TMEM237

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a tetraspanin protein that is thought to be involved in WNT signaling. Defects in this gene are a cause of Joubert syndrome-14. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1doxorubicin metabolic process (GO:0044598)8.76541952
2daunorubicin metabolic process (GO:0044597)8.76541952
3polyketide metabolic process (GO:0030638)8.76541952
4regulation of cilium movement (GO:0003352)6.41481292
5aminoglycoside antibiotic metabolic process (GO:0030647)5.89306207
6somite rostral/caudal axis specification (GO:0032525)5.26311223
7maintenance of protein location in nucleus (GO:0051457)5.25954716
8protein localization to cilium (GO:0061512)5.15916975
9regulation of response to osmotic stress (GO:0047484)5.09840970
10protein polyglutamylation (GO:0018095)4.88806463
11microtubule severing (GO:0051013)4.69684234
12negative regulation of epidermis development (GO:0045683)4.66136959
13regulation of nuclear cell cycle DNA replication (GO:0033262)4.64193707
14cullin deneddylation (GO:0010388)4.54595748
15negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.46222982
16chromatin remodeling at centromere (GO:0031055)4.43014225
17CENP-A containing nucleosome assembly (GO:0034080)4.28174740
18regulation of microtubule-based movement (GO:0060632)4.26143998
19regulation of mammary gland epithelial cell proliferation (GO:0033599)4.20976286
20phenol-containing compound catabolic process (GO:0019336)4.20463578
21quinone metabolic process (GO:1901661)4.15609314
22rRNA methylation (GO:0031167)4.12106674
23rRNA transcription (GO:0009303)4.11735509
24negative regulation of telomerase activity (GO:0051974)4.05434236
25ventricular system development (GO:0021591)4.04272085
26negative regulation of cell cycle G2/M phase transition (GO:1902750)4.01738731
27mitotic metaphase plate congression (GO:0007080)3.97515350
28cell fate commitment involved in formation of primary germ layer (GO:0060795)3.93712934
29regulation of telomere maintenance via telomerase (GO:0032210)3.84370500
30protein deneddylation (GO:0000338)3.82596022
31negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.77966050
32mitotic sister chromatid segregation (GO:0000070)3.77943599
33response to dietary excess (GO:0002021)3.77597205
34negative regulation of epidermal cell differentiation (GO:0045605)3.75213896
35DNA strand elongation involved in DNA replication (GO:0006271)3.73063593
36DNA ligation (GO:0006266)3.71030692
37sensory perception of smell (GO:0007608)3.64380785
38regulation of MHC class I biosynthetic process (GO:0045343)3.63158617
39metaphase plate congression (GO:0051310)3.61917413
40rRNA modification (GO:0000154)3.60420905
41DNA strand elongation (GO:0022616)3.60015778
42histone exchange (GO:0043486)3.58320291
43kinetochore organization (GO:0051383)3.56334363
44muscle organ morphogenesis (GO:0048644)3.55608050
45DNA unwinding involved in DNA replication (GO:0006268)3.55031312
46protein localization to kinetochore (GO:0034501)3.53430588
47DNA replication checkpoint (GO:0000076)3.50621638
48telomere maintenance via semi-conservative replication (GO:0032201)3.44811941
49negative regulation of telomere maintenance (GO:0032205)3.42270683
50histone H4-K5 acetylation (GO:0043981)3.40696987
51histone H4-K8 acetylation (GO:0043982)3.40696987
52DNA replication-independent nucleosome assembly (GO:0006336)3.34370965
53DNA replication-independent nucleosome organization (GO:0034724)3.34370965
54mitochondrial DNA replication (GO:0006264)3.32563345
55establishment of melanosome localization (GO:0032401)3.29690061
56histone H4-K12 acetylation (GO:0043983)3.29335219
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24681410
58regulation of centriole replication (GO:0046599)3.21118564
59mitotic chromosome condensation (GO:0007076)3.20875036
60positive regulation of DNA-dependent DNA replication (GO:2000105)3.18889108
61melanosome transport (GO:0032402)3.18310763
62calcium-mediated signaling using intracellular calcium source (GO:0035584)3.17688347
63establishment of pigment granule localization (GO:0051905)3.12494981
64mitotic recombination (GO:0006312)3.11042408
65cardiovascular system development (GO:0072358)3.10731326
66kinetochore assembly (GO:0051382)3.10137522
67DNA damage response, detection of DNA damage (GO:0042769)3.07964174
68notochord development (GO:0030903)3.07559040
69DNA replication-dependent nucleosome assembly (GO:0006335)3.06803584
70DNA replication-dependent nucleosome organization (GO:0034723)3.06803584
71proline transport (GO:0015824)3.06768790
72mitotic sister chromatid cohesion (GO:0007064)3.06544289
73DNA double-strand break processing (GO:0000729)3.06133760
74regulation of pigment cell differentiation (GO:0050932)3.05788463
75nonmotile primary cilium assembly (GO:0035058)3.05691512
76sister chromatid segregation (GO:0000819)3.04423079
77pigment granule transport (GO:0051904)3.00838742
78regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.00792854
79spindle checkpoint (GO:0031577)3.00563780
80GDP-mannose metabolic process (GO:0019673)3.00526015
81detection of temperature stimulus (GO:0016048)3.00310357
82nuclear pore complex assembly (GO:0051292)2.98455011
83axonemal dynein complex assembly (GO:0070286)2.98068658
84mitochondrion distribution (GO:0048311)2.96733690
85cilium movement (GO:0003341)2.96231830
86establishment of chromosome localization (GO:0051303)2.95100705
87replication fork processing (GO:0031297)2.94190263
88telomere maintenance via recombination (GO:0000722)2.94142963
89axon ensheathment in central nervous system (GO:0032291)2.91061249
90central nervous system myelination (GO:0022010)2.91061249
91retinal rod cell development (GO:0046548)2.89862435
92DNA topological change (GO:0006265)2.89116837
93neurotransmitter uptake (GO:0001504)2.88366942
94cytidine deamination (GO:0009972)2.87139327
95cytidine metabolic process (GO:0046087)2.87139327
96cytidine catabolic process (GO:0006216)2.87139327
97negative regulation of smoothened signaling pathway (GO:0045879)2.87041687
98establishment of viral latency (GO:0019043)2.86397330
99negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.86195973
100microtubule depolymerization (GO:0007019)2.86162809
101regulation of telomerase activity (GO:0051972)2.85823071
102regulation of chromosome segregation (GO:0051983)2.84869340
103regulation of telomere maintenance (GO:0032204)2.84036054
104negative regulation of mitotic sister chromatid separation (GO:2000816)2.83787766
105negative regulation of sister chromatid segregation (GO:0033046)2.83787766
106negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.83787766
107negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.83787766
108negative regulation of mitotic sister chromatid segregation (GO:0033048)2.83787766
109interferon-gamma production (GO:0032609)2.83289389
110nucleoside transmembrane transport (GO:1901642)2.83036418
111nuclear pore organization (GO:0006999)2.82770946
112negative regulation of chromosome segregation (GO:0051985)2.82251186
113mitotic spindle checkpoint (GO:0071174)2.80608332
114nucleotide-excision repair, DNA gap filling (GO:0006297)2.80083938
115ventricular cardiac muscle cell development (GO:0055015)2.77214164
116primitive streak formation (GO:0090009)2.74917273
117positive regulation of developmental pigmentation (GO:0048087)2.73218614
118melanosome localization (GO:0032400)2.70726204
119regulation of rhodopsin mediated signaling pathway (GO:0022400)2.70426375
120paraxial mesoderm development (GO:0048339)2.70245138
121motile cilium assembly (GO:0044458)2.70197236
122protein K6-linked ubiquitination (GO:0085020)2.69820685
123regulation of centrosome cycle (GO:0046605)2.69302117
124striatum development (GO:0021756)2.69256114
125coenzyme catabolic process (GO:0009109)2.68654620
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.66732329
127regulation of mitotic metaphase/anaphase transition (GO:0030071)2.66732329
128negative regulation of DNA-dependent DNA replication (GO:2000104)2.66200945
129mitotic spindle assembly checkpoint (GO:0007094)2.65484341
130pseudouridine synthesis (GO:0001522)2.64771045
131spindle assembly checkpoint (GO:0071173)2.64449062
132bone trabecula formation (GO:0060346)2.64444689
133non-recombinational repair (GO:0000726)2.64383469
134double-strand break repair via nonhomologous end joining (GO:0006303)2.64383469
135regulation of spindle organization (GO:0090224)2.63543474
136DNA replication initiation (GO:0006270)2.62962214
137ATP-dependent chromatin remodeling (GO:0043044)2.62894245
138regulation of sister chromatid segregation (GO:0033045)2.62829058
139regulation of mitotic sister chromatid separation (GO:0010965)2.62829058
140regulation of mitotic sister chromatid segregation (GO:0033047)2.62829058
141response to X-ray (GO:0010165)2.62437620
142neuron cell-cell adhesion (GO:0007158)2.62113537
143regulation of apoptotic process involved in morphogenesis (GO:1902337)2.61945062
144regulation of mitotic spindle organization (GO:0060236)2.58417977
145heterochromatin organization (GO:0070828)2.58201252
146epithelial cilium movement (GO:0003351)2.58196759
147pigment granule localization (GO:0051875)2.57420874
148postreplication repair (GO:0006301)2.56631849
149proteasome assembly (GO:0043248)2.56614444
150microtubule polymerization or depolymerization (GO:0031109)2.55473934
151mitochondrial respiratory chain complex I assembly (GO:0032981)2.55222338
152NADH dehydrogenase complex assembly (GO:0010257)2.55222338
153mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.55222338
154regulation of centrosome duplication (GO:0010824)2.55058828
155establishment of integrated proviral latency (GO:0075713)2.55008029
156protein localization to chromosome (GO:0034502)2.54751437
157regulation of sister chromatid cohesion (GO:0007063)2.54715445
158maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.54316486
159protein localization to chromosome, centromeric region (GO:0071459)2.53690007
160vitamin A metabolic process (GO:0006776)2.52156619
161presynaptic membrane assembly (GO:0097105)2.51939799
162rhodopsin mediated signaling pathway (GO:0016056)2.51743758
163icosanoid secretion (GO:0032309)2.51309546
164arachidonic acid secretion (GO:0050482)2.51309546
165regulation of mitotic spindle checkpoint (GO:1903504)2.50936402
166regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.50936402
167translesion synthesis (GO:0019985)2.50413821
168chromosome segregation (GO:0007059)2.50220360
169DNA strand renaturation (GO:0000733)2.49456024
170axoneme assembly (GO:0035082)2.48985495
171attachment of spindle microtubules to kinetochore (GO:0008608)2.48782706
172anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.48617631
173telomere maintenance via telomere lengthening (GO:0010833)2.47804773
174maintenance of protein localization in organelle (GO:0072595)2.47578936
175resolution of meiotic recombination intermediates (GO:0000712)2.46531263
176negative regulation of DNA recombination (GO:0045910)2.46107799
177regulation of DNA endoreduplication (GO:0032875)2.45830535
178chromatin assembly or disassembly (GO:0006333)2.43705978
179mitotic nuclear envelope disassembly (GO:0007077)2.42351510
180regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41649140
181purine nucleobase biosynthetic process (GO:0009113)2.40704662
182mitotic cell cycle (GO:0000278)2.38979387
183chromosome condensation (GO:0030261)2.38243769
184mitotic spindle organization (GO:0007052)2.36747559
185establishment of protein localization to mitochondrial membrane (GO:0090151)2.36142087
186negative regulation of mitosis (GO:0045839)2.36088737
187DNA catabolic process, exonucleolytic (GO:0000738)2.35895979
188mitotic G2/M transition checkpoint (GO:0044818)2.33660335
189negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.33558733
190lateral sprouting from an epithelium (GO:0060601)2.31631579

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.29241414
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.29241414
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.29241414
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human5.04155523
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.57462901
