TMEM223

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)6.07209056
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.00242871
3establishment of protein localization to mitochondrial membrane (GO:0090151)5.82600137
4ribosomal small subunit biogenesis (GO:0042274)5.61543872
5energy coupled proton transport, down electrochemical gradient (GO:0015985)5.47416738
6ATP synthesis coupled proton transport (GO:0015986)5.47416738
7mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.11067077
8protein complex biogenesis (GO:0070271)5.10350949
9regulation of mitochondrial translation (GO:0070129)5.03328267
10viral transcription (GO:0019083)4.99604575
11mitochondrial respiratory chain complex assembly (GO:0033108)4.90132772
12translational termination (GO:0006415)4.88363715
13proteasome assembly (GO:0043248)4.77832858
14mitochondrial respiratory chain complex I assembly (GO:0032981)4.76472889
15NADH dehydrogenase complex assembly (GO:0010257)4.76472889
16mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.76472889
17respiratory electron transport chain (GO:0022904)4.66125929
18transcription elongation from RNA polymerase III promoter (GO:0006385)4.60663427
19termination of RNA polymerase III transcription (GO:0006386)4.60663427
20SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.59245474
21electron transport chain (GO:0022900)4.57909389
22cotranslational protein targeting to membrane (GO:0006613)4.51721241
23ribosomal small subunit assembly (GO:0000028)4.50289217
24protein targeting to ER (GO:0045047)4.47679185
25protein targeting to mitochondrion (GO:0006626)4.40022868
26translational elongation (GO:0006414)4.38094139
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.33211621
28establishment of protein localization to endoplasmic reticulum (GO:0072599)4.27840754
29protein localization to endoplasmic reticulum (GO:0070972)4.26207543
30pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.21944721
31maturation of SSU-rRNA (GO:0030490)4.19563074
32translation (GO:0006412)4.16171288
33establishment of protein localization to mitochondrion (GO:0072655)4.12154189
34rRNA modification (GO:0000154)4.05519044
35cullin deneddylation (GO:0010388)4.04414310
36base-excision repair, AP site formation (GO:0006285)3.99924006
37protein localization to mitochondrion (GO:0070585)3.99144776
38ribosomal large subunit biogenesis (GO:0042273)3.95710174
39viral life cycle (GO:0019058)3.90868088
40protein deneddylation (GO:0000338)3.90832600
41respiratory chain complex IV assembly (GO:0008535)3.88275839
42translational initiation (GO:0006413)3.87192621
43pseudouridine synthesis (GO:0001522)3.86824575
44cellular component biogenesis (GO:0044085)3.85315796
45cytochrome complex assembly (GO:0017004)3.83188841
46spliceosomal snRNP assembly (GO:0000387)3.82332291
47RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.78218768
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.78218768
49negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.76116631
50nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.73820580
51ribonucleoprotein complex biogenesis (GO:0022613)3.70554507
52cellular protein complex disassembly (GO:0043624)3.68731210
53DNA replication checkpoint (GO:0000076)3.67582896
54peptidyl-histidine modification (GO:0018202)3.63455349
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.63423658
56protein neddylation (GO:0045116)3.61325122
57exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.60683850
58rRNA processing (GO:0006364)3.54431175
59pyrimidine nucleotide catabolic process (GO:0006244)3.52987489
60GTP biosynthetic process (GO:0006183)3.50629724
61negative regulation of ligase activity (GO:0051352)3.43567771
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.43567771
63pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.38948992
64rRNA metabolic process (GO:0016072)3.38887445
65regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.37301068
66oxidative phosphorylation (GO:0006119)3.36629096
67purine nucleoside triphosphate biosynthetic process (GO:0009145)3.36294256
68purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.35245785
69guanosine-containing compound biosynthetic process (GO:1901070)3.34809364
