TMEM261

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.66114284
2viral transcription (GO:0019083)6.29119760
3DNA deamination (GO:0045006)6.24769787
4translational termination (GO:0006415)6.05643670
5ribosomal small subunit biogenesis (GO:0042274)5.84098688
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.54290915
7cotranslational protein targeting to membrane (GO:0006613)5.45097864
8protein targeting to ER (GO:0045047)5.40728286
9translational elongation (GO:0006414)5.40201671
10protein localization to endoplasmic reticulum (GO:0070972)5.16200064
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.10111179
12maturation of SSU-rRNA (GO:0030490)4.96740460
13viral life cycle (GO:0019058)4.81656985
14translational initiation (GO:0006413)4.71024251
15cellular protein complex disassembly (GO:0043624)4.70987216
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.63525966
17proteasome assembly (GO:0043248)4.62011671
18ribosomal large subunit biogenesis (GO:0042273)4.56513952
19deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.39366096
20cytochrome complex assembly (GO:0017004)4.37469726
21translation (GO:0006412)4.32011710
22mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.30585020
23protein neddylation (GO:0045116)4.24693058
24telomere maintenance via semi-conservative replication (GO:0032201)4.14248074
25protein complex disassembly (GO:0043241)4.06093728
26energy coupled proton transport, down electrochemical gradient (GO:0015985)4.05140790
27ATP synthesis coupled proton transport (GO:0015986)4.05140790
28ATP biosynthetic process (GO:0006754)4.04287491
29DNA strand elongation involved in DNA replication (GO:0006271)4.01889084
30negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.00973723
31ribonucleoprotein complex biogenesis (GO:0022613)3.89359959
32macromolecular complex disassembly (GO:0032984)3.86043172
33regulation of mitochondrial translation (GO:0070129)3.85207014
34hydrogen ion transmembrane transport (GO:1902600)3.84352109
35purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.84031362
36DNA strand elongation (GO:0022616)3.83390020
37purine nucleoside triphosphate biosynthetic process (GO:0009145)3.83259867
38formation of translation preinitiation complex (GO:0001731)3.73725342
39spliceosomal snRNP assembly (GO:0000387)3.72969668
40antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.67876932
41inner mitochondrial membrane organization (GO:0007007)3.67573092
42termination of RNA polymerase III transcription (GO:0006386)3.65136528
43transcription elongation from RNA polymerase III promoter (GO:0006385)3.65136528
44DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.64598984
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.64586726
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.63940173
47negative regulation of ligase activity (GO:0051352)3.63940173
48protein localization to mitochondrion (GO:0070585)3.62768943
49establishment of integrated proviral latency (GO:0075713)3.61572583
50regulation of cellular amino acid metabolic process (GO:0006521)3.61385908
51regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.60471518
52mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.57821370
53signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.56505519
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.56505519
55pseudouridine synthesis (GO:0001522)3.56218373
56rRNA processing (GO:0006364)3.55805246
57cellular component biogenesis (GO:0044085)3.55234607
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.54905196
59telomere maintenance via recombination (GO:0000722)3.54145118
60mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.53988829
61mitochondrial respiratory chain complex I assembly (GO:0032981)3.53988829
62NADH dehydrogenase complex assembly (GO:0010257)3.53988829
63signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.52652260
64signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.52652260
65signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.52652260
66anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.52127667
67protein targeting to membrane (GO:0006612)3.51904601
68rRNA modification (GO:0000154)3.51652317
69ribonucleoside triphosphate biosynthetic process (GO:0009201)3.51102737
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.50377379
71protein complex biogenesis (GO:0070271)3.47800959
72oxidative phosphorylation (GO:0006119)3.47301968
73cullin deneddylation (GO:0010388)3.46941332
74exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.44477628
75L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.44395332
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.42493579
77protein deneddylation (GO:0000338)3.42417208
78pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.42394300
79respiratory electron transport chain (GO:0022904)3.41402703
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.40535238
81signal transduction involved in DNA integrity checkpoint (GO:0072401)3.40535238
82protein targeting to mitochondrion (GO:0006626)3.39728394
