TMF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)6.66514004
2cilium movement (GO:0003341)6.34567171
3membrane repolarization during cardiac muscle cell action potential (GO:0086013)5.88420898
4potassium ion export (GO:0071435)5.87722053
5epithelial cilium movement (GO:0003351)5.81265899
6axonemal dynein complex assembly (GO:0070286)5.67589517
7membrane repolarization during action potential (GO:0086011)5.47901823
8establishment of protein localization to Golgi (GO:0072600)5.46214463
9protein targeting to Golgi (GO:0000042)5.35814001
10retrograde transport, vesicle recycling within Golgi (GO:0000301)5.02207458
11axoneme assembly (GO:0035082)4.95951503
12limb bud formation (GO:0060174)4.72290838
13presynaptic membrane assembly (GO:0097105)4.64991524
14melanin metabolic process (GO:0006582)4.53959151
15melanin biosynthetic process (GO:0042438)4.45843232
16cellular response to ethanol (GO:0071361)4.42498319
17protein localization to Golgi apparatus (GO:0034067)4.30388093
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.21357235
19multicellular organism reproduction (GO:0032504)4.00445518
20interleukin-6-mediated signaling pathway (GO:0070102)3.98984587
21acrosome reaction (GO:0007340)3.94231154
22phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.91504473
23negative regulation of execution phase of apoptosis (GO:1900118)3.80152362
24presynaptic membrane organization (GO:0097090)3.79074847
25neural tube formation (GO:0001841)3.78347545
26COPII vesicle coating (GO:0048208)3.73416517
27secondary metabolite biosynthetic process (GO:0044550)3.72731940
28GTP biosynthetic process (GO:0006183)3.72180151
29regulation of pigment cell differentiation (GO:0050932)3.67621485
30early endosome to late endosome transport (GO:0045022)3.64045930
31regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.61978333
32monoubiquitinated protein deubiquitination (GO:0035520)3.61466874
33intra-Golgi vesicle-mediated transport (GO:0006891)3.59032584
34ventricular system development (GO:0021591)3.57778252
35fusion of sperm to egg plasma membrane (GO:0007342)3.57214069
36intraciliary transport (GO:0042073)3.56849830
37interkinetic nuclear migration (GO:0022027)3.55756310
38magnesium ion transport (GO:0015693)3.53040248
39* acrosome assembly (GO:0001675)3.48761887
40appendage development (GO:0048736)3.45145482
41limb development (GO:0060173)3.45145482
42motile cilium assembly (GO:0044458)3.43603463
43* sperm motility (GO:0030317)3.40385416
44postsynaptic membrane organization (GO:0001941)3.39757578
45protein targeting to lysosome (GO:0006622)3.35800116
46establishment of protein localization to vacuole (GO:0072666)3.35800116
47protein targeting to vacuole (GO:0006623)3.35800116
48protein localization to cilium (GO:0061512)3.35365399
49microtubule depolymerization (GO:0007019)3.33485169
50short-term memory (GO:0007614)3.32474260
51ER overload response (GO:0006983)3.28245598
52negative regulation of homotypic cell-cell adhesion (GO:0034111)3.19504327
53cilium morphogenesis (GO:0060271)3.18961945
54membrane repolarization (GO:0086009)3.18131576
55cilium organization (GO:0044782)3.17038280
56cilium assembly (GO:0042384)3.14844736
57developmental pigmentation (GO:0048066)3.13257315
58histone H3-K4 trimethylation (GO:0080182)3.10673376
59protein K11-linked deubiquitination (GO:0035871)3.06023827
60regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.05056328
61UDP-N-acetylglucosamine metabolic process (GO:0006047)3.04959600
62nucleoside diphosphate phosphorylation (GO:0006165)3.04670952
63peripheral nervous system neuron development (GO:0048935)3.04429224
64regulation of cilium movement (GO:0003352)2.99293908
65left/right axis specification (GO:0070986)2.98393036
66histone mRNA catabolic process (GO:0071044)2.95881607
67hepatocyte apoptotic process (GO:0097284)2.93936970
68retina layer formation (GO:0010842)2.93207868
69female gonad development (GO:0008585)2.92665698
70otic vesicle formation (GO:0030916)2.92525992
71single fertilization (GO:0007338)2.87350861
72cell wall macromolecule catabolic process (GO:0016998)2.87108563
73cell wall macromolecule metabolic process (GO:0044036)2.87108563
74kidney morphogenesis (GO:0060993)2.82714860
75neuron cell-cell adhesion (GO:0007158)2.82629897
76male meiosis (GO:0007140)2.82328163
77DNA methylation involved in gamete generation (GO:0043046)2.81147873
78negative regulation of dendrite morphogenesis (GO:0050774)2.80937858
79iron ion import (GO:0097286)2.80047146
80piRNA metabolic process (GO:0034587)2.79879053
81Golgi to endosome transport (GO:0006895)2.78117754
82UTP biosynthetic process (GO:0006228)2.77576136
83reproduction (GO:0000003)2.77153518
84regulation of protein glycosylation (GO:0060049)2.73206858
85eye photoreceptor cell differentiation (GO:0001754)2.72835425
86photoreceptor cell differentiation (GO:0046530)2.72835425
87spermatid development (GO:0007286)2.71988594
88* cellular component assembly involved in morphogenesis (GO:0010927)2.70397154
89regulation of establishment of cell polarity (GO:2000114)2.69171099
90membrane assembly (GO:0071709)2.68202703
91cellular response to gamma radiation (GO:0071480)2.67281324
92sperm-egg recognition (GO:0035036)2.62941029
93regulation of timing of cell differentiation (GO:0048505)2.62567921
94regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.62098697
95protein localization to microtubule cytoskeleton (GO:0072698)2.60738068
96regulation of platelet aggregation (GO:0090330)2.60543356
97negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.60465024
98radial glial cell differentiation (GO:0060019)2.58338982
99peptidyl-lysine trimethylation (GO:0018023)2.57608600
100macroautophagy (GO:0016236)2.56631843
101sperm capacitation (GO:0048240)2.55879964
102sympathetic nervous system development (GO:0048485)2.51657274
103protein K63-linked deubiquitination (GO:0070536)2.50017769
