TMEM249

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of action potential (GO:0045760)5.47270242
2positive regulation of amino acid transport (GO:0051957)5.03914987
3histone H4-K12 acetylation (GO:0043983)4.43236231
4positive regulation of vesicle fusion (GO:0031340)4.20799206
5peptidyl-arginine N-methylation (GO:0035246)4.01627930
6peptidyl-arginine methylation (GO:0018216)4.01627930
7histone H2A acetylation (GO:0043968)4.01331859
8epithelial cilium movement (GO:0003351)3.90834767
9tongue development (GO:0043586)3.85802439
10regulation of feeding behavior (GO:0060259)3.83699888
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.81659580
12transmission of nerve impulse (GO:0019226)3.79362493
13auditory behavior (GO:0031223)3.70697327
14regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.66265629
15epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.53866773
16motile cilium assembly (GO:0044458)3.52290392
17estrogen biosynthetic process (GO:0006703)3.51216244
18negative regulation of heart rate (GO:0010459)3.40407081
19regulation of cilium movement (GO:0003352)3.36804793
20short-term memory (GO:0007614)3.35765182
21tachykinin receptor signaling pathway (GO:0007217)3.35505804
22negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.32953401
23DNA methylation involved in gamete generation (GO:0043046)3.31537754
24pyrimidine nucleobase catabolic process (GO:0006208)3.29715541
25protein polyglutamylation (GO:0018095)3.28884130
26regulation of glucokinase activity (GO:0033131)3.24845266
27regulation of hexokinase activity (GO:1903299)3.24845266
28head development (GO:0060322)3.23398412
29protein neddylation (GO:0045116)3.22834953
30dopaminergic neuron differentiation (GO:0071542)3.16019018
31substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.11142986
32substrate-independent telencephalic tangential migration (GO:0021826)3.11142986
33regulation of action potential (GO:0098900)3.09097165
34adult walking behavior (GO:0007628)3.04873712
35imidazole-containing compound metabolic process (GO:0052803)3.03987542
36cell migration in hindbrain (GO:0021535)3.02406595
37detection of light stimulus involved in visual perception (GO:0050908)3.02211676
38detection of light stimulus involved in sensory perception (GO:0050962)3.02211676
39positive regulation of protein targeting to membrane (GO:0090314)2.96011404
40mechanosensory behavior (GO:0007638)2.94963540
41sensory perception of taste (GO:0050909)2.94752641
42negative regulation of amino acid transport (GO:0051956)2.93065760
43acrosome reaction (GO:0007340)2.93025604
44positive regulation of protein homodimerization activity (GO:0090073)2.90224003
45regulation of synapse structural plasticity (GO:0051823)2.89708951
46white fat cell differentiation (GO:0050872)2.89524305
47axoneme assembly (GO:0035082)2.89423276
48negative regulation of cytosolic calcium ion concentration (GO:0051481)2.87603319
49piRNA metabolic process (GO:0034587)2.83267213
50establishment of mitochondrion localization (GO:0051654)2.83122704
51neurofilament cytoskeleton organization (GO:0060052)2.81815572
52response to auditory stimulus (GO:0010996)2.81494259
53C4-dicarboxylate transport (GO:0015740)2.81242268
54behavioral response to nicotine (GO:0035095)2.79705812
55cerebellar granule cell differentiation (GO:0021707)2.79497140
56neuron recognition (GO:0008038)2.75877997
57neuronal action potential (GO:0019228)2.75745532
58parturition (GO:0007567)2.74439062
59peptidyl-arginine omega-N-methylation (GO:0035247)2.73424282
60peristalsis (GO:0030432)2.73344146
61negative regulation of telomere maintenance (GO:0032205)2.73070438
