TMEM25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of synapse maturation (GO:0090129)5.44292276
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.92142477
3L-phenylalanine catabolic process (GO:0006559)4.92142477
4L-phenylalanine metabolic process (GO:0006558)4.60303859
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.60303859
6regulation of synapse maturation (GO:0090128)4.50983728
7aromatic amino acid family catabolic process (GO:0009074)4.11277966
8establishment of mitochondrion localization (GO:0051654)3.97945106
9postsynaptic membrane organization (GO:0001941)3.97487033
10gamma-aminobutyric acid transport (GO:0015812)3.94990991
11layer formation in cerebral cortex (GO:0021819)3.91399436
12pyrimidine nucleobase catabolic process (GO:0006208)3.89687687
13axonal fasciculation (GO:0007413)3.88432589
14neuronal action potential propagation (GO:0019227)3.86217779
15glutamate secretion (GO:0014047)3.81563924
16synaptic vesicle exocytosis (GO:0016079)3.68985644
17regulation of short-term neuronal synaptic plasticity (GO:0048172)3.65019593
18nucleobase catabolic process (GO:0046113)3.63812353
19glutamate metabolic process (GO:0006536)3.62977849
20dicarboxylic acid biosynthetic process (GO:0043650)3.56393145
21dendritic spine morphogenesis (GO:0060997)3.54739956
22tryptophan catabolic process (GO:0006569)3.51429946
23indole-containing compound catabolic process (GO:0042436)3.51429946
24indolalkylamine catabolic process (GO:0046218)3.51429946
25kynurenine metabolic process (GO:0070189)3.50405111
26cellular ketone body metabolic process (GO:0046950)3.49016647
27bile acid biosynthetic process (GO:0006699)3.47097920
28neuron recognition (GO:0008038)3.46668613
29coenzyme catabolic process (GO:0009109)3.45558978
30neurotransmitter secretion (GO:0007269)3.45236705
31regulation of synaptic vesicle exocytosis (GO:2000300)3.41386390
32triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.40713494
33regulation of synapse structural plasticity (GO:0051823)3.36806247
34vocalization behavior (GO:0071625)3.34090385
35synaptic vesicle maturation (GO:0016188)3.31925617
36positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29382050
37lysine catabolic process (GO:0006554)3.29205247
38lysine metabolic process (GO:0006553)3.29205247
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.28427159
40mitochondrion transport along microtubule (GO:0047497)3.28427159
41neurotransmitter-gated ion channel clustering (GO:0072578)3.25933290
42tryptophan metabolic process (GO:0006568)3.25596775
43positive regulation of membrane potential (GO:0045838)3.25342366
44neuromuscular process controlling posture (GO:0050884)3.23835505
45high-density lipoprotein particle remodeling (GO:0034375)3.22346078
46neuronal ion channel clustering (GO:0045161)3.20914995
47glyoxylate metabolic process (GO:0046487)3.19870740
48positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.17029903
49cell migration in hindbrain (GO:0021535)3.16484810
50auditory behavior (GO:0031223)3.16264861
51central nervous system projection neuron axonogenesis (GO:0021952)3.15057293
52cysteine metabolic process (GO:0006534)3.14354456
53aspartate family amino acid catabolic process (GO:0009068)3.13732737
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.12968876
55dicarboxylic acid catabolic process (GO:0043649)3.12302564
56regulation of synaptic vesicle transport (GO:1902803)3.04267953
57ketone body metabolic process (GO:1902224)3.01937825
58synapse assembly (GO:0007416)3.01450633
59presynaptic membrane assembly (GO:0097105)2.99883512
60presynaptic membrane organization (GO:0097090)2.99231754
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99124272
62locomotory exploration behavior (GO:0035641)2.98848152
63alpha-amino acid catabolic process (GO:1901606)2.97896448
64regulation of dendritic spine morphogenesis (GO:0061001)2.97430342
65positive regulation of dendritic spine morphogenesis (GO:0061003)2.94886061
66alpha-linolenic acid metabolic process (GO:0036109)2.94840699
67regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.94778080
68behavioral response to nicotine (GO:0035095)2.94285317
69aromatic amino acid family metabolic process (GO:0009072)2.93988626
70bile acid metabolic process (GO:0008206)2.93958494
71urea cycle (GO:0000050)2.93531523
72urea metabolic process (GO:0019627)2.93531523
73positive regulation of dendritic spine development (GO:0060999)2.89859835
74transmission of nerve impulse (GO:0019226)2.89377414
75drug catabolic process (GO:0042737)2.88079687
76dendritic spine organization (GO:0097061)2.87077211
77succinate metabolic process (GO:0006105)2.86799974
78tyrosine metabolic process (GO:0006570)2.86470059
79membrane depolarization during action potential (GO:0086010)2.85918858
80oxaloacetate metabolic process (GO:0006107)2.84642047
81regulation of neurotransmitter secretion (GO:0046928)2.84346754
82protein localization to synapse (GO:0035418)2.84085175
83retinal cone cell development (GO:0046549)2.83699157
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.83644365
85neuromuscular synaptic transmission (GO:0007274)2.82546410
86neurotransmitter transport (GO:0006836)2.82028403
