TMEM41B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)7.29214158
2ribosome assembly (GO:0042255)6.38453480
3nucleobase biosynthetic process (GO:0046112)6.22241413
4vitamin transmembrane transport (GO:0035461)5.83055361
5proteasome assembly (GO:0043248)5.62058694
6folic acid metabolic process (GO:0046655)5.31009687
7mitotic metaphase plate congression (GO:0007080)5.19303438
8folic acid transport (GO:0015884)5.17539948
9rRNA modification (GO:0000154)4.74742559
10ribosome biogenesis (GO:0042254)4.71099354
11lung-associated mesenchyme development (GO:0060484)4.66357224
12regulation of spindle organization (GO:0090224)4.64719717
13regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.63948655
14pantothenate metabolic process (GO:0015939)4.63543696
15termination of RNA polymerase III transcription (GO:0006386)4.52074560
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.52074560
17anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.45941571
18L-methionine biosynthetic process (GO:0071265)4.41970442
19amino acid salvage (GO:0043102)4.41970442
20L-methionine salvage (GO:0071267)4.41970442
21positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.41185316
22DNA double-strand break processing (GO:0000729)4.35461017
23regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.34220546
24GMP metabolic process (GO:0046037)4.30722246
25blastocyst development (GO:0001824)4.25671962
26intestinal epithelial cell development (GO:0060576)4.25454335
27transcription elongation from RNA polymerase I promoter (GO:0006362)4.23599750
28negative regulation of DNA-dependent DNA replication (GO:2000104)4.19852321
29negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.19631346
30DNA replication checkpoint (GO:0000076)4.18354282
31termination of RNA polymerase I transcription (GO:0006363)4.18059422
327-methylguanosine mRNA capping (GO:0006370)4.13405585
33DNA deamination (GO:0045006)4.03007079
34transcription from RNA polymerase I promoter (GO:0006360)4.02916855
357-methylguanosine RNA capping (GO:0009452)3.99275925
36RNA capping (GO:0036260)3.99275925
37regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.96222225
38positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.96133740
39metaphase plate congression (GO:0051310)3.87167688
40autophagic vacuole assembly (GO:0000045)3.83669901
41water-soluble vitamin biosynthetic process (GO:0042364)3.83402551
42CDP-diacylglycerol metabolic process (GO:0046341)3.81907353
43regulation of translation in response to stress (GO:0043555)3.81508074
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.75894120
45negative regulation of ligase activity (GO:0051352)3.75894120
46transcription initiation from RNA polymerase I promoter (GO:0006361)3.74563502
47positive regulation of ligase activity (GO:0051351)3.71089479
48replication fork processing (GO:0031297)3.70204017
49positive regulation of chromosome segregation (GO:0051984)3.68261029
50protein K6-linked ubiquitination (GO:0085020)3.66463846
51methionine biosynthetic process (GO:0009086)3.65128653
52regulation of cellular amino acid metabolic process (GO:0006521)3.63197135
53regulation of mitotic spindle organization (GO:0060236)3.60586843
54spindle checkpoint (GO:0031577)3.57455390
55S-adenosylmethionine metabolic process (GO:0046500)3.56569422
56maturation of 5.8S rRNA (GO:0000460)3.54084360
57NADH metabolic process (GO:0006734)3.53973368
58rRNA methylation (GO:0031167)3.50103870
59ribonucleoprotein complex biogenesis (GO:0022613)3.49143298
60modified amino acid transport (GO:0072337)3.48205240
61mitotic spindle checkpoint (GO:0071174)3.47593040
62regulation of ubiquitin-protein transferase activity (GO:0051438)3.44691419
63histone-serine phosphorylation (GO:0035404)3.43090547
64cullin deneddylation (GO:0010388)3.42730789
65regulation of mitochondrial translation (GO:0070129)3.41823583
66formation of translation preinitiation complex (GO:0001731)3.41646660
67respiratory chain complex IV assembly (GO:0008535)3.40345590
68maturation of SSU-rRNA (GO:0030490)3.40292937
69methionine metabolic process (GO:0006555)3.39250726
70rRNA processing (GO:0006364)3.37859665
71chromatin remodeling at centromere (GO:0031055)3.34648852
72regulation of G0 to G1 transition (GO:0070316)3.33749435
73L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.33604285
74guanosine-containing compound biosynthetic process (GO:1901070)3.32344979
75meiosis I (GO:0007127)3.32279625
76transcription elongation from RNA polymerase II promoter (GO:0006368)3.31974700
77DNA-templated transcription, elongation (GO:0006354)3.30824392
78regulation of nuclear cell cycle DNA replication (GO:0033262)3.28872039
79somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.28050106
80isotype switching (GO:0045190)3.28050106
81somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.28050106
82mitotic spindle assembly checkpoint (GO:0007094)3.27683751
83rRNA metabolic process (GO:0016072)3.27380228
84synapsis (GO:0007129)3.27037474
85spliceosomal snRNP assembly (GO:0000387)3.27022932
86negative regulation of chromosome segregation (GO:0051985)3.26891861
87negative regulation of mitotic sister chromatid separation (GO:2000816)3.26450178
88negative regulation of mitotic sister chromatid segregation (GO:0033048)3.26450178
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.26450178
90negative regulation of sister chromatid segregation (GO:0033046)3.26450178
91regulation of ligase activity (GO:0051340)3.25853949
92regulation of chromosome segregation (GO:0051983)3.24765898
93cofactor transport (GO:0051181)3.22390519
94platelet dense granule organization (GO:0060155)3.21908419
95positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)3.19839358
96signal transduction involved in DNA integrity checkpoint (GO:0072401)3.19716352
97signal transduction involved in DNA damage checkpoint (GO:0072422)3.19716352
98glycine metabolic process (GO:0006544)3.19334983
99spindle assembly checkpoint (GO:0071173)3.17952060
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.17669078
101signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.17669078
102signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.17669078
103CENP-A containing nucleosome assembly (GO:0034080)3.17417900
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.17103169
