TMEM81

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.13029754
2myelin maintenance (GO:0043217)7.05355161
3protein localization to endosome (GO:0036010)6.93258327
4ensheathment of neurons (GO:0007272)6.63296418
5axon ensheathment (GO:0008366)6.63296418
6myelination (GO:0042552)6.43081706
7membrane tubulation (GO:0097320)5.49558592
8erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.25674450
9L-phenylalanine catabolic process (GO:0006559)5.25674450
10negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)5.22072165
11negative regulation of inclusion body assembly (GO:0090084)5.05341237
12creatine metabolic process (GO:0006600)5.03917411
13behavioral response to nicotine (GO:0035095)4.96201794
14pyrimidine nucleobase catabolic process (GO:0006208)4.88719555
15mitochondrion transport along microtubule (GO:0047497)4.86565826
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.86565826
17long-chain fatty acid biosynthetic process (GO:0042759)4.62353780
18erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.59218380
19L-phenylalanine metabolic process (GO:0006558)4.59218380
20viral transcription (GO:0019083)4.55367506
21long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.43213636
22cholesterol biosynthetic process (GO:0006695)4.38991539
23translational termination (GO:0006415)4.38347110
24maturation of SSU-rRNA (GO:0030490)4.36508813
25nonmotile primary cilium assembly (GO:0035058)4.35113522
26chaperone-mediated protein transport (GO:0072321)4.32639614
27establishment of protein localization to mitochondrial membrane (GO:0090151)4.30065248
28regulation of feeding behavior (GO:0060259)4.28833328
29DNA replication checkpoint (GO:0000076)4.28590814
30fatty-acyl-CoA biosynthetic process (GO:0046949)4.23602334
31establishment of mitochondrion localization (GO:0051654)4.21691827
32negative regulation of neurotransmitter secretion (GO:0046929)4.18943134
33ribosomal small subunit biogenesis (GO:0042274)4.14834598
34ribosomal small subunit assembly (GO:0000028)4.12529170
35negative regulation of neurotransmitter transport (GO:0051589)4.12421494
36mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.12304857
37amyloid precursor protein metabolic process (GO:0042982)4.10210124
38forebrain neuron differentiation (GO:0021879)4.08662292
39long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.89818042
40oligodendrocyte differentiation (GO:0048709)3.85309336
41ATP synthesis coupled proton transport (GO:0015986)3.83184818
42energy coupled proton transport, down electrochemical gradient (GO:0015985)3.83184818
43kinetochore organization (GO:0051383)3.82567288
44heart field specification (GO:0003128)3.82425455
45secondary heart field specification (GO:0003139)3.82425455
46heme transport (GO:0015886)3.78733807
47astrocyte development (GO:0014002)3.78378385
48response to methylmercury (GO:0051597)3.77990680
49positive regulation of mitochondrial calcium ion concentration (GO:0051561)3.77770625
50sterol biosynthetic process (GO:0016126)3.77470730
51L-serine metabolic process (GO:0006563)3.74612392
52specification of organ identity (GO:0010092)3.69327763
53fatty-acyl-CoA metabolic process (GO:0035337)3.69039865
54response to lipoprotein particle (GO:0055094)3.68149007
55regulation of collateral sprouting (GO:0048670)3.66473391
56myelination in peripheral nervous system (GO:0022011)3.63218346
57peripheral nervous system axon ensheathment (GO:0032292)3.63218346
58cotranslational protein targeting to membrane (GO:0006613)3.59555493
59regulation of lipoprotein metabolic process (GO:0050746)3.57698450
60protein targeting to ER (GO:0045047)3.56576798
61amyloid precursor protein catabolic process (GO:0042987)3.55147085
62translational elongation (GO:0006414)3.54273207
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.53718097
64viral life cycle (GO:0019058)3.52460637
65cellular protein complex disassembly (GO:0043624)3.49787112
66nucleobase catabolic process (GO:0046113)3.49010580
67tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.48585649
68RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.48585649
69ribosomal large subunit biogenesis (GO:0042273)3.46999690
70protein localization to kinetochore (GO:0034501)3.46946242
71very long-chain fatty acid metabolic process (GO:0000038)3.46478126
72pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.44010960
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.43456919
74nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.43445292
75regulation of DNA endoreduplication (GO:0032875)3.40779754
76acyl-CoA biosynthetic process (GO:0071616)3.40254698
77thioester biosynthetic process (GO:0035384)3.40254698
78neurofilament cytoskeleton organization (GO:0060052)3.38894599
79protein localization to endoplasmic reticulum (GO:0070972)3.37823222
80L-amino acid import (GO:0043092)3.36400858
81negative regulation of viral release from host cell (GO:1902187)3.35874360
82mitotic chromosome condensation (GO:0007076)3.32022537
83meiotic chromosome segregation (GO:0045132)3.30496673
84protein complex disassembly (GO:0043241)3.27865352
85asymmetric protein localization (GO:0008105)3.22292697
86regulation of penile erection (GO:0060405)3.20682842
87resolution of meiotic recombination intermediates (GO:0000712)3.18166071
88substrate-independent telencephalic tangential migration (GO:0021826)3.18148848
89substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.18148848
90microtubule polymerization or depolymerization (GO:0031109)3.18056716
91positive regulation of oligodendrocyte differentiation (GO:0048714)3.17494206
92import into cell (GO:0098657)3.16396581
93negative regulation of DNA-dependent DNA replication (GO:2000104)3.16250330
94pyrimidine nucleotide catabolic process (GO:0006244)3.15869475
95macromolecular complex disassembly (GO:0032984)3.15396863
96endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.15017565
97chaperone-mediated protein complex assembly (GO:0051131)3.13816729
98axonal fasciculation (GO:0007413)3.12897925
99kinetochore assembly (GO:0051382)3.12018519
100single strand break repair (GO:0000012)3.11221845
101iron coordination entity transport (GO:1901678)3.11050613
102axon development (GO:0061564)3.09763740
103membrane raft organization (GO:0031579)3.09175496
104replication fork processing (GO:0031297)3.09041381
105transcription elongation from RNA polymerase III promoter (GO:0006385)3.08327489
106termination of RNA polymerase III transcription (GO:0006386)3.08327489
107chromatin remodeling at centromere (GO:0031055)3.07909061
108apical protein localization (GO:0045176)3.06515511
109base-excision repair, AP site formation (GO:0006285)3.06204308
110neuron recognition (GO:0008038)3.04490958
111negative regulation of macroautophagy (GO:0016242)3.02980140
112translational initiation (GO:0006413)3.02674239
113isoprenoid biosynthetic process (GO:0008299)3.00651188
114cortical actin cytoskeleton organization (GO:0030866)3.00512093