87sulfur amino acid catabolic process (GO:0000098)2.81901751
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.81584452
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.81513056
90regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81226184
91regulation of vesicle fusion (GO:0031338)2.81144098
92regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81081434
93reverse cholesterol transport (GO:0043691)2.81061043
94cellular modified amino acid catabolic process (GO:0042219)2.80255846
95cellular amino acid catabolic process (GO:0009063)2.79606822
96regulation of glutamate receptor signaling pathway (GO:1900449)2.79390254
97negative regulation of fibrinolysis (GO:0051918)2.78176473
98regulation of postsynaptic membrane potential (GO:0060078)2.77727215
99regulation of dendritic spine development (GO:0060998)2.76880163
100exploration behavior (GO:0035640)2.76609341
101glycosphingolipid biosynthetic process (GO:0006688)2.75962119
102neuron cell-cell adhesion (GO:0007158)2.74629575
103regulation of fibrinolysis (GO:0051917)2.74540814
104regulation of neuronal synaptic plasticity (GO:0048168)2.74448253
105proline transport (GO:0015824)2.74385174
106regulation of calcium ion-dependent exocytosis (GO:0017158)2.73925821
107exogenous drug catabolic process (GO:0042738)2.73285248
108serine family amino acid catabolic process (GO:0009071)2.71963651
109regulation of voltage-gated calcium channel activity (GO:1901385)2.71303213
110nitrogen cycle metabolic process (GO:0071941)2.71254499
111plasma lipoprotein particle remodeling (GO:0034369)2.70306960
112protein-lipid complex remodeling (GO:0034368)2.70306960
113macromolecular complex remodeling (GO:0034367)2.70306960
114regulation of neurotransmitter levels (GO:0001505)2.70057606
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.69807154
116regulation of cholesterol esterification (GO:0010872)2.69763099
117substrate-independent telencephalic tangential migration (GO:0021826)2.69331132
118substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.69331132
119cerebellar granule cell differentiation (GO:0021707)2.68606228
120synaptic transmission, glutamatergic (GO:0035249)2.68408588
121regulation of protein activation cascade (GO:2000257)2.68151425
122short-chain fatty acid metabolic process (GO:0046459)2.67976471
123neuron-neuron synaptic transmission (GO:0007270)2.67572309
124regulation of neurotransmitter transport (GO:0051588)2.66693576
125ionotropic glutamate receptor signaling pathway (GO:0035235)2.66205837
126cerebellar Purkinje cell differentiation (GO:0021702)2.65387026
127negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63228008
128startle response (GO:0001964)2.62503704
129membrane depolarization (GO:0051899)2.62232319
130homocysteine metabolic process (GO:0050667)2.61376947
131axon ensheathment in central nervous system (GO:0032291)2.61303017
132central nervous system myelination (GO:0022010)2.61303017
133cofactor catabolic process (GO:0051187)2.61283005
134synapse organization (GO:0050808)2.59326053
135regulation of G0 to G1 transition (GO:0070316)2.58509234
136gamma-aminobutyric acid signaling pathway (GO:0007214)2.58496853
137fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.58280660
138peroxisome fission (GO:0016559)2.58275879
139cellular potassium ion homeostasis (GO:0030007)2.57702812
140peptidyl-glutamic acid carboxylation (GO:0017187)2.56812328
141protein carboxylation (GO:0018214)2.56812328
142NADH metabolic process (GO:0006734)2.56127049
143acetyl-CoA metabolic process (GO:0006084)2.55952346
144positive regulation of dendrite development (GO:1900006)2.54982313
145complement activation, alternative pathway (GO:0006957)2.54619810
146short-term memory (GO:0007614)2.54319234
147glutamate receptor signaling pathway (GO:0007215)2.52919685
148cholesterol efflux (GO:0033344)2.52881155
149chemosensory behavior (GO:0007635)2.52845218
150triglyceride homeostasis (GO:0070328)2.52523841
151acylglycerol homeostasis (GO:0055090)2.52523841
152potassium ion homeostasis (GO:0055075)2.52174639
153regulation of synaptic transmission, glutamatergic (GO:0051966)2.51436007
154regulation of cilium movement (GO:0003352)2.51429320
155indolalkylamine metabolic process (GO:0006586)2.51381168
156regulation of cell communication by electrical coupling (GO:0010649)2.51178576
157positive regulation of mitochondrial fission (GO:0090141)2.49774097
158positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49587063
159sodium ion export (GO:0071436)2.49523779
160cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.49512401
161regulation of bile acid biosynthetic process (GO:0070857)2.49351200
162regulation of microtubule-based movement (GO:0060632)2.48711057
163amino-acid betaine metabolic process (GO:0006577)2.48624995
164calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.48270605
165central nervous system neuron axonogenesis (GO:0021955)2.47856666
166regulation of synapse organization (GO:0050807)2.47623438
167synaptic vesicle endocytosis (GO:0048488)2.47268101
168calcium ion-dependent exocytosis (GO:0017156)2.46400045

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.37712933
2EZH2_22144423_ChIP-Seq_EOC_Human3.67995076
3GBX2_23144817_ChIP-Seq_PC3_Human3.37959425