105lactate metabolic process (GO:0006089)3.15104723
106signal transduction involved in cell cycle checkpoint (GO:0072395)3.14138846
107histone exchange (GO:0043486)3.12729835
108regulation of mitotic spindle checkpoint (GO:1903504)3.12644391
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.12644391
110G1/S transition of mitotic cell cycle (GO:0000082)3.12498103
111cell cycle G1/S phase transition (GO:0044843)3.12498103
112protein deneddylation (GO:0000338)3.11754794
113positive regulation of viral transcription (GO:0050434)3.11416066
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.10475919
115regulation of translational termination (GO:0006449)3.10244845
116regulation of exit from mitosis (GO:0007096)3.07612764
117regulation of mitotic metaphase/anaphase transition (GO:0030071)3.06874858
118sulfur amino acid biosynthetic process (GO:0000097)3.06774336
119regulation of hexokinase activity (GO:1903299)3.06727530
120regulation of glucokinase activity (GO:0033131)3.06727530
121signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.05112331
122intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.05112331
123response to pheromone (GO:0019236)3.01456368
124regulation of mesoderm development (GO:2000380)3.01176357
125regulation of DNA endoreduplication (GO:0032875)3.00879014
126positive regulation of protein autophosphorylation (GO:0031954)2.96213487
127anterior/posterior axis specification, embryo (GO:0008595)2.93922559
128RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.93182357
129regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.90362442
130keratinocyte development (GO:0003334)2.90307114
131maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.89101555
132negative regulation of DNA recombination (GO:0045910)2.84151060
133regulation of centriole replication (GO:0046599)2.84040217
134fucose catabolic process (GO:0019317)2.81993519
135L-fucose metabolic process (GO:0042354)2.81993519
136L-fucose catabolic process (GO:0042355)2.81993519
137somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81028811
138somatic hypermutation of immunoglobulin genes (GO:0016446)2.81028811
139female gonad development (GO:0008585)2.80075125
140double-strand break repair via homologous recombination (GO:0000724)2.76931639
141recombinational repair (GO:0000725)2.76784332
142regulation of meiosis I (GO:0060631)2.73335183
143negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.73001830
144negative regulation of translation, ncRNA-mediated (GO:0040033)2.73001830
145regulation of translation, ncRNA-mediated (GO:0045974)2.73001830
146regulation of acyl-CoA biosynthetic process (GO:0050812)2.71803838
147branched-chain amino acid catabolic process (GO:0009083)2.70229462
148exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68184815
149nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66116916
150cytochrome complex assembly (GO:0017004)2.65550809
151prenylation (GO:0097354)2.63473309
152protein prenylation (GO:0018342)2.63473309
153limb bud formation (GO:0060174)2.63471298
154cholesterol biosynthetic process (GO:0006695)2.62049608
155dorsal/ventral axis specification (GO:0009950)2.62021762
156regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.61070169
157DNA catabolic process, exonucleolytic (GO:0000738)2.60996388
158kidney morphogenesis (GO:0060993)2.60888513
159positive regulation of glycoprotein biosynthetic process (GO:0010560)2.60498528
160telomere maintenance via telomerase (GO:0007004)2.58310823
161regulation of sulfur metabolic process (GO:0042762)2.57621420
162mitotic sister chromatid cohesion (GO:0007064)2.57299897
163response to X-ray (GO:0010165)2.56926642
164somite rostral/caudal axis specification (GO:0032525)2.55748063
165sterol biosynthetic process (GO:0016126)2.54526611
166DNA replication-dependent nucleosome assembly (GO:0006335)2.53481372
167DNA replication-dependent nucleosome organization (GO:0034723)2.53481372
168signal peptide processing (GO:0006465)2.52645805
169lysine catabolic process (GO:0006554)2.52482966
170lysine metabolic process (GO:0006553)2.52482966
171regulation of helicase activity (GO:0051095)2.52463992
172single strand break repair (GO:0000012)2.51589144
173somatic recombination of immunoglobulin gene segments (GO:0016447)2.49381710
174DNA strand renaturation (GO:0000733)2.48067484
175regulation of coenzyme metabolic process (GO:0051196)2.47314227
176regulation of cofactor metabolic process (GO:0051193)2.47314227
177regulation of Rac protein signal transduction (GO:0035020)2.47200933
178peptidyl-histidine modification (GO:0018202)2.46376584
179somatic diversification of immunoglobulins (GO:0016445)2.45319658
180postreplication repair (GO:0006301)2.44946325
181intra-S DNA damage checkpoint (GO:0031573)2.44155250
182protein neddylation (GO:0045116)2.44154864
183centriole replication (GO:0007099)2.43638361
184fatty acid elongation (GO:0030497)2.43011472
185reciprocal DNA recombination (GO:0035825)2.41171838
186reciprocal meiotic recombination (GO:0007131)2.41171838
187histone H2A acetylation (GO:0043968)2.40896916
188nodal signaling pathway (GO:0038092)2.37598857
189atrial cardiac muscle cell action potential (GO:0086014)2.37057022
190peptidyl-cysteine modification (GO:0018198)2.35890223
191detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.35836280
192establishment of protein localization to mitochondrial membrane (GO:0090151)2.31936549
193non-recombinational repair (GO:0000726)2.30758413
194double-strand break repair via nonhomologous end joining (GO:0006303)2.30758413
195inositol phosphate catabolic process (GO:0071545)2.30704322
196presynaptic membrane assembly (GO:0097105)2.30240738
197neural tube formation (GO:0001841)2.27300665

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.30502128
2E2F7_22180533_ChIP-Seq_HELA_Human4.35000020
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.13226332
4* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.97189254
5CREB1_15753290_ChIP-ChIP_HEK293T_Human3.87912886
6ETS1_20019798_ChIP-Seq_JURKAT_Human3.84407501
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.75697197
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.63160518
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.43699390
