TMEM63C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06623952
2synaptic vesicle maturation (GO:0016188)5.94593454
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.68172116
4locomotory exploration behavior (GO:0035641)5.45507388
5synaptic vesicle exocytosis (GO:0016079)5.45380268
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.34343988
7glutamate secretion (GO:0014047)5.17536755
8regulation of synaptic vesicle exocytosis (GO:2000300)5.10087612
9vocalization behavior (GO:0071625)5.06361933
10synaptic vesicle docking involved in exocytosis (GO:0016081)4.87519294
11neuronal action potential propagation (GO:0019227)4.84761026
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.78554256
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.60594252
14neurotransmitter secretion (GO:0007269)4.53566763
15regulation of synaptic vesicle transport (GO:1902803)4.50842953
16regulation of glutamate receptor signaling pathway (GO:1900449)4.47283048
17protein localization to synapse (GO:0035418)4.44515482
18cellular potassium ion homeostasis (GO:0030007)4.44466558
19cerebellar Purkinje cell differentiation (GO:0021702)4.27269609
20exploration behavior (GO:0035640)4.24978829
21synaptic transmission, glutamatergic (GO:0035249)4.22553482
22sodium ion export (GO:0071436)4.16174340
23glutamate receptor signaling pathway (GO:0007215)4.15855736
24regulation of ARF protein signal transduction (GO:0032012)4.12968929
25neuronal ion channel clustering (GO:0045161)4.10811670
26regulation of synapse maturation (GO:0090128)4.10164256
27membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.09551215
28regulation of neuronal synaptic plasticity (GO:0048168)4.08974477
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.01198372
30gamma-aminobutyric acid transport (GO:0015812)4.00599774
31regulation of synapse structural plasticity (GO:0051823)3.99548253
32neuron cell-cell adhesion (GO:0007158)3.98869148
33neuron-neuron synaptic transmission (GO:0007270)3.98763526
34membrane depolarization during action potential (GO:0086010)3.96625615
35regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.95329280
36regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95143141
37proline transport (GO:0015824)3.94499464
38neuromuscular process controlling posture (GO:0050884)3.94319726
39postsynaptic membrane organization (GO:0001941)3.90779353
40response to pheromone (GO:0019236)3.89744895
41layer formation in cerebral cortex (GO:0021819)3.88922615
42positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.85496725
43regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.85310685
44neurotransmitter-gated ion channel clustering (GO:0072578)3.79475936
45long-term memory (GO:0007616)3.72241245
46positive regulation of synapse maturation (GO:0090129)3.68888907
47regulation of excitatory postsynaptic membrane potential (GO:0060079)3.68333322
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.67451543
49L-amino acid import (GO:0043092)3.65400955
50neurotransmitter transport (GO:0006836)3.65252540
51positive regulation of membrane potential (GO:0045838)3.63943064
52cerebellar granule cell differentiation (GO:0021707)3.58981387
53regulation of postsynaptic membrane potential (GO:0060078)3.57638560
54dendritic spine organization (GO:0097061)3.52225720
55positive regulation of neurotransmitter secretion (GO:0001956)3.51123259
56regulation of neurotransmitter secretion (GO:0046928)3.49205216
57neuromuscular process controlling balance (GO:0050885)3.47689388
58synaptic vesicle endocytosis (GO:0048488)3.47061550
59gamma-aminobutyric acid signaling pathway (GO:0007214)3.44938629
60positive regulation of neurotransmitter transport (GO:0051590)3.44045129
61cell communication by electrical coupling (GO:0010644)3.43291264
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42218316
63activation of protein kinase A activity (GO:0034199)3.41421461
64membrane hyperpolarization (GO:0060081)3.39857879
65regulation of synaptic plasticity (GO:0048167)3.39790395
66membrane depolarization (GO:0051899)3.38744400
67transmission of nerve impulse (GO:0019226)3.38690478
68regulation of neurotransmitter levels (GO:0001505)3.37012747
69regulation of synaptic transmission, glutamatergic (GO:0051966)3.34847951
70cytoskeletal anchoring at plasma membrane (GO:0007016)3.34410381
71positive regulation of dendritic spine development (GO:0060999)3.32208970
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.31395192
73amino acid import (GO:0043090)3.30913406