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.04897405
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52328882
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.49806339
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.48481154
8FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.40893795
9* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.35286800
10REST_21632747_ChIP-Seq_MESCs_Mouse2.29161832
11TAF15_26573619_Chip-Seq_HEK293_Human2.24475640
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.14276685
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10663512
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.07067798
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.04261838
16EZH2_18974828_ChIP-Seq_MESCs_Mouse2.04261838
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.01926866
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.00873488
19REST_18959480_ChIP-ChIP_MESCs_Mouse1.99461999
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96253921
21EGR1_23403033_ChIP-Seq_LIVER_Mouse1.96077035
22DROSHA_22980978_ChIP-Seq_HELA_Human1.95973196
23NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.95069657
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.91807942
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.89899679
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.85967937
27ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.79514328
28RARB_27405468_Chip-Seq_BRAIN_Mouse1.78460815
29EED_16625203_ChIP-ChIP_MESCs_Mouse1.75834809
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.74415967
31EZH2_27304074_Chip-Seq_ESCs_Mouse1.69097260
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.67516105
33MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.64834517
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.56765379
35RNF2_27304074_Chip-Seq_NSC_Mouse1.56210774
36CTBP2_25329375_ChIP-Seq_LNCAP_Human1.56141393
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.51769677
38SMAD4_21799915_ChIP-Seq_A2780_Human1.49106631
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48588444
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.43164652
41TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.43103705
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40078427
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38712213
44ERG_21242973_ChIP-ChIP_JURKAT_Human1.38315696
45HTT_18923047_ChIP-ChIP_STHdh_Human1.36266470
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35840719
47ZFP57_27257070_Chip-Seq_ESCs_Mouse1.32822399
48AR_21572438_ChIP-Seq_LNCaP_Human1.31715647
49P300_19829295_ChIP-Seq_ESCs_Human1.29455580
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27205574
51CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.26837837
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.26801738
53PIAS1_25552417_ChIP-Seq_VCAP_Human1.24972821
54THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.21716425
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.19752514
56PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18969471
57* CTCF_27219007_Chip-Seq_Bcells_Human1.16446966
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16306453
59* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.15810221
60IKZF1_21737484_ChIP-ChIP_HCT116_Human1.15799858
61* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14679345
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14366439
63AR_25329375_ChIP-Seq_VCAP_Human1.12871718
64ZNF274_21170338_ChIP-Seq_K562_Hela1.11138655
65RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11124093
66STAT3_23295773_ChIP-Seq_U87_Human1.08485864
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06454421
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05198939
69FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05142776
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04611649
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.03681491
72SMAD3_21741376_ChIP-Seq_EPCs_Human1.03283932
73OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01848835
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01575021
75TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00814841
76RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98346616
77AR_19668381_ChIP-Seq_PC3_Human0.97671044
78TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96840807
79POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96340559
80OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.96024572
81FOXA2_19822575_ChIP-Seq_HepG2_Human0.96009754
82MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95925566
83TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95277175
84VDR_22108803_ChIP-Seq_LS180_Human0.95192055
85FUS_26573619_Chip-Seq_HEK293_Human0.95148832
86BMI1_23680149_ChIP-Seq_NPCS_Mouse0.94256010
87* TET1_21490601_ChIP-Seq_MESCs_Mouse0.93702424
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91993906
89CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91792471
90BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91676195
91TCF4_23295773_ChIP-Seq_U87_Human0.91591792
92* CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91080221