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.28045838
11CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.25276330
12MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.08619691
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.87606431
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87345896
15ZNF274_21170338_ChIP-Seq_K562_Hela2.87274986
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.85091519
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81789363
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.72219129
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70515014
20E2F4_17652178_ChIP-ChIP_JURKAT_Human2.59777790
21VDR_23849224_ChIP-Seq_CD4+_Human2.59032084
22AR_21909140_ChIP-Seq_LNCAP_Human2.56452783
23VDR_22108803_ChIP-Seq_LS180_Human2.54087267
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51585666
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39489151
26FUS_26573619_Chip-Seq_HEK293_Human2.38250367
27FLI1_27457419_Chip-Seq_LIVER_Mouse2.37624733
28ZFP57_27257070_Chip-Seq_ESCs_Mouse2.31387239
29GBX2_23144817_ChIP-Seq_PC3_Human2.29354425
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.29322016
31EWS_26573619_Chip-Seq_HEK293_Human2.27984328
32NANOG_18555785_ChIP-Seq_MESCs_Mouse2.27196191
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.27059105
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.23882550
35CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18955963
36P300_19829295_ChIP-Seq_ESCs_Human2.15037330
37IGF1R_20145208_ChIP-Seq_DFB_Human2.13181717
38* GABP_19822575_ChIP-Seq_HepG2_Human2.10406604
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09960167
40TAF15_26573619_Chip-Seq_HEK293_Human2.09153461
41E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08682756
42XRN2_22483619_ChIP-Seq_HELA_Human2.07939928
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02929190
44ZNF263_19887448_ChIP-Seq_K562_Human2.01981060
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.93842563
46DCP1A_22483619_ChIP-Seq_HELA_Human1.91400091
47* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91205172
48FOXP3_21729870_ChIP-Seq_TREG_Human1.86955525
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.83286617
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.82163348
51THAP11_20581084_ChIP-Seq_MESCs_Mouse1.80035067
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71601787
53HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.70366906
54* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.67878129
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65343556
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63747849
57KDM5A_27292631_Chip-Seq_BREAST_Human1.62520608
58* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60388005
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58276827
60SRF_21415370_ChIP-Seq_HL-1_Mouse1.57047227
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53462830
62* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53447035
63* TTF2_22483619_ChIP-Seq_HELA_Human1.50844965
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.49596152
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.48889624
66CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48369790
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48236354
68BCAT_22108803_ChIP-Seq_LS180_Human1.46645331
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.46369661
70MYC_18940864_ChIP-ChIP_HL60_Human1.46120409
71ER_23166858_ChIP-Seq_MCF-7_Human1.44725572
72MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.40719527
73* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39969750
74* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.39385017
75FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.38655777
76ELK1_19687146_ChIP-ChIP_HELA_Human1.38084061
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35838058
78SMAD4_21799915_ChIP-Seq_A2780_Human1.35533717
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.34857489
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.33685831
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.32030978
82* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31821336
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.30275570
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.29868337
85SOX2_19829295_ChIP-Seq_ESCs_Human1.29839908
86NANOG_19829295_ChIP-Seq_ESCs_Human1.29839908
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29262871
88NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.29121306
89ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.28662874
90EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.27864537
91GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.26533655
92NFE2_27457419_Chip-Seq_LIVER_Mouse1.26296726
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.25833407
94KAP1_22055183_ChIP-Seq_ESCs_Mouse1.25019503
95IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25003112
96CBP_20019798_ChIP-Seq_JUKART_Human1.25003112
97NANOG_16153702_ChIP-ChIP_HESCs_Human1.24237899
98PCGF2_27294783_Chip-Seq_NPCs_Mouse1.23709155
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.23573807
100PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22710739
101* E2F1_21310950_ChIP-Seq_MCF-7_Human1.22478415
102STAT3_1855785_ChIP-Seq_MESCs_Mouse1.22298020
103* STAT3_23295773_ChIP-Seq_U87_Human1.21851985
104TCF4_22108803_ChIP-Seq_LS180_Human1.20149425
105SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.20072567
106AR_25329375_ChIP-Seq_VCAP_Human1.19007371
107ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17806598
108HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.17689584
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.17299891
110ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17202853
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17015277
112* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16860139
113TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.16056504
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15931166
115CDX2_22108803_ChIP-Seq_LS180_Human1.15304999
116CIITA_25753668_ChIP-Seq_RAJI_Human1.15059670
117* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.14673144
118MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14651129
119CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14578785
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.13909726
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.13901961
122TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13802934
123CRX_20693478_ChIP-Seq_RETINA_Mouse1.13051625
124POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.12283774
125BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11861194
126* TCF4_23295773_ChIP-Seq_U87_Human1.11682824
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.10733408
128* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.10304160
129FOXM1_26456572_ChIP-Seq_MCF-7_Human1.08310693
130EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07845653
131SMAD4_21741376_ChIP-Seq_EPCs_Human1.07814361
132DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06608198
133P53_22387025_ChIP-Seq_ESCs_Mouse1.06562601
134NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.06241777
135TP53_22573176_ChIP-Seq_HFKS_Human1.04539284
136* TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.03744776
137RBPJ_22232070_ChIP-Seq_NCS_Mouse1.02725250
138RUNX2_22187159_ChIP-Seq_PCA_Human1.01635326
139HOXB4_20404135_ChIP-ChIP_EML_Mouse1.00618384
140SUZ12_18555785_Chip-Seq_ESCs_Mouse1.00315443
141PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00191534
142SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99854589
143SOX2_16153702_ChIP-ChIP_HESCs_Human0.99396599
144P300_18555785_Chip-Seq_ESCs_Mouse0.98678997
145FOXA1_21572438_ChIP-Seq_LNCaP_Human0.98645705
146NANOG_21062744_ChIP-ChIP_HESCs_Human0.98363666
147STAT3_18555785_Chip-Seq_ESCs_Mouse0.98296411
148NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98256031
149FOXA1_25329375_ChIP-Seq_VCAP_Human0.98245901
150FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98245901
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.97841977
152SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.97714549
153* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96301624
154NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95573178
155SOX17_20123909_ChIP-Seq_XEN_Mouse0.95259643
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.94517446
157SOX2_18692474_ChIP-Seq_MEFs_Mouse0.93853163
158NOTCH1_21737748_ChIP-Seq_TLL_Human0.92221073
159CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.91802769
160* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91506833
161TFEB_21752829_ChIP-Seq_HELA_Human0.90228964
162CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89914820
163OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89076097
164SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88806088
165CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.88242623
166NANOG_18692474_ChIP-Seq_MEFs_Mouse0.87917002
167SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.87831233
168CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.86309144
169POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85059530
170KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84893284
171KAP1_27257070_Chip-Seq_ESCs_Mouse0.83497879
172POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82726188
173TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81825845
174TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.81332230
175* CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.80115092

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.73510562
2MP0003718_maternal_effect5.20258332
3MP0003111_abnormal_nucleus_morphology4.97803949
4MP0008260_abnormal_autophagy4.62016412
5MP0009840_abnormal_foam_cell4.02693001
6MP0004957_abnormal_blastocyst_morpholog3.99417153
7MP0003195_calcinosis3.83283371
8MP0010094_abnormal_chromosome_stability3.34722324
9MP0003077_abnormal_cell_cycle3.27531782
10MP0003890_abnormal_embryonic-extraembry3.06557490
11MP0003786_premature_aging2.87004832
12MP0005377_hearing/vestibular/ear_phenot2.80733810
13MP0003878_abnormal_ear_physiology2.80733810
14MP0008058_abnormal_DNA_repair2.51927117
15MP0003787_abnormal_imprinting2.44669765
16MP0008932_abnormal_embryonic_tissue2.43365267
17MP0000372_irregular_coat_pigmentation2.39080739
18MP0001661_extended_life_span2.35259628
19MP0008057_abnormal_DNA_replication2.29289830
20MP0001542_abnormal_bone_strength2.27495461
21MP0002938_white_spotting2.24118673
22MP0003123_paternal_imprinting2.20841837
23MP0001730_embryonic_growth_arrest2.18320231
24MP0005395_other_phenotype2.08123341
25MP0005451_abnormal_body_composition2.00854057
26MP0000516_abnormal_urinary_system1.99963375
27MP0005367_renal/urinary_system_phenotyp1.99963375
28MP0003121_genomic_imprinting1.87675104
29MP0003315_abnormal_perineum_morphology1.85676016
30MP0006072_abnormal_retinal_apoptosis1.85637508
31MP0008007_abnormal_cellular_replicative1.82179963
32MP0003119_abnormal_digestive_system1.77704620
33MP0002837_dystrophic_cardiac_calcinosis1.77055422
34MP0008877_abnormal_DNA_methylation1.74840950
35MP0006054_spinal_hemorrhage1.74695651
36MP0005380_embryogenesis_phenotype1.66700592
37MP0001672_abnormal_embryogenesis/_devel1.66700592
38MP0005551_abnormal_eye_electrophysiolog1.65928813
39MP0000350_abnormal_cell_proliferation1.58660057
40MP0000427_abnormal_hair_cycle1.57706932
41MP0001485_abnormal_pinna_reflex1.49434527
42MP0005253_abnormal_eye_physiology1.49191602
43MP0009333_abnormal_splenocyte_physiolog1.48668615
44MP0002254_reproductive_system_inflammat1.47513352
45MP0004019_abnormal_vitamin_homeostasis1.47456355
46MP0001984_abnormal_olfaction1.46200289
47MP0003221_abnormal_cardiomyocyte_apopto1.44908394
48MP0004147_increased_porphyrin_level1.44745321
49MP0009697_abnormal_copulation1.44225611
50MP0006292_abnormal_olfactory_placode1.43883905
51MP0005058_abnormal_lysosome_morphology1.43238705
52MP0003984_embryonic_growth_retardation1.40441235
53MP0002080_prenatal_lethality1.38849657
54MP0001756_abnormal_urination1.38626843
55MP0002088_abnormal_embryonic_growth/wei1.37749003
56MP0003938_abnormal_ear_development1.36961443
57MP0004133_heterotaxia1.36759058
58MP0010234_abnormal_vibrissa_follicle1.35036376
59MP0002210_abnormal_sex_determination1.34964769
60MP0003567_abnormal_fetal_cardiomyocyte1.34914104
61MP0000750_abnormal_muscle_regeneration1.34719652
62MP0003122_maternal_imprinting1.31899100
