TMEM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a type II transmembrane protein that is thought to have glycosyltransferase function. Mutations in this gene result in cobblestone lissencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.27880619
2L-methionine biosynthetic process from methylthioadenosine (GO:0019509)5.18218785
3signal peptide processing (GO:0006465)4.89933497
4proteasome assembly (GO:0043248)4.85537893
5indolalkylamine metabolic process (GO:0006586)4.24539734
6amino acid salvage (GO:0043102)4.07094090
7L-methionine salvage (GO:0071267)4.07094090
8L-methionine biosynthetic process (GO:0071265)4.07094090
9protein-cofactor linkage (GO:0018065)3.94585019
10cellular ketone body metabolic process (GO:0046950)3.91158929
11negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.87907492
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.82227423
13fucose catabolic process (GO:0019317)3.79135011
14L-fucose metabolic process (GO:0042354)3.79135011
15L-fucose catabolic process (GO:0042355)3.79135011
16cotranslational protein targeting to membrane (GO:0006613)3.78061270
17protein targeting to ER (GO:0045047)3.76522962
18protein localization to endoplasmic reticulum (GO:0070972)3.67913494
19ribosome assembly (GO:0042255)3.67460377
20establishment of protein localization to endoplasmic reticulum (GO:0072599)3.66550036
21termination of RNA polymerase III transcription (GO:0006386)3.66203146
22transcription elongation from RNA polymerase III promoter (GO:0006385)3.66203146
23chaperone-mediated protein transport (GO:0072321)3.65009005
24behavioral response to nicotine (GO:0035095)3.64773247
25ketone body metabolic process (GO:1902224)3.63886939
26preassembly of GPI anchor in ER membrane (GO:0016254)3.54537499
27pteridine-containing compound biosynthetic process (GO:0042559)3.53780913
28protein neddylation (GO:0045116)3.51251789
29mitochondrial respiratory chain complex assembly (GO:0033108)3.50066359
30detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.45903118
31antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.40543947
32respiratory chain complex IV assembly (GO:0008535)3.40295129
33mannosylation (GO:0097502)3.38035209
34translation (GO:0006412)3.37693390
35maturation of 5.8S rRNA (GO:0000460)3.36580673
36protein targeting to mitochondrion (GO:0006626)3.35598983
37formation of translation preinitiation complex (GO:0001731)3.35110645
38regulation of metalloenzyme activity (GO:0048552)3.32409048
39indolalkylamine catabolic process (GO:0046218)3.30194650
40tryptophan catabolic process (GO:0006569)3.30194650
41indole-containing compound catabolic process (GO:0042436)3.30194650
42establishment of protein localization to mitochondrion (GO:0072655)3.28497074
43ribosomal small subunit assembly (GO:0000028)3.26184845
44translational termination (GO:0006415)3.26117538
45neural tube formation (GO:0001841)3.23504945
46mitochondrial respiratory chain complex I assembly (GO:0032981)3.21657580
47NADH dehydrogenase complex assembly (GO:0010257)3.21657580
48mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21657580
49viral transcription (GO:0019083)3.20516408
50regulation of mitochondrial translation (GO:0070129)3.17890835
51ribosomal small subunit biogenesis (GO:0042274)3.17167606
52GTP biosynthetic process (GO:0006183)3.17004905
53DNA double-strand break processing (GO:0000729)3.15851179
54protein K11-linked deubiquitination (GO:0035871)3.15077186
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.13221872
56protein localization to mitochondrion (GO:0070585)3.10890662
57methionine biosynthetic process (GO:0009086)3.09835170
58pseudouridine synthesis (GO:0001522)3.09504629
59axoneme assembly (GO:0035082)3.08541809
60rRNA modification (GO:0000154)3.08021596
61platelet dense granule organization (GO:0060155)3.06323069
62translational elongation (GO:0006414)3.05706965
63regulation of glucokinase activity (GO:0033131)3.00961178
64regulation of hexokinase activity (GO:1903299)3.00961178
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.99985645
66maturation of SSU-rRNA (GO:0030490)2.99465793
67protein deneddylation (GO:0000338)2.98983244
68peptidyl-histidine modification (GO:0018202)2.98893958
69protein maturation by protein folding (GO:0022417)2.98693874
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.97317679
71response to pheromone (GO:0019236)2.95938315
72reciprocal DNA recombination (GO:0035825)2.94952650
73reciprocal meiotic recombination (GO:0007131)2.94952650
74ribosomal large subunit biogenesis (GO:0042273)2.94949404
75nucleobase-containing small molecule interconversion (GO:0015949)2.94460428
76kynurenine metabolic process (GO:0070189)2.94444359
77water-soluble vitamin biosynthetic process (GO:0042364)2.93981349
78translational initiation (GO:0006413)2.93936171
79negative regulation of ligase activity (GO:0051352)2.92930097
80negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92930097
81piRNA metabolic process (GO:0034587)2.91737794
827-methylguanosine mRNA capping (GO:0006370)2.91665724
83intraciliary transport (GO:0042073)2.91456978
84cytochrome complex assembly (GO:0017004)2.91270043
85tryptophan metabolic process (GO:0006568)2.90627900
86antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.90370427
87rRNA methylation (GO:0031167)2.89734269
88intracellular protein transmembrane import (GO:0044743)2.89345589
89guanosine-containing compound biosynthetic process (GO:1901070)2.89343679
90regulation of cellular amino acid metabolic process (GO:0006521)2.89228291
91protein complex biogenesis (GO:0070271)2.89032354
92indole-containing compound metabolic process (GO:0042430)2.88769308
93C-terminal protein lipidation (GO:0006501)2.88650035
94oxidative demethylation (GO:0070989)2.87097190
95synapsis (GO:0007129)2.87005253
96epithelial cilium movement (GO:0003351)2.86483180
97UTP biosynthetic process (GO:0006228)2.86108009
98tRNA processing (GO:0008033)2.85405470
99positive regulation of prostaglandin secretion (GO:0032308)2.85371945
100double-strand break repair via homologous recombination (GO:0000724)2.84144179
101regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83385903
102recombinational repair (GO:0000725)2.82904114
103adult feeding behavior (GO:0008343)2.81928464
104epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.81586222
105protein localization to cilium (GO:0061512)2.80970196
106RNA capping (GO:0036260)2.80920972
1077-methylguanosine RNA capping (GO:0009452)2.80920972
108GPI anchor metabolic process (GO:0006505)2.80442626
109regulation of integrin-mediated signaling pathway (GO:2001044)2.80188230
110transcription from RNA polymerase I promoter (GO:0006360)2.78400253
111mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.78122487
112polyamine metabolic process (GO:0006595)2.78066029
113C-terminal protein amino acid modification (GO:0018410)2.77853869
114collagen fibril organization (GO:0030199)2.77315668
115cilium morphogenesis (GO:0060271)2.76584143
116nonmotile primary cilium assembly (GO:0035058)2.76447468
117ribonucleoprotein complex biogenesis (GO:0022613)2.75060090
118protein peptidyl-prolyl isomerization (GO:0000413)2.74119986
119rRNA processing (GO:0006364)2.72802451
120UTP metabolic process (GO:0046051)2.72421720
121protein targeting to membrane (GO:0006612)2.72071405
122mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71882006
123DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71540090
124ubiquinone biosynthetic process (GO:0006744)2.71375024
125reflex (GO:0060004)2.71340438
126branched-chain amino acid catabolic process (GO:0009083)2.70822742
127GDP-mannose metabolic process (GO:0019673)2.70793006
128folic acid-containing compound biosynthetic process (GO:0009396)2.68864370
129purine-containing compound salvage (GO:0043101)2.68839247
130cilium organization (GO:0044782)2.68105223
131regulation of cilium movement (GO:0003352)2.67913006
132cullin deneddylation (GO:0010388)2.67783565
133signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.67436667
134intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.67436667
135anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.67422346
136male meiosis I (GO:0007141)2.66126703
137signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.65876665
138signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.65876665
139signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.65876665
140peptidyl-proline modification (GO:0018208)2.65345862
141termination of RNA polymerase I transcription (GO:0006363)2.64974926
142adaptation of signaling pathway (GO:0023058)2.64576004
143CTP metabolic process (GO:0046036)2.64554279
144CTP biosynthetic process (GO:0006241)2.64554279
145aspartate family amino acid biosynthetic process (GO:0009067)2.63269016
146cellular component biogenesis (GO:0044085)2.62515420
147replication fork processing (GO:0031297)2.62208090
148positive regulation of ligase activity (GO:0051351)2.62190772
149nucleotide transmembrane transport (GO:1901679)2.60369507
150wound healing, spreading of cells (GO:0044319)2.60268728
151ribosome biogenesis (GO:0042254)2.60227451
152cilium assembly (GO:0042384)2.60146076
153behavioral response to ethanol (GO:0048149)2.60107399
154regulation of nuclear cell cycle DNA replication (GO:0033262)2.58666020
155anterograde synaptic vesicle transport (GO:0048490)2.57990949
156mesenchymal-epithelial cell signaling (GO:0060638)2.57453060
157protein retention in ER lumen (GO:0006621)2.56882247
158transcription-coupled nucleotide-excision repair (GO:0006283)2.56663690
159ATP synthesis coupled proton transport (GO:0015986)2.56479269
160energy coupled proton transport, down electrochemical gradient (GO:0015985)2.56479269
161negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.56327364
162auditory receptor cell stereocilium organization (GO:0060088)2.56259881
163ubiquinone metabolic process (GO:0006743)2.54669422
164mitochondrial RNA metabolic process (GO:0000959)2.54095992
165male meiosis (GO:0007140)2.53929800
166establishment of protein localization to mitochondrial membrane (GO:0090151)2.51587692
167somite rostral/caudal axis specification (GO:0032525)2.51363534
168GPI anchor biosynthetic process (GO:0006506)2.50720664
169cornea development in camera-type eye (GO:0061303)2.49884596
170rRNA catabolic process (GO:0016075)2.48607972
171regulation of rhodopsin mediated signaling pathway (GO:0022400)2.48248022
172tachykinin receptor signaling pathway (GO:0007217)2.48127815
173multicellular organism reproduction (GO:0032504)2.45800036
174detection of light stimulus involved in sensory perception (GO:0050962)2.44768102
175detection of light stimulus involved in visual perception (GO:0050908)2.44768102
176DNA methylation involved in gamete generation (GO:0043046)2.44710902
177centriole replication (GO:0007099)2.43024398
178dopamine transport (GO:0015872)2.43010621
179meiotic chromosome segregation (GO:0045132)2.42999368
180cilium movement (GO:0003341)2.42925980
181adenosine metabolic process (GO:0046085)2.42676822

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GABP_17652178_ChIP-ChIP_JURKAT_Human4.68696551
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57234400
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.12612840
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.86494231
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.63905339
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.53930891
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.53186708
8ZNF274_21170338_ChIP-Seq_K562_Hela3.45070967
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.43957713
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.36494178
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.36211722
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.86641345
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.80380397
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78667668
15* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.69497709
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.67599731
17ELK1_19687146_ChIP-ChIP_HELA_Human2.67557166
18* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62390182
19GBX2_23144817_ChIP-Seq_PC3_Human2.60753755
20VDR_23849224_ChIP-Seq_CD4+_Human2.58107765
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.57126780
22VDR_22108803_ChIP-Seq_LS180_Human2.53877752
23* DCP1A_22483619_ChIP-Seq_HELA_Human2.52675474
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.44924601
25SRF_21415370_ChIP-Seq_HL-1_Mouse2.44786487