74dendritic spine morphogenesis (GO:0060997)3.29984029
75cerebellar Purkinje cell layer development (GO:0021680)3.28318227
76long-term synaptic potentiation (GO:0060291)3.27109287
77positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.26061046
78calcium ion-dependent exocytosis (GO:0017156)3.25962093
79prepulse inhibition (GO:0060134)3.25865589
80innervation (GO:0060384)3.24936293
81regulation of neurotransmitter transport (GO:0051588)3.21257391
82regulation of vesicle fusion (GO:0031338)3.21135976
83positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.20939889
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20771921
85positive regulation of dendritic spine morphogenesis (GO:0061003)3.19681769
86positive regulation of potassium ion transmembrane transport (GO:1901381)3.19679000
87dendrite morphogenesis (GO:0048813)3.19061240
88negative regulation of synaptic transmission, GABAergic (GO:0032229)3.15485199
89vesicle transport along microtubule (GO:0047496)3.15342616
90cellular sodium ion homeostasis (GO:0006883)3.15154624
91glycine transport (GO:0015816)3.14471355
92auditory behavior (GO:0031223)3.10618088
93cell differentiation in hindbrain (GO:0021533)3.10524362
94regulation of female receptivity (GO:0045924)3.08442485
95response to auditory stimulus (GO:0010996)3.07986568
96negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.07145767
97regulation of calcium ion-dependent exocytosis (GO:0017158)3.05986708
98central nervous system myelination (GO:0022010)3.04689951
99axon ensheathment in central nervous system (GO:0032291)3.04689951
100neuromuscular process (GO:0050905)3.04111659
101signal release (GO:0023061)3.04014014
102cell migration in hindbrain (GO:0021535)3.03887346
103regulation of dendritic spine morphogenesis (GO:0061001)3.03357501
104synapse assembly (GO:0007416)3.03208642
105neuromuscular synaptic transmission (GO:0007274)3.02536036
106synaptic transmission (GO:0007268)3.02378357
107cell communication involved in cardiac conduction (GO:0086065)3.01940530
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01749552
109axonal fasciculation (GO:0007413)3.00720867
110presynaptic membrane organization (GO:0097090)2.97626829
111potassium ion homeostasis (GO:0055075)2.96970393
112chemosensory behavior (GO:0007635)2.96487177
113neuronal action potential (GO:0019228)2.95929056
114regulation of voltage-gated calcium channel activity (GO:1901385)2.95568142
115mating behavior (GO:0007617)2.95040535
116mechanosensory behavior (GO:0007638)2.94600449
117neuron recognition (GO:0008038)2.93584022
118regulation of synaptic transmission (GO:0050804)2.92852818
119negative regulation of dendrite morphogenesis (GO:0050774)2.92598220
120potassium ion import (GO:0010107)2.91724935
121behavioral defense response (GO:0002209)2.91439374
122behavioral fear response (GO:0001662)2.91439374
123adult walking behavior (GO:0007628)2.91187381
124regulation of exocytosis (GO:0017157)2.90968536
125presynaptic membrane assembly (GO:0097105)2.90901060
126cerebellum development (GO:0021549)2.89731366
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.88796556

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.49701017
2GBX2_23144817_ChIP-Seq_PC3_Human3.36865328
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07616315
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.00211735
5* REST_21632747_ChIP-Seq_MESCs_Mouse2.92977420
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.88381361
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.64339725
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.64339725
9DROSHA_22980978_ChIP-Seq_HELA_Human2.60140821
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.58278115
11RARB_27405468_Chip-Seq_BRAIN_Mouse2.57776964
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52841825
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.51889775
14SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.46957778
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43110975
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.42870484
17* REST_18959480_ChIP-ChIP_MESCs_Mouse2.40176471
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.38989265
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.30558708
20ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.26058421
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.23250627
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22201061
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19056576