62axonemal dynein complex assembly (GO:0070286)2.72457483
63adaptation of signaling pathway (GO:0023058)2.71499506
64positive regulation of synapse assembly (GO:0051965)2.71497779
65cilium movement (GO:0003341)2.69088654
66ionotropic glutamate receptor signaling pathway (GO:0035235)2.67685335
67negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.67573785
68negative regulation of translation, ncRNA-mediated (GO:0040033)2.67573785
69regulation of translation, ncRNA-mediated (GO:0045974)2.67573785
70positive regulation of mitochondrial fission (GO:0090141)2.67274003
71positive regulation of amine transport (GO:0051954)2.66368074
72prepulse inhibition (GO:0060134)2.66098490
73resolution of meiotic recombination intermediates (GO:0000712)2.65236971
74response to misfolded protein (GO:0051788)2.64935975
75cell differentiation in hindbrain (GO:0021533)2.63404750
76cerebellar Purkinje cell differentiation (GO:0021702)2.61952856
77centriole assembly (GO:0098534)2.59526288
78histone arginine methylation (GO:0034969)2.58554846
79positive regulation of synapse maturation (GO:0090129)2.58478478
80gamma-aminobutyric acid transport (GO:0015812)2.57358666
81nucleobase catabolic process (GO:0046113)2.57338974
82negative regulation of appetite (GO:0032099)2.56790363
83negative regulation of response to food (GO:0032096)2.56790363
84regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.55639373
85positive regulation of gastrulation (GO:2000543)2.55221362
86establishment of protein localization to mitochondrial membrane (GO:0090151)2.51144283
87glycerophospholipid catabolic process (GO:0046475)2.50478490
88membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.50199187
89neuronal action potential propagation (GO:0019227)2.50098945
90neuronal ion channel clustering (GO:0045161)2.49438877
91synaptic transmission, glutamatergic (GO:0035249)2.46637334
92regulation of calcium ion-dependent exocytosis (GO:0017158)2.46613369
93detection of calcium ion (GO:0005513)2.46007170
94regulation of vesicle fusion (GO:0031338)2.45767778
95cerebral cortex radially oriented cell migration (GO:0021799)2.45698800
96startle response (GO:0001964)2.44715740
97regulation of microtubule-based movement (GO:0060632)2.43904263
98sperm motility (GO:0030317)2.43382972
99behavioral response to cocaine (GO:0048148)2.42631692
100protein K6-linked ubiquitination (GO:0085020)2.41351585

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human8.60455243
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.27415830
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.98359685
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.66565949
5VDR_22108803_ChIP-Seq_LS180_Human2.40872472
6REST_21632747_ChIP-Seq_MESCs_Mouse2.34742980
7ERG_21242973_ChIP-ChIP_JURKAT_Human2.26913984
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.26127722
9CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25759465
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.18453538
11CBX2_27304074_Chip-Seq_ESCs_Mouse2.10859581
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.03619020
13REST_18959480_ChIP-ChIP_MESCs_Mouse1.97097714
14JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93933129
15SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93378187
16GBX2_23144817_ChIP-Seq_PC3_Human1.91913184
17BMI1_23680149_ChIP-Seq_NPCS_Mouse1.87613555
18PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.86524558
19CTCF_27219007_Chip-Seq_Bcells_Human1.81309414
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.80968847
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.71096676
22JARID2_20075857_ChIP-Seq_MESCs_Mouse1.70697224
23MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67376101
24CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65537665
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.60924489
26RNF2_18974828_ChIP-Seq_MESCs_Mouse1.59141905
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.59141905
28DROSHA_22980978_ChIP-Seq_HELA_Human1.56561347
29ZNF274_21170338_ChIP-Seq_K562_Hela1.55366591
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.54447742
31ZNF263_19887448_ChIP-Seq_K562_Human1.52101338
32RNF2_27304074_Chip-Seq_NSC_Mouse1.50720175
33RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.50335824
34CTBP1_25329375_ChIP-Seq_LNCAP_Human1.47036824
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46816239
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41285778
37RUNX1_26923725_Chip-Seq_HPCs_Mouse1.40679625
38SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40372890
39SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.40053516
40SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.38151249
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.33680541
42IGF1R_20145208_ChIP-Seq_DFB_Human1.32327224
43RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.26356206
44GATA1_26923725_Chip-Seq_HPCs_Mouse1.26214423
45MYC_18940864_ChIP-ChIP_HL60_Human1.26173472
46TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23911333
47POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22717951
48TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22717951
49HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.18107880
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.16949986
51WDR5_24793694_ChIP-Seq_LNCAP_Human1.16379424
52FUS_26573619_Chip-Seq_HEK293_Human1.16110889
53ER_23166858_ChIP-Seq_MCF-7_Human1.15163595
54EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.14689070
55P68_20966046_ChIP-Seq_HELA_Human1.14375103
56MTF2_20144788_ChIP-Seq_MESCs_Mouse1.11602347
57EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11435822
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10409703
59MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.08300351
60ELF1_20517297_ChIP-Seq_JURKAT_Human1.07765167
61NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.07737313
62ERA_21632823_ChIP-Seq_H3396_Human1.07562957
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06958482
64EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04898549
65PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04300323
66BCL6_27268052_Chip-Seq_Bcells_Human1.04289128
67PHF8_20622854_ChIP-Seq_HELA_Human1.03481293
68AR_25329375_ChIP-Seq_VCAP_Human1.02720813
69PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.01805644
70MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.00540380
71ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.00318050
72ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99675314
73E2F1_20622854_ChIP-Seq_HELA_Human0.97878542
74JUN_21703547_ChIP-Seq_K562_Human0.97826476
75IKZF1_21737484_ChIP-ChIP_HCT116_Human0.97478958
76MYC_19829295_ChIP-Seq_ESCs_Human0.97124931
77YY1_22570637_ChIP-Seq_MALME-3M_Human0.96851002
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.96785289
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96424336
80TET1_21451524_ChIP-Seq_MESCs_Mouse0.95666310
81RARB_27405468_Chip-Seq_BRAIN_Mouse0.95433416
82EWS_26573619_Chip-Seq_HEK293_Human0.94982401
83RAC3_21632823_ChIP-Seq_H3396_Human0.92789781
84CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.92583604
85TOP2B_26459242_ChIP-Seq_MCF-7_Human0.91396958
86OCT4_20526341_ChIP-Seq_ESCs_Human0.89768195
87TAF2_19829295_ChIP-Seq_ESCs_Human0.89762422
