TMEM45A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of skin barrier (GO:0061436)8.09891763
2regulation of water loss via skin (GO:0033561)8.00730917
3keratinocyte proliferation (GO:0043616)7.99852472
4sphingoid metabolic process (GO:0046519)7.70057143
5regulation of phospholipase A2 activity (GO:0032429)6.60975113
6sphingosine metabolic process (GO:0006670)6.26559505
7keratinization (GO:0031424)6.15130791
8keratinocyte differentiation (GO:0030216)5.92156675
9diol metabolic process (GO:0034311)5.85201599
10multicellular organismal water homeostasis (GO:0050891)5.40421997
11viral transcription (GO:0019083)5.33552571
12positive regulation of developmental pigmentation (GO:0048087)5.31557991
13regulation of pigment cell differentiation (GO:0050932)5.29065834
14hemidesmosome assembly (GO:0031581)5.14907297
15translational termination (GO:0006415)5.02035848
16ribosomal small subunit biogenesis (GO:0042274)4.75067728
17epidermal cell differentiation (GO:0009913)4.72867353
18negative regulation of keratinocyte proliferation (GO:0010839)4.70976392
19detection of bacterium (GO:0016045)4.67624118
20glucosamine-containing compound catabolic process (GO:1901072)4.66054288
21skin morphogenesis (GO:0043589)4.65487580
22endosome to pigment granule transport (GO:0043485)4.56510377
23endosome to melanosome transport (GO:0035646)4.56510377
24water homeostasis (GO:0030104)4.55432470
25peptide cross-linking (GO:0018149)4.53538977
26snRNA transcription (GO:0009301)4.53395807
27regulation of ruffle assembly (GO:1900027)4.52205700
28bundle of His cell to Purkinje myocyte communication (GO:0086069)4.46737510
29epidermis development (GO:0008544)4.36190533
30negative regulation of translation, ncRNA-mediated (GO:0040033)4.30449857
31regulation of translation, ncRNA-mediated (GO:0045974)4.30449857
32negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.30449857
33positive regulation of hair cycle (GO:0042635)4.27887763
34positive regulation of hair follicle development (GO:0051798)4.27887763
35intermediate filament organization (GO:0045109)4.24626065
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.22778572
37regulation of chemokine secretion (GO:0090196)4.21729416
38protein targeting to ER (GO:0045047)4.17294848
39establishment of protein localization to Golgi (GO:0072600)4.16749188
40cotranslational protein targeting to membrane (GO:0006613)4.13380894
41indole-containing compound catabolic process (GO:0042436)4.11604105
42indolalkylamine catabolic process (GO:0046218)4.11604105
43tryptophan catabolic process (GO:0006569)4.11604105
44regulation of hypersensitivity (GO:0002883)4.11017497
45interkinetic nuclear migration (GO:0022027)4.10749548
46keratinocyte development (GO:0003334)4.07131395
47establishment of protein localization to endoplasmic reticulum (GO:0072599)4.06133310
48kynurenine metabolic process (GO:0070189)4.05636701
49negative regulation of sodium ion transport (GO:0010766)4.05537746
50lymph vessel development (GO:0001945)4.04997010
51regulation of establishment of cell polarity (GO:2000114)4.04613880
52interferon-gamma secretion (GO:0072643)4.04277754
53molting cycle (GO:0042303)4.02649160
54hair cycle (GO:0042633)4.02649160
55positive regulation of chemokine secretion (GO:0090197)4.02285640
56detection of other organism (GO:0098543)3.99184283
57negative regulation of interferon-gamma production (GO:0032689)3.97029800
58negative regulation of protein localization to cell surface (GO:2000009)3.95540579
59viral life cycle (GO:0019058)3.93291991
60regulation of cell proliferation involved in kidney development (GO:1901722)3.92305223
61translational elongation (GO:0006414)3.90299239
62protein localization to endoplasmic reticulum (GO:0070972)3.87621860
63signal peptide processing (GO:0006465)3.85140360
64positive regulation of interleukin-8 secretion (GO:2000484)3.83096145
65regulation of hippo signaling (GO:0035330)3.82386858
66protein K48-linked deubiquitination (GO:0071108)3.80344052
67cellular protein complex disassembly (GO:0043624)3.76437816
68regulation of interleukin-8 secretion (GO:2000482)3.74185856
69monoubiquitinated protein deubiquitination (GO:0035520)3.73089376
70negative regulation of systemic arterial blood pressure (GO:0003085)3.69815712
71maturation of SSU-rRNA (GO:0030490)3.68873751
72indolalkylamine metabolic process (GO:0006586)3.68543746
73synaptic vesicle docking involved in exocytosis (GO:0016081)3.68008168
74gland morphogenesis (GO:0022612)3.67886891
75fatty acid elongation (GO:0030497)3.66326122
76negative regulation of acute inflammatory response (GO:0002674)3.62810912
77tryptophan metabolic process (GO:0006568)3.57932727
78behavioral response to nicotine (GO:0035095)3.57711180
79protein targeting to lysosome (GO:0006622)3.57614806
80establishment of protein localization to vacuole (GO:0072666)3.57614806
81protein targeting to vacuole (GO:0006623)3.57614806
82lipid translocation (GO:0034204)3.56163160
83phospholipid translocation (GO:0045332)3.56163160
84regulation of establishment or maintenance of cell polarity (GO:0032878)3.56028925
85regulation of natural killer cell differentiation (GO:0032823)3.55350289
86oxidative demethylation (GO:0070989)3.55235150
87regulation of posttranscriptional gene silencing (GO:0060147)3.53819862
88regulation of gene silencing by miRNA (GO:0060964)3.53819862
89regulation of gene silencing by RNA (GO:0060966)3.53819862
90flavonoid metabolic process (GO:0009812)3.53133888
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.51952269
92cilium or flagellum-dependent cell motility (GO:0001539)3.50176529
93response to phenylpropanoid (GO:0080184)3.50104224
94regulation of hair follicle development (GO:0051797)3.47427908
95endocardial cushion development (GO:0003197)3.46617906
96atrioventricular valve morphogenesis (GO:0003181)3.43148439
97atrial cardiac muscle cell action potential (GO:0086014)3.42413819
98pericardium development (GO:0060039)3.42287778
99neural tube formation (GO:0001841)3.41638392
100glucocorticoid receptor signaling pathway (GO:0042921)3.39076851
101cyclooxygenase pathway (GO:0019371)3.37926500
102regulation of apoptotic process involved in morphogenesis (GO:1902337)3.37890401
103cytoplasmic mRNA processing body assembly (GO:0033962)3.36411878
104neural crest cell development (GO:0014032)3.34359704
105cellular response to ethanol (GO:0071361)3.28074749
106negative regulation of kidney development (GO:0090185)3.28046078
107negative regulation of T cell mediated immunity (GO:0002710)3.27975918
108negative regulation of cell fate commitment (GO:0010454)3.26745299
