TMEM55B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TMEM55B catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.47706663
2translational termination (GO:0006415)6.19807354
3central nervous system myelination (GO:0022010)6.04760280
4axon ensheathment in central nervous system (GO:0032291)6.04760280
5ribosomal small subunit biogenesis (GO:0042274)5.59230192
6cotranslational protein targeting to membrane (GO:0006613)5.40975285
7SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.36694360
8protein targeting to ER (GO:0045047)5.36423055
9establishment of protein localization to endoplasmic reticulum (GO:0072599)5.19985650
10translational elongation (GO:0006414)5.13174432
11protein localization to endoplasmic reticulum (GO:0070972)5.04539888
12cellular protein complex disassembly (GO:0043624)4.89212012
13ribosomal large subunit biogenesis (GO:0042273)4.84791204
14viral life cycle (GO:0019058)4.82525877
15translational initiation (GO:0006413)4.68926941
16positive thymic T cell selection (GO:0045059)4.66193117
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.60579924
18negative regulation of cell killing (GO:0031342)4.59663354
19negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.59663354
20immunoglobulin mediated immune response (GO:0016064)4.54600799
21response to muramyl dipeptide (GO:0032495)4.52353648
22antigen processing and presentation of endogenous antigen (GO:0019883)4.24992237
23B cell receptor signaling pathway (GO:0050853)4.21807296
24protein complex disassembly (GO:0043241)4.21583359
25positive regulation by symbiont of host defense response (GO:0052509)4.09141741
26modulation by symbiont of host defense response (GO:0052031)4.09141741
27modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.09141741
28modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.09141741
29positive regulation by organism of defense response of other organism involved in symbiotic interact4.09141741
30modulation by symbiont of host immune response (GO:0052553)4.09141741
31response to peptidoglycan (GO:0032494)4.06156962
32negative regulation of erythrocyte differentiation (GO:0045647)4.04896462
33macromolecular complex disassembly (GO:0032984)4.04117325
34antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.98507956
35positive regulation of gamma-delta T cell activation (GO:0046645)3.85572148
36detection of bacterium (GO:0016045)3.80870806
37detection of other organism (GO:0098543)3.77263512
38maturation of SSU-rRNA (GO:0030490)3.75428848
39protein targeting to membrane (GO:0006612)3.75301486
40neuronal action potential propagation (GO:0019227)3.69023473
41antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.68081885
42regulation of interferon-beta biosynthetic process (GO:0045357)3.62968277
43detection of temperature stimulus involved in sensory perception (GO:0050961)3.58529139
44detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.58529139
45thymic T cell selection (GO:0045061)3.56313120
46ribosomal small subunit assembly (GO:0000028)3.55568677
47antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.55297257
48DNA deamination (GO:0045006)3.54628943
49positive T cell selection (GO:0043368)3.54176160
50regulation of B cell receptor signaling pathway (GO:0050855)3.53742019
51ncRNA 3-end processing (GO:0043628)3.49856534
52nuclear envelope reassembly (GO:0031468)3.49801279
53mitotic nuclear envelope reassembly (GO:0007084)3.49801279
54establishment of mitochondrion localization (GO:0051654)3.48063381
55leukocyte aggregation (GO:0070486)3.41364411
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.41218908
57axon ensheathment (GO:0008366)3.39555576
58ensheathment of neurons (GO:0007272)3.39555576
59negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.39316282
60translation (GO:0006412)3.38529619
61negative regulation of granulocyte differentiation (GO:0030853)3.34836975
62myelination (GO:0042552)3.34435836
63positive regulation of protein homooligomerization (GO:0032464)3.34223721
64macrophage activation involved in immune response (GO:0002281)3.33811628
65regulation of mast cell degranulation (GO:0043304)3.32221497
66regulation of T-helper 2 cell differentiation (GO:0045628)3.30803558
67negative regulation of microtubule polymerization (GO:0031115)3.29428507
68positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.25925148
69chaperone mediated protein folding requiring cofactor (GO:0051085)3.22484046
70embryonic process involved in female pregnancy (GO:0060136)3.18387192
71chaperone-mediated protein transport (GO:0072321)3.15834119
72T cell selection (GO:0045058)3.15496351
73protein maturation by protein folding (GO:0022417)3.14769143
74nuclear-transcribed mRNA catabolic process (GO:0000956)3.14760936
75defense response to protozoan (GO:0042832)3.13328934
76B cell mediated immunity (GO:0019724)3.13184777
77NIK/NF-kappaB signaling (GO:0038061)3.13000620
78peptidyl-cysteine modification (GO:0018198)3.12755292
79L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.12048450
80synaptic vesicle maturation (GO:0016188)3.12005432
81termination of RNA polymerase III transcription (GO:0006386)3.11383347
82transcription elongation from RNA polymerase III promoter (GO:0006385)3.11383347
83regulation of leukocyte degranulation (GO:0043300)3.09592871
84positive regulation of oligodendrocyte differentiation (GO:0048714)3.09196724
85interferon-gamma-mediated signaling pathway (GO:0060333)3.07041254
86fatty acid elongation (GO:0030497)3.05167098
87ribonucleoprotein complex biogenesis (GO:0022613)3.04758934
88respiratory burst (GO:0045730)3.04416437
89B cell homeostasis (GO:0001782)3.02916296
90detection of temperature stimulus (GO:0016048)3.02836099
91negative regulation of toll-like receptor signaling pathway (GO:0034122)3.02247329
92neutrophil activation involved in immune response (GO:0002283)3.01980059
93positive regulation of Rap GTPase activity (GO:0032854)3.00539215
94negative regulation of interleukin-12 production (GO:0032695)2.97605170
95mRNA catabolic process (GO:0006402)2.97512937
96regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.96303973
97response to protozoan (GO:0001562)2.95992963
98CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.92252133
99regulation of myeloid leukocyte mediated immunity (GO:0002886)2.91406908
100regulation of antigen processing and presentation (GO:0002577)2.90078990
101cellular response to virus (GO:0098586)2.88819169
102positive regulation of type 2 immune response (GO:0002830)2.88171039
103regulation of dendritic cell antigen processing and presentation (GO:0002604)2.86998199