115regulation of ARF GTPase activity (GO:0032312)2.97676490
116protein localization to cilium (GO:0061512)2.95533689
117negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.95441204
118DNA replication-independent nucleosome organization (GO:0034724)2.94566933
119DNA replication-independent nucleosome assembly (GO:0006336)2.94566933
120lipid translocation (GO:0034204)2.94499049
121phospholipid translocation (GO:0045332)2.94499049
122positive regulation of gamma-delta T cell activation (GO:0046645)2.93541711
123ventricular trabecula myocardium morphogenesis (GO:0003222)2.89216902
124substantia nigra development (GO:0021762)2.88854809
125DNA strand renaturation (GO:0000733)2.85262208
126ganglion development (GO:0061548)2.84308103
127protein localization to chromosome, centromeric region (GO:0071459)2.84292887
128histone exchange (GO:0043486)2.84208874
129ribonucleoprotein complex biogenesis (GO:0022613)2.83124572
130negative regulation of GTPase activity (GO:0034260)2.80645712
131negative regulation of GTP catabolic process (GO:0033125)2.80645712
132enteric nervous system development (GO:0048484)2.79870274
133positive regulation of cellular amine metabolic process (GO:0033240)2.79332649
134regulation of interleukin-13 production (GO:0032656)2.79030464
135negative regulation of response to reactive oxygen species (GO:1901032)2.78205422
136aspartate family amino acid catabolic process (GO:0009068)2.76667538
137negative regulation of DNA recombination (GO:0045910)2.74710297
138centrosome localization (GO:0051642)2.74169912
139nuclear-transcribed mRNA catabolic process (GO:0000956)2.74085596
140serine family amino acid biosynthetic process (GO:0009070)2.73792613
141pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.73459402
142regulation of inclusion body assembly (GO:0090083)2.72022158
143negative regulation of acute inflammatory response (GO:0002674)2.71040165
144pattern specification involved in kidney development (GO:0061004)2.71000606
145synapsis (GO:0007129)2.70860968
146ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.69986569
147maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69787223
148mRNA splice site selection (GO:0006376)2.68268439
149cofactor catabolic process (GO:0051187)2.68078372
150response to lead ion (GO:0010288)2.67468844
151negative regulation of telomere maintenance (GO:0032205)2.66808272
152aromatic amino acid family catabolic process (GO:0009074)2.66305707
153negative regulation of protein localization to cell surface (GO:2000009)2.66226779
154regulation of gamma-delta T cell differentiation (GO:0045586)2.64534413
155regulation of viral release from host cell (GO:1902186)2.64457644
156somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64353133
157somatic hypermutation of immunoglobulin genes (GO:0016446)2.64353133
158detection of temperature stimulus involved in sensory perception (GO:0050961)2.63381795
159detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.63381795
160membrane protein ectodomain proteolysis (GO:0006509)2.63207207
161CENP-A containing nucleosome assembly (GO:0034080)2.62230645
162mitotic sister chromatid segregation (GO:0000070)2.61230097
163mRNA catabolic process (GO:0006402)2.60694358
164pyrimidine dimer repair (GO:0006290)2.59940719
165exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.59233640
166mitotic spindle organization (GO:0007052)2.59091193
167regulation of telomere maintenance (GO:0032204)2.58720353
168glycerophospholipid catabolic process (GO:0046475)2.58605786
169positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.57275362
170establishment of monopolar cell polarity (GO:0061162)2.57157928
171establishment or maintenance of monopolar cell polarity (GO:0061339)2.57157928
172presynaptic membrane assembly (GO:0097105)2.57023986
173negative regulation of appetite (GO:0032099)2.56974400
174negative regulation of response to food (GO:0032096)2.56974400
175cerebral cortex radially oriented cell migration (GO:0021799)2.56772657
176leukocyte migration involved in inflammatory response (GO:0002523)2.56646054
177fusion of sperm to egg plasma membrane (GO:0007342)2.56504156
178cortical cytoskeleton organization (GO:0030865)2.56428661
179negative regulation of receptor-mediated endocytosis (GO:0048261)2.55957494
180negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.55008748
181protein palmitoylation (GO:0018345)2.54548192
182nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54413660
183organ growth (GO:0035265)2.53991360
184cellular component biogenesis (GO:0044085)2.53916725
185RNA catabolic process (GO:0006401)2.53750013
186leukocyte aggregation (GO:0070486)2.50306002
187peptidyl-cysteine modification (GO:0018198)2.46858627
188regulation of lamellipodium assembly (GO:0010591)2.44025755
189mitochondrion degradation (GO:0000422)2.43816381
190cholesterol metabolic process (GO:0008203)2.43155972
191fucose catabolic process (GO:0019317)2.40955461
192L-fucose metabolic process (GO:0042354)2.40955461
193L-fucose catabolic process (GO:0042355)2.40955461
194regulation of hydrogen peroxide-induced cell death (GO:1903205)2.40014121
195neuron remodeling (GO:0016322)2.39013780
196Leydig cell differentiation (GO:0033327)2.38152299
197axon ensheathment in central nervous system (GO:0032291)12.8551798
198central nervous system myelination (GO:0022010)12.8551798

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat6.00779928
2E2F7_22180533_ChIP-Seq_HELA_Human4.96273589
3EZH2_22144423_ChIP-Seq_EOC_Human4.76643734
4STAT6_21828071_ChIP-Seq_BEAS2B_Human4.64801754
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.33800594
6RBPJ_22232070_ChIP-Seq_NCS_Mouse4.11736440
7E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.84922383
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66353677
9VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human3.55809302
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.36412146
11VDR_21846776_ChIP-Seq_THP-1_Human3.09102927
12EST1_17652178_ChIP-ChIP_JURKAT_Human3.01760618
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95940667
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.80620154
15FOXM1_23109430_ChIP-Seq_U2OS_Human2.76218515
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.73230004
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.70627915
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.62287365
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.59724885
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.52074786
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.47727376
22E2F4_17652178_ChIP-ChIP_JURKAT_Human2.35072776
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.31299086
24JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30618820
25RUNX_20019798_ChIP-Seq_JUKART_Human2.21901805
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19763149
27HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.19021729
28SCL_19346495_ChIP-Seq_HPC-7_Human2.18683534
