TMEM55A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: TMEM55A catalyzes the degradation of phosphatidylinositol 4,5-bisphosphate (PtdIns-4,5-P2) by removing the 4-phosphate (Ungewickell et al., 2005 [PubMed 16365287]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neutrophil activation involved in immune response (GO:0002283)6.19423422
2cullin deneddylation (GO:0010388)5.93646614
3leukocyte migration involved in inflammatory response (GO:0002523)5.46243497
4protein deneddylation (GO:0000338)5.34202052
5negative regulation of heart rate (GO:0010459)5.25327573
6thrombin receptor signaling pathway (GO:0070493)5.20089457
7negative regulation of dendrite morphogenesis (GO:0050774)4.82378491
8regulation of platelet aggregation (GO:0090330)4.62210438
9heart process (GO:0003015)4.33425627
10heart contraction (GO:0060047)4.33425627
11regulation of platelet activation (GO:0010543)4.20976301
12positive regulation of mitochondrial fission (GO:0090141)4.17404690
13neutrophil activation (GO:0042119)4.14450990
14negative regulation of appetite (GO:0032099)4.03169802
15negative regulation of response to food (GO:0032096)4.03169802
16positive regulation of mast cell activation (GO:0033005)3.95775473
17regulation of Golgi to plasma membrane protein transport (GO:0042996)3.85291308
18platelet dense granule organization (GO:0060155)3.73800624
19negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.68546188
20negative regulation of norepinephrine secretion (GO:0010700)3.66516047
21relaxation of smooth muscle (GO:0044557)3.64996082
22regulation of integrin-mediated signaling pathway (GO:2001044)3.64093236
23sequestering of actin monomers (GO:0042989)3.61992023
24dopamine transport (GO:0015872)3.60638370
25protein neddylation (GO:0045116)3.48475737
26lipoxygenase pathway (GO:0019372)3.46855797
27regulation of MHC class II biosynthetic process (GO:0045346)3.44300880
28oxidative phosphorylation (GO:0006119)3.43774973
29granulocyte activation (GO:0036230)3.41543522
30platelet aggregation (GO:0070527)3.38323468
31regulation of translational termination (GO:0006449)3.37702026
32respiratory chain complex IV assembly (GO:0008535)3.36668220
33negative regulation of striated muscle cell apoptotic process (GO:0010664)3.35577385
34adenosine receptor signaling pathway (GO:0001973)3.35026858
35negative regulation of calcium ion transmembrane transport (GO:1903170)3.34527586
36negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.34527586
37long-chain fatty acid biosynthetic process (GO:0042759)3.33673561
38protein retention in ER lumen (GO:0006621)3.21297946
39metanephric mesenchyme development (GO:0072075)3.18439010
40cytochrome complex assembly (GO:0017004)3.18114366
41negative regulation of heart contraction (GO:0045822)3.17367348
42phagocytosis, engulfment (GO:0006911)3.15910183
43negative regulation of cation channel activity (GO:2001258)3.13174618
44G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.12341994
45intraciliary transport (GO:0042073)3.12103849
46protein complex biogenesis (GO:0070271)3.10945551
47blood coagulation, intrinsic pathway (GO:0007597)3.07967968
48purinergic nucleotide receptor signaling pathway (GO:0035590)3.07779056
49negative regulation of synaptic transmission, GABAergic (GO:0032229)3.06726095
50mitochondrial respiratory chain complex I assembly (GO:0032981)3.06052445
51NADH dehydrogenase complex assembly (GO:0010257)3.06052445
52mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.06052445
53maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04983446
54neuronal action potential propagation (GO:0019227)3.04424113
55negative regulation of platelet activation (GO:0010544)3.01766823
56polyamine biosynthetic process (GO:0006596)3.01625382
57negative regulation of catecholamine secretion (GO:0033604)3.01459155
58negative regulation of dendrite development (GO:2000171)2.98232296
59viral mRNA export from host cell nucleus (GO:0046784)2.98213124
60kidney mesenchyme development (GO:0072074)2.95839718
61ventricular trabecula myocardium morphogenesis (GO:0003222)2.95230653
62microglial cell activation (GO:0001774)2.94111662
63negative regulation of thymocyte apoptotic process (GO:0070244)2.90546705
64neurotransmitter uptake (GO:0001504)2.85140957
65sequestering of extracellular ligand from receptor (GO:0035581)2.84770657
66positive regulation of endothelial cell differentiation (GO:0045603)2.84410981
67adenosine metabolic process (GO:0046085)2.82614619
68behavioral response to cocaine (GO:0048148)2.81177201
69regulation of mast cell activation (GO:0033003)2.78893701
70positive regulation of protein homodimerization activity (GO:0090073)2.78759234
71leukocyte degranulation (GO:0043299)2.75851417
72negative regulation of muscle contraction (GO:0045932)2.75770845
73tricarboxylic acid cycle (GO:0006099)2.75666424
74deoxyribose phosphate biosynthetic process (GO:0046385)2.75213146
752-deoxyribonucleotide biosynthetic process (GO:0009265)2.75213146
767-methylguanosine mRNA capping (GO:0006370)2.74924165
77positive regulation of cAMP-mediated signaling (GO:0043950)2.74797294
78positive regulation of mast cell activation involved in immune response (GO:0033008)2.73470135
79positive regulation of mast cell degranulation (GO:0043306)2.73470135
80membrane invagination (GO:0010324)2.73405745
81phagosome maturation (GO:0090382)2.71715991
82positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.70216257
83drinking behavior (GO:0042756)2.69495537
847-methylguanosine RNA capping (GO:0009452)2.69402409
85RNA capping (GO:0036260)2.69402409
86negative regulation of blood circulation (GO:1903523)2.69327510
87regulation of relaxation of muscle (GO:1901077)2.68544894
88negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.67042387
89mitochondrial respiratory chain complex assembly (GO:0033108)2.65997235
90negative regulation of homotypic cell-cell adhesion (GO:0034111)2.65638674
91regulation of hexokinase activity (GO:1903299)2.63319905
92regulation of glucokinase activity (GO:0033131)2.63319905
93fatty acid elongation (GO:0030497)2.62602561
94regulation of mitochondrial fission (GO:0090140)2.60979620
95regulation of homotypic cell-cell adhesion (GO:0034110)2.60774151
96positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.60699402
97positive regulation of toll-like receptor signaling pathway (GO:0034123)2.60007080
98regulation of memory T cell differentiation (GO:0043380)2.58760618
99regulation of cAMP-dependent protein kinase activity (GO:2000479)2.58148016