104plasma membrane fusion (GO:0045026)2.47879468
105positive regulation of potassium ion transmembrane transport (GO:1901381)2.47815631
106positive regulation of synapse assembly (GO:0051965)2.46564435
107response to pheromone (GO:0019236)2.46427526
108negative regulation of keratinocyte proliferation (GO:0010839)2.46089712
109polyol catabolic process (GO:0046174)2.45983519
110nucleus localization (GO:0051647)2.45950561
111cytoplasmic mRNA processing body assembly (GO:0033962)2.45556108
112organ growth (GO:0035265)2.44429688
113activated T cell proliferation (GO:0050798)2.43854959
114SMAD protein complex assembly (GO:0007183)2.43746319
115protein heterotetramerization (GO:0051290)2.43627488
116regulation of protein polyubiquitination (GO:1902914)2.41762627
117pericardium development (GO:0060039)2.40873141
118positive regulation of protein kinase C signaling (GO:0090037)2.40792169
119intestinal epithelial cell development (GO:0060576)2.40347130
120mechanoreceptor differentiation (GO:0042490)2.38620579
121regulation of establishment or maintenance of cell polarity (GO:0032878)2.37303460
122microtubule anchoring (GO:0034453)2.36561811
123phospholipid translocation (GO:0045332)2.36374024
124lipid translocation (GO:0034204)2.36374024
125serotonin receptor signaling pathway (GO:0007210)2.35812858
126nonmotile primary cilium assembly (GO:0035058)2.35684899
127definitive hemopoiesis (GO:0060216)2.35263957
128regulation of cell maturation (GO:1903429)2.33374997
129extracellular negative regulation of signal transduction (GO:1900116)2.31046793
130extracellular regulation of signal transduction (GO:1900115)2.31046793
131regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.30942888
132branch elongation of an epithelium (GO:0060602)2.30564377
133negative regulation of myoblast differentiation (GO:0045662)2.30287452
134startle response (GO:0001964)2.29705729
135negative regulation of neurotransmitter secretion (GO:0046929)2.29554785
136ventricular cardiac muscle cell action potential (GO:0086005)2.29166658
137myelin assembly (GO:0032288)2.28179632
138mesenchymal cell differentiation involved in renal system development (GO:2001012)2.27088600
139mesenchymal cell differentiation involved in kidney development (GO:0072161)2.27088600
140sequestering of extracellular ligand from receptor (GO:0035581)2.26863778
141protein localization to vacuole (GO:0072665)2.25985077
142protein localization to lysosome (GO:0061462)2.25985077
143regulation of fibroblast apoptotic process (GO:2000269)2.25942558
144photoreceptor cell maintenance (GO:0045494)2.25835548
145guanosine-containing compound biosynthetic process (GO:1901070)2.25170170
146renal tubule morphogenesis (GO:0061333)2.24698414
147neuron fate specification (GO:0048665)2.24612384
148regulation of development, heterochronic (GO:0040034)2.24548939
149cell-cell recognition (GO:0009988)2.24082535
150axon ensheathment in central nervous system (GO:0032291)2.23980374
151central nervous system myelination (GO:0022010)2.23980374
152chondrocyte development (GO:0002063)2.23523029
153microtubule polymerization or depolymerization (GO:0031109)2.22928257
154positive regulation of potassium ion transport (GO:0043268)2.22384858
155regulation of male gonad development (GO:2000018)2.21605606
156fertilization (GO:0009566)2.19779970
157protein localization to cytoskeleton (GO:0044380)2.19134069
158regulation of alkaline phosphatase activity (GO:0010692)2.18915839
159spinal cord motor neuron differentiation (GO:0021522)2.18509566
160phenol-containing compound biosynthetic process (GO:0046189)2.18413555
161cellular response to exogenous dsRNA (GO:0071360)2.17067708
162neuronal action potential propagation (GO:0019227)2.16857380
163regulation of interferon-beta biosynthetic process (GO:0045357)2.16707888
164positive regulation of action potential (GO:0045760)2.16606061
165positive regulation of protein autophosphorylation (GO:0031954)2.15518104
166centriole replication (GO:0007099)2.14259528
167positive regulation of interferon-alpha production (GO:0032727)2.13639545
168inositol phosphate catabolic process (GO:0071545)2.13245630
169smooth muscle tissue development (GO:0048745)2.12920212
170Golgi organization (GO:0007030)2.12868730
171ER to Golgi vesicle-mediated transport (GO:0006888)2.12312849
172regulation of transforming growth factor beta2 production (GO:0032909)2.09050383
173production of molecular mediator involved in inflammatory response (GO:0002532)2.08926568
174regulation of germinal center formation (GO:0002634)2.08485246
175regulation of B cell receptor signaling pathway (GO:0050855)2.06749563
176cell morphogenesis involved in neuron differentiation (GO:0048667)2.06320586
177regulation of interferon-alpha production (GO:0032647)2.05341099
178protein O-linked glycosylation (GO:0006493)2.04950927
179cellular response to antibiotic (GO:0071236)2.03685260
180regulation of heart rate by cardiac conduction (GO:0086091)2.03539457
181positive regulation of toll-like receptor signaling pathway (GO:0034123)2.01828702
182protein K48-linked deubiquitination (GO:0071108)2.00906818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.71187797
2EZH2_22144423_ChIP-Seq_EOC_Human3.47945547
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.35286814
4GBX2_23144817_ChIP-Seq_PC3_Human3.16830527
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.11739371
6TAF15_26573619_Chip-Seq_HEK293_Human2.94885552
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.84276143
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.78945034
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.69715346
10* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.59071897
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.36562235
12CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33398669
13BMI1_23680149_ChIP-Seq_NPCS_Mouse2.21722826