29THAP11_20581084_ChIP-Seq_MESCs_Mouse2.15779982
30XRN2_22483619_ChIP-Seq_HELA_Human2.12509284
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.10670817
32IRF8_27001747_Chip-Seq_BMDM_Mouse2.08853806
33YY1_21170310_ChIP-Seq_MESCs_Mouse2.05114629
34TTF2_22483619_ChIP-Seq_HELA_Human1.99974823
35RXR_22158963_ChIP-Seq_LIVER_Mouse1.98238222
36ELK1_19687146_ChIP-ChIP_HELA_Human1.98090711
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.96484703
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94964035
39SALL1_21062744_ChIP-ChIP_HESCs_Human1.93769630
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.91362767
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88476408
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.88098027
43GABP_19822575_ChIP-Seq_HepG2_Human1.84833408
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.84248037
45FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.82536362
46VDR_24763502_ChIP-Seq_THP-1_Human1.82388920
47MYB_26560356_Chip-Seq_TH2_Human1.81024805
48NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79654433
49STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.77711984
50IRF8_21731497_ChIP-ChIP_J774_Mouse1.76816576
51GATA1_19941826_ChIP-Seq_K562_Human1.76288771
52UTX_26944678_Chip-Seq_JUKART_Human1.76021283
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.75890619
54IRF8_22096565_ChIP-ChIP_GC-B_Human1.74035312
55PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.73286274
56FOXO3_23340844_ChIP-Seq_DLD1_Human1.72582306
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72515556
58KDM2B_26808549_Chip-Seq_DND41_Human1.69377890
59IRF1_19129219_ChIP-ChIP_H3396_Human1.68848306
60STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66249456
61SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64767058
62PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.64390030
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.62871121
64MAF_26560356_Chip-Seq_TH1_Human1.62175367
65VDR_23849224_ChIP-Seq_CD4+_Human1.61466151
66MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60889203
67RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.58634400
68KDM5A_27292631_Chip-Seq_BREAST_Human1.58537932
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.57707375
70FOXP3_21729870_ChIP-Seq_TREG_Human1.55712235
71REST_21632747_ChIP-Seq_MESCs_Mouse1.54711320
72MYB_26560356_Chip-Seq_TH1_Human1.52201735
73KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51626202
74GATA3_27048872_Chip-Seq_THYMUS_Human1.50747227
75MYC_19030024_ChIP-ChIP_MESCs_Mouse1.49792976
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48978691
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48702196
78PPARA_22158963_ChIP-Seq_LIVER_Mouse1.48555542
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48215330
80NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.46803904
81GATA1_22383799_ChIP-Seq_G1ME_Mouse1.45494727
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45056816
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.44061874
84MAF_26560356_Chip-Seq_TH2_Human1.42955817
85RUNX1_22412390_ChIP-Seq_EML_Mouse1.40489435
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.38726861
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.38481317
88PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.36567709
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35817359
90MYC_22102868_ChIP-Seq_BL_Human1.35463234
91RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.35240226
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.35208964
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.35194312
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.34717961
95BRD4_27068464_Chip-Seq_AML-cells_Mouse1.33607250
96MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.33575289
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31277773
98POU5F1_16153702_ChIP-ChIP_HESCs_Human1.30735482
99GATA1_19941827_ChIP-Seq_MEL86_Mouse1.29680376
100MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29523389
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.28554105
102EGR1_23403033_ChIP-Seq_LIVER_Mouse1.28192658
103CIITA_25753668_ChIP-Seq_RAJI_Human1.28150786
104MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27212982
105E2F1_21310950_ChIP-Seq_MCF-7_Human1.26823254
106STAT4_19710469_ChIP-ChIP_TH1__Mouse1.26393713
107CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.24598046
108SPI1_23127762_ChIP-Seq_K562_Human1.23340600
109SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23163866
110FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.22113049
111E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21665559
112GATA1_26923725_Chip-Seq_HPCs_Mouse1.19925238
113CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19827515
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.19279622
115STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.18491582
116* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17093450
117TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.17081749
118SOX2_27498859_Chip-Seq_STOMACH_Mouse1.15595160
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15122301
120CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.13402414
121PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.13049426
122HTT_18923047_ChIP-ChIP_STHdh_Human1.12793326
123E2F1_18555785_ChIP-Seq_MESCs_Mouse1.12641140
124SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12096410
125HOXB4_20404135_ChIP-ChIP_EML_Mouse1.11998500
126TP53_22127205_ChIP-Seq_IMR90_Human1.10676881
127ELK3_25401928_ChIP-Seq_HUVEC_Human1.09620285
128SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08643728
129CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08387389
130TCF7_22412390_ChIP-Seq_EML_Mouse1.08149275
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07334172
132IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07333990
133SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.06412305
134VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.05037537
135DCP1A_22483619_ChIP-Seq_HELA_Human1.04441638
136NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.02835403
137KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02686696
138NOTCH1_21737748_ChIP-Seq_TLL_Human1.02588031
139CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.01730873
140GATA3_26560356_Chip-Seq_TH1_Human1.00930861
141MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99638990
142ETV2_25802403_ChIP-Seq_MESCs_Mouse0.99409265
143LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99211767
144PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97808704
145SRF_21415370_ChIP-Seq_HL-1_Mouse0.97567309
146PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96728920
147GATA2_19941826_ChIP-Seq_K562_Human0.96293379
148SA1_27219007_Chip-Seq_Bcells_Human0.95513769
149FOXP1_21924763_ChIP-Seq_HESCs_Human0.93111203
150IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93025605