93KLF5_20875108_ChIP-Seq_MESCs_Mouse0.90953760
94ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90934792
95CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90249317
96* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90053200
97POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89628190
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89628190
99IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89558868
100CBP_20019798_ChIP-Seq_JUKART_Human0.89558868
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.89529318
102IGF1R_20145208_ChIP-Seq_DFB_Human0.89184655
103BCAT_22108803_ChIP-Seq_LS180_Human0.88890497
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88793380
105SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88538516
106ARNT_22903824_ChIP-Seq_MCF-7_Human0.88421606
107KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87698338
108LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86158623
109AHR_22903824_ChIP-Seq_MCF-7_Human0.85606907
110* SMAD4_21741376_ChIP-Seq_EPCs_Human0.84565367
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.84036519
112MYC_19829295_ChIP-Seq_ESCs_Human0.83914801
113SMAD3_21741376_ChIP-Seq_ESCs_Human0.83395479
114NRF2_20460467_ChIP-Seq_MEFs_Mouse0.83385930
115NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.83385930
116ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82973418
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.82260151
118RUNX2_22187159_ChIP-Seq_PCA_Human0.81811060
119RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.81352782
120* ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80418742
121PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79527708
122P53_22127205_ChIP-Seq_FIBROBLAST_Human0.79472623
123RING1B_27294783_Chip-Seq_ESCs_Mouse0.79012109
124WT1_25993318_ChIP-Seq_PODOCYTE_Human0.78544073
125CBX2_27304074_Chip-Seq_ESCs_Mouse0.77994037
126ER_23166858_ChIP-Seq_MCF-7_Human0.77117988
127KDM2B_26808549_Chip-Seq_REH_Human0.76785334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.49757899
2MP0005360_urolithiasis4.10161049
3MP0004859_abnormal_synaptic_plasticity3.87298042
4MP0005085_abnormal_gallbladder_physiolo3.53630351
5MP0003880_abnormal_central_pattern3.51209969
6MP0005365_abnormal_bile_salt3.21164696
7MP0008875_abnormal_xenobiotic_pharmacok3.16868690
8MP0009046_muscle_twitch2.86954887
9MP0004270_analgesia2.82772559
10MP0003635_abnormal_synaptic_transmissio2.80823613
11MP0009745_abnormal_behavioral_response2.54646102
12MP0002064_seizures2.54474613
13MP0001968_abnormal_touch/_nociception2.45749926
14MP0002735_abnormal_chemical_nociception2.26251270
15MP0002272_abnormal_nervous_system2.22872401
16MP0008789_abnormal_olfactory_epithelium2.22376304
17MP0002736_abnormal_nociception_after2.20842889
18MP0003195_calcinosis2.17627922
19MP0002063_abnormal_learning/memory/cond2.16626898
20MP0005394_taste/olfaction_phenotype2.16582223
21MP0005499_abnormal_olfactory_system2.16582223
22MP0003329_amyloid_beta_deposits2.05623799
23MP0002734_abnormal_mechanical_nocicepti1.98873222
24MP0002572_abnormal_emotion/affect_behav1.98222838
25MP0005083_abnormal_biliary_tract1.96943129
26MP0010329_abnormal_lipoprotein_level1.96507397
27MP0003122_maternal_imprinting1.93789294
28MP0005332_abnormal_amino_acid1.92998741
29MP0003806_abnormal_nucleotide_metabolis1.85973832
30MP0003252_abnormal_bile_duct1.84721055
31MP0001486_abnormal_startle_reflex1.83800973
32MP0002822_catalepsy1.82945314
33MP0001501_abnormal_sleep_pattern1.79365830
34MP0001440_abnormal_grooming_behavior1.71624110
35MP0002067_abnormal_sensory_capabilities1.71057271
36MP0002837_dystrophic_cardiac_calcinosis1.69092490
37MP0006276_abnormal_autonomic_nervous1.67586404
38MP0002733_abnormal_thermal_nociception1.62816096
39MP0005646_abnormal_pituitary_gland1.56706372
40MP0003121_genomic_imprinting1.54625695
41MP0009780_abnormal_chondrocyte_physiolo1.53921053
42MP0004142_abnormal_muscle_tone1.51462774
43MP0001970_abnormal_pain_threshold1.43410560
44MP0000516_abnormal_urinary_system1.43002519
45MP0005367_renal/urinary_system_phenotyp1.43002519
46MP0002876_abnormal_thyroid_physiology1.42755089
47MP0005423_abnormal_somatic_nervous1.39445873
48MP0004858_abnormal_nervous_system1.36990345
49MP0000604_amyloidosis1.33901639
50MP0008877_abnormal_DNA_methylation1.31998713
51MP0003879_abnormal_hair_cell1.31825807
52MP0008569_lethality_at_weaning1.30950523
53MP0002118_abnormal_lipid_homeostasis1.30657286
54MP0009840_abnormal_foam_cell1.26244536
55MP0005386_behavior/neurological_phenoty1.25740410
56MP0004924_abnormal_behavior1.25740410
57MP0004043_abnormal_pH_regulation1.25466158
58MP0002653_abnormal_ependyma_morphology1.24202703
59MP0003690_abnormal_glial_cell1.22504315
60MP0001984_abnormal_olfaction1.22401494
61MP0005535_abnormal_body_temperature1.21893413
62MP0002184_abnormal_innervation1.19747637
63MP0002638_abnormal_pupillary_reflex1.19233638
64MP0001188_hyperpigmentation1.19066899
65MP0003633_abnormal_nervous_system1.18081861
66MP0001666_abnormal_nutrient_absorption1.16889690
67MP0005584_abnormal_enzyme/coenzyme_acti1.13937728
68MP0002909_abnormal_adrenal_gland1.13890282
69MP0003283_abnormal_digestive_organ1.13315487
70MP0004885_abnormal_endolymph1.11450016