83rRNA metabolic process (GO:0016072)3.39070887
84intracellular protein transmembrane import (GO:0044743)3.38633463
85respiratory chain complex IV assembly (GO:0008535)3.37048500
86mRNA catabolic process (GO:0006402)3.35559537
87chaperone-mediated protein transport (GO:0072321)3.35519898
88proton transport (GO:0015992)3.35498011
89mitochondrial respiratory chain complex assembly (GO:0033108)3.35377840
90signal transduction involved in cell cycle checkpoint (GO:0072395)3.35235303
91tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.34767192
92RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.34767192
93mitochondrial transport (GO:0006839)3.32994999
94electron transport chain (GO:0022900)3.32943198
95establishment of protein localization to mitochondrion (GO:0072655)3.31366748
96DNA replication initiation (GO:0006270)3.31233715
97chromatin remodeling at centromere (GO:0031055)3.30810799
98hydrogen transport (GO:0006818)3.29077197
99spliceosomal complex assembly (GO:0000245)3.24767584
100peptidyl-histidine modification (GO:0018202)3.24645215
101transcription-coupled nucleotide-excision repair (GO:0006283)3.23046464
1027-methylguanosine mRNA capping (GO:0006370)3.22592679
103aerobic respiration (GO:0009060)3.21066770
104pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.20963301
105establishment of protein localization to mitochondrial membrane (GO:0090151)3.20141736
106nucleoside triphosphate biosynthetic process (GO:0009142)3.19858881
107RNA capping (GO:0036260)3.19056483
1087-methylguanosine RNA capping (GO:0009452)3.19056483
109water-soluble vitamin biosynthetic process (GO:0042364)3.17997401
110mitotic recombination (GO:0006312)3.17758212
111RNA catabolic process (GO:0006401)3.17683949
112positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.17456973
113purine nucleoside monophosphate biosynthetic process (GO:0009127)3.17435684
114purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.17435684
115CENP-A containing nucleosome assembly (GO:0034080)3.17367663
116deoxyribose phosphate biosynthetic process (GO:0046385)3.16570698
1172-deoxyribonucleotide biosynthetic process (GO:0009265)3.16570698
118GTP biosynthetic process (GO:0006183)3.14574903
119DNA replication checkpoint (GO:0000076)3.12421720
120positive regulation of ligase activity (GO:0051351)3.10066089
121pyrimidine nucleotide catabolic process (GO:0006244)3.08479447
122establishment of viral latency (GO:0019043)3.08362662
123aldehyde catabolic process (GO:0046185)3.08138574
124telomere maintenance via telomere lengthening (GO:0010833)3.07207137
125viral mRNA export from host cell nucleus (GO:0046784)3.01997039
126deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.96639184
127protein-cofactor linkage (GO:0018065)2.93028407
128DNA damage response, detection of DNA damage (GO:0042769)2.92689145
129ubiquinone biosynthetic process (GO:0006744)2.86333358
130base-excision repair, AP site formation (GO:0006285)2.83444637
131UTP biosynthetic process (GO:0006228)2.79931050
132protein targeting (GO:0006605)2.79577232
133ribonucleoside monophosphate biosynthetic process (GO:0009156)2.77820931
134pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.77610884

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.74275921
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.33692687
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.26876474
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.19275385
5SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.01966013
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.90093119
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.78011269
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.65577425
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.43892516
10HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.19432238
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.18997073
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.17212521
13NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.05136820
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.87226541
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81124915
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75630522
17CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.71574396
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.62459496
19VDR_23849224_ChIP-Seq_CD4+_Human2.56107136
20XRN2_22483619_ChIP-Seq_HELA_Human2.55260060
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.53955341
22E2F1_18555785_ChIP-Seq_MESCs_Mouse2.33780823
23DCP1A_22483619_ChIP-Seq_HELA_Human2.30361982
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.25890587
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.24240712
26SRF_21415370_ChIP-Seq_HL-1_Mouse2.23539278
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21877618
28FOXP3_21729870_ChIP-Seq_TREG_Human2.21169698
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17276755
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.08332020
31E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.07660285