109reflex (GO:0060004)3.23788744
110negative regulation of interleukin-2 production (GO:0032703)3.23228585
111negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.22926128
112cardiovascular system development (GO:0072358)3.22413292
113negative regulation of cell fate specification (GO:0009996)3.21660652
114cellular response to interferon-alpha (GO:0035457)3.20078796
115positive regulation of epidermis development (GO:0045684)3.19211507
116detection of light stimulus involved in sensory perception (GO:0050962)3.18655931
117detection of light stimulus involved in visual perception (GO:0050908)3.18655931
118cardiac right ventricle morphogenesis (GO:0003215)3.13438447
119positive regulation of vesicle fusion (GO:0031340)3.12188692
120negative regulation of stress fiber assembly (GO:0051497)3.11774168
121regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.11115823
122limb bud formation (GO:0060174)3.10463183
123protein complex disassembly (GO:0043241)3.08381867
124eyelid development in camera-type eye (GO:0061029)3.08351177
125planar cell polarity pathway involved in neural tube closure (GO:0090179)3.06932849
126phospholipid scrambling (GO:0017121)3.06859737
127sulfation (GO:0051923)3.06770724
128gamma-aminobutyric acid transport (GO:0015812)3.06135225
129protein targeting to membrane (GO:0006612)3.05454505
130ribosomal large subunit biogenesis (GO:0042273)3.04641150
131translational initiation (GO:0006413)3.03790275
132regulation of keratinocyte proliferation (GO:0010837)3.03285604
133G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.01659991
134protein K63-linked deubiquitination (GO:0070536)3.00507935
135serotonin metabolic process (GO:0042428)2.99658025
136ribosomal small subunit assembly (GO:0000028)2.99278945
137negative regulation of activin receptor signaling pathway (GO:0032926)2.98379444
138ectoderm development (GO:0007398)2.97739790
139regulation of glomerular filtration (GO:0003093)2.96610893
140indole-containing compound metabolic process (GO:0042430)2.96071298
141protein K11-linked deubiquitination (GO:0035871)2.95102051
142fucose catabolic process (GO:0019317)2.92646375
143L-fucose metabolic process (GO:0042354)2.92646375
144L-fucose catabolic process (GO:0042355)2.92646375
145germ cell migration (GO:0008354)2.92467434
146regulation of transforming growth factor beta1 production (GO:0032908)2.92122323
147heart valve morphogenesis (GO:0003179)2.90915423
148positive regulation of interleukin-4 production (GO:0032753)2.89870347
149thyroid hormone metabolic process (GO:0042403)2.89220108
150cellular response to sterol (GO:0036315)2.87409822
151skeletal muscle tissue regeneration (GO:0043403)2.86738520
152negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.86730449
153collagen fibril organization (GO:0030199)2.85848296
154macromolecular complex disassembly (GO:0032984)2.83646211
155epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.83389080
156regulation of hair cycle (GO:0042634)2.82650395
157primary amino compound metabolic process (GO:1901160)2.79310094
158establishment of planar polarity (GO:0001736)2.79007592
159establishment of tissue polarity (GO:0007164)2.79007592
160hair follicle morphogenesis (GO:0031069)2.78294448
161prostaglandin biosynthetic process (GO:0001516)2.78120928
162prostanoid biosynthetic process (GO:0046457)2.78120928
163primary alcohol catabolic process (GO:0034310)2.76133400
164regulation of developmental pigmentation (GO:0048070)2.75250299
165regulation of sarcomere organization (GO:0060297)2.70461682
166NAD biosynthetic process (GO:0009435)2.70342210
167corticosteroid receptor signaling pathway (GO:0031958)2.68414480
168striated muscle atrophy (GO:0014891)2.67299756
169detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.67253169
170photoreceptor cell maintenance (GO:0045494)2.65648369
171cellular ketone body metabolic process (GO:0046950)2.65607125
172positive regulation of CREB transcription factor activity (GO:0032793)2.64415414
173cerebellar Purkinje cell differentiation (GO:0021702)2.63604616
174cell morphogenesis involved in neuron differentiation (GO:0048667)2.62711569
175histone-serine phosphorylation (GO:0035404)2.62030253
176cornea development in camera-type eye (GO:0061303)2.58141751
177UDP-N-acetylglucosamine metabolic process (GO:0006047)2.57088002
178response to pheromone (GO:0019236)2.53054399
179protein targeting to Golgi (GO:0000042)2.52442958
180limb development (GO:0060173)2.50730258
181appendage development (GO:0048736)2.50730258
182regulation of mesoderm development (GO:2000380)2.50280547
183regulation of short-term neuronal synaptic plasticity (GO:0048172)2.49044085
184ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.47497487
185retrograde transport, vesicle recycling within Golgi (GO:0000301)2.46286233
186regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.44977035
187sympathetic nervous system development (GO:0048485)2.44257576
188neuronal action potential (GO:0019228)2.44247066
189nucleus localization (GO:0051647)2.43343586
190pigment cell differentiation (GO:0050931)2.41512231
191microtubule anchoring (GO:0034453)2.40066806
192skeletal muscle adaptation (GO:0043501)2.37987445
193phosphatidylinositol acyl-chain remodeling (GO:0036149)2.32883048
194ketone body metabolic process (GO:1902224)2.32654392
195peristalsis (GO:0030432)2.32338248
196desmosome organization (GO:0002934)13.6725836

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse7.50246832
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.70722246
3GBX2_23144817_ChIP-Seq_PC3_Human3.16680706
4SOX9_24532713_ChIP-Seq_HFSC_Mouse2.98501006
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.82192036
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75874999
7P63_26484246_Chip-Seq_KERATINOCYTES_Human2.62521251
8VDR_22108803_ChIP-Seq_LS180_Human2.58925945
9EZH2_22144423_ChIP-Seq_EOC_Human2.51842053
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51323267
11ZNF274_21170338_ChIP-Seq_K562_Hela2.48097984
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.48073690
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.46339104
14SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.46013249
15TAF15_26573619_Chip-Seq_HEK293_Human2.41187048
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.40987276
17SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.21763375
18CTBP2_25329375_ChIP-Seq_LNCAP_Human2.19464639
19* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.14001559
20SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.03221939
21SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.03221939
22TP63_17297297_ChIP-ChIP_HaCaT_Human14.7335398
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.98395899
24STAT3_23295773_ChIP-Seq_U87_Human1.98090618
25EWS_26573619_Chip-Seq_HEK293_Human1.96441861
26P300_19829295_ChIP-Seq_ESCs_Human1.92884565
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.92627919
28FUS_26573619_Chip-Seq_HEK293_Human1.89089789
29AR_21572438_ChIP-Seq_LNCaP_Human1.88538029
30ER_23166858_ChIP-Seq_MCF-7_Human1.86715175
31ESR2_21235772_ChIP-Seq_MCF-7_Human1.84619660
32SMAD4_21799915_ChIP-Seq_A2780_Human1.82696217
33STAT6_21828071_ChIP-Seq_BEAS2B_Human1.79676118
34* CJUN_26792858_Chip-Seq_BT549_Human1.78921680
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.77624866
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76912361
37IGF1R_20145208_ChIP-Seq_DFB_Human1.76166445
38FLI1_27457419_Chip-Seq_LIVER_Mouse1.76147705
39NR3C1_21868756_ChIP-Seq_MCF10A_Human1.74384475
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71708590
41ZNF217_24962896_ChIP-Seq_MCF-7_Human1.70958506
42* SOX2_20726797_ChIP-Seq_SW620_Human1.65171549
43* TCF4_23295773_ChIP-Seq_U87_Human1.63814519
44UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.63199187
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.60551276
46GATA1_22025678_ChIP-Seq_K562_Human1.59496339
47TP53_18474530_ChIP-ChIP_U2OS_Human1.56919344
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56270607
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.53837416
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53837416
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.53376404
52AR_25329375_ChIP-Seq_VCAP_Human1.52864756
53MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.52851970
54PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50954719
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.49952799
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48879646
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46128874
58TP63_23658742_ChIP-Seq_EP156T_Human1.43113044
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41835339
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.40728236
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40099215
62DROSHA_22980978_ChIP-Seq_HELA_Human1.36409382
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.35971224
64TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34257632
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34023290
66SMAD_19615063_ChIP-ChIP_OVARY_Human1.33742775
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.31506848
68* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.31257477
69* CBP_20019798_ChIP-Seq_JUKART_Human1.31257477
70RUNX2_22187159_ChIP-Seq_PCA_Human1.30935968
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.30589950
72TCF4_18268006_ChIP-ChIP_LS174T_Human1.29797933
73ZNF263_19887448_ChIP-Seq_K562_Human1.29746800
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29155365
75SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28981001
76SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.23435951
77FLI1_21867929_ChIP-Seq_TH2_Mouse1.22374392
78SUZ12_27294783_Chip-Seq_NPCs_Mouse1.22185897
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.22101822
80CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21542504
81CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.21147788
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.20035236
83EZH2_27294783_Chip-Seq_NPCs_Mouse1.19896617
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19403959
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18699939
86ESR1_20079471_ChIP-ChIP_T-47D_Human1.17831202
87* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17430606
88CDX2_20551321_ChIP-Seq_CACO-2_Human1.16918008
89EZH2_27304074_Chip-Seq_ESCs_Mouse1.15520580
90STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.14358103
91ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.13867351
92EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.13403254
93BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.12879925
94KLF5_25053715_ChIP-Seq_YYC3_Human1.11565904
95* KDM2B_26808549_Chip-Seq_REH_Human1.11225817
96TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10983712
97NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09777898
98NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09777898
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.09510765
100ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08918062
101RUNX1_27514584_Chip-Seq_MCF-7_Human1.08132003
102TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.07488471
103NFE2_27457419_Chip-Seq_LIVER_Mouse1.07450010
104REST_21632747_ChIP-Seq_MESCs_Mouse1.06689843
105EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06368419
106TP53_16413492_ChIP-PET_HCT116_Human1.05215376
107* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.05143469
108KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05134084
109RXR_22108803_ChIP-Seq_LS180_Human1.04809950
110GATA3_24758297_ChIP-Seq_MCF-7_Human1.04524996
111AR_19668381_ChIP-Seq_PC3_Human1.04473150
112CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04250591
113SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.03570590
114SMAD3_21741376_ChIP-Seq_ESCs_Human1.02762183
115RNF2_27304074_Chip-Seq_NSC_Mouse1.02369135
116AHR_22903824_ChIP-Seq_MCF-7_Human1.02340661
117* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02114293
118SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.01950798
119CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.01717105
120TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01488334
121CDX2_22108803_ChIP-Seq_LS180_Human1.01452712
122KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01160908
123* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00732561
124SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00693813
125GATA4_25053715_ChIP-Seq_YYC3_Human1.00334424
126STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00278032
127CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00257192
128P53_22127205_ChIP-Seq_FIBROBLAST_Human0.99709564
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.99614670
130FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.99121384
131BCAT_22108803_ChIP-Seq_LS180_Human0.92360526
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91950431
133UBF1/2_26484160_Chip-Seq_HMECs_Human0.89962071
134ATF3_27146783_Chip-Seq_COLON_Human0.89556380
135ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88457105
