TMEM95

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium movement (GO:0003341)9.88691816
2axonemal dynein complex assembly (GO:0070286)8.22327972
3sperm capacitation (GO:0048240)7.44416361
4keratinocyte development (GO:0003334)7.07553504
5sperm motility (GO:0030317)6.77242706
6motile cilium assembly (GO:0044458)6.27157133
7acrosome reaction (GO:0007340)6.03295435
8cilium or flagellum-dependent cell motility (GO:0001539)5.83650027
9epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.70675349
10axoneme assembly (GO:0035082)5.60911228
11cell wall macromolecule catabolic process (GO:0016998)5.39928075
12cell wall macromolecule metabolic process (GO:0044036)5.39928075
13acrosome assembly (GO:0001675)5.39910184
14sperm-egg recognition (GO:0035036)5.29853908
15regulation of cilium movement (GO:0003352)5.27775409
16fusion of sperm to egg plasma membrane (GO:0007342)5.26500439
17binding of sperm to zona pellucida (GO:0007339)4.89655568
18ventricular system development (GO:0021591)4.86348975
19pericardium development (GO:0060039)4.84003072
20modulation by virus of host process (GO:0019054)4.75746430
21phosphorelay signal transduction system (GO:0000160)4.68954966
22cell-cell recognition (GO:0009988)4.65747425
23endothelial tube morphogenesis (GO:0061154)4.58195633
24morphogenesis of an endothelium (GO:0003159)4.58195633
25spermatid development (GO:0007286)4.54254803
26venous blood vessel morphogenesis (GO:0048845)4.53132569
27multicellular organism reproduction (GO:0032504)4.43698499
28xenobiotic catabolic process (GO:0042178)4.35967094
29response to nitrosative stress (GO:0051409)4.14460852
30single fertilization (GO:0007338)3.89364069
31reproduction (GO:0000003)3.86794602
32negative regulation of anoikis (GO:2000811)3.86348644
33regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.81201114
34plasma membrane fusion (GO:0045026)3.80012725
35modulation by symbiont of host cellular process (GO:0044068)3.74458761
36negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.69684685
37microtubule bundle formation (GO:0001578)3.69029243
38regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.68973259
39microtubule depolymerization (GO:0007019)3.67308905
40negative regulation of catenin import into nucleus (GO:0035414)3.66246210
41cellular response to virus (GO:0098586)3.64043648
42spermatogenesis (GO:0007283)3.58365650
43male gamete generation (GO:0048232)3.55741583
44fertilization (GO:0009566)3.53160147
45substrate-dependent cell migration (GO:0006929)3.47898770
46opioid receptor signaling pathway (GO:0038003)3.36746625
47detection of calcium ion (GO:0005513)3.30206715
48cell adhesion mediated by integrin (GO:0033627)3.29016524
49hepatocyte apoptotic process (GO:0097284)3.28235892
50chondrocyte proliferation (GO:0035988)3.27976292
51cilium morphogenesis (GO:0060271)3.27786488
52gamete generation (GO:0007276)3.23946668
53negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)3.17963228
54hypotonic response (GO:0006971)3.13758360
55Rap protein signal transduction (GO:0032486)3.11102734
56organic cation transport (GO:0015695)3.06208007
57cilium organization (GO:0044782)3.03213130
58lactate metabolic process (GO:0006089)3.02483260
59ADP metabolic process (GO:0046031)2.98255189
60intraciliary transport (GO:0042073)2.98214196
61negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97561307
62amyloid precursor protein catabolic process (GO:0042987)2.86558119
63G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.85531873
64nucleoside diphosphate phosphorylation (GO:0006165)2.85515574