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.89724692
89ELK4_26923725_Chip-Seq_MESODERM_Mouse0.89060380
90TP53_22573176_ChIP-Seq_HFKS_Human0.87996379
91FOXP1_21924763_ChIP-Seq_HESCs_Human0.87507985
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.86764990
93TP63_19390658_ChIP-ChIP_HaCaT_Human0.86016675
94SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85408296
95P300_19829295_ChIP-Seq_ESCs_Human0.83722554
96XRN2_22483619_ChIP-Seq_HELA_Human0.83401009
97CBP_20019798_ChIP-Seq_JUKART_Human0.82467874
98IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82467874
99RXR_22108803_ChIP-Seq_LS180_Human0.82307517
100GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.82194952

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.72211698
2MP0005423_abnormal_somatic_nervous2.83940396
3MP0002160_abnormal_reproductive_system2.66283962
4MP0001905_abnormal_dopamine_level2.54907987
5MP0003787_abnormal_imprinting2.54019639
6MP0001968_abnormal_touch/_nociception2.39934550
7MP0001485_abnormal_pinna_reflex2.36789871
8MP0008789_abnormal_olfactory_epithelium2.27294316
9MP0003878_abnormal_ear_physiology2.25664369
10MP0005377_hearing/vestibular/ear_phenot2.25664369
11MP0004147_increased_porphyrin_level2.24913884
12MP0004885_abnormal_endolymph2.22874753
13MP0001486_abnormal_startle_reflex2.21275183
14MP0001529_abnormal_vocalization2.14061991
15MP0002184_abnormal_innervation2.12891330
16MP0002272_abnormal_nervous_system2.10084835
17MP0006276_abnormal_autonomic_nervous2.09259537
18MP0002102_abnormal_ear_morphology1.93400764
19MP0006292_abnormal_olfactory_placode1.91601380
20MP0003635_abnormal_synaptic_transmissio1.89793232
21MP0009046_muscle_twitch1.82626333
22MP0000427_abnormal_hair_cycle1.78394247
23MP0002735_abnormal_chemical_nociception1.77459809
24MP0009745_abnormal_behavioral_response1.76001138
25MP0003136_yellow_coat_color1.74871093
26MP0002736_abnormal_nociception_after1.71465431
27MP0002572_abnormal_emotion/affect_behav1.71051592
28MP0005551_abnormal_eye_electrophysiolog1.67777214
29MP0000778_abnormal_nervous_system1.67356380
30MP0005379_endocrine/exocrine_gland_phen1.66634794
31MP0005394_taste/olfaction_phenotype1.62512024
32MP0005499_abnormal_olfactory_system1.62512024
33MP0002234_abnormal_pharynx_morphology1.61935419
34MP0002163_abnormal_gland_morphology1.61896605
35MP0000955_abnormal_spinal_cord1.59424004
36MP0001188_hyperpigmentation1.59320571
37MP0003879_abnormal_hair_cell1.54300817
38MP0000566_synostosis1.54149157
39MP0001986_abnormal_taste_sensitivity1.53199642
40MP0004859_abnormal_synaptic_plasticity1.52270640
41MP0002063_abnormal_learning/memory/cond1.50488145
42MP0002734_abnormal_mechanical_nocicepti1.47265105
43MP0005389_reproductive_system_phenotype1.46388412
44MP0002067_abnormal_sensory_capabilities1.45777483
45MP0002064_seizures1.35387825
46MP0004270_analgesia1.30738736
47MP0002210_abnormal_sex_determination1.28898635
48MP0000026_abnormal_inner_ear1.27929474
49MP0001970_abnormal_pain_threshold1.27825510
50MP0000049_abnormal_middle_ear1.27179178
51MP0004133_heterotaxia1.25848360
52MP0002653_abnormal_ependyma_morphology1.25660143
53MP0005409_darkened_coat_color1.21584870
54MP0002557_abnormal_social/conspecific_i1.20291122
55MP0001849_ear_inflammation1.18416130
56MP0003938_abnormal_ear_development1.18191247
57MP0002733_abnormal_thermal_nociception1.17603902
58MP0003693_abnormal_embryo_hatching1.16786760
59MP0002882_abnormal_neuron_morphology1.14979573
60MP0004019_abnormal_vitamin_homeostasis1.14973066
61MP0003698_abnormal_male_reproductive1.12346075
62MP0000678_abnormal_parathyroid_gland1.10756736
63MP0005410_abnormal_fertilization1.09930987
