TMEM68

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.16369588
2presynaptic membrane organization (GO:0097090)5.78289944
3neuron cell-cell adhesion (GO:0007158)5.13338324
4behavioral response to nicotine (GO:0035095)4.61121121
5negative regulation of synaptic transmission, GABAergic (GO:0032229)4.55376609
6regulation of synaptic vesicle exocytosis (GO:2000300)4.41935333
7synaptic vesicle exocytosis (GO:0016079)4.41748350
8neurotransmitter-gated ion channel clustering (GO:0072578)4.37542352
9regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31596108
10gamma-aminobutyric acid signaling pathway (GO:0007214)4.26493953
11transferrin transport (GO:0033572)4.20649476
12energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.14482553
13ATP hydrolysis coupled proton transport (GO:0015991)4.14482553
14postsynaptic membrane organization (GO:0001941)4.09818620
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.06271838
16epithelial cilium movement (GO:0003351)4.05421246
17regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.00857311
18response to histamine (GO:0034776)3.90071048
19neuron-neuron synaptic transmission (GO:0007270)3.89000946
20trivalent inorganic cation transport (GO:0072512)3.86903414
21ferric iron transport (GO:0015682)3.86903414
22phagosome maturation (GO:0090382)3.86094663
23neuronal action potential propagation (GO:0019227)3.81456794
24ionotropic glutamate receptor signaling pathway (GO:0035235)3.81407826
25water-soluble vitamin biosynthetic process (GO:0042364)3.79264780
26L-fucose catabolic process (GO:0042355)3.76770518
27fucose catabolic process (GO:0019317)3.76770518
28L-fucose metabolic process (GO:0042354)3.76770518
29vocalization behavior (GO:0071625)3.75361484
30glutamate receptor signaling pathway (GO:0007215)3.74737817
31synaptic transmission, glutamatergic (GO:0035249)3.70070229
32protein localization to synapse (GO:0035418)3.69020655
33regulation of synaptic vesicle transport (GO:1902803)3.62964341
34cerebellar granule cell differentiation (GO:0021707)3.61377050
35indole-containing compound catabolic process (GO:0042436)3.59021474
36indolalkylamine catabolic process (GO:0046218)3.59021474
37tryptophan catabolic process (GO:0006569)3.59021474
38DNA deamination (GO:0045006)3.56810436
39positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.54586950
40cilium movement (GO:0003341)3.53092316
41neural tube formation (GO:0001841)3.52486214
42axoneme assembly (GO:0035082)3.52412718
43startle response (GO:0001964)3.49397957
44mitochondrial respiratory chain complex I assembly (GO:0032981)3.46825076
45NADH dehydrogenase complex assembly (GO:0010257)3.46825076
46mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.46825076
47regulation of glutamate receptor signaling pathway (GO:1900449)3.45789438
48long-term synaptic potentiation (GO:0060291)3.44270203
49regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.43686079
50positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.43686079
51regulation of glutamate secretion (GO:0014048)3.42990156
52kynurenine metabolic process (GO:0070189)3.42948127
53regulation of short-term neuronal synaptic plasticity (GO:0048172)3.42223839
54response to pheromone (GO:0019236)3.36704180
55indolalkylamine metabolic process (GO:0006586)3.36433580
56cellular ketone body metabolic process (GO:0046950)3.34563090
57negative regulation of neurotransmitter transport (GO:0051589)3.34326980
58negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.33419234
59glutamate secretion (GO:0014047)3.29980860
60membrane assembly (GO:0071709)3.27655164
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.27619788
62cilium or flagellum-dependent cell motility (GO:0001539)3.27369749
63synaptic vesicle docking involved in exocytosis (GO:0016081)3.24069528
64negative regulation of interleukin-17 production (GO:0032700)3.23649697
65long-chain fatty acid biosynthetic process (GO:0042759)3.22919666
66regulation of cilium movement (GO:0003352)3.20743605
67sulfation (GO:0051923)3.19991177
68G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.18779795
69positive regulation of synapse assembly (GO:0051965)3.18389833
70mitochondrial respiratory chain complex assembly (GO:0033108)3.18223219
71regulation of mesoderm development (GO:2000380)3.17702594
72tryptophan metabolic process (GO:0006568)3.16945251
73platelet dense granule organization (GO:0060155)3.16418877
74detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.15445031
75regulation of synaptic transmission, glutamatergic (GO:0051966)3.15164557
76somite development (GO:0061053)3.15087981
77respiratory chain complex IV assembly (GO:0008535)3.14843251
78mechanosensory behavior (GO:0007638)3.14174058
79axonemal dynein complex assembly (GO:0070286)3.13531552
80protein neddylation (GO:0045116)3.11537659
81negative regulation of neurotransmitter secretion (GO:0046929)3.11484939
82neurotransmitter uptake (GO:0001504)3.11370698
83cilium morphogenesis (GO:0060271)3.10480549
84protein polyglutamylation (GO:0018095)3.09855182
85DNA double-strand break processing (GO:0000729)3.09834518
86negative regulation of transcription regulatory region DNA binding (GO:2000678)3.09084249
87pH reduction (GO:0045851)3.07178107
88behavioral response to cocaine (GO:0048148)3.04246859
89cornea development in camera-type eye (GO:0061303)3.02499588
90preassembly of GPI anchor in ER membrane (GO:0016254)3.01404626
91regulation of excitatory postsynaptic membrane potential (GO:0060079)3.00705899
92ketone body metabolic process (GO:1902224)3.00124371
93regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99103307
94nonmotile primary cilium assembly (GO:0035058)2.98694105
95kidney morphogenesis (GO:0060993)2.97370657
96nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94908925
97negative regulation of dendrite morphogenesis (GO:0050774)2.94731149
98regulation of neurotransmitter secretion (GO:0046928)2.91140900
99intracellular pH reduction (GO:0051452)2.90634226
100positive regulation of membrane potential (GO:0045838)2.89632245
101chaperone-mediated protein transport (GO:0072321)2.88895994
