TMEM88B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.96365896
2ensheathment of neurons (GO:0007272)7.01375831
3axon ensheathment (GO:0008366)7.01375831
4myelination (GO:0042552)6.98318029
5long-chain fatty acid biosynthetic process (GO:0042759)6.23844041
6myelin maintenance (GO:0043217)5.53664134
7negative regulation of neurotransmitter secretion (GO:0046929)5.26053734
8negative regulation of neurotransmitter transport (GO:0051589)5.06663384
9cholesterol biosynthetic process (GO:0006695)4.74052154
10L-amino acid import (GO:0043092)4.67872610
11establishment of mitochondrion localization (GO:0051654)4.58304354
12negative regulation of protein localization to cell surface (GO:2000009)4.56353741
13regulation of collateral sprouting (GO:0048670)4.53789676
14oligodendrocyte differentiation (GO:0048709)4.46049648
15response to methylmercury (GO:0051597)4.41464210
16glycerophospholipid catabolic process (GO:0046475)4.34959729
17creatine metabolic process (GO:0006600)4.31936225
18positive regulation of oligodendrocyte differentiation (GO:0048714)4.30550888
19sterol biosynthetic process (GO:0016126)4.24559791
20eye photoreceptor cell differentiation (GO:0001754)4.16965844
21photoreceptor cell differentiation (GO:0046530)4.16965844
22presynaptic membrane organization (GO:0097090)4.11912369
23amyloid precursor protein metabolic process (GO:0042982)4.03959697
24apical protein localization (GO:0045176)4.03583156
25long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.00599922
26astrocyte development (GO:0014002)3.99857881
27asymmetric protein localization (GO:0008105)3.98247805
28import into cell (GO:0098657)3.87233967
29isoprenoid biosynthetic process (GO:0008299)3.73838189
30long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.72682447
31substantia nigra development (GO:0021762)3.71019851
32presynaptic membrane assembly (GO:0097105)3.67501464
33response to redox state (GO:0051775)3.65226497
34membrane tubulation (GO:0097320)3.53675001
35peptidyl-tyrosine autophosphorylation (GO:0038083)3.51232013
36regulation of lipoprotein metabolic process (GO:0050746)3.50386767
37negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.50042227
38response to lipoprotein particle (GO:0055094)3.46895463
39fatty-acyl-CoA biosynthetic process (GO:0046949)3.45598256
40amino acid import (GO:0043090)3.43117760
41protein palmitoylation (GO:0018345)3.40586458
42GPI anchor biosynthetic process (GO:0006506)3.40235476
43adult walking behavior (GO:0007628)3.37426675
44magnesium ion transport (GO:0015693)3.35965331
45GPI anchor metabolic process (GO:0006505)3.33413663
46myelination in peripheral nervous system (GO:0022011)3.30081127
47peripheral nervous system axon ensheathment (GO:0032292)3.30081127
48fatty-acyl-CoA metabolic process (GO:0035337)3.27687037
49cerebral cortex radially oriented cell migration (GO:0021799)3.23933444
50neurotransmitter uptake (GO:0001504)3.22235304
51neuron remodeling (GO:0016322)3.20276223
52limb bud formation (GO:0060174)3.19099059
53axon development (GO:0061564)3.12887201
54preassembly of GPI anchor in ER membrane (GO:0016254)3.08047965
55very long-chain fatty acid metabolic process (GO:0000038)3.06617133
56negative regulation of axonogenesis (GO:0050771)3.02597494
57glycosylceramide metabolic process (GO:0006677)3.01419637
58virion attachment to host cell (GO:0019062)2.95987729
59adhesion of symbiont to host cell (GO:0044650)2.95987729
60neuron cell-cell adhesion (GO:0007158)2.92326030
61negative regulation of execution phase of apoptosis (GO:1900118)2.87564980
62neuronal action potential propagation (GO:0019227)2.85350790
63positive regulation of glial cell differentiation (GO:0045687)2.85171575
64peptidyl-cysteine modification (GO:0018198)2.81879396
65organ growth (GO:0035265)2.81418064
66nerve growth factor signaling pathway (GO:0038180)2.81166677
67transmission of nerve impulse (GO:0019226)2.79753124
68amyloid precursor protein catabolic process (GO:0042987)2.77707599
69nucleotide transmembrane transport (GO:1901679)2.77563858
70negative regulation of JUN kinase activity (GO:0043508)2.76564123
71positive regulation of action potential (GO:0045760)2.73085809