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32590290
71DNA damage response, detection of DNA damage (GO:0042769)3.30536141
72ATP biosynthetic process (GO:0006754)3.30387699
73chromatin remodeling at centromere (GO:0031055)3.30211372
74DNA deamination (GO:0045006)3.28675477
75rRNA methylation (GO:0031167)3.26608585
76protein-cofactor linkage (GO:0018065)3.26418703
77intracellular protein transmembrane import (GO:0044743)3.24610339
78mitochondrial transport (GO:0006839)3.23373557
79UTP biosynthetic process (GO:0006228)3.22216260
80CENP-A containing nucleosome assembly (GO:0034080)3.20255194
81anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.19259486
82kinetochore assembly (GO:0051382)3.18038089
83regulation of cellular amino acid metabolic process (GO:0006521)3.17777868
84water-soluble vitamin biosynthetic process (GO:0042364)3.16643930
85tRNA processing (GO:0008033)3.15678592
86protein complex disassembly (GO:0043241)3.14075836
87metallo-sulfur cluster assembly (GO:0031163)3.11778239
88iron-sulfur cluster assembly (GO:0016226)3.11778239
89ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10086476
90deoxyribonucleotide catabolic process (GO:0009264)3.09538597
91L-serine metabolic process (GO:0006563)3.08684518
92inner mitochondrial membrane organization (GO:0007007)3.05188802
93DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04981213
94telomere maintenance via semi-conservative replication (GO:0032201)3.04929654
95pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03904026
96ribosome biogenesis (GO:0042254)3.02015127
97macromolecular complex disassembly (GO:0032984)3.00491328
98pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.99845028
99protein targeting to membrane (GO:0006612)2.99231533
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.97226173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.82972003
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.51025450
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.29755676
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.97079844
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.91993548
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.73435343
7HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.58976098
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.57933511
9CREB1_15753290_ChIP-ChIP_HEK293T_Human3.34144048
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.28339836
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.16066820
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11361332
13SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.04700103
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.01805265
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.01026912
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.77817603
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.75049655
18THAP11_20581084_ChIP-Seq_MESCs_Mouse2.74970687
19E2F7_22180533_ChIP-Seq_HELA_Human2.73002466
20* VDR_23849224_ChIP-Seq_CD4+_Human2.59498675
21XRN2_22483619_ChIP-Seq_HELA_Human2.58877404
22FOXP3_21729870_ChIP-Seq_TREG_Human2.50856323
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.47738857
24SRF_21415370_ChIP-Seq_HL-1_Mouse2.45443522
25DCP1A_22483619_ChIP-Seq_HELA_Human2.40171532
26GABP_19822575_ChIP-Seq_HepG2_Human2.36105802
27PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.30270362
28E2F1_18555785_ChIP-Seq_MESCs_Mouse2.29724236
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25556595
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.17901223
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.07506078
32TTF2_22483619_ChIP-Seq_HELA_Human2.07356717
33ELK1_19687146_ChIP-ChIP_HELA_Human2.03760863
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00373096
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.98493232
36TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.95518121
37ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90377324
38CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.87392516
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.87039213
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86181251
41PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74740404