63MP0001697_abnormal_embryo_size1.30777875
64MP0002751_abnormal_autonomic_nervous1.29716308
65MP0000569_abnormal_digit_pigmentation1.27605824
66MP0002234_abnormal_pharynx_morphology1.25233415
67MP0003283_abnormal_digestive_organ1.24683647
68MP0003941_abnormal_skin_development1.23991352
69MP0001188_hyperpigmentation1.23560454
70MP0002736_abnormal_nociception_after1.22381929
71MP0003880_abnormal_central_pattern1.22066248
72MP0010307_abnormal_tumor_latency1.21264536
73MP0004215_abnormal_myocardial_fiber1.21057091
74MP0005174_abnormal_tail_pigmentation1.20033250
75MP0001145_abnormal_male_reproductive1.19235438
76MP0001324_abnormal_eye_pigmentation1.18050436
77MP0001929_abnormal_gametogenesis1.17571718
78MP0002090_abnormal_vision1.16456561
79MP0005084_abnormal_gallbladder_morpholo1.13904955
80MP0000647_abnormal_sebaceous_gland1.13264270
81MP0001529_abnormal_vocalization1.10785738
82MP0004885_abnormal_endolymph1.10557618
83MP0008872_abnormal_physiological_respon1.09987347
84MP0004084_abnormal_cardiac_muscle1.06469600
85MP0002085_abnormal_embryonic_tissue1.06147372
86MP0000358_abnormal_cell_content/1.06136054
87MP0005332_abnormal_amino_acid1.05658086
88MP0000653_abnormal_sex_gland1.05212315
89MP0003329_amyloid_beta_deposits1.04728971
90MP0005075_abnormal_melanosome_morpholog1.04663280
91MP0000383_abnormal_hair_follicle1.01337113
92MP0005389_reproductive_system_phenotype0.99880400
93MP0000631_abnormal_neuroendocrine_gland0.99541791
94MP0003937_abnormal_limbs/digits/tail_de0.99343492
95MP0003656_abnormal_erythrocyte_physiolo0.97917830
96MP0000747_muscle_weakness0.97185456
97MP0009672_abnormal_birth_weight0.97105280
98MP0003011_delayed_dark_adaptation0.96142413
99MP0003806_abnormal_nucleotide_metabolis0.95684618
100MP0002233_abnormal_nose_morphology0.95657988
101MP0003646_muscle_fatigue0.95574995
102MP0002638_abnormal_pupillary_reflex0.95541733
103MP0008775_abnormal_heart_ventricle0.94723521
104MP0000627_abnormal_mammary_gland0.93982432
105MP0001286_abnormal_eye_development0.93733078
106MP0006035_abnormal_mitochondrial_morpho0.93328269
107MP0004043_abnormal_pH_regulation0.91822894
108MP0003950_abnormal_plasma_membrane0.91303251
109MP0005621_abnormal_cell_physiology0.90750178
110MP0000313_abnormal_cell_death0.90493641
111MP0002160_abnormal_reproductive_system0.90370951
112MP0009046_muscle_twitch0.90248063
113MP0005220_abnormal_exocrine_pancreas0.89423554
114MP0003699_abnormal_female_reproductive0.89352137
115MP0005379_endocrine/exocrine_gland_phen0.88582786
116MP0002396_abnormal_hematopoietic_system0.88283199
117MP0005384_cellular_phenotype0.88013377
118MP0000428_abnormal_craniofacial_morphol0.87449020
119MP0005171_absent_coat_pigmentation0.86859053
120MP0002086_abnormal_extraembryonic_tissu0.86653951
121MP0002282_abnormal_trachea_morphology0.86641728
122MP0005646_abnormal_pituitary_gland0.86085496
123MP0002102_abnormal_ear_morphology0.85150721
124MP0005248_abnormal_Harderian_gland0.84899789
125MP0001764_abnormal_homeostasis0.83834546
126MP0008995_early_reproductive_senescence0.83507474
127MP0001486_abnormal_startle_reflex0.82485113
128MP0001986_abnormal_taste_sensitivity0.81774181
129MP0002084_abnormal_developmental_patter0.80599571
130MP0000015_abnormal_ear_pigmentation0.80398103
131MP0008875_abnormal_xenobiotic_pharmacok0.78909887
132MP0003755_abnormal_palate_morphology0.77513548
133MP0001727_abnormal_embryo_implantation0.76410065
134MP0003943_abnormal_hepatobiliary_system0.75648564
135MP0005195_abnormal_posterior_eye0.75006813
136MP0002161_abnormal_fertility/fecundity0.74984106
137MP0003137_abnormal_impulse_conducting0.74648570
138MP0002163_abnormal_gland_morphology0.74565202
139MP0002132_abnormal_respiratory_system0.71279215
140MP0001919_abnormal_reproductive_system0.70393644
141MP0002653_abnormal_ependyma_morphology0.69013786
142MP0003879_abnormal_hair_cell0.68445820
143MP0003698_abnormal_male_reproductive0.68103966
144MP0001293_anophthalmia0.67753340
145MP0001119_abnormal_female_reproductive0.66606488
146MP0002269_muscular_atrophy0.64036322
147MP0003936_abnormal_reproductive_system0.63611532
148MP0003186_abnormal_redox_activity0.61756588
149MP0010678_abnormal_skin_adnexa0.60276792
150MP0000377_abnormal_hair_follicle0.59495321
151MP0004381_abnormal_hair_follicle0.58605632
152MP0005397_hematopoietic_system_phenotyp0.58314178
153MP0001545_abnormal_hematopoietic_system0.58314178
154MP0006036_abnormal_mitochondrial_physio0.57933584
155MP0009703_decreased_birth_body0.57155913
156MP0002092_abnormal_eye_morphology0.56010330
157MP0003136_yellow_coat_color0.55900155
158MP0000537_abnormal_urethra_morphology0.54729616
159MP0002876_abnormal_thyroid_physiology0.53913390
160MP0002019_abnormal_tumor_incidence0.53054980
161MP0002111_abnormal_tail_morphology0.52091566
162MP0005408_hypopigmentation0.50585577
163MP0004264_abnormal_extraembryonic_tissu0.49905851

Predicted human phenotypes

RankGene SetZ-score
1Breast hypoplasia (HP:0003187)5.56387639
2Cerebral hypomyelination (HP:0006808)5.05187693
3Birth length less than 3rd percentile (HP:0003561)5.03291070
4Carpal bone hypoplasia (HP:0001498)4.95232766
5Hyperglycinemia (HP:0002154)4.68612100
6Rough bone trabeculation (HP:0100670)4.36457710
7Gout (HP:0001997)4.09611587
8Impulsivity (HP:0100710)3.94250136
9Abnormality of the umbilical cord (HP:0010881)3.93105814
10Hyperglycinuria (HP:0003108)3.91119675
11Entropion (HP:0000621)3.73371381
12Ureteral duplication (HP:0000073)3.65957024
13Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.58396286
14Progressive muscle weakness (HP:0003323)3.55964072
15Aplasia/Hypoplasia of the patella (HP:0006498)3.40436815
16Abnormality of glycine metabolism (HP:0010895)3.32781558
17Abnormality of serine family amino acid metabolism (HP:0010894)3.32781558
18Aplasia/Hypoplasia involving the musculature (HP:0001460)3.30254355
19Patellar aplasia (HP:0006443)3.29050829
20Abnormal trabecular bone morphology (HP:0100671)3.26943438
21Premature rupture of membranes (HP:0001788)3.19899533
22CNS hypomyelination (HP:0003429)3.19802806
23Secondary amenorrhea (HP:0000869)3.17380602
24Pancreatic cysts (HP:0001737)3.16744872
25Abnormality of the distal phalanges of the toes (HP:0010182)3.15899205
26Abnormality of alanine metabolism (HP:0010916)3.15165773
27Hyperalaninemia (HP:0003348)3.15165773