151YY1_22570637_ChIP-Seq_MALME-3M_Human0.92342657
152HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.91728577
153P53_22127205_ChIP-Seq_FIBROBLAST_Human0.91516112
154TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91288724
155POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91288724
156FOXA2_19822575_ChIP-Seq_HepG2_Human0.91257999
157RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91191821
158SPI1_20517297_ChIP-Seq_HL60_Human0.87927140
159NANOG_18555785_ChIP-Seq_MESCs_Mouse0.87401727
160ZNF274_21170338_ChIP-Seq_K562_Hela0.87181562
161CTCF_21964334_ChIP-Seq_BJAB-B_Human0.87065582
162CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.86713249
163CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.86664495
164KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.86403065
165KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.86403065
166KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.86403065
167EOMES_21245162_ChIP-Seq_HESCs_Human0.85992382
168REST_19997604_ChIP-ChIP_NEURONS_Mouse0.85800297
169KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.85057865
170DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84684234
171SOX2_18555785_ChIP-Seq_MESCs_Mouse0.84452015
172DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84401676
173GATA2_22383799_ChIP-Seq_G1ME_Mouse0.84113727
174ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83925093
175CBX2_27304074_Chip-Seq_ESCs_Mouse0.83477589
176TP53_22573176_ChIP-Seq_HFKS_Human0.83476805
177GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82905172
178P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82011797
179NCOR1_26117541_ChIP-Seq_K562_Human0.81911913
180PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.81582420
181GATA3_26560356_Chip-Seq_TH2_Human0.81361106
182CTCF_27219007_Chip-Seq_ERYTHROID_Human0.81355743
183MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79377273
184GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.79374295
185IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.79046952
186FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78829430
187* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78804979
188ZFX_18555785_ChIP-Seq_MESCs_Mouse0.78320898
189CTNNB1_20460455_ChIP-Seq_HCT116_Human0.78319925
190CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77758044
191PADI4_21655091_ChIP-ChIP_MCF-7_Human0.77467001
192RNF2_27304074_Chip-Seq_NSC_Mouse0.76401436
193SRY_22984422_ChIP-ChIP_TESTIS_Rat0.75647904
194HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75632875
195ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.74538472

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.71886342
2MP0002822_catalepsy4.70399911
3MP0005410_abnormal_fertilization4.19443539
4MP0005423_abnormal_somatic_nervous3.97252622
5MP0003122_maternal_imprinting3.68809101
6MP0002653_abnormal_ependyma_morphology3.59163802
7MP0003690_abnormal_glial_cell3.44222885
8MP0003950_abnormal_plasma_membrane3.39611836
9MP0006292_abnormal_olfactory_placode3.09565044
10MP0003941_abnormal_skin_development2.86548301
11MP0003121_genomic_imprinting2.70264149
12MP0000778_abnormal_nervous_system2.66556415
13MP0004381_abnormal_hair_follicle2.65401503
14MP0004859_abnormal_synaptic_plasticity2.64476302
15MP0005171_absent_coat_pigmentation2.62258177
16MP0003123_paternal_imprinting2.59798592
17MP0009840_abnormal_foam_cell2.41943541
18MP0003183_abnormal_peptide_metabolism2.38472107
19MP0003806_abnormal_nucleotide_metabolis2.37959099
20MP0002139_abnormal_hepatobiliary_system2.31602780
21MP0002735_abnormal_chemical_nociception2.22223560
22MP0001529_abnormal_vocalization2.18774328
23MP0003329_amyloid_beta_deposits2.17007966
24MP0008058_abnormal_DNA_repair2.16379901
25MP0003890_abnormal_embryonic-extraembry2.11393818
26MP0003787_abnormal_imprinting2.09375135
27MP0004885_abnormal_endolymph2.06533867
28MP0001986_abnormal_taste_sensitivity2.05122013
29MP0010678_abnormal_skin_adnexa2.04378831
30MP0006082_CNS_inflammation2.03222892
31MP0003634_abnormal_glial_cell1.98825236
32MP0003693_abnormal_embryo_hatching1.84756600
33MP0003111_abnormal_nucleus_morphology1.84406877
34MP0003136_yellow_coat_color1.83374079
35MP0010094_abnormal_chromosome_stability1.81121743
36MP0004147_increased_porphyrin_level1.80093910
37MP0006276_abnormal_autonomic_nervous1.78405385
38MP0000604_amyloidosis1.78155571
39MP0008789_abnormal_olfactory_epithelium1.74542605
40MP0009379_abnormal_foot_pigmentation1.72642777
41MP0004043_abnormal_pH_regulation1.68512288
42MP0001905_abnormal_dopamine_level1.67574278
43MP0005409_darkened_coat_color1.65920517
44MP0001293_anophthalmia1.65875195
45MP0005394_taste/olfaction_phenotype1.64619426
46MP0005499_abnormal_olfactory_system1.64619426
47MP0004134_abnormal_chest_morphology1.64529889
48MP0003303_peritoneal_inflammation1.63996181
49MP0000516_abnormal_urinary_system1.63325823
50MP0005367_renal/urinary_system_phenotyp1.63325823
51MP0004133_heterotaxia1.62622026
52MP0005075_abnormal_melanosome_morpholog1.60629037
53MP0001851_eye_inflammation1.54295980
54MP0004957_abnormal_blastocyst_morpholog1.53917324
55MP0005360_urolithiasis1.52661194
56MP0002089_abnormal_postnatal_growth/wei1.50639159
57MP0003077_abnormal_cell_cycle1.50078795
58MP0005408_hypopigmentation1.49601324
59MP0000015_abnormal_ear_pigmentation1.49383702
60MP0000685_abnormal_immune_system1.48869545
61MP0000465_gastrointestinal_hemorrhage1.48101895
62MP0003632_abnormal_nervous_system1.47411633
63MP0003656_abnormal_erythrocyte_physiolo1.45034614
64MP0005671_abnormal_response_to1.44074907
65MP0004811_abnormal_neuron_physiology1.43649880
66MP0003880_abnormal_central_pattern1.42556984
67MP0004742_abnormal_vestibular_system1.41950358
68MP0000747_muscle_weakness1.41753830
69MP0009046_muscle_twitch1.40767583
70MP0001800_abnormal_humoral_immune1.40242407
71MP0002229_neurodegeneration1.39980523
72MP0005623_abnormal_meninges_morphology1.37419574
73MP0003453_abnormal_keratinocyte_physiol1.36747070
74MP0000955_abnormal_spinal_cord1.33559160
75MP0008932_abnormal_embryonic_tissue1.32370865
76MP0003763_abnormal_thymus_physiology1.30422736
77MP0002638_abnormal_pupillary_reflex1.30192504
78MP0005000_abnormal_immune_tolerance1.27765950
79MP0002723_abnormal_immune_serum1.27718669
80MP0003300_gastrointestinal_ulcer1.26940806
81MP0004145_abnormal_muscle_electrophysio1.26806256
82MP0001440_abnormal_grooming_behavior1.26105535
83MP0002138_abnormal_hepatobiliary_system1.24270962
84MP0003631_nervous_system_phenotype1.24164086
85MP0005058_abnormal_lysosome_morphology1.23906188
86MP0009764_decreased_sensitivity_to1.23665584
87MP0002152_abnormal_brain_morphology1.22608610
88MP0003861_abnormal_nervous_system1.22338935
89MP0002733_abnormal_thermal_nociception1.21382609
90MP0000003_abnormal_adipose_tissue1.21374006
91MP0003635_abnormal_synaptic_transmissio1.21372924
92MP0001984_abnormal_olfaction1.20913334
93MP0002882_abnormal_neuron_morphology1.20851633
94MP0003633_abnormal_nervous_system1.19310643