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65713313
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65505396
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59720846
45MYC_18940864_ChIP-ChIP_HL60_Human1.56811660
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.54065793
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51256625
48CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.46619202
49MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45995897
50BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.43020377
51POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.42674434
52* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.42297634
53* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.41883935
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.41394964
55* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40923053
56KDM5A_27292631_Chip-Seq_BREAST_Human1.40311897
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.38102417
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33488550
59PADI4_21655091_ChIP-ChIP_MCF-7_Human1.29358359
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.26503917
61* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25683581
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24045103
63HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21472728
64CIITA_25753668_ChIP-Seq_RAJI_Human1.21455601
65E2F1_21310950_ChIP-Seq_MCF-7_Human1.19984393
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19450274
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.19350143
68E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19281520
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.14412247
70* FOXP1_21924763_ChIP-Seq_HESCs_Human1.14099133
71NOTCH1_21737748_ChIP-Seq_TLL_Human1.13403908
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.13309814
73SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08285051
74* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07865094
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.07168055
76ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05166539
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03553433
78TET1_21451524_ChIP-Seq_MESCs_Mouse0.97170190
79ZNF263_19887448_ChIP-Seq_K562_Human0.94938016
80FOXM1_23109430_ChIP-Seq_U2OS_Human0.94927919
81SOX2_18555785_ChIP-Seq_MESCs_Mouse0.93232264
82* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91608237
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88898931
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88038851
85CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86858643
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84815442
87TFEB_21752829_ChIP-Seq_HELA_Human0.81705671
88TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81376964
89EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79915594
90CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.78123461
91* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77917160
92TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77535269
93IRF1_19129219_ChIP-ChIP_H3396_Human0.76961001
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76340125
95STAT3_1855785_ChIP-Seq_MESCs_Mouse0.75058976
96RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.74830510
97KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74622195
98TP63_19390658_ChIP-ChIP_HaCaT_Human0.72632876
99SRY_22984422_ChIP-ChIP_TESTIS_Rat0.72486407
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.71696246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008058_abnormal_DNA_repair3.78526971
2MP0000372_irregular_coat_pigmentation3.71285089
3MP0003806_abnormal_nucleotide_metabolis3.50349643
4MP0003693_abnormal_embryo_hatching3.43099110
5MP0003186_abnormal_redox_activity3.19042243
6MP0010094_abnormal_chromosome_stability3.13742310
7MP0004957_abnormal_blastocyst_morpholog3.01019167
8MP0006036_abnormal_mitochondrial_physio2.89454484
9MP0008932_abnormal_embryonic_tissue2.70552069
10MP0003136_yellow_coat_color2.70214897
11MP0009379_abnormal_foot_pigmentation2.62549843
12MP0003786_premature_aging2.61365105
13MP0010030_abnormal_orbit_morphology2.51842740
14MP0003111_abnormal_nucleus_morphology2.49563105
15MP0006035_abnormal_mitochondrial_morpho2.35922540