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.15165773
29Bundle branch block (HP:0011710)3.14010261
30Tetraplegia (HP:0002445)3.13299798
31Atrioventricular block (HP:0001678)3.10051893
32Intestinal atresia (HP:0011100)3.09542026
33Irregular epiphyses (HP:0010582)3.01946149
34Abnormality of serum amino acid levels (HP:0003112)2.98989336
35Premature ovarian failure (HP:0008209)2.96412564
36Short nail (HP:0001799)2.90585862
37Pustule (HP:0200039)2.87811716
38Absent radius (HP:0003974)2.86730111
39Pancreatic islet-cell hyperplasia (HP:0004510)2.86549456
40Muscle fiber splitting (HP:0003555)2.85263402
41Ventricular fibrillation (HP:0001663)2.84200322
42Megaloblastic anemia (HP:0001889)2.82539175
43Segmental peripheral demyelination/remyelination (HP:0003481)2.81948078
44Death in infancy (HP:0001522)2.81771085
45Prolonged neonatal jaundice (HP:0006579)2.79992172
46True hermaphroditism (HP:0010459)2.79795562
47Glucose intolerance (HP:0000833)2.78251017
48Aplasia involving forearm bones (HP:0009822)2.72664156
49Absent forearm bone (HP:0003953)2.72664156
50Hypothermia (HP:0002045)2.71276884
51Methylmalonic acidemia (HP:0002912)2.71178586
52Molar tooth sign on MRI (HP:0002419)2.67990708
53Abnormality of midbrain morphology (HP:0002418)2.67990708
54Submucous cleft hard palate (HP:0000176)2.65526431
55Areflexia of lower limbs (HP:0002522)2.65137516
56Hypoplasia of the capital femoral epiphysis (HP:0003090)2.65061497
57Neoplasm of the adrenal cortex (HP:0100641)2.63675031
58Abnormal spermatogenesis (HP:0008669)2.63658297
59Delusions (HP:0000746)2.63633016
60Colon cancer (HP:0003003)2.61509391
61Congenital, generalized hypertrichosis (HP:0004540)2.60845216
62Abnormalities of placenta or umbilical cord (HP:0001194)2.59674109
63Multiple enchondromatosis (HP:0005701)2.59596710
64Degeneration of anterior horn cells (HP:0002398)2.58872871
65Abnormality of the anterior horn cell (HP:0006802)2.58872871
66Stillbirth (HP:0003826)2.56218140
67Sparse eyelashes (HP:0000653)2.54163396
68Sparse lateral eyebrow (HP:0005338)2.53411470
69Personality changes (HP:0000751)2.52646403
70Small epiphyses (HP:0010585)2.51637208
71Osteolytic defects of the hand bones (HP:0009699)2.51276066
72Osteolytic defects of the phalanges of the hand (HP:0009771)2.51276066
73Abnormality of chromosome stability (HP:0003220)2.50565577
74Absent hand (HP:0004050)2.49371317
75Neoplasm of the adrenal gland (HP:0100631)2.48832372
76Volvulus (HP:0002580)2.46518257
77Aplasia/Hypoplasia of the uvula (HP:0010293)2.44558266
78Medial flaring of the eyebrow (HP:0010747)2.43922743
79Split foot (HP:0001839)2.40517610
80Ependymoma (HP:0002888)2.39345337
81Patent foramen ovale (HP:0001655)2.39136288
82Dysautonomia (HP:0002459)2.38890091
83Abnormality of the labia minora (HP:0012880)2.36733111
84Flat capital femoral epiphysis (HP:0003370)2.36252977
85Nephronophthisis (HP:0000090)2.35891341
86Short clavicles (HP:0000894)2.33749413
87Aqueductal stenosis (HP:0002410)2.33077483
88Abnormal lung lobation (HP:0002101)2.29796401
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.29000107
90Absent epiphyses (HP:0010577)2.29000107
91Microretrognathia (HP:0000308)2.28634707
92Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28072040
93Hyperinsulinemic hypoglycemia (HP:0000825)2.27196234
94Chromsome breakage (HP:0040012)2.26751081
95Meckel diverticulum (HP:0002245)2.26252949
96Hyperglycemia (HP:0003074)2.25879902
97Glioma (HP:0009733)2.25820435
98Oligodactyly (hands) (HP:0001180)2.25753974
99Pancreatic fibrosis (HP:0100732)2.25151752
100Abnormality of the ileum (HP:0001549)2.24076663
101Brittle hair (HP:0002299)2.23022300
102Hypoglycemic seizures (HP:0002173)2.17009425
103Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16578609
104Astrocytoma (HP:0009592)2.16097856
105Abnormality of the astrocytes (HP:0100707)2.16097856
106Abnormality of the proximal phalanges of the hand (HP:0009834)2.15770225
107Abnormality of endocrine pancreas physiology (HP:0012093)2.14560759
108Abnormality of the pancreatic islet cells (HP:0006476)2.14560759
109Genital tract atresia (HP:0001827)2.14060424
110Progressive inability to walk (HP:0002505)2.13852139
111Aplasia of the musculature (HP:0100854)2.11138947
112Methylmalonic aciduria (HP:0012120)2.10887686
113Pelvic girdle muscle weakness (HP:0003749)2.10822306
114Hypoglycemic coma (HP:0001325)2.10431536
115Adrenal hypoplasia (HP:0000835)2.09912615
116Shoulder girdle muscle weakness (HP:0003547)2.09429617
117Abnormal pancreas size (HP:0012094)2.09281906
118CNS demyelination (HP:0007305)2.09218738
119Postnatal microcephaly (HP:0005484)2.08926519
120Insulin-resistant diabetes mellitus (HP:0000831)2.08114927
121Vaginal atresia (HP:0000148)2.07025623
122Labial hypoplasia (HP:0000066)2.06536529
123Spastic paraparesis (HP:0002313)2.06433165
124Alopecia of scalp (HP:0002293)2.05734010
125Abnormality of vitamin B metabolism (HP:0004340)2.03303299
126Abnormality of the renal cortex (HP:0011035)2.03072628
127Progressive macrocephaly (HP:0004481)2.02387854
128Ectopic kidney (HP:0000086)2.01895560
129Abnormality of the parathyroid morphology (HP:0011766)2.01882997
130Aplasia/Hypoplasia of the clavicles (HP:0006710)2.01486690
131Abnormality of methionine metabolism (HP:0010901)2.01315779
132Acute encephalopathy (HP:0006846)2.00920561
133Aplasia/Hypoplasia of the fovea (HP:0008060)2.00292350
134Hypoplasia of the fovea (HP:0007750)2.00292350
135Congenital primary aphakia (HP:0007707)2.00096220
136Hyperuricemia (HP:0002149)2.00066655
137Increased purine levels (HP:0004368)2.00066655
138Rhabdomyosarcoma (HP:0002859)1.99940542
139Hypoplastic female external genitalia (HP:0012815)1.99800399
140Aplasia/hypoplasia of the humerus (HP:0006507)1.99732161
141Azoospermia (HP:0000027)1.99574743
142Abnormality of the renal medulla (HP:0100957)1.98451683
143Aplasia/Hypoplasia of the earlobes (HP:0009906)1.96547607
144Reduced subcutaneous adipose tissue (HP:0003758)1.96000768
145Heart block (HP:0012722)1.95222546
146Abnormality of the duodenum (HP:0002246)1.95220511
147Abolished electroretinogram (ERG) (HP:0000550)1.94317737
148Breast aplasia (HP:0100783)1.94025546
149Aplasia/Hypoplasia of the tongue (HP:0010295)1.93671933
150Oligodactyly (HP:0012165)1.93403863
151Bifid tongue (HP:0010297)1.93292260