104long-chain fatty acid biosynthetic process (GO:0042759)2.86848028
105protein targeting (GO:0006605)2.86054927
106regulation of NFAT protein import into nucleus (GO:0051532)2.85799121
107modulation by virus of host process (GO:0019054)2.85662377
108detection of external biotic stimulus (GO:0098581)2.85618994
109establishment of protein localization to membrane (GO:0090150)2.85447601
110negative thymic T cell selection (GO:0045060)2.85258589
111positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.84250253
112regulation of mast cell activation involved in immune response (GO:0033006)2.83975825
113negative regulation of calcium ion transport into cytosol (GO:0010523)2.79878975
114RNA catabolic process (GO:0006401)2.78103749
115positive regulation of B cell differentiation (GO:0045579)2.77756834
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.76910414
117mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.76796525
118regulation of regulated secretory pathway (GO:1903305)2.76561448
119mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.75654062
120germinal center formation (GO:0002467)2.74647028
121tolerance induction (GO:0002507)2.73835496
122regulation of necroptotic process (GO:0060544)2.73657376
123proteasome assembly (GO:0043248)2.73171469
124positive regulation of mast cell activation (GO:0033005)2.72272113
125negative regulation of lymphocyte mediated immunity (GO:0002707)2.69480000
126regulation of early endosome to late endosome transport (GO:2000641)2.69345971
127mannose metabolic process (GO:0006013)2.68450057
128protein palmitoylation (GO:0018345)2.67907914
129cellular response to type I interferon (GO:0071357)2.67297815
130type I interferon signaling pathway (GO:0060337)2.67297815
131regulation of ARF protein signal transduction (GO:0032012)2.65990903
132modulation by symbiont of host cellular process (GO:0044068)2.65450313
133response to type I interferon (GO:0034340)2.64652672
134negative T cell selection (GO:0043383)2.63559900
135lipopolysaccharide-mediated signaling pathway (GO:0031663)2.62620417
136regulation of gamma-delta T cell activation (GO:0046643)2.62297798
137rRNA processing (GO:0006364)2.60875317
138pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.60494561
139establishment of protein localization to organelle (GO:0072594)2.60414599
140energy coupled proton transport, down electrochemical gradient (GO:0015985)2.60156845
141ATP synthesis coupled proton transport (GO:0015986)2.60156845
142positive regulation of mast cell activation involved in immune response (GO:0033008)2.59240889
143positive regulation of mast cell degranulation (GO:0043306)2.59240889
144negative regulation of type I interferon production (GO:0032480)2.58923092
145positive regulation of cellular amide metabolic process (GO:0034250)2.58849467
146negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.57677533
147regulation of monocyte differentiation (GO:0045655)2.57618793
148DNA strand elongation involved in DNA replication (GO:0006271)2.57048695
149regulation of B cell differentiation (GO:0045577)2.56731508
150regulation of necrotic cell death (GO:0010939)2.56348936
151negative regulation of leukocyte mediated immunity (GO:0002704)2.55952989
152establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.55909373
153mitochondrion transport along microtubule (GO:0047497)2.55909373
154amino acid import (GO:0043090)2.55374805
155antigen receptor-mediated signaling pathway (GO:0050851)2.54701523
156response to host immune response (GO:0052572)2.54313024
157response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.54313024
158regulation of type 2 immune response (GO:0002828)2.54082609
159positive regulation of interferon-alpha production (GO:0032727)2.53951007
160cellular protein complex localization (GO:0034629)2.53175271
161protein neddylation (GO:0045116)2.53081825
162pseudouridine synthesis (GO:0001522)2.53005760
163L-serine transport (GO:0015825)2.52603879
164cellular component biogenesis (GO:0044085)2.52341864
165positive regulation of B cell proliferation (GO:0030890)2.52142900
166myeloid dendritic cell differentiation (GO:0043011)2.52066412
167establishment of viral latency (GO:0019043)2.51854856
168negative regulation of innate immune response (GO:0045824)2.51621526
169telomere maintenance via semi-conservative replication (GO:0032201)2.50868826
170activation of MAPKKK activity (GO:0000185)2.50538776
171regulation of defense response to virus by virus (GO:0050690)2.49749389
172mature B cell differentiation (GO:0002335)2.49623483
173activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.47929864
174rRNA metabolic process (GO:0016072)2.47377679
175synaptic vesicle exocytosis (GO:0016079)2.45446719
176negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.44416604
177GTP biosynthetic process (GO:0006183)2.44060603
178establishment of protein localization to mitochondrion (GO:0072655)2.43263131
179protein targeting to mitochondrion (GO:0006626)2.42030278
180substantia nigra development (GO:0021762)2.41003741
181establishment of integrated proviral latency (GO:0075713)2.39874501
182cell migration in hindbrain (GO:0021535)2.38798484
183serine transport (GO:0032329)2.37990415
184establishment of protein localization to mitochondrial membrane (GO:0090151)2.37803196
185DNA strand elongation (GO:0022616)2.37384554
186protein localization to membrane (GO:0072657)2.36908778
187negative regulation of GTP catabolic process (GO:0033125)2.36863799
188negative regulation of GTPase activity (GO:0034260)2.36863799
189regulation of protein heterodimerization activity (GO:0043497)2.36088343
190spliceosomal snRNP assembly (GO:0000387)2.35566690
191cholesterol biosynthetic process (GO:0006695)2.33387850
192UTP biosynthetic process (GO:0006228)2.33218318
193neuromuscular process controlling posture (GO:0050884)2.31747726
194pteridine-containing compound biosynthetic process (GO:0042559)2.30648873
195GDP-mannose metabolic process (GO:0019673)2.28363369
196negative regulation of execution phase of apoptosis (GO:1900118)2.28166818
197adult walking behavior (GO:0007628)2.27815430
198negative regulation of neurotransmitter transport (GO:0051589)2.26760792
199peptidyl-arginine omega-N-methylation (GO:0035247)2.26295199

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.04608826
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.74569555
3MYC_19079543_ChIP-ChIP_MESCs_Mouse3.32407411
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.32225777
5ETS1_20019798_ChIP-Seq_JURKAT_Human3.08075941
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.95856067