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.16328133
7AR_21909140_ChIP-Seq_LNCAP_Human2.98082158
8SALL1_21062744_ChIP-ChIP_HESCs_Human2.96051167
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.91832546
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.56348381
11IRF1_19129219_ChIP-ChIP_H3396_Human2.52923683
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.46588226
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.39266730
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.27741222
15KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.24131805
16SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.19103461
17RNF2_27304074_Chip-Seq_NSC_Mouse2.07417958
18ELK1_19687146_ChIP-ChIP_HELA_Human2.06394189
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.01634327
20E2F1_21310950_ChIP-Seq_MCF-7_Human1.96425068
21KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.90426963
22POU5F1_16153702_ChIP-ChIP_HESCs_Human1.85423937
23TCF3_18692474_ChIP-Seq_MESCs_Mouse1.82764335
24PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.79940264
25EWS_26573619_Chip-Seq_HEK293_Human1.78555596
26POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.78215047
27VDR_22108803_ChIP-Seq_LS180_Human1.77225533
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.76570467
29E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75523113
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.67365394
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.67060285
32GBX2_23144817_ChIP-Seq_PC3_Human1.66865332
33E2F7_22180533_ChIP-Seq_HELA_Human1.65470791
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62831420
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.59687164
36NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.59305326
37E2F1_17053090_ChIP-ChIP_MCF-7_Human1.57981699
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56248571
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.55314745
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.54283087
41SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.54052015
42NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.53967717
43SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53741638
44TCF3_18692474_ChIP-Seq_MEFs_Mouse1.51029105
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48317995
46PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46940742
47NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.44587837
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.43857937
49ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.43482024
50EST1_17652178_ChIP-ChIP_JURKAT_Human1.43190864
51DCP1A_22483619_ChIP-Seq_HELA_Human1.41956769
52E2F1_18555785_ChIP-Seq_MESCs_Mouse1.41852757
53IGF1R_20145208_ChIP-Seq_DFB_Human1.40536419
54TTF2_22483619_ChIP-Seq_HELA_Human1.39298242
55TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.36064754
56CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.35279787
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34567203
58SOX2_16153702_ChIP-ChIP_HESCs_Human1.33525308
59NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.31623564
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.30711541
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.29279012
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.28644694
63EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.28281391
64MYC_18940864_ChIP-ChIP_HL60_Human1.25867925
65XRN2_22483619_ChIP-Seq_HELA_Human1.25733818
66EZH2_22144423_ChIP-Seq_EOC_Human1.25656126
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.24760986
68FUS_26573619_Chip-Seq_HEK293_Human1.22860862
69NANOG_16153702_ChIP-ChIP_HESCs_Human1.22614460
70CREB1_15753290_ChIP-ChIP_HEK293T_Human1.20082449
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.18818957
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.17321644
73HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.17021296
74MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.16539527
75PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15224827
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13767707
77GATA1_26923725_Chip-Seq_HPCs_Mouse1.13531349
78TAF15_26573619_Chip-Seq_HEK293_Human1.13027444
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.12876724
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.12384189
81SOX9_26525672_Chip-Seq_HEART_Mouse1.12188397
82ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.11263965
83RING1B_27294783_Chip-Seq_NPCs_Mouse1.10333169
84ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09790875
85VDR_23849224_ChIP-Seq_CD4+_Human1.08396469
86SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08331160
87REST_21632747_ChIP-Seq_MESCs_Mouse1.07540090
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.07414599
89ZNF274_21170338_ChIP-Seq_K562_Hela1.07080874
90P300_19829295_ChIP-Seq_ESCs_Human1.06224208
91ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06178711
92SOX17_20123909_ChIP-Seq_XEN_Mouse1.05802624
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.05683256
94ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03098697
95GABP_17652178_ChIP-ChIP_JURKAT_Human1.02748321
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01905511
97GABP_19822575_ChIP-Seq_HepG2_Human1.01538485
98CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01378119
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.00921678
100NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00584889
101NANOG_18692474_ChIP-Seq_MEFs_Mouse1.00211705
102MYC_19030024_ChIP-ChIP_MESCs_Mouse0.99049407
103EOMES_21245162_ChIP-Seq_HESCs_Human0.98456631
104REST_18959480_ChIP-ChIP_MESCs_Mouse0.97584111
105THAP11_20581084_ChIP-Seq_MESCs_Mouse0.96003618
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95931039
107EZH2_27304074_Chip-Seq_ESCs_Mouse0.95687014
108RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94102180
109JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.92611264
110POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.92519327
111NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92181993