65microtubule polymerization or depolymerization (GO:0031109)2.84760681
66retina vasculature morphogenesis in camera-type eye (GO:0061299)2.84749997
67cilium assembly (GO:0042384)2.84679043
68calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.84671998
69cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.80907810
70regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.79522695
71positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.76588385
72regulation of p38MAPK cascade (GO:1900744)2.73310454
73protein polyglutamylation (GO:0018095)2.71910913
74cellular process involved in reproduction in multicellular organism (GO:0022412)2.70346112
75glutathione derivative metabolic process (GO:1901685)2.69301637
76glutathione derivative biosynthetic process (GO:1901687)2.69301637
77planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69279752
78negative regulation of neural precursor cell proliferation (GO:2000178)2.67837995
79regulation of metalloenzyme activity (GO:0048552)2.67783681
80regulation of anoikis (GO:2000209)2.67624374
81negative regulation of inclusion body assembly (GO:0090084)2.66983196
82regulation of G0 to G1 transition (GO:0070316)2.65104713
83positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)2.64658699
84natural killer cell mediated cytotoxicity (GO:0042267)2.61509882
85natural killer cell mediated immunity (GO:0002228)2.61509882
86cellular component assembly involved in morphogenesis (GO:0010927)2.60104137
87metanephric mesenchyme development (GO:0072075)2.57554389
88endothelial cell differentiation (GO:0045446)2.57167412
89microtubule-based movement (GO:0007018)2.56902727
90cell recognition (GO:0008037)2.56107859
91germ cell development (GO:0007281)2.54741737
92membrane assembly (GO:0071709)2.52705978
93protein localization to cilium (GO:0061512)2.51850650
94regulation of microtubule-based movement (GO:0060632)2.51763553
95pattern specification involved in kidney development (GO:0061004)2.50647393
96multicellular organismal reproductive process (GO:0048609)2.50350030
97mesenchymal cell differentiation involved in kidney development (GO:0072161)2.48352333
98mesenchymal cell differentiation involved in renal system development (GO:2001012)2.48352333
99skin morphogenesis (GO:0043589)2.46777596
100epithelial cilium movement (GO:0003351)10.0233380

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.90233174
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.42151979
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.85983873
4PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.79321527
5EZH2_22144423_ChIP-Seq_EOC_Human2.72466979
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61831240
7STAT6_21828071_ChIP-Seq_BEAS2B_Human2.39615771
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.32411222
9TRIM28_21343339_ChIP-Seq_HEK293_Human2.25552424
10* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.21866024
11VDR_22108803_ChIP-Seq_LS180_Human1.77721014
12ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.74786428
13TP53_18474530_ChIP-ChIP_U2OS_Human1.58727035
14CBX2_27304074_Chip-Seq_ESCs_Mouse1.55392179
15PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.52719208
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47523104
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46793193
18ELK4_26923725_Chip-Seq_MESODERM_Mouse1.45251417
19SUZ12_27294783_Chip-Seq_ESCs_Mouse1.42745452
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.41050156
21MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.40028786
22EZH2_27294783_Chip-Seq_ESCs_Mouse1.39138653
23EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38139652