72peripheral nervous system development (GO:0007422)2.72574744
73acyl-CoA biosynthetic process (GO:0071616)2.71780461
74thioester biosynthetic process (GO:0035384)2.71780461
75protein neddylation (GO:0045116)2.71549542
76enteric nervous system development (GO:0048484)2.68752633
77positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.67520840
78positive regulation of cellular amine metabolic process (GO:0033240)2.67439293
79glial cell development (GO:0021782)2.66028083
80positive regulation of gliogenesis (GO:0014015)2.65862101
81response to lead ion (GO:0010288)2.65657477
82leukocyte migration involved in inflammatory response (GO:0002523)2.65425986
83detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63413265
84detection of temperature stimulus involved in sensory perception (GO:0050961)2.63413265
85Golgi to endosome transport (GO:0006895)2.63276717
86cranial nerve development (GO:0021545)2.59261775
87cellular response to epinephrine stimulus (GO:0071872)2.59255947
88iron coordination entity transport (GO:1901678)2.58851064
89heme transport (GO:0015886)2.53373215
90neural nucleus development (GO:0048857)2.52535471
91microtubule polymerization or depolymerization (GO:0031109)2.51735946
92neuronal ion channel clustering (GO:0045161)2.50605626
93negative regulation of macroautophagy (GO:0016242)2.48479979
94L-phenylalanine catabolic process (GO:0006559)2.48256280
95erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.48256280
96regulation of dopamine metabolic process (GO:0042053)2.46153088
97regulation of catecholamine metabolic process (GO:0042069)2.46153088
98negative regulation of axon extension (GO:0030517)2.45827304
99axon ensheathment in central nervous system (GO:0032291)12.7247653
100central nervous system myelination (GO:0022010)12.7247653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.39938942
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.83450935
3SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.75812235
4EZH2_22144423_ChIP-Seq_EOC_Human2.63914593
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.34122690
6TAF15_26573619_Chip-Seq_HEK293_Human2.33696753
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31934529
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.22623684
9OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.13562451
10VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02102119
11EZH2_27304074_Chip-Seq_ESCs_Mouse2.00580647
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99156796
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.98441064
14MTF2_20144788_ChIP-Seq_MESCs_Mouse1.98334233
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95049242
16EZH2_18974828_ChIP-Seq_MESCs_Mouse1.95005633
17RNF2_18974828_ChIP-Seq_MESCs_Mouse1.95005633
18AR_21572438_ChIP-Seq_LNCaP_Human1.90878450
19SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.89415612
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.87328076
21VDR_22108803_ChIP-Seq_LS180_Human1.85296715
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.84549484
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82875404
24ER_23166858_ChIP-Seq_MCF-7_Human1.81749290
25* EZH2_27294783_Chip-Seq_ESCs_Mouse1.76010930
26* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.75959143
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72634246
28JARID2_20075857_ChIP-Seq_MESCs_Mouse1.69848964
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68208047
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60052880
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.58646100
32SMAD3_21741376_ChIP-Seq_EPCs_Human1.57653042
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.55199641
34STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.53178829
35DROSHA_22980978_ChIP-Seq_HELA_Human1.52891537
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.48469698
37RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.47250515
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46357032
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42217019
40TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40403462