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.12105300
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.10763331
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.09241703
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06142389
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00661452
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.98749778
20VDR_22108803_ChIP-Seq_LS180_Human1.97418170
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.96869992
22SMAD_19615063_ChIP-ChIP_OVARY_Human1.96401169
23P300_19829295_ChIP-Seq_ESCs_Human1.94094497
24NANOG_18555785_Chip-Seq_ESCs_Mouse1.93224109
25NFE2_27457419_Chip-Seq_LIVER_Mouse1.91426259
26TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.89590578
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.86543462
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.84296092
29EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.82361708
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80754963
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77968020
32FUS_26573619_Chip-Seq_HEK293_Human1.77881242
33RNF2_27304074_Chip-Seq_NSC_Mouse1.76879637
34P53_22387025_ChIP-Seq_ESCs_Mouse1.76591775
35SMAD4_21799915_ChIP-Seq_A2780_Human1.75474787
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.73998754
37ZNF274_21170338_ChIP-Seq_K562_Hela1.73964373
38ER_23166858_ChIP-Seq_MCF-7_Human1.73750454
39AR_21572438_ChIP-Seq_LNCaP_Human1.72996038
40TP53_16413492_ChIP-PET_HCT116_Human1.72797892
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.72393528
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72136614
43SUZ12_18555785_Chip-Seq_ESCs_Mouse1.70893737
44E2F1_18555785_Chip-Seq_ESCs_Mouse1.69757367
45FOXM1_26456572_ChIP-Seq_MCF-7_Human1.66960443
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66477491
47ESR1_20079471_ChIP-ChIP_T-47D_Human1.65841865
48P300_18555785_Chip-Seq_ESCs_Mouse1.65839034
49STAT3_18555785_Chip-Seq_ESCs_Mouse1.64277590
50CMYC_18555785_Chip-Seq_ESCs_Mouse1.62491209
51IGF1R_20145208_ChIP-Seq_DFB_Human1.62434472
52EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.62049674
53AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.55360740
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.54675478
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.54626728
56NMYC_18555785_Chip-Seq_ESCs_Mouse1.54191475
57SMAD3_21741376_ChIP-Seq_EPCs_Human1.53752943
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.52026209
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.52026209
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.51294335
61Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.51063043
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.50785630
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50447513
64FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50321876
65CDX2_22108803_ChIP-Seq_LS180_Human1.49811463
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.49286804
67SOX2_18555785_Chip-Seq_ESCs_Mouse1.48902565
68AHR_22903824_ChIP-Seq_MCF-7_Human1.46718604
69KDM2B_26808549_Chip-Seq_REH_Human1.45703633
70SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44528512
71SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44345441
72OCT4_18555785_Chip-Seq_ESCs_Mouse1.44251822
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42769195
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42376215
75CJUN_26792858_Chip-Seq_BT549_Human1.42202528
76BRD4_25478319_ChIP-Seq_HGPS_Human1.42056400
77RUNX1_27457419_Chip-Seq_LIVER_Mouse1.40557385
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.39914339
79EED_16625203_ChIP-ChIP_MESCs_Mouse1.38996506
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37881800
81TP53_18474530_ChIP-ChIP_U2OS_Human1.36414242
82CRX_20693478_ChIP-Seq_RETINA_Mouse1.35709303
83SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.35605955
84TP63_23658742_ChIP-Seq_EP156T_Human1.34171201
85SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.33785587
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.33534183
87ZFX_18555785_Chip-Seq_ESCs_Mouse1.33283854
88WT1_19549856_ChIP-ChIP_CCG9911_Human1.32927933
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31830589
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31543841
91CBP_20019798_ChIP-Seq_JUKART_Human1.31543841
92KLF4_18555785_Chip-Seq_ESCs_Mouse1.31488783
93RUNX_20019798_ChIP-Seq_JUKART_Human1.31437360
94PU1_27457419_Chip-Seq_LIVER_Mouse1.31120343
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.30008343
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.28745944
97RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27978175
98ESRRB_18555785_Chip-Seq_ESCs_Mouse1.26592179
99CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25985989
100SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25964544
101CTCF_18555785_Chip-Seq_ESCs_Mouse1.25265031
102SMAD1_18555785_Chip-Seq_ESCs_Mouse1.25151296
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.25068513
104STAT3_23295773_ChIP-Seq_U87_Human1.23298774
105OCT4_21477851_ChIP-Seq_ESCs_Mouse1.22673356
106NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21517905
107AR_25329375_ChIP-Seq_VCAP_Human1.21373662
108RUNX2_22187159_ChIP-Seq_PCA_Human1.20626734
109BCAT_22108803_ChIP-Seq_LS180_Human1.20397630
110SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20176065
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.20133890
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.19342983
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.18404452
114* JUN_21703547_ChIP-Seq_K562_Human1.17901180
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17652607
116TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17652607
117TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.16848062
118TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16600577
119TCF4_23295773_ChIP-Seq_U87_Human1.16511285
