GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.48047488
59GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.47725303
60RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47640160
61KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.47449712
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.45385080
63RUNX_20019798_ChIP-Seq_JUKART_Human1.44178613
64SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.43855048
65MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.41893390
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.41284160
67GATA3_21867929_ChIP-Seq_CD8_Mouse1.40936022
68NANOG_18555785_Chip-Seq_ESCs_Mouse1.38727926
69RUNX1_26923725_Chip-Seq_HPCs_Mouse1.38180271
70PU_27001747_Chip-Seq_BMDM_Mouse1.37295995
71WDR5_24793694_ChIP-Seq_LNCAP_Human1.37161729
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36948792
73NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.36739928
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.36380796
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.34571952
76GF1_26923725_Chip-Seq_HPCs_Mouse1.33955470
77CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32454712
78CRX_20693478_ChIP-Seq_RETINA_Mouse1.31108851
79KDM2B_26808549_Chip-Seq_K562_Human1.29928461
80LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.29689941
81CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.29300004
82EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.29012598
83STAT1_17558387_ChIP-Seq_HELA_Human1.28161463
84KAP1_22055183_ChIP-Seq_ESCs_Mouse1.27235528
85P53_22387025_ChIP-Seq_ESCs_Mouse1.26932734
86PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26092380
87IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.24985185
88TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24027077
89ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23166333
90GATA1_19941826_ChIP-Seq_K562_Human1.22588249
91STAT3_18555785_Chip-Seq_ESCs_Mouse1.21973289
92GF1B_26923725_Chip-Seq_HPCs_Mouse1.21748704
93SOX2_22085726_ChIP-Seq_NPCs_Mouse1.21646988
94EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.21255662
95TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20721123
96ERG_20517297_ChIP-Seq_VCAP_Human1.20691329
97IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20085528
98CBP_20019798_ChIP-Seq_JUKART_Human1.20085528
99CMYC_18555785_Chip-Seq_ESCs_Mouse1.19947985
100ELK4_26923725_Chip-Seq_MESODERM_Mouse1.19769478
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.19694477
102KDM2B_26808549_Chip-Seq_DND41_Human1.19582349
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17891483
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.17246610
105FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16800145
106KLF4_18555785_Chip-Seq_ESCs_Mouse1.16460184
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15928442
108ETV2_25802403_ChIP-Seq_MESCs_Mouse1.15881698
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.14528372
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14236741
111CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14175862
112EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.14125478
113ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13793804
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.13442946
115GATA2_21666600_ChIP-Seq_HMVEC_Human1.13343465
116TCF7_22412390_ChIP-Seq_EML_Mouse1.13278032
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13269326
118STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13206609
119SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12694463
120IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.12533901
121P53_21459846_ChIP-Seq_SAOS-2_Human1.12066833
122EZH2_27294783_Chip-Seq_NPCs_Mouse1.11629668
123OCT4_18555785_Chip-Seq_ESCs_Mouse1.11047045
124GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11021992
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.10330148
126P300_18555785_Chip-Seq_ESCs_Mouse1.09205423
127GATA1_22025678_ChIP-Seq_K562_Human1.09077547
128ELF1_17652178_ChIP-ChIP_JURKAT_Human1.07526239
129GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06704670
130SMAD3_21741376_ChIP-Seq_ESCs_Human1.06671273
131CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06315957
132FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06083357
133AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05854341
134SUZ12_18555785_Chip-Seq_ESCs_Mouse1.05673052
135SMAD1_18555785_Chip-Seq_ESCs_Mouse1.04813343
136CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04506016
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04241855
138PU1_27457419_Chip-Seq_LIVER_Mouse1.04116932
139PCGF2_27294783_Chip-Seq_NPCs_Mouse1.03530715
140ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.03283548
141RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02774716
142LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01677210
143OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01612701
144FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99836776
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.99752219
146GATA2_19941826_ChIP-Seq_K562_Human0.99229500
147CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98438575
148CTCF_18555785_Chip-Seq_ESCs_Mouse0.98021178
149ELK3_25401928_ChIP-Seq_HUVEC_Human0.97718917
150FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.97625382
151SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97426948
152ESET_19884257_ChIP-Seq_ESCs_Mouse0.97005662
153RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96150823
154POU3F2_20337985_ChIP-ChIP_501MEL_Human0.94571477
155CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94550595
156RARA_24833708_ChIP-Seq_LIVER_Mouse0.93783004
157ZFX_18555785_Chip-Seq_ESCs_Mouse0.93612850
158CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93034000
159RUNX1_27457419_Chip-Seq_LIVER_Mouse0.93032675
160TDRD3_21172665_ChIP-Seq_MCF-7_Human0.91068676
161EGR1_19374776_ChIP-ChIP_THP-1_Human0.90851658
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.90789145
163KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.90701420
164GATA3_21867929_ChIP-Seq_TH1_Mouse0.90443761
165ESR2_21235772_ChIP-Seq_MCF-7_Human0.89816555
166MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.89531114
167SPI1_20517297_ChIP-Seq_HL60_Human0.88830833
168SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88827266
169BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.88519019
170VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.87585468
171NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.86825729
172BCL6_27268052_Chip-Seq_Bcells_Human0.86344408
173ERG_21242973_ChIP-ChIP_JURKAT_Human0.84647605
174TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81957359
175DNAJC2_21179169_ChIP-ChIP_NT2_Human0.81706787
176MAF_26560356_Chip-Seq_TH1_Human0.81341601
177GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80361820
178EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.79061289
179BCOR_27268052_Chip-Seq_Bcells_Human0.76889043
180KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76462044
181LXR_22158963_ChIP-Seq_LIVER_Mouse0.74846892
182STAT1_20625510_ChIP-Seq_HELA_Human0.74789914
183SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.73294475
184KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.72680706
185SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.70519895
186MITF_21258399_ChIP-Seq_MELANOMA_Human0.70121113
187SMC4_20622854_ChIP-Seq_HELA_Human0.69650416
188KDM2B_26808549_Chip-Seq_JURKAT_Human0.69135298
189CTCF_27219007_Chip-Seq_ERYTHROID_Human0.68024364
190PU.1_20513432_ChIP-Seq_Bcells_Mouse0.67808805

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization9.43036938
2MP0004043_abnormal_pH_regulation4.23952810
3MP0009780_abnormal_chondrocyte_physiolo3.96284603
4MP0002693_abnormal_pancreas_physiology3.84553975
5MP0002877_abnormal_melanocyte_morpholog3.74115000
6MP0003283_abnormal_digestive_organ3.68083455
7MP0010386_abnormal_urinary_bladder3.65001689
8MP0006082_CNS_inflammation3.59527871
9MP0002909_abnormal_adrenal_gland3.53322448
10MP0003183_abnormal_peptide_metabolism3.47031174
11MP0003303_peritoneal_inflammation3.43064760
12MP0005379_endocrine/exocrine_gland_phen3.40086097
13MP0003690_abnormal_glial_cell3.39663887
14MP0003698_abnormal_male_reproductive3.21033792
15MP0001944_abnormal_pancreas_morphology3.21017372
16MP0001929_abnormal_gametogenesis3.06891626
17MP0009840_abnormal_foam_cell3.03733235
18MP0005671_abnormal_response_to2.83972459
19MP0002419_abnormal_innate_immunity2.82802829
20MP0003436_decreased_susceptibility_to2.82543915
21MP0000343_altered_response_to2.81399888
22MP0005167_abnormal_blood-brain_barrier2.71396126
23MP0000604_amyloidosis2.67194681
24MP0002837_dystrophic_cardiac_calcinosis2.63420080
25MP0000013_abnormal_adipose_tissue2.56162810
26MP0003191_abnormal_cellular_cholesterol2.52658757
27MP0003075_altered_response_to2.44262069
28MP0003724_increased_susceptibility_to2.43340277
29MP0005464_abnormal_platelet_physiology2.43000262
30MP0009278_abnormal_bone_marrow2.37251321
31MP0002148_abnormal_hypersensitivity_rea2.31209647
32MP0005387_immune_system_phenotype2.28243886
33MP0001790_abnormal_immune_system2.28243886
34MP0005220_abnormal_exocrine_pancreas2.24150733
35MP0001835_abnormal_antigen_presentation2.22559422
36MP0002998_abnormal_bone_remodeling2.21879424
37MP0000685_abnormal_immune_system2.20999659
38MP0000920_abnormal_myelination2.16975139
39MP0001533_abnormal_skeleton_physiology2.12564260
40MP0005025_abnormal_response_to2.10280409
41MP0006072_abnormal_retinal_apoptosis2.08689041
42MP0009785_altered_susceptibility_to2.06905203
43MP0005000_abnormal_immune_tolerance2.04190895
44MP0008877_abnormal_DNA_methylation2.04100128
45MP0002653_abnormal_ependyma_morphology1.97452715