95MP0001970_abnormal_pain_threshold1.17910108
96MP0009745_abnormal_behavioral_response1.17580094
97MP0001790_abnormal_immune_system1.17573028
98MP0005387_immune_system_phenotype1.17573028
99MP0001486_abnormal_startle_reflex1.16561432
100MP0004858_abnormal_nervous_system1.15454368
101MP0002752_abnormal_somatic_nervous1.14753882
102MP0009765_abnormal_xenobiotic_induced1.13240236
103MP0002272_abnormal_nervous_system1.12568184
104MP0002734_abnormal_mechanical_nocicepti1.12447963
105MP0001661_extended_life_span1.12377658
106MP0001919_abnormal_reproductive_system1.11516422
107MP0000383_abnormal_hair_follicle1.10984802
108MP0003186_abnormal_redox_activity1.10748124
109MP0002420_abnormal_adaptive_immunity1.06618601
110MP0005025_abnormal_response_to1.06584723
111MP0000716_abnormal_immune_system1.05568098
112MP0005174_abnormal_tail_pigmentation1.04723599
113MP0005451_abnormal_body_composition1.04072775
114MP0002933_joint_inflammation1.02505442
115MP0001324_abnormal_eye_pigmentation1.02322889
116MP0001819_abnormal_immune_cell1.01172555
117MP0002063_abnormal_learning/memory/cond1.01108429
118MP0000689_abnormal_spleen_morphology1.00450914
119MP0002398_abnormal_bone_marrow0.99554677
120MP0000631_abnormal_neuroendocrine_gland0.98962185
121MP0002090_abnormal_vision0.98793449
122MP0005464_abnormal_platelet_physiology0.98711902
123MP0001542_abnormal_bone_strength0.97406660
124MP0003698_abnormal_male_reproductive0.95778971
125MP0002419_abnormal_innate_immunity0.95470789
126MP0002697_abnormal_eye_size0.94039315
127MP0005584_abnormal_enzyme/coenzyme_acti0.93558822
128MP0002572_abnormal_emotion/affect_behav0.93022446
129MP0008569_lethality_at_weaning0.92641760
130MP0002064_seizures0.92469710
131MP0002452_abnormal_antigen_presenting0.92064068
132MP0002877_abnormal_melanocyte_morpholog0.91668156
133MP0008875_abnormal_xenobiotic_pharmacok0.91375058
134MP0000639_abnormal_adrenal_gland0.91237419
135MP0005195_abnormal_posterior_eye0.91025003
136MP0001286_abnormal_eye_development0.90792911
137MP0000647_abnormal_sebaceous_gland0.90528763
138MP0001485_abnormal_pinna_reflex0.89684548
139MP0002210_abnormal_sex_determination0.89029339
140MP0005551_abnormal_eye_electrophysiolog0.88903350
141MP0003938_abnormal_ear_development0.88821481
142MP0002557_abnormal_social/conspecific_i0.88819494
143MP0002928_abnormal_bile_duct0.88533035
144MP0001929_abnormal_gametogenesis0.88009801
145MP0002102_abnormal_ear_morphology0.87730403
146MP0004142_abnormal_muscle_tone0.87666523
147MP0002118_abnormal_lipid_homeostasis0.87612726
148MP0005085_abnormal_gallbladder_physiolo0.87418135
149MP0003755_abnormal_palate_morphology0.87362581
150MP0002396_abnormal_hematopoietic_system0.87259294
151MP0001348_abnormal_lacrimal_gland0.86934368
152MP0003191_abnormal_cellular_cholesterol0.85432551
153MP0009333_abnormal_splenocyte_physiolog0.84486203
154MP0010234_abnormal_vibrissa_follicle0.83969050
155MP0003195_calcinosis0.83128719
156MP0002067_abnormal_sensory_capabilities0.82192383
157MP0004947_skin_inflammation0.81741641
158MP0003718_maternal_effect0.81340526
159MP0003567_abnormal_fetal_cardiomyocyte0.80130179
160MP0010030_abnormal_orbit_morphology0.79124091
161MP0000462_abnormal_digestive_system0.78917895
162MP0009278_abnormal_bone_marrow0.78685689
163MP0004185_abnormal_adipocyte_glucose0.78590391
164MP0000049_abnormal_middle_ear0.78499563
165MP0002405_respiratory_system_inflammati0.78350221
166MP0004270_analgesia0.78309227
167MP0001835_abnormal_antigen_presentation0.77406022
168MP0002429_abnormal_blood_cell0.77210609
169MP0005375_adipose_tissue_phenotype0.76639668
170MP0008877_abnormal_DNA_methylation0.74870626
171MP0005248_abnormal_Harderian_gland0.74800936
172MP0003075_altered_response_to0.74434883
173MP0002066_abnormal_motor_capabilities/c0.73550336
174MP0002184_abnormal_innervation0.72649487
175MP0005310_abnormal_salivary_gland0.72601869
176MP0008874_decreased_physiological_sensi0.72384559
177MP0001243_abnormal_dermal_layer0.72251098
178MP0005448_abnormal_energy_balance0.71808345
179MP0002081_perinatal_lethality0.71715336
180MP0002233_abnormal_nose_morphology0.70041416
181MP0002069_abnormal_eating/drinking_beha0.69772136
182MP0001697_abnormal_embryo_size0.69679836
183MP0001963_abnormal_hearing_physiology0.69446912
184MP0000750_abnormal_muscle_regeneration0.66570470
185MP0001968_abnormal_touch/_nociception0.65305393
186MP0003646_muscle_fatigue0.65068855
187MP0003959_abnormal_lean_body0.63962852
188MP0009115_abnormal_fat_cell0.63807155

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)8.25650244
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)8.25650244
3Abnormality of the corticospinal tract (HP:0002492)6.23652794
4Neurofibrillary tangles (HP:0002185)5.59203087
5Absent rod-and cone-mediated responses on ERG (HP:0007688)5.02538412
6Peripheral hypomyelination (HP:0007182)4.49889992
7Cerebral inclusion bodies (HP:0100314)4.45073270
8Alacrima (HP:0000522)4.31906680
9Aplasia/Hypoplasia of the sacrum (HP:0008517)4.07007304
10Termporal pattern (HP:0011008)4.06897817
11Insidious onset (HP:0003587)4.06897817
12Spastic gait (HP:0002064)4.00227903
13Abnormality of cells of the erythroid lineage (HP:0012130)3.95998671
14Cerebral hypomyelination (HP:0006808)3.55547813
15Hyperlipoproteinemia (HP:0010980)3.46970743
16Abnormal number of erythroid precursors (HP:0012131)3.37070693
17Ependymoma (HP:0002888)3.36631688
18Supranuclear gaze palsy (HP:0000605)3.34060681
19Abnormal rod and cone electroretinograms (HP:0008323)3.33076854
20Gait imbalance (HP:0002141)3.33055799
21Abnormal auditory evoked potentials (HP:0006958)3.29666993
22Onion bulb formation (HP:0003383)3.26753727
23Myokymia (HP:0002411)3.25897806
24Volvulus (HP:0002580)3.24796935
25Decreased lacrimation (HP:0000633)3.23397439
26Stridor (HP:0010307)3.22192793
27Nephrogenic diabetes insipidus (HP:0009806)3.13939400
28Limb dystonia (HP:0002451)3.10654006
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.10076642
30Abnormality of aromatic amino acid family metabolism (HP:0004338)3.08743863
31Amblyopia (HP:0000646)3.04911711
32Anteriorly placed anus (HP:0001545)3.00199210
33Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.98187158
34Decreased activity of mitochondrial respiratory chain (HP:0008972)2.98187158
35Urinary urgency (HP:0000012)2.96143398
36Medial flaring of the eyebrow (HP:0010747)2.87877694
37Increased hepatocellular lipid droplets (HP:0006565)2.87323790
38Congenital primary aphakia (HP:0007707)2.77132550
39Abnormality of the labia minora (HP:0012880)2.75793417
40Abnormality of glycolipid metabolism (HP:0010969)2.70443366
41Abnormality of liposaccharide metabolism (HP:0010968)2.70443366
42Abnormality of glycosphingolipid metabolism (HP:0004343)2.70443366
43T lymphocytopenia (HP:0005403)2.65802759
44Hepatosplenomegaly (HP:0001433)2.65122780
45Premature skin wrinkling (HP:0100678)2.64586733
46Lissencephaly (HP:0001339)2.64293436
47Agnosia (HP:0010524)2.61942841
48Intrahepatic cholestasis (HP:0001406)2.61537750