120EWS_26573619_Chip-Seq_HEK293_Human1.16025164
121CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15962988
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15716832
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.15025149
124PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14415921
125ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.13635328
126FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.13332029
127PRDM14_20953172_ChIP-Seq_ESCs_Human1.13226760
128ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12760565
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.12488398
130TCF4_22108803_ChIP-Seq_LS180_Human1.12277938
131FOXO3_23340844_ChIP-Seq_DLD1_Human1.12246221
132RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09805925
133EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09805925
134VDR_24787735_ChIP-Seq_THP-1_Human1.07981184
135GATA1_22025678_ChIP-Seq_K562_Human1.04297222
136TCF4_18268006_ChIP-ChIP_LS174T_Human1.04275794
137SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02598591
138FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98684816
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98287742
140SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.97128176
141IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96865193

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.17434686
2MP0000372_irregular_coat_pigmentation3.95488994
3MP0005171_absent_coat_pigmentation3.63518220
4MP0001188_hyperpigmentation3.36939796
5MP0002102_abnormal_ear_morphology3.33650755
6MP0008057_abnormal_DNA_replication3.04270875
7MP0005410_abnormal_fertilization2.98680068
8MP0001986_abnormal_taste_sensitivity2.88285281
9MP0005409_darkened_coat_color2.81889674
10MP0004381_abnormal_hair_follicle2.58030755
11MP0006276_abnormal_autonomic_nervous2.56412692
12MP0000015_abnormal_ear_pigmentation2.41183513
13MP0003195_calcinosis2.20342743
14MP0002166_altered_tumor_susceptibility2.16441074
15MP0002735_abnormal_chemical_nociception2.11793398
16MP0002009_preneoplasia2.07132305
17MP0009379_abnormal_foot_pigmentation2.04312324
18MP0003880_abnormal_central_pattern2.03581106
19MP0003724_increased_susceptibility_to2.01341256
20MP0006292_abnormal_olfactory_placode1.95955610
21MP0006054_spinal_hemorrhage1.89585942
22MP0000427_abnormal_hair_cycle1.85330957
23MP0002876_abnormal_thyroid_physiology1.82387472
24MP0010352_gastrointestinal_tract_polyps1.80327530
25MP0000566_synostosis1.74757084
26MP0003656_abnormal_erythrocyte_physiolo1.74456885
27MP0004215_abnormal_myocardial_fiber1.71217944
28MP0004742_abnormal_vestibular_system1.71118271
29MP0009250_abnormal_appendicular_skeleto1.70304062
30MP0004270_analgesia1.68853291
31MP0008004_abnormal_stomach_pH1.67728221
32MP0000371_diluted_coat_color1.65022938
33MP0002282_abnormal_trachea_morphology1.63437687
34MP0009046_muscle_twitch1.57770417
35MP0005408_hypopigmentation1.56018457
36MP0000013_abnormal_adipose_tissue1.55412209
37MP0003828_pulmonary_edema1.52970030
38MP0003763_abnormal_thymus_physiology1.52951326
39MP0001968_abnormal_touch/_nociception1.52008544
40MP0002928_abnormal_bile_duct1.51744679
41MP0003787_abnormal_imprinting1.48066014
42MP0002163_abnormal_gland_morphology1.46379955
43MP0000026_abnormal_inner_ear1.44072504
44MP0004134_abnormal_chest_morphology1.42694645
45MP0005379_endocrine/exocrine_gland_phen1.42433243
46MP0002277_abnormal_respiratory_mucosa1.41103870
47MP0008877_abnormal_DNA_methylation1.40566493
48MP0002734_abnormal_mechanical_nocicepti1.38264346
49MP0005164_abnormal_response_to1.38240005
50MP0001963_abnormal_hearing_physiology1.34940079
51MP0002638_abnormal_pupillary_reflex1.34779904
52MP0005646_abnormal_pituitary_gland1.33500140
53MP0001765_abnormal_ion_homeostasis1.33474995
54MP0003183_abnormal_peptide_metabolism1.30999512
55MP0002006_tumorigenesis1.30565433
56MP0004484_altered_response_of1.29831562
57MP0003950_abnormal_plasma_membrane1.29476307
58MP0005075_abnormal_melanosome_morpholog1.29346871
59MP0010678_abnormal_skin_adnexa1.28787944
60MP0002132_abnormal_respiratory_system1.28509824
61MP0001835_abnormal_antigen_presentation1.28369136
62MP0003252_abnormal_bile_duct1.27161146
63MP0002177_abnormal_outer_ear1.23204796
64MP0002877_abnormal_melanocyte_morpholog1.22651577
65MP0005257_abnormal_intraocular_pressure1.22626123
66MP0005503_abnormal_tendon_morphology1.22494417
67MP0003868_abnormal_feces_composition1.21181840
68MP0003045_fibrosis1.20633430
69MP0001905_abnormal_dopamine_level1.19421134
70MP0003937_abnormal_limbs/digits/tail_de1.19301183
71MP0003091_abnormal_cell_migration1.18863219
72MP0002168_other_aberrant_phenotype1.18134509
73MP0001542_abnormal_bone_strength1.16924931
74MP0002751_abnormal_autonomic_nervous1.16587814
75MP0003315_abnormal_perineum_morphology1.16192255
76MP0002095_abnormal_skin_pigmentation1.14446507
77MP0002067_abnormal_sensory_capabilities1.12364150
78MP0000778_abnormal_nervous_system1.12117216
79MP0001485_abnormal_pinna_reflex1.11312857
80MP0002933_joint_inflammation1.11244979
81* MP0003698_abnormal_male_reproductive1.11085651
82MP0009697_abnormal_copulation1.08892589
83MP0000383_abnormal_hair_follicle1.05541091
84MP0000685_abnormal_immune_system1.04863744
85MP0003938_abnormal_ear_development1.04344797
86MP0005174_abnormal_tail_pigmentation1.02975219
87MP0002736_abnormal_nociception_after1.02921250
88MP0004043_abnormal_pH_regulation1.02850762
89MP0010386_abnormal_urinary_bladder1.01429452
90MP0010234_abnormal_vibrissa_follicle1.00545936
91MP0001299_abnormal_eye_distance/1.00493247
92MP0001984_abnormal_olfaction1.00337911
93MP0000049_abnormal_middle_ear0.99216165
94MP0001486_abnormal_startle_reflex0.98890218
95MP0005623_abnormal_meninges_morphology0.98857000
96MP0002653_abnormal_ependyma_morphology0.98197700
97MP0001790_abnormal_immune_system0.97283811
98MP0005387_immune_system_phenotype0.97283811
99MP0003172_abnormal_lysosome_physiology0.96739818