46MP0005670_abnormal_white_adipose1.95124358
47MP0002078_abnormal_glucose_homeostasis1.93889989
48MP0002452_abnormal_antigen_presenting1.91554975
49MP0003329_amyloid_beta_deposits1.91053703
50MP0002723_abnormal_immune_serum1.89365735
51MP0001545_abnormal_hematopoietic_system1.85796388
52MP0005397_hematopoietic_system_phenotyp1.85796388
53MP0008004_abnormal_stomach_pH1.84762839
54MP0002928_abnormal_bile_duct1.82801574
55MP0001765_abnormal_ion_homeostasis1.79938021
56MP0000678_abnormal_parathyroid_gland1.74822700
57MP0005646_abnormal_pituitary_gland1.70209670
58MP0002234_abnormal_pharynx_morphology1.69925368
59MP0002161_abnormal_fertility/fecundity1.66984972
60MP0001800_abnormal_humoral_immune1.64629976
61MP0003195_calcinosis1.59644478
62MP0003828_pulmonary_edema1.56912901
63MP0001819_abnormal_immune_cell1.56212625
64MP0009764_decreased_sensitivity_to1.55500021
65MP0001986_abnormal_taste_sensitivity1.55360137
66MP0002420_abnormal_adaptive_immunity1.54029172
67MP0000462_abnormal_digestive_system1.52940724
68MP0002210_abnormal_sex_determination1.51009254
69MP0004264_abnormal_extraembryonic_tissu1.46724753
70MP0001853_heart_inflammation1.45328821
71MP0001145_abnormal_male_reproductive1.44045533
72MP0001845_abnormal_inflammatory_respons1.38691033
73MP0003172_abnormal_lysosome_physiology1.37718204
74MP0008469_abnormal_protein_level1.36915625
75MP0005535_abnormal_body_temperature1.34420443
76MP0004510_myositis1.32077033
77MP0003634_abnormal_glial_cell1.31781113
78MP0008260_abnormal_autophagy1.28836851
79MP0005636_abnormal_mineral_homeostasis1.27733260
80MP0008961_abnormal_basal_metabolism1.26405361
81MP0005058_abnormal_lysosome_morphology1.25493776
82MP0004883_abnormal_blood_vessel1.24478285
83MP0003953_abnormal_hormone_level1.23146650
84MP0000653_abnormal_sex_gland1.22767340
85MP0002405_respiratory_system_inflammati1.22410110
86MP0005166_decreased_susceptibility_to1.17150831
87MP0005310_abnormal_salivary_gland1.16859128
88MP0001542_abnormal_bone_strength1.16508955
89MP0003448_altered_tumor_morphology1.13358712
90MP0009643_abnormal_urine_homeostasis1.12456274
91MP0003252_abnormal_bile_duct1.10917663
92MP0003890_abnormal_embryonic-extraembry1.10754579
93MP0004270_analgesia1.10306178
94MP0005165_increased_susceptibility_to1.06437289
95MP0003868_abnormal_feces_composition1.04854977
96MP0004233_abnormal_muscle_weight1.04407226
97MP0002638_abnormal_pupillary_reflex0.99880126
98MP0000716_abnormal_immune_system0.99738389
99MP0004947_skin_inflammation0.98467389
100MP0005257_abnormal_intraocular_pressure0.97726111
101MP0005365_abnormal_bile_salt0.97009934
102MP0009333_abnormal_splenocyte_physiolog0.95279164
103MP0002138_abnormal_hepatobiliary_system0.94785897
104MP0000003_abnormal_adipose_tissue0.94583100
105MP0005164_abnormal_response_to0.94149100
106MP0000858_altered_metastatic_potential0.92877994
107MP0003631_nervous_system_phenotype0.92654770
108MP0002896_abnormal_bone_mineralization0.91871070
109MP0002876_abnormal_thyroid_physiology0.90212761
110MP0003632_abnormal_nervous_system0.90156487
111MP0009763_increased_sensitivity_to0.88074217
112MP0002090_abnormal_vision0.85650144
113MP0002064_seizures0.85345662
114MP0010155_abnormal_intestine_physiology0.85220047
115MP0002139_abnormal_hepatobiliary_system0.84611583
116MP0003879_abnormal_hair_cell0.84534423
117MP0000249_abnormal_blood_vessel0.84353266
118MP0003122_maternal_imprinting0.83628714
119MP0001851_eye_inflammation0.83337069
120MP0002163_abnormal_gland_morphology0.82988673
121MP0005645_abnormal_hypothalamus_physiol0.82680355
122MP0002160_abnormal_reproductive_system0.82082679
123MP0002277_abnormal_respiratory_mucosa0.79732032
124MP0000689_abnormal_spleen_morphology0.79128218
125MP0000538_abnormal_urinary_bladder0.79103586
126MP0006054_spinal_hemorrhage0.78962926
127MP0005647_abnormal_sex_gland0.77567647
128MP0006036_abnormal_mitochondrial_physio0.77112751
129MP0005253_abnormal_eye_physiology0.76805638
130MP0008874_decreased_physiological_sensi0.75408143
131MP0001756_abnormal_urination0.75196894
132MP0005595_abnormal_vascular_smooth0.74090661
133MP0003300_gastrointestinal_ulcer0.73179751
134MP0009115_abnormal_fat_cell0.72715895
135MP0005390_skeleton_phenotype0.72246347
136MP0005451_abnormal_body_composition0.71909807
137MP0005389_reproductive_system_phenotype0.71773793
138MP0001270_distended_abdomen0.71404633
139MP0003279_aneurysm0.71228551
140MP0002398_abnormal_bone_marrow0.70783154
141MP0003453_abnormal_keratinocyte_physiol0.70229528
142MP0000465_gastrointestinal_hemorrhage0.69238158
143MP0002429_abnormal_blood_cell0.68676941
144MP0000613_abnormal_salivary_gland0.68530922
145MP0005584_abnormal_enzyme/coenzyme_acti0.68374414
146MP0000639_abnormal_adrenal_gland0.67223716
147MP0002229_neurodegeneration0.67168710
148MP0003091_abnormal_cell_migration0.66791047
149MP0001984_abnormal_olfaction0.66398395