100protein localization to microtubule (GO:0035372)2.57812956
101homotypic cell-cell adhesion (GO:0034109)2.56449786
102paraxial mesoderm development (GO:0048339)2.56395308
103regulation of response to food (GO:0032095)2.55522681
104chaperone-mediated protein folding (GO:0061077)2.55474289
105transferrin transport (GO:0033572)2.55385936
106glomerulus development (GO:0032835)2.55122253
107muscle filament sliding (GO:0030049)2.54953587
108actin-myosin filament sliding (GO:0033275)2.54953587
109serotonin receptor signaling pathway (GO:0007210)2.54074004
110regulation of synaptic vesicle exocytosis (GO:2000300)2.54049777
111purine-containing compound salvage (GO:0043101)2.53959250
112extracellular negative regulation of signal transduction (GO:1900116)2.53479668
113extracellular regulation of signal transduction (GO:1900115)2.53479668
114negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.53269967
115proteasome assembly (GO:0043248)2.52760129
116peripheral nervous system neuron development (GO:0048935)2.51883854
117actin-mediated cell contraction (GO:0070252)2.51338770
118negative regulation of protein localization to cell surface (GO:2000009)2.51009395
119triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.50849717
120regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.49679251
121atrial septum morphogenesis (GO:0060413)2.49466967
122negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.48957036
123cardiac right ventricle morphogenesis (GO:0003215)2.48930238
124regulation of dopamine metabolic process (GO:0042053)2.48784174
125regulation of catecholamine metabolic process (GO:0042069)2.48784174
126fusion of sperm to egg plasma membrane (GO:0007342)2.48590734
127aerobic respiration (GO:0009060)2.48452050
128negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.48101815
129regulation of cardiac muscle cell apoptotic process (GO:0010665)2.46903026
130monoamine transport (GO:0015844)2.46825083
131ribonucleoprotein complex disassembly (GO:0032988)2.45295013
132heart trabecula morphogenesis (GO:0061384)2.44915704
133extracellular fibril organization (GO:0043206)2.44835324
134superoxide anion generation (GO:0042554)2.43968001
135positive regulation of microtubule polymerization (GO:0031116)2.43654741
136dendritic cell chemotaxis (GO:0002407)2.42516975
137kidney morphogenesis (GO:0060993)2.42480595
138regulation of striated muscle cell apoptotic process (GO:0010662)2.42396641
139cellular extravasation (GO:0045123)2.41834352
140negative regulation of cardiac muscle hypertrophy (GO:0010614)2.41570945
141positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.41243817
142cell differentiation involved in metanephros development (GO:0072202)2.40802423
143regulation of G0 to G1 transition (GO:0070316)2.40547467
144cellular biogenic amine biosynthetic process (GO:0042401)2.40545473
145purinergic receptor signaling pathway (GO:0035587)2.39590870
146antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.39148131
147ferric iron transport (GO:0015682)2.38852263
148trivalent inorganic cation transport (GO:0072512)2.38852263
149positive regulation of myoblast differentiation (GO:0045663)2.37956440
150cellular respiration (GO:0045333)2.37888990
151cyclooxygenase pathway (GO:0019371)2.37446222
152regulation of inositol phosphate biosynthetic process (GO:0010919)2.37098918
153viral protein processing (GO:0019082)2.36842087
154dendritic cell migration (GO:0036336)2.36467375
155cardiac muscle tissue morphogenesis (GO:0055008)2.36044486
156negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.35769914
157termination of G-protein coupled receptor signaling pathway (GO:0038032)2.35337187
158regulation of acyl-CoA biosynthetic process (GO:0050812)2.35133905
159melanosome transport (GO:0032402)2.34641288
160regulation of clathrin-mediated endocytosis (GO:2000369)2.34474914
161negative regulation of neurotransmitter transport (GO:0051589)2.34006513
162membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.33998982
163regulation of synaptic vesicle transport (GO:1902803)2.33720256
164respiratory tube development (GO:0030323)2.33691921
165chaperone-mediated protein transport (GO:0072321)2.32466043
166ATP hydrolysis coupled proton transport (GO:0015991)2.31976030
167energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.31976030
168positive regulation of male gonad development (GO:2000020)2.30985216
169chondrocyte proliferation (GO:0035988)2.30888990
170polyketide metabolic process (GO:0030638)2.29387457
171doxorubicin metabolic process (GO:0044598)2.29387457
172daunorubicin metabolic process (GO:0044597)2.29387457
173urinary tract smooth muscle contraction (GO:0014848)2.29357402
174generation of neurons (GO:0048699)2.29121127
175mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.29077055
176ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.27666303
177outflow tract septum morphogenesis (GO:0003148)2.27323648
178metanephros development (GO:0001656)2.27278216
179deoxyribonucleotide biosynthetic process (GO:0009263)2.27269082
180positive regulation of cardiac muscle cell proliferation (GO:0060045)2.26343399
181tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.25639885
182RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.25639885
183purine nucleobase biosynthetic process (GO:0009113)2.25526599
184cardiac myofibril assembly (GO:0055003)2.24168435
185mesenchymal cell differentiation involved in kidney development (GO:0072161)2.24122104
186mesenchymal cell differentiation involved in renal system development (GO:2001012)2.24122104
187neuron projection extension involved in neuron projection guidance (GO:1902284)2.23760780
188axon extension involved in axon guidance (GO:0048846)2.23760780
189negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.23430618
190protein peptidyl-prolyl isomerization (GO:0000413)2.23392009
191negative regulation of glycogen biosynthetic process (GO:0045719)2.23351676
192regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.22641824

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse6.95007136
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99329089
3EZH2_22144423_ChIP-Seq_EOC_Human3.23846124
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.16710360
5LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.59021092
6EST1_17652178_ChIP-ChIP_JURKAT_Human2.55665069
7CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51347626
8HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.39839930