100MP0002938_white_spotting0.96431313
101MP0002272_abnormal_nervous_system0.92664422
102MP0004084_abnormal_cardiac_muscle0.91604948
103MP0001800_abnormal_humoral_immune0.91203820
104MP0002572_abnormal_emotion/affect_behav0.90250250
105MP0004883_abnormal_blood_vessel0.89517102
106MP0001879_abnormal_lymphatic_vessel0.88839947
107MP0003300_gastrointestinal_ulcer0.88801082
108MP0005310_abnormal_salivary_gland0.88122099
109MP0002332_abnormal_exercise_endurance0.88078701
110MP0005275_abnormal_skin_tensile0.87916659
111MP0005645_abnormal_hypothalamus_physiol0.86288030
112MP0009785_altered_susceptibility_to0.85148233
113MP0008438_abnormal_cutaneous_collagen0.84978248
114MP0001177_atelectasis0.84697747
115MP0001944_abnormal_pancreas_morphology0.82598505
116MP0002557_abnormal_social/conspecific_i0.82371350
117MP0009745_abnormal_behavioral_response0.82336416
118MP0005377_hearing/vestibular/ear_phenot0.82213330
119MP0003878_abnormal_ear_physiology0.82213330
120* MP0001929_abnormal_gametogenesis0.81865693
121MP0003755_abnormal_palate_morphology0.81321497
122MP0000631_abnormal_neuroendocrine_gland0.81178193
123MP0006072_abnormal_retinal_apoptosis0.80358302
124MP0001324_abnormal_eye_pigmentation0.79501521
125MP0005084_abnormal_gallbladder_morpholo0.78971313
126MP0004782_abnormal_surfactant_physiolog0.78252573
127MP0002184_abnormal_innervation0.78090565
128MP0010155_abnormal_intestine_physiology0.77433661
129MP0001663_abnormal_digestive_system0.77094869
130MP0001502_abnormal_circadian_rhythm0.76731308
131MP0001270_distended_abdomen0.76237994
132MP0000569_abnormal_digit_pigmentation0.75926342
133MP0001970_abnormal_pain_threshold0.75573935
134MP0009780_abnormal_chondrocyte_physiolo0.75019342
135MP0002229_neurodegeneration0.73923252
136MP0005253_abnormal_eye_physiology0.73668353
137MP0004272_abnormal_basement_membrane0.73020674
138MP0003385_abnormal_body_wall0.72070129
139MP0005551_abnormal_eye_electrophysiolog0.71346970
140MP0001851_eye_inflammation0.70102952
141MP0002452_abnormal_antigen_presenting0.69661957
142MP0003221_abnormal_cardiomyocyte_apopto0.69660149
143MP0003122_maternal_imprinting0.69580969
144MP0004264_abnormal_extraembryonic_tissu0.69389251
145MP0000762_abnormal_tongue_morphology0.69281065
146MP0002752_abnormal_somatic_nervous0.68848897
147MP0003633_abnormal_nervous_system0.68130998
148MP0004142_abnormal_muscle_tone0.67745684
149MP0002396_abnormal_hematopoietic_system0.67225421
150MP0001346_abnormal_lacrimal_gland0.66765373
151MP0001664_abnormal_digestion0.66503525
152* MP0002210_abnormal_sex_determination0.66338767
153MP0005248_abnormal_Harderian_gland0.66217300
154MP0002133_abnormal_respiratory_system0.66213981
155MP0005388_respiratory_system_phenotype0.66213981
156MP0002136_abnormal_kidney_physiology0.66161798
157MP0005636_abnormal_mineral_homeostasis0.65772046
158MP0000465_gastrointestinal_hemorrhage0.65141353
159MP0001501_abnormal_sleep_pattern0.64545255
160MP0002723_abnormal_immune_serum0.64384559
161MP0002295_abnormal_pulmonary_circulatio0.64102419
162MP0002405_respiratory_system_inflammati0.62080400
163MP0005376_homeostasis/metabolism_phenot0.60422813
164MP0001873_stomach_inflammation0.59300298
165MP0005187_abnormal_penis_morphology0.58268563
166MP0005464_abnormal_platelet_physiology0.57644100
167MP0001845_abnormal_inflammatory_respons0.56110217
168MP0000613_abnormal_salivary_gland0.53912778
169MP0002998_abnormal_bone_remodeling0.53350972
170MP0008775_abnormal_heart_ventricle0.53260854
171MP0000249_abnormal_blood_vessel0.52436167

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.56999754
2Abnormal ciliary motility (HP:0012262)6.64207184
3Abnormal respiratory motile cilium physiology (HP:0012261)6.50208511
4Dynein arm defect of respiratory motile cilia (HP:0012255)6.25570707
5Absent/shortened dynein arms (HP:0200106)6.25570707
6Abnormal respiratory epithelium morphology (HP:0012253)5.32380829
7Abnormal respiratory motile cilium morphology (HP:0005938)5.32380829
8Rhinitis (HP:0012384)5.10395950
9Ventricular fibrillation (HP:0001663)4.47191734
10Degeneration of the lateral corticospinal tracts (HP:0002314)3.70710482
11Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.70710482
12Termporal pattern (HP:0011008)3.56280361
13Insidious onset (HP:0003587)3.56280361
14Hypothermia (HP:0002045)3.53881598
15Fair hair (HP:0002286)3.50602195
16Medial flaring of the eyebrow (HP:0010747)3.38355723
17Papillary thyroid carcinoma (HP:0002895)3.31946271
18Generalized hypopigmentation of hair (HP:0011358)3.13523289
19Hypoplastic labia majora (HP:0000059)3.08550864
20Chronic bronchitis (HP:0004469)3.07731795
21Abnormality of the renal cortex (HP:0011035)3.05226799
22Abnormality of incisor morphology (HP:0011063)3.03799516
23Fibular hypoplasia (HP:0003038)3.00152813
24Bronchiectasis (HP:0002110)2.99712871
25Submucous cleft hard palate (HP:0000176)2.99334546
26True hermaphroditism (HP:0010459)2.98461788
27Hyperventilation (HP:0002883)2.95060265
28Nephronophthisis (HP:0000090)2.93418809
29Chronic hepatic failure (HP:0100626)2.82478692
30T lymphocytopenia (HP:0005403)2.78211674
31Abnormality of the labia majora (HP:0012881)2.74956187
32Volvulus (HP:0002580)2.73427490
33Prolonged QT interval (HP:0001657)2.73113415
34Pancreatic fibrosis (HP:0100732)2.68518217
35Abnormality of T cell number (HP:0011839)2.67628543
36Abnormality of the corticospinal tract (HP:0002492)2.67423451
37Short tibia (HP:0005736)2.64998125
38Gait imbalance (HP:0002141)2.64357354
39Thyroiditis (HP:0100646)2.64259828
40Syncope (HP:0001279)2.63479098
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.61334028
42Albinism (HP:0001022)2.59040760
43Median cleft lip (HP:0000161)2.58603733
44Widely spaced teeth (HP:0000687)2.58595261
45Congenital primary aphakia (HP:0007707)2.57601528
46Abnormal hair whorl (HP:0010721)2.56097793
47Irregular epiphyses (HP:0010582)2.51046068