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.12056391
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.11153332
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09154005
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.05620823
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.05176457
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.00008975
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.99377746
31AR_21572438_ChIP-Seq_LNCaP_Human1.71035720
32* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.66071262
33* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65653035
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.65031192
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.59784861
36ZNF274_21170338_ChIP-Seq_K562_Hela1.53437288
37ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49759644
38TAF15_26573619_Chip-Seq_HEK293_Human1.49640461
39ESR2_21235772_ChIP-Seq_MCF-7_Human1.47270128
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43390248
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.42812652
42TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.42710002
43LXR_22292898_ChIP-Seq_THP-1_Human1.42073948
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.39456514
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.35672950
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31907148
47SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31368603
48OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.31242439
49SOX2_21211035_ChIP-Seq_LN229_Gbm1.28736978
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27093713
51ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26605794
52STAT3_23295773_ChIP-Seq_U87_Human1.26257904
53* AR_19668381_ChIP-Seq_PC3_Human1.25310256
54DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24999882
55RING1B_27294783_Chip-Seq_ESCs_Mouse1.22117401
56AR_25329375_ChIP-Seq_VCAP_Human1.22088554
57SMC4_20622854_ChIP-Seq_HELA_Human1.17563217
58P300_19829295_ChIP-Seq_ESCs_Human1.16974883
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.15843075
60TP53_20018659_ChIP-ChIP_R1E_Mouse1.14848057
61KDM2B_26808549_Chip-Seq_K562_Human1.14529516
62PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14249118
63WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14000789
64BMI1_23680149_ChIP-Seq_NPCS_Mouse1.13305931
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.13210454
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12333607
67CREB1_26743006_Chip-Seq_LNCaP_Human1.12082320
68P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11376131
69PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11000175
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.10850161
71TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10026315
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09316516
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09161152
74* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08727328
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07953188
76TCF4_23295773_ChIP-Seq_U87_Human1.06872671
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.06310490
78OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06308143
79TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05313057
80IGF1R_20145208_ChIP-Seq_DFB_Human1.04787071
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04079590
82KDM2B_26808549_Chip-Seq_DND41_Human1.03877949
83TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03706211
84OCT4_19829295_ChIP-Seq_ESCs_Human1.03658809
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.03314259
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03126870
87MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02756283
88GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02393475
89RNF2_27304074_Chip-Seq_NSC_Mouse1.02063364
90ZFP281_18757296_ChIP-ChIP_E14_Mouse1.01744323
91AHR_22903824_ChIP-Seq_MCF-7_Human1.00786032
92RING1B_27294783_Chip-Seq_NPCs_Mouse1.00713841
93GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00039105
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99904620
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.99064724
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98845871
97ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98275032
98PIAS1_25552417_ChIP-Seq_VCAP_Human0.97328584
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.97139346
100ARNT_22903824_ChIP-Seq_MCF-7_Human0.97101693
101SMAD4_21741376_ChIP-Seq_HESCs_Human0.96326929
102SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96141980
103CDX2_19796622_ChIP-Seq_MESCs_Mouse0.95370494
104* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92884446
105RUNX2_22187159_ChIP-Seq_PCA_Human0.92029668
106DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91991715
107CTCF_27219007_Chip-Seq_Bcells_Human0.91501431
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.90474987
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89914513
110SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.89774982
111VDR_22108803_ChIP-Seq_LS180_Human0.88367485
112* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88307561
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.87951415
114CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.87536156
115SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86684212
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86213472
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.86163280
118PRDM14_20953172_ChIP-Seq_ESCs_Human0.85681230
119NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85567417
120P68_20966046_ChIP-Seq_HELA_Human0.85425440
121KLF4_19829295_ChIP-Seq_ESCs_Human0.84899102
122RXR_22108803_ChIP-Seq_LS180_Human0.84504027
123CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84433701
124SMAD4_21741376_ChIP-Seq_EPCs_Human0.84430839
125SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.84296996
126RACK7_27058665_Chip-Seq_MCF-7_Human0.84279779
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83569033
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83569033
129DPY_21335234_ChIP-Seq_ESCs_Mouse0.82455789
130SMAD4_21741376_ChIP-Seq_ESCs_Human0.80365414
131UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78025923
132TP63_17297297_ChIP-ChIP_HaCaT_Human0.77999138
133MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76813982
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.76638512
135NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.75992971
136STAT6_21828071_ChIP-Seq_BEAS2B_Human0.75449059
137KDM2B_26808549_Chip-Seq_JURKAT_Human0.74705886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.05808238
2MP0003635_abnormal_synaptic_transmissio4.02808371
3MP0003880_abnormal_central_pattern3.99674905
4MP0001968_abnormal_touch/_nociception3.88583838
5MP0004270_analgesia3.84894819
6MP0009046_muscle_twitch3.59520438
7MP0002735_abnormal_chemical_nociception3.26939893
8MP0009745_abnormal_behavioral_response3.24119366
9MP0002063_abnormal_learning/memory/cond3.14219045
10MP0002064_seizures3.07262555
11MP0002736_abnormal_nociception_after3.05167216
12MP0002734_abnormal_mechanical_nocicepti3.03894012
13MP0002272_abnormal_nervous_system2.81142226
14MP0005423_abnormal_somatic_nervous2.69878345
15MP0002572_abnormal_emotion/affect_behav2.68475309
16MP0002822_catalepsy2.57070132
17MP0002733_abnormal_thermal_nociception2.53720398
18MP0001486_abnormal_startle_reflex2.37377227
19MP0001970_abnormal_pain_threshold2.29924759
20MP0002067_abnormal_sensory_capabilities2.18131191
21MP0003123_paternal_imprinting2.16940704
22MP0004858_abnormal_nervous_system2.16885258
23MP0008569_lethality_at_weaning2.15299642
24MP0001501_abnormal_sleep_pattern2.12902016
25MP0002184_abnormal_innervation2.04004853
26MP0001440_abnormal_grooming_behavior2.02094780
27MP0006276_abnormal_autonomic_nervous1.96611318
28MP0003329_amyloid_beta_deposits1.83622103
29MP0001984_abnormal_olfaction1.79977105
30MP0004811_abnormal_neuron_physiology1.79853976
31MP0002909_abnormal_adrenal_gland1.77820552
32MP0005646_abnormal_pituitary_gland1.76058978
33MP0002557_abnormal_social/conspecific_i1.70688292
34MP0004924_abnormal_behavior1.69304603
35MP0005386_behavior/neurological_phenoty1.69304603
36MP0003879_abnormal_hair_cell1.66435153
37MP0009780_abnormal_chondrocyte_physiolo1.66057251
38MP0005645_abnormal_hypothalamus_physiol1.62796845
39MP0000955_abnormal_spinal_cord1.59954681
40MP0000778_abnormal_nervous_system1.51900690
41MP0002882_abnormal_neuron_morphology1.41748991
42MP0002066_abnormal_motor_capabilities/c1.41653198
43MP0003633_abnormal_nervous_system1.37801172
44MP0000579_abnormal_nail_morphology1.37766101
45MP0004142_abnormal_muscle_tone1.34126103
46MP0001502_abnormal_circadian_rhythm1.32105554
47MP0004145_abnormal_muscle_electrophysio1.31076852
48MP0004885_abnormal_endolymph1.29391441
49MP0003787_abnormal_imprinting1.28679046
50MP0003122_maternal_imprinting1.25869240
51MP0010386_abnormal_urinary_bladder1.17823812
52MP0003631_nervous_system_phenotype1.14323406