102replication fork processing (GO:0031297)2.88755324
103positive regulation of neurotransmitter secretion (GO:0001956)2.88025493
104intraciliary transport (GO:0042073)2.87441219
105regulation of postsynaptic membrane potential (GO:0060078)2.86973825
106cilium organization (GO:0044782)2.86768462
107mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.86042970
108opioid receptor signaling pathway (GO:0038003)2.85636096
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.84826372
110RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84170067
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84170067
112protein-cofactor linkage (GO:0018065)2.84095294
113negative regulation of telomere maintenance (GO:0032205)2.82551374
114cytochrome complex assembly (GO:0017004)2.79844269
115GPI anchor metabolic process (GO:0006505)2.78154388
116recombinational repair (GO:0000725)2.77944389
117detection of light stimulus involved in sensory perception (GO:0050962)2.77040619
118detection of light stimulus involved in visual perception (GO:0050908)2.77040619
119negative regulation of amino acid transport (GO:0051956)2.76667250
120neuron recognition (GO:0008038)2.76268650
121piRNA metabolic process (GO:0034587)2.75870575
122cilium assembly (GO:0042384)2.75349216
123limb bud formation (GO:0060174)2.75324329
124double-strand break repair via homologous recombination (GO:0000724)2.74919695
125transmission of nerve impulse (GO:0019226)2.74737499
126neurotransmitter secretion (GO:0007269)2.73068108
127regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72677585
128negative regulation of synaptic transmission (GO:0050805)2.71169144
129retinal cone cell development (GO:0046549)2.69943412
130ATP synthesis coupled proton transport (GO:0015986)2.69360036
131energy coupled proton transport, down electrochemical gradient (GO:0015985)2.69360036
132membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.69294867
133photoreceptor cell development (GO:0042461)2.68442979
134female mating behavior (GO:0060180)2.67972436
135rRNA catabolic process (GO:0016075)2.67888683
136mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.67863878
137positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.66834622
138L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.65143593
139regulation of neurotransmitter transport (GO:0051588)2.65089924
140regulation of isotype switching to IgG isotypes (GO:0048302)2.63218734
141hindbrain development (GO:0030902)2.62437582
142regulation of amino acid transport (GO:0051955)2.62144331
143negative regulation of exocytosis (GO:0045920)2.61936795
144positive regulation of neurotransmitter transport (GO:0051590)2.61854606
145positive regulation of synaptic transmission (GO:0050806)2.61816827
146positive regulation of protein homodimerization activity (GO:0090073)2.61681614
147dendrite development (GO:0016358)2.60669287
148regulation of synaptic transmission, GABAergic (GO:0032228)2.59452634
149positive regulation of oligodendrocyte differentiation (GO:0048714)2.58128601
150synaptic vesicle endocytosis (GO:0048488)2.58064550
151embryonic epithelial tube formation (GO:0001838)2.57812165
152mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.57594660
153ubiquinone biosynthetic process (GO:0006744)2.57043458
154cullin deneddylation (GO:0010388)2.56350179
155regulation of female receptivity (GO:0045924)2.56148985
156ubiquinone metabolic process (GO:0006743)2.55800737
157regulation of voltage-gated calcium channel activity (GO:1901385)2.55651575
158regulation of synaptic plasticity (GO:0048167)2.55352178
159photoreceptor cell maintenance (GO:0045494)2.54253444
160exploration behavior (GO:0035640)2.53651670
161regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.53466724
162synaptic transmission, dopaminergic (GO:0001963)2.53062085
163serotonin receptor signaling pathway (GO:0007210)2.52082199
164regulation of nuclear cell cycle DNA replication (GO:0033262)2.51956266
165mannosylation (GO:0097502)2.51626535
166indole-containing compound metabolic process (GO:0042430)2.51414194
167regulation of synapse assembly (GO:0051963)2.50936267
168amine catabolic process (GO:0009310)2.48924650
169cellular biogenic amine catabolic process (GO:0042402)2.48924650
170dopamine transport (GO:0015872)2.48670937
171learning (GO:0007612)2.48463209
172regulation of interleukin-17 production (GO:0032660)2.48364913
173spinal cord motor neuron differentiation (GO:0021522)2.47959222
174signal peptide processing (GO:0006465)2.47653334
175positive regulation of mitochondrial fission (GO:0090141)2.47560318
176establishment of protein localization to mitochondrial membrane (GO:0090151)2.47087742
177sleep (GO:0030431)2.47054187
178prostate gland growth (GO:0060736)2.43957660
179eye photoreceptor cell development (GO:0042462)2.42194967
180regulation of rhodopsin mediated signaling pathway (GO:0022400)2.42103276
181synapsis (GO:0007129)2.41788244
182gamma-aminobutyric acid transport (GO:0015812)2.41748692
183oxidative demethylation (GO:0070989)2.41556846
184iron ion transport (GO:0006826)2.41546754
185protein localization to cilium (GO:0061512)2.40503676
186locomotory exploration behavior (GO:0035641)2.40411439
187protein K11-linked deubiquitination (GO:0035871)2.40273810
188response to cocaine (GO:0042220)2.40054474
189protein complex biogenesis (GO:0070271)2.39803382
190reflex (GO:0060004)2.39743911
191S-adenosylmethionine metabolic process (GO:0046500)2.38824231
192rhodopsin mediated signaling pathway (GO:0016056)2.38792442
193epithelial tube formation (GO:0072175)2.38752170
194L-methionine salvage (GO:0071267)2.36744988
195L-methionine biosynthetic process (GO:0071265)2.36744988
196amino acid salvage (GO:0043102)2.36744988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.91122107
2ZNF274_21170338_ChIP-Seq_K562_Hela3.68627659
3TAF15_26573619_Chip-Seq_HEK293_Human3.49200608
4EZH2_22144423_ChIP-Seq_EOC_Human3.13367087
5* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.91165480
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.78794995
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.75431137