32GABP_19822575_ChIP-Seq_HepG2_Human2.06753765
33TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04398149
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.02654744
35TTF2_22483619_ChIP-Seq_HELA_Human2.02467616
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.97276145
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.88126166
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81161655
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.80951407
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.78884284
41ELK1_19687146_ChIP-ChIP_HELA_Human1.78695175
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.75032159
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.72607854
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.70708269
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62059609
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55414323
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52501400
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52442392
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51306960
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49486533
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48838068
52MYCN_18555785_ChIP-Seq_MESCs_Mouse1.46983452
53CIITA_25753668_ChIP-Seq_RAJI_Human1.46742052
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46042463
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45823394
56FOXM1_23109430_ChIP-Seq_U2OS_Human1.44730615
57MYC_18940864_ChIP-ChIP_HL60_Human1.40665475
58ZNF274_21170338_ChIP-Seq_K562_Hela1.38332087
59YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36954166
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34677287
61BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.31090649
62IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26864856
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.26482586
64VDR_22108803_ChIP-Seq_LS180_Human1.25924903
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.25468971
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24019301
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.22729125
68HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21223657
69SPI1_23547873_ChIP-Seq_NB4_Human1.20800355
70CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.17200287
71EWS_26573619_Chip-Seq_HEK293_Human1.15416926
72CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15361362
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15233740
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.13618932
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11672702
76FUS_26573619_Chip-Seq_HEK293_Human1.11192602
77NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.09803997
78MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08022449
79KDM5A_27292631_Chip-Seq_BREAST_Human1.07938395
80CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06962485
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.06843332
82VDR_21846776_ChIP-Seq_THP-1_Human1.06560766
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05204639
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.04477809
85ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03335295
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01972649
87TP53_22573176_ChIP-Seq_HFKS_Human1.01971152
88CTCF_18555785_ChIP-Seq_MESCs_Mouse1.00594827
89IRF1_19129219_ChIP-ChIP_H3396_Human1.00382794
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99310723
91AR_21909140_ChIP-Seq_LNCAP_Human0.99231719
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.98899146
93CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97226865
94SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.95703958
95TFEB_21752829_ChIP-Seq_HELA_Human0.95010088
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94634818
97STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93851628
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92881828
99TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.92685371
100HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92225863
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90115238
102HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.89380614
103SRY_22984422_ChIP-ChIP_TESTIS_Rat0.88528593
104PADI4_21655091_ChIP-ChIP_MCF-7_Human0.87474397
105MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87447114
106MYC_22102868_ChIP-Seq_BL_Human0.87444953
107FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87418391
108FOXP1_21924763_ChIP-Seq_HESCs_Human0.86393189
109STAT4_19710469_ChIP-ChIP_TH1__Mouse0.86108527
110POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.85274380
111KLF4_18555785_ChIP-Seq_MESCs_Mouse0.85199596
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83711194
113PU.1_20513432_ChIP-Seq_Bcells_Mouse0.82512459
114FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.80987174
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.80410287
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80340289
117IRF8_22096565_ChIP-ChIP_GC-B_Human0.80287626
118IRF8_21731497_ChIP-ChIP_J774_Mouse0.79719278
119PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.79704686
120EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.77064145
121MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.76635094
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.76524581
123IGF1R_20145208_ChIP-Seq_DFB_Human0.73260784
124PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71412986
125SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70737553
126FLI1_27457419_Chip-Seq_LIVER_Mouse0.68380648
127BMI1_23680149_ChIP-Seq_NPCS_Mouse0.66579033
128SOX17_20123909_ChIP-Seq_XEN_Mouse0.65024969
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.65009440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.44433889
2MP0009379_abnormal_foot_pigmentation3.78850429
3MP0004957_abnormal_blastocyst_morpholog3.53360343
4MP0003186_abnormal_redox_activity2.99830822
5MP0003077_abnormal_cell_cycle2.97971299
6MP0010094_abnormal_chromosome_stability2.83204164
7MP0002837_dystrophic_cardiac_calcinosis2.80126220
8MP0008058_abnormal_DNA_repair2.70335173
9MP0003111_abnormal_nucleus_morphology2.51923507
10MP0004145_abnormal_muscle_electrophysio2.48100415
11MP0006036_abnormal_mitochondrial_physio2.46691360
12MP0003806_abnormal_nucleotide_metabolis2.44933536
13MP0002396_abnormal_hematopoietic_system2.44260726
14MP0001835_abnormal_antigen_presentation2.43951618
15MP0009333_abnormal_splenocyte_physiolog2.43662378
16MP0008007_abnormal_cellular_replicative2.41873950
17MP0008932_abnormal_embryonic_tissue2.18161243
18MP0002132_abnormal_respiratory_system2.15838532
19MP0003787_abnormal_imprinting2.12063252
20MP0008057_abnormal_DNA_replication2.03527469
21MP0006072_abnormal_retinal_apoptosis1.99854635
22MP0003136_yellow_coat_color1.98300167
23MP0000490_abnormal_crypts_of1.96293071
24MP0002148_abnormal_hypersensitivity_rea1.90466247
25MP0006292_abnormal_olfactory_placode1.90347001
26MP0003786_premature_aging1.83879571
27MP0009785_altered_susceptibility_to1.83822254
28MP0005671_abnormal_response_to1.76927318
29MP0006035_abnormal_mitochondrial_morpho1.75827049
30MP0003718_maternal_effect1.74940526
31MP0003646_muscle_fatigue1.71138810
32MP0001853_heart_inflammation1.70879734
33MP0001529_abnormal_vocalization1.69876963
34MP0003763_abnormal_thymus_physiology1.65541575
35MP0002736_abnormal_nociception_after1.63872128
36MP0002638_abnormal_pupillary_reflex1.61809527
37MP0001293_anophthalmia1.60871176
38MP0003121_genomic_imprinting1.58637738
39MP0005075_abnormal_melanosome_morpholog1.58062465
40MP0003724_increased_susceptibility_to1.56912573
41MP0002398_abnormal_bone_marrow1.52029544
42MP0001984_abnormal_olfaction1.51653204
43MP0000685_abnormal_immune_system1.49697595
44MP0002653_abnormal_ependyma_morphology1.48304695
45MP0006276_abnormal_autonomic_nervous1.47982163
46MP0003656_abnormal_erythrocyte_physiolo1.45254154
47MP0005025_abnormal_response_to1.44211081
48MP0001986_abnormal_taste_sensitivity1.43493443
49MP0003436_decreased_susceptibility_to1.42509494
50MP0004147_increased_porphyrin_level1.42434678
51MP0005499_abnormal_olfactory_system1.41911269
52MP0005394_taste/olfaction_phenotype1.41911269
53MP0001968_abnormal_touch/_nociception1.40783788
54MP0000689_abnormal_spleen_morphology1.40428510
55MP0001800_abnormal_humoral_immune1.39944495
56MP0005000_abnormal_immune_tolerance1.37681355
57MP0010030_abnormal_orbit_morphology1.37050862
58MP0000313_abnormal_cell_death1.37023076
59MP0002722_abnormal_immune_system1.36853468
60MP0003123_paternal_imprinting1.34613530
61MP0002420_abnormal_adaptive_immunity1.34144197
62MP0005551_abnormal_eye_electrophysiolog1.34129593
63MP0002429_abnormal_blood_cell1.32455829
64MP0002723_abnormal_immune_serum1.32171569
65MP0001819_abnormal_immune_cell1.32131010
66MP0006054_spinal_hemorrhage1.31335664
67MP0002234_abnormal_pharynx_morphology1.31051679
68MP0005084_abnormal_gallbladder_morpholo1.31023756
69MP0003941_abnormal_skin_development1.30784631
70MP0002452_abnormal_antigen_presenting1.29842584
71MP0009046_muscle_twitch1.28976641
72MP0000716_abnormal_immune_system1.28366417
73MP0001545_abnormal_hematopoietic_system1.26250622
74MP0005397_hematopoietic_system_phenotyp1.26250622
75MP0003122_maternal_imprinting1.25925682
76MP0002019_abnormal_tumor_incidence1.25513746
77MP0004215_abnormal_myocardial_fiber1.25256907
78MP0003880_abnormal_central_pattern1.21844620
79MP0005645_abnormal_hypothalamus_physiol1.21768751
80MP0004142_abnormal_muscle_tone1.20896387
81MP0005253_abnormal_eye_physiology1.19624262
82MP0001764_abnormal_homeostasis1.18838739
83MP0000350_abnormal_cell_proliferation1.18741022
84MP0002272_abnormal_nervous_system1.17063422
85MP0000358_abnormal_cell_content/1.16883535
86MP0000631_abnormal_neuroendocrine_gland1.14204160
87MP0002405_respiratory_system_inflammati1.13386329
88MP0003137_abnormal_impulse_conducting1.12390824
89MP0001730_embryonic_growth_arrest1.12013119
90MP0005646_abnormal_pituitary_gland1.10488214
91MP0004133_heterotaxia1.08662486
92MP0005174_abnormal_tail_pigmentation1.08488481
93MP0008995_early_reproductive_senescence1.08062308