48Renal cortical cysts (HP:0000803)2.50906385
49Curly hair (HP:0002212)2.46901721
50Abnormality of the renal medulla (HP:0100957)2.45768045
51Aplasia/Hypoplasia of the fovea (HP:0008060)2.45308173
52Hypoplasia of the fovea (HP:0007750)2.45308173
53Thyroid carcinoma (HP:0002890)2.43281598
54Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.39929443
55Nephrogenic diabetes insipidus (HP:0009806)2.39293844
56Recurrent sinusitis (HP:0011108)2.37440202
57Tubular atrophy (HP:0000092)2.36943199
58Febrile seizures (HP:0002373)2.31338761
59Abnormal sex determination (HP:0012244)2.29382915
60Sex reversal (HP:0012245)2.29382915
61Tubulointerstitial nephritis (HP:0001970)2.25273285
62Epiphyseal dysplasia (HP:0002656)2.24527836
63Absent speech (HP:0001344)2.24234619
64Recurrent bronchitis (HP:0002837)2.23600216
65Abnormality of the ischium (HP:0003174)2.22329721
66Abnormality of midbrain morphology (HP:0002418)2.20260199
67Molar tooth sign on MRI (HP:0002419)2.20260199
68Abnormal biliary tract morphology (HP:0012440)2.19163822
69Atelectasis (HP:0100750)2.19002085
70Neoplasm of the tracheobronchial system (HP:0100552)2.14900034
71Biliary tract neoplasm (HP:0100574)2.13890501
72Genital tract atresia (HP:0001827)2.13553229
73Infertility (HP:0000789)2.11307260
74Aplasia/Hypoplasia of the lens (HP:0008063)2.10501112
75Vitreoretinal degeneration (HP:0000655)2.09464645
76Hyperkalemia (HP:0002153)2.08109600
77Hematochezia (HP:0002573)2.06922653
78Spondylolisthesis (HP:0003302)2.06160026
79Global brain atrophy (HP:0002283)2.06092022
80Aplasia/Hypoplasia of the fibula (HP:0006492)2.05780287
81Blue irides (HP:0000635)2.04682013
82Decreased central vision (HP:0007663)2.04233483
83Decreased circulating renin level (HP:0003351)2.03182847
84Hypoproteinemia (HP:0003075)2.02048146
85Focal motor seizures (HP:0011153)2.01884003
86Vaginal atresia (HP:0000148)2.00724706
87Thoracolumbar scoliosis (HP:0002944)1.99202019
88Atonic seizures (HP:0010819)1.95870037
89Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.95120516
90Nasal polyposis (HP:0100582)1.95067839
91Abnormality of the nasal septum (HP:0000419)1.94877506
92Aplasia/Hypoplasia of the macula (HP:0008059)1.94774941
93Poor coordination (HP:0002370)1.94571470
94Hip dysplasia (HP:0001385)1.94369930
95Agammaglobulinemia (HP:0004432)1.94134408
96Alveolar cell carcinoma (HP:0006519)1.93526867
97Papilledema (HP:0001085)1.93174030
98Optic disc pallor (HP:0000543)1.92901230
99Abnormality of the fovea (HP:0000493)1.92055803
100Male pseudohermaphroditism (HP:0000037)1.90823556
101Chronic diarrhea (HP:0002028)1.89433726
102Bronchitis (HP:0012387)1.88005858
103Asthma (HP:0002099)1.87620816
104Menstrual irregularities (HP:0000858)1.87083208
105Pancreatic cysts (HP:0001737)1.85651341
106Esotropia (HP:0000565)1.84741459
107Congenital sensorineural hearing impairment (HP:0008527)1.84454227
108Gaze-evoked nystagmus (HP:0000640)1.84049292
109Abnormality of B cell number (HP:0010975)1.83803342
110Follicular hyperkeratosis (HP:0007502)1.81707072
111Upper limb muscle weakness (HP:0003484)1.80471416
112Autoimmune hemolytic anemia (HP:0001890)1.80431210
113Arthropathy (HP:0003040)1.80384861
114Hypoplastic ischia (HP:0003175)1.80235222
115Ulnar claw (HP:0001178)1.79956923
116Mitral stenosis (HP:0001718)1.79303632
117Postaxial foot polydactyly (HP:0001830)1.79248012
118Absent frontal sinuses (HP:0002688)1.78464976
119B lymphocytopenia (HP:0010976)1.78449220
120Flat capital femoral epiphysis (HP:0003370)1.78262176
121Aplasia/Hypoplasia of the tongue (HP:0010295)1.78082244
122Aortic dissection (HP:0002647)1.77814311
123Attenuation of retinal blood vessels (HP:0007843)1.76547476
124Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.75293860
125Abnormal pancreas size (HP:0012094)1.75154949
126Abnormality of the frontal sinuses (HP:0002687)1.74657439
127Truncal obesity (HP:0001956)1.74292201
128Eosinophilia (HP:0001880)1.73147265
129Neonatal short-limb short stature (HP:0008921)1.72996453
130Prostate neoplasm (HP:0100787)1.72818292
131Cone-rod dystrophy (HP:0000548)1.71322587
132Adrenal hypoplasia (HP:0000835)1.69802469
133Preaxial hand polydactyly (HP:0001177)1.68979351
134Abnormal EKG (HP:0003115)1.68383039
135Labial hypoplasia (HP:0000066)1.67813620
136Cutaneous melanoma (HP:0012056)1.67758694
137Exocrine pancreatic insufficiency (HP:0001738)1.67426298
138Renal dysplasia (HP:0000110)1.67063085
139Congenital hepatic fibrosis (HP:0002612)1.66430440
140Postaxial hand polydactyly (HP:0001162)1.66037205
141Patchy hypopigmentation of hair (HP:0011365)1.65225841
142Abnormality of the axillary hair (HP:0100134)1.62576275
143Abnormality of secondary sexual hair (HP:0009888)1.62576275
144Protruding tongue (HP:0010808)1.62463383
145Stage 5 chronic kidney disease (HP:0003774)1.62092347
146Hypoplasia of the thymus (HP:0000778)1.61555459
147Abnormality of the fibula (HP:0002991)1.60806675
148Small epiphyses (HP:0010585)1.60762066
149Furrowed tongue (HP:0000221)1.60681068
150Hyperthyroidism (HP:0000836)1.60290455
151Cupped ribs (HP:0000887)1.59096568
152Nonprogressive disorder (HP:0003680)1.58836877
153Thickened calvaria (HP:0002684)1.58295084
154Arterial tortuosity (HP:0005116)1.57033893
155Aplasia/Hypoplasia affecting the retina (HP:0008061)1.56686652
156Chronic sinusitis (HP:0011109)1.56235986
157Metaphyseal dysplasia (HP:0100255)1.55800014
158Polydipsia (HP:0001959)1.55602771
159Abnormal drinking behavior (HP:0030082)1.55602771
160White forelock (HP:0002211)1.53632467
161Tracheomalacia (HP:0002779)1.53463149
162Short femoral neck (HP:0100864)1.53258524
163Keratoconus (HP:0000563)1.52805189
164Increased corneal curvature (HP:0100692)1.52805189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.37555511
2MKNK24.36616624
3ACVR1B2.45231515
4MKNK12.32573255
5PRPF4B2.32421705
6PINK12.23772545
7MST42.00325944
8LATS11.88690800
9BMPR1B1.87152467
10MAP3K141.85945150
11MUSK1.83250164