136JARID2_20075857_ChIP-Seq_MESCs_Mouse0.86511916
137PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.86246934
138* TP63_22573176_ChIP-Seq_HFKS_Human0.85925283
139HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85585388
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.85319590
141RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85249149
142EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85249149
143FOXM1_26456572_ChIP-Seq_MCF-7_Human0.84732843
144KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.84658181
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84496457
146SRY_22984422_ChIP-ChIP_TESTIS_Rat0.84041730
147WT1_19549856_ChIP-ChIP_CCG9911_Human0.83645090
148BMI1_23680149_ChIP-Seq_NPCS_Mouse0.83375906
149CLOCK_20551151_ChIP-Seq_293T_Human0.82165258
150RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80693018
151FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80416223
152SUZ12_27294783_Chip-Seq_ESCs_Mouse0.79182058
153CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.78736096
154RACK7_27058665_Chip-Seq_MCF-7_Human0.77623172
155SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.76882573
156PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.76471156
157CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.76419477
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.75775792
159GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.75469951
160FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.73706321
161JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72921551
162* TCF4_22108803_ChIP-Seq_LS180_Human0.71768777
163JARID2_20064375_ChIP-Seq_MESCs_Mouse0.71131304
164EP300_21415370_ChIP-Seq_HL-1_Mouse0.70082704
165RNF2_27304074_Chip-Seq_ESCs_Mouse0.69122353
166GATA6_25053715_ChIP-Seq_YYC3_Human0.69061134
167NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.67701158
168ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.67661612
169CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67096067
170CBX2_27304074_Chip-Seq_ESCs_Mouse0.66778165
171EZH2_27294783_Chip-Seq_ESCs_Mouse0.66424289
172SMAD3_21741376_ChIP-Seq_HESCs_Human0.66209340
173PIAS1_25552417_ChIP-Seq_VCAP_Human0.65128203
174SOX2_27498859_Chip-Seq_STOMACH_Mouse0.64658970
175UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.64372259
176SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.64091297
177ELK1_22589737_ChIP-Seq_MCF10A_Human0.63006887

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002796_impaired_skin_barrier6.42555412
2MP0005275_abnormal_skin_tensile5.45389828
3MP0000569_abnormal_digit_pigmentation5.19429197
4MP0010234_abnormal_vibrissa_follicle4.88146609
5MP0003941_abnormal_skin_development4.68169385
6MP0008057_abnormal_DNA_replication4.51034864
7MP0005501_abnormal_skin_physiology3.92222615
8MP0004381_abnormal_hair_follicle3.66347906
9MP0003646_muscle_fatigue3.63968491
10MP0002060_abnormal_skin_morphology3.54631029
11MP0003705_abnormal_hypodermis_morpholog3.30072198
12MP0004043_abnormal_pH_regulation3.17348261
13MP0002254_reproductive_system_inflammat3.02988826
14MP0002098_abnormal_vibrissa_morphology3.00503201
15MP0001216_abnormal_epidermal_layer2.97912178
16MP0009046_muscle_twitch2.78548498
17MP0000383_abnormal_hair_follicle2.75333036
18MP0010678_abnormal_skin_adnexa2.71592699
19MP0010771_integument_phenotype2.68006816
20MP0003890_abnormal_embryonic-extraembry2.61039965
21MP0000579_abnormal_nail_morphology2.59519710
22MP0003453_abnormal_keratinocyte_physiol2.52005249
23MP0002009_preneoplasia2.50159985
24MP0009379_abnormal_foot_pigmentation2.49801836
25MP0008438_abnormal_cutaneous_collagen2.47263312
26MP0008961_abnormal_basal_metabolism2.42341807
27MP0001346_abnormal_lacrimal_gland2.40920238
28MP0000377_abnormal_hair_follicle2.33846099
29MP0000647_abnormal_sebaceous_gland2.30039664
30MP0009384_cardiac_valve_regurgitation2.14215300
31MP0005551_abnormal_eye_electrophysiolog2.03854676
32MP0003566_abnormal_cell_adhesion2.02259978
33MP0000467_abnormal_esophagus_morphology2.01720213
34MP0000566_synostosis1.97038938
35MP0001501_abnormal_sleep_pattern1.89702471
36MP0005174_abnormal_tail_pigmentation1.89380545
37MP0000427_abnormal_hair_cycle1.88985644
38MP0005451_abnormal_body_composition1.82406417
39MP0004130_abnormal_muscle_cell1.75541842
40MP0000762_abnormal_tongue_morphology1.74622660
41MP0005367_renal/urinary_system_phenotyp1.71547482
42MP0000516_abnormal_urinary_system1.71547482
43MP0004142_abnormal_muscle_tone1.69885170
44MP0003045_fibrosis1.68454410
45MP0004924_abnormal_behavior1.64792293
46MP0005386_behavior/neurological_phenoty1.64792293
47MP0004947_skin_inflammation1.64139438
48MP0001968_abnormal_touch/_nociception1.62956663
49MP0000537_abnormal_urethra_morphology1.56581072
50MP0001191_abnormal_skin_condition1.50797921
51MP0009745_abnormal_behavioral_response1.49966058
52MP0005503_abnormal_tendon_morphology1.46541561
53MP0009931_abnormal_skin_appearance1.46085724
54MP0001243_abnormal_dermal_layer1.43727185
55MP0003787_abnormal_imprinting1.41610394
56MP0002735_abnormal_chemical_nociception1.37203253
57MP0005171_absent_coat_pigmentation1.36518996
58MP0008877_abnormal_DNA_methylation1.34434257
59MP0002837_dystrophic_cardiac_calcinosis1.34078342
60MP0004272_abnormal_basement_membrane1.33750809
61MP0009053_abnormal_anal_canal1.30709428
62MP0002638_abnormal_pupillary_reflex1.29408992
63MP0005023_abnormal_wound_healing1.27122698
64MP0005645_abnormal_hypothalamus_physiol1.27048134
65MP0002095_abnormal_skin_pigmentation1.26006881
66MP0009250_abnormal_appendicular_skeleto1.25599355
67MP0004215_abnormal_myocardial_fiber1.22121855
68MP0005508_abnormal_skeleton_morphology1.20651202
69MP0003195_calcinosis1.18509629
70MP0003011_delayed_dark_adaptation1.17547941
71MP0005646_abnormal_pituitary_gland1.17390018
72MP0001851_eye_inflammation1.16640335
73MP0008872_abnormal_physiological_respon1.16487568
74MP0001986_abnormal_taste_sensitivity1.15402070
75MP0002064_seizures1.14836055
76MP0004185_abnormal_adipocyte_glucose1.14386994
77MP0005253_abnormal_eye_physiology1.13972963
78MP0010030_abnormal_orbit_morphology1.13668469
79MP0002282_abnormal_trachea_morphology1.13582087
80MP0002168_other_aberrant_phenotype1.13096388
81MP0002067_abnormal_sensory_capabilities1.12889968
82MP0001486_abnormal_startle_reflex1.12359091
83MP0005266_abnormal_metabolism1.12353917
84MP0000367_abnormal_coat/_hair1.11519463
85MP0010352_gastrointestinal_tract_polyps1.10484590
86MP0001188_hyperpigmentation1.10191416
87MP0001340_abnormal_eyelid_morphology1.09276235
88MP0002736_abnormal_nociception_after1.09158419