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35996511
10GBX2_23144817_ChIP-Seq_PC3_Human2.34393133
11SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.33210098
12SRF_21415370_ChIP-Seq_HL-1_Mouse2.23975659
13PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21308391
14WT1_19549856_ChIP-ChIP_CCG9911_Human2.16398310
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.14651556
16IGF1R_20145208_ChIP-Seq_DFB_Human2.12577431
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.10687761
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02955303
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.01990201
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.01583656
21PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.95299437
22ELK1_19687146_ChIP-ChIP_HELA_Human1.94325274
23IRF8_21731497_ChIP-ChIP_J774_Mouse1.85601328
24CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85567250
25ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85229957
26PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.83972746
27THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83830017
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.81315699
29HTT_18923047_ChIP-ChIP_STHdh_Human1.81035248
30NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.78940261
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.78853963
32FUS_26573619_Chip-Seq_HEK293_Human1.78721103
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78718419
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.71866907
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67593399
36UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.66506198
37IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66109725
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61908332
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.60817905
40BP1_19119308_ChIP-ChIP_Hs578T_Human1.60121279
41TP63_19390658_ChIP-ChIP_HaCaT_Human1.59407176
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.59154755
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.57752064
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.57590979
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.57427021
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56099498
47SUZ12_27294783_Chip-Seq_NPCs_Mouse1.55272732
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54193461
49MYC_19030024_ChIP-ChIP_MESCs_Mouse1.53901036
50* P300_19829295_ChIP-Seq_ESCs_Human1.53460978
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53064758
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52399660
53EWS_26573619_Chip-Seq_HEK293_Human1.51460206
54JUN_21703547_ChIP-Seq_K562_Human1.49772342
55GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49054529
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48682386
57CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.48437418
58LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.47136755
59ER_23166858_ChIP-Seq_MCF-7_Human1.47039870
60* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.42085572
61ZNF274_21170338_ChIP-Seq_K562_Hela1.42063532
62AR_25329375_ChIP-Seq_VCAP_Human1.40514868
63KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.39966626
64SCL_19346495_ChIP-Seq_HPC-7_Human1.39252405
65BCAT_22108803_ChIP-Seq_LS180_Human1.38364147
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.38203260
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.37404553
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.36433550
69* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.35966766
70ETS1_20019798_ChIP-Seq_JURKAT_Human1.35882415
71PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34697477
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34583418
73* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.33674728
74* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.33451345
75CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32988226
76* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32276756
77VDR_22108803_ChIP-Seq_LS180_Human1.31554154
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.31445367
79* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.30147614
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.29836620
81TAF15_26573619_Chip-Seq_HEK293_Human1.29700486
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.28799780
83ESR1_20079471_ChIP-ChIP_T-47D_Human1.28575606
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.28357845
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28294677
86* SALL4_22934838_ChIP-ChIP_CD34+_Human1.27741164
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.27547347
88KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27132610
89TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.26928377
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26896749
91GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.26477867
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26218809
93AR_21909140_ChIP-Seq_LNCAP_Human1.24673345
94NANOG_18555785_Chip-Seq_ESCs_Mouse1.24150400
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23850795
96* SOX2_19829295_ChIP-Seq_ESCs_Human1.23797691
97* NANOG_19829295_ChIP-Seq_ESCs_Human1.23797691
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.21980798
99HOXB4_20404135_ChIP-ChIP_EML_Mouse1.21192214
100* P53_22387025_ChIP-Seq_ESCs_Mouse1.21179273
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.20861056
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20197217
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20197217
104EP300_21415370_ChIP-Seq_HL-1_Mouse1.19010682
105SMAD4_21799915_ChIP-Seq_A2780_Human1.18565877
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.18304658
107CRX_20693478_ChIP-Seq_RETINA_Mouse1.18185167
108EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.17567243
109MYC_18358816_ChIP-ChIP_MESCs_Mouse1.15809011
110VDR_23849224_ChIP-Seq_CD4+_Human1.14517652
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13630302
112RNF2_27304074_Chip-Seq_NSC_Mouse1.13581041
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13251147
114* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13249588
115CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12242898
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.12133658
117TAL1_26923725_Chip-Seq_HPCs_Mouse1.11882721
118EED_16625203_ChIP-ChIP_MESCs_Mouse1.11353384
119NANOG_16153702_ChIP-ChIP_HESCs_Human1.11221582
120DCP1A_22483619_ChIP-Seq_HELA_Human1.10784443