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.91571280
113CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.91417053
114PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.91205004
115RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91178560
116KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.89745396
117SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.89477695
118E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89338615
119RNF2_18974828_ChIP-Seq_MESCs_Mouse0.88569347
120EZH2_18974828_ChIP-Seq_MESCs_Mouse0.88569347
121SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88175744
122SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88133914
123CTBP2_25329375_ChIP-Seq_LNCAP_Human0.87691383
124CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.87501796
125TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85986866
126SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85785534
127MYC_18358816_ChIP-ChIP_MESCs_Mouse0.85702982
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.85431986
129SRF_21415370_ChIP-Seq_HL-1_Mouse0.85292591
130NANOG_16518401_ChIP-PET_MESCs_Mouse0.85160240
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83098131
132CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.82878751
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.82847597
134TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82426284
135PIAS1_25552417_ChIP-Seq_VCAP_Human0.82248398
136ELK1_22589737_ChIP-Seq_MCF10A_Human0.82059226
137RNF2_27304074_Chip-Seq_ESCs_Mouse0.81622521
138TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81467848
139KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81171931
140MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80893690
141MYC_18555785_ChIP-Seq_MESCs_Mouse0.80767890
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.80126565
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79762173
144FOXP3_21729870_ChIP-Seq_TREG_Human0.79504160
145SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78740070
146FLI1_27457419_Chip-Seq_LIVER_Mouse0.78327159
147SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.78180580
148HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.78031080
149MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77806299
150PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77414852
151TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.76943778
152P53_22127205_ChIP-Seq_FIBROBLAST_Human0.76818475
153ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.76781454
154STAT3_18555785_ChIP-Seq_MESCs_Mouse0.75676282
155SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.75279563
156FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.74712866

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.79176014
2MP0006292_abnormal_olfactory_placode3.76463479
3MP0003122_maternal_imprinting3.36827167
4MP0010094_abnormal_chromosome_stability2.98949604
5MP0005394_taste/olfaction_phenotype2.86636734
6MP0005499_abnormal_olfactory_system2.86636734
7MP0003890_abnormal_embryonic-extraembry2.62454794
8MP0004858_abnormal_nervous_system2.52181437
9MP0003121_genomic_imprinting2.50581143
10MP0001984_abnormal_olfaction2.49967209
11MP0002653_abnormal_ependyma_morphology2.48959130
12MP0003941_abnormal_skin_development2.37559038
13MP0003111_abnormal_nucleus_morphology2.37366347
14MP0003693_abnormal_embryo_hatching2.34539353
15MP0004264_abnormal_extraembryonic_tissu2.29352956
16MP0006035_abnormal_mitochondrial_morpho2.29248015
17MP0002254_reproductive_system_inflammat2.27244711
18MP0008058_abnormal_DNA_repair2.25480539
19MP0005551_abnormal_eye_electrophysiolog2.10070574
20MP0005075_abnormal_melanosome_morpholog2.06473809
21MP0003880_abnormal_central_pattern2.03885350
22MP0003077_abnormal_cell_cycle2.03536295
23MP0003136_yellow_coat_color1.99011180
24MP0010030_abnormal_orbit_morphology1.94863069
25MP0003938_abnormal_ear_development1.91258788
26MP0008057_abnormal_DNA_replication1.88024059
27MP0003787_abnormal_imprinting1.85316907
28MP0002332_abnormal_exercise_endurance1.84774029
29MP0002938_white_spotting1.81239236
30MP0005253_abnormal_eye_physiology1.80853165
31MP0008007_abnormal_cellular_replicative1.79689781
32MP0009697_abnormal_copulation1.76250419
33MP0002102_abnormal_ear_morphology1.70254917
34MP0006072_abnormal_retinal_apoptosis1.69971449
35MP0004270_analgesia1.60297331
36MP0008789_abnormal_olfactory_epithelium1.58468862
37MP0002697_abnormal_eye_size1.56244649
38MP0001299_abnormal_eye_distance/1.55826051
39MP0009046_muscle_twitch1.54909552
40MP0005410_abnormal_fertilization1.54786326
41MP0004142_abnormal_muscle_tone1.51607627
42MP0001486_abnormal_startle_reflex1.50335307
43MP0004957_abnormal_blastocyst_morpholog1.49184070
44MP0008438_abnormal_cutaneous_collagen1.46759259
45MP0003183_abnormal_peptide_metabolism1.45059535
46MP0001529_abnormal_vocalization1.44246209
47MP0002272_abnormal_nervous_system1.43615485
48MP0002234_abnormal_pharynx_morphology1.41780657
49MP0000049_abnormal_middle_ear1.41523818
50MP0002752_abnormal_somatic_nervous1.40404948
51MP0001905_abnormal_dopamine_level1.40324070
52MP0000631_abnormal_neuroendocrine_gland1.40168496
53MP0005248_abnormal_Harderian_gland1.40115969
54MP0002572_abnormal_emotion/affect_behav1.39468165
55MP0004133_heterotaxia1.39189610
56MP0005503_abnormal_tendon_morphology1.36165774
57MP0002064_seizures1.34751158
58MP0005257_abnormal_intraocular_pressure1.34109976
59MP0003385_abnormal_body_wall1.32962191
60MP0001293_anophthalmia1.32855711
61MP0000579_abnormal_nail_morphology1.31283353
62MP0002734_abnormal_mechanical_nocicepti1.31257324
63MP0002277_abnormal_respiratory_mucosa1.30978192
64MP0000678_abnormal_parathyroid_gland1.30725024
65MP0005391_vision/eye_phenotype1.29761697
66MP0002751_abnormal_autonomic_nervous1.29208521
67MP0009250_abnormal_appendicular_skeleto1.28113286
68MP0009053_abnormal_anal_canal1.26483783
69MP0002233_abnormal_nose_morphology1.26481766
70MP0000778_abnormal_nervous_system1.24185054
71MP0003123_paternal_imprinting1.23660925
72MP0002084_abnormal_developmental_patter1.23586087
73MP0002282_abnormal_trachea_morphology1.22653520