89MP0002928_abnormal_bile_duct1.08183195
90MP0004145_abnormal_muscle_electrophysio1.08017920
91MP0003937_abnormal_limbs/digits/tail_de1.07759805
92MP0002272_abnormal_nervous_system1.07201273
93MP0006054_spinal_hemorrhage1.06410257
94MP0001485_abnormal_pinna_reflex1.06385020
95MP0002938_white_spotting1.05704651
96MP0003315_abnormal_perineum_morphology1.05014222
97MP0004147_increased_porphyrin_level1.04070844
98MP0002572_abnormal_emotion/affect_behav1.02093663
99MP0002102_abnormal_ear_morphology1.01888436
100MP0001984_abnormal_olfaction1.01095164
101MP0002557_abnormal_social/conspecific_i1.01094178
102MP0000230_abnormal_systemic_arterial1.00277185
103MP0002249_abnormal_larynx_morphology0.99739639
104MP0009115_abnormal_fat_cell0.96314803
105MP0005623_abnormal_meninges_morphology0.95759974
106MP0000631_abnormal_neuroendocrine_gland0.95547289
107MP0006276_abnormal_autonomic_nervous0.94766405
108MP0001324_abnormal_eye_pigmentation0.94208061
109MP0003137_abnormal_impulse_conducting0.92488676
110MP0005448_abnormal_energy_balance0.91778197
111MP0003136_yellow_coat_color0.90501725
112MP0003119_abnormal_digestive_system0.90329461
113MP0002876_abnormal_thyroid_physiology0.90181342
114MP0002063_abnormal_learning/memory/cond0.89857646
115MP0003635_abnormal_synaptic_transmissio0.89136396
116MP0010386_abnormal_urinary_bladder0.89094941
117MP0000428_abnormal_craniofacial_morphol0.88763110
118MP0005167_abnormal_blood-brain_barrier0.88087633
119MP0003252_abnormal_bile_duct0.87093133
120MP0001542_abnormal_bone_strength0.86402468
121MP0001970_abnormal_pain_threshold0.84617192
122MP0002166_altered_tumor_susceptibility0.84269360
123MP0003755_abnormal_palate_morphology0.84156522
124MP0005395_other_phenotype0.83745636
125MP0001958_emphysema0.83525709
126MP0003632_abnormal_nervous_system0.83296465
127MP0003718_maternal_effect0.82093117
128MP0001440_abnormal_grooming_behavior0.81940766
129MP0005647_abnormal_sex_gland0.81882154
130MP0003385_abnormal_body_wall0.81373228
131MP0004885_abnormal_endolymph0.81215316
132MP0004484_altered_response_of0.81212841
133MP0000538_abnormal_urinary_bladder0.81106783
134MP0002295_abnormal_pulmonary_circulatio0.81020151
135MP0008004_abnormal_stomach_pH0.79568673
136MP0000371_diluted_coat_color0.78966280
137MP0000015_abnormal_ear_pigmentation0.78871767
138MP0000470_abnormal_stomach_morphology0.78454062
139MP0005390_skeleton_phenotype0.77677558
140MP0002006_tumorigenesis0.76928296
141MP0000627_abnormal_mammary_gland0.76686131
142MP0002733_abnormal_thermal_nociception0.76425485
143MP0004133_heterotaxia0.76082378
144MP0002160_abnormal_reproductive_system0.75864115
145MP0002877_abnormal_melanocyte_morpholog0.75189814
146MP0000778_abnormal_nervous_system0.75026204
147MP0002233_abnormal_nose_morphology0.74903550
148MP0010329_abnormal_lipoprotein_level0.74701248
149MP0002138_abnormal_hepatobiliary_system0.74504767
150MP0000465_gastrointestinal_hemorrhage0.74440042
151MP0005389_reproductive_system_phenotype0.72753070
152MP0005377_hearing/vestibular/ear_phenot0.71169525
153MP0005076_abnormal_cell_differentiation0.70057457
154MP0003279_aneurysm0.68869743
155MP0000163_abnormal_cartilage_morphology0.67256744
156MP0002177_abnormal_outer_ear0.66967506
157MP0002933_joint_inflammation0.65832488
158MP0002108_abnormal_muscle_morphology0.64870232
159MP0008789_abnormal_olfactory_epithelium0.64489559
160MP0000613_abnormal_salivary_gland0.63367674
161MP0010368_abnormal_lymphatic_system0.61435421
162MP0002234_abnormal_pharynx_morphology0.60483762
163MP0002896_abnormal_bone_mineralization0.58721009
164MP0002115_abnormal_skeleton_extremities0.58499209
165MP0003950_abnormal_plasma_membrane0.56302422
166MP0001533_abnormal_skeleton_physiology0.55663028
167MP0003436_decreased_susceptibility_to0.52224716
168MP0002111_abnormal_tail_morphology0.51108792
169MP0000432_abnormal_head_morphology0.48679155
170MP0001299_abnormal_eye_distance/0.47685276
171MP0001784_abnormal_fluid_regulation0.46870172
172MP0002109_abnormal_limb_morphology0.46658092
173MP0001879_abnormal_lymphatic_vessel0.45756321
174MP0003936_abnormal_reproductive_system0.43675593
175MP0005187_abnormal_penis_morphology0.43588011
176MP0000049_abnormal_middle_ear0.42909119
177MP0002277_abnormal_respiratory_mucosa0.39924661
178MP0003638_abnormal_response/metabolism_0.38890367
179MP0004264_abnormal_extraembryonic_tissu0.38232486
180MP0003942_abnormal_urinary_system0.37964605
181MP0002133_abnormal_respiratory_system0.37505650

Predicted human phenotypes

RankGene SetZ-score
1Hypotrichosis (HP:0001006)6.04317565
2Parakeratosis (HP:0001036)6.02864411
3Lip pit (HP:0100267)5.67241385
4Congenital nonbullous ichthyosiform erythroderma (HP:0007479)5.21780522
5Genetic anticipation (HP:0003743)5.03932616
6Right ventricular cardiomyopathy (HP:0011663)4.91713343
7Hyperventilation (HP:0002883)4.87484026
8Congenital ichthyosiform erythroderma (HP:0007431)4.87195892
9Woolly hair (HP:0002224)4.85184821
10Protruding tongue (HP:0010808)4.77545463
11Plantar hyperkeratosis (HP:0007556)4.77524662
12Erythema (HP:0010783)4.46833799
13Palmoplantar hyperkeratosis (HP:0000972)4.45389677
14Abnormality of secondary sexual hair (HP:0009888)4.37970832
15Abnormality of the axillary hair (HP:0100134)4.37970832
16Abnormality of nail color (HP:0100643)4.25155472
17Fragile nails (HP:0001808)4.24752329
18Increased IgE level (HP:0003212)4.23358033
19Pancreatic cysts (HP:0001737)4.14514696
20Palmar hyperkeratosis (HP:0010765)4.13983991
21Natal tooth (HP:0000695)4.04074904
22Progressive cerebellar ataxia (HP:0002073)3.67252389
23Sparse scalp hair (HP:0002209)3.67033213
24Onycholysis (HP:0001806)3.64898531
25Pancreatic fibrosis (HP:0100732)3.61680580
26Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.60828656
27Erythroderma (HP:0001019)3.58912364
28Fair hair (HP:0002286)3.57951427
29Clumsiness (HP:0002312)3.56279934
30Premature rupture of membranes (HP:0001788)3.55089113
31Birth length less than 3rd percentile (HP:0003561)3.54286461
32Gaze-evoked nystagmus (HP:0000640)3.51026044
33Popliteal pterygium (HP:0009756)3.42115461
34True hermaphroditism (HP:0010459)3.38169952
35Sparse eyelashes (HP:0000653)3.31227026
36Acanthosis nigricans (HP:0000956)3.30847548
37Aplasia/Hypoplasia of the tibia (HP:0005772)3.25241168
38Protrusio acetabuli (HP:0003179)3.22841259
39Distal lower limb muscle weakness (HP:0009053)3.13902012
40Advanced eruption of teeth (HP:0006288)3.09213107
41Concave nail (HP:0001598)3.07371973
42Abnormality of cells of the erythroid lineage (HP:0012130)3.05712655
43Abnormal hemoglobin (HP:0011902)3.02791190
44Atrophic scars (HP:0001075)2.97670360