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38583539
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.35551722
28* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35492813
29ELK1_22589737_ChIP-Seq_MCF10A_Human2.32577811
30FLI1_27457419_Chip-Seq_LIVER_Mouse2.32558829
31IGF1R_20145208_ChIP-Seq_DFB_Human2.31148246
32FUS_26573619_Chip-Seq_HEK293_Human2.28815896
33TAF15_26573619_Chip-Seq_HEK293_Human2.28236293
34MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.25880790
35ELF1_17652178_ChIP-ChIP_JURKAT_Human2.21447458
36EWS_26573619_Chip-Seq_HEK293_Human2.17442202
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.15805639
38ERG_20887958_ChIP-Seq_HPC-7_Mouse2.14121353
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09386946
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08514480
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06698392
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.05564600
43GABP_19822575_ChIP-Seq_HepG2_Human2.04009106
44* CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02303647
45ER_23166858_ChIP-Seq_MCF-7_Human2.02231068
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.01337290
47P300_19829295_ChIP-Seq_ESCs_Human1.94636130
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.93395411
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92435833
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.88725967
51SALL1_21062744_ChIP-ChIP_HESCs_Human1.88271691
52XRN2_22483619_ChIP-Seq_HELA_Human1.87212732
53RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86619289
54RARG_19884340_ChIP-ChIP_MEFs_Mouse1.86164400
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84775135
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82162715
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.81143506
58MYC_18940864_ChIP-ChIP_HL60_Human1.79403523
59HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76825168
60FOXP3_21729870_ChIP-Seq_TREG_Human1.76605930
61PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.74192519
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73689609
63TP53_22573176_ChIP-Seq_HFKS_Human1.69767302
64E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.69655261
65TFEB_21752829_ChIP-Seq_HELA_Human1.67489018
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65553048
67TTF2_22483619_ChIP-Seq_HELA_Human1.63514289
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61833832
69TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59775617
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.59560359
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.57453281
72AR_21909140_ChIP-Seq_LNCAP_Human1.56652579
73GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54347131
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.51303182
75IRF1_19129219_ChIP-ChIP_H3396_Human1.51064807
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.50260812
77EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.48956468
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.48219157
79SMAD4_21799915_ChIP-Seq_A2780_Human1.41962659
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41791356
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.38399254
82CBP_20019798_ChIP-Seq_JUKART_Human1.37986112
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37986112
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.37448273
85UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36450547
86HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.34953115
87FOXA1_27270436_Chip-Seq_PROSTATE_Human1.34603472
88FOXA1_25329375_ChIP-Seq_VCAP_Human1.34603472
89AR_25329375_ChIP-Seq_VCAP_Human1.31436707
90STAT3_23295773_ChIP-Seq_U87_Human1.30324353
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.26804724
92MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24861886
93MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24070770
94EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23692948
95WT1_19549856_ChIP-ChIP_CCG9911_Human1.23329213
96SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21894521
97HTT_18923047_ChIP-ChIP_STHdh_Human1.21588938
98SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.21526851
99NR3C1_21868756_ChIP-Seq_MCF10A_Human1.21162153
100SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.21019651
101* TCF4_23295773_ChIP-Seq_U87_Human1.20922663
102SOX2_19829295_ChIP-Seq_ESCs_Human1.20306032
103NANOG_19829295_ChIP-Seq_ESCs_Human1.20306032
104KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20190652
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.20089702
106TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.19544203
107CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.19141360
108FOXA1_21572438_ChIP-Seq_LNCaP_Human1.19093240
109E2F7_22180533_ChIP-Seq_HELA_Human1.19083736
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.18830104
111SPI1_23547873_ChIP-Seq_NB4_Human1.17195965
112TBX5_21415370_ChIP-Seq_HL-1_Mouse1.16972068
113EGR1_23403033_ChIP-Seq_LIVER_Mouse1.15632697
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15199640
115* SOX17_20123909_ChIP-Seq_XEN_Mouse1.14571450
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14267735
117RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.14033505
118AR_20517297_ChIP-Seq_VCAP_Human1.14021682
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13318439
120* TCF4_22108803_ChIP-Seq_LS180_Human1.12772262
121BCAT_22108803_ChIP-Seq_LS180_Human1.12695312
122CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12449571
123BMI1_23680149_ChIP-Seq_NPCS_Mouse1.11984237
124NOTCH1_21737748_ChIP-Seq_TLL_Human1.11960483
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11258184
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10294331
127* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09943678
128TOP2B_26459242_ChIP-Seq_MCF-7_Human1.09915097
129HOXB7_26014856_ChIP-Seq_BT474_Human1.09244504
130* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.09180112
131OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09072466
132CRX_20693478_ChIP-Seq_RETINA_Mouse1.08664658
133BP1_19119308_ChIP-ChIP_Hs578T_Human1.08649911
134NANOG_18555785_Chip-Seq_ESCs_Mouse1.08606485
135PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08585077
136CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.08455045
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07294977
138BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.06797033
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05835868
140NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05236678
141GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04970480
142P53_22387025_ChIP-Seq_ESCs_Mouse1.04328505
143NCOR_22424771_ChIP-Seq_293T_Human1.04010097
144NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03868923
145NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03868923
146HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03601196
147TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.03255688
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01753912
149STAT3_18555785_Chip-Seq_ESCs_Mouse1.01640348
150CDX2_22108803_ChIP-Seq_LS180_Human1.00941955
151EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00187791
152RUNX2_22187159_ChIP-Seq_PCA_Human0.99779642
153CLOCK_20551151_ChIP-Seq_293T_Human0.99405847
154E2F4_17652178_ChIP-ChIP_JURKAT_Human0.99119227
155SMAD3_21741376_ChIP-Seq_EPCs_Human0.99039293
156FLI1_21867929_ChIP-Seq_TH2_Mouse0.98599985
157PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.98238869
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98157236
159SOX2_20726797_ChIP-Seq_SW620_Human0.97795541
160E2F1_18555785_Chip-Seq_ESCs_Mouse0.97533914
161EOMES_21245162_ChIP-Seq_HESCs_Human0.97019321
162MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.96958775
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95688024
164SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94444583
165ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.92559810
166NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.89707852
167ELF5_23300383_ChIP-Seq_T47D_Human0.87623523
168STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87435260
169MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87025368
170SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86468275
171PADI4_21655091_ChIP-ChIP_MCF-7_Human0.86058983
172GATA4_21415370_ChIP-Seq_HL-1_Mouse0.85459978
173POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85455423
174* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85196358
175CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.84794879
176SALL4_18804426_ChIP-ChIP_XEN_Mouse0.84213205
177FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.83967676
178POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.83270187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen6.61214927
2MP0005503_abnormal_tendon_morphology3.72677887
3MP0002837_dystrophic_cardiac_calcinosis3.18180289
4MP0002102_abnormal_ear_morphology2.87122909
5MP0006054_spinal_hemorrhage2.70958399
6MP0003136_yellow_coat_color2.61183707
7MP0003186_abnormal_redox_activity2.57609075
8MP0004272_abnormal_basement_membrane2.56742773
9MP0005275_abnormal_skin_tensile2.47113106
10MP0009379_abnormal_foot_pigmentation2.41615077
11MP0003806_abnormal_nucleotide_metabolis2.40808637
12MP0000569_abnormal_digit_pigmentation2.30452642
13MP0005551_abnormal_eye_electrophysiolog2.25021639
14MP0002234_abnormal_pharynx_morphology2.22125203
15MP0005645_abnormal_hypothalamus_physiol2.19772539
16MP0005623_abnormal_meninges_morphology2.15357566
17MP0008875_abnormal_xenobiotic_pharmacok2.12401466
18MP0002876_abnormal_thyroid_physiology2.06046793
19MP0003279_aneurysm2.05349789
20MP0006072_abnormal_retinal_apoptosis2.04409692
21MP0009697_abnormal_copulation1.94888649
22MP0008058_abnormal_DNA_repair1.93552796
23MP0010386_abnormal_urinary_bladder1.93359853
24MP0003950_abnormal_plasma_membrane1.92142452
25MP0003123_paternal_imprinting1.91079159
26MP0005646_abnormal_pituitary_gland1.90446938
27MP0008877_abnormal_DNA_methylation1.90147825
28MP0009250_abnormal_appendicular_skeleto1.89839925
29MP0005075_abnormal_melanosome_morpholog1.86468214
30MP0001542_abnormal_bone_strength1.86388401
31MP0008932_abnormal_embryonic_tissue1.85387486
32MP0002295_abnormal_pulmonary_circulatio1.84554310
33MP0005508_abnormal_skeleton_morphology1.82951199
34MP0000372_irregular_coat_pigmentation1.81833098
35MP0005379_endocrine/exocrine_gland_phen1.79822332
36MP0002163_abnormal_gland_morphology1.74151373
37MP0008872_abnormal_physiological_respon1.69788959
38MP0001984_abnormal_olfaction1.66827515
39MP0004957_abnormal_blastocyst_morpholog1.63964239
40MP0003718_maternal_effect1.62775525
41MP0005253_abnormal_eye_physiology1.61069612
42MP0005174_abnormal_tail_pigmentation1.60389323
43MP0009780_abnormal_chondrocyte_physiolo1.60319801
44MP0003646_muscle_fatigue1.59689619
45MP0001501_abnormal_sleep_pattern1.58514456
46MP0010352_gastrointestinal_tract_polyps1.57370182
47MP0001529_abnormal_vocalization1.57237380
48MP0003724_increased_susceptibility_to1.54906213
49MP0002160_abnormal_reproductive_system1.54556724
50MP0006292_abnormal_olfactory_placode1.53879841
51MP0005023_abnormal_wound_healing1.53410471
52MP0000631_abnormal_neuroendocrine_gland1.53168817
53MP0005171_absent_coat_pigmentation1.51934471
54MP0000013_abnormal_adipose_tissue1.50150200
55MP0009046_muscle_twitch1.49959626
56MP0000427_abnormal_hair_cycle1.47474188
57MP0001958_emphysema1.47436329
58MP0009384_cardiac_valve_regurgitation1.47050857
59MP0005390_skeleton_phenotype1.46357793
60MP0000747_muscle_weakness1.45861640
61MP0003693_abnormal_embryo_hatching1.45632456
62MP0004142_abnormal_muscle_tone1.43642770
63MP0002095_abnormal_skin_pigmentation1.41869037
64MP0001188_hyperpigmentation1.41015286
65MP0002736_abnormal_nociception_after1.39308962
66MP0003011_delayed_dark_adaptation1.39013147
67MP0001968_abnormal_touch/_nociception1.38264730
68MP0003787_abnormal_imprinting1.38096514
69MP0002933_joint_inflammation1.35473000
70MP0000681_abnormal_thyroid_gland1.34658824
71MP0004147_increased_porphyrin_level1.34409297
72MP0000920_abnormal_myelination1.33986300
73MP0000383_abnormal_hair_follicle1.33061063
74MP0001533_abnormal_skeleton_physiology1.31512883
75MP0000163_abnormal_cartilage_morphology1.29628190
76MP0004145_abnormal_muscle_electrophysio1.28714525
77MP0002693_abnormal_pancreas_physiology1.27984399
78MP0006035_abnormal_mitochondrial_morpho1.27396970