74MP0005195_abnormal_posterior_eye1.22639829
75MP0000537_abnormal_urethra_morphology1.22388800
76MP0002127_abnormal_cardiovascular_syste1.21952220
77MP0002085_abnormal_embryonic_tissue1.21905321
78MP0004272_abnormal_basement_membrane1.21864691
79MP0000428_abnormal_craniofacial_morphol1.21263718
80MP0003119_abnormal_digestive_system1.20981909
81MP0005275_abnormal_skin_tensile1.19504866
82MP0000566_synostosis1.18505611
83MP0003635_abnormal_synaptic_transmissio1.18486723
84MP0004043_abnormal_pH_regulation1.17177192
85MP0000955_abnormal_spinal_cord1.14518078
86MP0003705_abnormal_hypodermis_morpholog1.14447451
87MP0002063_abnormal_learning/memory/cond1.14383388
88MP0001177_atelectasis1.13760077
89MP0002184_abnormal_innervation1.11443425
90MP0000534_abnormal_ureter_morphology1.11256329
91MP0003718_maternal_effect1.11145270
92MP0002932_abnormal_joint_morphology1.09420549
93MP0003950_abnormal_plasma_membrane1.09303369
94MP0005623_abnormal_meninges_morphology1.09068382
95MP0002882_abnormal_neuron_morphology1.08040724
96MP0000762_abnormal_tongue_morphology1.07161816
97MP0002229_neurodegeneration1.06569293
98MP0003786_premature_aging1.06530407
99MP0002111_abnormal_tail_morphology1.05879112
100MP0000647_abnormal_sebaceous_gland1.05767887
101MP0005187_abnormal_penis_morphology1.05601038
102MP0003755_abnormal_palate_morphology1.04382022
103MP0001188_hyperpigmentation1.04082895
104MP0008877_abnormal_DNA_methylation1.03466556
105MP0009672_abnormal_birth_weight1.03425665
106MP0005646_abnormal_pituitary_gland1.03130002
107MP0004197_abnormal_fetal_growth/weight/1.03105080
108MP0003935_abnormal_craniofacial_develop1.03026086
109MP0009745_abnormal_behavioral_response1.00127766
110MP0010368_abnormal_lymphatic_system0.98319552
111MP0002160_abnormal_reproductive_system0.97393082
112MP0001697_abnormal_embryo_size0.97375130
113MP0000350_abnormal_cell_proliferation0.97252396
114MP0002114_abnormal_axial_skeleton0.96735830
115MP0010352_gastrointestinal_tract_polyps0.95218502
116MP0003567_abnormal_fetal_cardiomyocyte0.95122639
117MP0003634_abnormal_glial_cell0.95016915
118MP0008932_abnormal_embryonic_tissue0.94051684
119MP0001730_embryonic_growth_arrest0.93067427
120MP0001963_abnormal_hearing_physiology0.92450261
121MP0002249_abnormal_larynx_morphology0.91902544
122MP0001346_abnormal_lacrimal_gland0.91885846
123MP0003861_abnormal_nervous_system0.90588495
124MP0009703_decreased_birth_body0.90028538
125MP0003937_abnormal_limbs/digits/tail_de0.88936341
126MP0002092_abnormal_eye_morphology0.88814912
127MP0000372_irregular_coat_pigmentation0.88235367
128MP0003632_abnormal_nervous_system0.88175073
129MP0001968_abnormal_touch/_nociception0.88008749
130MP0005171_absent_coat_pigmentation0.87866906
131MP0002067_abnormal_sensory_capabilities0.86961702
132MP0000432_abnormal_head_morphology0.86361396
133MP0006276_abnormal_autonomic_nervous0.85879143
134MP0004859_abnormal_synaptic_plasticity0.84278640
135MP0003315_abnormal_perineum_morphology0.82560658
136MP0009384_cardiac_valve_regurgitation0.82411111
137MP0000026_abnormal_inner_ear0.82038578
138MP0002736_abnormal_nociception_after0.81780935
139MP0003698_abnormal_male_reproductive0.81447364
140MP0002081_perinatal_lethality0.81156901
141MP0001324_abnormal_eye_pigmentation0.80522432
142MP0005423_abnormal_somatic_nervous0.80287236
143MP0002109_abnormal_limb_morphology0.79789672
144MP0003984_embryonic_growth_retardation0.79462499
145MP0002080_prenatal_lethality0.79239212
146MP0002733_abnormal_thermal_nociception0.78806795
147MP0002152_abnormal_brain_morphology0.78465200
148MP0002088_abnormal_embryonic_growth/wei0.77089605
149MP0002116_abnormal_craniofacial_bone0.77030512
150MP0001970_abnormal_pain_threshold0.75742087
151MP0010307_abnormal_tumor_latency0.75230353
152MP0002108_abnormal_muscle_morphology0.75219538
153MP0000920_abnormal_myelination0.74439480
154MP0001440_abnormal_grooming_behavior0.73908232
155MP0001672_abnormal_embryogenesis/_devel0.73855720
156MP0005380_embryogenesis_phenotype0.73855720
157MP0003942_abnormal_urinary_system0.73805688
158MP0001286_abnormal_eye_development0.73408541

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.53646794
2Hypochromic microcytic anemia (HP:0004840)5.06560217
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.74900115
4Hepatoblastoma (HP:0002884)3.84039787
5Hyperventilation (HP:0002883)3.53703491
6Ragged-red muscle fibers (HP:0003200)3.50184761
7Abnormal respiratory motile cilium physiology (HP:0012261)3.37779618
8Rib fusion (HP:0000902)3.34676445
9Increased serum pyruvate (HP:0003542)3.33291267
10Abnormality of glycolysis (HP:0004366)3.33291267
11Sensory axonal neuropathy (HP:0003390)3.31078271
12Bifid tongue (HP:0010297)3.25399591
13Abnormal ciliary motility (HP:0012262)3.19871300
14Abnormal lung lobation (HP:0002101)3.13622620
15Nephroblastoma (Wilms tumor) (HP:0002667)3.13444282
16Aplasia/Hypoplasia of the fovea (HP:0008060)3.09992332
17Hypoplasia of the fovea (HP:0007750)3.09992332
18Abnormality of the lower motor neuron (HP:0002366)3.07967588
19Embryonal renal neoplasm (HP:0011794)2.99806330
20Dyschromatopsia (HP:0007641)2.94272805
21Abnormality of the labia minora (HP:0012880)2.91654744
22Abnormality of the fovea (HP:0000493)2.85674864
23Gait imbalance (HP:0002141)2.82892913
24Supernumerary spleens (HP:0009799)2.80465738
25Abnormality of the corticospinal tract (HP:0002492)2.77702705
26Dynein arm defect of respiratory motile cilia (HP:0012255)2.75776093
27Absent/shortened dynein arms (HP:0200106)2.75776093
28Partial duplication of thumb phalanx (HP:0009944)2.75290743
29Congenital primary aphakia (HP:0007707)2.74359330
30Rhinitis (HP:0012384)2.72448016
31Anomalous pulmonary venous return (HP:0010772)2.70281425
32Pendular nystagmus (HP:0012043)2.70109196
33Ependymoma (HP:0002888)2.68840803
34Inability to walk (HP:0002540)2.67569842
35Febrile seizures (HP:0002373)2.65823252
36Cortical dysplasia (HP:0002539)2.62282056
37Medial flaring of the eyebrow (HP:0010747)2.61612591
38Multiple enchondromatosis (HP:0005701)2.61604517
39Molar tooth sign on MRI (HP:0002419)2.53082442
40Abnormality of midbrain morphology (HP:0002418)2.53082442