71MP0002557_abnormal_social/conspecific_i1.11446111
72MP0002066_abnormal_motor_capabilities/c1.10771071
73MP0006292_abnormal_olfactory_placode1.09018477
74MP0004019_abnormal_vitamin_homeostasis1.08533737
75MP0002102_abnormal_ear_morphology1.07864681
76MP0010386_abnormal_urinary_bladder1.07495204
77MP0001299_abnormal_eye_distance/1.05699583
78MP0002229_neurodegeneration1.05614760
79MP0000955_abnormal_spinal_cord1.05580632
80MP0008872_abnormal_physiological_respon1.04748577
81MP0002752_abnormal_somatic_nervous1.03413451
82MP0004811_abnormal_neuron_physiology1.01039546
83MP0003631_nervous_system_phenotype1.00547286
84MP0003868_abnormal_feces_composition1.00020114
85MP0002152_abnormal_brain_morphology0.99419014
86MP0000566_synostosis0.99240824
87MP0001485_abnormal_pinna_reflex0.97832275
88MP0001502_abnormal_circadian_rhythm0.97349523
89MP0008874_decreased_physiological_sensi0.97164487
90MP0000013_abnormal_adipose_tissue0.96862400
91MP0002234_abnormal_pharynx_morphology0.93627350
92MP0006036_abnormal_mitochondrial_physio0.92126433
93MP0001764_abnormal_homeostasis0.91364513
94MP0005551_abnormal_eye_electrophysiolog0.89593701
95MP0000778_abnormal_nervous_system0.89413824
96MP0002882_abnormal_neuron_morphology0.88642437
97MP0000631_abnormal_neuroendocrine_gland0.87459106
98MP0000534_abnormal_ureter_morphology0.86831498
99MP0006035_abnormal_mitochondrial_morpho0.85899343
100MP0000751_myopathy0.85323329
101MP0002069_abnormal_eating/drinking_beha0.84428195
102MP0000920_abnormal_myelination0.83838622
103MP0004742_abnormal_vestibular_system0.83812936
104MP0001986_abnormal_taste_sensitivity0.83634522
105MP0006072_abnormal_retinal_apoptosis0.82242023
106MP0001529_abnormal_vocalization0.81501419
107MP0003191_abnormal_cellular_cholesterol0.80939925
108MP0003656_abnormal_erythrocyte_physiolo0.80580524
109MP0001905_abnormal_dopamine_level0.79642936
110MP0003632_abnormal_nervous_system0.79247001
111MP0004147_increased_porphyrin_level0.78816944
112MP0000609_abnormal_liver_physiology0.78372773
113MP0002078_abnormal_glucose_homeostasis0.77459481
114MP0000026_abnormal_inner_ear0.76588995
115MP0005319_abnormal_enzyme/_coenzyme0.75443034
116MP0004130_abnormal_muscle_cell0.74314196
117MP0002249_abnormal_larynx_morphology0.72862874
118MP0005645_abnormal_hypothalamus_physiol0.70264662
119MP0005253_abnormal_eye_physiology0.70033050
120MP0009697_abnormal_copulation0.69103001
121MP0000049_abnormal_middle_ear0.68433063
122MP0005195_abnormal_posterior_eye0.68280698
123MP0005636_abnormal_mineral_homeostasis0.67627350
124MP0003861_abnormal_nervous_system0.67495863
125MP0003787_abnormal_imprinting0.67089636
126MP0001765_abnormal_ion_homeostasis0.66327737
127MP0004145_abnormal_muscle_electrophysio0.65723750
128MP0001756_abnormal_urination0.65388574
129MP0002090_abnormal_vision0.64696165
130MP0004085_abnormal_heartbeat0.64632059
131MP0001270_distended_abdomen0.64624180
132MP0003183_abnormal_peptide_metabolism0.64611940
133MP0001963_abnormal_hearing_physiology0.62947807
134MP0003646_muscle_fatigue0.62820866
135MP0003123_paternal_imprinting0.61134985
136MP0002233_abnormal_nose_morphology0.60150022

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.71040346
2Myokymia (HP:0002411)4.68473339
3Abnormality of aromatic amino acid family metabolism (HP:0004338)4.66391992
4Atonic seizures (HP:0010819)4.28283374
5Polyphagia (HP:0002591)4.27904245
6Deep venous thrombosis (HP:0002625)3.97787917
7Intrahepatic cholestasis (HP:0001406)3.87509633
8Focal seizures (HP:0007359)3.82949694
9Febrile seizures (HP:0002373)3.72373776
10Limb dystonia (HP:0002451)3.64437411
11Hyperventilation (HP:0002883)3.47365853
12Absence seizures (HP:0002121)3.46016251
13Xanthomatosis (HP:0000991)3.40512817
14Epileptic encephalopathy (HP:0200134)3.35468872
15Prolonged partial thromboplastin time (HP:0003645)3.33764012
16Pheochromocytoma (HP:0002666)3.25969749
17Hypobetalipoproteinemia (HP:0003563)3.22944684
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.21131026
19Hyperlipoproteinemia (HP:0010980)3.20106676
20Generalized tonic-clonic seizures (HP:0002069)3.18002356
21Ketosis (HP:0001946)3.13161978
22Gait imbalance (HP:0002141)3.11688821
23Neuroendocrine neoplasm (HP:0100634)3.09300011
24Status epilepticus (HP:0002133)3.07183506
25Dialeptic seizures (HP:0011146)3.04642131
26Visual hallucinations (HP:0002367)3.03626234
27Progressive cerebellar ataxia (HP:0002073)2.99834739
28Action tremor (HP:0002345)2.95241417
29Hyperglycinemia (HP:0002154)2.91843373
30Gout (HP:0001997)2.80872396
31Hemiparesis (HP:0001269)2.71177058
32Medial flaring of the eyebrow (HP:0010747)2.68915214
33Hyperammonemia (HP:0001987)2.68713008
34Ketoacidosis (HP:0001993)2.68168546
35Cholecystitis (HP:0001082)2.65359975
36Abnormal gallbladder physiology (HP:0012438)2.65359975
37Complement deficiency (HP:0004431)2.57599923
38Drooling (HP:0002307)2.56640360
39Scanning speech (HP:0002168)2.55678192
40Absent speech (HP:0001344)2.52912454
41Inability to walk (HP:0002540)2.51991476
42Abnormality of glycine metabolism (HP:0010895)2.49138733
43Abnormality of serine family amino acid metabolism (HP:0010894)2.49138733
44Cerebral hypomyelination (HP:0006808)2.45588099
45Dysdiadochokinesis (HP:0002075)2.45542410