79MP0000015_abnormal_ear_pigmentation1.27382886
80MP0000750_abnormal_muscle_regeneration1.27037151
81MP0005410_abnormal_fertilization1.26121077
82MP0002282_abnormal_trachea_morphology1.25173726
83MP0005058_abnormal_lysosome_morphology1.25156504
84MP0000343_altered_response_to1.23931194
85MP0010368_abnormal_lymphatic_system1.23115900
86MP0002938_white_spotting1.22118499
87MP0004134_abnormal_chest_morphology1.21975116
88MP0006276_abnormal_autonomic_nervous1.21077919
89MP0001905_abnormal_dopamine_level1.20701820
90MP0000049_abnormal_middle_ear1.19724135
91MP0002909_abnormal_adrenal_gland1.16361834
92MP0008007_abnormal_cellular_replicative1.16213525
93MP0005367_renal/urinary_system_phenotyp1.15469749
94MP0000516_abnormal_urinary_system1.15469749
95MP0000858_altered_metastatic_potential1.15097688
96MP0002396_abnormal_hematopoietic_system1.14868157
97MP0002272_abnormal_nervous_system1.13993550
98MP0010094_abnormal_chromosome_stability1.13143511
99MP0000538_abnormal_urinary_bladder1.12586863
100MP0002089_abnormal_postnatal_growth/wei1.12216283
101MP0004215_abnormal_myocardial_fiber1.12093270
102MP0002113_abnormal_skeleton_development1.10318149
103MP0009745_abnormal_behavioral_response1.10157507
104MP0002877_abnormal_melanocyte_morpholog1.09912735
105MP0003786_premature_aging1.09908499
106MP0005389_reproductive_system_phenotype1.09624866
107MP0000647_abnormal_sebaceous_gland1.08704047
108MP0002928_abnormal_bile_duct1.07443864
109MP0005187_abnormal_penis_morphology1.06688560
110MP0002177_abnormal_outer_ear1.06519530
111MP0008775_abnormal_heart_ventricle1.05959800
112MP0000358_abnormal_cell_content/1.05249726
113MP0005408_hypopigmentation1.05249439
114MP0003195_calcinosis1.05111424
115MP0001764_abnormal_homeostasis1.04618738
116MP0005332_abnormal_amino_acid1.04282274
117MP0003283_abnormal_digestive_organ1.04116032
118MP0004043_abnormal_pH_regulation1.02944579
119MP0003795_abnormal_bone_structure1.01962950
120MP0009333_abnormal_splenocyte_physiolog1.01581076
121MP0004133_heterotaxia1.00162808
122MP0000749_muscle_degeneration0.99977539
123MP0008961_abnormal_basal_metabolism0.99705783
124MP0008789_abnormal_olfactory_epithelium0.99693253
125MP0001929_abnormal_gametogenesis0.98949590
126MP0005595_abnormal_vascular_smooth0.97903594
127MP0003091_abnormal_cell_migration0.97100533
128MP0001944_abnormal_pancreas_morphology0.96857658
129MP0005386_behavior/neurological_phenoty0.95375395
130MP0004924_abnormal_behavior0.95375395
131MP0003937_abnormal_limbs/digits/tail_de0.95370489
132MP0001661_extended_life_span0.95177920
133MP0002998_abnormal_bone_remodeling0.94834896
134MP0001324_abnormal_eye_pigmentation0.94637692
135MP0001299_abnormal_eye_distance/0.94585262
136MP0001919_abnormal_reproductive_system0.94411161
137MP0002896_abnormal_bone_mineralization0.92999486
138MP0001243_abnormal_dermal_layer0.92686067
139MP0010678_abnormal_skin_adnexa0.92220022
140MP0003698_abnormal_male_reproductive0.91976102
141MP0005164_abnormal_response_to0.91444006
142MP0003252_abnormal_bile_duct0.91251486
143MP0004885_abnormal_endolymph0.90669452
144MP0000733_abnormal_muscle_development0.90271954
145MP0003890_abnormal_embryonic-extraembry0.89613174
146MP0002115_abnormal_skeleton_extremities0.87263249
147MP0002638_abnormal_pupillary_reflex0.86642185
148MP0000678_abnormal_parathyroid_gland0.86012989
149MP0002210_abnormal_sex_determination0.85836845
150MP0000465_gastrointestinal_hemorrhage0.85522349
151MP0003705_abnormal_hypodermis_morpholog0.85394980
152MP0002557_abnormal_social/conspecific_i0.85343908
153MP0005448_abnormal_energy_balance0.84752181
154MP0001915_intracranial_hemorrhage0.83407680
155MP0000371_diluted_coat_color0.83184683
156MP0002060_abnormal_skin_morphology0.82744487
157MP0002653_abnormal_ependyma_morphology0.82402177
158MP0000490_abnormal_crypts_of0.82396664
159MP0010030_abnormal_orbit_morphology0.80935297
160MP0005636_abnormal_mineral_homeostasis0.80192577
161MP0002090_abnormal_vision0.78415959
162MP0002229_neurodegeneration0.77714288
163MP0000762_abnormal_tongue_morphology0.77179866
164MP0006036_abnormal_mitochondrial_physio0.76715548
165MP0008995_early_reproductive_senescence0.76156553
166MP0002108_abnormal_muscle_morphology0.75723877
167MP0001502_abnormal_circadian_rhythm0.74820924
168MP0005220_abnormal_exocrine_pancreas0.74366663
169MP0000759_abnormal_skeletal_muscle0.73979934
170MP0003077_abnormal_cell_cycle0.72988434
171MP0001348_abnormal_lacrimal_gland0.71970279
172MP0005197_abnormal_uvea_morphology0.71779577
173MP0005193_abnormal_anterior_eye0.71588174
174MP0005395_other_phenotype0.70700641
175MP0005084_abnormal_gallbladder_morpholo0.69491631
176MP0008260_abnormal_autophagy0.65690558
177MP0003566_abnormal_cell_adhesion0.65506527
178MP0003656_abnormal_erythrocyte_physiolo0.64772002
179MP0005165_increased_susceptibility_to0.63691751
180MP0005257_abnormal_intraocular_pressure0.63378025
181MP0001175_abnormal_lung_morphology0.61795601
182MP0000462_abnormal_digestive_system0.60492776
183MP0005397_hematopoietic_system_phenotyp0.59946894
184MP0001545_abnormal_hematopoietic_system0.59946894
185MP0002269_muscular_atrophy0.59506815

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.06500973
2Protrusio acetabuli (HP:0003179)4.60749922
3Pancreatic cysts (HP:0001737)4.28442170
4Abnormality of dentin (HP:0010299)4.15741803
5Pancreatic fibrosis (HP:0100732)3.98370251
6Molar tooth sign on MRI (HP:0002419)3.94544157
7Abnormality of midbrain morphology (HP:0002418)3.94544157
8Birth length less than 3rd percentile (HP:0003561)3.76292261
9True hermaphroditism (HP:0010459)3.74874601
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.73553490
11Abnormality of alanine metabolism (HP:0010916)3.73553490
12Hyperalaninemia (HP:0003348)3.73553490
13Vertebral compression fractures (HP:0002953)3.54860499
14Renal Fanconi syndrome (HP:0001994)3.39275549
15Poor head control (HP:0002421)3.38134334
16Nephronophthisis (HP:0000090)3.23685262
17Aplastic anemia (HP:0001915)3.23558027
183-Methylglutaconic aciduria (HP:0003535)3.17225095
19Cerebral hypomyelination (HP:0006808)3.14430783
20Congenital stationary night blindness (HP:0007642)3.12924210
21Medial flaring of the eyebrow (HP:0010747)3.12171653
22Beaking of vertebral bodies (HP:0004568)3.11272692
23* Retinal dysplasia (HP:0007973)3.03805648