53MP0005409_darkened_coat_color1.12632531
54MP0008872_abnormal_physiological_respon1.09095887
55MP0003121_genomic_imprinting1.08615750
56MP0005551_abnormal_eye_electrophysiolog1.07813793
57MP0002229_neurodegeneration1.06282655
58MP0010234_abnormal_vibrissa_follicle1.02707253
59MP0002152_abnormal_brain_morphology1.01898366
60MP0001986_abnormal_taste_sensitivity1.01468558
61MP0003283_abnormal_digestive_organ1.00884981
62MP0000569_abnormal_digit_pigmentation0.99999311
63MP0001529_abnormal_vocalization0.96139243
64MP0008961_abnormal_basal_metabolism0.95230926
65MP0000751_myopathy0.93920898
66MP0002069_abnormal_eating/drinking_beha0.92017196
67MP0000566_synostosis0.91818205
68MP0008874_decreased_physiological_sensi0.89047831
69MP0004742_abnormal_vestibular_system0.88681428
70MP0001905_abnormal_dopamine_level0.86327614
71MP0004085_abnormal_heartbeat0.83548199
72MP0003632_abnormal_nervous_system0.82799060
73MP0001348_abnormal_lacrimal_gland0.82564245
74MP0000604_amyloidosis0.80815490
75MP0003634_abnormal_glial_cell0.79859580
76MP0001188_hyperpigmentation0.79297911
77MP0004233_abnormal_muscle_weight0.78526350
78MP0002638_abnormal_pupillary_reflex0.78498311
79MP0005535_abnormal_body_temperature0.78047029
80MP0004215_abnormal_myocardial_fiber0.77416928
81MP0000013_abnormal_adipose_tissue0.77374380
82MP0008877_abnormal_DNA_methylation0.75303188
83MP0002752_abnormal_somatic_nervous0.75050474
84MP0003861_abnormal_nervous_system0.74693519
85MP0001944_abnormal_pancreas_morphology0.74368867
86MP0003878_abnormal_ear_physiology0.74001356
87MP0005377_hearing/vestibular/ear_phenot0.74001356
88MP0001963_abnormal_hearing_physiology0.73963572
89MP0001765_abnormal_ion_homeostasis0.71671379
90MP0005499_abnormal_olfactory_system0.70468766
91MP0005394_taste/olfaction_phenotype0.70468766
92MP0005410_abnormal_fertilization0.70291728
93MP0003137_abnormal_impulse_conducting0.69468958
94MP0001299_abnormal_eye_distance/0.69058356
95MP0001177_atelectasis0.68397089
96MP0000920_abnormal_myelination0.67961273
97MP0003690_abnormal_glial_cell0.67502687
98MP0002249_abnormal_larynx_morphology0.66754130
99MP0010770_preweaning_lethality0.65618102
100MP0002082_postnatal_lethality0.65618102
101MP0003172_abnormal_lysosome_physiology0.64212354
102MP0003938_abnormal_ear_development0.64198188
103MP0000631_abnormal_neuroendocrine_gland0.64137672
104MP0002090_abnormal_vision0.64126975
105MP0004043_abnormal_pH_regulation0.63857189
106MP0003183_abnormal_peptide_metabolism0.63748084
107MP0003075_altered_response_to0.63407864
108MP0010768_mortality/aging0.63251212
109MP0000026_abnormal_inner_ear0.63158553
110MP0002837_dystrophic_cardiac_calcinosis0.62230479
111MP0001346_abnormal_lacrimal_gland0.58075709
112MP0001731_abnormal_postnatal_growth0.55658107
113MP0002653_abnormal_ependyma_morphology0.54979024
114MP0002876_abnormal_thyroid_physiology0.54514843
115MP0005448_abnormal_energy_balance0.54060302
116MP0003045_fibrosis0.53463129
117MP0002928_abnormal_bile_duct0.53426570
118MP0001664_abnormal_digestion0.53347608
119MP0010769_abnormal_survival0.52604229
120MP0003956_abnormal_body_size0.52299572
121MP0001485_abnormal_pinna_reflex0.51862148
122MP0001943_abnormal_respiration0.51406851
123MP0006072_abnormal_retinal_apoptosis0.51310769
124MP0004510_myositis0.51310603

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.31086066
2Myokymia (HP:0002411)6.92996880
3Focal seizures (HP:0007359)5.90824266
4Visual hallucinations (HP:0002367)5.33231947
5Action tremor (HP:0002345)5.24475437
6Progressive cerebellar ataxia (HP:0002073)5.04675798
7Febrile seizures (HP:0002373)4.83541545
8Epileptic encephalopathy (HP:0200134)4.79710993
9Atonic seizures (HP:0010819)4.61249231
10Obstructive sleep apnea (HP:0002870)4.51816818
11Absence seizures (HP:0002121)4.22383479
12Generalized tonic-clonic seizures (HP:0002069)3.86162857
13Gaze-evoked nystagmus (HP:0000640)3.84674685
14Dialeptic seizures (HP:0011146)3.79486854
15Ankle clonus (HP:0011448)3.58273409
16Supranuclear gaze palsy (HP:0000605)3.51950418
17Dysdiadochokinesis (HP:0002075)3.45025668
18Poor eye contact (HP:0000817)3.40715599
19Truncal ataxia (HP:0002078)3.36564262
20Impaired smooth pursuit (HP:0007772)3.30889928
21Depression (HP:0000716)3.29795364
22Broad-based gait (HP:0002136)3.25512884
23Dysmetria (HP:0001310)3.14875804
24Impaired social interactions (HP:0000735)3.12589806
25Abnormal social behavior (HP:0012433)3.12589806
26Impaired vibration sensation in the lower limbs (HP:0002166)3.11666591