49Limb hypertonia (HP:0002509)2.61086660
50Chronic otitis media (HP:0000389)2.60122065
51Slow saccadic eye movements (HP:0000514)2.59016677
52Reticulocytopenia (HP:0001896)2.58919435
53Peripheral demyelination (HP:0011096)2.58525836
54Nephronophthisis (HP:0000090)2.54303766
55Clumsiness (HP:0002312)2.53686036
56Sensory axonal neuropathy (HP:0003390)2.52119380
57Generalized hypotonia (HP:0001290)2.51402010
58Abnormality of T cell number (HP:0011839)2.47411951
59Thickened helices (HP:0000391)2.47069385
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.46965106
61Esophageal atresia (HP:0002032)2.46308918
62Cortical dysplasia (HP:0002539)2.45989113
63Ulnar bowing (HP:0003031)2.45903703
64Lower limb muscle weakness (HP:0007340)2.44506162
65Renal Fanconi syndrome (HP:0001994)2.41964063
66Pallor (HP:0000980)2.40916715
67CNS hypomyelination (HP:0003429)2.39761506
68Urinary bladder sphincter dysfunction (HP:0002839)2.39476526
69Increased intramyocellular lipid droplets (HP:0012240)2.39057707
70Cerebral hemorrhage (HP:0001342)2.38778389
71Rib fusion (HP:0000902)2.38084816
72Astrocytoma (HP:0009592)2.34340071
73Abnormality of the astrocytes (HP:0100707)2.34340071
74Specific learning disability (HP:0001328)2.33978541
75Leukodystrophy (HP:0002415)2.33313555
76Foot dorsiflexor weakness (HP:0009027)2.32691515
77Poor coordination (HP:0002370)2.31513834
78Absent thumb (HP:0009777)2.31229795
79Focal motor seizures (HP:0011153)2.29919919
80Molar tooth sign on MRI (HP:0002419)2.29059096
81Abnormality of midbrain morphology (HP:0002418)2.29059096
82Abnormality of the salivary glands (HP:0010286)2.29055838
83Hyperglycinemia (HP:0002154)2.28867466
84Abnormality of the lower motor neuron (HP:0002366)2.28761360
85Spastic paraparesis (HP:0002313)2.28444139
86Morphological abnormality of the inner ear (HP:0011390)2.26955059
87Morphological abnormality of the pyramidal tract (HP:0002062)2.25068789
88Abnormality of oral frenula (HP:0000190)2.24966094
89Bony spicule pigmentary retinopathy (HP:0007737)2.23703194
90Shawl scrotum (HP:0000049)2.23666411
91Loss of speech (HP:0002371)2.23410255
92Deep venous thrombosis (HP:0002625)2.22272260
93Dysmetria (HP:0001310)2.20172139
94Muscle fiber splitting (HP:0003555)2.20097215
95Pancreatic fibrosis (HP:0100732)2.18595583
96Increased neuronal autofluorescent lipopigment (HP:0002074)2.18372380
97Breast hypoplasia (HP:0003187)2.17692728
98Lipid accumulation in hepatocytes (HP:0006561)2.17593514
99Supernumerary spleens (HP:0009799)2.17587521
100Clonus (HP:0002169)2.15612129
101Pancreatic islet-cell hyperplasia (HP:0004510)2.13242942
102Spastic tetraparesis (HP:0001285)2.13111266
103Type II lissencephaly (HP:0007260)2.13007866
104Amyotrophic lateral sclerosis (HP:0007354)2.12497691
105Axonal loss (HP:0003447)2.11486612
106Macrocytic anemia (HP:0001972)2.11186445
107Abnormality of the foot musculature (HP:0001436)2.08329763
108Exotropia (HP:0000577)2.08186379
109Broad distal phalanx of finger (HP:0009836)2.07836929
110Impaired vibration sensation in the lower limbs (HP:0002166)2.07479604
111Colon cancer (HP:0003003)2.07362996
112Decreased central vision (HP:0007663)2.06967817
113Clitoromegaly (HP:0000057)2.06948829
114Paraparesis (HP:0002385)2.06754746
115Increased cerebral lipofuscin (HP:0011813)2.06291851
116Parakeratosis (HP:0001036)2.06115437
117Adrenal hypoplasia (HP:0000835)2.06080346
118Focal seizures (HP:0007359)2.01692942
119Progressive cerebellar ataxia (HP:0002073)2.00241406
120Pancreatic cysts (HP:0001737)2.00072942
121Neoplasm of striated muscle (HP:0009728)1.99675810
122Abnormal hair whorl (HP:0010721)1.99468143
123Rhabdomyosarcoma (HP:0002859)1.99299151
124Segmental peripheral demyelination/remyelination (HP:0003481)1.99219841
125Dyskinesia (HP:0100660)1.99172345
126Bowel incontinence (HP:0002607)1.98531766
127Drooling (HP:0002307)1.97483309
128Intention tremor (HP:0002080)1.96609335
129Retinal dysplasia (HP:0007973)1.96516520
130Abnormality of reticulocytes (HP:0004312)1.96455372
131Recurrent bronchitis (HP:0002837)1.94615913
132Facial hemangioma (HP:0000329)1.94528561
133Recurrent viral infections (HP:0004429)1.92044512
134Ileus (HP:0002595)1.91359261
135Spastic paraplegia (HP:0001258)1.90936559
136Abnormality of cochlea (HP:0000375)1.90560201
137Respiratory difficulties (HP:0002880)1.90064293
138Neoplasm of the oral cavity (HP:0100649)1.89696251
139Holoprosencephaly (HP:0001360)1.88262710
140Abnormal large intestine physiology (HP:0012700)1.87870797
141Depressed nasal tip (HP:0000437)1.87743615
142IgM deficiency (HP:0002850)1.87043032
143Broad-based gait (HP:0002136)1.86845566
144Birth length less than 3rd percentile (HP:0003561)1.86598483
145Abnormality of lateral ventricle (HP:0030047)1.85772904
146Abnormality of the ileum (HP:0001549)1.85390723
147Stomatitis (HP:0010280)1.85286509
148High anterior hairline (HP:0009890)1.84843192
149Excessive salivation (HP:0003781)1.84345485
150True hermaphroditism (HP:0010459)1.84088660
151Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83760814
152Hyporeflexia of lower limbs (HP:0002600)1.83255202
153Opisthotonus (HP:0002179)1.83097150
154White forelock (HP:0002211)1.83053286
155Aqueductal stenosis (HP:0002410)1.81300964
156Cone-rod dystrophy (HP:0000548)1.80972362
157Abnormality of the renal medulla (HP:0100957)1.80707969
158Vaginal atresia (HP:0000148)1.80579208
159Small intestinal stenosis (HP:0012848)1.79795186
160Duodenal stenosis (HP:0100867)1.79795186
161Meckel diverticulum (HP:0002245)1.79011206
162Depressed nasal ridge (HP:0000457)1.78399367
163Spastic tetraplegia (HP:0002510)1.78200984
164Astigmatism (HP:0000483)1.77132072
165Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.76563771
166Hypoplasia of the brainstem (HP:0002365)1.76539073
167Aplasia/Hypoplasia of the brainstem (HP:0007362)1.76539073
168Atrophy/Degeneration involving motor neurons (HP:0007373)1.76235340
169Xanthomatosis (HP:0000991)1.76192471
170Aplasia/Hypoplasia of the breasts (HP:0010311)1.75214127
171Absent/shortened dynein arms (HP:0200106)1.75110889
172Dynein arm defect of respiratory motile cilia (HP:0012255)1.75110889
173Increased nuchal translucency (HP:0010880)1.74578609
174Pulmonary embolism (HP:0002204)1.74332393
175Anencephaly (HP:0002323)1.73188856
176Ankyloglossia (HP:0010296)1.73139274
177Sloping forehead (HP:0000340)1.73056235
178Hemorrhage of the eye (HP:0011885)1.72862179
179Glioma (HP:0009733)1.72599598
180Abnormality of renal resorption (HP:0011038)1.71392717
181Exertional dyspnea (HP:0002875)1.71347408
182Neuronal loss in central nervous system (HP:0002529)1.70946024
183Dysostosis multiplex (HP:0000943)1.70893891
184Abnormal gallbladder physiology (HP:0012438)1.70737385
185Cholecystitis (HP:0001082)1.70737385
186Delayed CNS myelination (HP:0002188)1.69909667
187Aplasia/Hypoplasia of the nipples (HP:0006709)1.69368989
188Buphthalmos (HP:0000557)1.69299967
189Stenosis of the external auditory canal (HP:0000402)1.68126930
190Patchy hypopigmentation of hair (HP:0011365)1.68117602