12MAPK151.72090397
13TNIK1.60530135
14STK391.59619227
15YES11.57395936
16BCR1.55174284
17TLK11.53965469
18BRD41.52217819
19MAP2K71.51243290
20NEK61.45430296
21IRAK11.41297748
22JAK11.38459901
23FRK1.35105529
24PIK3CA1.33608507
25ADRBK21.33291243
26STK31.33285186
27FGFR31.32524015
28PAK31.32473766
29MAPK131.26874344
30TGFBR11.25347455
31BMPR21.25258919
32SGK21.24353963
33LIMK11.23464176
34PLK21.23377655
35GRK71.22046417
36TRIM281.21494206
37BRSK21.19492286
38PDK21.17595465
39IRAK31.14390925
40AKT31.12833067
41BLK1.12643643
42IRAK41.12517139
43MAP3K121.11807816
44EPHA31.11482940
45ZAK1.11401751
46STK241.11281689
47BRAF1.11044478
48STK161.10369590
49TXK1.08911101
50IRAK21.08769441
51STK381.08325802
52NLK1.04336168
53PNCK1.02858521
54CAMK1G1.02200151
55NUAK11.02059685
56STK38L1.00045735
57PIM20.98133738
58PTK2B0.96329946
59PBK0.93959400
60MAP3K20.93648374
61SGK2230.92838772
62SGK4940.92838772
63CDK30.92389796
64PDK40.92360280
65PDK30.92360280
66WNK40.88643696
67MST1R0.85729449
68PRKCE0.85538182
69INSRR0.85300030
70DYRK20.84116473
71SRPK10.83870409
72TYK20.83248046
73TNK20.81837308
74OXSR10.81326417
75MYLK0.81320644
76ERBB30.81180230
77MAP4K20.79062799
78VRK10.78626586
79FLT30.75252961
80TRPM70.74932945
81SIK30.74206234
82EIF2AK20.71969138
83DYRK1A0.71626932
84PKN10.71262358
85FES0.71076907
86FER0.69936728
87TIE10.68255015
88ERBB40.67757465
89TEC0.65342965
90GRK10.65057241
91CHUK0.64991490
92JAK30.61319166
93BTK0.60852115
94PDGFRB0.60059251
95CAMK1D0.59874818
96NEK90.59268080
97IKBKB0.59199151
98WNK30.58617589
99KIT0.58283110
100EIF2AK30.56736060
101ARAF0.56424653
102TAOK30.55634059
103RPS6KA50.53589709
104CAMK2A0.53291748
105ITK0.53267869
106ROCK10.51934373
107CSK0.51553973
108WNK10.49618566
109EPHB10.49100932
110RPS6KA20.49001891
111GSK3A0.48908879
112MELK0.48638348
113PRKCQ0.47395011
114CAMK2B0.47360666
115STK100.47284374
116EGFR0.46985045
117HCK0.46865493
118CSNK1G10.46846859
119PIK3CG0.46683689
120MARK30.46614979
121ADRBK10.45006773
122WEE10.42655186
123MAPK70.42621204
124FGFR20.42588809
125RPS6KB10.42047346
126ABL10.41870564
127CAMK2D0.41674997
128PRKG20.41363455
129TGFBR20.41342317
130ZAP700.40990613
131PRKG10.40521636
132MAP3K40.40183188
133SGK30.39197058
134MAPKAPK30.39154198
135MET0.37564006
136CAMKK20.37306606
137IKBKE0.37238434
138PRKAA20.36898087
139OBSCN0.36347562
140CSNK1A1L0.35723100
141TESK10.34643221
142PLK30.34635251
143NTRK30.34472328
144RPS6KC10.33653197
145JAK20.32520887
146IGF1R0.32190520
147MAP3K50.32106749
148KSR10.29751123

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.79141626
2Phototransduction_Homo sapiens_hsa047442.20287702
3Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.99295635
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.95387506
5Oxidative phosphorylation_Homo sapiens_hsa001901.86156071
6Nicotine addiction_Homo sapiens_hsa050331.85834748
7Sphingolipid metabolism_Homo sapiens_hsa006001.84492066
8Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.81616116
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.73911180
10Taste transduction_Homo sapiens_hsa047421.71462190
11Autoimmune thyroid disease_Homo sapiens_hsa053201.70745309
12Basal transcription factors_Homo sapiens_hsa030221.69977511
13Rheumatoid arthritis_Homo sapiens_hsa053231.66164206
14Ether lipid metabolism_Homo sapiens_hsa005651.66023394
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.57122002
16Allograft rejection_Homo sapiens_hsa053301.53839378
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.49075524
18Phagosome_Homo sapiens_hsa041451.48366007
19Graft-versus-host disease_Homo sapiens_hsa053321.47050669
20Huntingtons disease_Homo sapiens_hsa050161.45408389
21Malaria_Homo sapiens_hsa051441.39772910
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.39319586
23Sulfur metabolism_Homo sapiens_hsa009201.32200675
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.29929397
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.26710184
26Alzheimers disease_Homo sapiens_hsa050101.26705248
27Collecting duct acid secretion_Homo sapiens_hsa049661.25420608
28Serotonergic synapse_Homo sapiens_hsa047261.23807221
29FoxO signaling pathway_Homo sapiens_hsa040681.23729132
30Butanoate metabolism_Homo sapiens_hsa006501.19318233
31Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18374756
32Legionellosis_Homo sapiens_hsa051341.17574583
33Axon guidance_Homo sapiens_hsa043601.14236307
34Arachidonic acid metabolism_Homo sapiens_hsa005901.13497228
35Vibrio cholerae infection_Homo sapiens_hsa051101.13439714
36Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.10146653
37ABC transporters_Homo sapiens_hsa020101.09018579
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.06623720
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.06043704
40TNF signaling pathway_Homo sapiens_hsa046681.05843842
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.05249968
42Fanconi anemia pathway_Homo sapiens_hsa034601.05220228
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04338704
44Other glycan degradation_Homo sapiens_hsa005111.03294840
45Melanoma_Homo sapiens_hsa052181.02987032
46Regulation of autophagy_Homo sapiens_hsa041401.02056185
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01690936
48Maturity onset diabetes of the young_Homo sapiens_hsa049501.00580645
49Inositol phosphate metabolism_Homo sapiens_hsa005621.00032005
50Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99288265
51Amphetamine addiction_Homo sapiens_hsa050310.99092579
52TGF-beta signaling pathway_Homo sapiens_hsa043500.98504640
53Platelet activation_Homo sapiens_hsa046110.97905532
54Hematopoietic cell lineage_Homo sapiens_hsa046400.96075319
55B cell receptor signaling pathway_Homo sapiens_hsa046620.95598189
56Renal cell carcinoma_Homo sapiens_hsa052110.95189581
57Type I diabetes mellitus_Homo sapiens_hsa049400.94854401
58Olfactory transduction_Homo sapiens_hsa047400.94440888