64MP0009379_abnormal_foot_pigmentation1.09674572
65MP0002752_abnormal_somatic_nervous1.09516003
66MP0003303_peritoneal_inflammation1.08495448
67MP0001963_abnormal_hearing_physiology1.07016583
68MP0002152_abnormal_brain_morphology1.04736324
69MP0002822_catalepsy1.04599130
70MP0002233_abnormal_nose_morphology1.03330356
71MP0008875_abnormal_xenobiotic_pharmacok1.03146957
72MP0003121_genomic_imprinting1.03096568
73MP0003861_abnormal_nervous_system1.02886690
74MP0003123_paternal_imprinting0.94669077
75MP0000631_abnormal_neuroendocrine_gland0.94545891
76MP0004742_abnormal_vestibular_system0.94491226
77MP0004142_abnormal_muscle_tone0.93177409
78MP0003122_maternal_imprinting0.92062995
79MP0008058_abnormal_DNA_repair0.90187118
80MP0003755_abnormal_palate_morphology0.88680289
81MP0002066_abnormal_motor_capabilities/c0.87066002
82MP0004924_abnormal_behavior0.86330981
83MP0005386_behavior/neurological_phenoty0.86330981
84MP0001929_abnormal_gametogenesis0.85918330
85MP0002229_neurodegeneration0.84929580
86MP0001984_abnormal_olfaction0.84817156
87MP0002909_abnormal_adrenal_gland0.83748769
88MP0001348_abnormal_lacrimal_gland0.83495673
89MP0001145_abnormal_male_reproductive0.80634410
90MP0005195_abnormal_posterior_eye0.79528183
91MP0005645_abnormal_hypothalamus_physiol0.79521474
92MP0000613_abnormal_salivary_gland0.78699260
93MP0000653_abnormal_sex_gland0.78662179
94MP0001502_abnormal_circadian_rhythm0.78268328
95MP0008877_abnormal_DNA_methylation0.77058332
96MP0004811_abnormal_neuron_physiology0.76623164
97MP0003942_abnormal_urinary_system0.75906191
98MP0002938_white_spotting0.73548222
99MP0002693_abnormal_pancreas_physiology0.73220836
100MP0005220_abnormal_exocrine_pancreas0.73030901

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.24476442
2Nephronophthisis (HP:0000090)3.95291793
3Annular pancreas (HP:0001734)3.42207276
4Amblyopia (HP:0000646)3.22504414
5Medial flaring of the eyebrow (HP:0010747)3.19054812
6Increased hepatocellular lipid droplets (HP:0006565)3.18884812
7Gait imbalance (HP:0002141)3.11372497
8Progressive cerebellar ataxia (HP:0002073)3.08832021
9Abnormality of the renal medulla (HP:0100957)3.07947444
10Congenital stationary night blindness (HP:0007642)2.96445037
11Tubular atrophy (HP:0000092)2.96138458
12Congenital primary aphakia (HP:0007707)2.90367716
13Pancreatic fibrosis (HP:0100732)2.89770883
14Lipid accumulation in hepatocytes (HP:0006561)2.87839929
15Increased intramyocellular lipid droplets (HP:0012240)2.83398234
16Pancreatic cysts (HP:0001737)2.79270604
17Rib fusion (HP:0000902)2.77915399
18Abnormal rod and cone electroretinograms (HP:0008323)2.76722029
19Neonatal hypoglycemia (HP:0001998)2.69640921
20True hermaphroditism (HP:0010459)2.68770691
21Nephrogenic diabetes insipidus (HP:0009806)2.60299087
22Abnormal mitochondria in muscle tissue (HP:0008316)2.52753980
23Delayed epiphyseal ossification (HP:0002663)2.51149756
24Chorioretinal atrophy (HP:0000533)2.50283002
25Occipital encephalocele (HP:0002085)2.48063240
26Renal Fanconi syndrome (HP:0001994)2.47939854
27Acute necrotizing encephalopathy (HP:0006965)2.40838131
28Vaginal atresia (HP:0000148)2.36884184
29Severe visual impairment (HP:0001141)2.34586199
30Proximal tubulopathy (HP:0000114)2.32989535
31Increased muscle lipid content (HP:0009058)2.26612222
32Enlarged epiphyses (HP:0010580)2.25248376
33Fetal akinesia sequence (HP:0001989)2.25090010
34Type 2 muscle fiber atrophy (HP:0003554)2.24917983
35Absent/shortened dynein arms (HP:0200106)2.21951760
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.21951760
37Left ventricular hypertrophy (HP:0001712)2.21831226
38Mitochondrial inheritance (HP:0001427)2.20760711