45Abnormality of midbrain morphology (HP:0002418)2.96913312
46Molar tooth sign on MRI (HP:0002419)2.96913312
47Hypohidrosis (HP:0000966)2.96448207
48Patellar aplasia (HP:0006443)2.93747363
49Abnormality of the renal cortex (HP:0011035)2.92208014
50Abnormal blistering of the skin (HP:0008066)2.87614426
51Generalized hypopigmentation of hair (HP:0011358)2.84311503
52Increased neuronal autofluorescent lipopigment (HP:0002074)2.84203610
53Hypoplastic labia majora (HP:0000059)2.79522970
54Cystic liver disease (HP:0006706)2.79350908
55Nephronophthisis (HP:0000090)2.77472375
56Milia (HP:0001056)2.74071965
57Chronic hepatic failure (HP:0100626)2.73604635
58Abnormality of the renal medulla (HP:0100957)2.71448991
59Reticulocytopenia (HP:0001896)2.68497064
60Febrile seizures (HP:0002373)2.66833632
61Tubular atrophy (HP:0000092)2.65626464
62Aplasia involving bones of the extremities (HP:0009825)2.65133527
63Aplasia involving bones of the upper limbs (HP:0009823)2.65133527
64Aplasia of the phalanges of the hand (HP:0009802)2.65133527
65Corneal erosion (HP:0200020)2.64048185
66Aplasia/Hypoplasia of the patella (HP:0006498)2.63099691
67Oligodontia (HP:0000677)2.60368168
68Down-sloping shoulders (HP:0200021)2.60319784
69Abnormality of the distal phalanges of the toes (HP:0010182)2.59168978
70Breast hypoplasia (HP:0003187)2.57060324
71Hyporeflexia of lower limbs (HP:0002600)2.54518860
72Widely spaced teeth (HP:0000687)2.53581685
73Abnormality of the labia majora (HP:0012881)2.52448493
74Broad-based gait (HP:0002136)2.52352522
75Pili torti (HP:0003777)2.50039818
76Long nose (HP:0003189)2.48969837
77Attenuation of retinal blood vessels (HP:0007843)2.47362269
78Furrowed tongue (HP:0000221)2.47058973
79Congenital stationary night blindness (HP:0007642)2.46716394
80Anhidrosis (HP:0000970)2.44891509
81Abnormal number of erythroid precursors (HP:0012131)2.44844015
82Pterygium (HP:0001059)2.44257955
83Fragile skin (HP:0001030)2.44050016
84Severe Myopia (HP:0011003)2.41061997
85Medial flaring of the eyebrow (HP:0010747)2.41006155
86Congenital, generalized hypertrichosis (HP:0004540)2.40282458
87Ventricular tachycardia (HP:0004756)2.39634769
88Neonatal short-limb short stature (HP:0008921)2.36491645
89Nail dystrophy (HP:0008404)2.36432727
90Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.33886349
91Abnormality of alanine metabolism (HP:0010916)2.33886349
92Hyperalaninemia (HP:0003348)2.33886349
93Soft skin (HP:0000977)2.32265008
94Preaxial foot polydactyly (HP:0001841)2.31996691
95Inability to walk (HP:0002540)2.31871613
96Curly hair (HP:0002212)2.30484603
97Hypoplastic ischia (HP:0003175)2.30355005
98Abnormality of the ischium (HP:0003174)2.27966834
99Duplicated collecting system (HP:0000081)2.24834504
100Dysmetric saccades (HP:0000641)2.23997478
101Decreased circulating renin level (HP:0003351)2.22416619
102Aplasia/Hypoplasia of the tongue (HP:0010295)2.21185212
103Corneal dystrophy (HP:0001131)2.21027281
104Pruritus (HP:0000989)2.20842403
105Absent speech (HP:0001344)2.18604274
106Large for gestational age (HP:0001520)2.18016977
107Palmoplantar keratoderma (HP:0000982)2.17558267
108Gait imbalance (HP:0002141)2.15697924
109Macrocytic anemia (HP:0001972)2.14732829
110Peritonitis (HP:0002586)2.14430329
111Alopecia of scalp (HP:0002293)2.11695869
112Conjunctival hamartoma (HP:0100780)2.11047551
113Abnormality of the renal collecting system (HP:0004742)2.10822396
114Congenital primary aphakia (HP:0007707)2.09532367
115Hypoplasia of the iris (HP:0007676)2.09056430
116Thick nail (HP:0001805)2.08611280
117Abnormality of the nasal septum (HP:0000419)2.08147851
118Abnormality of the salivary glands (HP:0010286)2.07610270
119Drooling (HP:0002307)2.07103062
120Ectropion (HP:0000656)2.06218519
121Progressive inability to walk (HP:0002505)2.05157636
122Poor coordination (HP:0002370)2.03459278
123Increased cerebral lipofuscin (HP:0011813)2.02838041
124Abnormality of the 2nd finger (HP:0004100)2.00152161
125Genital tract atresia (HP:0001827)1.99671879
126Increased connective tissue (HP:0009025)1.99264454
127Hypodontia (HP:0000668)1.98768147
128Absent radius (HP:0003974)1.98510875
129Vaginal atresia (HP:0000148)1.97570999
130Preaxial hand polydactyly (HP:0001177)1.96421399
131Blue irides (HP:0000635)1.94581296
132Bifid scrotum (HP:0000048)1.92888809
133Macroglossia (HP:0000158)1.92334894
134Congenital hepatic fibrosis (HP:0002612)1.91661638
135Congenital sensorineural hearing impairment (HP:0008527)1.90331309
136Short foot (HP:0001773)1.90290503
137Septate vagina (HP:0001153)1.89893841
138Dry skin (HP:0000958)1.89867422
139Absent forearm bone (HP:0003953)1.89101337
140Aplasia involving forearm bones (HP:0009822)1.89101337
141Chorioretinal atrophy (HP:0000533)1.88872822
142Aplasia cutis congenita (HP:0001057)1.88561960
143Short hallux (HP:0010109)1.87644551
144Conical tooth (HP:0000698)1.87290287
145Gangrene (HP:0100758)1.86777526
146Trismus (HP:0000211)1.85727340
147Excessive salivation (HP:0003781)1.85469750
148Bulbous nose (HP:0000414)1.84960604
149Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.84786962
150Follicular hyperkeratosis (HP:0007502)1.84153889
151Bronchomalacia (HP:0002780)1.83715321
152Ridged nail (HP:0001807)1.83416038
153Vertebral compression fractures (HP:0002953)1.81341170
154Hypoplasia of dental enamel (HP:0006297)1.81105424
155Nephrogenic diabetes insipidus (HP:0009806)1.81003938
156Tracheomalacia (HP:0002779)1.80125924
157Underdeveloped nasal alae (HP:0000430)1.78298898
158Dialeptic seizures (HP:0011146)1.77837445
159Upper limb muscle weakness (HP:0003484)1.77686303
160Lissencephaly (HP:0001339)1.77593254
161Polydipsia (HP:0001959)1.77422655
162Abnormal drinking behavior (HP:0030082)1.77422655
163Clubbing of toes (HP:0100760)1.77041966
164Anencephaly (HP:0002323)1.76539206
165Brittle hair (HP:0002299)1.76493475
166Labial hypoplasia (HP:0000066)1.76226969
167Pallor (HP:0000980)1.75654387
168Abnormality of the gastric mucosa (HP:0004295)1.75296375
169Overgrowth (HP:0001548)1.74909814
170Abnormal vertebral ossification (HP:0100569)1.73760266
171Microtia (HP:0008551)1.73451301
172Abnormality of the phalanges of the 2nd finger (HP:0009541)1.71884559
173Stenosis of the external auditory canal (HP:0000402)1.71350203
174Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.71170871
175Abnormality of the phalanges of the 5th finger (HP:0004213)1.71115058
176Bony spicule pigmentary retinopathy (HP:0007737)1.69431888
177Small hand (HP:0200055)1.68360146
178Dynein arm defect of respiratory motile cilia (HP:0012255)1.68285930
