TMEM31

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chromosome condensation (GO:0030261)9.76362692
2DNA packaging (GO:0006323)9.27928571
3sperm capacitation (GO:0048240)9.12896236
4plasma membrane fusion (GO:0045026)8.86229713
5microtubule depolymerization (GO:0007019)8.66077858
6single strand break repair (GO:0000012)8.41757828
7spermatid nucleus differentiation (GO:0007289)8.41066332
8spermatid development (GO:0007286)7.84381418
9sperm-egg recognition (GO:0035036)7.65495089
10binding of sperm to zona pellucida (GO:0007339)7.19978424
11microtubule polymerization or depolymerization (GO:0031109)7.05815049
12rRNA methylation (GO:0031167)7.00614195
13multicellular organism reproduction (GO:0032504)6.90800201
14negative regulation of inclusion body assembly (GO:0090084)6.76301681
15sexual reproduction (GO:0019953)6.74390811
16calcium ion-dependent exocytosis (GO:0017156)6.71160927
17reproduction (GO:0000003)6.62180159
18protein polyglutamylation (GO:0018095)6.60762202
19protein targeting to Golgi (GO:0000042)6.34801298
20cell-cell recognition (GO:0009988)6.26857366
21spermatogenesis (GO:0007283)6.13059621
22male gamete generation (GO:0048232)6.10905875
23axonemal dynein complex assembly (GO:0070286)6.09435416
24establishment of protein localization to Golgi (GO:0072600)6.08893743
25rRNA modification (GO:0000154)5.95993787
26retrograde transport, vesicle recycling within Golgi (GO:0000301)5.91711173
27phosphatidylethanolamine biosynthetic process (GO:0006646)5.84427632
28cellular ketone body metabolic process (GO:0046950)5.68778999
29gamete generation (GO:0007276)5.58555334
30antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.53375325
31centriole replication (GO:0007099)5.52780199
32microtubule severing (GO:0051013)5.42378255
33phosphatidylethanolamine metabolic process (GO:0046337)5.40787427
34regulation of Rab GTPase activity (GO:0032313)5.23839668
35positive regulation of Rab GTPase activity (GO:0032851)5.23839668
36regulation of cilium movement (GO:0003352)5.01428079
37ketone body metabolic process (GO:1902224)5.01241966
38regulation of inclusion body assembly (GO:0090083)4.92520007
39motile cilium assembly (GO:0044458)4.86237904
40single fertilization (GO:0007338)4.83011542
41centriole assembly (GO:0098534)4.80931403
42chromatin silencing (GO:0006342)4.74550185
43regulation of transcription involved in cell fate commitment (GO:0060850)4.65119405
44protein localization to Golgi apparatus (GO:0034067)4.60244860
45regulation of centriole replication (GO:0046599)4.49133462
46multicellular organismal reproductive process (GO:0048609)4.45885804
47cell wall macromolecule catabolic process (GO:0016998)4.43678923
48germ cell development (GO:0007281)4.42861736
49RNA destabilization (GO:0050779)4.39697193
50coenzyme catabolic process (GO:0009109)4.38343138
51cilium or flagellum-dependent cell motility (GO:0001539)4.29906641
52seminiferous tubule development (GO:0072520)4.28090711
53cellular process involved in reproduction in multicellular organism (GO:0022412)4.27369553
54cell wall macromolecule metabolic process (GO:0044036)4.20947054
55glycerol ether metabolic process (GO:0006662)4.16741725
56nucleus organization (GO:0006997)4.07321116
57negative regulation of Rho protein signal transduction (GO:0035024)4.04432977
58fertilization (GO:0009566)3.95076093
59ether metabolic process (GO:0018904)3.85077216
60epithelial cilium movement (GO:0003351)3.83860518
61musculoskeletal movement (GO:0050881)3.62793275
62multicellular organismal movement (GO:0050879)3.62793275
63cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.43840381