24CJUN_26792858_Chip-Seq_BT549_Human1.36620977
25GBX2_23144817_ChIP-Seq_PC3_Human1.34445028
26GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32839994
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.31253989
28SALL1_21062744_ChIP-ChIP_HESCs_Human1.30120781
29TP63_17297297_ChIP-ChIP_HaCaT_Human1.24131574
30CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23909581
31TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22152576
32SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.20932305
33TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19772851
34NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18412120
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18172855
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.17702706
37* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17440032
38SMAD4_21799915_ChIP-Seq_A2780_Human1.14522388
39DROSHA_22980978_ChIP-Seq_HELA_Human1.13121727
40SMC3_22415368_ChIP-Seq_MEFs_Mouse1.12503344
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.11434564
42AHR_22903824_ChIP-Seq_MCF-7_Human1.11379008
43TAF15_26573619_Chip-Seq_HEK293_Human1.10748563
44ESR1_20079471_ChIP-ChIP_T-47D_Human1.10356636
45HIF1A_21447827_ChIP-Seq_MCF-7_Human1.10299890
46FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.09136152
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07465720
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05971186
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.05971186
50RXR_22108803_ChIP-Seq_LS180_Human1.05870860
51RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02370410
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02138399
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02087959
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01446932
55MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01282685
56GATA1_26923725_Chip-Seq_HPCs_Mouse1.00701777
57CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00188655
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.99719710
59CSB_26484114_Chip-Seq_FIBROBLAST_Human0.97675737
60RNF2_18974828_ChIP-Seq_MESCs_Mouse0.97299834
61EZH2_18974828_ChIP-Seq_MESCs_Mouse0.97299834
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97254735
63ER_23166858_ChIP-Seq_MCF-7_Human0.96661168
64SA1_22415368_ChIP-Seq_MEFs_Mouse0.95919707
65SMAD4_21741376_ChIP-Seq_EPCs_Human0.95542435
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.94874373
67JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94108864
68PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.93418438
69TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92332830
70SMAD3_21741376_ChIP-Seq_EPCs_Human0.91896352
71ARNT_22903824_ChIP-Seq_MCF-7_Human0.90918266
72KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90493184
73RUNX1_27514584_Chip-Seq_MCF-7_Human0.90482872
74SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89228331
75CTCF_27219007_Chip-Seq_Bcells_Human0.88708732
76SMC1_22415368_ChIP-Seq_MEFs_Mouse0.88300672
77BMI1_23680149_ChIP-Seq_NPCS_Mouse0.87800740
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87446510
79JARID2_20075857_ChIP-Seq_MESCs_Mouse0.87441045
80GATA2_21666600_ChIP-Seq_HMVEC_Human0.87365957
81TAL1_26923725_Chip-Seq_HPCs_Mouse0.87211904
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.86642706
83PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86561630
84EZH2_27304074_Chip-Seq_ESCs_Mouse0.85742763
85TBX20_22328084_ChIP-Seq_HEART_Mouse0.85323041
86TBX20_22080862_ChIP-Seq_HEART_Mouse0.85323041
87PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.84024934