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42101968
47Impaired vibration sensation in the lower limbs (HP:0002166)2.41846637
48Conjugated hyperbilirubinemia (HP:0002908)2.40601120
49Sensorimotor neuropathy (HP:0007141)2.40246579
50Hyperglycinuria (HP:0003108)2.38318220
51Congenital primary aphakia (HP:0007707)2.38075692
52Abnormal gallbladder morphology (HP:0012437)2.37747409
53Dysmetria (HP:0001310)2.36850950
54Hypolipoproteinemia (HP:0010981)2.36612047
55Cerebral edema (HP:0002181)2.36439538
56Gaze-evoked nystagmus (HP:0000640)2.32548257
57Nephrogenic diabetes insipidus (HP:0009806)2.31265685
58Cholelithiasis (HP:0001081)2.31180371
59Epidermoid cyst (HP:0200040)2.30164857
60Excessive salivation (HP:0003781)2.28111161
61Spastic tetraplegia (HP:0002510)2.27370937
62Anxiety (HP:0000739)2.26053630
63Abnormal eating behavior (HP:0100738)2.25490347
64Abnormality of the labia minora (HP:0012880)2.24980449
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.24384060
66Lissencephaly (HP:0001339)2.21821533
67Abnormality of sulfur amino acid metabolism (HP:0004339)2.21214689
68Supranuclear gaze palsy (HP:0000605)2.20806123
69Abnormality of the lower motor neuron (HP:0002366)2.18679546
70Impaired smooth pursuit (HP:0007772)2.18315314
71Acute encephalopathy (HP:0006846)2.17904441
72Abnormal social behavior (HP:0012433)2.17728747
73Impaired social interactions (HP:0000735)2.17728747
74Aplasia/Hypoplasia of the brainstem (HP:0007362)2.17551683
75Hypoplasia of the brainstem (HP:0002365)2.17551683
76Sleep apnea (HP:0010535)2.17160889
77Retinal dysplasia (HP:0007973)2.16720902
78Esotropia (HP:0000565)2.16583962
79Amblyopia (HP:0000646)2.16481398
80Epileptiform EEG discharges (HP:0011182)2.16367394
81Neurofibrillary tangles (HP:0002185)2.15623191
82Abnormality of binocular vision (HP:0011514)2.14148588
83Diplopia (HP:0000651)2.14148588
84Abnormality of methionine metabolism (HP:0010901)2.14098873
85Spastic gait (HP:0002064)2.11682105
86Specific learning disability (HP:0001328)2.11276961
87Hypoalphalipoproteinemia (HP:0003233)2.10963712
88Dysmetric saccades (HP:0000641)2.10921506
89EEG with generalized epileptiform discharges (HP:0011198)2.09960480
90Molar tooth sign on MRI (HP:0002419)2.09036585
91Abnormality of midbrain morphology (HP:0002418)2.09036585
92Type II lissencephaly (HP:0007260)2.08951568
93Fat malabsorption (HP:0002630)2.08750088
94Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08597104
95Neonatal onset (HP:0003623)2.07493327
96Hyperbilirubinemia (HP:0002904)2.04337757
97Hypsarrhythmia (HP:0002521)2.04128623
98Joint hemorrhage (HP:0005261)2.04071420
99Focal dystonia (HP:0004373)2.03442790
100Torticollis (HP:0000473)2.02995701
101Metabolic acidosis (HP:0001942)2.02945630
102Metaphyseal dysplasia (HP:0100255)2.02741363
103Cerebral hemorrhage (HP:0001342)2.02636592
104Postural instability (HP:0002172)2.01710752
105Lethargy (HP:0001254)2.01106807
106Hypoglycemic coma (HP:0001325)2.00661867
107Broad-based gait (HP:0002136)2.00037833
108Akinesia (HP:0002304)1.98431004
109Abnormal mitochondria in muscle tissue (HP:0008316)1.98324314
110Abnormality of the common coagulation pathway (HP:0010990)1.98257231
111Intention tremor (HP:0002080)1.98003259
112Generalized myoclonic seizures (HP:0002123)1.97666980
113Craniofacial dystonia (HP:0012179)1.97308148
114Pachygyria (HP:0001302)1.96763323
115Mutism (HP:0002300)1.96701935
116Impaired vibratory sensation (HP:0002495)1.96496086
117Depression (HP:0000716)1.94872580
118Truncal ataxia (HP:0002078)1.94100772
119Failure to thrive in infancy (HP:0001531)1.92031789
120Severe muscular hypotonia (HP:0006829)1.91971585
121Athetosis (HP:0002305)1.91878470
122Hemiplegia (HP:0002301)1.91789436
123Delayed CNS myelination (HP:0002188)1.91727829
124Morphological abnormality of the pyramidal tract (HP:0002062)1.91446444
125Ankle clonus (HP:0011448)1.90934220
126Confusion (HP:0001289)1.89770812
127Abnormality of fatty-acid metabolism (HP:0004359)1.89324121
128Poor eye contact (HP:0000817)1.89133570
129Abnormality of purine metabolism (HP:0004352)1.88295141
130Poor suck (HP:0002033)1.88065916
131Acute necrotizing encephalopathy (HP:0006965)1.86040453
132Pancreatic fibrosis (HP:0100732)1.85954295
133Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85789419
134Hepatoblastoma (HP:0002884)1.84974961
135Cerebral inclusion bodies (HP:0100314)1.84868429
136Abnormality of the gallbladder (HP:0005264)1.84332558
137Amyotrophic lateral sclerosis (HP:0007354)1.84014311
138Abnormality of ocular smooth pursuit (HP:0000617)1.82828886
139Abnormality of the corticospinal tract (HP:0002492)1.82422882
140Genital tract atresia (HP:0001827)1.82378602
141Skin nodule (HP:0200036)1.82356935
142Mitral stenosis (HP:0001718)1.79250611
143Hyperthyroidism (HP:0000836)1.76120739
144Occipital encephalocele (HP:0002085)1.76088949
145Postural tremor (HP:0002174)1.76016791
146Intellectual disability, severe (HP:0010864)1.75585035
147Prolonged neonatal jaundice (HP:0006579)1.75308590
148Vaginal atresia (HP:0000148)1.74470925
149Progressive inability to walk (HP:0002505)1.74102403
150CNS hypomyelination (HP:0003429)1.73780015
151Genetic anticipation (HP:0003743)1.71409252