16MP0003077_abnormal_cell_cycle2.35537818
17MP0002938_white_spotting2.13713038
18MP0006292_abnormal_olfactory_placode2.10105335
19MP0002277_abnormal_respiratory_mucosa2.01068117
20MP0008007_abnormal_cellular_replicative2.00577338
21MP0003718_maternal_effect1.99498021
22MP0001764_abnormal_homeostasis1.95758097
23MP0002736_abnormal_nociception_after1.88388795
24MP0000049_abnormal_middle_ear1.87307238
25MP0002234_abnormal_pharynx_morphology1.78362562
26MP0002837_dystrophic_cardiac_calcinosis1.72849293
27MP0005075_abnormal_melanosome_morpholog1.72118602
28MP0005084_abnormal_gallbladder_morpholo1.71580773
29MP0004133_heterotaxia1.64422049
30MP0001529_abnormal_vocalization1.58081981
31MP0002160_abnormal_reproductive_system1.55335127
32MP0008789_abnormal_olfactory_epithelium1.46895851
33MP0000358_abnormal_cell_content/1.41644888
34MP0006072_abnormal_retinal_apoptosis1.41138101
35MP0005332_abnormal_amino_acid1.37047264
36MP0002102_abnormal_ear_morphology1.33207455
37MP0009697_abnormal_copulation1.33118532
38MP0002163_abnormal_gland_morphology1.32072174
39MP0002132_abnormal_respiratory_system1.31633271
40MP0001293_anophthalmia1.31476429
41MP0005670_abnormal_white_adipose1.30705582
42MP0008260_abnormal_autophagy1.28347568
43MP0005408_hypopigmentation1.27713137
44MP0001919_abnormal_reproductive_system1.27195517
45MP0008995_early_reproductive_senescence1.26953795
46MP0005389_reproductive_system_phenotype1.26141545
47MP0003315_abnormal_perineum_morphology1.22838799
48MP0002653_abnormal_ependyma_morphology1.19063673
49MP0003011_delayed_dark_adaptation1.16358994
50MP0002254_reproductive_system_inflammat1.15954367
51MP0003941_abnormal_skin_development1.15002820
52MP0002095_abnormal_skin_pigmentation1.10646304
53MP0001188_hyperpigmentation1.08817114
54MP0003119_abnormal_digestive_system1.04411171
55MP0001968_abnormal_touch/_nociception1.02958170
56MP0001905_abnormal_dopamine_level1.02652642
57MP0004147_increased_porphyrin_level1.02437937
58MP0008875_abnormal_xenobiotic_pharmacok1.01484765
59MP0005501_abnormal_skin_physiology1.01059252
60MP0008877_abnormal_DNA_methylation0.99488828
61MP0002210_abnormal_sex_determination0.98350550
62MP0002177_abnormal_outer_ear0.96189900
63MP0005174_abnormal_tail_pigmentation0.95127350
64MP0008057_abnormal_DNA_replication0.94524529
65MP0000350_abnormal_cell_proliferation0.93145376
66MP0000313_abnormal_cell_death0.91427984
67MP0005499_abnormal_olfactory_system0.91218667
68MP0005394_taste/olfaction_phenotype0.91218667
69MP0003937_abnormal_limbs/digits/tail_de0.90432979
70MP0001697_abnormal_embryo_size0.85349210
71MP0003567_abnormal_fetal_cardiomyocyte0.84667596
72MP0001929_abnormal_gametogenesis0.82532174
73MP0001145_abnormal_male_reproductive0.82269071
74MP0000015_abnormal_ear_pigmentation0.81997020
75MP0009250_abnormal_appendicular_skeleto0.81941173
76MP0000653_abnormal_sex_gland0.80816744
77MP0002090_abnormal_vision0.79543070
78MP0003123_paternal_imprinting0.79174279
79MP0005636_abnormal_mineral_homeostasis0.77870341
80MP0008872_abnormal_physiological_respon0.75328484
81MP0002249_abnormal_larynx_morphology0.74854369
82MP0003938_abnormal_ear_development0.72295977
83MP0000631_abnormal_neuroendocrine_gland0.70902244
84MP0001324_abnormal_eye_pigmentation0.69651209
85MP0002796_impaired_skin_barrier0.68416732
86MP0001485_abnormal_pinna_reflex0.67562488
87MP0001119_abnormal_female_reproductive0.67281137
88MP0001881_abnormal_mammary_gland0.66364288
89MP0002638_abnormal_pupillary_reflex0.66351826
90MP0001346_abnormal_lacrimal_gland0.66026094
91MP0000678_abnormal_parathyroid_gland0.64857420
92MP0001730_embryonic_growth_arrest0.64804045
93MP0005253_abnormal_eye_physiology0.63985104
94MP0003137_abnormal_impulse_conducting0.63754678
95MP0004019_abnormal_vitamin_homeostasis0.63611256
96MP0005330_cardiomyopathy0.61684498
97MP0002876_abnormal_thyroid_physiology0.61312497
98MP0002233_abnormal_nose_morphology0.60638782
99MP0005551_abnormal_eye_electrophysiolog0.60462387
100MP0003195_calcinosis0.60276812

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.90750002
2Abnormal mitochondria in muscle tissue (HP:0008316)5.64729964
3Acute encephalopathy (HP:0006846)5.42592804
4Mitochondrial inheritance (HP:0001427)5.33719659