88NANOG_18555785_Chip-Seq_ESCs_Mouse0.84010797
89MTF2_20144788_ChIP-Seq_MESCs_Mouse0.83844847
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83562290
91TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.83545541
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82669848
93RNF2_27304074_Chip-Seq_NSC_Mouse0.82660491
94VDR_24787735_ChIP-Seq_THP-1_Human0.82284318
95SMAD3_21741376_ChIP-Seq_ESCs_Human0.82046563
96CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.81727496
97ZNF274_21170338_ChIP-Seq_K562_Hela0.81532436
98FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81242321
99GF1B_26923725_Chip-Seq_HPCs_Mouse0.81015547
100TCF4_22108803_ChIP-Seq_LS180_Human0.80903332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization6.07109644
2MP0005360_urolithiasis5.52920313
3MP0003950_abnormal_plasma_membrane4.90172610
4MP0003191_abnormal_cellular_cholesterol4.79391554
5MP0002653_abnormal_ependyma_morphology4.04148191
6MP0009780_abnormal_chondrocyte_physiolo3.73778126
7MP0003705_abnormal_hypodermis_morpholog3.13039382
8MP0004147_increased_porphyrin_level2.84236932
9MP0005623_abnormal_meninges_morphology2.70270525
10MP0003136_yellow_coat_color2.65500791
11MP0003878_abnormal_ear_physiology2.65322429
12MP0005377_hearing/vestibular/ear_phenot2.65322429
13MP0001984_abnormal_olfaction2.47328852
14MP0003011_delayed_dark_adaptation2.43996884
15MP0004264_abnormal_extraembryonic_tissu2.34884000
16MP0003045_fibrosis2.13116233
17MP0008789_abnormal_olfactory_epithelium2.03982007
18MP0002332_abnormal_exercise_endurance2.01483376
19MP0010352_gastrointestinal_tract_polyps1.99736882
20MP0005670_abnormal_white_adipose1.91106299
21MP0001879_abnormal_lymphatic_vessel1.87045914
22MP0003698_abnormal_male_reproductive1.81016615
23MP0003787_abnormal_imprinting1.79016200
24MP0005499_abnormal_olfactory_system1.78017204
25MP0005394_taste/olfaction_phenotype1.78017204
26MP0002638_abnormal_pupillary_reflex1.73014893
27MP0002282_abnormal_trachea_morphology1.71367391
28MP0003279_aneurysm1.66167840
29MP0009278_abnormal_bone_marrow1.59256128
30MP0008875_abnormal_xenobiotic_pharmacok1.48413917
31MP0005397_hematopoietic_system_phenotyp1.43446641
32MP0001545_abnormal_hematopoietic_system1.43446641
33MP0001929_abnormal_gametogenesis1.43209729
34MP0001958_emphysema1.41596052
35MP0008438_abnormal_cutaneous_collagen1.40884322
36MP0004883_abnormal_blood_vessel1.40000549
37MP0002295_abnormal_pulmonary_circulatio1.37808881
38MP0001542_abnormal_bone_strength1.37324365
39MP0000569_abnormal_digit_pigmentation1.35803053
40MP0003828_pulmonary_edema1.35374970
41MP0005023_abnormal_wound_healing1.27599001
42MP0000015_abnormal_ear_pigmentation1.25014307
43MP0002160_abnormal_reproductive_system1.24618734
44MP0001986_abnormal_taste_sensitivity1.24328993
45MP0005388_respiratory_system_phenotype1.17038616
46MP0002133_abnormal_respiratory_system1.17038616
47MP0001915_intracranial_hemorrhage1.14593802
48MP0009250_abnormal_appendicular_skeleto1.10843679
49MP0000534_abnormal_ureter_morphology1.10469693
50MP0005257_abnormal_intraocular_pressure1.05315570
51MP0002161_abnormal_fertility/fecundity1.03937168
52MP0004233_abnormal_muscle_weight0.97529169
53MP0002234_abnormal_pharynx_morphology0.95873288
54MP0003941_abnormal_skin_development0.95465531
55MP0003385_abnormal_body_wall0.95286807
56MP0002928_abnormal_bile_duct0.92743234
57MP0004272_abnormal_basement_membrane0.92549560
58MP0009840_abnormal_foam_cell0.92527035
59MP0004858_abnormal_nervous_system0.91612211
60MP0000383_abnormal_hair_follicle0.90943782
61MP0003566_abnormal_cell_adhesion0.90626064