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.79495069
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.78873677
9* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.77823585
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.74755964
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.72743802
12* XRN2_22483619_ChIP-Seq_HELA_Human2.71465885
13KDM2B_26808549_Chip-Seq_SUP-B15_Human2.66257583
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.63084723
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60611907
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.58847978
17KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.54875213
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.46952743
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.38708972
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.38339420
21TCF7_22412390_ChIP-Seq_EML_Mouse2.35763172
22KDM2B_26808549_Chip-Seq_DND41_Human2.35390050
23* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33495769
24* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32803993
25KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.24781914
26KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.24781914
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.24781914
28THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22497145
29DCP1A_22483619_ChIP-Seq_HELA_Human2.19348087
30E2F7_22180533_ChIP-Seq_HELA_Human2.15329398
31* VDR_21846776_ChIP-Seq_THP-1_Human2.13477514
32MAF_26560356_Chip-Seq_TH1_Human2.12973502
33ELK3_25401928_ChIP-Seq_HUVEC_Human2.12591266
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.12286484
35SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.07793035
36TTF2_22483619_ChIP-Seq_HELA_Human1.99774296
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94832840
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.92522493
39VDR_23849224_ChIP-Seq_CD4+_Human1.92467242
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.92399931
41* UTX_26944678_Chip-Seq_JUKART_Human1.91881925
42* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.91822815
43RUNX1_22412390_ChIP-Seq_EML_Mouse1.89629687
44* TFEB_21752829_ChIP-Seq_HELA_Human1.88862697
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.84955045
46NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81984387
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78742421
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76127592
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75700667
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.74428079
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71957165
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.71064497
53IRF8_21731497_ChIP-ChIP_J774_Mouse1.70685939
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.69909420
55BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69412283
56KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66715444
57RACK7_27058665_Chip-Seq_MCF-7_Human1.66557699
58SRY_22984422_ChIP-ChIP_TESTIS_Rat1.66030938
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.65249405
60SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.64292940
61GABP_19822575_ChIP-Seq_HepG2_Human1.64119172
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.62810211
63KDM2B_26808549_Chip-Seq_K562_Human1.62465098
64* IRF8_27001747_Chip-Seq_BMDM_Mouse1.60987476
65STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.59439924
66* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.58455187
67P68_20966046_ChIP-Seq_HELA_Human1.57786525
68CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.57669336
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.55560080
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55020234
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54596211
72MYB_21317192_ChIP-Seq_ERMYB_Mouse1.54073617
73FOXP3_21729870_ChIP-Seq_TREG_Human1.54035002
74STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53172600
75TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.53147577
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.53142520
77* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51374708
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51205754
79KDM2B_26808549_Chip-Seq_JURKAT_Human1.50612432
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48730820
81PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48072369
82ELF1_20517297_ChIP-Seq_JURKAT_Human1.47861329
83SCL_19346495_ChIP-Seq_HPC-7_Human1.46671336
84NELFA_20434984_ChIP-Seq_ESCs_Mouse1.42383206
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.41864686
86TET1_21451524_ChIP-Seq_MESCs_Mouse1.40724765
87ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39570418
88* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39211674
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37928583
90EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37754277
91GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36918907
92BCOR_27268052_Chip-Seq_Bcells_Human1.36724244
93ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36496136
94BCL6_27268052_Chip-Seq_Bcells_Human1.36318071
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.35435400
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34132733
97FOXP1_21924763_ChIP-Seq_HESCs_Human1.32926990
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.32880067
99EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32829548
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32527181
101FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31307839
102YY1_22570637_ChIP-Seq_MALME-3M_Human1.31098279
103* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30804892
104SMC4_20622854_ChIP-Seq_HELA_Human1.30736571
105CTCF_18555785_ChIP-Seq_MESCs_Mouse1.30284828
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.29471867
107KDM5A_27292631_Chip-Seq_BREAST_Human1.29470365
108E2F4_17652178_ChIP-ChIP_JURKAT_Human1.29228887
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.28221482
110CREB1_26743006_Chip-Seq_LNCaP_Human1.28056885
111SPI1_23127762_ChIP-Seq_K562_Human1.27849064
112MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26842828
113SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26700350
114FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26446921
115RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.26316071
116* VDR_24763502_ChIP-Seq_THP-1_Human1.25203316
117MYB_26560356_Chip-Seq_TH2_Human1.24469897
118NANOG_18555785_ChIP-Seq_MESCs_Mouse1.24286411
119* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.23963086
120MYB_26560356_Chip-Seq_TH1_Human1.23272819