8POU3F2_20337985_ChIP-ChIP_501MEL_Human2.73358381
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.49246962
10CTBP2_25329375_ChIP-Seq_LNCAP_Human2.45762685
11FUS_26573619_Chip-Seq_HEK293_Human2.39082355
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33217654
13P300_19829295_ChIP-Seq_ESCs_Human2.32094767
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27201793
15* GABP_17652178_ChIP-ChIP_JURKAT_Human2.22739021
16MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.20993733
17CTBP1_25329375_ChIP-Seq_LNCAP_Human2.19015707
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17910289
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.12994171
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.06768341
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.05905736
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.05223579
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04669803
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.00566813
25AR_21572438_ChIP-Seq_LNCaP_Human1.98712405
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.95575778
27FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.93582404
28SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.92220958
29SMAD4_21799915_ChIP-Seq_A2780_Human1.91231920
30VDR_22108803_ChIP-Seq_LS180_Human1.90745670
31* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.90715042
32ER_23166858_ChIP-Seq_MCF-7_Human1.88781277
33EZH2_27304074_Chip-Seq_ESCs_Mouse1.87123963
34REST_21632747_ChIP-Seq_MESCs_Mouse1.83824781
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79321750
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79127695
37SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.76034172
38ELK1_19687146_ChIP-ChIP_HELA_Human1.73204949
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.72953308
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.72262376
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.71871111
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71747775
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.69919249
44IGF1R_20145208_ChIP-Seq_DFB_Human1.69354358
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68144282
46TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66699549
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.65838388
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.63610004
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.63497429
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.63287279
51EWS_26573619_Chip-Seq_HEK293_Human1.62850633
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.60229637
53RNF2_27304074_Chip-Seq_NSC_Mouse1.60196512
54* MYC_18940864_ChIP-ChIP_HL60_Human1.57792812
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.55071127
56CBP_20019798_ChIP-Seq_JUKART_Human1.52360348
57IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52360348
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51895711
59AR_25329375_ChIP-Seq_VCAP_Human1.51311550
60TP53_22573176_ChIP-Seq_HFKS_Human1.50299889
61RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49811389
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49811389
63MTF2_20144788_ChIP-Seq_MESCs_Mouse1.49589526
64JARID2_20075857_ChIP-Seq_MESCs_Mouse1.47507313
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.47042265
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46720823
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.46639549
68* REST_18959480_ChIP-ChIP_MESCs_Mouse1.44962997
69* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.44684598
70BCAT_22108803_ChIP-Seq_LS180_Human1.42851166
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.39846331
72EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.39165138
73FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38946281
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.38540533
75NANOG_19829295_ChIP-Seq_ESCs_Human1.36882081
76SOX2_19829295_ChIP-Seq_ESCs_Human1.36882081
77P53_22387025_ChIP-Seq_ESCs_Mouse1.36583140
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.36486229
79* VDR_23849224_ChIP-Seq_CD4+_Human1.36198997
80TP53_18474530_ChIP-ChIP_U2OS_Human1.33958701
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.33848300
82FOXA1_27270436_Chip-Seq_PROSTATE_Human1.33848300
83E2F1_18555785_Chip-Seq_ESCs_Mouse1.33732994
84CMYC_18555785_Chip-Seq_ESCs_Mouse1.32577264
85NFE2_27457419_Chip-Seq_LIVER_Mouse1.32571094
86SUZ12_18555785_Chip-Seq_ESCs_Mouse1.31980907
87VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.31914671
88PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29716652
89NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29389600
90TCF4_22108803_ChIP-Seq_LS180_Human1.28328728
91AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27812172
92JUN_21703547_ChIP-Seq_K562_Human1.27175752
93SUZ12_27294783_Chip-Seq_ESCs_Mouse1.27118324
94IRF8_21731497_ChIP-ChIP_J774_Mouse1.26943162
95RNF2_27304074_Chip-Seq_ESCs_Mouse1.26630844
96TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.25342029
97TCF4_23295773_ChIP-Seq_U87_Human1.24618582
98STAT3_23295773_ChIP-Seq_U87_Human1.23374320
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23201417
100FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23129053
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.22607524
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.22228928
103CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22166421
104STAT3_18555785_Chip-Seq_ESCs_Mouse1.21827068
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.21748317
106RARB_27405468_Chip-Seq_BRAIN_Mouse1.21351503
107RUNX2_22187159_ChIP-Seq_PCA_Human1.20393827
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.19871696
109EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.18584065
110MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.18485717
111EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18292200
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.17855325
113AR_20517297_ChIP-Seq_VCAP_Human1.15186363
114P300_18555785_Chip-Seq_ESCs_Mouse1.15183121
115TAL1_26923725_Chip-Seq_HPCs_Mouse1.15155889