94MP0005379_endocrine/exocrine_gland_phen1.07178616
95MP0000703_abnormal_thymus_morphology1.05828804
96MP0002822_catalepsy1.05620231
97MP0004808_abnormal_hematopoietic_stem1.05177286
98MP0001188_hyperpigmentation1.04934010
99MP0002419_abnormal_innate_immunity1.04518948
100MP0001905_abnormal_dopamine_level1.02848311
101MP0000343_altered_response_to1.02230698
102MP0005332_abnormal_amino_acid1.01551041
103MP0000372_irregular_coat_pigmentation0.99090178
104MP0002734_abnormal_mechanical_nocicepti0.99087796
105MP0008469_abnormal_protein_level0.97200813
106MP0003283_abnormal_digestive_organ0.96545296
107MP0002160_abnormal_reproductive_system0.94720439
108MP0001485_abnormal_pinna_reflex0.94297457
109MP0002095_abnormal_skin_pigmentation0.93185956
110MP0009745_abnormal_behavioral_response0.91398804
111MP0001790_abnormal_immune_system0.90325539
112MP0005387_immune_system_phenotype0.90325539
113MP0002102_abnormal_ear_morphology0.89569345
114MP0002210_abnormal_sex_determination0.87596033
115MP0000858_altered_metastatic_potential0.86382896
116MP0005266_abnormal_metabolism0.85815186
117MP0002277_abnormal_respiratory_mucosa0.85034938
118MP0003567_abnormal_fetal_cardiomyocyte0.84410566
119MP0008877_abnormal_DNA_methylation0.84027300
120MP0002233_abnormal_nose_morphology0.83113564
121MP0001845_abnormal_inflammatory_respons0.82715551
122MP0002090_abnormal_vision0.82077929
123MP0002163_abnormal_gland_morphology0.82044414
124MP0005408_hypopigmentation0.81804373
125MP0001697_abnormal_embryo_size0.81763555
126MP0001727_abnormal_embryo_implantation0.81620677
127MP0002735_abnormal_chemical_nociception0.81248723
128MP0002080_prenatal_lethality0.81175061
129MP0003315_abnormal_perineum_morphology0.80521069
130MP0009697_abnormal_copulation0.79400098
131MP0003011_delayed_dark_adaptation0.79113239
132MP0008872_abnormal_physiological_respon0.77617733
133MP0003937_abnormal_limbs/digits/tail_de0.77090742
134MP0000749_muscle_degeneration0.75988602
135MP0005389_reproductive_system_phenotype0.75684798
136MP0005636_abnormal_mineral_homeostasis0.75551804
137MP0001145_abnormal_male_reproductive0.74929788
138MP0002876_abnormal_thyroid_physiology0.74921242
139MP0001486_abnormal_startle_reflex0.74892197
140MP0003221_abnormal_cardiomyocyte_apopto0.74196689
141MP0005670_abnormal_white_adipose0.74060038
142MP0005195_abnormal_posterior_eye0.73778066
143MP0001929_abnormal_gametogenesis0.73774595
144MP0000653_abnormal_sex_gland0.73186917
145MP0000465_gastrointestinal_hemorrhage0.71997475
146MP0000015_abnormal_ear_pigmentation0.71669228
147MP0000049_abnormal_middle_ear0.71327446
148MP0001970_abnormal_pain_threshold0.70951061
149MP0010155_abnormal_intestine_physiology0.70330632
150MP0002938_white_spotting0.69991826
151MP0002733_abnormal_thermal_nociception0.69974243
152MP0002752_abnormal_somatic_nervous0.68782262
153MP0008775_abnormal_heart_ventricle0.68582855
154MP0005376_homeostasis/metabolism_phenot0.68468690
155MP0000026_abnormal_inner_ear0.67534064
156MP0008875_abnormal_xenobiotic_pharmacok0.67327514
157MP0005464_abnormal_platelet_physiology0.66436953
158MP0008789_abnormal_olfactory_epithelium0.65723009
159MP0001663_abnormal_digestive_system0.63543042
160MP0010368_abnormal_lymphatic_system0.61785065

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.61760841
2Abnormal number of erythroid precursors (HP:0012131)5.45417280
3Mitochondrial inheritance (HP:0001427)4.97192140
4Hepatocellular necrosis (HP:0001404)4.97083857
5Acute necrotizing encephalopathy (HP:0006965)4.96580358
6Reticulocytopenia (HP:0001896)4.85254764
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.74281099
8Decreased activity of mitochondrial respiratory chain (HP:0008972)4.74281099
9Abnormal mitochondria in muscle tissue (HP:0008316)4.67080132
10Increased hepatocellular lipid droplets (HP:0006565)4.58155448
11Increased CSF lactate (HP:0002490)4.56264295
12Hepatic necrosis (HP:0002605)4.54257617
13Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)4.27244875
14Lipid accumulation in hepatocytes (HP:0006561)4.21839184
15Acute encephalopathy (HP:0006846)4.15586563
16Macrocytic anemia (HP:0001972)3.92378130
173-Methylglutaconic aciduria (HP:0003535)3.89965586
18Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.83926297
19Progressive macrocephaly (HP:0004481)3.83022462
20Increased serum lactate (HP:0002151)3.79479744
21Aplastic anemia (HP:0001915)3.66013324
22Increased intramyocellular lipid droplets (HP:0012240)3.63480459
23Abnormality of glycolysis (HP:0004366)3.62345732
24Increased serum pyruvate (HP:0003542)3.62345732
25Exertional dyspnea (HP:0002875)3.62004555
26Renal Fanconi syndrome (HP:0001994)3.60862015
27Pallor (HP:0000980)3.52314040
28Birth length less than 3rd percentile (HP:0003561)3.34230153
29Lactic acidosis (HP:0003128)3.31684672
30Increased muscle lipid content (HP:0009058)3.21907085
31Type I transferrin isoform profile (HP:0003642)3.17765559
32Respiratory failure (HP:0002878)3.16625376
33Respiratory difficulties (HP:0002880)3.16374618
34Exercise intolerance (HP:0003546)3.15049442
35Microvesicular hepatic steatosis (HP:0001414)3.03520283