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.40239812
42ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.39548324
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36017069
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.34652904
45P300_19829295_ChIP-Seq_ESCs_Human1.31766812
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29338704
47PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.28305683
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.27982651
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.25484556
50FUS_26573619_Chip-Seq_HEK293_Human1.23825021
51LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.23553251
52NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23068455
53NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23068455
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.22985820
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21959075
56EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.17356309
57TAL1_26923725_Chip-Seq_HPCs_Mouse1.13880731
58STAT3_23295773_ChIP-Seq_U87_Human1.13760703
59CMYC_18555785_Chip-Seq_ESCs_Mouse1.13707430
60REST_21632747_ChIP-Seq_MESCs_Mouse1.12737822
61EP300_21415370_ChIP-Seq_HL-1_Mouse1.09787368
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.08967151
63P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08821375
64EOMES_21245162_ChIP-Seq_HESCs_Human1.08457661
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07455816
66SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.07216153
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06851000
68PRDM14_20953172_ChIP-Seq_ESCs_Human1.06656240
69HTT_18923047_ChIP-ChIP_STHdh_Human1.04659937
70TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04362226
71P300_18555785_Chip-Seq_ESCs_Mouse1.03842630
72TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03362764
73UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.02975494
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.02388936
75TCF4_23295773_ChIP-Seq_U87_Human1.00219551
76SMAD4_21799915_ChIP-Seq_A2780_Human0.99919366
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99859500
78GATA1_26923725_Chip-Seq_HPCs_Mouse0.99615050
79LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98481357
80GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.97707022
81CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.97424848
82EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97170465
83RNF2_27304074_Chip-Seq_NSC_Mouse0.97097784
84TP53_16413492_ChIP-PET_HCT116_Human0.96836735
85RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96693039
86GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95000305
87IGF1R_20145208_ChIP-Seq_DFB_Human0.94935047
88* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94484429
89NANOG_19829295_ChIP-Seq_ESCs_Human0.94364109
90SOX2_19829295_ChIP-Seq_ESCs_Human0.94364109
91NR3C1_21868756_ChIP-Seq_MCF10A_Human0.93695703
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.93027305
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92861984
94REST_18959480_ChIP-ChIP_MESCs_Mouse0.91823303
95AHR_22903824_ChIP-Seq_MCF-7_Human0.89166820
96EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.88869638
97P53_22387025_ChIP-Seq_ESCs_Mouse0.87863918
98SMAD4_21741376_ChIP-Seq_EPCs_Human0.86477168
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.86068698
100E2F1_18555785_Chip-Seq_ESCs_Mouse0.85980206

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.64006488
2MP0003880_abnormal_central_pattern3.88116010
3MP0003950_abnormal_plasma_membrane3.70128688
4MP0003690_abnormal_glial_cell3.24128965
5MP0004270_analgesia3.21895204
6MP0001529_abnormal_vocalization2.90169698
7MP0003329_amyloid_beta_deposits2.77991723
8MP0004885_abnormal_endolymph2.74696683
9MP0004742_abnormal_vestibular_system2.63308680
10MP0005171_absent_coat_pigmentation2.63109492
11MP0003136_yellow_coat_color2.57659261
12MP0002272_abnormal_nervous_system2.56827845
13MP0001486_abnormal_startle_reflex2.52702121
14MP0004142_abnormal_muscle_tone2.44070942
15MP0001905_abnormal_dopamine_level2.41413052