62MP0008004_abnormal_stomach_pH0.90451018
63MP0002210_abnormal_sex_determination0.88612088
64MP0006138_congestive_heart_failure0.87060668
65MP0003453_abnormal_keratinocyte_physiol0.80312822
66MP0003755_abnormal_palate_morphology0.79516373
67MP0002168_other_aberrant_phenotype0.79184855
68MP0002938_white_spotting0.77559325
69MP0005595_abnormal_vascular_smooth0.77532881
70MP0001177_atelectasis0.76829185
71MP0002971_abnormal_brown_adipose0.76414810
72MP0005164_abnormal_response_to0.75221951
73MP0003252_abnormal_bile_duct0.74373438
74MP0002098_abnormal_vibrissa_morphology0.73750158
75MP0000163_abnormal_cartilage_morphology0.72658003
76MP0003942_abnormal_urinary_system0.72338130
77MP0002233_abnormal_nose_morphology0.70317329
78MP0003656_abnormal_erythrocyte_physiolo0.68341687
79MP0005551_abnormal_eye_electrophysiolog0.66882693
80MP0000767_abnormal_smooth_muscle0.66413722
81MP0009115_abnormal_fat_cell0.66103040
82MP0004381_abnormal_hair_follicle0.64252486
83MP0010678_abnormal_skin_adnexa0.63602152
84MP0000858_altered_metastatic_potential0.62940497
85MP0001764_abnormal_homeostasis0.62297332
86MP0005389_reproductive_system_phenotype0.62052940
87MP0004134_abnormal_chest_morphology0.61730605
88MP0003091_abnormal_cell_migration0.61596611
89MP0004808_abnormal_hematopoietic_stem0.59650015
90MP0005266_abnormal_metabolism0.59119863
91MP0003186_abnormal_redox_activity0.57477659
92MP0002249_abnormal_larynx_morphology0.57063400
93MP0005275_abnormal_skin_tensile0.54569471
94MP0002115_abnormal_skeleton_extremities0.54480348
95MP0002163_abnormal_gland_morphology0.53093917
96MP0003935_abnormal_craniofacial_develop0.53036524
97MP0002697_abnormal_eye_size0.51736550
98MP0002877_abnormal_melanocyte_morpholog0.50022972
99MP0000432_abnormal_head_morphology0.49958862
100MP0002109_abnormal_limb_morphology0.48499150

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.24285265
2Abnormal respiratory motile cilium physiology (HP:0012261)8.56105951
3Abnormal ciliary motility (HP:0012262)8.09354359
4Abnormal respiratory epithelium morphology (HP:0012253)6.78836470
5Abnormal respiratory motile cilium morphology (HP:0005938)6.78836470
6Rhinitis (HP:0012384)6.73979059
7Absent/shortened dynein arms (HP:0200106)6.64094168
8Dynein arm defect of respiratory motile cilia (HP:0012255)6.64094168
9Chronic bronchitis (HP:0004469)4.73316431
10Tubular atrophy (HP:0000092)3.81967710
11Bronchiectasis (HP:0002110)3.61173904
12True hermaphroditism (HP:0010459)3.59385215
13Nasal polyposis (HP:0100582)3.49388369
14Vascular tortuosity (HP:0004948)3.48582245
15Infertility (HP:0000789)3.40290942
16Fragile skin (HP:0001030)3.26919397
17Pancreatic fibrosis (HP:0100732)3.20386895
18Abnormality of midbrain morphology (HP:0002418)3.10585577
19Molar tooth sign on MRI (HP:0002419)3.10585577
20Abnormality of the nasal mucosa (HP:0000433)3.06906458
21Nephronophthisis (HP:0000090)3.01197785
22Aortic aneurysm (HP:0004942)2.94188151
23Occipital encephalocele (HP:0002085)2.86521222
24Bile duct proliferation (HP:0001408)2.82440741
25Abnormal biliary tract physiology (HP:0012439)2.82440741
26Short nail (HP:0001799)2.81570396
27Cystic liver disease (HP:0006706)2.73852431
28Distal lower limb muscle weakness (HP:0009053)2.71763913
29Flat acetabular roof (HP:0003180)2.71109920
30Epiphyseal dysplasia (HP:0002656)2.59929961
31Bronchitis (HP:0012387)2.53703848
32Sclerocornea (HP:0000647)2.52813123
33Medial flaring of the eyebrow (HP:0010747)2.50609377
34Fibular hypoplasia (HP:0003038)2.49540354
35Asymmetry of the thorax (HP:0001555)2.47995018
36Abnormality of the renal medulla (HP:0100957)2.39788642