39Genital tract atresia (HP:0001827)2.20463190
40Agitation (HP:0000713)2.20034012
41Asymmetric septal hypertrophy (HP:0001670)2.19977014
42Tubulointerstitial abnormality (HP:0001969)2.16410405
43Tubulointerstitial fibrosis (HP:0005576)2.16076587
44Acute lymphatic leukemia (HP:0006721)2.15323500
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.14364964
46Abnormal respiratory motile cilium physiology (HP:0012261)2.10053902
47Cystic liver disease (HP:0006706)2.09865686
48Glycosuria (HP:0003076)2.08402831
49Abnormality of urine glucose concentration (HP:0011016)2.08402831
50Pendular nystagmus (HP:0012043)2.07997040
51Drooling (HP:0002307)2.07934911
52Abnormal respiratory motile cilium morphology (HP:0005938)2.06570028
53Abnormal respiratory epithelium morphology (HP:0012253)2.06570028
54Abolished electroretinogram (ERG) (HP:0000550)2.06283841
55Limb dystonia (HP:0002451)2.04457611
56Muscle fiber atrophy (HP:0100295)2.03624692
57Abnormality of midbrain morphology (HP:0002418)2.03020245
58Molar tooth sign on MRI (HP:0002419)2.03020245
59Poor coordination (HP:0002370)2.02981537
60Abnormality of the renal cortex (HP:0011035)2.02821369
61Hyperventilation (HP:0002883)2.02485848
62Bony spicule pigmentary retinopathy (HP:0007737)2.01471023
63Abnormal urine phosphate concentration (HP:0012599)2.00704237
64Acute encephalopathy (HP:0006846)1.99110933
65Neoplasm of the adrenal cortex (HP:0100641)1.98909121
66Retinitis pigmentosa (HP:0000510)1.97389344
67Abnormal ciliary motility (HP:0012262)1.96296923
68Joint stiffness (HP:0001387)1.95899857
69Focal motor seizures (HP:0011153)1.90724408
70Popliteal pterygium (HP:0009756)1.90714258
71Hyperphosphaturia (HP:0003109)1.88776706
72Sclerocornea (HP:0000647)1.88514766
73Increased CSF lactate (HP:0002490)1.87757801
74Abnormality of macular pigmentation (HP:0008002)1.87086114
75Visual hallucinations (HP:0002367)1.86610512
76Tubulointerstitial nephritis (HP:0001970)1.84278781
77Abnormality of renal resorption (HP:0011038)1.83097399
78Adrenal hypoplasia (HP:0000835)1.82231819
79Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.80830061
80Decreased activity of mitochondrial respiratory chain (HP:0008972)1.80830061
81Absent thumb (HP:0009777)1.80364505
82Thin bony cortex (HP:0002753)1.79436930
83Excessive salivation (HP:0003781)1.79298838
84Hepatoblastoma (HP:0002884)1.78496728
85Generalized aminoaciduria (HP:0002909)1.78448108
86Abnormal eating behavior (HP:0100738)1.77044620
87Specific learning disability (HP:0001328)1.76210360
88Progressive macrocephaly (HP:0004481)1.74227114
89Failure to thrive in infancy (HP:0001531)1.73930709
90Abnormality of DNA repair (HP:0003254)1.72912190
91Attenuation of retinal blood vessels (HP:0007843)1.72821912
92Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.70722075
93Abnormality of alanine metabolism (HP:0010916)1.70722075
94Hyperalaninemia (HP:0003348)1.70722075
95Inability to walk (HP:0002540)1.70510483
96Lower limb asymmetry (HP:0100559)1.70441905
97Abnormal biliary tract physiology (HP:0012439)1.70065225
98Bile duct proliferation (HP:0001408)1.70065225
99Congenital hepatic fibrosis (HP:0002612)1.69545500
100Abnormal drinking behavior (HP:0030082)1.68768689

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK24.74981064
2PNCK4.08672634
3WEE13.61803449
4MARK12.87373609
5TRIM282.62427006
6BRSK22.55429612
7LATS12.54755598
8NUAK12.40576404
9VRK22.29814071
10PINK12.21038853
11CDK192.18928547
12NEK12.18739708
13MINK12.11011644
14MAP3K122.06947359
15NTRK31.98425659
16CASK1.96049915
17BCR1.69966923
18MUSK1.68776708
19MAP2K41.59027382
20TAF11.53840579
21SIK21.43456665