152Agitation (HP:0000713)1.70641358
153Muscular hypotonia of the trunk (HP:0008936)1.70499326
154Delusions (HP:0000746)1.69253958
155Congenital stationary night blindness (HP:0007642)1.68342526
156Narrow forehead (HP:0000341)1.63946398
157Poor coordination (HP:0002370)1.63196356
158Dyskinesia (HP:0100660)1.62663503
159Urinary bladder sphincter dysfunction (HP:0002839)1.62565501
160Autoamputation (HP:0001218)1.60377914
161Clonus (HP:0002169)1.60347968

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK15.37116021
2NTRK33.98726007
3CASK3.07632223
4MAP3K43.02639367
5EPHA42.97211788
6MAP3K92.85189777
7MAP2K42.66543611
8DAPK22.63030229
9MAP2K72.52866778
10MINK12.38347946
11ACVR1B2.24139462
12OXSR12.18290458
13MAP3K122.00284600
14BMPR1B1.95780230
15CDK191.89660248
16NTRK11.89431489
17FRK1.88682237
18PAK61.88668236
19ARAF1.72478192
20KSR21.69930451
21BCKDK1.59839719
22MARK11.59564675
23MAP4K21.51182185
24SGK2231.51140746
25SGK4941.51140746
26NTRK21.45795548
27PRKCG1.40861558
28PRPF4B1.40603160
29GRK51.38601151
30STK391.35103395
31WNK41.34616283
32DAPK11.32916241
33PINK11.32209366
34SGK21.32107384
35CAMKK11.27037034
36ERBB41.24667793
37CAMKK21.20352743
38INSRR1.19926402
39CDK51.19048755
40DYRK21.17184119
41STK381.17159871
42AKT31.13149976
43PHKG11.12904844
44PHKG21.12904844
45WNK11.12777124
46LMTK21.12744555
47PLK21.09486632
48MAP3K21.08133658
49DYRK1A1.05672598
50GRK11.05403914
51LIMK11.04688306
52SGK31.04238586
53MAP3K131.02765214
54TNIK1.02696610
55CAMK2A1.00712039
56PDK40.97316345
57PDK30.97316345
58CAMK2G0.96767998
59WNK30.94931408
60RIPK40.93468264
61KSR10.92940373
62SIK30.92004618
63TLK10.91411468
64MUSK0.90255459
65CSNK1G30.86912912
66MAPK130.85238995
67TRIM280.82355557
68CAMK2B0.80832223
69PDPK10.79752162
70PRKCH0.79255207
71SIK10.78009565
72RET0.75814579
73TESK10.73396009
74UHMK10.73387521
75CSNK1A1L0.73172594
76PAK30.72879180
77BRAF0.71572694
78MAP3K110.71115589
79PIM20.70976312
80CAMK2D0.69863901
81TNK20.69800250
82PKN10.69387565
83PRKD30.68617514
84BCR0.68596413
85SIK20.67213749
86CSNK1G20.66458912
87PDK10.65969777
88PRKCE0.64911429
89CDK180.64757271
90CDK150.61706116
91CDK140.60830230
92MAP3K70.60473688
93STK110.59392735
94PNCK0.59137712
95FES0.58942531
96MAP3K10.58496259
97PRKCZ0.57827770
98LATS20.57456159
99FER0.57088927
100MAP2K10.56743470
101FGFR20.56678122
102NEK10.56045288
103EPHB20.55959943
104ERBB30.55294041
105ADRBK20.55173569
106PRKD20.53210717
107SGK10.53144965
108CSNK1G10.53120869
109CAMK10.52773386
110PTK2B0.52161266
111NME10.52002184
112DYRK1B0.51124488
113GRK70.50995534
114CDK11A0.49179860
115MARK20.48939896
116FGFR40.48174022
117MAPK120.47066350
118RPS6KA30.46631286
119PRKACG0.46587229
120PRKACA0.46132519
121ADRBK10.45162372
122EPHA30.43377262
123RAF10.42101531
124PRKAA10.41431116
125PRKCA0.40881684
126BMPR20.40830411
127EPHA20.39794920
128PIK3CG0.38173315
129ERBB20.38142675
130CSNK1A10.37813283
131PRKCI0.36526394
132CDK30.36172408
133CAMK40.32428456
134NUAK10.32295378
135PRKG10.32097945
136TESK20.31779929

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.61543483
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.93773502
3Nitrogen metabolism_Homo sapiens_hsa009102.79223202
4Arginine biosynthesis_Homo sapiens_hsa002202.44643892
5Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31690341
6Synaptic vesicle cycle_Homo sapiens_hsa047212.27741427
7Nicotine addiction_Homo sapiens_hsa050332.21773868
8Butanoate metabolism_Homo sapiens_hsa006502.21622476
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.07522404
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.97874170
11Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.92719580
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.90550712
13Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.85039616
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.78909714
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.70521056
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68220628
17Tryptophan metabolism_Homo sapiens_hsa003801.68078087
18Propanoate metabolism_Homo sapiens_hsa006401.63270418
19GABAergic synapse_Homo sapiens_hsa047271.62043181
20Fatty acid degradation_Homo sapiens_hsa000711.61959409
21Pyruvate metabolism_Homo sapiens_hsa006201.60219354
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.56495888
23Bile secretion_Homo sapiens_hsa049761.52075838
24Collecting duct acid secretion_Homo sapiens_hsa049661.51840182
25Phototransduction_Homo sapiens_hsa047441.47420202
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.43288080
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40300625
28Fatty acid metabolism_Homo sapiens_hsa012121.39458456
29Complement and coagulation cascades_Homo sapiens_hsa046101.37632355
30Peroxisome_Homo sapiens_hsa041461.37053937
31Phenylalanine metabolism_Homo sapiens_hsa003601.21935812
32Fatty acid elongation_Homo sapiens_hsa000621.21492744
33Glutamatergic synapse_Homo sapiens_hsa047241.20239022
34Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.17439593
35Circadian entrainment_Homo sapiens_hsa047131.16935237
36Morphine addiction_Homo sapiens_hsa050321.13674527
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13329298
38beta-Alanine metabolism_Homo sapiens_hsa004101.12430711