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.14785167
117SOX2_21211035_ChIP-Seq_LN229_Gbm1.13332107
118GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12943679
119NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11664170
120NCOR_22424771_ChIP-Seq_293T_Human1.11534452
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11104021
122NMYC_18555785_Chip-Seq_ESCs_Mouse1.10295016
123IRF1_19129219_ChIP-ChIP_H3396_Human1.09883558
124SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09159722
125KDM2B_26808549_Chip-Seq_REH_Human1.08723964
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08547669
127POU5F1_16153702_ChIP-ChIP_HESCs_Human1.07404770
128AUTS2_25519132_ChIP-Seq_293T-REX_Human1.07376689
129P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06432390
130RUNX1_27457419_Chip-Seq_LIVER_Mouse1.06032401
131CDX2_22108803_ChIP-Seq_LS180_Human1.05959804
132ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05587300
133SMAD4_21741376_ChIP-Seq_EPCs_Human1.05585400
134CRX_20693478_ChIP-Seq_RETINA_Mouse1.05503267
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.05027700
136PADI4_21655091_ChIP-ChIP_MCF-7_Human1.04918984
137GATA3_21878914_ChIP-Seq_MCF-7_Human1.04692849
138EZH2_27294783_Chip-Seq_NPCs_Mouse1.04248328
139POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03810421
140TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03810421
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03768733
142NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03747451
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03747451
144SOX9_26525672_Chip-Seq_HEART_Mouse1.03196453
145ETS1_20019798_ChIP-Seq_JURKAT_Human1.02255456
146HOXB7_26014856_ChIP-Seq_BT474_Human1.01972037
147FLI1_21867929_ChIP-Seq_TH2_Mouse1.00827609
148EGR1_23403033_ChIP-Seq_LIVER_Mouse1.00622720
149SRF_21415370_ChIP-Seq_HL-1_Mouse0.97623122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.42127250
2MP0004859_abnormal_synaptic_plasticity3.89683790
3MP0003635_abnormal_synaptic_transmissio3.33064499
4MP0009046_muscle_twitch3.25681298
5MP0009745_abnormal_behavioral_response3.22649905
6MP0002736_abnormal_nociception_after3.18289885
7MP0002064_seizures3.17681591
8MP0001968_abnormal_touch/_nociception3.08700218
9MP0004270_analgesia2.98377166
10MP0002063_abnormal_learning/memory/cond2.94353710
11MP0002572_abnormal_emotion/affect_behav2.72467493
12MP0003195_calcinosis2.72284601
13MP0001188_hyperpigmentation2.71884791
14MP0002102_abnormal_ear_morphology2.65667977
15MP0002272_abnormal_nervous_system2.58505436
16MP0001529_abnormal_vocalization2.48640710
17MP0002734_abnormal_mechanical_nocicepti2.36618143
18MP0006072_abnormal_retinal_apoptosis2.31860779
19MP0002837_dystrophic_cardiac_calcinosis2.21700171
20MP0001486_abnormal_startle_reflex2.20198102
21MP0001440_abnormal_grooming_behavior2.17098488
22MP0002735_abnormal_chemical_nociception2.13227357
23MP0009780_abnormal_chondrocyte_physiolo2.11393549
24MP0002938_white_spotting2.11318932
25MP0002067_abnormal_sensory_capabilities2.10116107
26MP0001501_abnormal_sleep_pattern2.06869439
27MP0001905_abnormal_dopamine_level2.01388463
28MP0005646_abnormal_pituitary_gland1.95931750
29MP0005171_absent_coat_pigmentation1.90387765
30MP0002638_abnormal_pupillary_reflex1.88493550
31MP0004142_abnormal_muscle_tone1.82674284
32MP0005671_abnormal_response_to1.81433362
33MP0002138_abnormal_hepatobiliary_system1.80572219
34MP0002234_abnormal_pharynx_morphology1.80294000
35MP0008872_abnormal_physiological_respon1.74693501
36MP0001970_abnormal_pain_threshold1.73190894
37MP0003646_muscle_fatigue1.72150715
38MP0005253_abnormal_eye_physiology1.71609109
39MP0003183_abnormal_peptide_metabolism1.71336566
40MP0002876_abnormal_thyroid_physiology1.70308066
41MP0008875_abnormal_xenobiotic_pharmacok1.68572920
42MP0006276_abnormal_autonomic_nervous1.68395410
43MP0000427_abnormal_hair_cycle1.67311335
44MP0008789_abnormal_olfactory_epithelium1.64866617
45MP0008569_lethality_at_weaning1.60342033
46MP0005386_behavior/neurological_phenoty1.58970133
47MP0004924_abnormal_behavior1.58970133
48MP0000569_abnormal_digit_pigmentation1.58037270
49MP0002653_abnormal_ependyma_morphology1.53937525
50MP0004147_increased_porphyrin_level1.53549991
51MP0000778_abnormal_nervous_system1.53349221
52MP0003011_delayed_dark_adaptation1.52074103
53MP0004133_heterotaxia1.51406463
54MP0003879_abnormal_hair_cell1.51365863
55MP0002733_abnormal_thermal_nociception1.50858777
56MP0000383_abnormal_hair_follicle1.48879059
57MP0003787_abnormal_imprinting1.46699718
58MP0004043_abnormal_pH_regulation1.40534154
59MP0010386_abnormal_urinary_bladder1.35091210
60MP0008058_abnormal_DNA_repair1.35033662
61MP0003718_maternal_effect1.34550182
62MP0004742_abnormal_vestibular_system1.34214579
63MP0001984_abnormal_olfaction1.33283686
64MP0000920_abnormal_myelination1.33110205
65MP0002557_abnormal_social/conspecific_i1.30874103
66MP0004885_abnormal_endolymph1.27666009
67MP0002184_abnormal_innervation1.27273405
68MP0005174_abnormal_tail_pigmentation1.27006913
69MP0002160_abnormal_reproductive_system1.26245076
70MP0004145_abnormal_muscle_electrophysio1.25310629
71MP0003283_abnormal_digestive_organ1.24189542
72MP0005389_reproductive_system_phenotype1.22217396
73MP0003119_abnormal_digestive_system1.21331398
74MP0005423_abnormal_somatic_nervous1.19536215
75MP0003890_abnormal_embryonic-extraembry1.19431778
76MP0002066_abnormal_motor_capabilities/c1.18958503
77MP0003122_maternal_imprinting1.18311987
78MP0002751_abnormal_autonomic_nervous1.18258228
79MP0006292_abnormal_olfactory_placode1.17957241
80MP0003121_genomic_imprinting1.15952202
81MP0003724_increased_susceptibility_to1.14890201
82MP0002163_abnormal_gland_morphology1.14845218
83MP0008260_abnormal_autophagy1.13888757
84MP0009785_altered_susceptibility_to1.12030257
85MP0003937_abnormal_limbs/digits/tail_de1.11998895
86MP0008995_early_reproductive_senescence1.08781090
87MP0002148_abnormal_hypersensitivity_rea1.08580011
88MP0005499_abnormal_olfactory_system1.08329321
89MP0005394_taste/olfaction_phenotype1.08329321
90MP0000647_abnormal_sebaceous_gland1.07778009