22BRSK11.35925784
23PIM21.34841061
24DYRK31.33838610
25MAP3K41.31881925
26UHMK11.30865877
27NTRK21.29428041
28FRK1.27321050
29MAPK151.23024244
30RPS6KA41.22527873
31DYRK21.21016656
32NME11.20514039
33TLK11.20394186
34CSNK1G31.16782813
35ADRBK21.14687761
36EIF2AK11.14672045
37EPHA21.13127941
38MAP2K61.11730368
39CSNK1G21.04920210
40CDK31.02004077
41MAP2K30.97896612
42AURKA0.97851620
43CSNK1A1L0.97354076
44TYRO30.96964543
45MET0.92866959
46EPHA40.92164103
47PRKCG0.84351141
48DYRK1A0.84089822
49TSSK60.83072430
50WNK40.82069544
51DYRK1B0.81529034
52CSNK1G10.76470068
53PRKCI0.74775390
54TNIK0.74362009
55CCNB10.72591213
56MAPK40.71334927
57PRKD30.69432409
58CAMK1G0.68113300
59MAP3K110.67328909
60ARAF0.66460790
61MAP2K20.66029634
62RPS6KA20.64272280
63CAMK1D0.63962647
64TXK0.63452636
65INSRR0.60973065
66MAP3K90.60270880
67PRKD20.60169667
68BMPR1B0.59538899
69NTRK10.58582701
70CSNK1E0.57949872
71GRK10.56770356
72BCKDK0.55436107
73MAP3K60.53881472
74MAPK80.52336645
75PAK30.51943667
76CHEK20.49867209
77VRK10.47770538
78CDK50.47398209
79MAPK130.45954636
80CSNK1A10.43954929
81WNK30.43890027
82CAMK10.43603841
83EPHB20.43493135
84BUB10.41421515
85LIMK10.40209662
86PTK2B0.39596146
87BMX0.39433706
88ERBB40.37967047
89PRKG10.37576725
90PRKCE0.36535411
91ABL20.36149039
92STK110.34712105
93PRKACA0.33175416
94STK390.33016522
95PRKDC0.31672207
96TAOK10.30734756
97PRKCH0.30727122
98CAMK2G0.28751927
99BTK0.27687055
100OXSR10.27420964

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001303.40339567
2Nicotine addiction_Homo sapiens_hsa050333.13272202
3Cardiac muscle contraction_Homo sapiens_hsa042602.60524952
4Phototransduction_Homo sapiens_hsa047442.49189665
5GABAergic synapse_Homo sapiens_hsa047272.30309819
6Glutamatergic synapse_Homo sapiens_hsa047242.19971420
7RNA polymerase_Homo sapiens_hsa030202.04039770
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.94650770
9Parkinsons disease_Homo sapiens_hsa050121.86921141
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.78343736
11Insulin secretion_Homo sapiens_hsa049111.76530524
12Morphine addiction_Homo sapiens_hsa050321.67469798
13Oxidative phosphorylation_Homo sapiens_hsa001901.66738166
14Basal transcription factors_Homo sapiens_hsa030221.65067285
15Axon guidance_Homo sapiens_hsa043601.64924831
16Homologous recombination_Homo sapiens_hsa034401.64511795
17Dopaminergic synapse_Homo sapiens_hsa047281.61223943
18Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.60195921
19Sulfur relay system_Homo sapiens_hsa041221.58959942
20Selenocompound metabolism_Homo sapiens_hsa004501.54313154
21Asthma_Homo sapiens_hsa053101.50816089
22Steroid biosynthesis_Homo sapiens_hsa001001.50426158
23Circadian entrainment_Homo sapiens_hsa047131.49746928
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.47615346
25Taste transduction_Homo sapiens_hsa047421.44946705
26Ribosome_Homo sapiens_hsa030101.43529086
27Cocaine addiction_Homo sapiens_hsa050301.41519684
28Fanconi anemia pathway_Homo sapiens_hsa034601.39219044
29Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.28900565
30Amphetamine addiction_Homo sapiens_hsa050311.28817695
31Alzheimers disease_Homo sapiens_hsa050101.25579899
32Maturity onset diabetes of the young_Homo sapiens_hsa049501.25530553
33Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25015570
34Synaptic vesicle cycle_Homo sapiens_hsa047211.24765580
35Hedgehog signaling pathway_Homo sapiens_hsa043401.24435438
36Phenylalanine metabolism_Homo sapiens_hsa003601.21117724
37Huntingtons disease_Homo sapiens_hsa050161.19843851
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18019863
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.15962438