41Abnormal respiratory motile cilium morphology (HP:0005938)2.52782132
42Abnormal respiratory epithelium morphology (HP:0012253)2.52782132
43Scotoma (HP:0000575)2.50999060
44Epileptic encephalopathy (HP:0200134)2.49448636
45Chromosomal breakage induced by crosslinking agents (HP:0003221)2.48620868
46Neoplasm of striated muscle (HP:0009728)2.48521589
47Atonic seizures (HP:0010819)2.46855834
48Nephrogenic diabetes insipidus (HP:0009806)2.44012195
49Partial duplication of the phalanx of hand (HP:0009999)2.40529381
50Rhabdomyosarcoma (HP:0002859)2.40345456
51Horizontal nystagmus (HP:0000666)2.39539820
52Broad foot (HP:0001769)2.38759802
53Abnormality of the pulmonary veins (HP:0011718)2.34902046
54Rectovaginal fistula (HP:0000143)2.34667435
55Rectal fistula (HP:0100590)2.34667435
563-Methylglutaconic aciduria (HP:0003535)2.32758376
57Chronic bronchitis (HP:0004469)2.28874894
58Increased nuchal translucency (HP:0010880)2.25034801
59Abnormality of chromosome stability (HP:0003220)2.23944535
60Chromsome breakage (HP:0040012)2.18860850
61Progressive inability to walk (HP:0002505)2.16552822
62Nasolacrimal duct obstruction (HP:0000579)2.16022467
63Microglossia (HP:0000171)2.15227514
64Colon cancer (HP:0003003)2.14813758
65Abnormality of the phalanges of the hallux (HP:0010057)2.13193528
66Astrocytoma (HP:0009592)2.12505643
67Abnormality of the astrocytes (HP:0100707)2.12505643
68Amyotrophic lateral sclerosis (HP:0007354)2.10954379
69Aplasia/hypoplasia of the humerus (HP:0006507)2.08996350
70Abnormality of the preputium (HP:0100587)2.08848124
71Abnormality of the duodenum (HP:0002246)2.08363428
72Vaginal atresia (HP:0000148)2.07421675
73Bony spicule pigmentary retinopathy (HP:0007737)2.07031561
74Abnormality of the salivary glands (HP:0010286)2.05158100
75Genital tract atresia (HP:0001827)2.01688659
76Testicular atrophy (HP:0000029)2.01443892
77Generalized hypotonia (HP:0001290)2.01346400
78Poor coordination (HP:0002370)1.99985045
79Short humerus (HP:0005792)1.99969879
80Congenital stationary night blindness (HP:0007642)1.99528672
81Progressive external ophthalmoplegia (HP:0000590)1.99390964
82Duplication of thumb phalanx (HP:0009942)1.98201341
83Atelectasis (HP:0100750)1.97103577
84Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.96217888
85Fused cervical vertebrae (HP:0002949)1.95639851
86Microvesicular hepatic steatosis (HP:0001414)1.94095577
87Intestinal fistula (HP:0100819)1.93216768
88Hypoplastic pelvis (HP:0008839)1.93054653
89Volvulus (HP:0002580)1.90617185
90Meckel diverticulum (HP:0002245)1.90364645
91Ectopic kidney (HP:0000086)1.90022418
92Amblyopia (HP:0000646)1.89888008
93Gastrointestinal atresia (HP:0002589)1.89712613
94Birth length less than 3rd percentile (HP:0003561)1.88721206
95Selective tooth agenesis (HP:0001592)1.88634946
96Intestinal atresia (HP:0011100)1.88507440
97Aplasia/Hypoplasia of the macula (HP:0008059)1.88068882
98Specific learning disability (HP:0001328)1.87651325
99Duodenal stenosis (HP:0100867)1.87362801
100Small intestinal stenosis (HP:0012848)1.87362801
101Postaxial hand polydactyly (HP:0001162)1.87263231
102Supernumerary nipples (HP:0002558)1.85142516
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.85016977
104Abnormality of dentin (HP:0010299)1.85011083
105Aplasia/Hypoplasia of the lens (HP:0008063)1.84737941
106Triphalangeal thumb (HP:0001199)1.83911472
107Abnormality of the carotid arteries (HP:0005344)1.83681286
108Esophageal atresia (HP:0002032)1.82728107
109Failure to thrive in infancy (HP:0001531)1.82219089
110Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.81233065
111Aplasia/Hypoplasia affecting the retina (HP:0008061)1.81021702
112Abnormality of the ileum (HP:0001549)1.80922059
113Vaginal fistula (HP:0004320)1.80595481
114Degeneration of the lateral corticospinal tracts (HP:0002314)1.80229035
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80229035
116Type I transferrin isoform profile (HP:0003642)1.79114706
117Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.77985570
118Facial cleft (HP:0002006)1.77984706
119Aplasia/Hypoplasia of the uvula (HP:0010293)1.77348901
120Prominent occiput (HP:0000269)1.77040003
121Pancreatic fibrosis (HP:0100732)1.76930877
122Glioma (HP:0009733)1.76790152
123Absent radius (HP:0003974)1.75005967
124Coronal craniosynostosis (HP:0004440)1.74723461
125Cutaneous finger syndactyly (HP:0010554)1.73085265
126Sloping forehead (HP:0000340)1.72211232
127Preaxial hand polydactyly (HP:0001177)1.71672612
128Septo-optic dysplasia (HP:0100842)1.70725910
129Abnormal number of incisors (HP:0011064)1.69665545
130Aplasia involving forearm bones (HP:0009822)1.69481016
131Absent forearm bone (HP:0003953)1.69481016
132Patellar aplasia (HP:0006443)1.67043776
133Cutaneous syndactyly (HP:0012725)1.66054628
134Renal hypoplasia (HP:0000089)1.64137919
135Aplasia/Hypoplasia of the tongue (HP:0010295)1.62916893
136Calcaneovalgus deformity (HP:0001848)1.62252963
137Abnormality of the septum pellucidum (HP:0007375)1.58751226
138High anterior hairline (HP:0009890)1.58633845
139Absent septum pellucidum (HP:0001331)1.57510811
140Hypoplasia of the capital femoral epiphysis (HP:0003090)1.56564148
141Median cleft lip (HP:0000161)1.55410018
142Deformed tarsal bones (HP:0008119)1.54262071
143Anophthalmia (HP:0000528)1.54089699
144Aplasia/Hypoplasia of the patella (HP:0006498)1.53591031
145Horseshoe kidney (HP:0000085)1.50430656
146Medulloblastoma (HP:0002885)1.49631639
147Abnormality of the antihelix (HP:0009738)1.48424923
148Postaxial foot polydactyly (HP:0001830)1.48072388
149Delayed gross motor development (HP:0002194)1.44813052
150Short tibia (HP:0005736)1.43947848
151Soft skin (HP:0000977)1.43325446
152Hypoplastic female external genitalia (HP:0012815)1.41152011
153Retinal dysplasia (HP:0007973)1.41124692
154Neoplasm of the colon (HP:0100273)1.40745290
155Occipital encephalocele (HP:0002085)1.40565691
156Absent epiphyses (HP:0010577)1.40363896
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.40363896
158Premature rupture of membranes (HP:0001788)1.40293493