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93437723
60Asthma_Homo sapiens_hsa053100.92218093
61Hepatitis B_Homo sapiens_hsa051610.91533140
62Fatty acid elongation_Homo sapiens_hsa000620.89358885
63Nitrogen metabolism_Homo sapiens_hsa009100.89064820
64Parkinsons disease_Homo sapiens_hsa050120.88668874
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.84595308
66Prostate cancer_Homo sapiens_hsa052150.83914541
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83468817
68Morphine addiction_Homo sapiens_hsa050320.82705265
69Steroid biosynthesis_Homo sapiens_hsa001000.82700605
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82234115
71Prolactin signaling pathway_Homo sapiens_hsa049170.81664925
72Hepatitis C_Homo sapiens_hsa051600.81568872
73Hedgehog signaling pathway_Homo sapiens_hsa043400.81197159
74Long-term depression_Homo sapiens_hsa047300.80651507
75ECM-receptor interaction_Homo sapiens_hsa045120.80611714
76Mineral absorption_Homo sapiens_hsa049780.79580569
77Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78736149
78Insulin secretion_Homo sapiens_hsa049110.78511252
79Non-homologous end-joining_Homo sapiens_hsa034500.78230821
80Selenocompound metabolism_Homo sapiens_hsa004500.77402956
81Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74710989
82Cocaine addiction_Homo sapiens_hsa050300.73014941
83Ras signaling pathway_Homo sapiens_hsa040140.72363046
84Renin secretion_Homo sapiens_hsa049240.72093384
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71914923
86Dorso-ventral axis formation_Homo sapiens_hsa043200.70608408
87Toxoplasmosis_Homo sapiens_hsa051450.69245348
88Measles_Homo sapiens_hsa051620.69200210
89Glutamatergic synapse_Homo sapiens_hsa047240.69161281
90Proteoglycans in cancer_Homo sapiens_hsa052050.68913279
91Focal adhesion_Homo sapiens_hsa045100.68859345
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.68153614
93Osteoclast differentiation_Homo sapiens_hsa043800.67442870
94Linoleic acid metabolism_Homo sapiens_hsa005910.65619460
95Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65027249
96Influenza A_Homo sapiens_hsa051640.64942952
97Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64600444
98Circadian rhythm_Homo sapiens_hsa047100.62974649
99Salmonella infection_Homo sapiens_hsa051320.62665116
100Melanogenesis_Homo sapiens_hsa049160.62659878
101Insulin resistance_Homo sapiens_hsa049310.62232547
102Dopaminergic synapse_Homo sapiens_hsa047280.60711269
103Caffeine metabolism_Homo sapiens_hsa002320.60227840
104African trypanosomiasis_Homo sapiens_hsa051430.60121771
105RNA degradation_Homo sapiens_hsa030180.59679455
106Starch and sucrose metabolism_Homo sapiens_hsa005000.59665647
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59490567
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59340301
109mTOR signaling pathway_Homo sapiens_hsa041500.59212585
110Chemokine signaling pathway_Homo sapiens_hsa040620.58761393
111Estrogen signaling pathway_Homo sapiens_hsa049150.58017005
112Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.57901167
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56980684
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.56739506
115Circadian entrainment_Homo sapiens_hsa047130.56541622
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.56067076
117Chemical carcinogenesis_Homo sapiens_hsa052040.56043732
118Tuberculosis_Homo sapiens_hsa051520.55548499
119Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55356252
120PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54160590
121ErbB signaling pathway_Homo sapiens_hsa040120.53937317
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.52269556
123Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.52179724
124T cell receptor signaling pathway_Homo sapiens_hsa046600.51885688
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51816197
126Protein digestion and absorption_Homo sapiens_hsa049740.51426997
127GABAergic synapse_Homo sapiens_hsa047270.51222159
128p53 signaling pathway_Homo sapiens_hsa041150.50981493
129Systemic lupus erythematosus_Homo sapiens_hsa053220.50468968
130Leukocyte transendothelial migration_Homo sapiens_hsa046700.50231872
131Long-term potentiation_Homo sapiens_hsa047200.50035915
132Calcium signaling pathway_Homo sapiens_hsa040200.49697039
133Primary immunodeficiency_Homo sapiens_hsa053400.49461830
134Pathways in cancer_Homo sapiens_hsa052000.49042504
135cAMP signaling pathway_Homo sapiens_hsa040240.48905956
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48800204
137Pancreatic secretion_Homo sapiens_hsa049720.48738775
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48297456
139Choline metabolism in cancer_Homo sapiens_hsa052310.48251916
140Type II diabetes mellitus_Homo sapiens_hsa049300.48104511
141Endometrial cancer_Homo sapiens_hsa052130.47888868
142Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47824327
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.47320499
144Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47118066
145Alcoholism_Homo sapiens_hsa050340.46805819
146Propanoate metabolism_Homo sapiens_hsa006400.46338285
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45945486
148Wnt signaling pathway_Homo sapiens_hsa043100.45704188
149Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45631669
150MicroRNAs in cancer_Homo sapiens_hsa052060.45529191
151Cholinergic synapse_Homo sapiens_hsa047250.41985192
152MAPK signaling pathway_Homo sapiens_hsa040100.41171309
153RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.40302235
154Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.39356550
155Transcriptional misregulation in cancer_Homo sapiens_hsa052020.38152057
156Ovarian steroidogenesis_Homo sapiens_hsa049130.36694083
157Cardiac muscle contraction_Homo sapiens_hsa042600.36606669

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