16MP0003634_abnormal_glial_cell2.34926566
17MP0002064_seizures2.23896794
18MP0001485_abnormal_pinna_reflex2.21668284
19MP0005409_darkened_coat_color2.16726603
20MP0005423_abnormal_somatic_nervous2.15544337
21MP0000778_abnormal_nervous_system2.10707472
22MP0004859_abnormal_synaptic_plasticity2.01784970
23MP0005410_abnormal_fertilization2.00090792
24MP0003632_abnormal_nervous_system1.88711085
25MP0002229_neurodegeneration1.88494394
26MP0010678_abnormal_skin_adnexa1.83856180
27MP0009046_muscle_twitch1.79849875
28MP0004043_abnormal_pH_regulation1.76359300
29MP0009745_abnormal_behavioral_response1.73728086
30MP0003635_abnormal_synaptic_transmissio1.73255617
31MP0005451_abnormal_body_composition1.67592373
32MP0000383_abnormal_hair_follicle1.64376989
33MP0002734_abnormal_mechanical_nocicepti1.61370661
34MP0004381_abnormal_hair_follicle1.60419351
35MP0000462_abnormal_digestive_system1.56942076
36MP0003631_nervous_system_phenotype1.53235257
37MP0005551_abnormal_eye_electrophysiolog1.43980599
38MP0000955_abnormal_spinal_cord1.43056863
39MP0000604_amyloidosis1.42431031
40MP0003806_abnormal_nucleotide_metabolis1.41611196
41MP0000566_synostosis1.38747835
42MP0008260_abnormal_autophagy1.38411149
43MP0004134_abnormal_chest_morphology1.37625868
44MP0003633_abnormal_nervous_system1.36053714
45MP0002572_abnormal_emotion/affect_behav1.35180568
46MP0002882_abnormal_neuron_morphology1.34108353
47MP0008569_lethality_at_weaning1.32767136
48MP0001440_abnormal_grooming_behavior1.27617058
49MP0003195_calcinosis1.27283517
50MP0002063_abnormal_learning/memory/cond1.26499700
51MP0002066_abnormal_motor_capabilities/c1.24238329
52MP0001963_abnormal_hearing_physiology1.24206757
53MP0001970_abnormal_pain_threshold1.21325480
54MP0004147_increased_porphyrin_level1.20735212
55MP0002067_abnormal_sensory_capabilities1.17732631
56MP0002752_abnormal_somatic_nervous1.15467342
57MP0001346_abnormal_lacrimal_gland1.14928875
58MP0005386_behavior/neurological_phenoty1.14804212
59MP0004924_abnormal_behavior1.14804212
60MP0005623_abnormal_meninges_morphology1.09584942
61MP0000747_muscle_weakness1.05195472
62MP0001299_abnormal_eye_distance/1.05114574
63MP0000647_abnormal_sebaceous_gland1.04362006
64MP0003938_abnormal_ear_development1.04306789
65MP0005195_abnormal_posterior_eye1.00723281
66MP0001851_eye_inflammation0.93654075
67MP0001177_atelectasis0.93330632
68MP0002733_abnormal_thermal_nociception0.92441784
69MP0001661_extended_life_span0.90984500
70MP0004145_abnormal_muscle_electrophysio0.90695498
71MP0005058_abnormal_lysosome_morphology0.89588467
72MP0000762_abnormal_tongue_morphology0.85246459
73MP0000026_abnormal_inner_ear0.83373677
74MP0003937_abnormal_limbs/digits/tail_de0.82795503
75MP0002295_abnormal_pulmonary_circulatio0.81853989
76MP0002822_catalepsy0.81335691
77MP0002152_abnormal_brain_morphology0.79763527
78MP0001968_abnormal_touch/_nociception0.79041122
79MP0005408_hypopigmentation0.76866153
80MP0000579_abnormal_nail_morphology0.75737436
81MP0006082_CNS_inflammation0.75569809
82MP0005253_abnormal_eye_physiology0.74596084
83MP0001348_abnormal_lacrimal_gland0.72141862
84MP0002184_abnormal_innervation0.71069970
85MP0002735_abnormal_chemical_nociception0.70675600
86MP0001501_abnormal_sleep_pattern0.68375030
87MP0001502_abnormal_circadian_rhythm0.67217306
88MP0006072_abnormal_retinal_apoptosis0.66766567
89MP0003137_abnormal_impulse_conducting0.65839801
90MP0004036_abnormal_muscle_relaxation0.64901477
91MP0000467_abnormal_esophagus_morphology0.62177538
92MP0000003_abnormal_adipose_tissue0.61970354
93MP0002736_abnormal_nociception_after0.61454535
94MP0002557_abnormal_social/conspecific_i0.61367439
95MP0008438_abnormal_cutaneous_collagen0.61032949
96MP0005388_respiratory_system_phenotype0.60783939
97MP0002133_abnormal_respiratory_system0.60783939
98MP0002090_abnormal_vision0.60607110
99MP0001340_abnormal_eyelid_morphology0.57912563
100MP0003656_abnormal_erythrocyte_physiolo0.57675256

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)6.95736132
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)6.95736132
3Neurofibrillary tangles (HP:0002185)6.28904890
4Abnormality of the corticospinal tract (HP:0002492)5.13108470