64polyamine biosynthetic process (GO:0006596)3.42506615
65regulation of microtubule-based movement (GO:0060632)3.39915756
66cilium movement (GO:0003341)3.39773140
67cerebral cortex neuron differentiation (GO:0021895)3.37758241
68organic cation transport (GO:0015695)3.33733980
69response to acidic pH (GO:0010447)3.28437055
70protein-DNA complex disassembly (GO:0032986)3.26579723
71nucleosome disassembly (GO:0006337)3.26579723
72negative regulation of gene expression, epigenetic (GO:0045814)3.26319255
73protein depolymerization (GO:0051261)3.24737557
74glomerular visceral epithelial cell development (GO:0072015)3.24477998
75cranial nerve morphogenesis (GO:0021602)3.23074746
76mesenchymal cell differentiation involved in kidney development (GO:0072161)3.21557343
77mesenchymal cell differentiation involved in renal system development (GO:2001012)3.21557343
78regulation of somitogenesis (GO:0014807)3.20021386
79cell differentiation involved in metanephros development (GO:0072202)3.18213647
80regulation of interleukin-13 production (GO:0032656)3.16791460
81histone H3-K9 demethylation (GO:0033169)3.16188978
82glomerular epithelial cell development (GO:0072310)3.14419074
83microtubule nucleation (GO:0007020)3.11878151
84cellular response to pH (GO:0071467)3.11493620
85peptidyl-threonine dephosphorylation (GO:0035970)3.09993342
86cell recognition (GO:0008037)3.04966461
87membrane protein intracellular domain proteolysis (GO:0031293)3.01896694
88DNA conformation change (GO:0071103)2.99076588
89regulation of T-helper 2 cell differentiation (GO:0045628)2.97047312
90NAD biosynthetic process (GO:0009435)2.94500559
91multicellular organismal development (GO:0007275)2.92122832
92negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.89303004
93homeostasis of number of cells within a tissue (GO:0048873)2.80873246
94positive regulation of skeletal muscle tissue development (GO:0048643)2.74342557
95tooth mineralization (GO:0034505)2.74276092
96positive regulation of endothelial cell differentiation (GO:0045603)2.74251938
97acrosome reaction (GO:0007340)12.2275580
98fusion of sperm to egg plasma membrane (GO:0007342)11.6806789
99sperm motility (GO:0030317)11.3588201
100response to pheromone (GO:0019236)10.1090921

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.96351604
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.06921723
3MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human3.82566389
4TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45440725
5POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.45440725
6CTBP2_25329375_ChIP-Seq_LNCAP_Human2.25866070
7IRF4_20064451_ChIP-Seq_CD4+T_Mouse2.21141860
8CBP_20019798_ChIP-Seq_JUKART_Human2.21141860
9ELF1_20517297_ChIP-Seq_JURKAT_Human2.11927293
10EZH2_22144423_ChIP-Seq_EOC_Human2.09149017
11ERA_21632823_ChIP-Seq_H3396_Human2.06426607
12CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04242000
13VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.97413420
14FUS_26573619_Chip-Seq_HEK293_Human1.93638219
15RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.91440906
16RAC3_21632823_ChIP-Seq_H3396_Human1.90144948
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.87013304
18NANOG_20526341_ChIP-Seq_ESCs_Human1.86015794
19EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.85078318
20* EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.79977193
21UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.79955516
22CTCF_27219007_Chip-Seq_Bcells_Human1.77521347
23WDR5_24793694_ChIP-Seq_LNCAP_Human1.76595705
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.75864638