37Aplasia/Hypoplasia of the tongue (HP:0010295)2.37903051
38Recurrent sinusitis (HP:0011108)2.36284706
39Abnormality of dentin (HP:0010299)2.35383153
40Abnormality of abdominal situs (HP:0011620)2.30646653
41Abdominal situs inversus (HP:0003363)2.30646653
42Pancreatic cysts (HP:0001737)2.24912412
43Male infertility (HP:0003251)2.19746419
44Chronic hepatic failure (HP:0100626)2.14980455
45Tubulointerstitial nephritis (HP:0001970)2.14499958
46Aplasia/Hypoplasia of the lens (HP:0008063)2.14195697
47Abnormal vertebral ossification (HP:0100569)2.12941608
48Chronic sinusitis (HP:0011109)2.10938542
49Spinal cord compression (HP:0002176)2.08453704
50Recurrent otitis media (HP:0000403)2.03146565
51Osteomalacia (HP:0002749)2.01133317
52Premature rupture of membranes (HP:0001788)2.01038929
53Atelectasis (HP:0100750)1.99213828
54Tubulointerstitial abnormality (HP:0001969)1.95658031
55Absent frontal sinuses (HP:0002688)1.95332170
56Poor coordination (HP:0002370)1.93456330
57Pulmonary artery stenosis (HP:0004415)1.93313700
58Abnormality of carpal bone ossification (HP:0006257)1.92838807
59Tubulointerstitial fibrosis (HP:0005576)1.92760754
60Congenital primary aphakia (HP:0007707)1.92285832
61Gait imbalance (HP:0002141)1.91795575
62Postaxial foot polydactyly (HP:0001830)1.90210304
63Stomach cancer (HP:0012126)1.87072991
64Down-sloping shoulders (HP:0200021)1.84986581
65Short femoral neck (HP:0100864)1.82210903
66Premature skin wrinkling (HP:0100678)1.81134564
67Metaphyseal irregularity (HP:0003025)1.77333635
68Fetal akinesia sequence (HP:0001989)1.75368575
69Obstructive sleep apnea (HP:0002870)1.75140184
70Wormian bones (HP:0002645)1.74432228
71Adrenal hypoplasia (HP:0000835)1.73619131
72Glucose intolerance (HP:0000833)1.72768584
73Vaginal atresia (HP:0000148)1.70926143
74Stage 5 chronic kidney disease (HP:0003774)1.70867439
75Cutaneous melanoma (HP:0012056)1.70808958
76Proximal tubulopathy (HP:0000114)1.70542699
77Abnormality of the distal phalanges of the toes (HP:0010182)1.69430926
78Abnormal ossification of hand bones (HP:0005921)1.68575943
79Xerostomia (HP:0000217)1.68181098
80Cupped ribs (HP:0000887)1.67429168
81Genital tract atresia (HP:0001827)1.65322936
82Scapular winging (HP:0003691)1.62415333
83Bony spicule pigmentary retinopathy (HP:0007737)1.59517125
84Aortic dissection (HP:0002647)1.58989626
85Natal tooth (HP:0000695)1.58905185
86Muscle fiber splitting (HP:0003555)1.58866784
87Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.58687943
88Neonatal short-limb short stature (HP:0008921)1.58660071
89Aplasia/Hypoplasia of the fibula (HP:0006492)1.57082169
90Optic nerve hypoplasia (HP:0000609)1.56359928
91Congenital sensorineural hearing impairment (HP:0008527)1.55446344
92Hypercholesterolemia (HP:0003124)1.54886588
93Aortic valve stenosis (HP:0001650)1.54630936
94Congenital hepatic fibrosis (HP:0002612)1.54171066
95Full cheeks (HP:0000293)1.54094338
9611 pairs of ribs (HP:0000878)1.52642504
97Missing ribs (HP:0000921)1.51577614
98Glossoptosis (HP:0000162)1.50888147
99Delayed epiphyseal ossification (HP:0002663)1.48258217
100Septo-optic dysplasia (HP:0100842)1.48212553

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.90370344
2RIPK14.59499638
3PIM23.45314240
4TESK13.30316521
5TAOK23.29829637
6ARAF3.24098941
7STK38L2.92069020
8EPHA32.86944253
9ADRBK22.61930125
10MAPK152.56984965
11ICK2.56782601
12LATS12.47015609
13PRKD32.33328738
14BRAF2.15041045
15CASK2.06217448
16DYRK1B1.63043879
17STK381.61284989
18EPHA41.59246854
19DDR21.55857556
20STK241.45111057
21PAK31.44980912
22NEK91.37684489
23PDK31.35195317
24PDK41.35195317