150MP0009672_abnormal_birth_weight0.65429491
151MP0000631_abnormal_neuroendocrine_gland0.65177622
152MP0002118_abnormal_lipid_homeostasis0.64198209
153MP0003656_abnormal_erythrocyte_physiolo0.63820091
154MP0003045_fibrosis0.62694545
155MP0005448_abnormal_energy_balance0.61474820
156MP0005377_hearing/vestibular/ear_phenot0.60483956
157MP0003878_abnormal_ear_physiology0.60483956
158MP0001502_abnormal_circadian_rhythm0.60075980
159MP0005375_adipose_tissue_phenotype0.58920602
160MP0003119_abnormal_digestive_system0.57967328
161MP0001970_abnormal_pain_threshold0.57836993
162MP0009642_abnormal_blood_homeostasis0.57187609
163MP0003959_abnormal_lean_body0.56525615
164MP0001486_abnormal_startle_reflex0.55897394
165MP0001764_abnormal_homeostasis0.54640218
166MP0002722_abnormal_immune_system0.54382580
167MP0005334_abnormal_fat_pad0.53634731
168MP0001661_extended_life_span0.53560821
169MP0000747_muscle_weakness0.53029192
170MP0005023_abnormal_wound_healing0.51753294
171MP0001324_abnormal_eye_pigmentation0.50937821
172MP0003866_abnormal_defecation0.49249430
173MP0008058_abnormal_DNA_repair0.48414763
174MP0002009_preneoplasia0.46937365
175MP0002971_abnormal_brown_adipose0.46031788
176MP0000681_abnormal_thyroid_gland0.43007467
177MP0000230_abnormal_systemic_arterial0.42923660
178MP0003795_abnormal_bone_structure0.42544681
179MP0005408_hypopigmentation0.41229997
180MP0002970_abnormal_white_adipose0.40231245
181MP0002269_muscular_atrophy0.39489373
182MP0005666_abnormal_adipose_tissue0.39191778
183MP0003633_abnormal_nervous_system0.39150193
184MP0004036_abnormal_muscle_relaxation0.39128722
185MP0000609_abnormal_liver_physiology0.38420386
186MP0000358_abnormal_cell_content/0.38338468

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)8.25986358
2Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.96861096
3Absent/shortened dynein arms (HP:0200106)7.87054508
4Dynein arm defect of respiratory motile cilia (HP:0012255)7.87054508
5Glomerulonephritis (HP:0000099)7.12410236
6Chronic bronchitis (HP:0004469)7.05439245
7Abnormality of liposaccharide metabolism (HP:0010968)6.26100522
8Abnormality of glycosphingolipid metabolism (HP:0004343)6.26100522
9Abnormality of glycolipid metabolism (HP:0010969)6.26100522
10Hyperinsulinemic hypoglycemia (HP:0000825)5.92046473
11Complement deficiency (HP:0004431)5.90937230
12Abnormal respiratory motile cilium physiology (HP:0012261)5.65247372
13Abnormal respiratory epithelium morphology (HP:0012253)5.54346381
14Abnormal respiratory motile cilium morphology (HP:0005938)5.54346381
15Mutism (HP:0002300)5.36401607
16Disinhibition (HP:0000734)5.12935246
17Hypoglycemic seizures (HP:0002173)5.11327957
18Vacuolated lymphocytes (HP:0001922)5.06329953
19Rhinitis (HP:0012384)5.00437125
20Axonal loss (HP:0003447)4.92360361
21Increased cerebral lipofuscin (HP:0011813)4.76499412
22Spontaneous hematomas (HP:0007420)4.61293644
23Recurrent bacterial skin infections (HP:0005406)4.57206130
24Symptomatic seizures (HP:0011145)4.56510707
25Infertility (HP:0000789)4.56427963
26Abnormality of complement system (HP:0005339)4.48792659
27Recurrent abscess formation (HP:0002722)4.48069996
28Abnormal ciliary motility (HP:0012262)4.38888601
29Agnosia (HP:0010524)4.37657322
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)4.32393544
31Nasal polyposis (HP:0100582)4.29484659
32Hypoglycemic coma (HP:0001325)4.22064128
33Upper motor neuron abnormality (HP:0002127)4.20100759
34Abnormality of macrophages (HP:0004311)4.12628707
35Neurofibrillary tangles (HP:0002185)3.97693067
36Bronchitis (HP:0012387)3.97454401
37Increased neuronal autofluorescent lipopigment (HP:0002074)3.88132553
38Medial flaring of the eyebrow (HP:0010747)3.81789968
39Insulin-resistant diabetes mellitus (HP:0000831)3.61627649
40Absent eyebrow (HP:0002223)3.60592867
41Loss of speech (HP:0002371)3.60025899
42Recurrent gram-negative bacterial infections (HP:0005420)3.59423403
43Nephritis (HP:0000123)3.56267881
44Decreased circulating renin level (HP:0003351)3.50443622
45Bronchiectasis (HP:0002110)3.49915061
46Abnormality of the nasal mucosa (HP:0000433)3.43482147
47Eczematoid dermatitis (HP:0000976)3.36950292
48Neuronal loss in central nervous system (HP:0002529)3.32557856
49Abnormality of the pancreatic islet cells (HP:0006476)3.26217807
50Abnormality of endocrine pancreas physiology (HP:0012093)3.26217807
51Hyperglycemia (HP:0003074)3.20483222
52Recurrent skin infections (HP:0001581)3.16454561
53Mucopolysacchariduria (HP:0008155)3.00365674
54Urinary glycosaminoglycan excretion (HP:0003541)3.00365674
55Mediastinal lymphadenopathy (HP:0100721)2.97280639
56Nephronophthisis (HP:0000090)2.94782219
57Late onset (HP:0003584)2.94501820
58Inappropriate behavior (HP:0000719)2.91451859
59Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.88773355
60Ketoacidosis (HP:0001993)2.81313746
61Pathologic fracture (HP:0002756)2.80582269