25DROSHA_22980978_ChIP-Seq_HELA_Human1.74599385
26BCL6_27268052_Chip-Seq_Bcells_Human1.68160598
27MYC_19829295_ChIP-Seq_ESCs_Human1.67196720
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.67144569
29YY1_22570637_ChIP-Seq_MALME-3M_Human1.65007083
30E2F1_20622854_ChIP-Seq_HELA_Human1.63512356
31TAF2_19829295_ChIP-Seq_ESCs_Human1.61765152
32TDRD3_21172665_ChIP-Seq_MCF-7_Human1.61451857
33AUTS2_25519132_ChIP-Seq_293T-REX_Human1.56280154
34SMAD4_21741376_ChIP-Seq_EPCs_Human1.54070444
35SMC4_20622854_ChIP-Seq_HELA_Human1.54057045
36ER_23166858_ChIP-Seq_MCF-7_Human1.53744280
37PHF8_20622854_ChIP-Seq_HELA_Human1.52927713
38PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.52079291
39CTCF_20526341_ChIP-Seq_ESCs_Human1.51631422
40ETV2_25802403_ChIP-Seq_MESCs_Mouse1.50761457
41ARNT_22903824_ChIP-Seq_MCF-7_Human1.49546420
42P68_20966046_ChIP-Seq_HELA_Human1.49402812
43BCOR_27268052_Chip-Seq_Bcells_Human1.48934129
44SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47978530
45NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45802933
46TP63_22573176_ChIP-Seq_HFKS_Human1.44791364
47OCT4_20526341_ChIP-Seq_ESCs_Human1.44212492
48TP53_18474530_ChIP-ChIP_U2OS_Human1.43789442
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.40547219
50AR_25329375_ChIP-Seq_VCAP_Human1.39509844
51TAF15_26573619_Chip-Seq_HEK293_Human1.39226115
52SUZ12_27294783_Chip-Seq_ESCs_Mouse1.36233163
53CBX2_22325352_ChIP-Seq_293T-Rex_Human1.34219203
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.34002401
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.32704536
56RBPJ_21746931_ChIP-Seq_IB4_Human1.32672526
57LXR_22292898_ChIP-Seq_THP-1_Human1.31114190
58SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.30840018
59P300_27268052_Chip-Seq_Bcells_Human1.30530204
60SMAD3_21741376_ChIP-Seq_ESCs_Human1.29985489
61TP63_19390658_ChIP-ChIP_HaCaT_Human1.29838833
62P300_19829295_ChIP-Seq_ESCs_Human1.28910762
63SOX2_22085726_ChIP-Seq_NPCs_Mouse1.28798800
64KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.27746392
65ETV1_20927104_ChIP-Seq_GIST48_Human1.27383805
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24683686
67ERG_20517297_ChIP-Seq_VCAP_Human1.24536209
68ZNF274_21170338_ChIP-Seq_K562_Hela1.23195316
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22616706
70P63_20808887_ChIP-Seq_KERATINOCYTES_Human1.22607824
71NFYB_21822215_ChIP-Seq_K562_Human1.22452363
72* GATA3_21878914_ChIP-Seq_MCF-7_Human1.21629244
73P53_21459846_ChIP-Seq_SAOS-2_Human1.21552795
74KLF5_20875108_ChIP-Seq_MESCs_Mouse1.21108826
75CEBPB_22108803_ChIP-Seq_LS180_Human1.20266113
76TBL1_22424771_ChIP-Seq_293T_Human1.18752832
77PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18060477
78EZH2_27294783_Chip-Seq_ESCs_Mouse1.15830977
79SA1_27219007_Chip-Seq_Bcells_Human1.13066208
80PHF8_20622853_ChIP-Seq_HELA_Human1.12919864
81RUNX1_26923725_Chip-Seq_HPCs_Mouse1.11891154
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.11545491
83EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.10956841
84* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10589136
85RUNX2_22187159_ChIP-Seq_PCA_Human1.09632964
86GATA6_21074721_ChIP-Seq_CACO-2_Human1.09197740
87* SMAD4_21741376_ChIP-Seq_HESCs_Human1.08907200
88SMRT_27268052_Chip-Seq_Bcells_Human1.07136105
89HOXB7_26014856_ChIP-Seq_BT474_Human1.07119855
90ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06836816
91RUNX_20019798_ChIP-Seq_JUKART_Human1.06409618
92SOX2_19829295_ChIP-Seq_ESCs_Human1.05799695
93NANOG_19829295_ChIP-Seq_ESCs_Human1.05799695
94NFYA_21822215_ChIP-Seq_K562_Human1.01657542
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.00185155
96GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.99257606
97PCGF4_22325352_ChIP-Seq_293T-Rex_Human0.97522594
98VDR_22108803_ChIP-Seq_LS180_Human0.95803302
99GF1_26923725_Chip-Seq_HPCs_Mouse0.94986614
100OCT1_27270436_Chip-Seq_PROSTATE_Human0.94581177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005377_hearing/vestibular/ear_phenot5.01250124
2MP0003878_abnormal_ear_physiology5.01250124
3MP0003698_abnormal_male_reproductive4.34900808
4MP0005670_abnormal_white_adipose4.27310753
5MP0001929_abnormal_gametogenesis3.73432476
6MP0001348_abnormal_lacrimal_gland3.54330896
7MP0000678_abnormal_parathyroid_gland2.69279899
8MP0003011_delayed_dark_adaptation2.61981699
9MP0002161_abnormal_fertility/fecundity2.44147198
10MP0003718_maternal_effect2.30497529
11MP0002132_abnormal_respiratory_system2.20653449
12MP0005410_abnormal_fertilization12.0917926
13MP0002234_abnormal_pharynx_morphology1.97621832
14MP0005423_abnormal_somatic_nervous1.89967271
15MP0005379_endocrine/exocrine_gland_phen1.83761607
16MP0003646_muscle_fatigue1.78660680
17MP0002249_abnormal_larynx_morphology1.71090419
18MP0004510_myositis1.65873747
19MP0002210_abnormal_sex_determination1.61987146
20MP0009053_abnormal_anal_canal1.57073509
21MP0001486_abnormal_startle_reflex1.53225071
22MP0001485_abnormal_pinna_reflex1.52420681
23MP0002282_abnormal_trachea_morphology1.51901757
24MP0002822_catalepsy1.40260362
25MP0001145_abnormal_male_reproductive1.35773966
26MP0000534_abnormal_ureter_morphology1.31271763
27MP0004742_abnormal_vestibular_system1.30829146
28MP0000653_abnormal_sex_gland1.29184567
29MP0005310_abnormal_salivary_gland1.28919420
30MP0001968_abnormal_touch/_nociception1.26768793
31MP0004859_abnormal_synaptic_plasticity1.24187197
32MP0002735_abnormal_chemical_nociception1.21723710
33MP0002127_abnormal_cardiovascular_syste1.21096104
34MP0005248_abnormal_Harderian_gland1.15372941
35MP0001765_abnormal_ion_homeostasis1.13755997
36MP0001963_abnormal_hearing_physiology1.11639168
37MP0000026_abnormal_inner_ear1.07146208
38MP0000049_abnormal_middle_ear0.99701793
39MP0005395_other_phenotype0.99162336
40MP0002138_abnormal_hepatobiliary_system0.96188755
41MP0006292_abnormal_olfactory_placode0.95933454
42MP0000955_abnormal_spinal_cord0.93061408
43MP0003879_abnormal_hair_cell0.92467812
44MP0000681_abnormal_thyroid_gland0.88545584
45MP0002733_abnormal_thermal_nociception0.86785600
46MP0002229_neurodegeneration0.86272366
47MP0008877_abnormal_DNA_methylation0.81994291
48MP0000516_abnormal_urinary_system0.80734871
49MP0005367_renal/urinary_system_phenotyp0.80734871
50MP0005551_abnormal_eye_electrophysiolog0.80280237
51MP0004085_abnormal_heartbeat0.79398355
52MP0001879_abnormal_lymphatic_vessel0.79156612
53MP0002653_abnormal_ependyma_morphology0.78902338
54MP0002067_abnormal_sensory_capabilities0.75149204
55MP0008569_lethality_at_weaning0.74270986
56MP0002557_abnormal_social/conspecific_i0.73825963
57MP0005451_abnormal_body_composition0.73711125
58MP0005253_abnormal_eye_physiology0.72589210
59MP0005083_abnormal_biliary_tract0.71600247
60MP0008995_early_reproductive_senescence0.68468307
61MP0009697_abnormal_copulation0.66716218
62MP0005636_abnormal_mineral_homeostasis0.64727932
63MP0003119_abnormal_digestive_system0.62508992
64MP0003880_abnormal_central_pattern0.62477482
65MP0005623_abnormal_meninges_morphology0.61948067
66MP0002572_abnormal_emotion/affect_behav0.61519420
67MP0001905_abnormal_dopamine_level0.61310785
68MP0005167_abnormal_blood-brain_barrier0.61272076
69MP0004484_altered_response_of0.61074103
70MP0008789_abnormal_olfactory_epithelium0.60177030