91MP0001293_anophthalmia1.07567974
92MP0005084_abnormal_gallbladder_morpholo1.06869445
93MP0005187_abnormal_penis_morphology1.06542295
94MP0005195_abnormal_posterior_eye1.06016728
95MP0002882_abnormal_neuron_morphology1.05572911
96MP0002282_abnormal_trachea_morphology1.05244682
97MP0003938_abnormal_ear_development1.04537162
98MP0000015_abnormal_ear_pigmentation1.03728019
99MP0010678_abnormal_skin_adnexa1.03530091
100MP0001835_abnormal_antigen_presentation1.02710645
101MP0000049_abnormal_middle_ear1.02365549
102MP0003633_abnormal_nervous_system1.01558909
103MP0001919_abnormal_reproductive_system1.00689319
104MP0001502_abnormal_circadian_rhythm1.00400336
105MP0003950_abnormal_plasma_membrane1.00145461
106MP0001963_abnormal_hearing_physiology1.00113789
107MP0000955_abnormal_spinal_cord0.99696706
108MP0005551_abnormal_eye_electrophysiolog0.99463693
109MP0004811_abnormal_neuron_physiology0.99128845
110MP0001986_abnormal_taste_sensitivity0.98996002
111MP0008004_abnormal_stomach_pH0.98275025
112MP0001764_abnormal_homeostasis0.96761537
113MP0005645_abnormal_hypothalamus_physiol0.95650150
114MP0002277_abnormal_respiratory_mucosa0.95058916
115MP0002095_abnormal_skin_pigmentation0.92972483
116MP0005000_abnormal_immune_tolerance0.92938579
117MP0003631_nervous_system_phenotype0.92697581
118MP0009697_abnormal_copulation0.92387058
119MP0002928_abnormal_bile_duct0.92261906
120MP0005085_abnormal_gallbladder_physiolo0.91971139
121MP0002229_neurodegeneration0.91234053
122MP0003136_yellow_coat_color0.87128979
123MP0005367_renal/urinary_system_phenotyp0.86789958
124MP0000516_abnormal_urinary_system0.86789958
125MP0003634_abnormal_glial_cell0.86489220
126MP0002909_abnormal_adrenal_gland0.86333151
127MP0000613_abnormal_salivary_gland0.85782122
128MP0002752_abnormal_somatic_nervous0.83534566
129MP0005075_abnormal_melanosome_morpholog0.83443698
130MP0008877_abnormal_DNA_methylation0.83395577
131MP0003329_amyloid_beta_deposits0.83368767
132MP0005310_abnormal_salivary_gland0.83184071
133MP0002822_catalepsy0.82960298
134MP0008775_abnormal_heart_ventricle0.82248573
135MP0005332_abnormal_amino_acid0.81806318
136MP0001664_abnormal_digestion0.81267375
137MP0001485_abnormal_pinna_reflex0.81187268
138MP0002254_reproductive_system_inflammat0.80181863
139MP0008057_abnormal_DNA_replication0.78403345
140MP0001324_abnormal_eye_pigmentation0.77858842
141MP0005410_abnormal_fertilization0.76778775
142MP0003252_abnormal_bile_duct0.76379785
143MP0000372_irregular_coat_pigmentation0.76318397
144MP0003698_abnormal_male_reproductive0.76150746
145MP0005409_darkened_coat_color0.73396891
146MP0004484_altered_response_of0.71585318
147MP0003690_abnormal_glial_cell0.70495394
148MP0002069_abnormal_eating/drinking_beha0.69992308
149MP0000631_abnormal_neuroendocrine_gland0.69960708
150MP0000026_abnormal_inner_ear0.69058180
151MP0005379_endocrine/exocrine_gland_phen0.68216975
152MP0002419_abnormal_innate_immunity0.68101827
153MP0002152_abnormal_brain_morphology0.65441223
154MP0003303_peritoneal_inflammation0.65133680
155MP0005535_abnormal_body_temperature0.64449626
156MP0001542_abnormal_bone_strength0.63890493
157MP0000681_abnormal_thyroid_gland0.63456400
158MP0005387_immune_system_phenotype0.62731748
159MP0001790_abnormal_immune_system0.62731748
160MP0003632_abnormal_nervous_system0.61866539
161MP0008874_decreased_physiological_sensi0.61747938
162MP0004134_abnormal_chest_morphology0.60912317
163MP0002723_abnormal_immune_serum0.59983777
164MP0002009_preneoplasia0.58797891

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.81178064
2Atonic seizures (HP:0010819)6.23539546
3Hyperventilation (HP:0002883)5.19725136
4Epileptic encephalopathy (HP:0200134)4.98898000
5Pancreatic cysts (HP:0001737)4.60289964
6Febrile seizures (HP:0002373)4.52633290
7Focal seizures (HP:0007359)4.27382426
8Absence seizures (HP:0002121)4.22027008
9Abnormal hair whorl (HP:0010721)4.16828434
10Dialeptic seizures (HP:0011146)4.14383619
11True hermaphroditism (HP:0010459)4.12057458
12Molar tooth sign on MRI (HP:0002419)3.99746213
13Abnormality of midbrain morphology (HP:0002418)3.99746213
14Nephronophthisis (HP:0000090)3.86176488
15Acute necrotizing encephalopathy (HP:0006965)3.50933133
16Abnormality of the renal medulla (HP:0100957)3.27579333
17Diplopia (HP:0000651)3.22447447
18Abnormality of binocular vision (HP:0011514)3.22447447
19Abnormal mitochondria in muscle tissue (HP:0008316)3.18178767
20Mitochondrial inheritance (HP:0001427)3.16112230
21Congenital stationary night blindness (HP:0007642)3.13504030
22Broad-based gait (HP:0002136)3.09743105
23Abnormality of the renal cortex (HP:0011035)3.08483679
24Progressive macrocephaly (HP:0004481)3.03348149
25Protruding tongue (HP:0010808)3.01729214
26Sensory axonal neuropathy (HP:0003390)3.01664349
27Abnormality of glycolysis (HP:0004366)3.00822842
28Increased serum pyruvate (HP:0003542)3.00822842
29Progressive cerebellar ataxia (HP:0002073)2.97871227
30Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.95772819
31Generalized tonic-clonic seizures (HP:0002069)2.91616341
32Hepatocellular necrosis (HP:0001404)2.91214277
33Gait imbalance (HP:0002141)2.80615174
34Inability to walk (HP:0002540)2.80444876
35Cystic liver disease (HP:0006706)2.79293178
36Gaze-evoked nystagmus (HP:0000640)2.77747841
37Congenital, generalized hypertrichosis (HP:0004540)2.74807610
38Medial flaring of the eyebrow (HP:0010747)2.74337782
39Pheochromocytoma (HP:0002666)2.71921159
40Visual hallucinations (HP:0002367)2.70454854
41Abnormal respiratory motile cilium morphology (HP:0005938)2.69970205
42Abnormal respiratory epithelium morphology (HP:0012253)2.69970205
43Increased CSF lactate (HP:0002490)2.62888072
44Renal cortical cysts (HP:0000803)2.62682744
45Abolished electroretinogram (ERG) (HP:0000550)2.62132453
46Pendular nystagmus (HP:0012043)2.61183264
47Akinesia (HP:0002304)2.60888332
48Congenital primary aphakia (HP:0007707)2.60167042
49Progressive inability to walk (HP:0002505)2.59795510
50Methylmalonic acidemia (HP:0002912)2.58719047
51Neuroendocrine neoplasm (HP:0100634)2.58529563
52Nephrogenic diabetes insipidus (HP:0009806)2.54872432