25DMPK1.34027033
26BMPR1B1.32355293
27EPHA21.27297975
28STK31.23728824
29PTK2B1.19815993
30MAP3K31.16296953
31STK391.16287278
32PLK31.14604533
33ERBB31.06033013
34HIPK21.02453595
35PRKCH0.99080340
36EPHB20.95284322
37PDK20.94807978
38PRKG20.92395782
39MST40.91106916
40PLK20.90677135
41AKT30.89527091
42EPHB10.89017055
43RPS6KA40.85414691
44FRK0.82886100
45RPS6KA20.74878541
46TTN0.74571758
47PDGFRA0.74460545
48RAF10.70244849
49WNK10.69274305
50FGFR30.65302689
51MAP2K30.64236989
52RPS6KA50.60973670
53TIE10.60965963
54PTK60.59772378
55ZAK0.59251034
56YES10.59078105
57PTK20.58934252
58NEK60.58252623
59NUAK10.57506083
60WNK40.57293169
61CSNK1A1L0.52452536
62TTK0.50986035
63LMTK20.50480141
64IRAK10.49393208
65TRPM70.49046954
66MKNK20.48189812
67CDK60.47994586
68ROCK10.45893463
69RPS6KL10.43549700
70RPS6KC10.43549700
71MAP2K60.40663544
72MAPKAPK20.39997026
73CAMK40.39179491
74INSR0.38696075
75PIM10.37780491
76FGR0.36625578
77ABL10.36451237
78RPS6KA60.35498935
79CSK0.34815661
80PRKG10.34617703
81GSK3A0.33921321
82SGK2230.32478931
83SGK4940.32478931
84FER0.31580624
85PRKCQ0.30984833
86FGFR20.30370759
87ERBB40.28208290
88TEC0.28080522
89SGK20.27627542
90CSNK1G30.27491979
91SRC0.23655124
92TYRO30.22047730
93BCR0.20908150
94VRK10.20341478
95SGK30.19952089
96DYRK30.19674994
97ABL20.19130525
98PHKG20.17838195
99PHKG10.17838195
100PLK10.16913263

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.51853600
2Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009803.42555168
3Drug metabolism - cytochrome P450_Homo sapiens_hsa009823.27743342
4Chemical carcinogenesis_Homo sapiens_hsa052042.98490384
5Olfactory transduction_Homo sapiens_hsa047402.51710779
6Mineral absorption_Homo sapiens_hsa049782.07059879
7Basal cell carcinoma_Homo sapiens_hsa052172.05715940
8Pyruvate metabolism_Homo sapiens_hsa006201.99395457
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.67570971
10Phototransduction_Homo sapiens_hsa047441.67431438
11Focal adhesion_Homo sapiens_hsa045101.62929878
12Glutathione metabolism_Homo sapiens_hsa004801.62134998
13Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.56980481
14Tight junction_Homo sapiens_hsa045301.54757748
15ECM-receptor interaction_Homo sapiens_hsa045121.53128419
16Leukocyte transendothelial migration_Homo sapiens_hsa046701.47270369
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42756160
18Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36572127
19Retinol metabolism_Homo sapiens_hsa008301.34568346
20Hippo signaling pathway_Homo sapiens_hsa043901.32810436
21Circadian entrainment_Homo sapiens_hsa047131.31315168
22Propanoate metabolism_Homo sapiens_hsa006401.26335040
23Endometrial cancer_Homo sapiens_hsa052131.24838050
24Collecting duct acid secretion_Homo sapiens_hsa049661.19929807
25Axon guidance_Homo sapiens_hsa043601.17477367
26Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.13906289
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.11053415
28Adherens junction_Homo sapiens_hsa045201.04253363
29Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.02690951
30Ras signaling pathway_Homo sapiens_hsa040141.00978102
31Proteoglycans in cancer_Homo sapiens_hsa052051.00770457
32Vascular smooth muscle contraction_Homo sapiens_hsa042701.00039722
33Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.98711735
34PI3K-Akt signaling pathway_Homo sapiens_hsa041510.98181282
35Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.97941828
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96396525
37Morphine addiction_Homo sapiens_hsa050320.95739401
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94811132