71MP0009115_abnormal_fat_cell0.58662465
72MP0005666_abnormal_adipose_tissue0.57522561
73MP0001970_abnormal_pain_threshold0.56875138
74MP0002272_abnormal_nervous_system0.55011017
75MP0002734_abnormal_mechanical_nocicepti0.54911265
76MP0001984_abnormal_olfaction0.54815343
77MP0005499_abnormal_olfactory_system0.52967144
78MP0005394_taste/olfaction_phenotype0.52967144
79MP0001666_abnormal_nutrient_absorption0.52701843
80MP0003077_abnormal_cell_cycle0.52171267
81MP0003137_abnormal_impulse_conducting0.51407188
82MP0005375_adipose_tissue_phenotype0.51287111
83MP0009745_abnormal_behavioral_response0.48548985
84MP0004233_abnormal_muscle_weight0.48199572
85MP0000566_synostosis0.46933591
86MP0002928_abnormal_bile_duct0.46126156
87MP0003942_abnormal_urinary_system0.45261883
88MP0000003_abnormal_adipose_tissue0.44358851
89MP0001440_abnormal_grooming_behavior0.42822809
90MP0003635_abnormal_synaptic_transmissio0.41225151
91MP0005391_vision/eye_phenotype0.40678266
92MP0005535_abnormal_body_temperature0.40677125
93MP0003699_abnormal_female_reproductive0.39806577
94MP0002882_abnormal_neuron_morphology0.39258727
95MP0003936_abnormal_reproductive_system0.39204589
96MP0005084_abnormal_gallbladder_morpholo0.38599179
97MP0001501_abnormal_sleep_pattern0.37152965
98MP0008961_abnormal_basal_metabolism0.36906428
99MP0005408_hypopigmentation0.36139835
100MP0000249_abnormal_blood_vessel0.35493031

Predicted human phenotypes

RankGene SetZ-score
1Severe visual impairment (HP:0001141)8.64368283
2Dynein arm defect of respiratory motile cilia (HP:0012255)5.91110517
3Absent/shortened dynein arms (HP:0200106)5.91110517
4Asymmetric septal hypertrophy (HP:0001670)5.26254433
5Attenuation of retinal blood vessels (HP:0007843)5.17426381
6Bony spicule pigmentary retinopathy (HP:0007737)5.14615068
7Abnormal ciliary motility (HP:0012262)4.57854463
8Resting tremor (HP:0002322)4.53857205
9Bell-shaped thorax (HP:0001591)4.53011956
10Abnormal respiratory motile cilium physiology (HP:0012261)4.45247553
11Abnormal respiratory motile cilium morphology (HP:0005938)4.36000137
12Abnormal respiratory epithelium morphology (HP:0012253)4.36000137
13Abnormal rod and cone electroretinograms (HP:0008323)4.29636439
14Hypoplastic ischia (HP:0003175)4.26796387
15Tubulointerstitial nephritis (HP:0001970)4.25234868
16Parkinsonism with favorable response to dopaminergic medication (HP:0002548)4.19683601
17Infertility (HP:0000789)4.15031122
18Male infertility (HP:0003251)4.09200191
19Enlarged epiphyses (HP:0010580)3.99148191
20Abnormality of macular pigmentation (HP:0008002)3.99118132
21Nasal polyposis (HP:0100582)3.95800572
22Chronic hepatic failure (HP:0100626)3.88356296
23Potter facies (HP:0002009)3.81425082
24Facial shape deformation (HP:0011334)3.81425082
25Abnormality of the ischium (HP:0003174)3.79313155
26Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.78544500
27Hyperkalemia (HP:0002153)3.74585655
28Aplasia/Hypoplasia of the earlobes (HP:0009906)3.60453665
29Azoospermia (HP:0000027)3.60187042
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.53436783
31Abnormal spermatogenesis (HP:0008669)3.48555414
32Unilateral renal agenesis (HP:0000122)3.47208306
33Cone-rod dystrophy (HP:0000548)3.32169392
34Congenital malformation of the right heart (HP:0011723)3.30132969
35Double outlet right ventricle (HP:0001719)3.30132969
36Impulsivity (HP:0100710)3.18451257
37Abnormality of the nasal mucosa (HP:0000433)3.17313419
38Abnormality of the aortic arch (HP:0012303)3.10840864
39Hypoplasia of the thymus (HP:0000778)2.95277248
40Renal dysplasia (HP:0000110)2.90087966
41Postural instability (HP:0002172)2.81645304