179Absent/shortened dynein arms (HP:0200106)1.68285930
180Wormian bones (HP:0002645)1.68156401
181Aplasia/Hypoplasia of the hallux (HP:0008362)1.67962484
182Cerebellar dysplasia (HP:0007033)1.67902896
183Skin pits (HP:0100276)1.67567692
184Epiphyseal dysplasia (HP:0002656)1.67243974
185Sclerocornea (HP:0000647)1.67114378
186Short chin (HP:0000331)1.66796181
187Hyperkalemia (HP:0002153)1.65653194
188Spinal rigidity (HP:0003306)1.65253045
189Highly arched eyebrow (HP:0002553)1.64615252
190Blepharitis (HP:0000498)1.64581626
191Depressed nasal tip (HP:0000437)1.64174995
192Nasolacrimal duct obstruction (HP:0000579)1.63839409
193Cardiovascular calcification (HP:0011915)1.63637036

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R5.71629465
2ACVR1B4.56937633
3EPHB24.39678394
4MST44.35886585
5MAP3K34.30049337
6MAPKAPK33.89932678
7FER3.25828691
8LATS13.13510660
9TRPM72.88660818
10ERBB32.60768005
11AKT32.37052819
12MAP3K22.34202788
13MKNK22.27626964
14MET2.26626637
15PIM22.23752923
16ERN12.11621884
17EPHA31.92463885
18INSRR1.89724508
19LRRK21.88670836
20RPS6KB21.80221757
21ADRBK21.72444495
22LATS21.72195477
23TESK11.67958396
24BCR1.66314338
25PIK3CG1.64493323
26GRK11.54056826
27DDR21.48330944
28FRK1.44901384
29MAPKAPK51.42437615
30CAMK1D1.42103712
31CAMK1G1.40311752
32FGFR21.38107040
33BMPR1B1.33017030
34STK241.31280771
35TAOK31.28421752
36BRSK21.26099139
37BRD41.23356175
38WNK41.17243358
39OXSR11.16961139
40MAP3K41.15850260
41STK101.11969477
42ZAK1.09387398
43PIK3CA1.08352777
44CAMKK21.08117834
45MAPK131.07675775
46MELK1.07607192
47NME21.06748155
48SGK21.04561756
49CDK121.01722993
50STK390.98760456
51WNK30.97452196
52DYRK1B0.96663080
53LIMK10.95240600
54TNK20.94916219
55DAPK20.94556225
56MKNK10.94354860
57NLK0.94274270
58NTRK30.91195790
59TNIK0.91188060
60TGFBR10.90601530
61RPS6KA40.84486321
62MOS0.84427642
63NUAK10.83324526
64PRKAA20.81745837
65CASK0.78846043
66TGFBR20.77753798
67MAP3K70.76663479
68WNK10.76301934
69PAK30.74738650
70SIK20.74402988
71TLK10.73042850
72ERBB40.72456417
73FGFR40.72408996
74PTK2B0.72252600
75STK380.72107057
76PDGFRA0.69535031
77EEF2K0.69110026
78CDK30.68573816
79EPHA20.68146815
80RIPK40.68099859
81PRKCG0.67812893
82SGK2230.67185186
83SGK4940.67185186
84PNCK0.64869771
85PTK60.64173075
86CHUK0.64065167
87STK38L0.64010213
88PBK0.62425130
89EIF2AK20.62245137
90TTN0.62228314
91MAPKAPK20.61585220
92PRKCE0.61451823
93PINK10.61180412
94ROCK10.59598663
95STK110.58486883
96TEC0.57849307
97PRKD10.56911349
98FGFR30.55880957
99CDK60.55636066
100PDK20.55158500
101ADRBK10.54352627
102MARK10.53617296
103CAMK10.52925707
104IKBKB0.51223928
105NEK90.51071579
106TYK20.50976053
107CAMK40.50692177
108MAP3K10.50168124
109MAP3K140.49928206
110ERBB20.48544866
111MAPK120.47311848
112TAOK10.47159883
113NTRK20.46223104
114RPS6KA60.46202345
115PTK20.45357263
116SGK30.44486392
117OBSCN0.44202730
118KIT0.43635220
119PRKAA10.43488828
120NEK20.43470417
121PKN10.42311067
122STK30.41268601
123SGK10.41051416
124CAMK2A0.40548758
125GRK70.39501777
126ITK0.38873076
127CAMKK10.38844981
128IRAK10.38126728
129MAP3K110.37628772
130YES10.36984392
131FGFR10.36139406
132MAP2K70.35118782
133ABL10.34929463
134MAPK150.34203419
135MAPK110.32066216
136MAP2K10.31055982
137IKBKE0.31009308
138HIPK20.30006193
139BMPR20.29826601
140CSNK1D0.29688884
141MAP3K90.29653419
142PRKCH0.29133932
143AURKA0.28635266
144MAP2K60.28512173
145MAP3K60.28373268
146MAP2K40.26902447
147PAK20.26895468
148ILK0.26633809
149PLK40.26550002
150AURKB0.26146871
151RPS6KA30.25640743
152GSK3B0.24553701
153MTOR0.24534474
154IGF1R0.23529548
155MAP3K50.23472204
156PDGFRB0.22397244
157DYRK30.22307078
158BLK0.19702589
159SRC0.19103755
160TAOK20.18179983
161RPS6KA10.17836997
162DYRK1A0.17767550
163MAPK30.17095107
164MAPK70.16598540
165GRK50.16561178
166PRKCI0.16507660

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004605.57188376
2Ribosome_Homo sapiens_hsa030104.63370229
3Sphingolipid metabolism_Homo sapiens_hsa006003.86240829
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.38757973
5Nicotine addiction_Homo sapiens_hsa050332.44057640
6ABC transporters_Homo sapiens_hsa020102.40239182
7ECM-receptor interaction_Homo sapiens_hsa045122.39656489
8Arachidonic acid metabolism_Homo sapiens_hsa005902.37901655
9Nitrogen metabolism_Homo sapiens_hsa009102.33905240
10Linoleic acid metabolism_Homo sapiens_hsa005912.30727664
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.16975840
12Fatty acid elongation_Homo sapiens_hsa000622.00417246
13Phenylalanine metabolism_Homo sapiens_hsa003601.99660864
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.98894260
15Basal cell carcinoma_Homo sapiens_hsa052171.93504310
16Dorso-ventral axis formation_Homo sapiens_hsa043201.90182699
17Butanoate metabolism_Homo sapiens_hsa006501.83692759
18Taste transduction_Homo sapiens_hsa047421.82506943
19TGF-beta signaling pathway_Homo sapiens_hsa043501.76216248
20Adherens junction_Homo sapiens_hsa045201.75137616
21Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.74731121
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.68440043
23Tryptophan metabolism_Homo sapiens_hsa003801.67705585
24Retinol metabolism_Homo sapiens_hsa008301.66194216
25Chemical carcinogenesis_Homo sapiens_hsa052041.62392072
26Glutamatergic synapse_Homo sapiens_hsa047241.55444817
27Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.54735526
28Hippo signaling pathway_Homo sapiens_hsa043901.53839755
29Lysine degradation_Homo sapiens_hsa003101.51274220
30Morphine addiction_Homo sapiens_hsa050321.47247371
31Histidine metabolism_Homo sapiens_hsa003401.46156498
32Circadian rhythm_Homo sapiens_hsa047101.45969302
33Caffeine metabolism_Homo sapiens_hsa002321.45937703
34p53 signaling pathway_Homo sapiens_hsa041151.41286461
35Circadian entrainment_Homo sapiens_hsa047131.41253849
36Bladder cancer_Homo sapiens_hsa052191.40210652
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.39300990
38Selenocompound metabolism_Homo sapiens_hsa004501.37630200
39Proteoglycans in cancer_Homo sapiens_hsa052051.36967368
40Protein digestion and absorption_Homo sapiens_hsa049741.36348387
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.32713716
42Tight junction_Homo sapiens_hsa045301.31582687
43Axon guidance_Homo sapiens_hsa043601.25535915
44Hedgehog signaling pathway_Homo sapiens_hsa043401.24719211
45Ether lipid metabolism_Homo sapiens_hsa005651.21801723
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.20274238
47Homologous recombination_Homo sapiens_hsa034401.18580001
48Sphingolipid signaling pathway_Homo sapiens_hsa040711.17180177