121ELK1_22589737_ChIP-Seq_MCF10A_Human1.21767261
122DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20605476
123NCOR1_26117541_ChIP-Seq_K562_Human1.19927551
124* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19904739
125* CIITA_25753668_ChIP-Seq_RAJI_Human1.18915779
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18793120
127RUNX_20019798_ChIP-Seq_JUKART_Human1.18430968
128RARG_19884340_ChIP-ChIP_MEFs_Mouse1.18230755
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18192917
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.17415910
131OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16992124
132* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16884007
133* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.16579276
134* SPI1_23547873_ChIP-Seq_NB4_Human1.16497395
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16381288
136TCF3_18692474_ChIP-Seq_MEFs_Mouse1.15952346
137SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14976276
138SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14512950
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.14346306
140SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.13136264
141PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11797441
142MYC_22102868_ChIP-Seq_BL_Human1.11649004
143GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11566473
144LXR_22292898_ChIP-Seq_THP-1_Human1.10652736
145ERG_21242973_ChIP-ChIP_JURKAT_Human1.10622893
146TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.09000035
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06597724
148ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06439697
149* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.05740266
150CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05725890
151SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05612817
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05358389
153MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.05278219
154CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04510424
155* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04228932
156CTCF_26484167_Chip-Seq_Bcells_Mouse1.03814612
157* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03402282
158ZNF263_19887448_ChIP-Seq_K562_Human1.03352349
159SA1_27219007_Chip-Seq_ERYTHROID_Human1.02481391
160* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01741640
161GATA1_19941826_ChIP-Seq_K562_Human1.01712152
162POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.00855248
163SA1_27219007_Chip-Seq_Bcells_Human0.95949052
164BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95509635
165NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.93544635
166IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93194593
167ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93018539
168MAF_26560356_Chip-Seq_TH2_Human0.92539249
169NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.91116174
170GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90744797
171* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.90368937
172EOMES_21245162_ChIP-Seq_HESCs_Human0.90282355
173PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89949166
174STAT1_20625510_ChIP-Seq_HELA_Human0.89298973
175RARB_27405468_Chip-Seq_BRAIN_Mouse0.88789930
176FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87670415
177DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87551089

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to4.17148962
2MP0009379_abnormal_foot_pigmentation3.88988513
3MP0003880_abnormal_central_pattern3.41068872
4MP0005058_abnormal_lysosome_morphology3.01022988
5MP0000920_abnormal_myelination2.91681340
6MP0001790_abnormal_immune_system2.89788724
7MP0005387_immune_system_phenotype2.89788724
8MP0001835_abnormal_antigen_presentation2.76787447
9MP0005671_abnormal_response_to2.58648064
10MP0004270_analgesia2.55172143
11MP0003724_increased_susceptibility_to2.50571046
12MP0002419_abnormal_innate_immunity2.46022425
13MP0003183_abnormal_peptide_metabolism2.39396057
14MP0005451_abnormal_body_composition2.39386757
15MP0005025_abnormal_response_to2.36377616
16MP0004947_skin_inflammation2.35516170
17MP0002420_abnormal_adaptive_immunity2.34488554
18MP0001819_abnormal_immune_cell2.32386199
19MP0004142_abnormal_muscle_tone2.26273609
20MP0009278_abnormal_bone_marrow2.20878473
21MP0004859_abnormal_synaptic_plasticity2.20400540
22MP0002148_abnormal_hypersensitivity_rea2.17907330
23MP0001529_abnormal_vocalization2.10477080
24MP0003191_abnormal_cellular_cholesterol2.09903850
25MP0003329_amyloid_beta_deposits2.06535669
26MP0005464_abnormal_platelet_physiology2.06483883
27MP0003303_peritoneal_inflammation2.05197929
28MP0003763_abnormal_thymus_physiology2.03920450
29MP0003172_abnormal_lysosome_physiology2.01847007
30MP0002064_seizures2.01062316
31MP0002733_abnormal_thermal_nociception2.00701816
32MP0002398_abnormal_bone_marrow1.96114801
33MP0003136_yellow_coat_color1.90108400
34MP0005174_abnormal_tail_pigmentation1.86922977
35MP0000716_abnormal_immune_system1.85344789
36MP0001986_abnormal_taste_sensitivity1.84547485
37MP0002734_abnormal_mechanical_nocicepti1.78976157
38MP0003300_gastrointestinal_ulcer1.78897936
39MP0008932_abnormal_embryonic_tissue1.77652493
40MP0005423_abnormal_somatic_nervous1.77402739
41MP0004510_myositis1.76161717
42MP0009785_altered_susceptibility_to1.75801142
43MP0001970_abnormal_pain_threshold1.75016244
44MP0002405_respiratory_system_inflammati1.73367144
45MP0001968_abnormal_touch/_nociception1.72931279
46MP0001533_abnormal_skeleton_physiology1.71310527
47MP0000462_abnormal_digestive_system1.69326187
48MP0002272_abnormal_nervous_system1.68320757
49MP0003634_abnormal_glial_cell1.67705477
50MP0000689_abnormal_spleen_morphology1.67546572
51MP0009046_muscle_twitch1.64850113
52MP0003635_abnormal_synaptic_transmissio1.63351964
53MP0004885_abnormal_endolymph1.62565878
54MP0004957_abnormal_blastocyst_morpholog1.61448786
55MP0005379_endocrine/exocrine_gland_phen1.61060613
56MP0010155_abnormal_intestine_physiology1.58687001
57MP0002229_neurodegeneration1.56554963
58MP0002722_abnormal_immune_system1.54702790
59MP0001905_abnormal_dopamine_level1.54346599
60MP0000955_abnormal_spinal_cord1.54104332
61MP0001545_abnormal_hematopoietic_system1.53158873
62MP0005397_hematopoietic_system_phenotyp1.53158873
63MP0000778_abnormal_nervous_system1.52673449
64MP0008260_abnormal_autophagy1.52360213
65MP0002429_abnormal_blood_cell1.50795463
66MP0001853_heart_inflammation1.49011996
67MP0002163_abnormal_gland_morphology1.48076846
68MP0004133_heterotaxia1.47501820
69MP0006276_abnormal_autonomic_nervous1.45755859
