TMEM88

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.92295311
2translational termination (GO:0006415)6.69506789
3ribosomal small subunit biogenesis (GO:0042274)6.15684814
4cardiac ventricle formation (GO:0003211)5.96160645
5endothelium development (GO:0003158)5.93308985
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.89072832
7cotranslational protein targeting to membrane (GO:0006613)5.83850654
8ribosomal small subunit assembly (GO:0000028)5.80004966
9protein targeting to ER (GO:0045047)5.78858945
10cardiac chamber formation (GO:0003207)5.75985536
11maturation of SSU-rRNA (GO:0030490)5.73900505
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.65691480
13translational elongation (GO:0006414)5.62324492
14ribosomal large subunit biogenesis (GO:0042273)5.55555636
15establishment of protein localization to endoplasmic reticulum (GO:0072599)5.49869773
16protein localization to endoplasmic reticulum (GO:0070972)5.42913053
17energy coupled proton transport, down electrochemical gradient (GO:0015985)5.33286183
18ATP synthesis coupled proton transport (GO:0015986)5.33286183
19cellular protein complex disassembly (GO:0043624)5.20751291
20viral life cycle (GO:0019058)5.20521917
21translational initiation (GO:0006413)4.90946859
22nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.90559225
23cartilage morphogenesis (GO:0060536)4.75922391
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.60526393
25negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.47700280
26protein complex disassembly (GO:0043241)4.46223012
27lymph vessel development (GO:0001945)4.41601104
28DNA deamination (GO:0045006)4.41376805
29macromolecular complex disassembly (GO:0032984)4.30234294
30heart valve formation (GO:0003188)4.25365399
31translation (GO:0006412)4.24206641
32trophoblast giant cell differentiation (GO:0060707)4.24039249
33respiratory electron transport chain (GO:0022904)4.18649863
34termination of RNA polymerase III transcription (GO:0006386)4.14749778
35transcription elongation from RNA polymerase III promoter (GO:0006385)4.14749778
36proteasome assembly (GO:0043248)4.11505490
37electron transport chain (GO:0022900)4.09731792
38endothelial tube morphogenesis (GO:0061154)4.08263501
39morphogenesis of an endothelium (GO:0003159)4.08263501
40GTP biosynthetic process (GO:0006183)3.84732187
41positive regulation of vasculogenesis (GO:2001214)3.83160761
42protein targeting to membrane (GO:0006612)3.80645955
43lung morphogenesis (GO:0060425)3.74298580
44ribonucleoprotein complex biogenesis (GO:0022613)3.72470372
45spliceosomal complex assembly (GO:0000245)3.66173155
46cullin deneddylation (GO:0010388)3.65205437
47short-term memory (GO:0007614)3.62075896
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.61628944
49mitochondrial respiratory chain complex I assembly (GO:0032981)3.61628944
50NADH dehydrogenase complex assembly (GO:0010257)3.61628944
51spliceosomal snRNP assembly (GO:0000387)3.61144590
52positive regulation of heat generation (GO:0031652)3.59699190
53DNA damage response, detection of DNA damage (GO:0042769)3.55257970
54nuclear-transcribed mRNA catabolic process (GO:0000956)3.54913470
55positive regulation of endothelial cell differentiation (GO:0045603)3.52325315
56regulation of glycogen (starch) synthase activity (GO:2000465)3.50407766
57axon extension involved in axon guidance (GO:0048846)3.48934974
58neuron projection extension involved in neuron projection guidance (GO:1902284)3.48934974
59leukocyte migration involved in inflammatory response (GO:0002523)3.48659460
60somite development (GO:0061053)3.48096584
61protein neddylation (GO:0045116)3.48004517
62neutrophil activation involved in immune response (GO:0002283)3.47251304
63cell proliferation in forebrain (GO:0021846)3.43804846
64UTP biosynthetic process (GO:0006228)3.43085039
65positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.41170425
66protein complex biogenesis (GO:0070271)3.41129411
67establishment of integrated proviral latency (GO:0075713)3.41116875
68cardiac muscle tissue morphogenesis (GO:0055008)3.36499364
69protein deneddylation (GO:0000338)3.34362956
70mRNA catabolic process (GO:0006402)3.31881638
71mitochondrial respiratory chain complex assembly (GO:0033108)3.31259624
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.31083554
73cellular component biogenesis (GO:0044085)3.30995977
74regulation of mitochondrial translation (GO:0070129)3.25663608
75ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.23509258
76establishment of viral latency (GO:0019043)3.21754300
777-methylguanosine mRNA capping (GO:0006370)3.21674137
78bundle of His cell to Purkinje myocyte communication (GO:0086069)3.17986922
79embryonic heart tube development (GO:0035050)3.17165859
80pseudouridine synthesis (GO:0001522)3.16836735
81RNA capping (GO:0036260)3.13502125
827-methylguanosine RNA capping (GO:0009452)3.13502125
83positive regulation of urine volume (GO:0035810)3.13164762
84rRNA processing (GO:0006364)3.12662912
85negative regulation of striated muscle cell apoptotic process (GO:0010664)3.12553983
86guanosine-containing compound biosynthetic process (GO:1901070)3.12498653
87branching involved in labyrinthine layer morphogenesis (GO:0060670)3.09742933
88cell migration involved in heart development (GO:0060973)3.07966212
89cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.07357535
90regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901213.06870638
91negative regulation of ligase activity (GO:0051352)3.06783731
92negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.06783731
93DNA replication checkpoint (GO:0000076)3.06109948
94RNA catabolic process (GO:0006401)3.05976826
95positive regulation of T cell apoptotic process (GO:0070234)3.05803185
96muscle tissue morphogenesis (GO:0060415)3.04260471
97endoderm formation (GO:0001706)3.02618310
98lymphangiogenesis (GO:0001946)3.00217920
99positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99890758
100oxidative phosphorylation (GO:0006119)2.98291417
101rRNA metabolic process (GO:0016072)2.96369855
102telomere maintenance via semi-conservative replication (GO:0032201)2.96320046
103DNA strand elongation involved in DNA replication (GO:0006271)2.94509032
104exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93791682
105regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.92979254
106transcription-coupled nucleotide-excision repair (GO:0006283)2.92872324
107negative regulation of interleukin-1 beta production (GO:0032691)2.92622764