36Abnormality of the anterior horn cell (HP:0006802)2.94064436
37Degeneration of anterior horn cells (HP:0002398)2.94064436
38Cerebral edema (HP:0002181)2.93933443
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81132684
40Oral leukoplakia (HP:0002745)2.78607496
41Abnormality of the heme biosynthetic pathway (HP:0010472)2.75564378
42Pancreatic fibrosis (HP:0100732)2.65899289
43Reduced antithrombin III activity (HP:0001976)2.64049718
44Hyperglycinemia (HP:0002154)2.56702357
45Petechiae (HP:0000967)2.51408450
46Cerebral hypomyelination (HP:0006808)2.47504931
47Poor head control (HP:0002421)2.45699055
48Breast hypoplasia (HP:0003187)2.44785516
49Pancreatic cysts (HP:0001737)2.41823786
50Thrombocytosis (HP:0001894)2.37693733
51Rough bone trabeculation (HP:0100670)2.36854589
52CNS demyelination (HP:0007305)2.33764661
53Optic disc pallor (HP:0000543)2.28688425
54Carpal bone hypoplasia (HP:0001498)2.28260572
55Leukodystrophy (HP:0002415)2.28217448
56Pancytopenia (HP:0001876)2.28018947
57Microretrognathia (HP:0000308)2.27006355
58Congenital, generalized hypertrichosis (HP:0004540)2.26693722
59True hermaphroditism (HP:0010459)2.26542972
60Myokymia (HP:0002411)2.24249544
61Muscle fiber atrophy (HP:0100295)2.23362771
62Methylmalonic acidemia (HP:0002912)2.21482206
63Type 2 muscle fiber atrophy (HP:0003554)2.18888472
64Abnormal protein glycosylation (HP:0012346)2.17636109
65Abnormal glycosylation (HP:0012345)2.17636109
66Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.17636109
67Abnormal protein N-linked glycosylation (HP:0012347)2.17636109
68Medial flaring of the eyebrow (HP:0010747)2.16184726
69Emotional lability (HP:0000712)2.16178600
70Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.15926967
71Abnormality of alanine metabolism (HP:0010916)2.15926967
72Hyperalaninemia (HP:0003348)2.15926967
73IgM deficiency (HP:0002850)2.15580782
74Molar tooth sign on MRI (HP:0002419)2.11992370
75Abnormality of midbrain morphology (HP:0002418)2.11992370
76Multiple enchondromatosis (HP:0005701)2.10957652
77Hyperglycinuria (HP:0003108)2.07707910
7811 pairs of ribs (HP:0000878)2.07633290
79Sclerocornea (HP:0000647)2.02845358
80Abnormality of the labia minora (HP:0012880)2.02688188
81Elevated erythrocyte sedimentation rate (HP:0003565)2.02145956
82Septo-optic dysplasia (HP:0100842)2.01677670
83Hypoglycemic coma (HP:0001325)2.01179190
84Abnormality of renal resorption (HP:0011038)1.99132910
85Trismus (HP:0000211)1.96896537
86X-linked dominant inheritance (HP:0001423)1.94443705
87Nephronophthisis (HP:0000090)1.93570588
88Lethargy (HP:0001254)1.91736131
89Hyperinsulinemic hypoglycemia (HP:0000825)1.91343751
90Gliosis (HP:0002171)1.90867090
91Recurrent abscess formation (HP:0002722)1.86412679
92Abnormality of reticulocytes (HP:0004312)1.85069885
93Colon cancer (HP:0003003)1.84436159
94Abnormality of serum amino acid levels (HP:0003112)1.83837781
95Secondary amenorrhea (HP:0000869)1.82373956
96Premature graying of hair (HP:0002216)1.82254606
97Ragged-red muscle fibers (HP:0003200)1.82097954
98Abnormality of serine family amino acid metabolism (HP:0010894)1.81151982
99Abnormality of glycine metabolism (HP:0010895)1.81151982
100Abnormality of dicarboxylic acid metabolism (HP:0010995)1.80426350
101Dicarboxylic aciduria (HP:0003215)1.80426350
102Hyperphosphaturia (HP:0003109)1.79021342
103Neoplasm of head and neck (HP:0012288)1.78783207
104Esophageal neoplasm (HP:0100751)1.78783207
105Aplasia/hypoplasia of the uterus (HP:0008684)1.77541032
106Nemaline bodies (HP:0003798)1.75809691
107Gait imbalance (HP:0002141)1.74434356
108Congenital primary aphakia (HP:0007707)1.73244198
109Abnormality of urine glucose concentration (HP:0011016)1.72576422
110Glycosuria (HP:0003076)1.72576422
111Cleft eyelid (HP:0000625)1.69377792
112Abnormal trabecular bone morphology (HP:0100671)1.69324570
113Maternal diabetes (HP:0009800)1.69264894
114Muscle fiber inclusion bodies (HP:0100299)1.68417774
115Blindness (HP:0000618)1.67933610
116Absent thumb (HP:0009777)1.67207068
117Nausea (HP:0002018)1.66050919
118Poor suck (HP:0002033)1.65647259
119Generalized aminoaciduria (HP:0002909)1.64335123
120Agnosia (HP:0010524)1.64176202
121Bone marrow hypocellularity (HP:0005528)1.63838167
122Sparse eyelashes (HP:0000653)1.63109704
123Vomiting (HP:0002013)1.62900149
124Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.61824649
125Nephrogenic diabetes insipidus (HP:0009806)1.61027672
126Recurrent bacterial skin infections (HP:0005406)1.60002643
127Progressive muscle weakness (HP:0003323)1.59430660
128Increased serum ferritin (HP:0003281)1.59367196
129Neutropenia (HP:0001875)1.57716447
130Anencephaly (HP:0002323)1.57542011
131Hypoglycemic seizures (HP:0002173)1.55998800
132Rib fusion (HP:0000902)1.55814096
133Methylmalonic aciduria (HP:0012120)1.55119538
134Cellular immunodeficiency (HP:0005374)1.54172634
135Tongue fasciculations (HP:0001308)1.53888498

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.61015214
2NME24.72945818
3BUB14.66657448
4STK163.74335114
5TLK13.30096906