5Increased hepatocellular lipid droplets (HP:0006565)5.00540307
6Increased CSF lactate (HP:0002490)4.87558476
7Lipid accumulation in hepatocytes (HP:0006561)4.77731336
8Progressive macrocephaly (HP:0004481)4.74839512
9Renal Fanconi syndrome (HP:0001994)4.44102998
10Hepatocellular necrosis (HP:0001404)4.40251677
11Cerebral edema (HP:0002181)4.17433171
12Increased intramyocellular lipid droplets (HP:0012240)4.02764512
13Hepatic necrosis (HP:0002605)3.98059777
143-Methylglutaconic aciduria (HP:0003535)3.78043489
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.69513421
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.69513421
17Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.61962067
18Increased muscle lipid content (HP:0009058)3.59133799
19Lactic acidosis (HP:0003128)3.50593599
20Abnormal number of erythroid precursors (HP:0012131)3.45982994
21Increased serum lactate (HP:0002151)3.42104367
22Abnormality of cells of the erythroid lineage (HP:0012130)3.34516893
23Reticulocytopenia (HP:0001896)3.33359774
24Respiratory difficulties (HP:0002880)3.30055653
25Exercise intolerance (HP:0003546)3.24552182
26Exertional dyspnea (HP:0002875)3.18486351
27Macrocytic anemia (HP:0001972)3.11978066
28Respiratory failure (HP:0002878)3.04904764
29Type I transferrin isoform profile (HP:0003642)3.04657998
30Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.84477479
31Lethargy (HP:0001254)2.81864494
32Abnormal protein N-linked glycosylation (HP:0012347)2.78478920
33Abnormal protein glycosylation (HP:0012346)2.78478920
34Abnormal glycosylation (HP:0012345)2.78478920
35Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.78478920
36Optic disc pallor (HP:0000543)2.71975979
37Microvesicular hepatic steatosis (HP:0001414)2.71288544
38Abnormality of renal resorption (HP:0011038)2.70549116
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63955464
40Abnormality of alanine metabolism (HP:0010916)2.63955464
41Hyperalaninemia (HP:0003348)2.63955464
42Leukodystrophy (HP:0002415)2.56248567
43Colon cancer (HP:0003003)2.54794671
44Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50278334
45Methylmalonic aciduria (HP:0012120)2.47467134
46Glycosuria (HP:0003076)2.43738168
47Abnormality of urine glucose concentration (HP:0011016)2.43738168
48Testicular atrophy (HP:0000029)2.35416894
49Hyperglycinemia (HP:0002154)2.30450739
50Aplastic anemia (HP:0001915)2.29831332
51Abnormality of serum amino acid levels (HP:0003112)2.28092157
52Microretrognathia (HP:0000308)2.27393896
53Cerebral hypomyelination (HP:0006808)2.26245661
54Reduced antithrombin III activity (HP:0001976)2.25093731
55Pallor (HP:0000980)2.19762692
56Absent thumb (HP:0009777)2.19685846
57Abnormality of methionine metabolism (HP:0010901)2.19631964
58Opisthotonus (HP:0002179)2.18305373
59Aplasia/hypoplasia of the uterus (HP:0008684)2.16570545
60Increased serum pyruvate (HP:0003542)2.15810994
61Methylmalonic acidemia (HP:0002912)2.15401540
62Hyperphosphaturia (HP:0003109)2.08924665
63Pancytopenia (HP:0001876)2.07421941
64Abnormality of dicarboxylic acid metabolism (HP:0010995)2.06619311
65Dicarboxylic aciduria (HP:0003215)2.06619311
66CNS demyelination (HP:0007305)2.05908373
67Emotional lability (HP:0000712)1.94374305
68Sclerocornea (HP:0000647)1.91518610
69Meckel diverticulum (HP:0002245)1.90204128
70Cleft eyelid (HP:0000625)1.87134506
71Abnormality of glycolysis (HP:0004366)1.86388459
72Congenital malformation of the right heart (HP:0011723)1.86211183
73Double outlet right ventricle (HP:0001719)1.86211183
74Pancreatic cysts (HP:0001737)1.85168360
75Molar tooth sign on MRI (HP:0002419)1.83722378
76Abnormality of midbrain morphology (HP:0002418)1.83722378
77Horseshoe kidney (HP:0000085)1.82565750
78Multiple enchondromatosis (HP:0005701)1.82475312
79X-linked dominant inheritance (HP:0001423)1.82116241
80Abnormality of the ileum (HP:0001549)1.81046075
81Abnormality of aspartate family amino acid metabolism (HP:0010899)1.80857167
82Blindness (HP:0000618)1.80850891
83Abnormality of the labia minora (HP:0012880)1.80327934
84Birth length less than 3rd percentile (HP:0003561)1.79336332
85Progressive muscle weakness (HP:0003323)1.77899720
86Abnormality of the preputium (HP:0100587)1.75980555
87Generalized aminoaciduria (HP:0002909)1.74597070