108actin-myosin filament sliding (GO:0033275)2.92104753
109muscle filament sliding (GO:0030049)2.92104753
110UTP metabolic process (GO:0046051)2.90118815
111regulation of fever generation (GO:0031620)2.89804232
112anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.89717931
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.89272106
114heart trabecula formation (GO:0060347)2.88207848
115positive regulation of protein kinase C signaling (GO:0090037)2.88003849
116cardiovascular system development (GO:0072358)2.87684445
117regulation of vasculogenesis (GO:2001212)2.87015114
118protein targeting to mitochondrion (GO:0006626)2.86386693
119CENP-A containing nucleosome assembly (GO:0034080)2.83916401
120viral mRNA export from host cell nucleus (GO:0046784)2.83719442
121ncRNA 3-end processing (GO:0043628)2.83404755
122spinal cord association neuron differentiation (GO:0021527)2.83385967
123deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83158656
124positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.82597297
125negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.79691143
126regulation of heterotypic cell-cell adhesion (GO:0034114)2.79651572
127establishment of protein localization to mitochondrion (GO:0072655)2.79570202
128DNA strand elongation (GO:0022616)2.78368352
129CTP biosynthetic process (GO:0006241)2.77635025
130CTP metabolic process (GO:0046036)2.77635025
131regulation of cellular amino acid metabolic process (GO:0006521)2.76696768
132DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.75559720
133negative chemotaxis (GO:0050919)2.74775832
134chromatin remodeling at centromere (GO:0031055)2.74082921
135positive regulation of NF-kappaB import into nucleus (GO:0042346)2.73528952
136gap junction assembly (GO:0016264)2.73183921
137endothelial cell differentiation (GO:0045446)2.73052168
138regulation of endothelial cell differentiation (GO:0045601)2.72476974
139granulocyte activation (GO:0036230)2.72190473
140thrombin receptor signaling pathway (GO:0070493)2.71656583
141pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.71495512
142pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.71198245
143ventricular trabecula myocardium morphogenesis (GO:0003222)2.71196910
144purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70540923
145atrioventricular valve morphogenesis (GO:0003181)2.69440118
146tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.68427481
147RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.68427481
148cell migration in hindbrain (GO:0021535)2.68218259
149signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67978021
150intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67978021
151negative regulation of interleukin-12 production (GO:0032695)2.67830432
152neutrophil activation (GO:0042119)2.64643165
153negative regulation of Rho protein signal transduction (GO:0035024)2.63452475
154positive regulation of BMP signaling pathway (GO:0030513)2.60619581
155regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.60265614
156negative regulation of interleukin-1 production (GO:0032692)2.60240777
157regulation of cardioblast differentiation (GO:0051890)2.59671230
158establishment of protein localization to mitochondrial membrane (GO:0090151)2.59177316
159venous blood vessel morphogenesis (GO:0048845)2.58422899
160trabecula morphogenesis (GO:0061383)2.56443662
161positive regulation of lymphocyte apoptotic process (GO:0070230)2.56318708
162negative regulation of ERK1 and ERK2 cascade (GO:0070373)2.56140929
163response to peptidoglycan (GO:0032494)2.55745601
164cardiac septum morphogenesis (GO:0060411)2.53564931
165atrial cardiac muscle cell action potential (GO:0086014)2.52331266
166artery development (GO:0060840)2.49070286
167germinal center formation (GO:0002467)2.49021705
168regulation of skeletal muscle contraction (GO:0014819)2.48217920
169vascular endothelial growth factor signaling pathway (GO:0038084)2.47034748
170tongue development (GO:0043586)2.45436959
171embryonic digestive tract morphogenesis (GO:0048557)2.45258287
172cellular response to BMP stimulus (GO:0071773)2.44932305
173response to BMP (GO:0071772)2.44932305
174positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.44864579
175negative regulation of toll-like receptor signaling pathway (GO:0034122)2.44700524
176regulation of thymocyte apoptotic process (GO:0070243)2.43446749
177cardiac left ventricle morphogenesis (GO:0003214)2.43352208
178positive regulation of protein homooligomerization (GO:0032464)2.42823747
179actin-mediated cell contraction (GO:0070252)2.42685996
180respiratory system process (GO:0003016)2.41035717
181cellular response to ATP (GO:0071318)2.40364894
182regulation of heat generation (GO:0031650)2.39237132
183regulation of NF-kappaB import into nucleus (GO:0042345)2.37743044
184embryonic camera-type eye development (GO:0031076)2.37314229
185lens morphogenesis in camera-type eye (GO:0002089)2.37128735
186positive regulation of cardiac muscle cell differentiation (GO:2000727)2.36732695
187positive regulation by symbiont of host defense response (GO:0052509)2.36447042
188modulation by symbiont of host defense response (GO:0052031)2.36447042
189modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.36447042
190modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.36447042
191positive regulation by organism of defense response of other organism involved in symbiotic interact2.36447042
192modulation by symbiont of host immune response (GO:0052553)2.36447042
193neuron fate determination (GO:0048664)2.36395319
194phosphatidylglycerol biosynthetic process (GO:0006655)2.36015253

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.85951947
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.64222376
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.58063635
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.51399464
5GABP_17652178_ChIP-ChIP_JURKAT_Human4.13249394
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.95151442
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86990446
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.60035216
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.50137404
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.49700997
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.45305833
12MYC_19079543_ChIP-ChIP_MESCs_Mouse3.36377069
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.32690856