39Linoleic acid metabolism_Homo sapiens_hsa005910.94178932
40Prostate cancer_Homo sapiens_hsa052150.94105261
41GABAergic synapse_Homo sapiens_hsa047270.91420551
42Renal cell carcinoma_Homo sapiens_hsa052110.88062603
43Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.87809095
44Cholinergic synapse_Homo sapiens_hsa047250.87331115
45Serotonergic synapse_Homo sapiens_hsa047260.86754572
46Pathways in cancer_Homo sapiens_hsa052000.85887529
47Steroid biosynthesis_Homo sapiens_hsa001000.85875563
48Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85321283
49Steroid hormone biosynthesis_Homo sapiens_hsa001400.85190848
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84151890
51Malaria_Homo sapiens_hsa051440.83833798
52Rap1 signaling pathway_Homo sapiens_hsa040150.81928841
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81764086
54Hedgehog signaling pathway_Homo sapiens_hsa043400.80865959
55Salmonella infection_Homo sapiens_hsa051320.77807050
56Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77291148
57Glycerolipid metabolism_Homo sapiens_hsa005610.76795073
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76234324
59Synaptic vesicle cycle_Homo sapiens_hsa047210.75900496
60Notch signaling pathway_Homo sapiens_hsa043300.75450591
61Wnt signaling pathway_Homo sapiens_hsa043100.75161533
62MicroRNAs in cancer_Homo sapiens_hsa052060.73689486
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72708648
64Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72499397
65Melanogenesis_Homo sapiens_hsa049160.72330492
66Phagosome_Homo sapiens_hsa041450.71594297
67Melanoma_Homo sapiens_hsa052180.70671206
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.70080832
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.69823627
70Chronic myeloid leukemia_Homo sapiens_hsa052200.66762419
71Glutamatergic synapse_Homo sapiens_hsa047240.66736798
72HTLV-I infection_Homo sapiens_hsa051660.66503427
73Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66441291
74Pancreatic cancer_Homo sapiens_hsa052120.65330706
75VEGF signaling pathway_Homo sapiens_hsa043700.65268924
76Endocytosis_Homo sapiens_hsa041440.64477910
77Protein digestion and absorption_Homo sapiens_hsa049740.63555554
78Fatty acid biosynthesis_Homo sapiens_hsa000610.61630567
79Dopaminergic synapse_Homo sapiens_hsa047280.60602598
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59964346
81Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59770557
82Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59551206
83Insulin secretion_Homo sapiens_hsa049110.57997000
84Dorso-ventral axis formation_Homo sapiens_hsa043200.57090119
85Basal transcription factors_Homo sapiens_hsa030220.55261307
86PPAR signaling pathway_Homo sapiens_hsa033200.55140095
87Gap junction_Homo sapiens_hsa045400.54119087
88Bladder cancer_Homo sapiens_hsa052190.53475262
89ABC transporters_Homo sapiens_hsa020100.52352413
90Colorectal cancer_Homo sapiens_hsa052100.50319711
91Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49102542
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.48226991
93Toxoplasmosis_Homo sapiens_hsa051450.47792109
94Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.47266121
95Dilated cardiomyopathy_Homo sapiens_hsa054140.46661802
96Hepatitis C_Homo sapiens_hsa051600.43814969
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.42377426
98Huntingtons disease_Homo sapiens_hsa050160.42155232
99Alcoholism_Homo sapiens_hsa050340.41631210
100Inositol phosphate metabolism_Homo sapiens_hsa005620.41574908

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