27Abnormality of the lower motor neuron (HP:0002366)3.07320703
28Abnormal eating behavior (HP:0100738)3.07031026
29Scanning speech (HP:0002168)3.01317076
30Sleep apnea (HP:0010535)2.99607403
31Abnormality of ocular smooth pursuit (HP:0000617)2.93691435
32Postural instability (HP:0002172)2.92598424
33Urinary bladder sphincter dysfunction (HP:0002839)2.91254284
34Akinesia (HP:0002304)2.90954043
35Dysmetric saccades (HP:0000641)2.90742817
36Ventricular fibrillation (HP:0001663)2.90598644
37Anxiety (HP:0000739)2.89273637
38Genetic anticipation (HP:0003743)2.86707032
39Mutism (HP:0002300)2.82897119
40Pheochromocytoma (HP:0002666)2.78725581
41Hemiparesis (HP:0001269)2.73681818
42Hemiplegia (HP:0002301)2.71903769
43Spastic gait (HP:0002064)2.71199298
44Annular pancreas (HP:0001734)2.70683678
45Amblyopia (HP:0000646)2.66317811
46Intention tremor (HP:0002080)2.62926626
47Hyperventilation (HP:0002883)2.60917475
48Urinary urgency (HP:0000012)2.57537443
49Papilledema (HP:0001085)2.54194818
50Failure to thrive in infancy (HP:0001531)2.53856256
51Status epilepticus (HP:0002133)2.46580739
52Torticollis (HP:0000473)2.45536966
53Abnormality of binocular vision (HP:0011514)2.45193930
54Diplopia (HP:0000651)2.45193930
55Insidious onset (HP:0003587)2.44891418
56Termporal pattern (HP:0011008)2.44891418
57Bradykinesia (HP:0002067)2.41147981
58Epileptiform EEG discharges (HP:0011182)2.41055973
59Neuroendocrine neoplasm (HP:0100634)2.39896175
60Hyperinsulinemic hypoglycemia (HP:0000825)2.36221881
61EEG with generalized epileptiform discharges (HP:0011198)2.36177353
62Progressive inability to walk (HP:0002505)2.35150861
63Abnormality of the corticospinal tract (HP:0002492)2.33839108
64Stereotypic behavior (HP:0000733)2.28329701
65Apathy (HP:0000741)2.28327736
66Fetal akinesia sequence (HP:0001989)2.28025655
67Excessive salivation (HP:0003781)2.27866224
68Drooling (HP:0002307)2.27866224
69Focal dystonia (HP:0004373)2.25001387
70Abnormality of saccadic eye movements (HP:0000570)2.24945611
71Hypsarrhythmia (HP:0002521)2.21773732
72Bronchomalacia (HP:0002780)2.20226970
73Morphological abnormality of the pyramidal tract (HP:0002062)2.19346934
74Cerebral hypomyelination (HP:0006808)2.15763334
75Clonus (HP:0002169)2.14900280
76Impaired vibratory sensation (HP:0002495)2.13969546
77Lower limb muscle weakness (HP:0007340)2.13226028
78Tetraplegia (HP:0002445)2.12334824
79Pointed chin (HP:0000307)2.10563454
80Gait ataxia (HP:0002066)2.10265586
81Agitation (HP:0000713)2.09030487
82Polyphagia (HP:0002591)2.08412555
83Absent speech (HP:0001344)2.06585297
84Syncope (HP:0001279)2.05356590
85Neuronal loss in central nervous system (HP:0002529)2.04177881
86Hypoglycemic seizures (HP:0002173)2.03766625
87Rigidity (HP:0002063)2.02697318
88Diminished motivation (HP:0000745)2.01886648
89Limb dystonia (HP:0002451)2.01619104
90Insomnia (HP:0100785)1.99852332
91Ulnar claw (HP:0001178)1.99113401
92Macroorchidism (HP:0000053)1.99065657
93Craniofacial dystonia (HP:0012179)1.98776861
94Bundle branch block (HP:0011710)1.97983980
95Limb ataxia (HP:0002070)1.97824561
96Abnormal EKG (HP:0003115)1.94788426
97Neurofibrillary tangles (HP:0002185)1.94476976
98Rapidly progressive (HP:0003678)1.94387468
99Spastic tetraparesis (HP:0001285)1.94277501
100Impaired pain sensation (HP:0007328)1.92089804
101Abnormality of pain sensation (HP:0010832)1.92089804
102Incomplete penetrance (HP:0003829)1.91521732
103Postural tremor (HP:0002174)1.88823173
104Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.88210045
105Central scotoma (HP:0000603)1.87637414
106Psychosis (HP:0000709)1.86880656
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86771555
108Degeneration of the lateral corticospinal tracts (HP:0002314)1.86771555
109Hypoventilation (HP:0002791)1.86608806
110Megalencephaly (HP:0001355)1.84852764
111Diminished movement (HP:0002374)1.84791344
112Spinal canal stenosis (HP:0003416)1.84223102
113Generalized myoclonic seizures (HP:0002123)1.84133228
114Cerebral inclusion bodies (HP:0100314)1.83092998
115Inability to walk (HP:0002540)1.82636436
116Specific learning disability (HP:0001328)1.81654088
117Prolonged QT interval (HP:0001657)1.80373514
118Lower limb asymmetry (HP:0100559)1.78411130
119Hyperthyroidism (HP:0000836)1.77109711
120Neoplasm of the peripheral nervous system (HP:0100007)1.76685278
121Peripheral hypomyelination (HP:0007182)1.74565271
122Choreoathetosis (HP:0001266)1.74121914
123Increased circulating renin level (HP:0000848)1.70088035
124Paraplegia (HP:0010550)1.69581643