14CREB1_15753290_ChIP-ChIP_HEK293T_Human3.28308505
15EZH2_22144423_ChIP-Seq_EOC_Human3.23149985
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.21929848
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.93044461
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.92851656
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.85247118
20XRN2_22483619_ChIP-Seq_HELA_Human2.78111341
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.72175589
22STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.70768049
23E2F7_22180533_ChIP-Seq_HELA_Human2.70554650
24TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.52463114
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.51333722
26* TTF2_22483619_ChIP-Seq_HELA_Human2.50313437
27DCP1A_22483619_ChIP-Seq_HELA_Human2.36470404
28CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.32316651
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.27420461
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26547182
31VDR_23849224_ChIP-Seq_CD4+_Human2.20435914
32NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16955675
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.09398058
34THAP11_20581084_ChIP-Seq_MESCs_Mouse2.07608516
35EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.06712289
36IKZF1_21737484_ChIP-ChIP_HCT116_Human2.04556477
37ELK1_19687146_ChIP-ChIP_HELA_Human2.01613465
38YY1_21170310_ChIP-Seq_MESCs_Mouse2.01081288
39FOXP3_21729870_ChIP-Seq_TREG_Human2.00786021
40KDM2B_26808549_Chip-Seq_SUP-B15_Human1.96757593
41ISL1_27105846_Chip-Seq_CPCs_Mouse1.95688031
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.95426878
43SRF_21415370_ChIP-Seq_HL-1_Mouse1.92986658
44E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92471192
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.85544206
46GABP_19822575_ChIP-Seq_HepG2_Human1.85542830
47KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.80730282
48ELK1_22589737_ChIP-Seq_MCF10A_Human1.79642161
49SOX2_18555785_ChIP-Seq_MESCs_Mouse1.79192459
50MYC_18940864_ChIP-ChIP_HL60_Human1.78694672
51* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.77740391
52KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75119845
53KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75119845
54KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75119845
55VDR_21846776_ChIP-Seq_THP-1_Human1.73926041
56* ELK3_25401928_ChIP-Seq_HUVEC_Human1.69147821
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.68895127
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.68755091
59MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67092442
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65074632
61THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64065017
62SUZ12_27294783_Chip-Seq_ESCs_Mouse1.64045110
63TP53_20018659_ChIP-ChIP_R1E_Mouse1.61848578
64EED_16625203_ChIP-ChIP_MESCs_Mouse1.58978669
65POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.58904317
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.55973348
67RBPJ_22232070_ChIP-Seq_NCS_Mouse1.55183078
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.53216195
69KDM2B_26808549_Chip-Seq_K562_Human1.50967611
70* KDM2B_26808549_Chip-Seq_DND41_Human1.50588023
71TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.49369162
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.47408466
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.47085591
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.46842799
75EZH2_18974828_ChIP-Seq_MESCs_Mouse1.46385753
76RNF2_18974828_ChIP-Seq_MESCs_Mouse1.46385753
77JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45944666
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.40986028
79OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.39431759
80SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39264219
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.39136929
82* CTCF_27219007_Chip-Seq_Bcells_Human1.37611886
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36149571
84RING1B_27294783_Chip-Seq_ESCs_Mouse1.35272941
85VDR_24763502_ChIP-Seq_THP-1_Human1.33634488
86* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.32333385
87ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.31983538
88CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31932163
89* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31270442
90SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.31164512
91* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.28344870
92MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.26935848
93* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25983049
94SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.23462112
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.21495342
96LXR_22292898_ChIP-Seq_THP-1_Human1.21458476
97YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20903141
98POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.19774812
99TCF3_18692474_ChIP-Seq_MEFs_Mouse1.19081032
100ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18860185
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.18259978
102* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.17817680
103SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17240813
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16793500
105STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.16509492
106TCF7_22412390_ChIP-Seq_EML_Mouse1.16233159
107SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15921773
108OCT4_18692474_ChIP-Seq_MEFs_Mouse1.15103710
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14658463
110TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14057138
111NFIB_24661679_ChIP-Seq_LUNG_Mouse1.13086772
112* KDM2B_26808549_Chip-Seq_JURKAT_Human1.12190309
113SOX17_20123909_ChIP-Seq_XEN_Mouse1.11655727
114PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11210013
115RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10714655
116CTCF_18555785_ChIP-Seq_MESCs_Mouse1.09909762
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08278045
118EOMES_21245162_ChIP-Seq_HESCs_Human1.07497396
119HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07191096
120* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.07099491
121NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06362979
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06338072
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.06243217
124STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06228645
125ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06023686
126SA1_27219007_Chip-Seq_Bcells_Human1.06014870
127PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.05577234
128SMAD3_21741376_ChIP-Seq_HESCs_Human1.05023455
129CBX2_27304074_Chip-Seq_ESCs_Mouse1.04210775
130MYC_27129775_Chip-Seq_CORNEA_Mouse1.01906187
131RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01868337
132ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.01345623
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00350560
134SOX2_16153702_ChIP-ChIP_HESCs_Human0.99354921
135PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.98959441
136* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97143928
137TP63_19390658_ChIP-ChIP_HaCaT_Human0.96966314
138FOXM1_23109430_ChIP-Seq_U2OS_Human0.96676032
139GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96636293
140P68_20966046_ChIP-Seq_HELA_Human0.96389043
141POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95732847
142IRF8_27001747_Chip-Seq_BMDM_Mouse0.95621965
143SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95185185
144RING1B_27294783_Chip-Seq_NPCs_Mouse0.94472947
145SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.93653215
146* GATA2_21666600_ChIP-Seq_HMVEC_Human0.93518716
147STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.93438606
148KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93431915
149RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93101848
150TP63_17297297_ChIP-ChIP_HaCaT_Human0.93031668
151CIITA_25753668_ChIP-Seq_RAJI_Human0.92879952
152MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.92849918
153SMAD4_21741376_ChIP-Seq_HESCs_Human0.92330194
154SA1_27219007_Chip-Seq_ERYTHROID_Human0.90503086
155* CTCF_21964334_ChIP-Seq_BJAB-B_Human0.90478200
156KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.90335775
157EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.90200789
158NANOG_16153702_ChIP-ChIP_HESCs_Human0.90034184
159CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.89344890
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89207042
161MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.89181677
162TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.89167812
163UTX_26944678_Chip-Seq_JUKART_Human0.88359664
164ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.88340917
165CTCF_27219007_Chip-Seq_ERYTHROID_Human0.88225305
166TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87854500
167SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.87611948
168CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87272735
169SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.86279077
170BCL6_27268052_Chip-Seq_Bcells_Human0.85385950
171SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.83483027
172* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.83049676
173BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82914820
174AR_21909140_ChIP-Seq_LNCAP_Human0.82685721
175PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.82002112
176HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81577261
177IRF1_19129219_ChIP-ChIP_H3396_Human0.79269315
178NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76687151
179SRY_22984422_ChIP-ChIP_TESTIS_Rat0.76392412
180YY1_22570637_ChIP-Seq_MALME-3M_Human0.75524885
181HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75392161
182WT1_19549856_ChIP-ChIP_CCG9911_Human0.74203956
183EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74099589
184SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.73132583

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.05771658
2MP0001879_abnormal_lymphatic_vessel4.40213836
3MP0010368_abnormal_lymphatic_system4.17962398
4MP0003303_peritoneal_inflammation3.57008385
5MP0004264_abnormal_extraembryonic_tissu2.84018548
6MP0003122_maternal_imprinting2.81516695
7MP0004272_abnormal_basement_membrane2.80556481
8MP0005167_abnormal_blood-brain_barrier2.77094066
9MP0004510_myositis2.47185779
10MP0004084_abnormal_cardiac_muscle2.45214559
11MP0002653_abnormal_ependyma_morphology2.31009809
12MP0005248_abnormal_Harderian_gland2.30637225
13MP0004215_abnormal_myocardial_fiber2.29142474
14MP0002127_abnormal_cardiovascular_syste2.22081051
15MP0008789_abnormal_olfactory_epithelium2.14637895
16MP0003828_pulmonary_edema2.12902589
17MP0001293_anophthalmia2.03774189
18MP0003123_paternal_imprinting2.01723156
19MP0008932_abnormal_embryonic_tissue1.96256262
20MP0005377_hearing/vestibular/ear_phenot1.90689341
21MP0003878_abnormal_ear_physiology1.90689341
22MP0005409_darkened_coat_color1.89968267
23MP0003724_increased_susceptibility_to1.88987386
24MP0001188_hyperpigmentation1.87924314
25MP0010030_abnormal_orbit_morphology1.86678885
26MP0006054_spinal_hemorrhage1.86520444
27MP0004133_heterotaxia1.84383490
28MP0004957_abnormal_blastocyst_morpholog1.81396555
29MP0003941_abnormal_skin_development1.80429678
30MP0002332_abnormal_exercise_endurance1.79122343
31MP0005394_taste/olfaction_phenotype1.78100588
32MP0005499_abnormal_olfactory_system1.78100588
33MP0006138_congestive_heart_failure1.76151170
34MP0003693_abnormal_embryo_hatching1.74407103
35MP0000049_abnormal_middle_ear1.74171536
36MP0005330_cardiomyopathy1.73705849
37MP0003315_abnormal_perineum_morphology1.73240010
38MP0000749_muscle_degeneration1.71607852
39MP0003567_abnormal_fetal_cardiomyocyte1.71536035
40MP0003385_abnormal_body_wall1.67137476
41MP0003950_abnormal_plasma_membrane1.64776032
42MP0003121_genomic_imprinting1.55083053
43MP0000428_abnormal_craniofacial_morphol1.54878527
44MP0009764_decreased_sensitivity_to1.53501310
45MP0004147_increased_porphyrin_level1.52016772
46MP0003119_abnormal_digestive_system1.50216797
47MP0009697_abnormal_copulation1.48051682
48MP0004145_abnormal_muscle_electrophysio1.46169537
49MP0000750_abnormal_muscle_regeneration1.43022655
50MP0002972_abnormal_cardiac_muscle1.42495658
51MP0004036_abnormal_muscle_relaxation1.39547250
52MP0002837_dystrophic_cardiac_calcinosis1.39214453
53MP0002254_reproductive_system_inflammat1.34136625
54MP0001544_abnormal_cardiovascular_syste1.31217363
55MP0005385_cardiovascular_system_phenoty1.31217363
56MP0003136_yellow_coat_color1.30938224
57MP0003890_abnormal_embryonic-extraembry1.30725027
58MP0003195_calcinosis1.29372959
59MP0003436_decreased_susceptibility_to1.28236095
60MP0000767_abnormal_smooth_muscle1.24994427
61MP0000751_myopathy1.23858232
62MP0003077_abnormal_cell_cycle1.23360410
63MP0004085_abnormal_heartbeat1.20486630
64MP0010630_abnormal_cardiac_muscle1.18852679