159Short middle phalanx of the 5th finger (HP:0004220)1.39425319
160* Dandy-Walker malformation (HP:0001305)1.39230987
161Micropenis (HP:0000054)1.38919933
162Small hand (HP:0200055)1.37623800
163Hypoplastic labia majora (HP:0000059)1.37253374
164Abnormal umbilical cord blood vessels (HP:0011403)1.37138219
165Single umbilical artery (HP:0001195)1.37138219
166Abnormality of the fetal cardiovascular system (HP:0010948)1.37138219
167True hermaphroditism (HP:0010459)1.37069366
168Breast hypoplasia (HP:0003187)1.36949574
169Long clavicles (HP:0000890)1.36162261
170Choanal atresia (HP:0000453)1.35866369
171Reticulocytopenia (HP:0001896)1.33617629
172Ankle contracture (HP:0006466)1.32560446
173Stenosis of the external auditory canal (HP:0000402)1.32343208
174Astigmatism (HP:0000483)1.32123383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.26735315
2GRK55.07903536
3CASK3.46747363
4ADRBK23.29655838
5GRK13.13279134
6GRK72.99340082
7GRK62.83903653
8NEK12.69193548
9PLK42.65349624
10VRK22.34575657
11PLK32.27221200
12WNK12.25081623
13TYRO32.23821784
14MAPK72.21395886
15CSF1R2.14765767
16ZAK2.06503375
17MOS2.05962390
18PRPF4B2.04509724
19CDK191.99493174
20EIF2AK11.94252770
21TTK1.90962701
22STK391.86557812
23AKT31.77408275
24NTRK11.72750544
25NUAK11.72002563
26OXSR11.68091064
27TGFBR21.67311732
28LATS11.59102562
29MATK1.58532106
30BRSK11.54696261
31VRK11.51269111
32ERN11.47672623
33ADRBK11.45001729
34EIF2AK31.41680286
35TAF11.39319186
36WNK31.30851233
37MAP2K41.29280445
38PBK1.22721164
39ERBB31.22250839
40BMPR1B1.22152537
41BUB11.20507183
42CDK71.20320368
43EPHB21.11770386
44CDC71.10764674
45AURKB1.10343816
46PLK21.05958890
47MAP3K121.05043252
48MARK21.03564860
49BCR1.00441828
50ATR1.00325257
51STK38L0.97666883
52TRIM280.97374601
53DYRK1A0.96223495
54ERBB40.95796416
55TGFBR10.95775866
56CCNB10.95408584
57TNIK0.95173632
58STK100.93416780
59CHEK20.93155515
60HIPK20.89235334
61DYRK20.89227677
62EPHA40.88904867
63CAMK40.88904678
64PLK10.88657215
65MAPKAPK50.88592221
66PAK40.88212625
67STK160.86364225
68NEK20.85531601
69NTRK20.85070888
70STK30.84784673
71NTRK30.83759897
72CSNK1G30.82670716
73MAP4K20.81884362
74PNCK0.80762982
75MET0.80549962
76PRKG20.77381581
77LATS20.76336976
78ATM0.75673073
79MKNK10.75530743
80UHMK10.74416514
81MAP3K40.71487201
82AURKA0.70758917
83MKNK20.68929948
84MAP2K70.67848373
85CDK180.67044765
86FGFR20.66836807
87CDK150.66301051
88CDK140.66090870
89WNK40.65848894
90PRKCG0.65064734
91RPS6KA40.64441744
92MAPK120.63453502
93LIMK10.63425015
94NME10.62780239
95DYRK30.62776189
96MAPK130.62706525
97SRPK10.62688129
98CDK11A0.62552833
99PAK30.61669553
100FGFR10.60260642
101BRD40.60080826
102CDK80.58085012
103WEE10.53699081
104CSNK1A1L0.53480044
105DMPK0.52909430
106MST40.51601484
107FLT30.50992250
108CAMK2B0.49016730
109CDK10.48961999
110BRAF0.48928654
111MARK10.48493152
112PRKD30.47161537
113CHEK10.47016365
114CDK30.45807368
115PRKDC0.44027547
116TNK20.44009802
117PAK20.43661683
118FGFR30.43340680
119AKT20.42096496
120PDGFRA0.42075875
121TSSK60.41586311
122CSNK1G20.41573123
123PAK60.40751766
124INSRR0.40260452
125STK40.39522623
126MINK10.38796664
127CDK20.38544749
128MAP3K100.38180182
129CDK50.37442642
130CSNK2A10.37181047
131STK240.36969307
132MAP3K90.36057713
133MAP2K60.35798523
134DAPK10.35775256
135EIF2AK20.34949190
136CAMK2A0.34853135
137PRKCE0.33210776
138PAK10.33148725
139CSNK2A20.33074021
140OBSCN0.32734211
141PRKACA0.32477199
142PRKACB0.32164495
143NEK90.30881813
144ARAF0.30347712
145CSNK1E0.30018646
146CAMK2D0.28963961
147ICK0.28729336
148PDK40.28149926
149PDK30.28149926
150BRSK20.27825154
151MAPK100.27750642
152CSNK1G10.27353209

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.28094196
2Vitamin B6 metabolism_Homo sapiens_hsa007504.07237292
3Phototransduction_Homo sapiens_hsa047443.48629710
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57371288
5Fructose and mannose metabolism_Homo sapiens_hsa000512.15847780
6Oxidative phosphorylation_Homo sapiens_hsa001902.15426203
7Olfactory transduction_Homo sapiens_hsa047402.14802255
8Arachidonic acid metabolism_Homo sapiens_hsa005902.13107558
9Ether lipid metabolism_Homo sapiens_hsa005651.97411939
10One carbon pool by folate_Homo sapiens_hsa006701.94308844
11Linoleic acid metabolism_Homo sapiens_hsa005911.91846534
12Collecting duct acid secretion_Homo sapiens_hsa049661.87570536
13Nicotine addiction_Homo sapiens_hsa050331.86861228
14Synaptic vesicle cycle_Homo sapiens_hsa047211.78503360
15Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.76387611
16alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.75104134
17Serotonergic synapse_Homo sapiens_hsa047261.73984340
18Taste transduction_Homo sapiens_hsa047421.73483282
19GABAergic synapse_Homo sapiens_hsa047271.71670140
20Parkinsons disease_Homo sapiens_hsa050121.60968958
21Glutamatergic synapse_Homo sapiens_hsa047241.51260115
22Huntingtons disease_Homo sapiens_hsa050161.40169866
23Vibrio cholerae infection_Homo sapiens_hsa051101.37711738
242-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.37684377
25Propanoate metabolism_Homo sapiens_hsa006401.32831613
26Fanconi anemia pathway_Homo sapiens_hsa034601.31198686
27Mismatch repair_Homo sapiens_hsa034301.31097529
28Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30011045
29Alzheimers disease_Homo sapiens_hsa050101.26029757
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25144790
31Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.24611636
32Proteasome_Homo sapiens_hsa030501.24545023
33p53 signaling pathway_Homo sapiens_hsa041151.23244925
34Pyruvate metabolism_Homo sapiens_hsa006201.21822760
35Non-homologous end-joining_Homo sapiens_hsa034501.20990073
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.19586777
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19314462
38RNA polymerase_Homo sapiens_hsa030201.16578570
39Hedgehog signaling pathway_Homo sapiens_hsa043401.16419077
40Basal transcription factors_Homo sapiens_hsa030221.14774654
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.13245318
42RNA degradation_Homo sapiens_hsa030181.11726668
43RNA transport_Homo sapiens_hsa030131.11536533