39PPAR signaling pathway_Homo sapiens_hsa033201.11442638
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10920761
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.10891576
42Sulfur metabolism_Homo sapiens_hsa009201.09902773
43Histidine metabolism_Homo sapiens_hsa003401.08777739
44Insulin secretion_Homo sapiens_hsa049111.08468034
45Taste transduction_Homo sapiens_hsa047421.06659378
46Circadian rhythm_Homo sapiens_hsa047101.05974717
47Linoleic acid metabolism_Homo sapiens_hsa005911.04117514
48Axon guidance_Homo sapiens_hsa043601.03902073
49Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03147295
50Steroid hormone biosynthesis_Homo sapiens_hsa001401.02553639
51Long-term potentiation_Homo sapiens_hsa047201.01452493
52Amphetamine addiction_Homo sapiens_hsa050311.01019953
53Olfactory transduction_Homo sapiens_hsa047401.00097206
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.99758405
55Carbon metabolism_Homo sapiens_hsa012000.99452899
56Tyrosine metabolism_Homo sapiens_hsa003500.97519372
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.97495081
58Oxidative phosphorylation_Homo sapiens_hsa001900.95928515
59Salivary secretion_Homo sapiens_hsa049700.94511153
60Chemical carcinogenesis_Homo sapiens_hsa052040.92483424
61Sphingolipid metabolism_Homo sapiens_hsa006000.92394156
62Biosynthesis of amino acids_Homo sapiens_hsa012300.87603395
63Dopaminergic synapse_Homo sapiens_hsa047280.84851791
64Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84677754
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.80868695
66Pancreatic secretion_Homo sapiens_hsa049720.75916761
67ABC transporters_Homo sapiens_hsa020100.74567223
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73735061
69Retinol metabolism_Homo sapiens_hsa008300.73552558
70Steroid biosynthesis_Homo sapiens_hsa001000.72718489
71Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71930963
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71295492
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70523418
74Gastric acid secretion_Homo sapiens_hsa049710.70471158
75Starch and sucrose metabolism_Homo sapiens_hsa005000.70243473
76Vitamin B6 metabolism_Homo sapiens_hsa007500.70019500
77Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69708943
78Vibrio cholerae infection_Homo sapiens_hsa051100.69617161
79Sulfur relay system_Homo sapiens_hsa041220.65133826
80Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.64133237
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64072594
82Serotonergic synapse_Homo sapiens_hsa047260.63914141
83Arginine and proline metabolism_Homo sapiens_hsa003300.63088955
84Ether lipid metabolism_Homo sapiens_hsa005650.62827609
85Drug metabolism - other enzymes_Homo sapiens_hsa009830.62723322
86Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62441220
87Long-term depression_Homo sapiens_hsa047300.62263743
88Cholinergic synapse_Homo sapiens_hsa047250.60266047
89Calcium signaling pathway_Homo sapiens_hsa040200.60249082
90Cardiac muscle contraction_Homo sapiens_hsa042600.59550082
91Mineral absorption_Homo sapiens_hsa049780.59464415
92Gap junction_Homo sapiens_hsa045400.59283615
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.58895160
94Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58571755
95Alzheimers disease_Homo sapiens_hsa050100.57834377
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.57420057
97Ovarian steroidogenesis_Homo sapiens_hsa049130.56542616
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55907203
99Cocaine addiction_Homo sapiens_hsa050300.55630848
100Parkinsons disease_Homo sapiens_hsa050120.54773543
101Glycerolipid metabolism_Homo sapiens_hsa005610.53413344
102Renin secretion_Homo sapiens_hsa049240.53141940
103Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51400077
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50656731
105Fatty acid biosynthesis_Homo sapiens_hsa000610.49387645
106Type II diabetes mellitus_Homo sapiens_hsa049300.49252194
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48416724
108Folate biosynthesis_Homo sapiens_hsa007900.47881113
109AMPK signaling pathway_Homo sapiens_hsa041520.47597335
110Regulation of autophagy_Homo sapiens_hsa041400.46860002
111Huntingtons disease_Homo sapiens_hsa050160.46660094
112Glucagon signaling pathway_Homo sapiens_hsa049220.46201211
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45362115
114Melanogenesis_Homo sapiens_hsa049160.45272980
115Caffeine metabolism_Homo sapiens_hsa002320.45006819
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44630600
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.44455635
118Staphylococcus aureus infection_Homo sapiens_hsa051500.44283844
119Oxytocin signaling pathway_Homo sapiens_hsa049210.40435454
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39788125
121Fat digestion and absorption_Homo sapiens_hsa049750.39493496
122cAMP signaling pathway_Homo sapiens_hsa040240.36414987
123Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35693149
124Fructose and mannose metabolism_Homo sapiens_hsa000510.35221025
125Thyroid hormone synthesis_Homo sapiens_hsa049180.34855199

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