62Abnormality of the vasculature of the conjunctiva (HP:0008054)2.79589797
63Personality changes (HP:0000751)2.79202374
64Gingivitis (HP:0000230)2.76193834
65Cerebral inclusion bodies (HP:0100314)2.75190240
66Nuclear cataract (HP:0100018)2.73120659
67Male infertility (HP:0003251)2.71198403
68Abnormal pancreas size (HP:0012094)2.70939050
69Basal ganglia calcification (HP:0002135)2.69021439
70Apathy (HP:0000741)2.68135512
71Large for gestational age (HP:0001520)2.66954727
72Amyloidosis (HP:0011034)2.64745751
73Abnormality of polysaccharide metabolism (HP:0011012)2.64343101
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.64343101
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.64343101
76Purpura (HP:0000979)2.62730689
77Hyperkalemia (HP:0002153)2.59924101
78Pancreatic islet-cell hyperplasia (HP:0004510)2.59140623
79Dysostosis multiplex (HP:0000943)2.57007547
80Hypoplastic labia majora (HP:0000059)2.56317161
81Diminished motivation (HP:0000745)2.56038502
82Dementia (HP:0000726)2.53229330
83Popliteal pterygium (HP:0009756)2.43826224
84Hyperactive renin-angiotensin system (HP:0000841)2.43801776
85Facial cleft (HP:0002006)2.41006835
86Congenital primary aphakia (HP:0007707)2.40440290
87Peripheral demyelination (HP:0011096)2.38083313
88Myositis (HP:0100614)2.36510629
89Abnormality of midbrain morphology (HP:0002418)2.36274827
90Molar tooth sign on MRI (HP:0002419)2.36274827
91Gait imbalance (HP:0002141)2.35227335
92Insulin resistance (HP:0000855)2.33058054
93Intestinal atresia (HP:0011100)2.32943735
94Orchitis (HP:0100796)2.32387112
95Chronic mucocutaneous candidiasis (HP:0002728)2.31642906
96Recurrent cutaneous fungal infections (HP:0011370)2.31642906
97Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.31244329
98Pustule (HP:0200039)2.28682706
99Abnormality of the labia majora (HP:0012881)2.28535283
100Cerebral aneurysm (HP:0004944)2.27924359
101Hypokalemia (HP:0002900)2.24320910
102Memory impairment (HP:0002354)2.24190888
103Absent eyelashes (HP:0000561)2.23115786
104Global brain atrophy (HP:0002283)2.19069596
105Supranuclear gaze palsy (HP:0000605)2.16511605
106Nephrogenic diabetes insipidus (HP:0009806)2.16482678
107Hematochezia (HP:0002573)2.16074749
108Autoimmune thrombocytopenia (HP:0001973)2.15870940
109Abnormality of calcium-phosphate metabolism (HP:0100530)2.14089608
110Abnormality of the renal medulla (HP:0100957)2.12959779
111Abnormality of the periventricular white matter (HP:0002518)2.10997822
112Chronic obstructive pulmonary disease (HP:0006510)2.10770533
113Obstructive lung disease (HP:0006536)2.10770533
114Progressive visual loss (HP:0000529)2.10656745
115Postural instability (HP:0002172)2.09346282
116Cystic liver disease (HP:0006706)2.09135799
117J-shaped sella turcica (HP:0002680)2.05619983
118Retinal atrophy (HP:0001105)2.04761370
119Abnormality of the intrinsic pathway (HP:0010989)2.04033968
120Esophageal neoplasm (HP:0100751)2.03904045
121Neoplasm of head and neck (HP:0012288)2.03904045
122Cellulitis (HP:0100658)2.03437732
123Recurrent fungal infections (HP:0002841)2.01989589
124Diplopia (HP:0000651)2.01608779
125Abnormality of binocular vision (HP:0011514)2.01608779
126Median cleft lip (HP:0000161)2.01401218
127Progressive neurologic deterioration (HP:0002344)2.01354765
128Rapidly progressive (HP:0003678)1.99692962
129Abnormal spermatogenesis (HP:0008669)1.96971831
130Bone pain (HP:0002653)1.96160464
131Increased CSF protein (HP:0002922)1.95821847
132Joint hemorrhage (HP:0005261)1.94892909
133Type II lissencephaly (HP:0007260)1.94714964
134Urinary incontinence (HP:0000020)1.94181802
135Ketosis (HP:0001946)1.93125401
136Recurrent bronchitis (HP:0002837)1.92131172
137Abnormality of potassium homeostasis (HP:0011042)1.91937618
138Epistaxis (HP:0000421)1.91146302
139Myocardial infarction (HP:0001658)1.91136466
140Retrobulbar optic neuritis (HP:0100654)1.91105270
141Optic neuritis (HP:0100653)1.91105270
142Abnormality of aromatic amino acid family metabolism (HP:0004338)1.90367856
143Congenital hepatic fibrosis (HP:0002612)1.88010155
144Abnormality of the distal phalanges of the toes (HP:0010182)1.87728906
145Thick nail (HP:0001805)1.87050988
146Slow saccadic eye movements (HP:0000514)1.86599723
147Spondylolisthesis (HP:0003302)1.85692688
148Premature loss of primary teeth (HP:0006323)1.85688249
149Stomatitis (HP:0010280)1.84802961
150Hypokalemic alkalosis (HP:0001949)1.83781244
151Generalized aminoaciduria (HP:0002909)1.83689279
152Conjunctival telangiectasia (HP:0000524)1.83350843
153Aplasia/Hypoplasia of the lens (HP:0008063)1.83073391
154Vaginal atresia (HP:0000148)1.83006971
155Centrally nucleated skeletal muscle fibers (HP:0003687)1.82415665
156Hepatosplenomegaly (HP:0001433)1.82211477
157Colitis (HP:0002583)1.80915627
158Abnormality of renin-angiotensin system (HP:0000847)1.79419420
159Papillary thyroid carcinoma (HP:0002895)1.79095087
160Hemoptysis (HP:0002105)1.78490925