65MP0002938_white_spotting1.18100782
66MP0005595_abnormal_vascular_smooth1.16838482
67MP0002138_abnormal_hepatobiliary_system1.15823195
68MP0009278_abnormal_bone_marrow1.14123326
69MP0001986_abnormal_taste_sensitivity1.12668143
70MP0000762_abnormal_tongue_morphology1.11641338
71MP0006292_abnormal_olfactory_placode1.11615711
72MP0005171_absent_coat_pigmentation1.11367126
73MP0003111_abnormal_nucleus_morphology1.11191007
74MP0008007_abnormal_cellular_replicative1.10688502
75MP0005084_abnormal_gallbladder_morpholo1.09948223
76MP0003786_premature_aging1.09393801
77MP0003137_abnormal_impulse_conducting1.09392259
78MP0003718_maternal_effect1.07543411
79MP0000465_gastrointestinal_hemorrhage1.07282424
80MP0000343_altered_response_to1.07206076
81MP0004484_altered_response_of1.06563915
82MP0005620_abnormal_muscle_contractility1.06319872
83MP0003984_embryonic_growth_retardation1.03040518
84MP0002088_abnormal_embryonic_growth/wei1.02255409
85MP0001697_abnormal_embryo_size1.00774162
86MP0000566_synostosis0.99841483
87MP0008775_abnormal_heart_ventricle0.99473465
88MP0001672_abnormal_embryogenesis/_devel0.98852248
89MP0005380_embryogenesis_phenotype0.98852248
90MP0002092_abnormal_eye_morphology0.96951196
91MP0006036_abnormal_mitochondrial_physio0.96883960
92MP0009053_abnormal_anal_canal0.95501933
93MP0003938_abnormal_ear_development0.95013140
94MP0001286_abnormal_eye_development0.94068018
95MP0008057_abnormal_DNA_replication0.93961507
96MP0000778_abnormal_nervous_system0.93223125
97MP0003011_delayed_dark_adaptation0.92646929
98MP0003787_abnormal_imprinting0.92627564
99MP0010094_abnormal_chromosome_stability0.92300621
100MP0002925_abnormal_cardiovascular_devel0.91219739
101MP0003942_abnormal_urinary_system0.90298758
102MP0002163_abnormal_gland_morphology0.89476439
103MP0002132_abnormal_respiratory_system0.89448577
104MP0004381_abnormal_hair_follicle0.89293378
105MP0001730_embryonic_growth_arrest0.88864234
106MP0004130_abnormal_muscle_cell0.87668429
107MP0002697_abnormal_eye_size0.87639122
108MP0003279_aneurysm0.86536828
109MP0002249_abnormal_larynx_morphology0.85924260
110MP0008058_abnormal_DNA_repair0.83234739
111MP0001905_abnormal_dopamine_level0.83078733
112MP0002102_abnormal_ear_morphology0.82495449
113MP0000266_abnormal_heart_morphology0.82272160
114MP0009250_abnormal_appendicular_skeleto0.81644805
115MP0002419_abnormal_innate_immunity0.81563939
116MP0005165_increased_susceptibility_to0.78974620
117MP0002085_abnormal_embryonic_tissue0.78539008
118MP0002233_abnormal_nose_morphology0.78037287
119MP0003937_abnormal_limbs/digits/tail_de0.77110474
120MP0001727_abnormal_embryo_implantation0.77075440
121MP0005369_muscle_phenotype0.76908941
122MP0002638_abnormal_pupillary_reflex0.76682100
123MP0003646_muscle_fatigue0.76585427
124MP0004087_abnormal_muscle_fiber0.76485795
125MP0001614_abnormal_blood_vessel0.76335317
126MP0001663_abnormal_digestive_system0.75695575
127MP0002277_abnormal_respiratory_mucosa0.75235268
128MP0002106_abnormal_muscle_physiology0.75041185
129MP0008004_abnormal_stomach_pH0.75035978
130MP0005193_abnormal_anterior_eye0.74989479
131MP0005670_abnormal_white_adipose0.73596464
132MP0000537_abnormal_urethra_morphology0.72248201
133MP0000516_abnormal_urinary_system0.72192246
134MP0005367_renal/urinary_system_phenotyp0.72192246
135MP0002177_abnormal_outer_ear0.71237505
136MP0005423_abnormal_somatic_nervous0.70470555
137MP0003221_abnormal_cardiomyocyte_apopto0.70226806
138MP0000249_abnormal_blood_vessel0.70023481
139MP0002128_abnormal_blood_circulation0.70010025
140MP0005464_abnormal_platelet_physiology0.69986286
141MP0004883_abnormal_blood_vessel0.69542302
142MP0001849_ear_inflammation0.69435234
143MP0002080_prenatal_lethality0.69338353
144MP0001529_abnormal_vocalization0.66238912
145MP0001533_abnormal_skeleton_physiology0.62289353
146MP0005391_vision/eye_phenotype0.61179833

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.61308246
2Mitochondrial inheritance (HP:0001427)5.15707498
3Reticulocytopenia (HP:0001896)5.13261276
4Abnormal mitochondria in muscle tissue (HP:0008316)5.07424338
5Hepatocellular necrosis (HP:0001404)4.78416564
6Abnormality of cells of the erythroid lineage (HP:0012130)4.48169858
7Progressive macrocephaly (HP:0004481)4.46843988
8Acute encephalopathy (HP:0006846)4.44613450
9Increased CSF lactate (HP:0002490)4.38613044
10Anophthalmia (HP:0000528)4.24009148
11Abnormal number of erythroid precursors (HP:0012131)4.15972758
12Rib fusion (HP:0000902)4.10512969
13Hepatic necrosis (HP:0002605)4.10009052
14Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.03745601
15Macrocytic anemia (HP:0001972)4.03193998
16Increased hepatocellular lipid droplets (HP:0006565)3.93314637
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.89732071
18Decreased activity of mitochondrial respiratory chain (HP:0008972)3.89732071
19Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.79857647
20Abnormality of the aortic arch (HP:0012303)3.75238379
21Exercise intolerance (HP:0003546)3.62953822
22Aplasia/Hypoplasia of the sacrum (HP:0008517)3.59314971
23Lipid accumulation in hepatocytes (HP:0006561)3.58175974
24Septo-optic dysplasia (HP:0100842)3.37688800
25Respiratory failure (HP:0002878)3.35450929
26Increased serum lactate (HP:0002151)3.30759199
27Pallor (HP:0000980)3.25412210
28Increased intramyocellular lipid droplets (HP:0012240)3.23840075
29Concave nail (HP:0001598)3.23288491
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.22689693
31Short 4th metacarpal (HP:0010044)3.22689693
32Exertional dyspnea (HP:0002875)3.19339963
33Stomatitis (HP:0010280)3.19041254
34Vitreoretinal degeneration (HP:0000655)3.18185137
35Abnormal hemoglobin (HP:0011902)3.17260938
36Myelomeningocele (HP:0002475)3.16332593
37Osteomalacia (HP:0002749)3.08564147
38Renal Fanconi syndrome (HP:0001994)3.05880964
39Abnormal pancreas size (HP:0012094)3.02572743
40Abnormality of glycolysis (HP:0004366)2.99863199
41Increased serum pyruvate (HP:0003542)2.99863199
42Sudden death (HP:0001699)2.97781786
43Ulnar deviation of the wrist (HP:0003049)2.97409528
44Breast hypoplasia (HP:0003187)2.93323312
45Optic disc pallor (HP:0000543)2.87040975
46Lactic acidosis (HP:0003128)2.85805239
47Cerebral edema (HP:0002181)2.84848082
48Increased muscle lipid content (HP:0009058)2.84288351
49Hepatoblastoma (HP:0002884)2.80137358
50Patent foramen ovale (HP:0001655)2.78653879
513-Methylglutaconic aciduria (HP:0003535)2.73587992
52Progressive external ophthalmoplegia (HP:0000590)2.71490890