88Progressive microcephaly (HP:0000253)1.74569781
89Abnormality of the anterior horn cell (HP:0006802)1.73312677
90Degeneration of anterior horn cells (HP:0002398)1.73312677
91Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72701142
92Hypoplasia of the uterus (HP:0000013)1.72619999
93Medial flaring of the eyebrow (HP:0010747)1.72563898
94Pancreatic fibrosis (HP:0100732)1.71464388
95Megaloblastic anemia (HP:0001889)1.70245305
96Ragged-red muscle fibers (HP:0003200)1.69192626
97Renal tubular dysfunction (HP:0000124)1.67436732
98Sparse eyelashes (HP:0000653)1.67377302
99Abnormal urine phosphate concentration (HP:0012599)1.65770270
100Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.64638201

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.30015405
2BUB14.50125247
3BCKDK4.25617205
4NME23.63372338
5STK163.18073085
6TLK13.08562584
7CDC72.52343346
8SRPK12.28349039
9VRK12.21660225
10ZAK2.06361451
11NUAK12.02053237
12PDK21.93886578
13NME11.82330289
14MAP4K21.70205930
15TRIM281.66595931
16TAF11.62335302
17TESK21.59263779
18CSNK1G31.54050263
19NEK11.53580864
20DYRK21.48777875
21EIF2AK31.42600304
22PBK1.42058287
23KDR1.41717866
24EIF2AK11.41091946
25CSNK1G11.33894938
26ABL21.28990256
27PIM21.27177750
28CSNK1A1L1.26440648
29INSRR1.22396326
30BRSK11.20423812
31CSNK1G21.20010331
32AURKA1.19196842
33PLK11.18432197
34PLK41.15537492
35CHEK21.11580461
36PLK31.07849258
37AURKB1.05240262
38LIMK11.04912047
39WEE11.02846779
40MAPKAPK31.02081261
41TESK11.00911412
42DAPK10.96454493
43BRSK20.95783609
44TTK0.93945416
45MAP2K70.93732189
46ATR0.92994542
47RPS6KA50.91067268
48GRK10.87866562
49TSSK60.87722747
50WNK30.85464507
51BMPR1B0.81263672
52EIF2AK20.81094723
53CSNK2A10.79286833
54DAPK30.78544638
55CSNK2A20.74576907
56PINK10.72863209
57MAP3K110.72031872
58MST40.70496907
59CDK80.69048797
60CDK190.67225373
61WNK40.64914459
62DYRK30.64008209
63PRKCI0.63877670
64TNIK0.61702664
65ADRBK20.61115164
66TAOK20.60223050
67CDK70.59155571
68ILK0.57763392
69STK40.57424000
70MAPKAPK50.56979792
71SMG10.56763836
72ARAF0.51728302
73MUSK0.48026108
74PASK0.47282915
75ATM0.45146954
76GRK50.44349159
77CHEK10.43863120
78MATK0.42324788
79CCNB10.41703763
80CSNK1A10.40853942
81PHKG10.38991516
82PHKG20.38991516
83CASK0.37937859
84TAOK10.37672383
85PAK10.36266355
86OXSR10.34997511
87IKBKB0.33061626
88EPHA20.32713660
89RPS6KB20.32684903
90PAK40.31666026
91BRAF0.31516466
92LRRK20.30463819
93CSNK1E0.30125607
94MKNK10.27289790
95CDK40.24512036
96AKT20.24022421
97RPS6KA40.23979038
98GRK60.23936140
99ADRBK10.23826270
100ALK0.23380656

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.71517748
2Oxidative phosphorylation_Homo sapiens_hsa001903.89295635
3Proteasome_Homo sapiens_hsa030503.65714748
4Parkinsons disease_Homo sapiens_hsa050123.33639756
5RNA polymerase_Homo sapiens_hsa030203.19474902
6DNA replication_Homo sapiens_hsa030302.87578346
7Sulfur relay system_Homo sapiens_hsa041222.68463944
8Mismatch repair_Homo sapiens_hsa034302.56438537
9Base excision repair_Homo sapiens_hsa034102.46401198
10Huntingtons disease_Homo sapiens_hsa050162.45802039
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44660662
12Protein export_Homo sapiens_hsa030602.30851803
13Homologous recombination_Homo sapiens_hsa034402.30811627
14Alzheimers disease_Homo sapiens_hsa050102.19662111
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08366962
16Pyrimidine metabolism_Homo sapiens_hsa002402.05282093
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.98620203
18Spliceosome_Homo sapiens_hsa030401.86202349
19One carbon pool by folate_Homo sapiens_hsa006701.81057716
20Fanconi anemia pathway_Homo sapiens_hsa034601.74131656
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.70981605
22Nucleotide excision repair_Homo sapiens_hsa034201.66508300
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43914198
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.41451839
25Basal transcription factors_Homo sapiens_hsa030221.40414453
26Folate biosynthesis_Homo sapiens_hsa007901.39688666
27RNA transport_Homo sapiens_hsa030131.35003690
28Cysteine and methionine metabolism_Homo sapiens_hsa002701.33747473
29Purine metabolism_Homo sapiens_hsa002301.32847150
30Fatty acid elongation_Homo sapiens_hsa000621.30347384