24Decreased activity of mitochondrial respiratory chain (HP:0008972)3.03059272
25Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.03059272
26* Type II lissencephaly (HP:0007260)3.01731039
27Soft skin (HP:0000977)2.92612122
28Abnormality of the renal cortex (HP:0011035)2.92490144
29Cervical subluxation (HP:0003308)2.89966237
30Chronic hepatic failure (HP:0100626)2.88276487
31Postnatal microcephaly (HP:0005484)2.81721835
32Hepatocellular necrosis (HP:0001404)2.80373335
33Increased hepatocellular lipid droplets (HP:0006565)2.79440993
34Male pseudohermaphroditism (HP:0000037)2.73459413
35Attenuation of retinal blood vessels (HP:0007843)2.69422535
36Acute necrotizing encephalopathy (HP:0006965)2.69176106
37Abnormality of the renal medulla (HP:0100957)2.68608238
38Peritonitis (HP:0002586)2.67209044
39Metaphyseal dysplasia (HP:0100255)2.66754982
40Ketoacidosis (HP:0001993)2.65355572
41Hypothermia (HP:0002045)2.64423807
42Mitochondrial inheritance (HP:0001427)2.63627561
43Methylmalonic acidemia (HP:0002912)2.59127973
44Aplasia/Hypoplasia of the tibia (HP:0005772)2.58728603
45Biconcave vertebral bodies (HP:0004586)2.56294658
46Aplasia/Hypoplasia of the tongue (HP:0010295)2.54512554
47Ankle contracture (HP:0006466)2.54167037
48Decreased central vision (HP:0007663)2.51991628
49Large for gestational age (HP:0001520)2.49947577
50Abnormal rod and cone electroretinograms (HP:0008323)2.49699187
51Congenital primary aphakia (HP:0007707)2.48872542
52Hepatic necrosis (HP:0002605)2.48619621
53Lipid accumulation in hepatocytes (HP:0006561)2.47413744
54Cystic liver disease (HP:0006706)2.46403115
55Irregular epiphyses (HP:0010582)2.44365141
56Wormian bones (HP:0002645)2.43111453
57Tubular atrophy (HP:0000092)2.42193156
58Type I transferrin isoform profile (HP:0003642)2.41461833
59Gait imbalance (HP:0002141)2.40795575
60Increased CSF lactate (HP:0002490)2.39235598
61Abnormal mitochondria in muscle tissue (HP:0008316)2.38271544
62Renal cortical cysts (HP:0000803)2.36869355
63Progressive inability to walk (HP:0002505)2.36343455
64Nephrogenic diabetes insipidus (HP:0009806)2.35322267
65Abolished electroretinogram (ERG) (HP:0000550)2.34914275
66Aortic dissection (HP:0002647)2.34136015
67Progressive macrocephaly (HP:0004481)2.32653613
68Abnormality of the phalanges of the 2nd finger (HP:0009541)2.32586861
69Abnormal protein glycosylation (HP:0012346)2.31677238
70Abnormal glycosylation (HP:0012345)2.31677238
71Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31677238
72Abnormal protein N-linked glycosylation (HP:0012347)2.31677238
73Abnormality of glycolysis (HP:0004366)2.30685224
74Increased serum pyruvate (HP:0003542)2.30685224
75Epiphyseal dysplasia (HP:0002656)2.30038810
76Rough bone trabeculation (HP:0100670)2.29290428
77Sclerocornea (HP:0000647)2.26520984
78Autoamputation (HP:0001218)2.26408327
79Furrowed tongue (HP:0000221)2.26290387
80Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.24433697
81Concave nail (HP:0001598)2.19643763
82Slender long bone (HP:0003100)2.19146624
83Increased serum lactate (HP:0002151)2.17068345
84Short tibia (HP:0005736)2.16830686
85Methylmalonic aciduria (HP:0012120)2.16244787
86Hypoplasia of the fovea (HP:0007750)2.14995635
87Aplasia/Hypoplasia of the fovea (HP:0008060)2.14995635
88Exertional dyspnea (HP:0002875)2.14195719
89Increased intramyocellular lipid droplets (HP:0012240)2.11159144
90Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.11043372
91Aplasia/Hypoplasia of the uvula (HP:0010293)2.10932874
92Tracheomalacia (HP:0002779)2.10911642
93Aplasia/Hypoplasia of the sacrum (HP:0008517)2.10625674
94Deformed tarsal bones (HP:0008119)2.10165843
95Acute encephalopathy (HP:0006846)2.09782107
96Buphthalmos (HP:0000557)2.09723247
97Increased corneal curvature (HP:0100692)2.09534685
98Keratoconus (HP:0000563)2.09534685
99Calcaneovalgus deformity (HP:0001848)2.09518992
100Delayed cranial suture closure (HP:0000270)2.07255957
101Reduced antithrombin III activity (HP:0001976)2.06924204
102Ketosis (HP:0001946)2.06735396
103Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06283218
104Abnormal delivery (HP:0001787)2.04296054
105Dynein arm defect of respiratory motile cilia (HP:0012255)2.03472310
106Absent/shortened dynein arms (HP:0200106)2.03472310
107Postaxial foot polydactyly (HP:0001830)2.03405606
108Respiratory failure (HP:0002878)2.02782033
109Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01948331
110Short nail (HP:0001799)2.00237083
111Abnormality of the pons (HP:0007361)1.99503193
112Abnormal hemoglobin (HP:0011902)1.99464823
113Hyperventilation (HP:0002883)1.99182827
114Spinal rigidity (HP:0003306)1.97282107
115Patent foramen ovale (HP:0001655)1.96665258
116Congenital, generalized hypertrichosis (HP:0004540)1.96502875
117Inability to walk (HP:0002540)1.95767072
118Trismus (HP:0000211)1.95566302
119Congenital hepatic fibrosis (HP:0002612)1.94345204
120Genital tract atresia (HP:0001827)1.94041466
121Abnormality of the fovea (HP:0000493)1.93573517
122Muscle fiber splitting (HP:0003555)1.92533879
123Median cleft lip (HP:0000161)1.91569556
124Abnormal drinking behavior (HP:0030082)1.91215746
125Polydipsia (HP:0001959)1.91215746
126Exercise intolerance (HP:0003546)1.88808603
127CNS hypomyelination (HP:0003429)1.87175966
128Gaze-evoked nystagmus (HP:0000640)1.86994061
129Broad face (HP:0000283)1.86832237
130Progressive neurologic deterioration (HP:0002344)1.86364166
131Pendular nystagmus (HP:0012043)1.85673889
132Rhinitis (HP:0012384)1.85636761
133Coxa vara (HP:0002812)1.85140791
134Adrenal hypoplasia (HP:0000835)1.83652917
135Postaxial hand polydactyly (HP:0001162)1.83029907
136Stenosis of the external auditory canal (HP:0000402)1.82759378
137Abnormality of macular pigmentation (HP:0008002)1.81848130
138Abnormal ciliary motility (HP:0012262)1.81760524
139Increased muscle lipid content (HP:0009058)1.80505203
140Occipital encephalocele (HP:0002085)1.78885247
141Joint stiffness (HP:0001387)1.78289632
142Round ear (HP:0100830)1.77698834
143Epiphyseal stippling (HP:0010655)1.76621080
144Flat capital femoral epiphysis (HP:0003370)1.76403779
145Sloping forehead (HP:0000340)1.76302433
146Optic disc pallor (HP:0000543)1.76160479
147Vaginal atresia (HP:0000148)1.76016014