161Thoracolumbar scoliosis (HP:0002944)1.78251746
162Conjugated hyperbilirubinemia (HP:0002908)1.77959332
163Recurrent sinusitis (HP:0011108)1.77813517
164Asymmetric septal hypertrophy (HP:0001670)1.77548084
165Vertebral compression fractures (HP:0002953)1.77427594
166Recurrent otitis media (HP:0000403)1.77024248
167Thoracic kyphosis (HP:0002942)1.75865617
168Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73615859
169Abnormal protein N-linked glycosylation (HP:0012347)1.73615859
170Abnormal protein glycosylation (HP:0012346)1.73615859
171Abnormal glycosylation (HP:0012345)1.73615859
172Meningitis (HP:0001287)1.72707652
173Genital tract atresia (HP:0001827)1.71411245
174Rigidity (HP:0002063)1.70078087
175Limb hypertonia (HP:0002509)1.68755709
176Pheochromocytoma (HP:0002666)1.68746408
177Peripheral hypomyelination (HP:0007182)1.68077131
178Abnormality of the basal ganglia (HP:0002134)1.66871825
179Pancreatic fibrosis (HP:0100732)1.64923090
180Exocrine pancreatic insufficiency (HP:0001738)1.62531208
181Dysautonomia (HP:0002459)1.62372030
182Chronic sinusitis (HP:0011109)1.61449957
183Abnormality of chloride homeostasis (HP:0011422)1.59310261
184Impaired smooth pursuit (HP:0007772)1.59250627
185Glucose intolerance (HP:0000833)1.58204873
186Poor coordination (HP:0002370)1.57528669
187Abnormality of the renal cortex (HP:0011035)1.56224875
188Lower limb hyperreflexia (HP:0002395)1.55719969
189True hermaphroditism (HP:0010459)1.55361980
190Agitation (HP:0000713)1.54683853
191Hypothermia (HP:0002045)1.54646092

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRKD35.34001298
2INSRR4.95750718
3PASK4.67198318
4MAP3K24.66231052
5PDK34.63240239
6PDK44.63240239
7TGFBR24.51924976
8FRK4.03338222
9BLK3.91597643
10MAP3K33.62041550
11TESK13.60923816
12CSF1R3.20514594
13GRK72.89306056
14PDK22.82013706
15MAP3K132.64277071
16MAPK152.62807415
17TAOK32.54906695
18CAMK1D2.31882609
19TYK22.22128183
20FES2.13332288
21WNK42.02644109
22MAP3K141.99505122
23MOS1.96151277
24ICK1.83895276
25HIPK21.78930877
26FGR1.61347813
27CSK1.53414543
28IRAK11.46594339
29DYRK1B1.46339680
30NEK61.42794833
31JAK31.40323956
32ERN11.39198101
33TNK21.36776014
34TBK11.36273290
35MAP2K31.27450260
36MAP4K11.24126342
37MAP3K111.23128905
38PRPF4B1.22583037
39FLT31.16792327
40MAPK121.10601821
41NEK91.09387073
42KIT1.09202154
43CDK61.08512807
44AKT31.05219871
45CDK121.00772538
46CDC42BPA0.96844768
47LYN0.96805021
48DDR20.96383855
49NLK0.95546886
50ARAF0.94611466
51MATK0.91164650
52SIK20.90182487
53RIPK40.90132882
54KSR20.88543660
55MARK20.86560734
56BRSK20.86058820
57ERBB30.83332012
58STK380.83019908
59ACVR1B0.82300004
60MAP2K20.82154758
61MAPK70.81598172
62NME20.81476930
63HCK0.80319508
64BMPR20.79571665
65PDK10.79285730
66NTRK30.78287322
67IRAK20.77480148
68IKBKB0.77106173
69ABL20.76683427
70WNK10.74713304
71MAP3K10.74227141
72NTRK10.72882403
73CAMKK20.72481725
74CAMK40.72391030
75LCK0.69665937
76RIPK10.69154820
77PINK10.65823349
78RPS6KB10.64653732
79IKBKE0.63878402
80PTK2B0.61848808
81PRKCH0.61612517
82YES10.60873795
83TESK20.60088354
84BRD40.59676852
85BRAF0.58871269
86TAOK10.56049451
87STK100.55965417
88NTRK20.55695874
89PKN10.55587358
90PDPK10.55539912
91IRAK30.54675844
92CAMK10.53766132
93EIF2AK30.53751301
94TYRO30.53639546
95PTK60.53428240
96IRAK40.51992344
97TAOK20.51732764
98UHMK10.51620567
99TXK0.51501230
100PRKCI0.50486607
101STK390.49219791
102PRKCG0.49176750
103ADRBK20.47131164
104MARK30.47078889
105EPHA30.46962314
106PTK20.46927393
107EPHA40.46406308
108DAPK20.45734688
109PIM20.45226174
110STK38L0.43175421
111MAP3K90.42946459
112SGK30.42090928
113MAP3K50.41759746
114BCKDK0.41566190
115FYN0.41486514
116BMPR1B0.41466489
117PRKCD0.40155661
118CAMK2G0.40093620
119PDGFRA0.39641723
120ADRBK10.39619135
121PRKD10.38515980
122SGK20.38389416
123PRKAA10.37419192
124PRKD20.36803988
125MTOR0.36553618
126PRKCZ0.35529372
127PDGFRB0.34799273
128SCYL20.33522786
129PRKAA20.32779628
130PAK30.32421990
131ABL10.32105739
132EGFR0.31779928
133JAK20.30724752
134ITK0.28614156
135PLK40.26869237
136PRKACG0.26842399
137MET0.26118786
138CAMKK10.24878366
139PNCK0.24330535
140DYRK30.24324100
141PRKG20.24128748
142TRIB30.23491881
143PRKCE0.23471950
144RPS6KA20.23194790
145WNK30.23022205
146VRK10.23002563
147ATM0.22273099
148JAK10.22212050
149IGF1R0.21858103
150GSK3A0.20913225
151CSNK1A10.19393918
152PRKDC0.19162854
153CHEK20.18693289
154NEK20.18542937
155RET0.16992193
156PRKCQ0.16873253
157TEC0.16736891
158PRKG10.16399929
159PIK3CG0.16151397
160MELK0.15080748
161ZAP700.14724455
162BTK0.13585993
163BRSK10.13478852
164LMTK20.13472465
165PRKACA0.13360911
166FER0.11055749
167SYK0.10691382
168CAMK1G0.09778594

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049508.14081387
2Protein export_Homo sapiens_hsa030605.31505139
3Staphylococcus aureus infection_Homo sapiens_hsa051504.28924949
4Sulfur metabolism_Homo sapiens_hsa009204.02177285