6EIF2AK13.16286001
7WEE13.04420694
8PIM22.63272233
9VRK12.48214523
10EIF2AK32.18974732
11TESK22.14740423
12NUAK12.11020747
13BMPR1B2.01812067
14SRPK12.00221751
15WNK31.97613271
16OBSCN1.86172290
17BCKDK1.79422176
18DYRK31.77066792
19TAF11.76701783
20NME11.75890235
21CDC71.67981800
22KDR1.64004806
23ARAF1.55299379
24CDK191.49092398
25PHKG11.47801769
26PHKG21.47801769
27MAP4K21.45423942
28CSNK1G31.43406316
29IRAK41.40008697
30PLK41.38378845
31CSNK1G21.36851638
32PASK1.34277102
33CSNK1G11.32678083
34BRSK21.32229987
35CDK81.24767392
36MAP4K11.24749075
37MKNK11.24673829
38BLK1.21484007
39CDK71.20872532
40MAP3K111.19586017
41INSRR1.19068539
42PBK1.18299657
43TTK1.16975961
44TSSK61.16051984
45GRK11.13865595
46MAP3K121.12234411
47RPS6KA41.11799015
48SCYL21.11419279
49TEC1.10905875
50PAK41.06033406
51MST41.06008264
52PINK11.05551433
53KIT1.05182162
54CCNB11.04690101
55MAP2K71.03921903
56BTK1.02864906
57BRAF1.02401005
58PLK11.02346566
59PDK21.02122328
60ADRBK20.99932109
61ABL20.98384510
62TESK10.96741365
63AURKA0.93503926
64AURKB0.92553450
65LIMK10.92496316
66TBK10.92328887
67ILK0.91672272
68CSNK1A1L0.84955220
69TIE10.83804023
70IRAK30.83725770
71ZAP700.82552713
72MAP3K40.82407103
73PIM10.80256804
74FLT30.80220377
75CSNK2A10.79544827
76SYK0.79189751
77ATR0.78894221
78GRK70.77416552
79BRSK10.76079776
80ACVR1B0.75430156
81OXSR10.74090937
82MYLK0.73946769
83MKNK20.72759629
84TXK0.72669571
85RPS6KB20.71926492
86CAMKK20.70813455
87PRKCG0.69818374
88TYK20.68937886
89CSNK2A20.68855046
90DYRK20.68729314
91ZAK0.66994452
92GRK60.66829969
93LRRK20.66202086
94PAK10.66159953
95NEK10.64516879
96EIF2AK20.64385370
97LYN0.63678701
98IKBKB0.63401768
99RPS6KA50.63006582
100TNIK0.61375831
101MAP2K30.60809049
102RAF10.58588206
103MAPK130.57508050
104MOS0.57067102
105MUSK0.56964654
106CSF1R0.56174884
107FRK0.55373751
108TGFBR10.55339594
109IKBKE0.53618102
110GRK50.52835498
111CSNK1E0.50512982
112CLK10.49909851
113PLK20.49869989
114DAPK30.49112273
115MAP3K80.48277511
116STK240.48244710
117CHEK20.46964925
118TAOK20.46754136
119SIK30.46310765
120CSNK1A10.46255820
121MAPKAPK50.44322556
122PRKCI0.44226110
123NLK0.43996639
124STK40.43866543
125DAPK10.43825680
126NEK20.43714838
127PRKACA0.43380295
128PLK30.43328614
129RPS6KA60.42439271
130CAMK2A0.41834028
131CDK40.40836009
132CASK0.39087054
133ADRBK10.38517617
134CAMK2D0.37065881
135PRKCE0.36539616
136WNK40.35892015
137ATM0.35520678
138PIK3CG0.33731994
139CAMK2G0.32094456

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.56728954
2Proteasome_Homo sapiens_hsa030504.43400170
3DNA replication_Homo sapiens_hsa030303.95609868
4RNA polymerase_Homo sapiens_hsa030203.46762766
5Oxidative phosphorylation_Homo sapiens_hsa001903.23252222
6Parkinsons disease_Homo sapiens_hsa050123.02209197
7Mismatch repair_Homo sapiens_hsa034302.99705108
8Spliceosome_Homo sapiens_hsa030402.73514067
9Pyrimidine metabolism_Homo sapiens_hsa002402.62757099
10Protein export_Homo sapiens_hsa030602.59500495
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.49146619
12Base excision repair_Homo sapiens_hsa034102.44846422
13Homologous recombination_Homo sapiens_hsa034402.43361933
14Nucleotide excision repair_Homo sapiens_hsa034202.31457186
15Huntingtons disease_Homo sapiens_hsa050162.24114887
16Alzheimers disease_Homo sapiens_hsa050101.92248521
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.87336631
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.86392477
19RNA transport_Homo sapiens_hsa030131.83065697
20Folate biosynthesis_Homo sapiens_hsa007901.50834550
21RNA degradation_Homo sapiens_hsa030181.47907245
22Fanconi anemia pathway_Homo sapiens_hsa034601.45665308
23Basal transcription factors_Homo sapiens_hsa030221.45533298
24One carbon pool by folate_Homo sapiens_hsa006701.42986237
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42504605
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.37307816
27Purine metabolism_Homo sapiens_hsa002301.35818316
28Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32155464
29Non-homologous end-joining_Homo sapiens_hsa034501.31989129
30Sulfur relay system_Homo sapiens_hsa041221.26848124
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26455583
32Cell cycle_Homo sapiens_hsa041101.20265363
33Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.10734083
34Sulfur metabolism_Homo sapiens_hsa009201.01772732
35Cysteine and methionine metabolism_Homo sapiens_hsa002700.99111417
36Glutathione metabolism_Homo sapiens_hsa004800.98946484
37Butanoate metabolism_Homo sapiens_hsa006500.97295664
38Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96563564
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84150139
40Phototransduction_Homo sapiens_hsa047440.83998385
41Cardiac muscle contraction_Homo sapiens_hsa042600.83105891
42Epstein-Barr virus infection_Homo sapiens_hsa051690.82780130
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80884952
44Primary immunodeficiency_Homo sapiens_hsa053400.75185094
45Drug metabolism - other enzymes_Homo sapiens_hsa009830.71959574
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70559371