5Parakeratosis (HP:0001036)4.95159944
6Peripheral hypomyelination (HP:0007182)4.63413602
7Cerebral inclusion bodies (HP:0100314)4.46184981
8Sensory axonal neuropathy (HP:0003390)4.41959841
9Onion bulb formation (HP:0003383)3.96789800
10Termporal pattern (HP:0011008)3.78842754
11Insidious onset (HP:0003587)3.78842754
12Supranuclear gaze palsy (HP:0000605)3.72173774
13Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.70850859
14Cerebral hypomyelination (HP:0006808)3.67703969
15Spastic gait (HP:0002064)3.65464076
16Abnormal auditory evoked potentials (HP:0006958)3.49676606
17Alacrima (HP:0000522)3.25649221
18Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.16345645
19Intention tremor (HP:0002080)3.13669782
20Dysmetria (HP:0001310)3.12432538
21Ankle clonus (HP:0011448)3.04869826
22Retinal dysplasia (HP:0007973)3.04866507
23Leukodystrophy (HP:0002415)3.00901678
24Myokymia (HP:0002411)2.97732603
25Abnormality of glycolysis (HP:0004366)2.93165216
26Increased serum pyruvate (HP:0003542)2.93165216
27Segmental peripheral demyelination/remyelination (HP:0003481)2.87248384
28Slow saccadic eye movements (HP:0000514)2.85870235
29Scanning speech (HP:0002168)2.85098022
30Anteriorly placed anus (HP:0001545)2.81503356
31Congenital ichthyosiform erythroderma (HP:0007431)2.69389973
32Absent septum pellucidum (HP:0001331)2.67332519
33Clumsiness (HP:0002312)2.58713169
34Hypoplastic pelvis (HP:0008839)2.58462250
35Stridor (HP:0010307)2.57424957
36Decreased lacrimation (HP:0000633)2.56482320
37Thickened helices (HP:0000391)2.56477225
38Premature skin wrinkling (HP:0100678)2.55380824
39Cerebral hemorrhage (HP:0001342)2.53211445
40Split foot (HP:0001839)2.51079236
41Autoamputation (HP:0001218)2.49646502
42CNS hypomyelination (HP:0003429)2.43156710
43Spastic paraparesis (HP:0002313)2.39795270
44Increased circulating renin level (HP:0000848)2.39410727
45Morphological abnormality of the inner ear (HP:0011390)2.39028306
46Metabolic alkalosis (HP:0200114)2.30826427
47Abnormality of the phalanges of the 2nd finger (HP:0009541)2.29322794
48Aplasia involving bones of the upper limbs (HP:0009823)2.29144843
49Aplasia of the phalanges of the hand (HP:0009802)2.29144843
50Aplasia involving bones of the extremities (HP:0009825)2.29144843
51Abnormality of the septum pellucidum (HP:0007375)2.27572721
52Coronal craniosynostosis (HP:0004440)2.25604477
53Pheochromocytoma (HP:0002666)2.23527820
54White forelock (HP:0002211)2.22604974
55Lower limb muscle weakness (HP:0007340)2.22529311
56Akinesia (HP:0002304)2.22252209
57Patchy hypopigmentation of hair (HP:0011365)2.19694555
58Foot dorsiflexor weakness (HP:0009027)2.18016043
59Hypoplasia of the iris (HP:0007676)2.16054098
60Spastic tetraparesis (HP:0001285)2.14514263
61Axonal loss (HP:0003447)2.13043008
62Hepatosplenomegaly (HP:0001433)2.11668627
63Megalencephaly (HP:0001355)2.08855209
64Hypomagnesemia (HP:0002917)2.04407095
65Partial duplication of thumb phalanx (HP:0009944)2.04115827
66Hypokalemic alkalosis (HP:0001949)2.03937087
67Synostosis involving the elbow (HP:0003938)2.02156830
68Humeroradial synostosis (HP:0003041)2.02156830
69Decreased motor nerve conduction velocity (HP:0003431)2.01884153
70Muscle fiber splitting (HP:0003555)2.01396606
71Cupped ear (HP:0000378)2.01299121
72Hypophosphatemic rickets (HP:0004912)1.97380285
73Abnormality of the foot musculature (HP:0001436)1.97338174
74Partial agenesis of the corpus callosum (HP:0001338)1.96796937
75Renal Fanconi syndrome (HP:0001994)1.95030322
76Poor speech (HP:0002465)1.94152534
77Neuroendocrine neoplasm (HP:0100634)1.93135425
78Clonus (HP:0002169)1.92062300
79Methylmalonic acidemia (HP:0002912)1.91540652
80Infantile muscular hypotonia (HP:0008947)1.90473538
81Abnormality of the middle phalanges of the toes (HP:0010183)1.89146671
82Esophageal atresia (HP:0002032)1.86311235
83Bowel incontinence (HP:0002607)1.86032993
843-Methylglutaconic aciduria (HP:0003535)1.85107823
85Morphological abnormality of the pyramidal tract (HP:0002062)1.84456065
86Action tremor (HP:0002345)1.84116018
87Urinary incontinence (HP:0000020)1.83740573
88Gowers sign (HP:0003391)1.83001506