53Polyphagia (HP:0002591)2.53539119
54Acute encephalopathy (HP:0006846)2.49403365
55Type II lissencephaly (HP:0007260)2.48734197
56Myokymia (HP:0002411)2.47849830
57Scanning speech (HP:0002168)2.46387748
58Absent speech (HP:0001344)2.44352404
59Abnormal ciliary motility (HP:0012262)2.44020552
60Attenuation of retinal blood vessels (HP:0007843)2.43392556
61Hypothermia (HP:0002045)2.43134675
62Sclerocornea (HP:0000647)2.39399926
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.34781421
64Chronic hepatic failure (HP:0100626)2.33704833
65Tubular atrophy (HP:0000092)2.32691671
66Furrowed tongue (HP:0000221)2.32290312
67Abnormal rod and cone electroretinograms (HP:0008323)2.32087561
68Poor suck (HP:0002033)2.30414000
69Aplasia/Hypoplasia of the tibia (HP:0005772)2.30229464
70Drooling (HP:0002307)2.30108452
71Excessive salivation (HP:0003781)2.30108452
72Abnormal respiratory motile cilium physiology (HP:0012261)2.28571696
73Large for gestational age (HP:0001520)2.26291632
74Epileptiform EEG discharges (HP:0011182)2.23987997
75Truncal ataxia (HP:0002078)2.21140436
76Abnormal eating behavior (HP:0100738)2.20726217
77Esotropia (HP:0000565)2.19432390
78Male pseudohermaphroditism (HP:0000037)2.19329070
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.18388532
80Postaxial foot polydactyly (HP:0001830)2.17790348
81Blue irides (HP:0000635)2.17770525
82Thyroid-stimulating hormone excess (HP:0002925)2.17207109
83Methylmalonic aciduria (HP:0012120)2.16664184
84Decreased central vision (HP:0007663)2.16356955
85Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.15399449
86Degeneration of the lateral corticospinal tracts (HP:0002314)2.15399449
87Abnormal biliary tract physiology (HP:0012439)2.12204732
88Bile duct proliferation (HP:0001408)2.12204732
89Increased corneal curvature (HP:0100692)2.11983061
90Keratoconus (HP:0000563)2.11983061
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11317799
92Abnormality of alanine metabolism (HP:0010916)2.11317799
93Hyperalaninemia (HP:0003348)2.11317799
94Congenital hepatic fibrosis (HP:0002612)2.10229252
95Hyperglycinemia (HP:0002154)2.09389966
96Clumsiness (HP:0002312)2.07704762
97Anencephaly (HP:0002323)2.07225715
98Absent rod-and cone-mediated responses on ERG (HP:0007688)2.05069856
99Aplasia/Hypoplasia of the spleen (HP:0010451)2.02930176
100Retinal dysplasia (HP:0007973)2.02797433
101Generalized myoclonic seizures (HP:0002123)2.02500257
102Poor eye contact (HP:0000817)2.02100241
103Increased neuronal autofluorescent lipopigment (HP:0002074)2.01244579
104Aplasia/hypoplasia of the uterus (HP:0008684)1.99923183
105Parakeratosis (HP:0001036)1.98973544
106Short tibia (HP:0005736)1.97637210
107Stomach cancer (HP:0012126)1.95551534
108Submucous cleft hard palate (HP:0000176)1.95041023
109Optic disc pallor (HP:0000543)1.94612710
110Cerebellar dysplasia (HP:0007033)1.93989568
111Lipid accumulation in hepatocytes (HP:0006561)1.93591727
112Dysmetria (HP:0001310)1.92935407
113Rhinitis (HP:0012384)1.92867759
114Asplenia (HP:0001746)1.92555037
115Fetal akinesia sequence (HP:0001989)1.90733380
116Poor coordination (HP:0002370)1.88791850
117Hyperglycinuria (HP:0003108)1.88413735
118Increased hepatocellular lipid droplets (HP:0006565)1.88319297
119Lissencephaly (HP:0001339)1.87961524
120Heterochromia iridis (HP:0001100)1.87384674
121Autoamputation (HP:0001218)1.87230224
122Postaxial hand polydactyly (HP:0001162)1.87082178
123Widely spaced teeth (HP:0000687)1.86870270
124Polydipsia (HP:0001959)1.86199086
125Abnormal drinking behavior (HP:0030082)1.86199086
126Fair hair (HP:0002286)1.85276598
127Leukodystrophy (HP:0002415)1.85074636
128Genital tract atresia (HP:0001827)1.85029761
129Abnormality of salivation (HP:0100755)1.83525173
130Bilateral microphthalmos (HP:0007633)1.83464204
131Abnormality of glycine metabolism (HP:0010895)1.83045078
132Abnormality of serine family amino acid metabolism (HP:0010894)1.83045078
133Congenital ichthyosiform erythroderma (HP:0007431)1.82353265
134Vaginal atresia (HP:0000148)1.82250799
135Cerebral hypomyelination (HP:0006808)1.82095588
136EEG with generalized epileptiform discharges (HP:0011198)1.81489819
137Absent/shortened dynein arms (HP:0200106)1.81025044
138Dynein arm defect of respiratory motile cilia (HP:0012255)1.81025044
139Hepatic necrosis (HP:0002605)1.80835129
140Concave nail (HP:0001598)1.80620423
141Impaired vibration sensation in the lower limbs (HP:0002166)1.80394857
142Generalized hypopigmentation of hair (HP:0011358)1.79466359
143Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78832051
144Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77775285
145Chorioretinal atrophy (HP:0000533)1.76138683
146Specific learning disability (HP:0001328)1.75125575
147Abnormality of the labia minora (HP:0012880)1.75024163
148Intestinal atresia (HP:0011100)1.74667639
149Dysdiadochokinesis (HP:0002075)1.73619536
150Preaxial hand polydactyly (HP:0001177)1.73167495
151Hypoplasia of the uterus (HP:0000013)1.72258028
152Stomatitis (HP:0010280)1.72243933
153X-linked dominant inheritance (HP:0001423)1.71277614
154Optic nerve hypoplasia (HP:0000609)1.69585728
155Thickened helices (HP:0000391)1.69203446
156Pancreatic fibrosis (HP:0100732)1.68860405
157Aplasia/Hypoplasia of the uvula (HP:0010293)1.68835012
158Increased serum lactate (HP:0002151)1.67625664
159Amblyopia (HP:0000646)1.67537739
160Abnormality of macular pigmentation (HP:0008002)1.67287839
161Anophthalmia (HP:0000528)1.67004122
162Diminished movement (HP:0002374)1.65833839
163Respiratory failure (HP:0002878)1.63758336
164Increased cerebral lipofuscin (HP:0011813)1.63572685
165Failure to thrive in infancy (HP:0001531)1.62805569
166Hypsarrhythmia (HP:0002521)1.62185608
167Aplasia/Hypoplasia of the lens (HP:0008063)1.60311440
1683-Methylglutaconic aciduria (HP:0003535)1.59930598
169Recurrent abscess formation (HP:0002722)1.59744396

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.91809127
2FRK5.03852242
3MAP3K124.73229861
4MAP2K73.22564956
5MAP4K23.05526659
6ZAK3.02394335
7GRK12.80135421
8CDK192.75797060
9WNK32.69739037
10TNIK2.61232784
11EPHA42.53590638