42Generalized aminoaciduria (HP:0002909)2.79660431
43Rhinitis (HP:0012384)2.73708771
44Abnormal urine output (HP:0012590)2.71641587
45Nephronophthisis (HP:0000090)2.68555960
46Progressive sensorineural hearing impairment (HP:0000408)2.64430559
47Stage 5 chronic kidney disease (HP:0003774)2.62472247
48Abnormality of the parathyroid morphology (HP:0011766)2.52155960
49Progressive cerebellar ataxia (HP:0002073)2.48870941
50Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.48384371
51Absent epiphyses (HP:0010577)2.48384371
52Epiphyseal dysplasia (HP:0002656)2.45930387
53Hypoalphalipoproteinemia (HP:0003233)2.41163466
54Abnormality of the costochondral junction (HP:0000919)2.35987603
55Amelogenesis imperfecta (HP:0000705)2.34258799
56Abnormality of renal excretion (HP:0011036)2.31869194
57Truncal obesity (HP:0001956)2.30648945
58Abnormality of potassium homeostasis (HP:0011042)2.30365962
59Abnormal drinking behavior (HP:0030082)2.28726296
60Polydipsia (HP:0001959)2.28726296
61Ventricular tachycardia (HP:0004756)2.28549669
62Abnormality of the renal medulla (HP:0100957)2.27580713
63Abnormality of dental color (HP:0011073)2.24416392
64Flattened epiphyses (HP:0003071)2.24411870
65Abnormality of the pubic bones (HP:0003172)2.22849627
66Polyuria (HP:0000103)2.17001396
67Portal hypertension (HP:0001409)2.16778595
68Abnormality of the epiphysis of the femoral head (HP:0010574)2.15913483
69Osteomalacia (HP:0002749)2.15085001
70Sensory axonal neuropathy (HP:0003390)2.08621061
71Aplasia/Hypoplasia of the sacrum (HP:0008517)2.06340360
72Insulin-resistant diabetes mellitus (HP:0000831)2.05527902
73Tetany (HP:0001281)2.04911938
74Spastic paraparesis (HP:0002313)2.04717633
75Tubulointerstitial abnormality (HP:0001969)2.03623906
76Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.01817686
77Abnormality of femoral epiphyses (HP:0006499)2.01817686
78Pendular nystagmus (HP:0012043)1.98537123
79Decreased central vision (HP:0007663)1.98472466
80Transposition of the great arteries (HP:0001669)1.97381128
81Abnormal connection of the cardiac segments (HP:0011545)1.97381128
82Abnormal ventriculo-arterial connection (HP:0011563)1.97381128
83Abnormality of the hepatic vasculature (HP:0006707)1.96634386
84Optic nerve hypoplasia (HP:0000609)1.95237646
85Bronchiectasis (HP:0002110)1.94303273
86Hyponatremia (HP:0002902)1.93559475
87Abnormality of the femoral head (HP:0003368)1.91991301
88Hypophosphatemic rickets (HP:0004912)1.91447833
89Recurrent corneal erosions (HP:0000495)1.91076904
90Renal Fanconi syndrome (HP:0001994)1.89715391
91Mixed hearing impairment (HP:0000410)1.89338048
92Myokymia (HP:0002411)1.88604482
93Widely patent fontanelles and sutures (HP:0004492)1.88050771
94Focal segmental glomerulosclerosis (HP:0000097)1.87666494
95Hyperthyroidism (HP:0000836)1.87609464
96Renovascular hypertension (HP:0100817)1.87537815
97Short ribs (HP:0000773)1.86386001
98Hypoplastic left heart (HP:0004383)1.85454385
99Flat capital femoral epiphysis (HP:0003370)1.85033708
100Intellectual disability, moderate (HP:0002342)1.83878096

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PLK48.60090178
2TESK16.40815811
3DDR25.47718067
4INSRR4.27183503
5MAP4K24.08677057
6PLK23.32053790
7BRD43.01356778
8STK382.62906992
9MAPK152.57221416
10PNCK2.45647803
11STK38L2.01958206
12PRKD31.99156089
13CAMK1G1.94689212
14WNK11.70956861
15PIK3CG1.67313990
16MST1R1.53203876
17PDPK11.39732656
18CDK71.36574817
19DYRK1B1.31741630
20PDK11.30924062
21PTK2B1.15338479
22CDK121.12193186
23MAP3K91.02614131
24NEK61.00228889
25KSR20.90750296
26UHMK10.88497234
27LATS20.80551119
28AKT30.76195653