44Galactose metabolism_Homo sapiens_hsa000521.10914181
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09567791
46Morphine addiction_Homo sapiens_hsa050321.07031775
47DNA replication_Homo sapiens_hsa030301.06783861
48Long-term depression_Homo sapiens_hsa047301.06644061
49Spliceosome_Homo sapiens_hsa030401.03022218
50Ovarian steroidogenesis_Homo sapiens_hsa049131.02949983
51Folate biosynthesis_Homo sapiens_hsa007901.01767668
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01225336
53Biosynthesis of amino acids_Homo sapiens_hsa012301.00340655
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.97540768
55Homologous recombination_Homo sapiens_hsa034400.97511749
56Cardiac muscle contraction_Homo sapiens_hsa042600.97460721
57Dopaminergic synapse_Homo sapiens_hsa047280.96607689
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.94870236
59Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.94626326
60Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.93056645
61Circadian entrainment_Homo sapiens_hsa047130.92788601
62Pyrimidine metabolism_Homo sapiens_hsa002400.92750001
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90062818
64Selenocompound metabolism_Homo sapiens_hsa004500.89842148
65mRNA surveillance pathway_Homo sapiens_hsa030150.89220576
66TGF-beta signaling pathway_Homo sapiens_hsa043500.88742405
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.87987602
68Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.87567084
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82511153
70Cell cycle_Homo sapiens_hsa041100.81991971
71Axon guidance_Homo sapiens_hsa043600.81925374
72Long-term potentiation_Homo sapiens_hsa047200.81183878
73Basal cell carcinoma_Homo sapiens_hsa052170.81136875
74Fatty acid elongation_Homo sapiens_hsa000620.80931912
75Carbon metabolism_Homo sapiens_hsa012000.80727353
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77401848
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76397635
78Glutathione metabolism_Homo sapiens_hsa004800.75996888
79Amphetamine addiction_Homo sapiens_hsa050310.75822871
80ECM-receptor interaction_Homo sapiens_hsa045120.75276202
81Calcium signaling pathway_Homo sapiens_hsa040200.74468784
82Purine metabolism_Homo sapiens_hsa002300.74017019
83Steroid biosynthesis_Homo sapiens_hsa001000.73917044
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.72735076
85Oocyte meiosis_Homo sapiens_hsa041140.72172025
86Wnt signaling pathway_Homo sapiens_hsa043100.69240899
87Nucleotide excision repair_Homo sapiens_hsa034200.68606166
88Ras signaling pathway_Homo sapiens_hsa040140.67162485
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.67098734
90Alcoholism_Homo sapiens_hsa050340.66591593
91Renin secretion_Homo sapiens_hsa049240.65670757
92Adherens junction_Homo sapiens_hsa045200.65329478
93Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63523786
94MicroRNAs in cancer_Homo sapiens_hsa052060.62068096
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.61494532
96Lysine degradation_Homo sapiens_hsa003100.61196038
97Phospholipase D signaling pathway_Homo sapiens_hsa040720.60734721
98Ribosome_Homo sapiens_hsa030100.59444067
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59100764
100Salivary secretion_Homo sapiens_hsa049700.58990895
101Gap junction_Homo sapiens_hsa045400.58525632
102N-Glycan biosynthesis_Homo sapiens_hsa005100.58358362
103Tight junction_Homo sapiens_hsa045300.58078154
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.57793231
105cAMP signaling pathway_Homo sapiens_hsa040240.57749190
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57708984
107Sphingolipid metabolism_Homo sapiens_hsa006000.56947475
108Protein export_Homo sapiens_hsa030600.55623631
109Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.55027704
110Base excision repair_Homo sapiens_hsa034100.53972347
111Fatty acid metabolism_Homo sapiens_hsa012120.52727419
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50855549
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50522350
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50474729
115Cocaine addiction_Homo sapiens_hsa050300.50320372
116GnRH signaling pathway_Homo sapiens_hsa049120.49697316
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49585019
118Rap1 signaling pathway_Homo sapiens_hsa040150.49140786
119Circadian rhythm_Homo sapiens_hsa047100.49110481
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49026649
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.48402588
122Oxytocin signaling pathway_Homo sapiens_hsa049210.46959889
123Cholinergic synapse_Homo sapiens_hsa047250.46390103
124Melanoma_Homo sapiens_hsa052180.45089581
125Inositol phosphate metabolism_Homo sapiens_hsa005620.44506869
126Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.44048731
127Melanogenesis_Homo sapiens_hsa049160.43308048
128Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42945264
129Butanoate metabolism_Homo sapiens_hsa006500.42479789
130Thyroid cancer_Homo sapiens_hsa052160.41755887
131Colorectal cancer_Homo sapiens_hsa052100.40721801
132Metabolic pathways_Homo sapiens_hsa011000.40710097
133Pathways in cancer_Homo sapiens_hsa052000.40320446
134Hippo signaling pathway_Homo sapiens_hsa043900.39189907
135Rheumatoid arthritis_Homo sapiens_hsa053230.38279663
136Small cell lung cancer_Homo sapiens_hsa052220.37456934
137beta-Alanine metabolism_Homo sapiens_hsa004100.35472110
138Peroxisome_Homo sapiens_hsa041460.33137431
139Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.31970346
140Dilated cardiomyopathy_Homo sapiens_hsa054140.30969248
141Arginine and proline metabolism_Homo sapiens_hsa003300.30688160
142Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22750685
143Fatty acid degradation_Homo sapiens_hsa000710.22746699
144Proteoglycans in cancer_Homo sapiens_hsa052050.22366928
145PI3K-Akt signaling pathway_Homo sapiens_hsa041510.21306867
146Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.20614930
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.20036881
148Sulfur relay system_Homo sapiens_hsa041220.16362712

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