12TLK12.53212691
13ACVR1B2.51730429
14AKT32.40598529
15NUAK12.34347070
16PLK22.32900322
17MAP3K42.15988869
18PRPF4B2.06759635
19OXSR12.03214996
20RIPK42.02065793
21CCNB12.01997284
22PINK11.95473797
23BMPR21.87213162
24TAOK31.85263904
25NTRK31.85166948
26TSSK61.81705382
27WNK41.66261232
28DAPK11.59628098
29STK161.56914752
30TRIM281.55827850
31BCR1.50892891
32MST41.46117306
33MARK11.41997674
34ADRBK21.39914728
35TXK1.37788276
36SIK31.34684682
37MAPK131.30421301
38TGFBR11.29481718
39MAP2K41.29147545
40FES1.27852875
41DAPK21.19075311
42BMPR1B1.17057735
43MINK11.14438954
44YES11.12681641
45BRSK21.05763129
46TIE11.03661898
47MUSK1.02575897
48MAP3K141.01261103
49STK38L1.00805572
50NME10.99807156
51VRK20.99789958
52BCKDK0.98959449
53FGFR20.98404986
54CSNK1G10.95719483
55GRK50.93941372
56CAMK2B0.92720625
57SGK20.92193950
58GRK70.91771726
59PLK40.91382526
60CAMK2A0.90372161
61MYLK0.89887710
62PRKCG0.89463499
63TAF10.87658251
64SGK2230.86243081
65SGK4940.86243081
66PRKCE0.84788282
67KIT0.84559937
68CDK50.84152105
69NEK10.83333258
70NEK60.82943595
71STK390.80750500
72CAMKK20.80658156
73FLT30.78110068
74PAK30.77347141
75MKNK20.76574909
76CSNK1G20.73700621
77BRAF0.72247100
78FGR0.71263722
79ERBB30.71185815
80PBK0.69543036
81CSNK1G30.69411180
82INSRR0.68241513
83WEE10.67484925
84MAPK150.64494377
85PKN10.64099561
86STK30.63145336
87PIK3CA0.62402661
88PHKG20.62211471
89PHKG10.62211471
90NTRK20.60818201
91EIF2AK10.60537675
92PLK10.59206315
93SYK0.58939156
94SRPK10.58232184
95CDK30.58001569
96CSNK1A1L0.57395049
97CDK180.57014358
98ARAF0.55178941
99RPS6KA50.55066052
100ADRBK10.53935735
101MAPKAPK50.53639068
102CDK140.53000011
103DYRK1A0.52664368
104MAPKAPK30.50475813
105TNK20.50452172
106PNCK0.50435053
107CSNK1A10.50060636
108PTK2B0.49710209
109RAF10.48562593
110BUB10.48310780
111ATR0.48172663
112DYRK20.47898261
113ROCK20.47630127
114VRK10.47569907
115CDK150.47524185
116KSR10.46963931
117PLK30.46467050
118FYN0.45945094
119IKBKB0.45340364
120LIMK10.44052729
121CDC70.42701108
122PASK0.42651549
123IRAK40.42204078
124EIF2AK20.42028590
125CHEK20.41803151
126CAMK2D0.41659332
127EPHA30.41530645
128PRKCQ0.41113136
129LYN0.40108479
130CDK11A0.39841822
131PRKACA0.39082712
132MKNK10.38888035
133MAP2K60.38691501
134ERBB40.38688619
135CDK80.38463866
136LCK0.37060586
137NEK20.36846579
138RPS6KA40.36215816
139ATM0.35689107
140PRKCH0.35063818
141PRKG10.35051613
142EIF2AK30.34790270
143SGK10.34340271
144MAP3K60.33906424
145PDK20.33222119
146PRKCI0.33000948
147DYRK30.31397825
148ERBB20.30982385
149PDK30.30661713
150PDK40.30661713
151TEC0.30523645
152PIM20.30412887
153TTK0.30180052
154IGF1R0.29582592
155CSNK2A10.28693516
156PRKCA0.28274960

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.97919218
2Collecting duct acid secretion_Homo sapiens_hsa049663.69267523
3Synaptic vesicle cycle_Homo sapiens_hsa047213.31514190
4Rheumatoid arthritis_Homo sapiens_hsa053232.57205017
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.51620313
6Vibrio cholerae infection_Homo sapiens_hsa051102.47954095
7Type I diabetes mellitus_Homo sapiens_hsa049402.45956813
8Oxidative phosphorylation_Homo sapiens_hsa001902.38504602
9Graft-versus-host disease_Homo sapiens_hsa053322.33577871
10Nitrogen metabolism_Homo sapiens_hsa009102.29511260
11Morphine addiction_Homo sapiens_hsa050322.26239830
12Linoleic acid metabolism_Homo sapiens_hsa005912.18574897
13Maturity onset diabetes of the young_Homo sapiens_hsa049502.16986419
14Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051202.14325682
15GABAergic synapse_Homo sapiens_hsa047272.14073698
16Caffeine metabolism_Homo sapiens_hsa002322.13742048
17Homologous recombination_Homo sapiens_hsa034402.09064846
18Butanoate metabolism_Homo sapiens_hsa006502.07604711
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.01685993
20Allograft rejection_Homo sapiens_hsa053301.96222859
21Selenocompound metabolism_Homo sapiens_hsa004501.95951163
22Long-term potentiation_Homo sapiens_hsa047201.89071368
23Fanconi anemia pathway_Homo sapiens_hsa034601.87012527
24Circadian entrainment_Homo sapiens_hsa047131.86048356
25Basal transcription factors_Homo sapiens_hsa030221.83347732
26alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.82435030
27Glutamatergic synapse_Homo sapiens_hsa047241.82143944
28Olfactory transduction_Homo sapiens_hsa047401.81735887
29RNA degradation_Homo sapiens_hsa030181.76598802
30Serotonergic synapse_Homo sapiens_hsa047261.73767884
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.70370272
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.67106639
33Phagosome_Homo sapiens_hsa041451.59090999
34Amphetamine addiction_Homo sapiens_hsa050311.59053819
35Propanoate metabolism_Homo sapiens_hsa006401.54050558
36Dopaminergic synapse_Homo sapiens_hsa047281.53443048
37Tryptophan metabolism_Homo sapiens_hsa003801.52158908
38Long-term depression_Homo sapiens_hsa047301.45821725
39Proteasome_Homo sapiens_hsa030501.43827372
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.43258924
41Taste transduction_Homo sapiens_hsa047421.42202462
42SNARE interactions in vesicular transport_Homo sapiens_hsa041301.42109908
43Alzheimers disease_Homo sapiens_hsa050101.41940597
44Protein export_Homo sapiens_hsa030601.40424836
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.38644336
46Parkinsons disease_Homo sapiens_hsa050121.37336485
47Chemical carcinogenesis_Homo sapiens_hsa052041.36080477
48Peroxisome_Homo sapiens_hsa041461.33110611
49One carbon pool by folate_Homo sapiens_hsa006701.29144066
50Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.26803988
51African trypanosomiasis_Homo sapiens_hsa051431.25424122
52Primary bile acid biosynthesis_Homo sapiens_hsa001201.23719448
53Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.22842180
54Sulfur metabolism_Homo sapiens_hsa009201.17515354
55Salivary secretion_Homo sapiens_hsa049701.15799592
56Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.14737748
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.14593976
58Renin secretion_Homo sapiens_hsa049241.14495522
59Calcium signaling pathway_Homo sapiens_hsa040201.14135230