40Serotonergic synapse_Homo sapiens_hsa047261.15709041
41Calcium signaling pathway_Homo sapiens_hsa040201.14953726
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12056088
43Salivary secretion_Homo sapiens_hsa049701.08793146
44Pentose and glucuronate interconversions_Homo sapiens_hsa000401.06604736
45Sulfur metabolism_Homo sapiens_hsa009201.02372259
46RNA transport_Homo sapiens_hsa030131.01689708
47Circadian rhythm_Homo sapiens_hsa047100.98741963
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.98042561
49Pyrimidine metabolism_Homo sapiens_hsa002400.95702759
50Oxytocin signaling pathway_Homo sapiens_hsa049210.95138949
51Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91921131
52Long-term potentiation_Homo sapiens_hsa047200.91519807
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.91480419
54Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89646295
55Olfactory transduction_Homo sapiens_hsa047400.88379139
56Oocyte meiosis_Homo sapiens_hsa041140.85795402
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84185918
58Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82926647
59Renin-angiotensin system_Homo sapiens_hsa046140.82758672
60Peroxisome_Homo sapiens_hsa041460.81933555
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.80505529
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80219455
63Regulation of autophagy_Homo sapiens_hsa041400.78984151
64MAPK signaling pathway_Homo sapiens_hsa040100.74846607
65Butanoate metabolism_Homo sapiens_hsa006500.74782944
66Dilated cardiomyopathy_Homo sapiens_hsa054140.74385174
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73994579
68Ether lipid metabolism_Homo sapiens_hsa005650.72581604
69Wnt signaling pathway_Homo sapiens_hsa043100.66790007
70Long-term depression_Homo sapiens_hsa047300.65967287
71Gastric acid secretion_Homo sapiens_hsa049710.65766527
72Nucleotide excision repair_Homo sapiens_hsa034200.63440408
73Hippo signaling pathway_Homo sapiens_hsa043900.63197749
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62921269
75Glycerolipid metabolism_Homo sapiens_hsa005610.61894071
76VEGF signaling pathway_Homo sapiens_hsa043700.61824042
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61066046
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.59629242
79mRNA surveillance pathway_Homo sapiens_hsa030150.56943960
80Lysine degradation_Homo sapiens_hsa003100.56599690
81RNA degradation_Homo sapiens_hsa030180.55529147
82Retinol metabolism_Homo sapiens_hsa008300.55509723
83Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54392787
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53939631
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53418446
86Renin secretion_Homo sapiens_hsa049240.53105859
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51624618
88Fatty acid metabolism_Homo sapiens_hsa012120.51235242
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.51025421
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.50955455
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50798366
92Metabolic pathways_Homo sapiens_hsa011000.50474601
93Purine metabolism_Homo sapiens_hsa002300.50467002
94Fatty acid biosynthesis_Homo sapiens_hsa000610.49056639
95Vitamin digestion and absorption_Homo sapiens_hsa049770.47736019
96Glucagon signaling pathway_Homo sapiens_hsa049220.44613711
97Cholinergic synapse_Homo sapiens_hsa047250.42629118
98Ovarian steroidogenesis_Homo sapiens_hsa049130.42073245
99Gap junction_Homo sapiens_hsa045400.42070172
100beta-Alanine metabolism_Homo sapiens_hsa004100.41904780

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