70MP0003690_abnormal_glial_cell1.43599744
71MP0000604_amyloidosis1.43002408
72MP0001348_abnormal_lacrimal_gland1.41206918
73MP0002653_abnormal_ependyma_morphology1.39077671
74MP0001485_abnormal_pinna_reflex1.37429236
75MP0005310_abnormal_salivary_gland1.37031857
76MP0002735_abnormal_chemical_nociception1.36976048
77MP0001486_abnormal_startle_reflex1.36553119
78MP0001845_abnormal_inflammatory_respons1.36515522
79MP0002736_abnormal_nociception_after1.33887944
80MP0003693_abnormal_embryo_hatching1.31768959
81MP0008057_abnormal_DNA_replication1.30217495
82MP0000703_abnormal_thymus_morphology1.29050934
83MP0003075_altered_response_to1.28844358
84MP0000858_altered_metastatic_potential1.27665173
85MP0005075_abnormal_melanosome_morpholog1.27167679
86MP0002751_abnormal_autonomic_nervous1.21626606
87MP0002882_abnormal_neuron_morphology1.19650002
88MP0008469_abnormal_protein_level1.19643315
89MP0004185_abnormal_adipocyte_glucose1.19566502
90MP0002909_abnormal_adrenal_gland1.19031679
91MP0009745_abnormal_behavioral_response1.18456698
92MP0003453_abnormal_keratinocyte_physiol1.17969349
93MP0002998_abnormal_bone_remodeling1.17732533
94MP0004742_abnormal_vestibular_system1.16612114
95MP0002067_abnormal_sensory_capabilities1.16527524
96MP0006072_abnormal_retinal_apoptosis1.16501469
97MP0003938_abnormal_ear_development1.13441153
98MP0002572_abnormal_emotion/affect_behav1.13424095
99MP0003283_abnormal_digestive_organ1.13353847
100MP0002138_abnormal_hepatobiliary_system1.12666575
101MP0002066_abnormal_motor_capabilities/c1.11851994
102MP0005409_darkened_coat_color1.10699823
103MP0003656_abnormal_erythrocyte_physiolo1.07725886
104MP0002638_abnormal_pupillary_reflex1.05901415
105MP0000015_abnormal_ear_pigmentation1.05721236
106MP0008569_lethality_at_weaning1.05268258
107MP0003828_pulmonary_edema1.04781924
108MP0003632_abnormal_nervous_system1.02849724
109MP0003879_abnormal_hair_cell1.01523500
110MP0002184_abnormal_innervation0.99622258
111MP0004811_abnormal_neuron_physiology0.99415722
112MP0000613_abnormal_salivary_gland0.98987336
113MP0005076_abnormal_cell_differentiation0.98963730
114MP0000343_altered_response_to0.96924276
115MP0009764_decreased_sensitivity_to0.94920788
116MP0001440_abnormal_grooming_behavior0.94324116
117MP0001873_stomach_inflammation0.92550848
118MP0003866_abnormal_defecation0.92105439
119MP0005000_abnormal_immune_tolerance0.91572259
120MP0002752_abnormal_somatic_nervous0.91547921
121MP0002152_abnormal_brain_morphology0.90776398
122MP0008874_decreased_physiological_sensi0.88447845
123MP0002063_abnormal_learning/memory/cond0.88358788
124MP0005166_decreased_susceptibility_to0.87858017
125MP0009840_abnormal_foam_cell0.86926100
126MP0003091_abnormal_cell_migration0.86598366
127MP0003705_abnormal_hypodermis_morpholog0.85741651
128MP0006082_CNS_inflammation0.85657183
129MP0001851_eye_inflammation0.83792972
130MP0002009_preneoplasia0.83779482
131MP0001800_abnormal_humoral_immune0.83762665
132MP0004381_abnormal_hair_follicle0.83430628
133MP0001663_abnormal_digestive_system0.81945728
134MP0004858_abnormal_nervous_system0.81834684
135MP0000490_abnormal_crypts_of0.80044825
136MP0003787_abnormal_imprinting0.79995722
137MP0003631_nervous_system_phenotype0.79785362
138MP0001849_ear_inflammation0.79243866
139MP0003633_abnormal_nervous_system0.78157567
140MP0009333_abnormal_splenocyte_physiolog0.78028532
141MP0002277_abnormal_respiratory_mucosa0.77047972
142MP0004808_abnormal_hematopoietic_stem0.75937506
143MP0001188_hyperpigmentation0.75664315
144MP0002139_abnormal_hepatobiliary_system0.75077699
145MP0003077_abnormal_cell_cycle0.74393123
146MP0002723_abnormal_immune_serum0.72986547
147MP0000358_abnormal_cell_content/0.71810154
148MP0005666_abnormal_adipose_tissue0.70843381
149MP0002557_abnormal_social/conspecific_i0.70635766
150MP0005390_skeleton_phenotype0.70258763
151MP0002796_impaired_skin_barrier0.70029967
152MP0002452_abnormal_antigen_presenting0.69824511
153MP0000685_abnormal_immune_system0.68517936
154MP0003011_delayed_dark_adaptation0.67263791
155MP0003111_abnormal_nucleus_morphology0.66370174
156MP0003123_paternal_imprinting0.64992235
157MP0000350_abnormal_cell_proliferation0.64812936
158MP0003861_abnormal_nervous_system0.64465870
159MP0006292_abnormal_olfactory_placode0.63738079
160MP0005381_digestive/alimentary_phenotyp0.62155007
161MP0000249_abnormal_blood_vessel0.61419478
162MP0001730_embryonic_growth_arrest0.61396184
163MP0005535_abnormal_body_temperature0.60236619
164MP0000465_gastrointestinal_hemorrhage0.59895216
165MP0002693_abnormal_pancreas_physiology0.59299032
166MP0005501_abnormal_skin_physiology0.59253633
167MP0002089_abnormal_postnatal_growth/wei0.58535565
168MP0002933_joint_inflammation0.57891724
169MP0005621_abnormal_cell_physiology0.55388289
170MP0009115_abnormal_fat_cell0.53042039
171MP0009763_increased_sensitivity_to0.52316760

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.21121962
2Agammaglobulinemia (HP:0004432)4.51269406
3Abnormality of macrophages (HP:0004311)4.23374402
4Cellulitis (HP:0100658)4.16239688
5Recurrent bacterial skin infections (HP:0005406)4.11592693
6Mediastinal lymphadenopathy (HP:0100721)4.09044443
7Cerebral hypomyelination (HP:0006808)4.00142486
8Abnormality of liposaccharide metabolism (HP:0010968)3.94778062
9Abnormality of glycosphingolipid metabolism (HP:0004343)3.94778062
10Abnormality of glycolipid metabolism (HP:0010969)3.94778062
11Recurrent abscess formation (HP:0002722)3.94375095
12Neurofibrillary tangles (HP:0002185)3.83996534
13Supranuclear gaze palsy (HP:0000605)3.81195552
14Meningitis (HP:0001287)3.74008498
15Chronic obstructive pulmonary disease (HP:0006510)3.68004530
16Obstructive lung disease (HP:0006536)3.68004530
17Abnormality of cells of the erythroid lineage (HP:0012130)3.63301004
18Recurrent fungal infections (HP:0002841)3.48786239
19Reticulocytopenia (HP:0001896)3.45450128
20Recurrent gram-negative bacterial infections (HP:0005420)3.43718951
21Macrocytic anemia (HP:0001972)3.37286605
22Gastrointestinal stroma tumor (HP:0100723)3.36312590
23Abnormal delayed hypersensitivity skin test (HP:0002963)3.32792774
24Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.32771275
25Abnormal number of erythroid precursors (HP:0012131)3.26942131
26Gastrointestinal inflammation (HP:0004386)3.21477549
27Elevated circulating parathyroid hormone (PTH) level (HP:0003165)3.20811475
28Abnormal hemoglobin (HP:0011902)3.20801697
29Increased IgE level (HP:0003212)3.17235129
30Colitis (HP:0002583)3.12498295
31Parakeratosis (HP:0001036)3.08858912
32Pallor (HP:0000980)3.07114045
33Mutism (HP:0002300)3.06667754