191Turricephaly (HP:0000262)1.67826323
192Abnormality of saccadic eye movements (HP:0000570)1.66487333
193Steatorrhea (HP:0002570)1.64013389
194Increased mean platelet volume (HP:0011877)1.63062017
195Conjunctival telangiectasia (HP:0000524)1.61980575
196Paraplegia (HP:0010550)1.57601168
197Abnormality of aspartate family amino acid metabolism (HP:0010899)1.57208017
198Bell-shaped thorax (HP:0001591)1.56766927
199Recurrent skin infections (HP:0001581)1.56621382

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.83542843
2STK394.58670274
3EPHB13.43610103
4PKN13.36599049
5MAP3K133.36511564
6ERN12.82222576
7DYRK1B2.74279734
8NEK12.70007892
9CDC72.69548830
10PLK42.62448409
11FGFR22.62413254
12OXSR12.57442099
13MARK12.55705645
14MAP4K12.36066159
15CLK12.30360083
16IRAK22.27947706
17MINK12.24109393
18DYRK32.19260785
19CASK2.08196092
20EPHB22.07664861
21STK101.96596415
22PIM21.89674820
23MAP3K101.86095544
24CCNB11.85494017
25FGR1.78779391
26BUB11.76004236
27MAP3K121.72522789
28MAP3K111.71281102
29MAPKAPK51.70301301
30ICK1.69353775
31CSF1R1.69231870
32MAP3K91.65700824
33UHMK11.65659469
34MET1.62779700
35TTK1.58581194
36WNK11.56765565
37NME21.50188195
38WEE11.50040547
39AURKA1.47350393
40ACVR1B1.44408582
41MAP2K71.42832869
42EPHA41.35562378
43FES1.32679573
44ARAF1.31134447
45TAF11.28340662
46PDK21.27745721
47BMX1.26618185
48CSK1.24812891
49GRK61.23583298
50BMPR1B1.23374433
51ROCK21.23183474
52PRKCQ1.22610714
53TYRO31.19228688
54DYRK1A1.16166959
55BCR1.14665989
56MST41.14639610
57MKNK21.13703956
58PNCK1.13242394
59ITK1.12018198
60CAMK2B1.09474831
61PLK11.09212871
62NTRK31.08613542
63NTRK21.07639353
64CSNK1A1L1.05756731
65CSNK1G31.05585498
66LRRK21.05187329
67CAMKK21.03794535
68PRKD31.02424766
69PDK11.01606960
70PHKG11.01040105
71PHKG21.01040105
72WNK41.00562646
73LCK0.99184649
74SIK30.98602947
75ALK0.98345502
76BCKDK0.96774682
77PDPK10.96522558
78MAP3K40.96244826
79ATR0.95722697
80IRAK30.95565695
81CSNK1G10.94411558
82CDK190.93694140
83ERBB30.93311487
84PRKCG0.89597434
85MAPK130.89503545
86MAP2K40.88462612
87KIT0.86300756
88CHEK20.85942290
89MARK30.85909361
90PRKCH0.82180872
91NTRK10.81505723
92MAPK150.81225123
93LIMK10.79689683
94TYK20.78933897
95PRPF4B0.77230189
96ZAK0.76775621
97MOS0.76562696
98TRPM70.76107565
99SRPK10.74927503
100TESK10.74132439
101MAP3K80.73958968
102EEF2K0.73365962
103STK30.73221495
104NME10.73177394
105BRAF0.73036028
106PDGFRB0.71455830
107PRKCZ0.70985686
108AURKB0.69922958
109IRAK10.69653354
110CAMK2D0.68500045
111HCK0.67106768
112PBK0.66176483
113DMPK0.65996522
114KSR20.65821790
115CAMK1G0.64809103
116RAF10.62879764
117CSNK2A20.60488619
118DDR20.60474898
119BRD40.59408082
120PRKD10.59291135
121CSNK1D0.56815939
122CDK70.55602870
123PTK20.55516646
124CDK30.55265123
125YES10.55093218
126SIK20.54997484
127FYN0.54843899
128HIPK20.54582115
129CDK140.54142035
130PTK2B0.54059289
131PAK30.53483356
132CSNK1G20.52546009
133CDK80.52377653
134CAMK10.52327596
135CHEK10.52304299
136MARK20.52152905
137PRKCI0.52058336
138MAP3K50.51179513
139TGFBR10.51110846
140CDK10.51082325
141CDK180.48726432
142CDK50.48347400
143CDK11A0.47407696
144CAMK2G0.45896326
145CDK150.45342884
146BTK0.45059401
147SYK0.44730807
148PASK0.44168234
149DAPK30.44040172
150GSK3A0.43544358
151PAK20.42650996
152CDK20.42119817
153TIE10.42086981
154IRAK40.41858721
155CSNK1E0.40643669
156PAK10.40416652
157TNIK0.40053495
158INSR0.39734896
159PRKDC0.39448020
160SGK2230.39249134
161SGK4940.39249134
162BRSK10.39219974
163ERBB40.39064675
164NEK20.38906677
165PTK60.38824064
166EGFR0.38798374
167BLK0.38572678
168VRK20.38492914
169ATM0.38025066
170MATK0.37240694
171FGFR40.36733144
172DYRK20.36657654
173CAMK1D0.36161677
174STK110.34901561
175TAOK20.34627205
176PLK30.33117927

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.35240414
2Ribosome_Homo sapiens_hsa030104.90793487
3Fatty acid elongation_Homo sapiens_hsa000624.80778643
4Steroid biosynthesis_Homo sapiens_hsa001003.90859097
5Oxidative phosphorylation_Homo sapiens_hsa001903.32642615
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.28716251
7DNA replication_Homo sapiens_hsa030303.11181139
8Parkinsons disease_Homo sapiens_hsa050123.00926367
9Vitamin B6 metabolism_Homo sapiens_hsa007502.96570550
10Base excision repair_Homo sapiens_hsa034102.76516458
11RNA polymerase_Homo sapiens_hsa030202.72137202
12Histidine metabolism_Homo sapiens_hsa003402.68661064
13Cardiac muscle contraction_Homo sapiens_hsa042602.49941672
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.48857860
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.46937693
16Ether lipid metabolism_Homo sapiens_hsa005652.38863103
17Huntingtons disease_Homo sapiens_hsa050162.36890843
18Mismatch repair_Homo sapiens_hsa034302.25148594
19Fanconi anemia pathway_Homo sapiens_hsa034602.23191773
20Spliceosome_Homo sapiens_hsa030402.17846332
21Nitrogen metabolism_Homo sapiens_hsa009102.12171744
22Basal transcription factors_Homo sapiens_hsa030222.02835891
23B cell receptor signaling pathway_Homo sapiens_hsa046622.00748549
24RNA degradation_Homo sapiens_hsa030181.94882205
25Folate biosynthesis_Homo sapiens_hsa007901.94484167
26Alzheimers disease_Homo sapiens_hsa050101.92188749
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.87795917
28Primary immunodeficiency_Homo sapiens_hsa053401.86784737
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.85613608
30Homologous recombination_Homo sapiens_hsa034401.85602464
31Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.85313938
32Nicotine addiction_Homo sapiens_hsa050331.72931397
33Pyrimidine metabolism_Homo sapiens_hsa002401.67937033
34RNA transport_Homo sapiens_hsa030131.67712639
35Fatty acid metabolism_Homo sapiens_hsa012121.65962750
36Arginine and proline metabolism_Homo sapiens_hsa003301.61725626
37Cell cycle_Homo sapiens_hsa041101.60190278
38Renal cell carcinoma_Homo sapiens_hsa052111.53096729
39Fatty acid biosynthesis_Homo sapiens_hsa000611.51487484
40Nucleotide excision repair_Homo sapiens_hsa034201.43556351
41Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.43233075
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.42050357
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.40756547
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.39415015
45Linoleic acid metabolism_Homo sapiens_hsa005911.31037072
46Proteasome_Homo sapiens_hsa030501.29422245
47One carbon pool by folate_Homo sapiens_hsa006701.26530045
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25142618
49T cell receptor signaling pathway_Homo sapiens_hsa046601.24458753
50Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.24358973
51Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21869424
52mRNA surveillance pathway_Homo sapiens_hsa030151.19634140
53Axon guidance_Homo sapiens_hsa043601.19457951
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.17762431
55Notch signaling pathway_Homo sapiens_hsa043301.16797457
56Propanoate metabolism_Homo sapiens_hsa006401.16457785