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09319032
122E2F1_18555785_Chip-Seq_ESCs_Mouse1.09272101
123CMYC_18555785_Chip-Seq_ESCs_Mouse1.08853456
124MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08683676
125FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08289248
126MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08259079
127EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.08207679
128STAT3_23295773_ChIP-Seq_U87_Human1.07797235
129TRIM28_21343339_ChIP-Seq_HEK293_Human1.07353511
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.07210524
131FLI1_27457419_Chip-Seq_LIVER_Mouse1.06791941
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06749263
133SOX17_20123909_ChIP-Seq_XEN_Mouse1.06301042
134SPI1_23127762_ChIP-Seq_K562_Human1.06175742
135TTF2_22483619_ChIP-Seq_HELA_Human1.05376615
136TCF4_23295773_ChIP-Seq_U87_Human1.05008560
137TP53_22573176_ChIP-Seq_HFKS_Human1.04963219
138SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04938762
139SMAD_19615063_ChIP-ChIP_OVARY_Human1.04924565
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04313285
141OCT4_21477851_ChIP-Seq_ESCs_Mouse1.03565132
142NANOG_21062744_ChIP-ChIP_HESCs_Human1.02505847
143PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02083529
144E2F7_22180533_ChIP-Seq_HELA_Human1.01732355
145SUZ12_18555785_Chip-Seq_ESCs_Mouse1.01460443
146ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.00780957
147IRF8_27001747_Chip-Seq_BMDM_Mouse1.00776719
148RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.99997485
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.99846546
150YY1_21170310_ChIP-Seq_MESCs_Mouse0.97913532
151DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97873090
152PRDM14_20953172_ChIP-Seq_ESCs_Human0.97738946
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.97301268
154* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96928975
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.96783819
156FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96783819
157SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95889455
158MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.95716516
159SOX9_26525672_Chip-Seq_HEART_Mouse0.95339173
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95065198
161SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.94905183
162SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94551727
163STAT3_18555785_Chip-Seq_ESCs_Mouse0.94226363
164EZH2_27304074_Chip-Seq_ESCs_Mouse0.93751911
165* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93119988
166* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93119988
167RARG_19884340_ChIP-ChIP_MEFs_Mouse0.92970726
168ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92909094
169IRF1_19129219_ChIP-ChIP_H3396_Human0.92742640
170* ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92718593
171RUNX2_22187159_ChIP-Seq_PCA_Human0.92526855
172TCF4_22108803_ChIP-Seq_LS180_Human0.91905453
173* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.91252756
174CBP_20019798_ChIP-Seq_JUKART_Human0.90997628

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology6.10038263
2MP0003724_increased_susceptibility_to4.34350687
3MP0003122_maternal_imprinting3.71368866
4MP0008004_abnormal_stomach_pH3.56515960
5MP0002102_abnormal_ear_morphology3.42334367
6MP0008789_abnormal_olfactory_epithelium2.72886325
7MP0009697_abnormal_copulation2.72844236
8MP0008877_abnormal_DNA_methylation2.52438151
9MP0003123_paternal_imprinting2.47507231
10MP0003121_genomic_imprinting2.42491495
11MP0005394_taste/olfaction_phenotype2.39604029
12MP0005499_abnormal_olfactory_system2.39604029
13MP0010030_abnormal_orbit_morphology2.30499545
14MP0000465_gastrointestinal_hemorrhage2.30023630
15MP0004510_myositis2.23841596
16MP0005171_absent_coat_pigmentation2.20669602
17MP0003941_abnormal_skin_development2.08038352
18MP0001986_abnormal_taste_sensitivity2.06388526
19MP0001984_abnormal_olfaction2.05064396
20MP0005503_abnormal_tendon_morphology2.03889217
21MP0003880_abnormal_central_pattern2.00314582
22MP0005084_abnormal_gallbladder_morpholo1.97828320
23MP0000343_altered_response_to1.95680083
24MP0000372_irregular_coat_pigmentation1.94012959
25MP0000749_muscle_degeneration1.93546177
26MP0002938_white_spotting1.93429656
27MP0001529_abnormal_vocalization1.87587516
28MP0002735_abnormal_chemical_nociception1.87023521
29MP0004859_abnormal_synaptic_plasticity1.85008095
30MP0003787_abnormal_imprinting1.80338495
31MP0009046_muscle_twitch1.80173244
32MP0009250_abnormal_appendicular_skeleto1.79945647
33MP0003942_abnormal_urinary_system1.79380720
34MP0000566_synostosis1.78816435
35MP0002733_abnormal_thermal_nociception1.76844422
36MP0005646_abnormal_pituitary_gland1.75121413
37MP0003828_pulmonary_edema1.68031807
38MP0003279_aneurysm1.67322398
39MP0004084_abnormal_cardiac_muscle1.66029142
40MP0004782_abnormal_surfactant_physiolog1.63352313
41MP0001188_hyperpigmentation1.62667695
42MP0006035_abnormal_mitochondrial_morpho1.59440521
43MP0001970_abnormal_pain_threshold1.59402098
44MP0009053_abnormal_anal_canal1.58936168
45MP0000049_abnormal_middle_ear1.58538064
46MP0002272_abnormal_nervous_system1.56899513
47MP0009745_abnormal_behavioral_response1.55687329
48MP0000230_abnormal_systemic_arterial1.55082780
49MP0002736_abnormal_nociception_after1.53007806
50MP0008438_abnormal_cutaneous_collagen1.51121191
51MP0003136_yellow_coat_color1.50596682
52MP0001542_abnormal_bone_strength1.50451597
53MP0003303_peritoneal_inflammation1.48102689
54MP0003011_delayed_dark_adaptation1.47200213
55MP0005367_renal/urinary_system_phenotyp1.45687255
56MP0000516_abnormal_urinary_system1.45687255
57MP0002877_abnormal_melanocyte_morpholog1.44491753
58MP0003115_abnormal_respiratory_system1.44068247
59MP0001177_atelectasis1.42487045
60MP0002972_abnormal_cardiac_muscle1.41547292
61MP0004142_abnormal_muscle_tone1.41183232
62MP0003635_abnormal_synaptic_transmissio1.40769886
63MP0003385_abnormal_body_wall1.39525663
64MP0008775_abnormal_heart_ventricle1.38767315
65MP0002751_abnormal_autonomic_nervous1.37817142
66MP0001486_abnormal_startle_reflex1.37413032
67MP0006036_abnormal_mitochondrial_physio1.36171075
68MP0000534_abnormal_ureter_morphology1.33724507
69MP0001968_abnormal_touch/_nociception1.32848673
70MP0001905_abnormal_dopamine_level1.32336629
71MP0002734_abnormal_mechanical_nocicepti1.31939163
72MP0008872_abnormal_physiological_respon1.29641628
73MP0003315_abnormal_perineum_morphology1.28249214
74MP0004133_heterotaxia1.27632806
75MP0006276_abnormal_autonomic_nervous1.26952101