125Poor suck (HP:0002033)1.66818802

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.52853651
2MAP3K94.07749101
3EPHA43.21260389
4MAP3K42.99263454
5MINK12.99076802
6MARK12.61979580
7DAPK22.61188675
8PAK62.48555327
9MAP2K72.42001644
10KSR22.34912332
11MAP2K42.07953553
12PRKD32.02457931
13CAMKK12.01060219
14MAP3K121.98588489
15RIPK41.97832646
16NTRK11.96986270
17CAMKK21.96077344
18NTRK21.90766286
19KSR11.68403798
20ARAF1.60128990
21CASK1.59171747
22STK381.54371870
23DAPK11.52073601
24CDK51.51886340
25PRPF4B1.44916718
26TRIB31.38488072
27GRK51.34184828
28MAP2K61.33029662
29SIK31.31566987
30CDK191.29169327
31MAP3K21.26799706
32PRKCG1.24670773
33SGK2231.23391109
34SGK4941.23391109
35SIK11.22079137
36LMTK21.21013839
37SGK21.17795117
38TNIK1.17156855
39MAPK131.15048249
40MAP3K131.11039181
41CDK121.10710830
42PLK21.07612304
43CAMK1D1.07610847
44UHMK11.05331081
45SIK21.04444336
46PNCK1.02354434
47RET1.01868410
48SGK30.98543794
49PHKG20.97551673
50PHKG10.97551673
51WNK10.97387179
52TYRO30.96133930
53CAMK10.92488899
54CDK180.92342922
55RIPK10.89074756
56TAOK10.88668660
57CAMK2A0.88145175
58CDK140.86534708
59PRKCH0.86431007
60FES0.86117200
61CDK150.85735792
62INSRR0.84350741
63PINK10.84162396
64TAOK20.84011598
65MAP3K10.82827987
66LATS20.82650699
67STK110.79380813
68FGFR20.76658315
69ERBB20.75643534
70PTK2B0.74819539
71RAF10.73676556
72CDK11A0.73107043
73PDK10.72094198
74CDC42BPA0.71429375
75NEK10.70874075
76ALK0.70359506
77IRAK20.69201811
78MAPK150.68948109
79PAK30.67623679
80SGK10.67412959
81DYRK1A0.66787994
82TESK10.65602502
83CAMK2B0.62107039
84TNK20.61750499
85MARK20.61651774
86PDPK10.61210725
87OXSR10.59617564
88PKN20.59285385
89BCR0.56757021
90CAMK40.55314621
91CAMK1G0.54822779
92MAPK120.54504740
93PRKD20.54234191
94RPS6KA30.53184358
95CCNB10.52555852
96FER0.51786136
97EEF2K0.51279273
98BMPR20.51008229
99BRAF0.50684955
100PRKCI0.49042791
101MAP2K10.47861145
102ICK0.47859667
103CAMK2G0.47781680
104PRKAA10.47747361
105RPS6KA20.47720795
106SCYL20.46342002
107PRKCE0.46212060
108PRKCZ0.45157829
109BRD40.45084828
110CAMK2D0.44048872
111MAPK80.43292411
112MAPK100.43054156
113PKN10.42988771
114AKT30.42094048
115PTK20.39306916
116CSNK1G20.39169037
117FYN0.38716703
118PDK30.38014337
119PDK40.38014337
120BRSK10.35919217
121PRKCB0.35097215
122WNK30.34649671
123NEK60.34625270

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.81392774
2Synaptic vesicle cycle_Homo sapiens_hsa047213.60928249
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.65841122
4Olfactory transduction_Homo sapiens_hsa047402.64856813
5GABAergic synapse_Homo sapiens_hsa047272.64769151
6Circadian entrainment_Homo sapiens_hsa047132.64566308
7Long-term potentiation_Homo sapiens_hsa047202.62698509
8Glutamatergic synapse_Homo sapiens_hsa047242.53831947
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.48898629
10Morphine addiction_Homo sapiens_hsa050322.43349916
11Amphetamine addiction_Homo sapiens_hsa050312.32060904
12Insulin secretion_Homo sapiens_hsa049112.20325588
13Salivary secretion_Homo sapiens_hsa049702.16436980
14Dopaminergic synapse_Homo sapiens_hsa047282.09303129
15Taste transduction_Homo sapiens_hsa047421.96316170
16Cholinergic synapse_Homo sapiens_hsa047251.88179190
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.84720097
18Gastric acid secretion_Homo sapiens_hsa049711.78436497
19Long-term depression_Homo sapiens_hsa047301.73987695
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.69955981
21Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.64019173
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61842053
23Serotonergic synapse_Homo sapiens_hsa047261.61231610
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58122824
25Oxytocin signaling pathway_Homo sapiens_hsa049211.57957060
26Calcium signaling pathway_Homo sapiens_hsa040201.57433921
27Renin secretion_Homo sapiens_hsa049241.53777960
28Cocaine addiction_Homo sapiens_hsa050301.47741467
29Collecting duct acid secretion_Homo sapiens_hsa049661.47136467
30Type II diabetes mellitus_Homo sapiens_hsa049301.40955888
31GnRH signaling pathway_Homo sapiens_hsa049121.40272253
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.36873995
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.36285335
34Gap junction_Homo sapiens_hsa045401.29720563
35cAMP signaling pathway_Homo sapiens_hsa040241.24119827
36Estrogen signaling pathway_Homo sapiens_hsa049151.10582844
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02303020
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01210973