60Retinol metabolism_Homo sapiens_hsa008301.12765606
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12170529
62Cholinergic synapse_Homo sapiens_hsa047251.10118747
63Ribosome_Homo sapiens_hsa030101.01983940
64Non-homologous end-joining_Homo sapiens_hsa034501.01668946
65Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01353723
66Cocaine addiction_Homo sapiens_hsa050300.97877295
67Phototransduction_Homo sapiens_hsa047440.95306470
68Regulation of autophagy_Homo sapiens_hsa041400.95000714
69Insulin secretion_Homo sapiens_hsa049110.93065952
70Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92340257
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92227352
72Purine metabolism_Homo sapiens_hsa002300.91263338
73Autoimmune thyroid disease_Homo sapiens_hsa053200.91086626
74Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.90919350
75Arachidonic acid metabolism_Homo sapiens_hsa005900.88220435
76Oxytocin signaling pathway_Homo sapiens_hsa049210.86477259
77Sphingolipid metabolism_Homo sapiens_hsa006000.86275362
78Huntingtons disease_Homo sapiens_hsa050160.85710049
79Steroid biosynthesis_Homo sapiens_hsa001000.85049319
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.83106995
81Nucleotide excision repair_Homo sapiens_hsa034200.81612735
82Mismatch repair_Homo sapiens_hsa034300.81576551
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80790640
84ABC transporters_Homo sapiens_hsa020100.80453898
85Fat digestion and absorption_Homo sapiens_hsa049750.80211822
86Pyrimidine metabolism_Homo sapiens_hsa002400.78395827
87Cysteine and methionine metabolism_Homo sapiens_hsa002700.77863229
88Tuberculosis_Homo sapiens_hsa051520.76635177
89Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76326770
90Glycerolipid metabolism_Homo sapiens_hsa005610.76044258
91Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75446141
92Axon guidance_Homo sapiens_hsa043600.74507429
93Salmonella infection_Homo sapiens_hsa051320.73664391
94Metabolic pathways_Homo sapiens_hsa011000.72926220
95Gastric acid secretion_Homo sapiens_hsa049710.70275819
96Vitamin digestion and absorption_Homo sapiens_hsa049770.69270692
97beta-Alanine metabolism_Homo sapiens_hsa004100.68585499
98Ether lipid metabolism_Homo sapiens_hsa005650.68227175
99T cell receptor signaling pathway_Homo sapiens_hsa046600.68116965
100RNA transport_Homo sapiens_hsa030130.66881218
101Malaria_Homo sapiens_hsa051440.66555880
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66289625
103cAMP signaling pathway_Homo sapiens_hsa040240.64033098
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64027604
105Aldosterone synthesis and secretion_Homo sapiens_hsa049250.62955416
106Fatty acid elongation_Homo sapiens_hsa000620.62444132
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.61455044
108Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.60407624
109Histidine metabolism_Homo sapiens_hsa003400.60134635
110ErbB signaling pathway_Homo sapiens_hsa040120.60087334
111Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.58563632
112Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56806151
113RNA polymerase_Homo sapiens_hsa030200.56512070
114Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55912632
115Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.54900584
116Gap junction_Homo sapiens_hsa045400.54740956
117Leishmaniasis_Homo sapiens_hsa051400.53903040
118Hematopoietic cell lineage_Homo sapiens_hsa046400.53459111
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53322246
120Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52517258
121Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52088153
122Lysosome_Homo sapiens_hsa041420.51322660
123Chemokine signaling pathway_Homo sapiens_hsa040620.51248855
124p53 signaling pathway_Homo sapiens_hsa041150.51153661
125Asthma_Homo sapiens_hsa053100.49916432
126MAPK signaling pathway_Homo sapiens_hsa040100.49742850
127Circadian rhythm_Homo sapiens_hsa047100.49508462
128Mineral absorption_Homo sapiens_hsa049780.49355614
129Glutathione metabolism_Homo sapiens_hsa004800.48845845
130Cardiac muscle contraction_Homo sapiens_hsa042600.48131853
131NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47423442
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47393300
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47348061
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.47209408
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.46806707
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46759652
137Ras signaling pathway_Homo sapiens_hsa040140.46019720
138Measles_Homo sapiens_hsa051620.45731754
139Pyruvate metabolism_Homo sapiens_hsa006200.44197351
140Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43927573
141Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.43074991
142Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.39704135
143GnRH signaling pathway_Homo sapiens_hsa049120.39476168
144Antigen processing and presentation_Homo sapiens_hsa046120.39364833
145Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38803097
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.38135420
147Hedgehog signaling pathway_Homo sapiens_hsa043400.38084825
148Primary immunodeficiency_Homo sapiens_hsa053400.37563724
149Ovarian steroidogenesis_Homo sapiens_hsa049130.37432325
150Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37280148
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36417616
152Shigellosis_Homo sapiens_hsa051310.35811503
153Legionellosis_Homo sapiens_hsa051340.35463729
154Fatty acid degradation_Homo sapiens_hsa000710.34572415
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34199087
156Toll-like receptor signaling pathway_Homo sapiens_hsa046200.34082638
157Drug metabolism - other enzymes_Homo sapiens_hsa009830.33167569
158Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32597958
159Pertussis_Homo sapiens_hsa051330.32314223
160Other glycan degradation_Homo sapiens_hsa005110.32136042
161Osteoclast differentiation_Homo sapiens_hsa043800.31140531
162Endocytosis_Homo sapiens_hsa041440.30959967

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