76MP0002822_catalepsy1.25405329
77MP0009780_abnormal_chondrocyte_physiolo1.24661023
78MP0005248_abnormal_Harderian_gland1.23994783
79MP0005167_abnormal_blood-brain_barrier1.23122804
80MP0006054_spinal_hemorrhage1.20905439
81MP0002160_abnormal_reproductive_system1.20618442
82MP0003890_abnormal_embryonic-extraembry1.20200809
83MP0002064_seizures1.20004652
84MP0008007_abnormal_cellular_replicative1.19426752
85MP0001835_abnormal_antigen_presentation1.18942369
86MP0002638_abnormal_pupillary_reflex1.17549811
87MP0002653_abnormal_ependyma_morphology1.17455093
88MP0009384_cardiac_valve_regurgitation1.14358380
89MP0004215_abnormal_myocardial_fiber1.13641902
90MP0002067_abnormal_sensory_capabilities1.13373466
91MP0005174_abnormal_tail_pigmentation1.10712396
92MP0005508_abnormal_skeleton_morphology1.09168908
93MP0003943_abnormal_hepatobiliary_system1.08794023
94MP0005410_abnormal_fertilization1.08548045
95MP0003755_abnormal_palate_morphology1.08182410
96MP0009764_decreased_sensitivity_to1.07782474
97MP0002132_abnormal_respiratory_system1.07423371
98MP0008932_abnormal_embryonic_tissue1.06095828
99MP0004484_altered_response_of1.05444433
100MP0002572_abnormal_emotion/affect_behav1.05381248
101MP0005671_abnormal_response_to1.05320169
102MP0003638_abnormal_response/metabolism_1.05116757
103MP0000569_abnormal_digit_pigmentation1.04637902
104MP0005551_abnormal_eye_electrophysiolog1.04526865
105MP0002063_abnormal_learning/memory/cond1.03445458
106MP0005408_hypopigmentation1.02436310
107MP0002009_preneoplasia1.01076267
108MP0004085_abnormal_heartbeat0.98672430
109MP0002876_abnormal_thyroid_physiology0.98150197
110MP0008058_abnormal_DNA_repair0.97886534
111MP0005377_hearing/vestibular/ear_phenot0.97363995
112MP0003878_abnormal_ear_physiology0.97363995
113MP0001879_abnormal_lymphatic_vessel0.97240581
114MP0005389_reproductive_system_phenotype0.96326028
115MP0002127_abnormal_cardiovascular_syste0.95822106
116MP0002090_abnormal_vision0.95426842
117MP0003879_abnormal_hair_cell0.95406256
118MP0005645_abnormal_hypothalamus_physiol0.95045797
119MP0005075_abnormal_melanosome_morpholog0.93819714
120MP0002282_abnormal_trachea_morphology0.93421259
121MP0002233_abnormal_nose_morphology0.91805096
122MP0006138_congestive_heart_failure0.91613615
123MP0000762_abnormal_tongue_morphology0.91195512
124MP0004130_abnormal_muscle_cell0.90735901
125MP0008874_decreased_physiological_sensi0.90481682
126MP0002109_abnormal_limb_morphology0.90454683
127MP0004134_abnormal_chest_morphology0.89519495
128MP0001919_abnormal_reproductive_system0.89508474
129MP0002249_abnormal_larynx_morphology0.89437533
130MP0004147_increased_porphyrin_level0.88793268
131MP0005620_abnormal_muscle_contractility0.88027911
132MP0004883_abnormal_blood_vessel0.86822824
133MP0005253_abnormal_eye_physiology0.86126993
134MP0002277_abnormal_respiratory_mucosa0.85691353
135MP0001851_eye_inflammation0.84592915
136MP0003119_abnormal_digestive_system0.84464704
137MP0001485_abnormal_pinna_reflex0.84342362
138MP0004233_abnormal_muscle_weight0.83641220
139MP0008569_lethality_at_weaning0.82742163
140MP0000358_abnormal_cell_content/0.81986189
141MP0000631_abnormal_neuroendocrine_gland0.81828942
142MP0003186_abnormal_redox_activity0.81513837
143MP0004036_abnormal_muscle_relaxation0.81260886
144MP0000678_abnormal_parathyroid_gland0.81235499
145MP0002177_abnormal_outer_ear0.81075166
146MP0004885_abnormal_endolymph0.81006321
147MP0003786_premature_aging0.80828324
148MP0000015_abnormal_ear_pigmentation0.78147578
149MP0005000_abnormal_immune_tolerance0.78126858
150MP0005535_abnormal_body_temperature0.77960882
151MP0001533_abnormal_skeleton_physiology0.77704953
152MP0003937_abnormal_limbs/digits/tail_de0.77464970
153MP0002116_abnormal_craniofacial_bone0.76477196
154MP0002419_abnormal_innate_immunity0.76209815
155MP0004272_abnormal_basement_membrane0.76117623
156MP0003866_abnormal_defecation0.75733051
157MP0002837_dystrophic_cardiac_calcinosis0.75505541
158MP0004957_abnormal_blastocyst_morpholog0.74951028
159MP0009763_increased_sensitivity_to0.74246993
160MP0000428_abnormal_craniofacial_morphol0.73959238
161MP0000681_abnormal_thyroid_gland0.73834135
162MP0001958_emphysema0.73346879
163MP0001544_abnormal_cardiovascular_syste0.72989778
164MP0005385_cardiovascular_system_phenoty0.72989778
165MP0006292_abnormal_olfactory_placode0.72370660
166MP0002148_abnormal_hypersensitivity_rea0.71753052
167MP0001270_distended_abdomen0.70896850
168MP0002398_abnormal_bone_marrow0.70737583
169MP0000026_abnormal_inner_ear0.70176592
170MP0006072_abnormal_retinal_apoptosis0.69296156
171MP0002723_abnormal_immune_serum0.68854226
172MP0003633_abnormal_nervous_system0.66032641
173MP0008260_abnormal_autophagy0.64951849

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.54712637
2Increased mean platelet volume (HP:0011877)6.63948067
3Abnormal platelet volume (HP:0011876)6.41561145
4Petechiae (HP:0000967)6.36329712
5Menorrhagia (HP:0000132)6.26415332
6Purpura (HP:0000979)5.20592514
7Epistaxis (HP:0000421)4.82256346
8Gingival bleeding (HP:0000225)4.29212350
9Hyperlipoproteinemia (HP:0010980)3.57664247
10Dyschromatopsia (HP:0007641)3.46416214
11Impaired platelet aggregation (HP:0003540)3.42118292
12Abnormal platelet function (HP:0011869)3.42118292
13Hypoplastic left heart (HP:0004383)3.35701419
14Hypothermia (HP:0002045)3.34328175
15Asymmetry of the thorax (HP:0001555)3.33239607
16Abnormal pupillary function (HP:0007686)3.10408519
17Atonic seizures (HP:0010819)3.06984034
18Acute necrotizing encephalopathy (HP:0006965)3.05018066
19True hermaphroditism (HP:0010459)3.02920828
20Spontaneous hematomas (HP:0007420)3.01556633
21Tubulointerstitial nephritis (HP:0001970)3.01051092
22Abnormality of the heme biosynthetic pathway (HP:0010472)2.99065522
23Upper limb muscle weakness (HP:0003484)2.97753693
24Polyphagia (HP:0002591)2.94054327
25Abnormal hair whorl (HP:0010721)2.90015259
26Hypoplastic heart (HP:0001961)2.87251599
27Abnormality of incisor morphology (HP:0011063)2.82023716
28Neoplasm of the adrenal gland (HP:0100631)2.80647548
29Myokymia (HP:0002411)2.79192647
30Abnormal mitochondria in muscle tissue (HP:0008316)2.78410828
31Febrile seizures (HP:0002373)2.78108785
323-Methylglutaconic aciduria (HP:0003535)2.75610524
33Mitochondrial inheritance (HP:0001427)2.69470079
34Increased CSF lactate (HP:0002490)2.69348894
35Progressive macrocephaly (HP:0004481)2.62684694
36Increased serum pyruvate (HP:0003542)2.59599807
37Abnormality of glycolysis (HP:0004366)2.59599807