53Ventricular tachycardia (HP:0004756)2.69302881
54Congenital, generalized hypertrichosis (HP:0004540)2.66748061
55Nausea (HP:0002018)2.63564163
56Meningocele (HP:0002435)2.57903971
57Anterior segment dysgenesis (HP:0007700)2.55809931
58Trismus (HP:0000211)2.54600726
59High anterior hairline (HP:0009890)2.54425551
60Retrobulbar optic neuritis (HP:0100654)2.54192445
61Optic neuritis (HP:0100653)2.54192445
62Muscle hypertrophy of the lower extremities (HP:0008968)2.53360854
63Double outlet right ventricle (HP:0001719)2.49933039
64Congenital malformation of the right heart (HP:0011723)2.49933039
65Leukodystrophy (HP:0002415)2.46490725
66Ridged nail (HP:0001807)2.46191925
67Abnormality of the 4th metacarpal (HP:0010012)2.44956655
68Orchitis (HP:0100796)2.43797219
69Episodic fever (HP:0001954)2.43726858
70Abnormality of macrophages (HP:0004311)2.41235624
71Abnormality of the fetal cardiovascular system (HP:0010948)2.39479275
72Abnormal umbilical cord blood vessels (HP:0011403)2.39479275
73Single umbilical artery (HP:0001195)2.39479275
74Anteriorly placed anus (HP:0001545)2.38303321
75Spontaneous hematomas (HP:0007420)2.37628151
76Hematochezia (HP:0002573)2.37108384
77Choanal stenosis (HP:0000452)2.28218385
78Microvesicular hepatic steatosis (HP:0001414)2.27951620
79Calf muscle hypertrophy (HP:0008981)2.27552350
80Respiratory difficulties (HP:0002880)2.26836052
81Triphalangeal thumb (HP:0001199)2.23357035
82Turricephaly (HP:0000262)2.20579124
83Growth hormone deficiency (HP:0000824)2.19712475
84Diastasis recti (HP:0001540)2.19007492
85Disproportionate short-trunk short stature (HP:0003521)2.15566827
86Cerebral hypomyelination (HP:0006808)2.14630826
87Heart block (HP:0012722)2.14058398
88Skull defect (HP:0001362)2.12393575
89Delayed epiphyseal ossification (HP:0002663)2.11091283
90Abnormal hair whorl (HP:0010721)2.10660912
91Anal stenosis (HP:0002025)2.10471419
92Stenosis of the external auditory canal (HP:0000402)2.10027613
93Aplasia/hypoplasia of the uterus (HP:0008684)2.09662675
94Broad thumb (HP:0011304)2.08662845
95Absent radius (HP:0003974)2.08227924
96Abdominal situs inversus (HP:0003363)2.08015280
97Abnormality of abdominal situs (HP:0011620)2.08015280
98Supernumerary spleens (HP:0009799)2.07572821
99Sclerocornea (HP:0000647)2.05757585
100Lipoatrophy (HP:0100578)2.05699720
101Increased IgM level (HP:0003496)2.05326890
102Partial duplication of thumb phalanx (HP:0009944)2.04066193
103Trigonocephaly (HP:0000243)2.04042550
104Occipital encephalocele (HP:0002085)2.03572842
105Porencephaly (HP:0002132)2.03422937
106Nonimmune hydrops fetalis (HP:0001790)2.01938477
107Annular pancreas (HP:0001734)2.01357718
108Supraventricular arrhythmia (HP:0005115)2.00804195
109Microretrognathia (HP:0000308)2.00793782
110Broad toe (HP:0001837)1.99320426
111Birth length less than 3rd percentile (HP:0003561)1.99013703
112Testicular atrophy (HP:0000029)1.98625791
113Choroideremia (HP:0001139)1.98446329
114Maternal diabetes (HP:0009800)1.98238204
115Abnormal lung lobation (HP:0002101)1.96510418
116Supraventricular tachycardia (HP:0004755)1.96249608
117Absent septum pellucidum (HP:0001331)1.95990741
118Redundant skin (HP:0001582)1.95798036
119Supernumerary ribs (HP:0005815)1.95754485
120Aplasia involving forearm bones (HP:0009822)1.95637166
121Absent forearm bone (HP:0003953)1.95637166
122Myotonia (HP:0002486)1.94255579
123Emotional lability (HP:0000712)1.94212284
124Rectovaginal fistula (HP:0000143)1.94143781
125Rectal fistula (HP:0100590)1.94143781
126Asymmetric septal hypertrophy (HP:0001670)1.92562914
127Muscle fiber inclusion bodies (HP:0100299)1.91505576
128Pulmonary artery stenosis (HP:0004415)1.89201727
129Congenital diaphragmatic hernia (HP:0000776)1.88963917
130Myopathic facies (HP:0002058)1.88862354
131Midline defect of the nose (HP:0004122)1.88475123
132Abnormality of the nasal septum (HP:0000419)1.87611246
133Nasal speech (HP:0001611)1.86480117
134Severe Myopia (HP:0011003)1.86418063
135Atrial fibrillation (HP:0005110)1.86163653
136Enlarged kidneys (HP:0000105)1.85398727
137Bifid tongue (HP:0010297)1.85222489
138Eczematoid dermatitis (HP:0000976)1.85059315
139Myositis (HP:0100614)1.84853468
140Horseshoe kidney (HP:0000085)1.84487244
141Hyperphosphaturia (HP:0003109)1.84035591
142Type I transferrin isoform profile (HP:0003642)1.83934977
143Adactyly (HP:0009776)1.83408766
144Asplenia (HP:0001746)1.83056131
145Supernumerary bones of the axial skeleton (HP:0009144)1.82721097
146Ragged-red muscle fibers (HP:0003200)1.82605812
147Muscle fiber splitting (HP:0003555)1.82437457
148Primary atrial arrhythmia (HP:0001692)1.81515596
149Asymmetry of the thorax (HP:0001555)1.81299326
150Capillary hemangiomas (HP:0005306)1.80947120
151Atrioventricular block (HP:0001678)1.80215283
152Broad hallux (HP:0010055)1.79421248
153Oral leukoplakia (HP:0002745)1.79290011
154Carpal bone hypoplasia (HP:0001498)1.79170080
155Abnormality of renal resorption (HP:0011038)1.79034629
156Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.78817207
157Hydroureter (HP:0000072)1.78326508
158Aplasia/Hypoplasia of the spleen (HP:0010451)1.78077105
159Absent eyelashes (HP:0000561)1.77974102
160Dilated cardiomyopathy (HP:0001644)1.77809858
161Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.77020611
162CNS demyelination (HP:0007305)1.75263213
163Abnormal ventriculo-arterial connection (HP:0011563)1.75160840
164Transposition of the great arteries (HP:0001669)1.75160840
165Abnormal connection of the cardiac segments (HP:0011545)1.75160840
166Polyphagia (HP:0002591)1.74902177
167Keratoconjunctivitis sicca (HP:0001097)1.74885332
168Amyloidosis (HP:0011034)1.74295877
169Prolonged bleeding time (HP:0003010)1.74117660
170Hypoplastic left heart (HP:0004383)1.74086767
171Rhabdomyolysis (HP:0003201)1.72561282
172Progressive muscle weakness (HP:0003323)1.72405092
173Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71909670
174Lymphangioma (HP:0100764)1.71787243
175Adrenal hypoplasia (HP:0000835)1.70418071
176Keratoconjunctivitis (HP:0001096)1.70347146
177Abnormal atrioventricular conduction (HP:0005150)1.70300508
178Absent hand (HP:0004050)1.69839290
179Renal hypoplasia (HP:0000089)1.68663714
180Aplasia/Hypoplasia involving the musculature (HP:0001460)1.68058540
181Intestinal fistula (HP:0100819)1.66184312
182Partial duplication of the phalanx of hand (HP:0009999)1.65968919
183Anencephaly (HP:0002323)1.64715961
184Left ventricular hypertrophy (HP:0001712)1.64447210
185Cervical subluxation (HP:0003308)1.64060067