34Inflammation of the large intestine (HP:0002037)3.05666505
35Increased cerebral lipofuscin (HP:0011813)3.04081708
36Vasculitis (HP:0002633)2.98723467
37Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.97500184
38Degeneration of the lateral corticospinal tracts (HP:0002314)2.97500184
39Peripheral hypomyelination (HP:0007182)2.94849088
40Concave nail (HP:0001598)2.91689952
41Aplasia/Hypoplasia of the sacrum (HP:0008517)2.90127294
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.89770965
43Dysostosis multiplex (HP:0000943)2.89269420
44Neuronal loss in central nervous system (HP:0002529)2.85376082
45Retinal dysplasia (HP:0007973)2.84505682
46Verrucae (HP:0200043)2.84280971
47Papilloma (HP:0012740)2.84280971
48Myositis (HP:0100614)2.81665107
49Cerebral inclusion bodies (HP:0100314)2.81472060
50Recurrent skin infections (HP:0001581)2.81061309
51Obstructive sleep apnea (HP:0002870)2.79892758
52Chronic mucocutaneous candidiasis (HP:0002728)2.72950110
53Recurrent cutaneous fungal infections (HP:0011370)2.72950110
54Urticaria (HP:0001025)2.71393874
55Recurrent viral infections (HP:0004429)2.69002477
56Hypercortisolism (HP:0001578)2.64879538
57Hemorrhage of the eye (HP:0011885)2.61238520
58Elevated erythrocyte sedimentation rate (HP:0003565)2.60573556
59Panhypogammaglobulinemia (HP:0003139)2.59852781
60Orchitis (HP:0100796)2.59077639
61Purpura (HP:0000979)2.58087950
62Type II lissencephaly (HP:0007260)2.53893452
63Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.52828277
64Spontaneous hematomas (HP:0007420)2.45369406
65Polygenic inheritance (HP:0010982)2.44002294
66Increased hepatocellular lipid droplets (HP:0006565)2.43835899
67Abnormality of the corticospinal tract (HP:0002492)2.42891702
68Osteomyelitis (HP:0002754)2.42841721
69Split foot (HP:0001839)2.41462681
70Lymphopenia (HP:0001888)2.40966145
71Restrictive lung disease (HP:0002091)2.39944007
72Encephalitis (HP:0002383)2.39710922
73Increased IgM level (HP:0003496)2.38965215
74Progressive neurologic deterioration (HP:0002344)2.38751064
75Optic neuritis (HP:0100653)2.37665000
76Retrobulbar optic neuritis (HP:0100654)2.37665000
77Visual hallucinations (HP:0002367)2.36876221
78CNS hypomyelination (HP:0003429)2.36858678
79Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36673660
80Asplenia (HP:0001746)2.32221101
81Recurrent sinusitis (HP:0011108)2.31068362
82Recurrent bronchitis (HP:0002837)2.31068234
83Pustule (HP:0200039)2.30979240
84Exertional dyspnea (HP:0002875)2.28850486
85Segmental peripheral demyelination/remyelination (HP:0003481)2.28567723
86Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27923211
87Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27923211
88Abnormality of cells of the lymphoid lineage (HP:0012140)2.27784213
89Myokymia (HP:0002411)2.27109106
90Prolonged bleeding time (HP:0003010)2.26591303
91Recurrent pneumonia (HP:0006532)2.26390133
92Systemic lupus erythematosus (HP:0002725)2.25266304
93Hypochromic anemia (HP:0001931)2.24733851
94Gastrointestinal infarctions (HP:0005244)2.23363947
95Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.23142305
96Emphysema (HP:0002097)2.22490395
97Recurrent lower respiratory tract infections (HP:0002783)2.21986341
98Gingivitis (HP:0000230)2.21703643
99Deep palmar crease (HP:0006191)2.21296285
100Hyperphosphatemia (HP:0002905)2.20302613
101Thoracic kyphosis (HP:0002942)2.19569202
102Sepsis (HP:0100806)2.19316618
103Increased intramyocellular lipid droplets (HP:0012240)2.18703330
104Epistaxis (HP:0000421)2.18083459
105Pulmonary infiltrates (HP:0002113)2.15789345
106Sensory axonal neuropathy (HP:0003390)2.14493671
107Clumsiness (HP:0002312)2.12428728
108Stenosis of the external auditory canal (HP:0000402)2.11844423
109Petechiae (HP:0000967)2.11780195
110Spastic gait (HP:0002064)2.09519746
111Achilles tendon contracture (HP:0001771)2.08965637
112Alacrima (HP:0000522)2.07490990
113Hypertensive crisis (HP:0100735)2.07067458
114Postnatal microcephaly (HP:0005484)2.06603949
115Renal Fanconi syndrome (HP:0001994)2.05215185
116Growth hormone excess (HP:0000845)2.04586820
117Abnormal large intestine physiology (HP:0012700)2.04456973
118Increased serum ferritin (HP:0003281)2.02834790
119Flat occiput (HP:0005469)2.02671118
120Broad face (HP:0000283)2.01596455
121Aplasia/Hypoplasia of the spleen (HP:0010451)2.00478970
122Bowel incontinence (HP:0002607)1.98484945
123Diminished motivation (HP:0000745)1.96150640
124Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.94364322
125Mitochondrial inheritance (HP:0001427)1.93483913
126Emotional lability (HP:0000712)1.93398071
127Slow saccadic eye movements (HP:0000514)1.93017588
128Lipid accumulation in hepatocytes (HP:0006561)1.91514046
129Ankle clonus (HP:0011448)1.91507081
130Abnormality of the thoracic spine (HP:0100711)1.90102131
131Cerebellar dysplasia (HP:0007033)1.89591481
132Hemoptysis (HP:0002105)1.88675799
133Loss of speech (HP:0002371)1.88414297
134Skin rash (HP:0000988)1.86414890
135Delusions (HP:0000746)1.86014985
136Restlessness (HP:0000711)1.85906800
137Abnormal autonomic nervous system physiology (HP:0012332)1.85630003
138Apathy (HP:0000741)1.85245190
139Dysautonomia (HP:0002459)1.85096559
140Orthostatic hypotension (HP:0001278)1.85049932
141Hepatocellular necrosis (HP:0001404)1.84708196
142Partial duplication of thumb phalanx (HP:0009944)1.82563859
143Long palpebral fissure (HP:0000637)1.82061085
144Gingival bleeding (HP:0000225)1.82032501
145Viral hepatitis (HP:0006562)1.81014367
146Absent radius (HP:0003974)1.80201263
147Rough bone trabeculation (HP:0100670)1.80053941
148External ophthalmoplegia (HP:0000544)1.80001221
149Dysmetria (HP:0001310)1.79621367
150Progressive inability to walk (HP:0002505)1.78756489
151Skin ulcer (HP:0200042)1.78441004
152Spastic paraparesis (HP:0002313)1.78339146
153Hepatosplenomegaly (HP:0001433)1.78012640
154Anteriorly placed anus (HP:0001545)1.77817318
155Vacuolated lymphocytes (HP:0001922)1.77545464
156Leukodystrophy (HP:0002415)1.77316172
157Personality changes (HP:0000751)1.77315935
158Akinesia (HP:0002304)1.77159147
159Hyperparathyroidism (HP:0000843)1.76614260
160Autoimmune thrombocytopenia (HP:0001973)1.76222601
161J-shaped sella turcica (HP:0002680)1.75593466
162Urinary incontinence (HP:0000020)1.75267730
163Amyloidosis (HP:0011034)1.75162343
164Stomatitis (HP:0010280)1.75079933
165Abnormality of the peritoneum (HP:0002585)1.74982104
166Megalencephaly (HP:0001355)1.74741115
167Absent forearm bone (HP:0003953)1.73984344
168Aplasia involving forearm bones (HP:0009822)1.73984344
169Abnormality of mucopolysaccharide metabolism (HP:0011020)1.71275759