152Dandy-Walker malformation (HP:0001305)1.92431008
153Large for gestational age (HP:0001520)1.92310750
154Abnormality of glycosphingolipid metabolism (HP:0004343)1.92040214
155Abnormality of glycolipid metabolism (HP:0010969)1.92040214
156Abnormality of liposaccharide metabolism (HP:0010968)1.92040214
157Gait imbalance (HP:0002141)1.91997827
158Breast carcinoma (HP:0003002)1.91963548
159Sloping forehead (HP:0000340)1.91698415
160Abnormality of the fovea (HP:0000493)1.91543299
161Abnormality of the preputium (HP:0100587)1.91204591
162Acute necrotizing encephalopathy (HP:0006965)1.90817644
163Restlessness (HP:0000711)1.90091200
164Disproportionate short-trunk short stature (HP:0003521)1.89430340
165Gastrointestinal atresia (HP:0002589)1.86292639
166Small intestinal stenosis (HP:0012848)1.85451940
167Duodenal stenosis (HP:0100867)1.85451940
168Preaxial hand polydactyly (HP:0001177)1.84404059
169Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.84382491
170Nephrogenic diabetes insipidus (HP:0009806)1.83872799
171Abnormality of the vitamin B12 metabolism (HP:0004341)1.83620349
172Increased CSF lactate (HP:0002490)1.79855117
173Furrowed tongue (HP:0000221)1.77852696
174Abnormality of the metopic suture (HP:0005556)1.75940967
175Hypoplastic labia majora (HP:0000059)1.75464395
176Prominent metopic ridge (HP:0005487)1.74836515
177Embryonal renal neoplasm (HP:0011794)1.73067703
178Pendular nystagmus (HP:0012043)1.73045459
179Renal hypoplasia (HP:0000089)1.72784596
180Sclerocornea (HP:0000647)1.72638878
181Chronic hepatic failure (HP:0100626)1.72634043
182Septo-optic dysplasia (HP:0100842)1.72561731
183Anencephaly (HP:0002323)1.69352100
184Nephroblastoma (Wilms tumor) (HP:0002667)1.68742935
185Stenosis of the external auditory canal (HP:0000402)1.68600340
186Horseshoe kidney (HP:0000085)1.67943139
187Small hand (HP:0200055)1.67320402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB16.83195747
2WEE14.75179435
3AKT34.16917190
4FRK4.00819165
5EPHA23.61281314
6PLK43.44511238
7TSSK63.38270926
8TRIM283.38020877
9EIF2AK13.13974542
10TNIK3.07251959
11STK163.00985161
12BMPR1B2.62623613
13MST42.56606267
14BRSK22.52040313
15SRPK12.26216075
16NEK22.23412591
17PNCK2.18058358
18ZAK2.11707356
19EIF2AK32.10055235
20TTK2.03721933
21PLK31.91572396
22IRAK31.88245241
23PLK21.79067879
24ERBB31.78068176
25BRSK11.76231716
26PLK11.73680002
27ACVR1B1.73565393
28STK391.70114084
29NEK11.67703197
30PINK11.62930855
31PDK31.62907542
32PDK41.62907542
33CASK1.55930139
34FGFR21.51880837
35ARAF1.51417624
36DYRK31.49253819
37MAP4K21.47189627
38TAF11.44362342
39PDK21.44072110
40MKNK21.43399559
41PBK1.37066457
42NME21.33804761
43TESK21.33431899
44OXSR11.29221712
45BRAF1.25060405
46CCNB11.24741989
47ADRBK21.22273927
48MKNK11.19248592
49STK38L1.16981226
50MAP3K41.16886145
51CHEK21.12982349
52INSRR1.10091871
53PAK31.07439083
54STK31.07227727
55ERBB41.04894202
56AURKA1.02824968
57WNK41.02701005
58AURKB1.02180727
59FER1.01951525
60TGFBR10.96041264
61PIM20.93699844
62MAPK130.89495488
63NME10.88126754
64LATS20.86600385
65NLK0.85452834
66SIK30.84683853
67MAP3K120.82099118
68PRKCE0.80525382
69PRKCI0.76136739
70MAP3K80.73993287
71CSNK1G30.73979742
72CDC70.71803415
73EIF2AK20.70764702
74RPS6KA40.70452033
75VRK10.69344663
76VRK20.69134012
77PAK10.67719201
78CHEK10.64851201
79FGFR10.63905256
80STK240.63338858
81CSNK1A1L0.57433621
82CSNK1G10.57383947
83ALK0.56318799
84CDK70.54608937
85CAMKK20.53859475
86DYRK20.52161580
87ATR0.49522106
88ADRBK10.49435683
89CDK40.49242570
90CDK20.47747482
91FLT30.47104710
92YES10.46152974
93CSNK2A10.46123679
94LATS10.45732511
95ABL20.45696429
96CDK30.43453110
97CSNK1G20.43440318
98CSNK1E0.43376355
99MINK10.43367948
100BCKDK0.42108810
101MAP2K20.41423993
102TIE10.41205974
103MARK10.41143670
104TGFBR20.40723382
105NUAK10.40192159
106MAP2K70.40067540
107CSNK2A20.39376762
108WNK30.39355572
109STK100.38916429
110RAF10.37614951
111MAP3K30.37321578
112CDK10.36658570
113BCR0.36093784
114PRKCG0.35501336
115PASK0.35428147
116PHKG20.35017084
117PHKG10.35017084
118MELK0.33638789
119CSNK1A10.33508814
120PRKAA10.33463686
121TLK10.31673664
122EPHA40.30801309
123MUSK0.30244965
124RPS6KA50.29863979
125BRD40.29544309
126IRAK20.28514482
127PIM10.27660587
128PTK2B0.26761059
129PRKDC0.26287258
130CSNK1D0.23790262
131NTRK30.23293010
132STK40.23176756
133GRK70.22828079
134DAPK20.22581661
135ATM0.22362046
136NEK60.21551317
137RPS6KB20.21344960
138CAMK2G0.21085610
139MAP3K90.18968970
140MAPK100.13466028
141MTOR0.12814535
142AKT20.12769269
143MARK30.12218098
144MAP3K50.11819740
145TAOK20.11413417
146STK380.11050879
147KDR0.10754748
148PAK40.09705928
149CAMK2B0.09544509
150GRK10.08242298

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.57628408
2RNA polymerase_Homo sapiens_hsa030204.53137764
3Proteasome_Homo sapiens_hsa030504.51415303
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.17369142
5Folate biosynthesis_Homo sapiens_hsa007903.12485750
6Regulation of autophagy_Homo sapiens_hsa041403.03776846
7RNA transport_Homo sapiens_hsa030133.01333019
8Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.92710000
9Propanoate metabolism_Homo sapiens_hsa006402.62168671
10Pyrimidine metabolism_Homo sapiens_hsa002402.44763693
11Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.31718098
12Spliceosome_Homo sapiens_hsa030402.18202578
13Cell cycle_Homo sapiens_hsa041102.18085282
14DNA replication_Homo sapiens_hsa030302.17050692
15Basal transcription factors_Homo sapiens_hsa030222.05491874
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.98125423
17Glycerophospholipid metabolism_Homo sapiens_hsa005641.97917098
18Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.92082628
19Pentose phosphate pathway_Homo sapiens_hsa000301.87624916
20Vitamin digestion and absorption_Homo sapiens_hsa049771.86890358
21Homologous recombination_Homo sapiens_hsa034401.76728195
22Mismatch repair_Homo sapiens_hsa034301.76717197
23Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.74409745
24Purine metabolism_Homo sapiens_hsa002301.68968706
25Nucleotide excision repair_Homo sapiens_hsa034201.67282910
26Base excision repair_Homo sapiens_hsa034101.61687861
27p53 signaling pathway_Homo sapiens_hsa041151.53380373
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47578839
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41832704