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16761057
50GABAergic synapse_Homo sapiens_hsa047271.16060214
51Long-term depression_Homo sapiens_hsa047301.14881733
52Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14441374
53Glycerolipid metabolism_Homo sapiens_hsa005611.13279133
54MicroRNAs in cancer_Homo sapiens_hsa052061.13181246
55Salivary secretion_Homo sapiens_hsa049701.13026518
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.11199291
57Olfactory transduction_Homo sapiens_hsa047401.10670619
58Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.08253773
59Insulin secretion_Homo sapiens_hsa049111.06986847
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06409920
61Leukocyte transendothelial migration_Homo sapiens_hsa046701.05716257
62Glutathione metabolism_Homo sapiens_hsa004801.05530030
63Melanogenesis_Homo sapiens_hsa049161.03797526
64Amoebiasis_Homo sapiens_hsa051461.02705923
65Fanconi anemia pathway_Homo sapiens_hsa034601.00563975
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00439464
67Tyrosine metabolism_Homo sapiens_hsa003500.98513936
68Oxytocin signaling pathway_Homo sapiens_hsa049210.96953412
69Gastric acid secretion_Homo sapiens_hsa049710.95962718
70Malaria_Homo sapiens_hsa051440.95868484
71Focal adhesion_Homo sapiens_hsa045100.95633263
72Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.92276561
73Melanoma_Homo sapiens_hsa052180.90770773
74cAMP signaling pathway_Homo sapiens_hsa040240.87491530
75Wnt signaling pathway_Homo sapiens_hsa043100.86588902
76Cholinergic synapse_Homo sapiens_hsa047250.86314551
77Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85665862
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.79863067
79Type II diabetes mellitus_Homo sapiens_hsa049300.79305623
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76380012
81Ras signaling pathway_Homo sapiens_hsa040140.75732218
82Thyroid cancer_Homo sapiens_hsa052160.74936755
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.74556178
84Mineral absorption_Homo sapiens_hsa049780.73794263
85FoxO signaling pathway_Homo sapiens_hsa040680.73133422
86Glycerophospholipid metabolism_Homo sapiens_hsa005640.72266828
87Dopaminergic synapse_Homo sapiens_hsa047280.72151571
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71790909
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.71564127
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71021017
91Rap1 signaling pathway_Homo sapiens_hsa040150.69444202
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68863235
93Choline metabolism in cancer_Homo sapiens_hsa052310.67605587
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67128406
95VEGF signaling pathway_Homo sapiens_hsa043700.66324546
96Phototransduction_Homo sapiens_hsa047440.65797476
97Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64907441
98Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.63030230
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.62801206
100Pancreatic secretion_Homo sapiens_hsa049720.62600456
101Ovarian steroidogenesis_Homo sapiens_hsa049130.62134505
102Pertussis_Homo sapiens_hsa051330.61887984
103PI3K-Akt signaling pathway_Homo sapiens_hsa041510.61516683
104GnRH signaling pathway_Homo sapiens_hsa049120.61309143
105Prostate cancer_Homo sapiens_hsa052150.61247272
106Hepatitis C_Homo sapiens_hsa051600.59727066
107Bile secretion_Homo sapiens_hsa049760.58481700
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57433965
109Fatty acid biosynthesis_Homo sapiens_hsa000610.57247628
110Renin secretion_Homo sapiens_hsa049240.56811227
111MAPK signaling pathway_Homo sapiens_hsa040100.56748097
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.56679407
113Platelet activation_Homo sapiens_hsa046110.56045689
114Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55627761
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.54533089
116Pathways in cancer_Homo sapiens_hsa052000.53858022
117Small cell lung cancer_Homo sapiens_hsa052220.52800862
118Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52374773
119Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.51939398
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51498398
121Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50459529
122Cocaine addiction_Homo sapiens_hsa050300.49180212
123Phospholipase D signaling pathway_Homo sapiens_hsa040720.48836141
124Steroid hormone biosynthesis_Homo sapiens_hsa001400.48147570
125SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46517656
126Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46073557
127Serotonergic synapse_Homo sapiens_hsa047260.45909630
128Staphylococcus aureus infection_Homo sapiens_hsa051500.44232603
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.43787436
130Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42568698
131Basal transcription factors_Homo sapiens_hsa030220.41831346
132Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.40468936
133Graft-versus-host disease_Homo sapiens_hsa053320.39044970
134Amphetamine addiction_Homo sapiens_hsa050310.38379498
135Insulin resistance_Homo sapiens_hsa049310.38234197
136Vibrio cholerae infection_Homo sapiens_hsa051100.37835978
137Toxoplasmosis_Homo sapiens_hsa051450.36924765
138TNF signaling pathway_Homo sapiens_hsa046680.36363799
139beta-Alanine metabolism_Homo sapiens_hsa004100.34753405
140Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34660977
141Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.34491680
142Endometrial cancer_Homo sapiens_hsa052130.32320398
143ErbB signaling pathway_Homo sapiens_hsa040120.30489805
144Hematopoietic cell lineage_Homo sapiens_hsa046400.30045936
145Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.28181941
146Fat digestion and absorption_Homo sapiens_hsa049750.26846222
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.26679008
148Phagosome_Homo sapiens_hsa041450.26496266
149HTLV-I infection_Homo sapiens_hsa051660.24666447
150Salmonella infection_Homo sapiens_hsa051320.23995540
151NOD-like receptor signaling pathway_Homo sapiens_hsa046210.23923394
152Dilated cardiomyopathy_Homo sapiens_hsa054140.23629297
153Endocytosis_Homo sapiens_hsa041440.20515135
154Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20323976
155Folate biosynthesis_Homo sapiens_hsa007900.20316911
156Rheumatoid arthritis_Homo sapiens_hsa053230.20147523
157Calcium signaling pathway_Homo sapiens_hsa040200.18749519
158Complement and coagulation cascades_Homo sapiens_hsa046100.18593394
159Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.18432689

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