29CAMK1D0.73520534
30MAP3K110.70681275
31RPS6KA20.67734501
32TYRO30.66947139
33BRAF0.66913427
34PRKG20.64729683
35PRKG10.64236346
36PRKAA20.62366392
37ROCK10.56918961
38RPS6KA10.56092228
39CDK30.52203169
40MAP3K80.51967142
41CAMK10.51350024
42MARK10.51250882
43WNK40.49408248
44MUSK0.49048563
45MAP3K20.47982973
46MAP2K20.47267002
47STK390.45224505
48TESK20.44217036
49GSK3B0.43440918
50PRKCG0.42777308
51MAP3K40.42612083
52CDK20.42458229
53CDK10.41504498
54CAMK40.41320352
55SIK20.40551761
56CDK40.39160395
57NTRK30.37305157
58MAPK10.36220326
59ARAF0.35290716
60BMPR1B0.34824153
61RPS6KC10.34369654
62RPS6KL10.34369654
63LATS10.34163699
64BRSK10.33602049
65MAPK80.32350386
66SGK2230.32110369
67SGK4940.32110369
68RPS6KA60.31808288
69PRKCZ0.30314738
70CHEK10.28735902
71TIE10.27249692
72MTOR0.27210321
73DYRK30.26819225
74PRKCB0.23477126
75MAPK140.21649187
76MAPK100.21430026
77MAPKAPK50.21409070
78TNIK0.20601850
79MINK10.18498252
80MARK20.18028877
81SGK10.16951678
82MET0.16375066
83AKT10.16207998
84PKN10.15658732
85MAP3K10.15150677
86OXSR10.15099869
87MAP2K70.14281990
88FER0.12661963
89PRKACA0.11452921
90CDK11A0.11303639
91FRK0.10941878
92CAMK2A0.10761970
93PINK10.10334571
94TRIM280.09283832
95BRSK20.07842307
96PRKACB0.07743615
97ROCK20.07197952
98MAPK90.07142518
99DYRK20.07107682
100BLK0.07107059

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000728.63174507
2Fatty acid biosynthesis_Homo sapiens_hsa000615.67403388
3Olfactory transduction_Homo sapiens_hsa047403.85289014
4Butanoate metabolism_Homo sapiens_hsa006502.84137378
5Taste transduction_Homo sapiens_hsa047421.91368490
6Glycerophospholipid metabolism_Homo sapiens_hsa005641.89615642
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.86514002
8Allograft rejection_Homo sapiens_hsa053301.85597069
9Type I diabetes mellitus_Homo sapiens_hsa049401.83137506
10Autoimmune thyroid disease_Homo sapiens_hsa053201.80515125
11Phenylalanine metabolism_Homo sapiens_hsa003601.77103344
12Graft-versus-host disease_Homo sapiens_hsa053321.67288914
13Antigen processing and presentation_Homo sapiens_hsa046121.63170339
14RNA transport_Homo sapiens_hsa030131.62960042
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.60061910
16Type II diabetes mellitus_Homo sapiens_hsa049301.56411463
17Fatty acid degradation_Homo sapiens_hsa000711.49703280
18Arginine and proline metabolism_Homo sapiens_hsa003301.44745054
19Dorso-ventral axis formation_Homo sapiens_hsa043201.43478524
20Fatty acid metabolism_Homo sapiens_hsa012121.36970334
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32150707
22Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.31882165
23Viral myocarditis_Homo sapiens_hsa054161.30334189
24Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22664059
25Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.20340222
26Endocytosis_Homo sapiens_hsa041441.17987949
27Cardiac muscle contraction_Homo sapiens_hsa042601.14776335
28Phototransduction_Homo sapiens_hsa047441.11470625
29Protein digestion and absorption_Homo sapiens_hsa049741.10489970
30Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04375272
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03668660
32Salivary secretion_Homo sapiens_hsa049700.98886487
33Morphine addiction_Homo sapiens_hsa050320.96401931
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95492589
35Arginine biosynthesis_Homo sapiens_hsa002200.94774084
36Synaptic vesicle cycle_Homo sapiens_hsa047210.94374028
37Oocyte meiosis_Homo sapiens_hsa041140.90870140
38Adipocytokine signaling pathway_Homo sapiens_hsa049200.85487085
39Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83488789