38Hepatoblastoma (HP:0002884)2.58283379
39Spinal cord lesions (HP:0100561)2.57868588
40Syringomyelia (HP:0003396)2.57868588
41Abnormality of the lacrimal duct (HP:0011481)2.52875335
42Poor coordination (HP:0002370)2.51781722
43Congenital primary aphakia (HP:0007707)2.51243120
44Nephrogenic diabetes insipidus (HP:0009806)2.50321441
45Stomatitis (HP:0010280)2.50278721
46Pancreatic fibrosis (HP:0100732)2.49560693
47Episodic fever (HP:0001954)2.49323516
48Poikilocytosis (HP:0004447)2.47814152
49Gait imbalance (HP:0002141)2.47779244
50Abnormality of lateral ventricle (HP:0030047)2.46257167
51Abnormality of the nasolacrimal system (HP:0000614)2.43844765
52Medial flaring of the eyebrow (HP:0010747)2.43286732
53Decreased central vision (HP:0007663)2.42013342
54Abnormality of the aortic arch (HP:0012303)2.40506335
55Embryonal renal neoplasm (HP:0011794)2.37380307
56Hypoglycemic coma (HP:0001325)2.35896026
57Renal Fanconi syndrome (HP:0001994)2.35660331
58Exertional dyspnea (HP:0002875)2.33564536
59Nephroblastoma (Wilms tumor) (HP:0002667)2.32877793
60Pheochromocytoma (HP:0002666)2.29191080
61Nasolacrimal duct obstruction (HP:0000579)2.27696913
62Acanthocytosis (HP:0001927)2.25752413
63Bifid tongue (HP:0010297)2.25698769
64Increased density of long bones (HP:0006392)2.23499025
65Muscle fibrillation (HP:0010546)2.22938480
66Generalized aminoaciduria (HP:0002909)2.21924859
67Short nail (HP:0001799)2.20604046
68Abolished electroretinogram (ERG) (HP:0000550)2.20433542
69Occipital encephalocele (HP:0002085)2.19267579
70Microvesicular hepatic steatosis (HP:0001414)2.18459559
71Acute encephalopathy (HP:0006846)2.17253044
72Abnormality of the anterior horn cell (HP:0006802)2.15940080
73Degeneration of anterior horn cells (HP:0002398)2.15940080
74Thyroid carcinoma (HP:0002890)2.15796958
75Respiratory difficulties (HP:0002880)2.11377365
76Hepatocellular necrosis (HP:0001404)2.10798990
77Neuroendocrine neoplasm (HP:0100634)2.10634165
78Impaired vibration sensation in the lower limbs (HP:0002166)2.09551818
79Aplasia/Hypoplasia of the sternum (HP:0006714)2.08226500
80Morphological abnormality of the middle ear (HP:0008609)2.07912237
81Patent foramen ovale (HP:0001655)2.07841882
82Abnormality of dentin (HP:0010299)2.06953147
83Adrenal hypoplasia (HP:0000835)2.06198146
84Paralysis (HP:0003470)2.05793547
85Optic nerve hypoplasia (HP:0000609)2.05123021
86Abnormal auditory evoked potentials (HP:0006958)2.04896557
87Hypochromic microcytic anemia (HP:0004840)2.04037501
88Aplasia involving bones of the extremities (HP:0009825)2.03293445
89Aplasia involving bones of the upper limbs (HP:0009823)2.03293445
90Aplasia of the phalanges of the hand (HP:0009802)2.03293445
91Conjunctival telangiectasia (HP:0000524)2.03141472
92Papillary thyroid carcinoma (HP:0002895)2.02463630
93Exercise intolerance (HP:0003546)2.01444048
94Exercise-induced muscle cramps (HP:0003710)2.00460999
95Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98052333
96Vaginal atresia (HP:0000148)1.95649254
97Fibular hypoplasia (HP:0003038)1.95468179
98Preauricular pit (HP:0004467)1.94697026
99Periauricular skin pits (HP:0100277)1.94697026
100Abnormal umbilical cord blood vessels (HP:0011403)1.94543195
101Single umbilical artery (HP:0001195)1.94543195
102Abnormality of the fetal cardiovascular system (HP:0010948)1.94543195
103Hepatic necrosis (HP:0002605)1.93733571
104Genital tract atresia (HP:0001827)1.93646299
105Diastasis recti (HP:0001540)1.93160297
106Pancreatic cysts (HP:0001737)1.92678570
107Increased hepatocellular lipid droplets (HP:0006565)1.92251640
108Long clavicles (HP:0000890)1.92103686
109Abnormality of the fovea (HP:0000493)1.90942174
110Bruising susceptibility (HP:0000978)1.89791573
111Mesomelia (HP:0003027)1.89698892
112Degeneration of the lateral corticospinal tracts (HP:0002314)1.89673537
113Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.89673537
114Hyperalaninemia (HP:0003348)1.87444525
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87444525
116Abnormality of alanine metabolism (HP:0010916)1.87444525
117Dialeptic seizures (HP:0011146)1.87025013
118Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.86027398
119Abnormality of the vasculature of the conjunctiva (HP:0008054)1.85140095
120Limb dystonia (HP:0002451)1.84247567
121Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.83797679
122Shawl scrotum (HP:0000049)1.82614883
123Enlarged kidneys (HP:0000105)1.82452530
124Abnormality of the nasal septum (HP:0000419)1.81545179
125Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.81024040
126Decreased activity of mitochondrial respiratory chain (HP:0008972)1.81024040
127Recurrent abscess formation (HP:0002722)1.80486616
128Renal cortical cysts (HP:0000803)1.80327818
129Lip pit (HP:0100267)1.80275538
130Osteomalacia (HP:0002749)1.80165841
131Renal dysplasia (HP:0000110)1.78769101
132Abnormality of the phalanges of the 5th finger (HP:0004213)1.78012660
133Tongue fasciculations (HP:0001308)1.77919532
134Abnormality of macrophages (HP:0004311)1.77128266
135Agitation (HP:0000713)1.76847189
136Pancreatic islet-cell hyperplasia (HP:0004510)1.76809740
137Hepatosplenomegaly (HP:0001433)1.76582826
138Nausea (HP:0002018)1.75691889
139Abnormality of renal resorption (HP:0011038)1.75243868
140Hypomagnesemia (HP:0002917)1.74908203
141Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.74632962
142Eczematoid dermatitis (HP:0000976)1.73615250
143Primitive neuroectodermal tumor (HP:0030065)1.72343726
144Neuroblastic tumors (HP:0004376)1.72343726
145Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.72343726
146Neuroblastoma (HP:0003006)1.72343726
147Deep philtrum (HP:0002002)1.71535058
148Arthropathy (HP:0003040)1.71305578
149Aplasia/Hypoplasia of the fovea (HP:0008060)1.71039199
150Hypoplasia of the fovea (HP:0007750)1.71039199
151Tinnitus (HP:0000360)1.69626524
152Pulmonary artery stenosis (HP:0004415)1.68104414
153Broad toe (HP:0001837)1.67981745
154Encephalitis (HP:0002383)1.67879273
155Short middle phalanx of the 5th finger (HP:0004220)1.67696079
156Renal tubular dysfunction (HP:0000124)1.67430868
157Biliary tract neoplasm (HP:0100574)1.66561696
158Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.65824791
159Abnormality of the labia minora (HP:0012880)1.64784724
160Absent eyebrow (HP:0002223)1.64316467
161Lipid accumulation in hepatocytes (HP:0006561)1.64132854
162Abnormal lung lobation (HP:0002101)1.63857808
163Type I transferrin isoform profile (HP:0003642)1.63855723
164Distal lower limb muscle weakness (HP:0009053)1.61314253