89Choreoathetosis (HP:0001266)1.82374330
90Urinary urgency (HP:0000012)1.81617838
91Hammertoe (HP:0001765)1.81541696
92Paraparesis (HP:0002385)1.80425182
93Focal motor seizures (HP:0011153)1.78111646
94Abnormal large intestine physiology (HP:0012700)1.74081455
95Erythroderma (HP:0001019)1.72374098
96Partial duplication of the phalanx of hand (HP:0009999)1.70137394
97Distal sensory impairment (HP:0002936)1.70108687
98Adrenal hypoplasia (HP:0000835)1.69207441
99Diaphragmatic weakness (HP:0009113)1.67768873
100Abnormality of aromatic amino acid family metabolism (HP:0004338)1.66908027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.29152949
2OXSR14.55851319
3EPHB13.61097443
4PKN12.76747431
5PBK2.74475818
6MAPKAPK52.67575032
7BCR2.67317417
8CDK192.47053542
9WNK42.43414839
10MET2.36629883
11FGFR22.24203884
12WNK12.06302513
13TESK21.91811824
14LIMK11.91733705
15UHMK11.85264633
16TNIK1.75366535
17PNCK1.72860584
18CSNK1G31.71653945
19CAMK2B1.69923922
20CSNK1A1L1.66709789
21NEK61.63185432
22NTRK11.57576473
23MST41.50974333
24ROCK21.49777821
25ICK1.44252706
26CLK11.43615001
27FGR1.42964088
28CAMK2D1.39589555
29CSNK1G11.35400214
30CASK1.33814379
31CSNK1G21.26466109
32SGK4941.23577393
33SGK2231.23577393
34PAK61.21648906
35EPHA41.14299242
36CAMK2G1.09648574
37PRPF4B1.08287684
38MUSK1.03806381
39DYRK20.99777571
40MARK10.97154460
41TYRO30.91331926
42CAMK2A0.88216495
43MARK20.85183710
44CDK50.83211141
45CDK140.82145672
46PAK30.81976502
47PRKCQ0.80101403
48MAPK150.77540624
49PRKD10.76509614
50CDK150.72622502
51PRKCE0.68557240
52CDK180.67313581
53ERBB40.67153043
54BMPR1B0.66510960
55IRAK20.64916863
56CDK11A0.64663372
57PHKG20.63960605
58PHKG10.63960605
59RPS6KA50.62938804
60ARAF0.62733107
61PDPK10.58233847
62FYN0.53656320
63CSNK1D0.51051715
64TRPM70.49754232
65PRKG10.48854103
66GSK3A0.48719615
67NTRK20.48650265
68MAPK130.46931149
69STK110.43433171
70CSNK1A10.43029282
71PRKACB0.42270179
72MAP3K130.42152385
73MKNK10.41616761
74MAP2K20.41596951
75KSR20.41023091
76FES0.38146549
77CAMK1G0.37027495
78PIK3CA0.37009654
79DMPK0.36872515
80PRKCH0.36751854
81PAK10.35894148
82ADRBK20.34865144
83PINK10.32979805
84BMX0.32910135
85MAPK70.32731231
86BMPR20.31669753
87PDGFRB0.31646036
88PTK2B0.30970947
89OBSCN0.30904518
90GRK70.30141555
91DAPK30.29836699
92PRKACA0.29734657
93INSR0.28148989
94DYRK1A0.26864418
95PRKD30.26430129
96PDK10.25197944
97ITK0.24292183
98CSNK1E0.23136165
99SGK10.22828916
100MAPK100.22587053

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.36818111
2Steroid biosynthesis_Homo sapiens_hsa001004.58443560
3Fatty acid elongation_Homo sapiens_hsa000624.50186275
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.30614458
5Ether lipid metabolism_Homo sapiens_hsa005653.19893865
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.16100450
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.52874742
8Sulfur metabolism_Homo sapiens_hsa009202.03907307
9Vitamin B6 metabolism_Homo sapiens_hsa007502.02872611
10Protein export_Homo sapiens_hsa030601.94692517
11Oxidative phosphorylation_Homo sapiens_hsa001901.85981224
12Histidine metabolism_Homo sapiens_hsa003401.84333393
13Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84327891
14Nitrogen metabolism_Homo sapiens_hsa009101.83742011
15Sphingolipid metabolism_Homo sapiens_hsa006001.82315575
16Linoleic acid metabolism_Homo sapiens_hsa005911.68493952
17Axon guidance_Homo sapiens_hsa043601.67694436
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.50838228
19GABAergic synapse_Homo sapiens_hsa047271.44037002
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39650160
21Parkinsons disease_Homo sapiens_hsa050121.36057161
22Glutamatergic synapse_Homo sapiens_hsa047241.35712486
23Butanoate metabolism_Homo sapiens_hsa006501.35305882
24Serotonergic synapse_Homo sapiens_hsa047261.33439336
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.27015901
26Alzheimers disease_Homo sapiens_hsa050101.25851950
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12775968
28Arginine and proline metabolism_Homo sapiens_hsa003301.11822280
29Morphine addiction_Homo sapiens_hsa050321.10559488