40Tyrosine metabolism_Homo sapiens_hsa003500.81982326
41cAMP signaling pathway_Homo sapiens_hsa040240.81975445
42Fat digestion and absorption_Homo sapiens_hsa049750.80574390
43Calcium signaling pathway_Homo sapiens_hsa040200.79106156
44Nicotine addiction_Homo sapiens_hsa050330.78775206
45Hedgehog signaling pathway_Homo sapiens_hsa043400.74999741
46Inositol phosphate metabolism_Homo sapiens_hsa005620.73410655
47Influenza A_Homo sapiens_hsa051640.71525232
48PPAR signaling pathway_Homo sapiens_hsa033200.68969788
49Circadian entrainment_Homo sapiens_hsa047130.68035923
50Renin-angiotensin system_Homo sapiens_hsa046140.66198400
51Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65682780
52Retinol metabolism_Homo sapiens_hsa008300.64263405
53Basal transcription factors_Homo sapiens_hsa030220.63927522
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.63799159
55Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62236813
56Estrogen signaling pathway_Homo sapiens_hsa049150.61121633
57Purine metabolism_Homo sapiens_hsa002300.59521616
58Glutamatergic synapse_Homo sapiens_hsa047240.58944528
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58006048
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.57823090
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57042434
62ABC transporters_Homo sapiens_hsa020100.55526078
63mRNA surveillance pathway_Homo sapiens_hsa030150.55239646
64Glycerolipid metabolism_Homo sapiens_hsa005610.54821998
65Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54537527
66Insulin secretion_Homo sapiens_hsa049110.54170135
67Bile secretion_Homo sapiens_hsa049760.48472525
68Gastric acid secretion_Homo sapiens_hsa049710.47814358
69Tight junction_Homo sapiens_hsa045300.47567578
70Serotonergic synapse_Homo sapiens_hsa047260.46049156
71Renin secretion_Homo sapiens_hsa049240.45773252
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45015629
73Selenocompound metabolism_Homo sapiens_hsa004500.43896739
74GABAergic synapse_Homo sapiens_hsa047270.42325933
75Cholinergic synapse_Homo sapiens_hsa047250.42123713
76Huntingtons disease_Homo sapiens_hsa050160.41550938
77MAPK signaling pathway_Homo sapiens_hsa040100.38900236
78Fanconi anemia pathway_Homo sapiens_hsa034600.36823440
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36706170
80Vascular smooth muscle contraction_Homo sapiens_hsa042700.36275259
81Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35287719
82VEGF signaling pathway_Homo sapiens_hsa043700.32843389
83Biosynthesis of amino acids_Homo sapiens_hsa012300.27902930
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.26370262
85Pancreatic secretion_Homo sapiens_hsa049720.25293618
86Oxytocin signaling pathway_Homo sapiens_hsa049210.23638577
87Viral carcinogenesis_Homo sapiens_hsa052030.23529459
88ECM-receptor interaction_Homo sapiens_hsa045120.22663089
89Nitrogen metabolism_Homo sapiens_hsa009100.20038785
90Metabolic pathways_Homo sapiens_hsa011000.19319832
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18672217
92Herpes simplex infection_Homo sapiens_hsa051680.17639527
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.17506325
94Epstein-Barr virus infection_Homo sapiens_hsa051690.16884782
95Legionellosis_Homo sapiens_hsa051340.14599639
96Adherens junction_Homo sapiens_hsa045200.14184164
97Acute myeloid leukemia_Homo sapiens_hsa052210.11366599
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.10849993
99Jak-STAT signaling pathway_Homo sapiens_hsa046300.09942276
100Propanoate metabolism_Homo sapiens_hsa006400.09522310

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