30Caffeine metabolism_Homo sapiens_hsa002321.40369412
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.39503996
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.38115033
33Ribosome_Homo sapiens_hsa030101.35755639
34Phototransduction_Homo sapiens_hsa047441.32494994
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29036404
36Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.28815086
37Oxidative phosphorylation_Homo sapiens_hsa001901.28693980
38Pyruvate metabolism_Homo sapiens_hsa006201.24893195
39Fanconi anemia pathway_Homo sapiens_hsa034601.23256047
40Oocyte meiosis_Homo sapiens_hsa041141.23094282
41Epstein-Barr virus infection_Homo sapiens_hsa051691.22166087
42Fructose and mannose metabolism_Homo sapiens_hsa000511.21985732
43Nitrogen metabolism_Homo sapiens_hsa009101.16404370
44Peroxisome_Homo sapiens_hsa041461.16365854
45Tryptophan metabolism_Homo sapiens_hsa003801.13731282
46Sulfur metabolism_Homo sapiens_hsa009201.10721294
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.08368620
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.05527193
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.04110236
50Primary bile acid biosynthesis_Homo sapiens_hsa001201.03663991
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.01726863
52Parkinsons disease_Homo sapiens_hsa050120.94661573
53Biosynthesis of amino acids_Homo sapiens_hsa012300.93881679
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.89985060
55RNA degradation_Homo sapiens_hsa030180.89964254
56Fatty acid degradation_Homo sapiens_hsa000710.89870324
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86696175
58Chemical carcinogenesis_Homo sapiens_hsa052040.86177603
59Circadian rhythm_Homo sapiens_hsa047100.83494702
60One carbon pool by folate_Homo sapiens_hsa006700.82129265
61Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82074555
62Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81953282
63mRNA surveillance pathway_Homo sapiens_hsa030150.73597810
64Sphingolipid metabolism_Homo sapiens_hsa006000.72708216
65Sulfur relay system_Homo sapiens_hsa041220.72473418
66Lysosome_Homo sapiens_hsa041420.70693689
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70196699
68Selenocompound metabolism_Homo sapiens_hsa004500.67250937
69Steroid hormone biosynthesis_Homo sapiens_hsa001400.66970598
702-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.66769651
71Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66165716
72Carbon metabolism_Homo sapiens_hsa012000.64922267
73Metabolic pathways_Homo sapiens_hsa011000.63825147
74Glutathione metabolism_Homo sapiens_hsa004800.63508792
75Steroid biosynthesis_Homo sapiens_hsa001000.62218911
76TGF-beta signaling pathway_Homo sapiens_hsa043500.60748582
77Renin-angiotensin system_Homo sapiens_hsa046140.57731149
78Nicotine addiction_Homo sapiens_hsa050330.57482119
79Protein export_Homo sapiens_hsa030600.55318665
80Glycerolipid metabolism_Homo sapiens_hsa005610.54349066
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53370439
82Arginine and proline metabolism_Homo sapiens_hsa003300.50922261
83Basal cell carcinoma_Homo sapiens_hsa052170.47724696
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47636568
85Taste transduction_Homo sapiens_hsa047420.46437922
86Alzheimers disease_Homo sapiens_hsa050100.45685177
87N-Glycan biosynthesis_Homo sapiens_hsa005100.45404875
88Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.45119620
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44585557
90Mineral absorption_Homo sapiens_hsa049780.42503501
91Antigen processing and presentation_Homo sapiens_hsa046120.42308440
92Non-homologous end-joining_Homo sapiens_hsa034500.40497445
93Linoleic acid metabolism_Homo sapiens_hsa005910.40284646
94Butanoate metabolism_Homo sapiens_hsa006500.40282090
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.39704337
96Insulin secretion_Homo sapiens_hsa049110.37723063
97Arachidonic acid metabolism_Homo sapiens_hsa005900.37645772
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36339306
99Galactose metabolism_Homo sapiens_hsa000520.32570326
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30565519
101Collecting duct acid secretion_Homo sapiens_hsa049660.30303444
102alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24747758
103Huntingtons disease_Homo sapiens_hsa050160.24648668
104mTOR signaling pathway_Homo sapiens_hsa041500.24000762
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.23999485
106FoxO signaling pathway_Homo sapiens_hsa040680.22639420
107Ether lipid metabolism_Homo sapiens_hsa005650.21896125
108beta-Alanine metabolism_Homo sapiens_hsa004100.21536544
109Viral carcinogenesis_Homo sapiens_hsa052030.21350266
110Retinol metabolism_Homo sapiens_hsa008300.19808691
111Cyanoamino acid metabolism_Homo sapiens_hsa004600.19643613
112Fatty acid elongation_Homo sapiens_hsa000620.19266377
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.16157702
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.15345746
115Inositol phosphate metabolism_Homo sapiens_hsa005620.15221388
116Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.13824030
117Hippo signaling pathway_Homo sapiens_hsa043900.13426009
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.12090728
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.11213325
120Tight junction_Homo sapiens_hsa045300.09706371
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.07190284
122Hedgehog signaling pathway_Homo sapiens_hsa043400.06775196
123Fat digestion and absorption_Homo sapiens_hsa049750.06223823
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.03927359
125Renal cell carcinoma_Homo sapiens_hsa052110.02538704
126Herpes simplex infection_Homo sapiens_hsa051680.01942437
127Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.01797436
128Endocytosis_Homo sapiens_hsa041440.00914957
129Legionellosis_Homo sapiens_hsa05134-0.0160156
130Fatty acid metabolism_Homo sapiens_hsa01212-0.0138414
131HTLV-I infection_Homo sapiens_hsa05166-0.0087466
132Pathogenic Escherichia coli infection_Homo sapiens_hsa05130-0.0069463
133Prion diseases_Homo sapiens_hsa05020-0.0015616
134Pentose and glucuronate interconversions_Homo sapiens_hsa00040-0.0003094

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