31RNA degradation_Homo sapiens_hsa030181.30092899
32Cardiac muscle contraction_Homo sapiens_hsa042601.28641136
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.27228612
34Glutathione metabolism_Homo sapiens_hsa004801.27038775
35Non-homologous end-joining_Homo sapiens_hsa034501.22101868
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.14525105
37Pyruvate metabolism_Homo sapiens_hsa006201.14263088
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12761303
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09154783
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.03799587
41Propanoate metabolism_Homo sapiens_hsa006401.03493657
42Metabolic pathways_Homo sapiens_hsa011000.93631842
43Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93464028
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92972360
45Biosynthesis of amino acids_Homo sapiens_hsa012300.91645197
46Vitamin B6 metabolism_Homo sapiens_hsa007500.91502511
47Steroid biosynthesis_Homo sapiens_hsa001000.90678785
48Peroxisome_Homo sapiens_hsa041460.89798222
49Sulfur metabolism_Homo sapiens_hsa009200.87646776
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78810422
51Drug metabolism - other enzymes_Homo sapiens_hsa009830.76496474
52Carbon metabolism_Homo sapiens_hsa012000.76213309
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75960694
54Cell cycle_Homo sapiens_hsa041100.75583611
55Selenocompound metabolism_Homo sapiens_hsa004500.75094245
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.73019533
57Chemical carcinogenesis_Homo sapiens_hsa052040.68849970
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68814221
59Arginine and proline metabolism_Homo sapiens_hsa003300.66959037
60Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66389791
61N-Glycan biosynthesis_Homo sapiens_hsa005100.62165545
62Cyanoamino acid metabolism_Homo sapiens_hsa004600.61119017
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54987455
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54885717
65Galactose metabolism_Homo sapiens_hsa000520.54412262
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.52805874
67Butanoate metabolism_Homo sapiens_hsa006500.51125637
68Regulation of autophagy_Homo sapiens_hsa041400.50228944
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.49870074
70Collecting duct acid secretion_Homo sapiens_hsa049660.49242967
71beta-Alanine metabolism_Homo sapiens_hsa004100.48642391
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47919850
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47324177
74Tyrosine metabolism_Homo sapiens_hsa003500.45008067
75Retinol metabolism_Homo sapiens_hsa008300.44933837
76p53 signaling pathway_Homo sapiens_hsa041150.44772513
77Vitamin digestion and absorption_Homo sapiens_hsa049770.43963939
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41882694
79Fatty acid degradation_Homo sapiens_hsa000710.40782311
80Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37910773
81mRNA surveillance pathway_Homo sapiens_hsa030150.37345370
82Systemic lupus erythematosus_Homo sapiens_hsa053220.34013699
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.33791289
84Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33741445
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33505526
86Fructose and mannose metabolism_Homo sapiens_hsa000510.33039570
87Tryptophan metabolism_Homo sapiens_hsa003800.32539290
88Basal cell carcinoma_Homo sapiens_hsa052170.31766229
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.29881316
90Caffeine metabolism_Homo sapiens_hsa002320.28100375
91Fat digestion and absorption_Homo sapiens_hsa049750.27853863
92Pentose phosphate pathway_Homo sapiens_hsa000300.27117274
93Primary immunodeficiency_Homo sapiens_hsa053400.26001876
94Fatty acid metabolism_Homo sapiens_hsa012120.25265750
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.24635650
96Phenylalanine metabolism_Homo sapiens_hsa003600.24610719
97Epstein-Barr virus infection_Homo sapiens_hsa051690.23785889
98Nitrogen metabolism_Homo sapiens_hsa009100.21016553
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19704428
100Arginine biosynthesis_Homo sapiens_hsa002200.19576490

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