148Bell-shaped thorax (HP:0001591)1.75690743
149Bony spicule pigmentary retinopathy (HP:0007737)1.75374923
150Abnormal respiratory epithelium morphology (HP:0012253)1.75235723
151Abnormal respiratory motile cilium morphology (HP:0005938)1.75235723
152Vacuolated lymphocytes (HP:0001922)1.74822649
153Aganglionic megacolon (HP:0002251)1.73992031
154Stillbirth (HP:0003826)1.72473005
155Cerebral edema (HP:0002181)1.72454640
156Stridor (HP:0010307)1.72447434
157Glycosuria (HP:0003076)1.72275091
158Abnormality of urine glucose concentration (HP:0011016)1.72275091
159Hypoplastic ischia (HP:0003175)1.72130695
160Abnormality of the labia minora (HP:0012880)1.71920525
161Meckel diverticulum (HP:0002245)1.71515677
162Abnormality of the umbilical cord (HP:0010881)1.70582198
163Lactic acidosis (HP:0003128)1.69423218
164Spastic paraparesis (HP:0002313)1.67591772
165Hypoplasia of the pons (HP:0012110)1.67360949
166Vascular tortuosity (HP:0004948)1.67323894
167Fibular aplasia (HP:0002990)1.67209847
168Broad metatarsal (HP:0001783)1.66907248
169Blue sclerae (HP:0000592)1.66248987
170Shallow orbits (HP:0000586)1.66095644
171Neonatal short-limb short stature (HP:0008921)1.65943545
172Abnormal trabecular bone morphology (HP:0100671)1.65888612
173Delusions (HP:0000746)1.65218708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME24.85798553
2LIMK13.08766965
3EIF2AK13.00643074
4INSRR2.89071800
5TESK22.76186537
6MOS2.58357989
7NUAK12.55070379
8EIF2AK32.49229152
9ACVR1B2.48830281
10PIM22.48250076
11PIK3CG2.39393092
12ADRBK22.39061233
13BUB12.36953570
14STK162.19123156
15MST42.12846753
16TESK12.08362626
17WNK32.01886725
18BCKDK1.96995221
19WEE11.95117612
20PBK1.91121163
21CDK191.79408283
22MUSK1.77223665
23MAPK131.65750950
24STK391.65505692
25MET1.65235040
26TRIM281.64223671
27FRK1.63537193
28GRK11.60123132
29ARAF1.58643736
30FLT31.50482829
31MAPKAPK51.49534896
32PNCK1.47934180
33DDR21.47838409
34MAP3K121.46374987
35LATS21.43176012
36SCYL21.39799454
37TRPM71.39758968
38MKNK11.37889717
39BMPR1B1.37080312
40MAP4K21.36906042
41ZAK1.33738097
42STK31.28269872
43KDR1.27002197
44WNK41.26241617
45MAP3K41.25072398
46DYRK21.24602314
47ILK1.23141320
48PIK3CA1.21529294
49BRAF1.19164981
50LATS11.15654213
51RPS6KA41.10225449
52ABL21.07882856
53VRK11.07229250
54BRSK21.00962449
55EPHA21.00305793
56NEK61.00024935
57CSNK1G30.96398722
58MAPKAPK30.96257746
59BMPR20.94577987
60PAK20.94556764
61PRKCE0.94513719
62MAP2K70.93489657
63MYLK0.92421342
64NME10.90234292
65FGFR20.89017129
66TNIK0.88403307
67ERBB30.87228330
68ADRBK10.86574410
69PRKCI0.85903864
70TLK10.84918394
71IRAK30.84459795
72CASK0.82902741
73BCR0.82179104
74JAK30.81645042
75VRK20.80995958
76AURKA0.80418810
77PLK20.79387649
78PLK40.79337405
79LRRK20.78999674
80CDK80.77944940
81PRKG20.76142168
82PAK10.74500470
83MAP3K30.74399773
84OXSR10.73660798
85CCNB10.73018073
86PRKCG0.72893530
87NEK10.71064985
88ERBB40.69909790
89MAP2K60.69680903
90CSNK1G10.69408048
91CAMKK20.67905357
92CSNK1G20.67388251
93CDK30.67368270
94CDK70.67219484
95PLK30.67194175
96RAF10.66870586
97DAPK30.66627285
98PLK10.65394926
99PHKG10.65386906
100PHKG20.65386906
101MAP3K110.64957622
102EIF2AK20.64337653
103ATR0.63670192
104NEK20.63344991
105ROCK20.63115255
106NEK90.61059811
107TGFBR10.60069156
108MARK30.59150952
109CSNK1A1L0.58430317
110MAP3K80.57333051
111FER0.56634339
112NTRK10.56157719
113CDC70.55528287
114ZAP700.55300911
115TSSK60.54982464
116OBSCN0.54964689
117CAMK2D0.54041579
118AURKB0.54011370
119DAPK20.53832484
120ATM0.53689398
121IKBKB0.52418506
122CHEK20.52370375
123TAOK30.48991312
124PDK20.48951873
125MKNK20.48800154
126TTN0.48551584
127SRPK10.47742180
128PTK2B0.47513357
129TTK0.47449556
130PINK10.46238332
131PAK30.46221876
132PASK0.45295155
133PKN10.44537326
134GRK70.44017604
135BLK0.43906582
136IRAK10.43594169
137PAK40.43476628
138RPS6KA50.42585191
139CAMK2G0.41004302
140PTK20.40508639
141STK38L0.40214208
142RPS6KB20.40065648
143TXK0.38324165
144MAPK150.38227599
145TEC0.38199197
146KIT0.37797964
147CSNK2A20.37338134
148CSNK1A10.37151414
149CAMK2A0.36479723

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.70383866
2Ribosome_Homo sapiens_hsa030103.93698223
3Proteasome_Homo sapiens_hsa030503.72870657
4RNA polymerase_Homo sapiens_hsa030203.31267713
5Folate biosynthesis_Homo sapiens_hsa007902.88445274
6DNA replication_Homo sapiens_hsa030302.70249020
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.67863876
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.57489273
9Butanoate metabolism_Homo sapiens_hsa006502.54394823
10Oxidative phosphorylation_Homo sapiens_hsa001902.44859212
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.43693503
12Nucleotide excision repair_Homo sapiens_hsa034202.37722177
13Tryptophan metabolism_Homo sapiens_hsa003802.24116793
14Parkinsons disease_Homo sapiens_hsa050122.19872974
15Phototransduction_Homo sapiens_hsa047442.15439913
16Caffeine metabolism_Homo sapiens_hsa002322.08854868
17Pyrimidine metabolism_Homo sapiens_hsa002402.02017720
18Mismatch repair_Homo sapiens_hsa034301.99910812
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.92889779
20Steroid biosynthesis_Homo sapiens_hsa001001.76078709
21Propanoate metabolism_Homo sapiens_hsa006401.70672666
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67780962
23Basal transcription factors_Homo sapiens_hsa030221.67070449
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65749175
25Fatty acid elongation_Homo sapiens_hsa000621.63386002
26Linoleic acid metabolism_Homo sapiens_hsa005911.62713464
27Huntingtons disease_Homo sapiens_hsa050161.53168691
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47968669
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.47403872
30One carbon pool by folate_Homo sapiens_hsa006701.46964147
31Nitrogen metabolism_Homo sapiens_hsa009101.44371069
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43153759
33RNA transport_Homo sapiens_hsa030131.42689153
34SNARE interactions in vesicular transport_Homo sapiens_hsa041301.40839364
35p53 signaling pathway_Homo sapiens_hsa041151.40343240
36Homologous recombination_Homo sapiens_hsa034401.35331139
37RNA degradation_Homo sapiens_hsa030181.35263347
38ECM-receptor interaction_Homo sapiens_hsa045121.34639638
39N-Glycan biosynthesis_Homo sapiens_hsa005101.32202991