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.42180836
6Selenocompound metabolism_Homo sapiens_hsa004502.82455130
7Osteoclast differentiation_Homo sapiens_hsa043802.79422893
8Insulin secretion_Homo sapiens_hsa049112.72406214
9Carbohydrate digestion and absorption_Homo sapiens_hsa049732.55394835
10Glycosaminoglycan degradation_Homo sapiens_hsa005312.52633877
11Leishmaniasis_Homo sapiens_hsa051402.45847256
12Pertussis_Homo sapiens_hsa051332.17511978
13Tuberculosis_Homo sapiens_hsa051522.16443187
14Complement and coagulation cascades_Homo sapiens_hsa046102.08055257
15Rheumatoid arthritis_Homo sapiens_hsa053231.92901145
16N-Glycan biosynthesis_Homo sapiens_hsa005101.89586137
17Toll-like receptor signaling pathway_Homo sapiens_hsa046201.88745746
18Vibrio cholerae infection_Homo sapiens_hsa051101.83265041
19Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.82964147
20Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.79927623
21Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70314677
22Glucagon signaling pathway_Homo sapiens_hsa049221.66240597
23Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.64666527
24Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.57872348
25Type II diabetes mellitus_Homo sapiens_hsa049301.56378309
26Asthma_Homo sapiens_hsa053101.44563317
27Other glycan degradation_Homo sapiens_hsa005111.43753963
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.41977180
29SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40543659
30Allograft rejection_Homo sapiens_hsa053301.39843729
31Linoleic acid metabolism_Homo sapiens_hsa005911.36953345
32Type I diabetes mellitus_Homo sapiens_hsa049401.36865118
33Amphetamine addiction_Homo sapiens_hsa050311.34659768
34B cell receptor signaling pathway_Homo sapiens_hsa046621.34482499
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33570649
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.32609792
37Collecting duct acid secretion_Homo sapiens_hsa049661.28542936
38Cocaine addiction_Homo sapiens_hsa050301.28081531
39Malaria_Homo sapiens_hsa051441.27968043
40Graft-versus-host disease_Homo sapiens_hsa053321.25787051
41Basal transcription factors_Homo sapiens_hsa030221.20805771
42Taste transduction_Homo sapiens_hsa047421.18927136
43Autoimmune thyroid disease_Homo sapiens_hsa053201.17772131
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17130346
45Lysosome_Homo sapiens_hsa041421.16800869
46Toxoplasmosis_Homo sapiens_hsa051451.16757870
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.13640071
48Salmonella infection_Homo sapiens_hsa051321.13063813
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.12665724
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.09285841
51Chemokine signaling pathway_Homo sapiens_hsa040621.09093340
52Hematopoietic cell lineage_Homo sapiens_hsa046401.07634931
53Intestinal immune network for IgA production_Homo sapiens_hsa046721.05062875
54Pyruvate metabolism_Homo sapiens_hsa006201.02202754
55Thyroid hormone synthesis_Homo sapiens_hsa049181.01706223
56Platelet activation_Homo sapiens_hsa046111.00736049
57Sphingolipid signaling pathway_Homo sapiens_hsa040711.00616395
58Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99847983
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.94597945
60Fructose and mannose metabolism_Homo sapiens_hsa000510.93486457
61Propanoate metabolism_Homo sapiens_hsa006400.90076713
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.88854276
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.88424641
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87156387
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.86200321
66Influenza A_Homo sapiens_hsa051640.85347739
67Pancreatic secretion_Homo sapiens_hsa049720.85198908
68Long-term potentiation_Homo sapiens_hsa047200.85105834
69Antigen processing and presentation_Homo sapiens_hsa046120.84173268
70Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.83647384
71Endocytosis_Homo sapiens_hsa041440.82119795
72Amoebiasis_Homo sapiens_hsa051460.82031720
73Insulin resistance_Homo sapiens_hsa049310.81506603
74GnRH signaling pathway_Homo sapiens_hsa049120.80450365
75Galactose metabolism_Homo sapiens_hsa000520.79202042
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.78772133
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78496519
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.76856893
79ABC transporters_Homo sapiens_hsa020100.74989972
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73383483
81Synaptic vesicle cycle_Homo sapiens_hsa047210.71759133
82TNF signaling pathway_Homo sapiens_hsa046680.70402797
83Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70124528
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.69938242
85Viral myocarditis_Homo sapiens_hsa054160.66901101
86Folate biosynthesis_Homo sapiens_hsa007900.65602044