57Arginine biosynthesis_Homo sapiens_hsa002201.13614789
58Staphylococcus aureus infection_Homo sapiens_hsa051501.10634091
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08129384
60Complement and coagulation cascades_Homo sapiens_hsa046101.05909805
61Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05623898
62Phagosome_Homo sapiens_hsa041451.05371095
63Collecting duct acid secretion_Homo sapiens_hsa049661.02094263
64Butanoate metabolism_Homo sapiens_hsa006501.00417391
65Synaptic vesicle cycle_Homo sapiens_hsa047210.97729295
66Tryptophan metabolism_Homo sapiens_hsa003800.97147729
67Sphingolipid signaling pathway_Homo sapiens_hsa040710.96301478
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95277437
69Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.94750400
70ABC transporters_Homo sapiens_hsa020100.94659672
71Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94398469
72Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.92928824
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92065371
74Fatty acid degradation_Homo sapiens_hsa000710.91653504
75Glutathione metabolism_Homo sapiens_hsa004800.90326427
76Salmonella infection_Homo sapiens_hsa051320.88880658
77Endocytosis_Homo sapiens_hsa041440.87429299
78Leukocyte transendothelial migration_Homo sapiens_hsa046700.85988701
79p53 signaling pathway_Homo sapiens_hsa041150.85480874
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85346947
81Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.84179949
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84055107
83Peroxisome_Homo sapiens_hsa041460.81830547
84Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81817690
85PPAR signaling pathway_Homo sapiens_hsa033200.81624701
86Lysosome_Homo sapiens_hsa041420.80672593
87Purine metabolism_Homo sapiens_hsa002300.80648623
88Pancreatic cancer_Homo sapiens_hsa052120.79795468
89Protein export_Homo sapiens_hsa030600.78973897
90Dorso-ventral axis formation_Homo sapiens_hsa043200.78961468
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78716337
92Morphine addiction_Homo sapiens_hsa050320.78078495
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77935463
94Pyruvate metabolism_Homo sapiens_hsa006200.77528573
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.77350766
96GABAergic synapse_Homo sapiens_hsa047270.76966944
97Autoimmune thyroid disease_Homo sapiens_hsa053200.76139701
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.75503799
99Oocyte meiosis_Homo sapiens_hsa041140.74752865
100Dopaminergic synapse_Homo sapiens_hsa047280.74030699
101Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70501477
102Chemical carcinogenesis_Homo sapiens_hsa052040.69958367
103Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.69613596
104Prostate cancer_Homo sapiens_hsa052150.69373692
105Chemokine signaling pathway_Homo sapiens_hsa040620.68943828
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66446624
107Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64365243
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62710690
109Hematopoietic cell lineage_Homo sapiens_hsa046400.62075380
110Carbon metabolism_Homo sapiens_hsa012000.60802054
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60230037
112beta-Alanine metabolism_Homo sapiens_hsa004100.60154006
113Bile secretion_Homo sapiens_hsa049760.58164151
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.58027855
115Choline metabolism in cancer_Homo sapiens_hsa052310.57707025
116Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57273894
117Sulfur relay system_Homo sapiens_hsa041220.55918285
118Long-term depression_Homo sapiens_hsa047300.54441548
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.54256833
120Epstein-Barr virus infection_Homo sapiens_hsa051690.53850404
121Glycerophospholipid metabolism_Homo sapiens_hsa005640.53620776
122Shigellosis_Homo sapiens_hsa051310.53577998
123Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53423764
124Selenocompound metabolism_Homo sapiens_hsa004500.52555204
125Metabolic pathways_Homo sapiens_hsa011000.52336368
126Retinol metabolism_Homo sapiens_hsa008300.52331807
127Olfactory transduction_Homo sapiens_hsa047400.51340096
128Biosynthesis of amino acids_Homo sapiens_hsa012300.51125664
129Glycerolipid metabolism_Homo sapiens_hsa005610.50976241
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50923202
131Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49802995
132Acute myeloid leukemia_Homo sapiens_hsa052210.49365430
133Non-small cell lung cancer_Homo sapiens_hsa052230.47622219
134Cholinergic synapse_Homo sapiens_hsa047250.47195126
135Phototransduction_Homo sapiens_hsa047440.47005829
136Colorectal cancer_Homo sapiens_hsa052100.46723128
137Prion diseases_Homo sapiens_hsa050200.45859679
138Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45343985
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43925114
140Basal cell carcinoma_Homo sapiens_hsa052170.41748377
141Ras signaling pathway_Homo sapiens_hsa040140.41515440
142Non-homologous end-joining_Homo sapiens_hsa034500.39524805
143Hippo signaling pathway_Homo sapiens_hsa043900.39497543
144Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.39227300
145ErbB signaling pathway_Homo sapiens_hsa040120.37440010
146Sphingolipid metabolism_Homo sapiens_hsa006000.37201008
147Malaria_Homo sapiens_hsa051440.36990821
148Sulfur metabolism_Homo sapiens_hsa009200.35976768
149Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.35963124
150Pentose phosphate pathway_Homo sapiens_hsa000300.34714978
151Melanoma_Homo sapiens_hsa052180.32909807
152Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.31827187
153Chronic myeloid leukemia_Homo sapiens_hsa052200.31553943
154Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.31439397
155Osteoclast differentiation_Homo sapiens_hsa043800.29916802
156NF-kappa B signaling pathway_Homo sapiens_hsa040640.29216146
157Cysteine and methionine metabolism_Homo sapiens_hsa002700.28105791
158VEGF signaling pathway_Homo sapiens_hsa043700.27652863
159NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27231916
160MAPK signaling pathway_Homo sapiens_hsa040100.27123088
161Tight junction_Homo sapiens_hsa045300.24763390
162Taste transduction_Homo sapiens_hsa047420.24685881
163Platelet activation_Homo sapiens_hsa046110.24631822
164Tyrosine metabolism_Homo sapiens_hsa003500.22874078
165Glycosaminoglycan degradation_Homo sapiens_hsa005310.22782744
166Lysine degradation_Homo sapiens_hsa003100.22643939
167Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21748278
168Endometrial cancer_Homo sapiens_hsa052130.17453002
169Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.16123478
170Rap1 signaling pathway_Homo sapiens_hsa040150.14559877
171Type II diabetes mellitus_Homo sapiens_hsa049300.14487147
172Hedgehog signaling pathway_Homo sapiens_hsa043400.13370333
173Glutamatergic synapse_Homo sapiens_hsa047240.13353676

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