47Nitrogen metabolism_Homo sapiens_hsa009100.70018507
48Tryptophan metabolism_Homo sapiens_hsa003800.69981538
49Pentose phosphate pathway_Homo sapiens_hsa000300.68411771
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.67244662
51Carbon metabolism_Homo sapiens_hsa012000.67069652
52Metabolic pathways_Homo sapiens_hsa011000.66730169
53Systemic lupus erythematosus_Homo sapiens_hsa053220.66431719
54p53 signaling pathway_Homo sapiens_hsa041150.66173391
55Biosynthesis of amino acids_Homo sapiens_hsa012300.65905609
56Fatty acid degradation_Homo sapiens_hsa000710.64799325
57Herpes simplex infection_Homo sapiens_hsa051680.63827009
58Collecting duct acid secretion_Homo sapiens_hsa049660.63673869
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63027974
60Antigen processing and presentation_Homo sapiens_hsa046120.61957745
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.61436387
62Legionellosis_Homo sapiens_hsa051340.60233670
63Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59527679
64Pyruvate metabolism_Homo sapiens_hsa006200.58143335
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.56541386
66mRNA surveillance pathway_Homo sapiens_hsa030150.54830335
67Nicotine addiction_Homo sapiens_hsa050330.50917957
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.50699402
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48824239
70Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47120226
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45869488
72Allograft rejection_Homo sapiens_hsa053300.43157002
73Fatty acid metabolism_Homo sapiens_hsa012120.43144835
74Linoleic acid metabolism_Homo sapiens_hsa005910.41969520
75Arachidonic acid metabolism_Homo sapiens_hsa005900.41238941
76Fatty acid elongation_Homo sapiens_hsa000620.40672086
77Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39357085
78Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.38245931
79Vitamin B6 metabolism_Homo sapiens_hsa007500.37688416
80N-Glycan biosynthesis_Homo sapiens_hsa005100.36063848
81Arginine and proline metabolism_Homo sapiens_hsa003300.35939587
82Peroxisome_Homo sapiens_hsa041460.35916690
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.35727006
84Selenocompound metabolism_Homo sapiens_hsa004500.34958952
85Propanoate metabolism_Homo sapiens_hsa006400.34621800
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34605646
87Shigellosis_Homo sapiens_hsa051310.34514134
88Asthma_Homo sapiens_hsa053100.34337930
89Graft-versus-host disease_Homo sapiens_hsa053320.34228361
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.33755899
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.33578691
92Fructose and mannose metabolism_Homo sapiens_hsa000510.32574240
93Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.32203568
94Leishmaniasis_Homo sapiens_hsa051400.31589544
95Measles_Homo sapiens_hsa051620.30233411
96Galactose metabolism_Homo sapiens_hsa000520.27520347
97Regulation of autophagy_Homo sapiens_hsa041400.26134631
98Hematopoietic cell lineage_Homo sapiens_hsa046400.25995584
99Steroid biosynthesis_Homo sapiens_hsa001000.25873265
100Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.25430127
101Other glycan degradation_Homo sapiens_hsa005110.25064366
102Alcoholism_Homo sapiens_hsa050340.24999288
103Retinol metabolism_Homo sapiens_hsa008300.24928173
104Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24750298
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24562250
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24153279
107Phenylalanine metabolism_Homo sapiens_hsa003600.23775466
108Pertussis_Homo sapiens_hsa051330.23628095
109Basal cell carcinoma_Homo sapiens_hsa052170.22483241
110Thyroid cancer_Homo sapiens_hsa052160.22396144
111Oocyte meiosis_Homo sapiens_hsa041140.21147955
112Primary bile acid biosynthesis_Homo sapiens_hsa001200.20868366
113Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20151837
114Fat digestion and absorption_Homo sapiens_hsa049750.19789033
115Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19751476
116Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19515260
117Vitamin digestion and absorption_Homo sapiens_hsa049770.18918341
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.18385301
119Tyrosine metabolism_Homo sapiens_hsa003500.17813383
120Viral carcinogenesis_Homo sapiens_hsa052030.17082537
121Arginine biosynthesis_Homo sapiens_hsa002200.16639623
122Apoptosis_Homo sapiens_hsa042100.14418733
123Vibrio cholerae infection_Homo sapiens_hsa051100.14296504
124NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14181861
125Chemical carcinogenesis_Homo sapiens_hsa052040.11711209
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.11421497
127Autoimmune thyroid disease_Homo sapiens_hsa053200.11163345
128Rheumatoid arthritis_Homo sapiens_hsa053230.11010876
129beta-Alanine metabolism_Homo sapiens_hsa004100.10827155
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.10686313
131Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.10648824

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