170Abnormality of polysaccharide metabolism (HP:0011012)1.71275759
171Abnormality of glycosaminoglycan metabolism (HP:0004371)1.71275759
172Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.71005706
173Hypoplastic pelvis (HP:0008839)1.70823243
174Partial duplication of the phalanx of hand (HP:0009999)1.69804692
175Decreased lacrimation (HP:0000633)1.68648869
176Mucopolysacchariduria (HP:0008155)1.67302922
177Urinary glycosaminoglycan excretion (HP:0003541)1.67302922
178Overlapping toe (HP:0001845)1.66313319
179Hemiparesis (HP:0001269)1.65708231

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.42530691
2CDK193.74971586
3PRPF4B3.57989454
4MAP3K103.53466041
5ERN13.34636098
6TESK22.85324584
7BLK2.70144167
8MAP3K92.56051677
9MAPK152.46099197
10STK392.39475658
11MAP2K32.38141550
12BUB12.33338783
13TRIB32.31620540
14UHMK12.22233133
15SCYL22.12803270
16NTRK11.97279617
17EIF2AK11.87746537
18IRAK41.87219813
19OXSR11.85313980
20FES1.84041824
21MAPKAPK51.83633720
22RIPK11.80051695
23TBK11.77731162
24TAOK11.74412718
25PNCK1.71038257
26TAOK21.69241560
27DYRK31.68728016
28NME21.64044111
29SIK11.59900274
30PBK1.56368232
31RIPK41.54965289
32MAP3K31.52037302
33STK161.51909226
34PRKD21.51511993
35KSR21.49111209
36MAP3K131.47425732
37IRAK31.44261394
38ARAF1.41779768
39TYK21.38548507
40SIK21.38270721
41FGR1.35010646
42MATK1.31776424
43CLK11.31356433
44SMG11.30804501
45CDK121.29531823
46BTK1.26051223
47WEE11.25251052
48IKBKE1.23923164
49ACVR1B1.22405823
50ZAP701.20600978
51LIMK11.16129502
52DYRK21.15621810
53VRK11.14266886
54MAP3K141.13499967
55CDC42BPA1.12085041
56EPHB11.09415059
57MAP2K21.06577623
58MAP3K111.05181696
59CDK141.04645609
60BMPR21.04186741
61IKBKB1.02878808
62BRAF1.01199607
63CSNK1G30.98360747
64PAK60.97681016
65GRK50.97670031
66CSF1R0.97633011
67PIM20.97335414
68PDPK10.94105089
69FGFR40.92796000
70RPS6KC10.92255087
71RPS6KL10.92255087
72HCK0.90485701
73PIM10.90309208
74MAPK120.88531028
75DAPK20.88015349
76CDK11A0.86896651
77ITK0.86694711
78DAPK30.85429492
79MARK20.85065725
80PDK10.84374814
81AURKA0.83233257
82CDK150.82352054
83ALK0.81468009
84SIK30.80959644
85ICK0.80175381
86STK380.78076969
87YES10.78000617
88HIPK20.76964396
89TNIK0.76375445
90TNK20.75457421
91RPS6KA60.73773560
92CDK180.73277650
93PAK10.70561885
94RPS6KA20.69864700
95NME10.69289916
96WNK40.69220103
97IRAK20.68912209
98JAK20.68592880
99WNK10.67791395
100CDK80.67630598
101CAMK2B0.66945446
102CAMKK10.65990275
103DYRK1B0.65379588
104BCR0.64923688
105MAPK110.64758112
106CSNK1G20.64448052
107SGK30.64054692
108TEC0.63822332
109STK110.63439452
110MARK30.63207326
111TXK0.62725470
112MAP4K10.62437802
113PKN10.62360228
114JAK30.61782087
115CDK50.61357652
116MET0.61316029
117PASK0.61019456
118DYRK1A0.60253472
119RAF10.59633613
120GRK70.59072399
121CDK60.58812671
122MINK10.58451230
123GRK60.57795063
124EIF2AK30.57361089
125MAPKAPK30.57286623
126CSNK1G10.57267032
127LMTK20.56679694
128CASK0.56212711
129MAP3K50.56189638
130CDK40.54894133
131TAOK30.54118286
132IRAK10.53590887
133NTRK30.51410084
134CSNK1A1L0.50572982
135KIT0.49694175
136CSNK2A20.47856488
137LCK0.47244636
138CHUK0.47065902
139DAPK10.46179878
140ROCK20.45976442
141SYK0.45590430
142RPS6KA50.45305407
143CDK90.44684602
144RPS6KA10.44657797
145JAK10.44069071
146MOS0.43387371
147CDK70.43191602
148ABL20.42314213
149TYRO30.41492945
150MAP3K80.40525901
151CAMK2D0.38967852
152PRKCH0.38916764
153FLT30.38858490
154MARK10.38580460
155MAP3K10.38249014
156FGFR30.38132489
157LRRK20.37967129
158CSK0.37475279
159LYN0.34205455
160PLK10.33307049
161MAP3K20.32210963
162MAPK100.31509599
163CSNK1E0.31426699

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.28810338
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.25769592
3Allograft rejection_Homo sapiens_hsa053302.76613703
4Leishmaniasis_Homo sapiens_hsa051402.68858163
5RNA polymerase_Homo sapiens_hsa030202.66632359
6Autoimmune thyroid disease_Homo sapiens_hsa053202.55307355
7Asthma_Homo sapiens_hsa053102.52221522
8DNA replication_Homo sapiens_hsa030302.48885689
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.46720328
10Graft-versus-host disease_Homo sapiens_hsa053322.42919008
11Mismatch repair_Homo sapiens_hsa034302.34573978
12Protein export_Homo sapiens_hsa030602.34222204
13Oxidative phosphorylation_Homo sapiens_hsa001902.30009521
14Staphylococcus aureus infection_Homo sapiens_hsa051502.25435221
15Osteoclast differentiation_Homo sapiens_hsa043802.12568158
16Spliceosome_Homo sapiens_hsa030402.10493912
17Steroid biosynthesis_Homo sapiens_hsa001002.03903023
18Homologous recombination_Homo sapiens_hsa034401.96300428
19Primary immunodeficiency_Homo sapiens_hsa053401.96252258
20Type I diabetes mellitus_Homo sapiens_hsa049401.94582063
21Parkinsons disease_Homo sapiens_hsa050121.92932670
22Viral myocarditis_Homo sapiens_hsa054161.77361982
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76441120
24Acute myeloid leukemia_Homo sapiens_hsa052211.75409374
25Sulfur relay system_Homo sapiens_hsa041221.68674687
26Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65146182
27Toxoplasmosis_Homo sapiens_hsa051451.64020522
28Lysosome_Homo sapiens_hsa041421.59819565
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.55765018
30Proteasome_Homo sapiens_hsa030501.55487417
31Base excision repair_Homo sapiens_hsa034101.54262082
32Synaptic vesicle cycle_Homo sapiens_hsa047211.51025222
33Vibrio cholerae infection_Homo sapiens_hsa051101.50298130
34Folate biosynthesis_Homo sapiens_hsa007901.49645932
35Influenza A_Homo sapiens_hsa051641.47073243
36Alzheimers disease_Homo sapiens_hsa050101.42837856
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.42715548
38Other glycan degradation_Homo sapiens_hsa005111.39072347
39Antigen processing and presentation_Homo sapiens_hsa046121.38743075
40Non-small cell lung cancer_Homo sapiens_hsa052231.38482107
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37761610
42Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.35759177
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.35753271
44Rheumatoid arthritis_Homo sapiens_hsa053231.34892984
45T cell receptor signaling pathway_Homo sapiens_hsa046601.34639721
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.33668386
47Pyrimidine metabolism_Homo sapiens_hsa002401.32406301
48Ether lipid metabolism_Homo sapiens_hsa005651.31995579
49Nucleotide excision repair_Homo sapiens_hsa034201.31094704
50Herpes simplex infection_Homo sapiens_hsa051681.30895249
51B cell receptor signaling pathway_Homo sapiens_hsa046621.30351055
52Huntingtons disease_Homo sapiens_hsa050161.26247316
53Chronic myeloid leukemia_Homo sapiens_hsa052201.24164032