87Acute myeloid leukemia_Homo sapiens_hsa052210.64506076
88Fatty acid biosynthesis_Homo sapiens_hsa000610.63029602
89Gastric acid secretion_Homo sapiens_hsa049710.62941405
90Legionellosis_Homo sapiens_hsa051340.62099308
91Tryptophan metabolism_Homo sapiens_hsa003800.61858730
92African trypanosomiasis_Homo sapiens_hsa051430.61640480
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60180939
94Estrogen signaling pathway_Homo sapiens_hsa049150.59025574
95Sphingolipid metabolism_Homo sapiens_hsa006000.58611279
96AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56095717
97Fat digestion and absorption_Homo sapiens_hsa049750.55762897
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.55477403
99Rap1 signaling pathway_Homo sapiens_hsa040150.55159140
100Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.54836444
101Measles_Homo sapiens_hsa051620.54655420
102Dorso-ventral axis formation_Homo sapiens_hsa043200.54272971
103Mineral absorption_Homo sapiens_hsa049780.53987382
104Oxytocin signaling pathway_Homo sapiens_hsa049210.52872274
105Inositol phosphate metabolism_Homo sapiens_hsa005620.52710691
106Glutamatergic synapse_Homo sapiens_hsa047240.52118028
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.52080730
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.52017994
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.51797629
110Fatty acid degradation_Homo sapiens_hsa000710.51689404
111Systemic lupus erythematosus_Homo sapiens_hsa053220.51211189
112Phenylalanine metabolism_Homo sapiens_hsa003600.50988966
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.50543824
114Regulation of autophagy_Homo sapiens_hsa041400.49139775
115Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.48363242
116Vitamin B6 metabolism_Homo sapiens_hsa007500.48296644
117Apoptosis_Homo sapiens_hsa042100.47991503
118cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47921741
119VEGF signaling pathway_Homo sapiens_hsa043700.47077024
120Starch and sucrose metabolism_Homo sapiens_hsa005000.46279392
121Long-term depression_Homo sapiens_hsa047300.46129488
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45717170
123Renin secretion_Homo sapiens_hsa049240.45601416
124Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44448850
125Dopaminergic synapse_Homo sapiens_hsa047280.44268033
126Circadian entrainment_Homo sapiens_hsa047130.43786863
127HIF-1 signaling pathway_Homo sapiens_hsa040660.43079621
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.42826421
129PPAR signaling pathway_Homo sapiens_hsa033200.42142168
130Prolactin signaling pathway_Homo sapiens_hsa049170.41431885
131Phagosome_Homo sapiens_hsa041450.41304739
132T cell receptor signaling pathway_Homo sapiens_hsa046600.39833878
133Fatty acid metabolism_Homo sapiens_hsa012120.38839510
134Shigellosis_Homo sapiens_hsa051310.38769728
135Ether lipid metabolism_Homo sapiens_hsa005650.38605635
136Adipocytokine signaling pathway_Homo sapiens_hsa049200.36069138
137Primary bile acid biosynthesis_Homo sapiens_hsa001200.35144364
138Renal cell carcinoma_Homo sapiens_hsa052110.35116156
139Prion diseases_Homo sapiens_hsa050200.34966016
140Insulin signaling pathway_Homo sapiens_hsa049100.34820989
141Hepatitis C_Homo sapiens_hsa051600.34485033
142Salivary secretion_Homo sapiens_hsa049700.34459069
143Notch signaling pathway_Homo sapiens_hsa043300.34254421
144Glycerolipid metabolism_Homo sapiens_hsa005610.34252050
145RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33603959
146Alcoholism_Homo sapiens_hsa050340.32668946
147Purine metabolism_Homo sapiens_hsa002300.32403821
148Circadian rhythm_Homo sapiens_hsa047100.30516178
149Histidine metabolism_Homo sapiens_hsa003400.29590245
150Protein digestion and absorption_Homo sapiens_hsa049740.27631564
151Renin-angiotensin system_Homo sapiens_hsa046140.25593806
152Metabolic pathways_Homo sapiens_hsa011000.24925820
153Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.24446287
154AMPK signaling pathway_Homo sapiens_hsa041520.24041963
155Oocyte meiosis_Homo sapiens_hsa041140.22968529
156Fatty acid elongation_Homo sapiens_hsa000620.22077771
157Arachidonic acid metabolism_Homo sapiens_hsa005900.21742865
158Butanoate metabolism_Homo sapiens_hsa006500.21484138
159Cholinergic synapse_Homo sapiens_hsa047250.21277705
160Thyroid hormone signaling pathway_Homo sapiens_hsa049190.20461795
161Pentose phosphate pathway_Homo sapiens_hsa000300.20442586
162Non-homologous end-joining_Homo sapiens_hsa034500.18815672
163Huntingtons disease_Homo sapiens_hsa050160.18090176
164cAMP signaling pathway_Homo sapiens_hsa040240.17549800
165Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13974752
166Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.13318952
167Serotonergic synapse_Homo sapiens_hsa047260.13318260
168Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11248571

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