186Broad phalanges of the hand (HP:0009768)1.62068019
187Agitation (HP:0000713)1.61743141
188Vaginal fistula (HP:0004320)1.61522614
189Abnormality of the right ventricle (HP:0001707)1.61015429
190Peritonitis (HP:0002586)1.59102669
191Hypoplasia of the ulna (HP:0003022)1.58222155
192Oligodactyly (HP:0012165)1.57584637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR6.26048507
2TIE15.87619325
3TLK15.70295968
4BUB13.14413030
5NME22.72787523
6STK162.40596607
7EIF2AK12.22686358
8WEE12.05416611
9TYRO31.98032035
10MYLK1.88024189
11MKNK21.83770793
12EPHB21.83697644
13SRPK11.82822432
14OBSCN1.76794992
15VRK11.75297212
16CASK1.71608288
17SIK31.63523921
18GRK11.61459505
19TESK21.60602250
20NME11.60373403
21MAP3K111.59784729
22PBK1.53849637
23CSK1.43923417
24IRAK41.41510650
25MKNK11.40413308
26TGFBR11.39241254
27PLK41.35930185
28TSSK61.34784146
29WNK31.34601405
30LIMK11.32957960
31MAP2K41.31913085
32MARK21.29451664
33MAP4K11.26770899
34MATK1.26635831
35AKT31.18639591
36CDK191.10712115
37PRKD31.10584641
38BCR1.10547941
39DYRK1B1.09083473
40CDK81.08958144
41FGR1.08428499
42CHUK1.06750343
43RIPK11.01490791
44ZAP700.99447363
45NUAK10.95010651
46DAPK30.94888652
47AURKA0.93988822
48TNK20.93683780
49MAP3K60.93036313
50PRKD20.92404057
51PTK2B0.92378890
52TXK0.91577035
53BRAF0.90963661
54BCKDK0.90848496
55ILK0.89531527
56CDK70.88876943
57ZAK0.85302252
58TGFBR20.84886686
59PIM20.84028148
60NLK0.83290142
61DYRK30.82979391
62DYRK20.82142514
63MAP3K70.80494137
64TAOK10.80370987
65DDR20.80350347
66MST40.79955126
67PLK10.79404478
68STK38L0.79349124
69IKBKB0.78029907
70SIK20.77618831
71GRK60.77049055
72CAMK10.76309141
73KSR10.76190190
74TESK10.75371506
75STK110.74029529
76LRRK20.73668892
77PRKD10.73258066
78RIPK40.70304255
79BTK0.69039018
80FGFR20.68482619
81CLK10.67093526
82STK390.66927248
83ERBB20.65466848
84MARK30.65280501
85AURKB0.63102555
86BLK0.62631733
87MAPK70.61040446
88TYK20.60715145
89EPHA40.60369984
90CSNK2A10.59674426
91PINK10.59268883
92MAP3K50.58455981
93YES10.58444799
94TEC0.57435853
95PDK20.55780815
96IRAK10.55571550
97PTK60.55467855
98CAMK40.55194095
99EPHB10.54968729
100MAP3K30.54919045
101TTK0.54773755
102MAP2K20.54431903
103HCK0.53865897
104PRKG20.53780949
105TTN0.53208650
106ACVR1B0.52807905
107EIF2AK30.50916944
108MAP2K70.50518747
109NEK90.50286438
110PRKAA20.50083956
111IRAK30.47932258
112IKBKE0.47211282
113CAMK2D0.46152606
114CDC70.46133979
115ROCK20.46016884
116LATS20.45724189
117CDC42BPA0.44984750
118TNIK0.44162419
119GRK70.43799651
120ITK0.42886313
121CSNK2A20.42685011
122PLK20.42654291
123MAP3K140.42036586
124PAK10.41577484
125EPHA20.41343165
126EIF2AK20.39758183
127PNCK0.39395771
128BMPR1B0.38954464
129SGK2230.38568224
130SGK4940.38568224
131PIK3CA0.38144700
132MAPK150.38081199
133MAP3K10.37238304
134FES0.36922607
135RPS6KL10.36820571
136RPS6KC10.36820571
137LYN0.36611585
138MAP2K30.36170002
139PAK40.36110633
140MAP3K40.36014208
141RPS6KA50.35537474
142IRAK20.35352004
143FER0.35108857
144PRKCZ0.34872464
145DMPK0.34861458
146CAMK1D0.34570898
147SIK10.34174346
148ABL20.33988323
149TAOK20.33255083
150MAPK120.33089739
151PAK30.32622453
152RPS6KA60.32608863
153RPS6KA20.31914230
154PRKCI0.31711384
155AKT20.31449520
156CAMK2B0.27068030
157PLK30.26510306
158UHMK10.26162899
159RPS6KB20.26097734
160ADRBK20.25336431
161ROCK10.24962139
162MAP3K120.24323419
163STK240.24242276
164MAP3K80.24136545
165CAMK2G0.23615044
166STK40.23438394
167WNK40.23220900

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.24592229
2Oxidative phosphorylation_Homo sapiens_hsa001904.31267230
3RNA polymerase_Homo sapiens_hsa030204.00302539
4Proteasome_Homo sapiens_hsa030503.92282608
5Parkinsons disease_Homo sapiens_hsa050123.89235855
6Huntingtons disease_Homo sapiens_hsa050163.03514724
7DNA replication_Homo sapiens_hsa030303.00385267
8Protein export_Homo sapiens_hsa030603.00073710
9Spliceosome_Homo sapiens_hsa030402.80015541
10Alzheimers disease_Homo sapiens_hsa050102.69379446
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.65630189
12Mismatch repair_Homo sapiens_hsa034302.57360002
13Malaria_Homo sapiens_hsa051442.53091640
14NOD-like receptor signaling pathway_Homo sapiens_hsa046212.50221459
15Homologous recombination_Homo sapiens_hsa034402.36944438
16Pyrimidine metabolism_Homo sapiens_hsa002402.35481488
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.31858303
18Osteoclast differentiation_Homo sapiens_hsa043802.23588009
19Cardiac muscle contraction_Homo sapiens_hsa042602.19444216
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.03640612
21Nucleotide excision repair_Homo sapiens_hsa034201.96888528
22Base excision repair_Homo sapiens_hsa034101.74714885
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.65533584
24RNA transport_Homo sapiens_hsa030131.63460589
25Basal transcription factors_Homo sapiens_hsa030221.62967282
26Salmonella infection_Homo sapiens_hsa051321.60042613
27TNF signaling pathway_Homo sapiens_hsa046681.56946636
28Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.51696442
29Purine metabolism_Homo sapiens_hsa002301.42196437
30VEGF signaling pathway_Homo sapiens_hsa043701.39741464
31Fanconi anemia pathway_Homo sapiens_hsa034601.37391085
32Amoebiasis_Homo sapiens_hsa051461.32909284
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.32299359
34Chemokine signaling pathway_Homo sapiens_hsa040621.30134431
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.26825434
36NF-kappa B signaling pathway_Homo sapiens_hsa040641.25938676
37RNA degradation_Homo sapiens_hsa030181.23994838
38AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.23611726
39Legionellosis_Homo sapiens_hsa051341.22975962
40RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20754827
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20449687
42Cell cycle_Homo sapiens_hsa041101.15648487
43Pertussis_Homo sapiens_hsa051331.13202755
44Basal cell carcinoma_Homo sapiens_hsa052171.12856325
45Leishmaniasis_Homo sapiens_hsa051401.10037789
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.09070249
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07093228
48One carbon pool by folate_Homo sapiens_hsa006701.03025506
49Tuberculosis_Homo sapiens_hsa051520.99791783
50Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.97956553
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.97478398
52Acute myeloid leukemia_Homo sapiens_hsa052210.95447065
53Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90752358
54MAPK signaling pathway_Homo sapiens_hsa040100.89686320
55Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89456178
56African trypanosomiasis_Homo sapiens_hsa051430.89433800
57Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88406151
58FoxO signaling pathway_Homo sapiens_hsa040680.87785960
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86240115
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85875587
61Sulfur relay system_Homo sapiens_hsa041220.84998286
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83673342
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.81806688
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.81665895
65cAMP signaling pathway_Homo sapiens_hsa040240.81349645
66Shigellosis_Homo sapiens_hsa051310.76889578
67Epstein-Barr virus infection_Homo sapiens_hsa051690.75883542
68mRNA surveillance pathway_Homo sapiens_hsa030150.75443640
69Platelet activation_Homo sapiens_hsa046110.74827615
70Non-homologous end-joining_Homo sapiens_hsa034500.74004566
71Endometrial cancer_Homo sapiens_hsa052130.73434048
72Tight junction_Homo sapiens_hsa045300.72443791
73Rheumatoid arthritis_Homo sapiens_hsa053230.72069535
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71859892
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.69922861
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.69184550
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68696735
78Staphylococcus aureus infection_Homo sapiens_hsa051500.68154402
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67108604
80Hedgehog signaling pathway_Homo sapiens_hsa043400.66533593
81Colorectal cancer_Homo sapiens_hsa052100.66157879
82Collecting duct acid secretion_Homo sapiens_hsa049660.65426586
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63982219
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.61468493
85Hippo signaling pathway_Homo sapiens_hsa043900.61415362
86Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.61253562
87Steroid biosynthesis_Homo sapiens_hsa001000.60850739
88Dilated cardiomyopathy_Homo sapiens_hsa054140.59758721
89B cell receptor signaling pathway_Homo sapiens_hsa046620.59140526
90Insulin resistance_Homo sapiens_hsa049310.59042662
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.59021242
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58926676
93Folate biosynthesis_Homo sapiens_hsa007900.58361462
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57796344
95Phospholipase D signaling pathway_Homo sapiens_hsa040720.56504445
96Fatty acid elongation_Homo sapiens_hsa000620.55600591
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54821775
98Endocytosis_Homo sapiens_hsa041440.54289644
99Metabolic pathways_Homo sapiens_hsa011000.54283284
100Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.54155700
101Melanogenesis_Homo sapiens_hsa049160.53211393
102Oocyte meiosis_Homo sapiens_hsa041140.52064078
103Wnt signaling pathway_Homo sapiens_hsa043100.51814408
104Phototransduction_Homo sapiens_hsa047440.51674072
105Oxytocin signaling pathway_Homo sapiens_hsa049210.51610763
106Hepatitis C_Homo sapiens_hsa051600.50256555
107Hepatitis B_Homo sapiens_hsa051610.49789300
108Vibrio cholerae infection_Homo sapiens_hsa051100.49404472
109TGF-beta signaling pathway_Homo sapiens_hsa043500.49096576
110Renal cell carcinoma_Homo sapiens_hsa052110.48943743
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48735546
112Lysosome_Homo sapiens_hsa041420.48599630
113p53 signaling pathway_Homo sapiens_hsa041150.47791000
114Thyroid cancer_Homo sapiens_hsa052160.46124625
115Prolactin signaling pathway_Homo sapiens_hsa049170.45993018
116HTLV-I infection_Homo sapiens_hsa051660.45522894
117Morphine addiction_Homo sapiens_hsa050320.45483708
118Proteoglycans in cancer_Homo sapiens_hsa052050.45207392
119Arginine and proline metabolism_Homo sapiens_hsa003300.44370270
120HIF-1 signaling pathway_Homo sapiens_hsa040660.44256152
121Carbon metabolism_Homo sapiens_hsa012000.43623039
122Glutathione metabolism_Homo sapiens_hsa004800.43487350
123Galactose metabolism_Homo sapiens_hsa000520.42990735
124Insulin signaling pathway_Homo sapiens_hsa049100.42290100
125Prostate cancer_Homo sapiens_hsa052150.41667056
126Arachidonic acid metabolism_Homo sapiens_hsa005900.41343747
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.40624617
128PI3K-Akt signaling pathway_Homo sapiens_hsa041510.38059966
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.37241446
130Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.36264490
131Leukocyte transendothelial migration_Homo sapiens_hsa046700.35636636
132Systemic lupus erythematosus_Homo sapiens_hsa053220.34190992
133Pathways in cancer_Homo sapiens_hsa052000.32839689
134Rap1 signaling pathway_Homo sapiens_hsa040150.32644855
135Adherens junction_Homo sapiens_hsa045200.31324016
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31003503
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29921001
138Notch signaling pathway_Homo sapiens_hsa043300.27921146
139Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.27477147
140Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27144405
141Sphingolipid metabolism_Homo sapiens_hsa006000.26406497
142Axon guidance_Homo sapiens_hsa043600.25586341
143Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.23426302
144Pyruvate metabolism_Homo sapiens_hsa006200.22306037
145Bladder cancer_Homo sapiens_hsa052190.22055878
146Melanoma_Homo sapiens_hsa052180.20243870
147Alcoholism_Homo sapiens_hsa050340.19536016
148Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.19394270
149ECM-receptor interaction_Homo sapiens_hsa045120.18829777
150Propanoate metabolism_Homo sapiens_hsa006400.16802364
151Viral myocarditis_Homo sapiens_hsa054160.16266050
152Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15481370
153Ras signaling pathway_Homo sapiens_hsa040140.15452737
154Biosynthesis of amino acids_Homo sapiens_hsa012300.15228291
155Hematopoietic cell lineage_Homo sapiens_hsa046400.14781537
156Vascular smooth muscle contraction_Homo sapiens_hsa042700.12610716
157Focal adhesion_Homo sapiens_hsa045100.12395726
158Herpes simplex infection_Homo sapiens_hsa051680.12335847
159Cysteine and methionine metabolism_Homo sapiens_hsa002700.09814710
160Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09585939
161Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08810769
162Pentose phosphate pathway_Homo sapiens_hsa000300.07700769
163Tyrosine metabolism_Homo sapiens_hsa003500.05661201

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