54Notch signaling pathway_Homo sapiens_hsa043301.20726397
55TNF signaling pathway_Homo sapiens_hsa046681.18274956
56Hepatitis B_Homo sapiens_hsa051611.17455389
57Long-term depression_Homo sapiens_hsa047301.15688521
58Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15247698
59Sphingolipid metabolism_Homo sapiens_hsa006001.12445208
60Sphingolipid signaling pathway_Homo sapiens_hsa040711.11383763
61Collecting duct acid secretion_Homo sapiens_hsa049661.10414081
62Chemokine signaling pathway_Homo sapiens_hsa040621.06530015
63Glycosaminoglycan degradation_Homo sapiens_hsa005311.06251289
64Hematopoietic cell lineage_Homo sapiens_hsa046401.03381394
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03181120
66Hepatitis C_Homo sapiens_hsa051601.02453599
67RNA transport_Homo sapiens_hsa030131.01076624
68Apoptosis_Homo sapiens_hsa042101.00625727
69Alcoholism_Homo sapiens_hsa050340.99923493
70Measles_Homo sapiens_hsa051620.96632436
71Renal cell carcinoma_Homo sapiens_hsa052110.95227318
72Endocytosis_Homo sapiens_hsa041440.92798733
73Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92121087
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91895644
75Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.91558890
76NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90642262
77Pancreatic cancer_Homo sapiens_hsa052120.89292740
78Non-homologous end-joining_Homo sapiens_hsa034500.88016380
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87405222
80* Phosphatidylinositol signaling system_Homo sapiens_hsa040700.82617642
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81673261
82Cocaine addiction_Homo sapiens_hsa050300.79443801
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.79311472
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78862942
85Oocyte meiosis_Homo sapiens_hsa041140.78202543
86Dopaminergic synapse_Homo sapiens_hsa047280.77986920
87Endometrial cancer_Homo sapiens_hsa052130.77669861
88Prolactin signaling pathway_Homo sapiens_hsa049170.77534960
89Epstein-Barr virus infection_Homo sapiens_hsa051690.77314303
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.75500044
91HTLV-I infection_Homo sapiens_hsa051660.75291858
92Malaria_Homo sapiens_hsa051440.74634752
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74577927
94Fatty acid elongation_Homo sapiens_hsa000620.74173914
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73858665
96Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73637849
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.72849777
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70314970
99Legionellosis_Homo sapiens_hsa051340.69157528
100Serotonergic synapse_Homo sapiens_hsa047260.69081155
101MAPK signaling pathway_Homo sapiens_hsa040100.68923068
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.68272227
103Long-term potentiation_Homo sapiens_hsa047200.67936028
104Axon guidance_Homo sapiens_hsa043600.67636585
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66888120
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.66886930
107Inositol phosphate metabolism_Homo sapiens_hsa005620.65635697
108Basal transcription factors_Homo sapiens_hsa030220.65348243
109Fanconi anemia pathway_Homo sapiens_hsa034600.64075664
110Prion diseases_Homo sapiens_hsa050200.63738032
111FoxO signaling pathway_Homo sapiens_hsa040680.63572627
112Phagosome_Homo sapiens_hsa041450.63241902
113Shigellosis_Homo sapiens_hsa051310.62749129
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62381964
115Glutamatergic synapse_Homo sapiens_hsa047240.61684710
116VEGF signaling pathway_Homo sapiens_hsa043700.61448228
117Viral carcinogenesis_Homo sapiens_hsa052030.61098621
118ErbB signaling pathway_Homo sapiens_hsa040120.59492430
119GABAergic synapse_Homo sapiens_hsa047270.58325462
120Gap junction_Homo sapiens_hsa045400.56491484
121Cholinergic synapse_Homo sapiens_hsa047250.55882476
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55424303
123Neurotrophin signaling pathway_Homo sapiens_hsa047220.54370344
124mTOR signaling pathway_Homo sapiens_hsa041500.54019561
125Amphetamine addiction_Homo sapiens_hsa050310.52785636
126Adipocytokine signaling pathway_Homo sapiens_hsa049200.52634128
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52573943
128GnRH signaling pathway_Homo sapiens_hsa049120.52032688
129Colorectal cancer_Homo sapiens_hsa052100.51548283
130mRNA surveillance pathway_Homo sapiens_hsa030150.51461248
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.50199625
132HIF-1 signaling pathway_Homo sapiens_hsa040660.49730457
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.49152031
134Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49128167
135Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48236642
136Insulin signaling pathway_Homo sapiens_hsa049100.48133493
137Platelet activation_Homo sapiens_hsa046110.47179586
138Transcriptional misregulation in cancer_Homo sapiens_hsa052020.46438961
139Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.46217139
140Tuberculosis_Homo sapiens_hsa051520.45899275
141Bladder cancer_Homo sapiens_hsa052190.45890080
142Regulation of autophagy_Homo sapiens_hsa041400.45789653
143Maturity onset diabetes of the young_Homo sapiens_hsa049500.45367705
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45265762
145Purine metabolism_Homo sapiens_hsa002300.44710594
146Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42335223
147Salmonella infection_Homo sapiens_hsa051320.41552782
148Estrogen signaling pathway_Homo sapiens_hsa049150.41445097
149Morphine addiction_Homo sapiens_hsa050320.41324795
150Pertussis_Homo sapiens_hsa051330.41257540
151Prostate cancer_Homo sapiens_hsa052150.41155345
152Systemic lupus erythematosus_Homo sapiens_hsa053220.41083990
153One carbon pool by folate_Homo sapiens_hsa006700.40957655
154Dorso-ventral axis formation_Homo sapiens_hsa043200.40934993
155Cell cycle_Homo sapiens_hsa041100.40907375
156Nicotine addiction_Homo sapiens_hsa050330.40382782
157Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40098887
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39568111
159Glioma_Homo sapiens_hsa052140.38903056
160Ras signaling pathway_Homo sapiens_hsa040140.37947349
161Choline metabolism in cancer_Homo sapiens_hsa052310.37938644
162Glycerophospholipid metabolism_Homo sapiens_hsa005640.35146531
163Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34895513
164Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33992753
165Pancreatic secretion_Homo sapiens_hsa049720.33949010

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