30Renal cell carcinoma_Homo sapiens_hsa052111.08628609
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06236260
32Long-term depression_Homo sapiens_hsa047301.05199063
33Sphingolipid signaling pathway_Homo sapiens_hsa040710.91675661
34Collecting duct acid secretion_Homo sapiens_hsa049660.91221919
35Vibrio cholerae infection_Homo sapiens_hsa051100.88160900
36Tight junction_Homo sapiens_hsa045300.86962412
37Arachidonic acid metabolism_Homo sapiens_hsa005900.84757839
38Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84397190
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80699702
40Cocaine addiction_Homo sapiens_hsa050300.80496233
41Circadian entrainment_Homo sapiens_hsa047130.78702852
42Cardiac muscle contraction_Homo sapiens_hsa042600.75380230
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72845886
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.72486629
45Ras signaling pathway_Homo sapiens_hsa040140.71494038
46Salivary secretion_Homo sapiens_hsa049700.71268520
47Autoimmune thyroid disease_Homo sapiens_hsa053200.69183531
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.68813056
49Folate biosynthesis_Homo sapiens_hsa007900.68734281
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68336708
51Phototransduction_Homo sapiens_hsa047440.67765834
52Vascular smooth muscle contraction_Homo sapiens_hsa042700.67157701
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66381583
54Endocytosis_Homo sapiens_hsa041440.65815193
55Rheumatoid arthritis_Homo sapiens_hsa053230.65253208
56Nicotine addiction_Homo sapiens_hsa050330.64947962
57Ovarian steroidogenesis_Homo sapiens_hsa049130.64756457
58Gastric acid secretion_Homo sapiens_hsa049710.64455090
59Fatty acid metabolism_Homo sapiens_hsa012120.64132330
60Glutathione metabolism_Homo sapiens_hsa004800.63472030
61Propanoate metabolism_Homo sapiens_hsa006400.62943483
62Dorso-ventral axis formation_Homo sapiens_hsa043200.61309914
63Cholinergic synapse_Homo sapiens_hsa047250.60703103
64Dopaminergic synapse_Homo sapiens_hsa047280.59933420
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.59616077
66Mineral absorption_Homo sapiens_hsa049780.57111684
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57104525
68Lysosome_Homo sapiens_hsa041420.57098537
69Huntingtons disease_Homo sapiens_hsa050160.56449824
70Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55566822
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.55550231
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55064858
73Pancreatic secretion_Homo sapiens_hsa049720.51712331
74ErbB signaling pathway_Homo sapiens_hsa040120.49959871
75Phagosome_Homo sapiens_hsa041450.47185076
76Peroxisome_Homo sapiens_hsa041460.47098795
77Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.46409253
78Synaptic vesicle cycle_Homo sapiens_hsa047210.46393503
79Hedgehog signaling pathway_Homo sapiens_hsa043400.42814066
80Fatty acid biosynthesis_Homo sapiens_hsa000610.42262152
81Taste transduction_Homo sapiens_hsa047420.41413451
82Renin secretion_Homo sapiens_hsa049240.40723712
83Metabolic pathways_Homo sapiens_hsa011000.39896536
84Vitamin digestion and absorption_Homo sapiens_hsa049770.39638397
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.38880174
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37430776
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37215602
88Gap junction_Homo sapiens_hsa045400.36735504
89Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35558279
90cAMP signaling pathway_Homo sapiens_hsa040240.32058766
91Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30234967
92Prion diseases_Homo sapiens_hsa050200.30004966
93Amphetamine addiction_Homo sapiens_hsa050310.29201858
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29059368
95Choline metabolism in cancer_Homo sapiens_hsa052310.28783229
96Chemical carcinogenesis_Homo sapiens_hsa052040.28557329
97Retinol metabolism_Homo sapiens_hsa008300.26660325
98ECM-receptor interaction_Homo sapiens_hsa045120.25985937
99Regulation of autophagy_Homo sapiens_hsa041400.25143792
100Malaria_Homo sapiens_hsa051440.24879068

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