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.00244586
40Glioma_Homo sapiens_hsa052141.00026438
41Pancreatic secretion_Homo sapiens_hsa049720.98729572
42Cardiac muscle contraction_Homo sapiens_hsa042600.98350018
43Vibrio cholerae infection_Homo sapiens_hsa051100.94266305
44ErbB signaling pathway_Homo sapiens_hsa040120.94173873
45Dorso-ventral axis formation_Homo sapiens_hsa043200.91666531
46Melanogenesis_Homo sapiens_hsa049160.90819236
47Oocyte meiosis_Homo sapiens_hsa041140.90548734
48Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90343436
49Axon guidance_Homo sapiens_hsa043600.88620953
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.88594007
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.87071123
52Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86769890
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.85821755
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85452688
55Thyroid hormone synthesis_Homo sapiens_hsa049180.84525503
56Phototransduction_Homo sapiens_hsa047440.82877781
57Vitamin B6 metabolism_Homo sapiens_hsa007500.78955110
58Choline metabolism in cancer_Homo sapiens_hsa052310.73734281
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71788456
60Nitrogen metabolism_Homo sapiens_hsa009100.71777479
61MAPK signaling pathway_Homo sapiens_hsa040100.69388518
62Dilated cardiomyopathy_Homo sapiens_hsa054140.67332620
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67118599
64Neurotrophin signaling pathway_Homo sapiens_hsa047220.67104625
65Ovarian steroidogenesis_Homo sapiens_hsa049130.65020406
66Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64285170
67Inositol phosphate metabolism_Homo sapiens_hsa005620.63472362
68VEGF signaling pathway_Homo sapiens_hsa043700.62130727
69Glucagon signaling pathway_Homo sapiens_hsa049220.59435655
70Circadian rhythm_Homo sapiens_hsa047100.58331147
71mTOR signaling pathway_Homo sapiens_hsa041500.56857856
72Endocytosis_Homo sapiens_hsa041440.55851170
73Bile secretion_Homo sapiens_hsa049760.55223114
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53973897
75AMPK signaling pathway_Homo sapiens_hsa041520.51970135
76Fatty acid biosynthesis_Homo sapiens_hsa000610.51144016
77ABC transporters_Homo sapiens_hsa020100.50219364
78Rap1 signaling pathway_Homo sapiens_hsa040150.48072572
79Sphingolipid signaling pathway_Homo sapiens_hsa040710.47751460
80Ras signaling pathway_Homo sapiens_hsa040140.47127127
81Notch signaling pathway_Homo sapiens_hsa043300.46215012
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.45989982
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44391570
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43761993
85Insulin signaling pathway_Homo sapiens_hsa049100.42656497
86Alcoholism_Homo sapiens_hsa050340.41655299
87Endometrial cancer_Homo sapiens_hsa052130.41479388
88Type I diabetes mellitus_Homo sapiens_hsa049400.41048260
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.39582056
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.39055191
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38595373
92Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37499384
93Non-small cell lung cancer_Homo sapiens_hsa052230.37403215
94Tight junction_Homo sapiens_hsa045300.36740215
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35919523
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35733021
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33366920
98Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33116858
99Mineral absorption_Homo sapiens_hsa049780.32270966
100Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.32204345
101Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.31625896
102Arginine and proline metabolism_Homo sapiens_hsa003300.31587642
103Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.31267330
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31209610
105Prion diseases_Homo sapiens_hsa050200.31159099
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.30651112
107Histidine metabolism_Homo sapiens_hsa003400.30335194
108Wnt signaling pathway_Homo sapiens_hsa043100.29759248
109Renal cell carcinoma_Homo sapiens_hsa052110.26349126
110Prolactin signaling pathway_Homo sapiens_hsa049170.25695932
111Chemokine signaling pathway_Homo sapiens_hsa040620.24534433
112Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.23518690

Most similar genes based on co-expression Upload to Enrichr

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