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.30868653
41Spliceosome_Homo sapiens_hsa030401.28642066
42Cell cycle_Homo sapiens_hsa041101.27939341
43Purine metabolism_Homo sapiens_hsa002301.27621341
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.26849569
45Sulfur relay system_Homo sapiens_hsa041221.26020927
46Alzheimers disease_Homo sapiens_hsa050101.24332894
47alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21123169
48Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.20835043
49Glutathione metabolism_Homo sapiens_hsa004801.20225368
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.19407115
51Other glycan degradation_Homo sapiens_hsa005111.18406482
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17398248
53Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14644526
54Steroid hormone biosynthesis_Homo sapiens_hsa001401.14247800
55Circadian rhythm_Homo sapiens_hsa047101.13772508
56Vibrio cholerae infection_Homo sapiens_hsa051101.13294735
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.10689997
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08672689
59Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.07023933
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05142054
61Phagosome_Homo sapiens_hsa041451.02220971
62Olfactory transduction_Homo sapiens_hsa047401.01856404
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00969883
64Chemical carcinogenesis_Homo sapiens_hsa052040.98194078
65Malaria_Homo sapiens_hsa051440.98073977
66ABC transporters_Homo sapiens_hsa020100.92101073
67Arginine and proline metabolism_Homo sapiens_hsa003300.92076847
68Sphingolipid metabolism_Homo sapiens_hsa006000.89455488
69Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88121089
70Collecting duct acid secretion_Homo sapiens_hsa049660.85521246
71Base excision repair_Homo sapiens_hsa034100.82744898
72Taste transduction_Homo sapiens_hsa047420.81243018
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79691877
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79363121
75Arachidonic acid metabolism_Homo sapiens_hsa005900.78127543
76Nicotine addiction_Homo sapiens_hsa050330.77192891
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.76581215
78Shigellosis_Homo sapiens_hsa051310.74941705
79Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73877350
80Fatty acid metabolism_Homo sapiens_hsa012120.73593685
81Rheumatoid arthritis_Homo sapiens_hsa053230.73412374
82Lysosome_Homo sapiens_hsa041420.72476502
83Focal adhesion_Homo sapiens_hsa045100.72247026
84Retinol metabolism_Homo sapiens_hsa008300.71647327
85PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69250754
86TGF-beta signaling pathway_Homo sapiens_hsa043500.68578919
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67338670
88Legionellosis_Homo sapiens_hsa051340.65543709
89beta-Alanine metabolism_Homo sapiens_hsa004100.65461773
90Tyrosine metabolism_Homo sapiens_hsa003500.63767871
91Ether lipid metabolism_Homo sapiens_hsa005650.61916360
92Metabolic pathways_Homo sapiens_hsa011000.61452579
93Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61193874
94Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61172932
95Non-homologous end-joining_Homo sapiens_hsa034500.60812548
96Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59861618
97Thyroid cancer_Homo sapiens_hsa052160.57878778
98Vitamin B6 metabolism_Homo sapiens_hsa007500.53937230
99Epstein-Barr virus infection_Homo sapiens_hsa051690.52542767
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.51258114
101Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50693424
102Phenylalanine metabolism_Homo sapiens_hsa003600.50312037
103Bladder cancer_Homo sapiens_hsa052190.50302072
104Melanoma_Homo sapiens_hsa052180.49477668
105Sulfur metabolism_Homo sapiens_hsa009200.49284222
106Fatty acid degradation_Homo sapiens_hsa000710.49276239
107Insulin secretion_Homo sapiens_hsa049110.47140143
108Pertussis_Homo sapiens_hsa051330.46368072
109Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.43855341
110Viral carcinogenesis_Homo sapiens_hsa052030.42926753
111Serotonergic synapse_Homo sapiens_hsa047260.42709205
112Type I diabetes mellitus_Homo sapiens_hsa049400.40253918
113Peroxisome_Homo sapiens_hsa041460.40083597
114Fanconi anemia pathway_Homo sapiens_hsa034600.39948031
115Small cell lung cancer_Homo sapiens_hsa052220.39751674
116Leishmaniasis_Homo sapiens_hsa051400.36733416
117Pyruvate metabolism_Homo sapiens_hsa006200.36054017
118Mineral absorption_Homo sapiens_hsa049780.35930383
119Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35529614
120Renal cell carcinoma_Homo sapiens_hsa052110.34993232
121Apoptosis_Homo sapiens_hsa042100.34733508
122Protein digestion and absorption_Homo sapiens_hsa049740.33770097
123Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33035938
124Selenocompound metabolism_Homo sapiens_hsa004500.30588173
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.30389384
126Cardiac muscle contraction_Homo sapiens_hsa042600.29971649
127Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.29490847
128Systemic lupus erythematosus_Homo sapiens_hsa053220.29128021
129Salmonella infection_Homo sapiens_hsa051320.28978678
130Cyanoamino acid metabolism_Homo sapiens_hsa004600.28768552
131Proteoglycans in cancer_Homo sapiens_hsa052050.28435532
132Ovarian steroidogenesis_Homo sapiens_hsa049130.26981478
133Prostate cancer_Homo sapiens_hsa052150.25410253
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.25088107
135Morphine addiction_Homo sapiens_hsa050320.24635226
136Circadian entrainment_Homo sapiens_hsa047130.24276862
137Leukocyte transendothelial migration_Homo sapiens_hsa046700.23352829
138Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.23037191
139Regulation of autophagy_Homo sapiens_hsa041400.21307477
140Pathways in cancer_Homo sapiens_hsa052000.17478731
141Galactose metabolism_Homo sapiens_hsa000520.16658644
142Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16105215
143Amoebiasis_Homo sapiens_hsa051460.16004549
144Platelet activation_Homo sapiens_hsa046110.15943569
145Hippo signaling pathway_Homo sapiens_hsa043900.14247425
146Renin-angiotensin system_Homo sapiens_hsa046140.13843569

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