165Delusions (HP:0000746)1.60827726
166Neoplasm of the adrenal cortex (HP:0100641)1.60778015
167Neoplasm of the peripheral nervous system (HP:0100007)1.60364036
168Dental crowding (HP:0000678)1.60255965
169Failure to thrive in infancy (HP:0001531)1.60222791
170Left ventricular hypertrophy (HP:0001712)1.60180371
171Broad alveolar ridges (HP:0000187)1.60162596
172Ventricular fibrillation (HP:0001663)1.59724481
173Growth hormone deficiency (HP:0000824)1.59127007
174Abnormal eating behavior (HP:0100738)1.58290285
175Poor suck (HP:0002033)1.57803890
176Focal motor seizures (HP:0011153)1.57117906
177Joint swelling (HP:0001386)1.56639823
178Absence seizures (HP:0002121)1.56473492
179Intention tremor (HP:0002080)1.56015360
180Recurrent bacterial skin infections (HP:0005406)1.55466738
181Generalized tonic-clonic seizures (HP:0002069)1.54915796
182Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.54504165
183Thyroid-stimulating hormone excess (HP:0002925)1.54185699
184Hyperinsulinemic hypoglycemia (HP:0000825)1.54155391
185Choroideremia (HP:0001139)1.52883751
186Retrobulbar optic neuritis (HP:0100654)1.52660309

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.13567992
2ZAK3.88348057
3ERBB33.40410289
4SIK33.26613038
5CASK3.25907095
6STK38L3.18661070
7AKT33.06257116
8BRSK22.87830908
9TRIM282.85135929
10TNIK2.79675152
11STK242.34142349
12NEK12.29911309
13SGK22.20564488
14PRKD32.16515628
15MYLK2.11150501
16PLK22.08849864
17PTK2B2.06152350
18PRPF4B2.04811712
19BMPR22.00881595
20BMX2.00705933
21OBSCN2.00475248
22CDK81.98883209
23TEC1.94283432
24TAOK31.84308627
25TSSK61.79891016
26WEE11.79539741
27BRSK11.78480882
28PLK31.75095751
29GRK61.74207621
30MKNK11.68753976
31LIMK11.68091064
32MAP3K121.64177153
33BCR1.56966021
34BUB11.52272015
35FGR1.51350770
36MKNK21.50957526
37DAPK21.48893944
38BTK1.47150300
39MINK11.46734307
40NEK91.44088407
41FRK1.42959141
42SYK1.37829493
43MAP2K71.36645348
44DYRK21.36507859
45TESK11.30879532
46SGK2231.30472215
47SGK4941.30472215
48MAP3K51.29507413
49MAPK131.28059035
50PIK3CG1.23145470
51CDK191.20486262
52SGK31.19620725
53BLK1.15461778
54YES11.15246045
55WNK31.14088900
56DYRK31.12217124
57CCNB11.03333921
58SRPK11.02779813
59FES1.01404713
60CSNK1G21.00797261
61CSNK1G31.00234266
62TAOK20.99962202
63MAP3K40.99517860
64VRK10.99373742
65CSF1R0.98096941
66STK30.96524019
67PINK10.95462032
68PIM20.95371271
69ZAP700.94826124
70PIK3CA0.94278594
71NEK60.93512048
72HCK0.92179580
73CSNK1G10.91429640
74MAP4K20.84458324
75BRAF0.84064196
76LATS20.83943414
77MARK30.82405642
78TRPM70.80052137
79LYN0.78224544
80NTRK30.77375555
81NLK0.77119166
82ADRBK20.76939820
83RPS6KB10.76842650
84ACVR1B0.76105615
85GRK70.75678922
86PNCK0.74822003
87PRKCE0.74655703
88PAK10.74529234
89CDC42BPA0.73363333
90DAPK30.72708237
91MAP2K40.72572198
92IRAK10.71918535
93CAMKK20.69625772
94DYRK1A0.69220060
95RPS6KA20.68277114
96PLK40.65390407
97ARAF0.64436160
98BMPR1B0.62557792
99PRKG10.61332243
100IRAK20.60500231
101FER0.59395040
102PRKCG0.58651565
103MAP3K30.58627458
104OXSR10.57316732
105CDK140.57264719
106MATK0.57052648
107PDK40.56471241
108PDK30.56471241
109MST40.56217945
110CSNK1A1L0.55494609
111CAMK2A0.55062261
112GRK50.54991756
113MAP3K60.54544786
114PLK10.53314311
115MAP2K30.52988182
116PASK0.52001779
117STK160.51556368
118EIF2AK10.50933276
119AURKA0.50539563
120JAK20.50328774
121CSK0.50125723
122EPHB10.49837729
123FGFR30.49386942
124PKN10.48702938
125EIF2AK30.48668340
126INSRR0.48356428
127RPS6KC10.47601597
128RPS6KL10.47601597
129GRK10.47597647
130TNK20.46845821
131EPHB20.46520889
132KSR10.46245569
133NME10.45938256
134CDK30.45922092
135TAOK10.43971921
136RAF10.43438325
137CSNK2A10.41802382
138MAP2K10.41646777
139ITK0.41438501
140ADRBK10.40922680
141UHMK10.39891236
142PRKD10.39548311
143FYN0.38295702
144MUSK0.37831112
145IRAK40.37732824
146TAF10.37691839
147ROCK10.37138192
148CHEK20.37086003
149ERBB40.35873343
150PAK30.35010296
151RPS6KA60.33039036
152EPHA20.32297743
153NUAK10.31787118
154CHUK0.31734650
155CDK180.31713245
156ILK0.31162348
157EIF2AK20.29828308
158PRKCH0.28336810
159TGFBR10.26804126
160PTK20.26622741
161PDK20.25883739
162DAPK10.25743651

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.55712328
2Platelet activation_Homo sapiens_hsa046113.52620969
3Oxidative phosphorylation_Homo sapiens_hsa001903.35135968
4Proteasome_Homo sapiens_hsa030503.15531985
5Collecting duct acid secretion_Homo sapiens_hsa049663.00857591
6Parkinsons disease_Homo sapiens_hsa050122.92219644
7Huntingtons disease_Homo sapiens_hsa050162.42156607
8Vibrio cholerae infection_Homo sapiens_hsa051102.39485683
9Morphine addiction_Homo sapiens_hsa050322.30149207
10RNA polymerase_Homo sapiens_hsa030202.24641146
11Synaptic vesicle cycle_Homo sapiens_hsa047212.22241586
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.21375808
13Protein export_Homo sapiens_hsa030602.05735516
14Nitrogen metabolism_Homo sapiens_hsa009102.03753535
15Fatty acid elongation_Homo sapiens_hsa000621.94207736
16Cardiac muscle contraction_Homo sapiens_hsa042601.91271349
17Phototransduction_Homo sapiens_hsa047441.82015470
18Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.79910936
19Cell cycle_Homo sapiens_hsa041101.78985526
20Gap junction_Homo sapiens_hsa045401.73821533
21Alzheimers disease_Homo sapiens_hsa050101.73205689
22Basal transcription factors_Homo sapiens_hsa030221.72689916
23Fructose and mannose metabolism_Homo sapiens_hsa000511.71793910
24Mismatch repair_Homo sapiens_hsa034301.67765022
25Galactose metabolism_Homo sapiens_hsa000521.51359179
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.44924514
272-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44622135
28Long-term depression_Homo sapiens_hsa047301.44541528
29Nucleotide excision repair_Homo sapiens_hsa034201.44192604
30RNA transport_Homo sapiens_hsa030131.42707098
31Glutamatergic synapse_Homo sapiens_hsa047241.42505714
32Chemokine signaling pathway_Homo sapiens_hsa040621.39247860
33Sulfur metabolism_Homo sapiens_hsa009201.37804725
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36998507
35Regulation of autophagy_Homo sapiens_hsa041401.34165356
36Base excision repair_Homo sapiens_hsa034101.32212359
37Spliceosome_Homo sapiens_hsa030401.28683810
38Alcoholism_Homo sapiens_hsa050341.28258731
39Shigellosis_Homo sapiens_hsa051311.21681532
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.20901092
41SNARE interactions in vesicular transport_Homo sapiens_hsa041301.19644442
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19101454
43Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18692243
44Hippo signaling pathway_Homo sapiens_hsa043901.17894973
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15037297
46Pyrimidine metabolism_Homo sapiens_hsa002401.14954505
47RNA degradation_Homo sapiens_hsa030181.14908554
48Olfactory transduction_Homo sapiens_hsa047401.13476755
49Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.11678286
50Hematopoietic cell lineage_Homo sapiens_hsa046401.11614518
51Vascular smooth muscle contraction_Homo sapiens_hsa042701.11029930
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10924548
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.09617001
54Melanoma_Homo sapiens_hsa052181.09488757
55Fanconi anemia pathway_Homo sapiens_hsa034601.06865774
56Purine metabolism_Homo sapiens_hsa002301.06602048
57Thyroid cancer_Homo sapiens_hsa052161.06539191
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04611460
59DNA replication_Homo sapiens_hsa030301.03229594
60Cholinergic synapse_Homo sapiens_hsa047251.02036192
61Phagosome_Homo sapiens_hsa041450.98052451
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97384787
63Homologous recombination_Homo sapiens_hsa034400.96723146
64Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95737018
65Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94895312
66TGF-beta signaling pathway_Homo sapiens_hsa043500.91738922
67Rheumatoid arthritis_Homo sapiens_hsa053230.90643882
68Endocytosis_Homo sapiens_hsa041440.90610295
69N-Glycan biosynthesis_Homo sapiens_hsa005100.88160515
70Gastric acid secretion_Homo sapiens_hsa049710.88102401
71Dilated cardiomyopathy_Homo sapiens_hsa054140.87517971
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85279994
73Basal cell carcinoma_Homo sapiens_hsa052170.83776990
74Circadian rhythm_Homo sapiens_hsa047100.83371005
75Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.83223926
76Oocyte meiosis_Homo sapiens_hsa041140.82091090
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.81956232
78Adherens junction_Homo sapiens_hsa045200.80479376
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.79078291
80Tight junction_Homo sapiens_hsa045300.78498272
81Endometrial cancer_Homo sapiens_hsa052130.75555755
82Carbon metabolism_Homo sapiens_hsa012000.75442719
83Pancreatic secretion_Homo sapiens_hsa049720.75284239
84Melanogenesis_Homo sapiens_hsa049160.75099010
85Rap1 signaling pathway_Homo sapiens_hsa040150.73037548
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72535625
87Renin secretion_Homo sapiens_hsa049240.72043000
88Oxytocin signaling pathway_Homo sapiens_hsa049210.70480514
89mRNA surveillance pathway_Homo sapiens_hsa030150.69414996
90Hedgehog signaling pathway_Homo sapiens_hsa043400.69007724
91Epstein-Barr virus infection_Homo sapiens_hsa051690.66393464
92Cocaine addiction_Homo sapiens_hsa050300.66391439
93Serotonergic synapse_Homo sapiens_hsa047260.65713809
94Insulin secretion_Homo sapiens_hsa049110.65380684
95Glutathione metabolism_Homo sapiens_hsa004800.65308884
96Wnt signaling pathway_Homo sapiens_hsa043100.63565268
97Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.63515500
98Legionellosis_Homo sapiens_hsa051340.62208015
99Taste transduction_Homo sapiens_hsa047420.61188639
100Arachidonic acid metabolism_Homo sapiens_hsa005900.60067958
101Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59341423
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.59201832
103Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58262387
104Dopaminergic synapse_Homo sapiens_hsa047280.57741138
105Salivary secretion_Homo sapiens_hsa049700.57471922
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57181814
107beta-Alanine metabolism_Homo sapiens_hsa004100.56294909
108Ras signaling pathway_Homo sapiens_hsa040140.56253956
109Circadian entrainment_Homo sapiens_hsa047130.54415676
110Salmonella infection_Homo sapiens_hsa051320.52545073
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.52539177
112Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52002464
113Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51644875
114One carbon pool by folate_Homo sapiens_hsa006700.51584605
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51222124
116Nicotine addiction_Homo sapiens_hsa050330.51126740
117cGMP-PKG signaling pathway_Homo sapiens_hsa040220.51012628
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49903646
119Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48260553
120Pyruvate metabolism_Homo sapiens_hsa006200.48125238
121Long-term potentiation_Homo sapiens_hsa047200.45094227
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.44867232
123p53 signaling pathway_Homo sapiens_hsa041150.44088695
124Type I diabetes mellitus_Homo sapiens_hsa049400.43889400
125HIF-1 signaling pathway_Homo sapiens_hsa040660.43429573
126Malaria_Homo sapiens_hsa051440.43224158
127GABAergic synapse_Homo sapiens_hsa047270.42988423
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42952775
129Metabolic pathways_Homo sapiens_hsa011000.42427750
130Steroid biosynthesis_Homo sapiens_hsa001000.42419231
131Starch and sucrose metabolism_Homo sapiens_hsa005000.42190302
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40375557
133Systemic lupus erythematosus_Homo sapiens_hsa053220.39891439
134Prostate cancer_Homo sapiens_hsa052150.39886107
135Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39798215
136Central carbon metabolism in cancer_Homo sapiens_hsa052300.39329799
137Glycerolipid metabolism_Homo sapiens_hsa005610.38810312
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.37515863
139Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37136490
140Non-homologous end-joining_Homo sapiens_hsa034500.36822042
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36178896
142Osteoclast differentiation_Homo sapiens_hsa043800.35746074
143Tuberculosis_Homo sapiens_hsa051520.35381209
144Amphetamine addiction_Homo sapiens_hsa050310.35214176
145Peroxisome_Homo sapiens_hsa041460.34859185
146Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.34395293
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.33988761
148Biosynthesis of amino acids_Homo sapiens_hsa012300.33124192
149cAMP signaling pathway_Homo sapiens_hsa040240.32001296
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31911764
151Calcium signaling pathway_Homo sapiens_hsa040200.30605928
152Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.27235561

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